SHINAGAWA Kunihiro 品川邦汎

Researcher Number	60133906
External Links
Affiliation (based on the past Project Information) *help	2010: 岩手大学, 農学部, 教授 2006 – 2008: 岩手大学, 農学部, 教授 2005: 岩手大学, 農学部・獣医学科, 教授 2005: Iwate University, Department of Veterinary Medicine, Professor, 農学部獣医学科, 教授 1995 – 2004: 岩手大学, 農学部, 教授 … More 2003: Iwate University, Department of Agriculture, professor, 農学部・獣医学科, 教授 2002: 岩手大学, 農学部獣医学科, 教授 1999: 岩手大学, 農学部・獣医学科, 教授 1992 – 1993: 岩手大学, 農学部, 助教授 1986 – 1989: 岩手大学, 農学部, 助教授 Less
Review Section/Research Field	Principal Investigator Applied veterinary science / Applied veterinary science Except Principal Investigator Applied veterinary science / 基礎獣医学 / Applied veterinary science / Fisheries chemistry
Keywords	Principal Investigator recombinant DNA / diagnosis / Staphylococcal enterotoxin / S.aureus / S. aureus / emesis / Staphylococcus aureus / pathogenicity islands / genome biology / plasmids … More / enterotoxin production / enterotoxin gene (se-gene) / Staphylococcal enterotoxin (SE) / Bacillus cereus / エンテロトキシン / セレウス菌 / detection / Enzyme-linked immunosorbent assay (ELISA) / diarrheagenic toxin / enterotoxin / 毒素の検出 / 下痢原性毒素 / ブドウ球菌 / モノクローナル抗体 / 毒素検出法 / 免疫学的毒素精製法 / モノクロ-ナル抗体 / ブドウ球菌エンテロトキシン / セレウス菌下痢毒素 / staphylococcal enterotoxin / pathogenicity island / biological activities / SEI / SEH / SEG / Suncus murinus / protein expression / mice lethality / Shiga toxin (Stx) / cytokines / anti-O antigen antibody / bovine colostrum / Shiga toxin-producing Escherichia coli / 志賀毒素 Ig-G抗体価 / 志賀毒素 2 / 志賀毒素 1 / O157 Ig-G抗体価 / Escherichia coli O157:H7 / Enterohemorrhagic E.coli / マウス致死 / 志賀毒素(STx) / サイトカイン / O抗体価 / 牛初乳 / 腸管出血性大腸菌 / Suncus / Emetic toxin / HEp-2 vacuole factor / INF- / Epitope / Synthetic peptide / Enterotoxin A / 致死活性 / 催吐活性 / 嘔吐毒 / エビトープ / 抗ペプチド抗体 / INF-γ産生 / HEp-2細胞空胞化変生物質 / スンクス / セレウス菌嘔吐毒 / IFN-γ産生 / 抗原決定部位 / 合成ペプチド / エンテロトキシンA / 黄色ブドウ球菌 / Stanhvlococcal enterotoxin / 食品衛生学 / 食中毒 / 獣医公衆衛生 … More Except Principal Investigator pathogenicity islands / genome biology / recombinant DNA / Staphylococcal enterotoxin / diagnosis / S. aureus / plasmids / S.aureus / saxitoxin / ELISA / 胎盤移送 / Mn-54 / Zn-65 / 放射性亜鉛 / ブドウ球菌 / 食中毒 / placental transfer / whole-body retention / Zn-deficiency / metabolism / zinc / 臓器分布 / 体内残留 / 代謝 / 代謝回転 / 放射性物質 / 胎子移行 / 亜鉛欠乏 / ガンマ線照射 / 体内残留率 / 消化管吸収 / Neurotoxin / Enterotoxin / Toxin / Food-poisoning / Staphylococcus aureus / Bacillus cereus / Aeromonas hydrophila / C. perfringens / Clostridium botulinum / 作用機構 / 嘔吐毒 / 下痢毒 / セレウス菌 / エンテロトキシン / 神経毒 / モノクローナル抗体 / 検出方法 / 作用機序 / 分子構造 / 黄色ブドウ球菌 / セレウス球 / エロモナス / ウェルシュ菌 / ボツリヌス菌 / 毒素 / Staphylcoccal enterotoxin / deagnosis / S.aurreus / gonyautoxin / ethanedithiol / thiol / antigen / hapten / paralytic shellfish toxins / マレイミド / ポリクローナル抗体 / 牛血清アルブミン / ポリリジン / 簡易測定法 / 抗体 / 麻ひ性貝毒-チオール複合体 / 麻ひ性貝毒 / サキシトキシン / ゴニオトキシン / エタンジチオール / チオール / 抗原 / ハプテン / 麻痺性貝毒 / milk / placental / radioactive manganese / radioactive zinc / experimental animals / 乳汁分泌 / ラット / マウス / 乳 / 胎盤 / 放射性マンガン / 実験動物 / ブトウ球菌 / スーパー抗原 / 嘔吐活性 / 細菌毒素 / 食品衛生学 / 獣医公衆衛生 Less

