SASAGURI Yasuyuki 笹栗靖之

… Alternative Names

笹栗靖之ササグリヤスユキ

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Researcher Number	60140646
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2014: University of Occupational and Environmental Health, Japan, 医学部, 教授 2000 – 2004: 産業医科大学, 医学部, 教授 1993: 産業医科大学, 教授 1992: 久留米大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Experimental pathology Except Principal Investigator Experimental pathology / Biological Sciences / Circulatory organs internal medicine / Human pathology / Circulatory