New paradigm of staphylococcal food poisoning
- Principal Investigator
  
  OMOE Katsuhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Genomics based analysis of pathogenicity evolution of Staphylococcal aureusPrincipal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Comparative genomics of staphylococcal enterotoxin gene family
- Principal Investigator
  
  OMOE Katsuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Genome biology of staphylococcal enterotoxin familyPrincipal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
ゲノムバイオロジーを基盤とする黄色ブドウ球菌の分子疫学と危害評価
- Principal Investigator
  
  OMOE Katsuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Risk analysis of staphylococcal enterotoxin type G, H, I, and J in milk and meat.Principal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Development of simple analyzing method for paralytic shellfish toxins by ELISA
- Principal Investigator
  
  SATO Shigeru
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fisheries chemistry
- Research Institution
  Kitasato University
Application of molecular biological technologies to epidemiology of new staphylococcal enterotoxinsPrincipal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Seroepidemiological studies on domestic animal and human diseases infected with enterohemorrhagic Escherichia coli.Principal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Iwate University
Studies on Structure and Fanction of Staphylococcal Enterotoxin and Bacillus cereus emetic toxinPrincipal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Faculty of Agriculture, Iwate University
Studies on Placental Transfer and Milk Secretion of Zn-65 and Mn-54 in Experimental Animals
- Principal Investigator
  
  MATSUSAKA Naonori
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  IWATE UNIVERSITY
Immunological application of monoclonal antibodies to detect bacterial toxins produced in foodsPrincipal Investigator
- Principal Investigator
  
  SHINAGAWA Kunihiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Faculty of Agriculture, Iwate University
Studies on the roles of bacterial toxins in food poisoning and its prevention
- Principal Investigator
  
  SAKAGUCHI Genji
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  University of Osaka Prefecture
Studies on metabolisms of radioactive materials and radiosensitivity under zinc deficiency
- Principal Investigator
  
  MATSUSAKA Naonori
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Iwate University

All 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] High affinity of interaction between superantigen and T cell receptor VP molecules induces a high level and prolonged expansion of superantigen-reactive CD4^+ T cells.2010
- Author(s)
  Omoe K., Nunomura W., Kato H., Li Z.-J., Igarashi O., Araake M., Sano K., Ono H.K., Abe Y., Hu D.-L., Nakane A., Kiyono H., Takakuwa Y., Shinagawa K., Uchiyama T., Imanishi K.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 30427-30435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580338
[Journal Article] Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEAD227A, protects against enterotoxin-induced emesis in house musk shrews.2009
- Author(s)
  Hu D.-L., Omoe K., Sashinami H., Shinagawa K., Nakane A.
- Journal Title
  
  J.Infect.Dis. 199
  
  Pages: 302-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580338
[Journal Article] Identification and characterization of two novel staphylococcal enterotoxins, types S and T. Infect2008
- Author(s)
  Ono, H. K., Omoe, K., Imanishi, K., Iwakabe, Y., Hu, D.-L., Kato, H., Saito, N., Nakane, A., Uchiyama, T., and Shinagawa, K.
- Journal Title
  
  Immun 76
  
  Pages: 4999-5005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380173
[Journal Article] Identification and characterization of two novel staphylococcal enterotoxins, types S and T.2008
- Author(s)
  Ono H. K., Omoe K., Imanishi K., Iwakabe Y., Hu D.-L., Kato H., Saito N., Nakane A., Uchiyama T., Shinagawa K.
- Journal Title
  
  Infect.Immun. 76
  
  Pages: 4999-5005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580338
[Journal Article] Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is down-regulated by cannabinoid receptor 12007
- Author(s)
  Hu, D. -L., Zhu, G., Mori, F., Omoe, K., Okada, M., Wakabayashi, K., Kaneko, S., Shinagawa, K. and Nakane, A.
- Journal Title
  
  Cell. Microbiol 9
  
  Pages: 2267-2277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580304
[Journal Article] Food poisoning attributable to Staphylococus aureus deficient in all of the staphylococcal enterotoxin gene so far reported.2006
- Author(s)
  Kuramoto, S., Kodama, H., Yamada, K., Inui, I., Kitagawa, E., Kawakami, K., Satomi, R., Ikawa, A., Omoe, K., and Shinagawa, K.
- Journal Title
  
  Jpn. J. Infect. Dis. 59
  
  Pages: 347-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580304
[Journal Article] Intranasal vaccination with a double mutant of staphylococcal enterotoxin C provides protection against Staphylococcus aureus infection2006
- Author(s)
  Hu, D. -L., Omoe, K., Narita, K., Cui, J. -C., Shinagawa, K. and Nakane, A.
- Journal Title
  
  Mirobes Infect 8
  
  Pages: 2841-2848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580304
[Journal Article] Comparative prevalence of superantigenic toxin genes in methicillin-resistant and methicillin-susceptible Staphylococcus aureusisolates
- Author(s)
  Hu, D.-L., Omoe, K., Inoue, F., Kasai, T., Yasujima, M., Shinagawa, K. and Nakane, A.
- Journal Title
  
  J. Med. Microbiol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580304
[Presentation] ブドウ球菌エンテロトキシンAの標的細胞は肥満細胞である2010
- Author(s)
  小野久弥、廣瀬昌平、山本欣郎、胡東良、中根明夫、品川邦汎、重茂克彦
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸市・神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] ブドウ球菌エンテロトキシンAの消化管における動態と標的細胞の解析2010
- Author(s)
  小野久弥、重茂克彦、胡東艮、中根明夫、品川邦汎
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜市・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] Analysis o f staphylococcal enterotoxin type A movement in gastrointestinal tract of house musk shrew and characterization of target cell of toxin.2010
- Author(s)
  Ono H.K., Nishizawa M., Yamamoto Y., Hu D.-L., Nakane A., Shinagawa K., Omoe K.
- Organizer
  14th International Symposium on Staphylococci and Staphylococcal Infections
- Place of Presentation
  Bath, UK
- Year and Date
  2010-09-07
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] ブドウ球菌エンテロトキシンAの消化管における動態2009
- Author(s)
  小野久弥,重茂克彦,山本欣郎,胡東良,中根明夫,品川邦汎
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市・パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] 新型ブドウ球菌エンテロトキシン(SEs)の食品中における産生量評価2009
- Author(s)
  長廻ゆりあ,重茂克彦,稲垣華絵,山本裕紀,胡東良,中根明夫,品川邦汎
- Organizer
  第63回日本細菌学会東北支部総会
- Place of Presentation
  盛岡市・岩手県歯科医師会館
- Year and Date
  2009-08-20
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] New SEB-encoding Staphylococcus aureus pathogenicity island.2008
- Author(s)
  Omoe K., Misu H., Saito M., Nukui T., Hu D.-L., Nakane A., Shinagawa K.
- Organizer
  13th International Symposium on Staphylococci and Staphylococcal Infections
- Place of Presentation
  Cairns, Commonwealth of Australia
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] 霊長類モデルによるブドウ球菌エンテロトキシン群嘔吐活性の解析2008
- Author(s)
  重茂克彦, 今西健一, 胡東良, 加藤秀人, 中根明夫, 内山竹彦, 品川邦汎
- Organizer
  第81回日本細菌学会総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] New SEB-encoding Staphylococcus aureus pathogenicity island2008
- Author(s)
  Omoe, K., Misu, H., Saito, M., Nukui, T., Hu, D.-L., Nakane, A., and Shinagawa, K.
- Organizer
  13th International Symposium on Staphylococci and Staphylococcal Infections
- Place of Presentation
  Cairns
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] ブドウ球菌エンテロトキシンB関連可動性遺伝因子の多様性2008
- Author(s)
  重茂克彦、見須秀基、斉藤恵、温井健司、小野久弥、胡東良、中根明夫、品川邦汎
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] 新規エンテロトキシンSESおよびSETの生物活性2008
- Author(s)
  小野久弥、重茂克彦、今西健一、胡東良、加藤秀人、中根明夫、内山竹彦、品川邦汎
- Organizer
  第55回毒素シンポジウム
- Place of Presentation
  山中湖町
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] ブドウ球菌エンテロトキシン(Ses)の高感度検出法の確立と黄色ブドウ球菌株におけるSes産生量評価2008
- Author(s)
  稲垣華絵、重茂克彦、小野久弥、胡東良、中根明夫、品川邦汎
- Organizer
  第62回日本細菌学会東北支部会
- Place of Presentation
  十和田市
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] ブドウ球菌エンテロトキシン(SEs)の高感度検出法の確立と黄色ブドウ球菌株におけるSEs産生量評価2008
- Author(s)
  稲垣華絵、重茂克彦、小野久弥、胡東良、中根明夫、品川邦汎
- Organizer
  第62回日本細菌学会東北支部会
- Place of Presentation
  十和田市
- Data Source
  KAKENHI-PROJECT-20580338
[Presentation] ブドウ球菌エンテロトキシン保有プラスミドにコードされる新規エンテロトキシン2007
- Author(s)
  小野久弥, 重茂克彦, 今西健一, 岩壁佳宏, 胡東良, 加藤秀人, 斎藤直之, 中根明夫, 内山竹彦, 品川邦汎
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  江別市
- Data Source
  KAKENHI-PROJECT-19380173
[Presentation] 新型ブドウ球菌エンテロトキシン群嘔吐活性の霊長類モデルによる解析2007
- Author(s)
  重茂克彦, 近藤祐子, 今西健一, 胡東良, 斎藤直之, 加藤秀人, 中根明夫, 内山竹彦, 品川邦汎
- Organizer
  第54回毒素シンポジウム
- Place of Presentation
  大阪府
- Data Source
  KAKENHI-PROJECT-19380173

1. OMOE KATSUHIKO (60224309)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
2. MATSUSAKA Naonori (70003754)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NAKANE Akiko (30164239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SATO Itaru (60225919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NISHIMURA Yoshikazu (20164600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIGA Akio (20003783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOBAYASHI Haruo (60003779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIRANO Norio (40092308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITO Kikuji (50100045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SATO Shigerito (20112592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SATO Shigeru (40050588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SAKAI Ryuichi (20265721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKAGUCHI Genji (50081477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOZAKI Shunji (10109895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ASAO Tsutomu (00250318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. UEMURA Takashi (40081591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐藤繁 (20170748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 浅尾努 (00250316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 浅尾努 (00250317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NAKAZAWA Muneo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SUGIYAMA Junichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHINAGAWA Kunihiro 品川 邦汎

Research Projects

Research Products

Co-Researchers

New paradigm of staphylococcal food poisoning

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomics based analysis of pathogenicity evolution of Staphylococcal aureusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparative genomics of staphylococcal enterotoxin gene family

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genome biology of staphylococcal enterotoxin familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノムバイオロジーを基盤とする黄色ブドウ球菌の分子疫学と危害評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Risk analysis of staphylococcal enterotoxin type G, H, I, and J in milk and meat.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of simple analyzing method for paralytic shellfish toxins by ELISA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of molecular biological technologies to epidemiology of new staphylococcal enterotoxinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Seroepidemiological studies on domestic animal and human diseases infected with enterohemorrhagic Escherichia coli.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Structure and Fanction of Staphylococcal Enterotoxin and Bacillus cereus emetic toxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Placental Transfer and Milk Secretion of Zn-65 and Mn-54 in Experimental Animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunological application of monoclonal antibodies to detect bacterial toxins produced in foodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the roles of bacterial toxins in food poisoning and its prevention

Principal Investigator

Project Period (FY)

Research Category

SHINAGAWA Kunihiro 品川邦汎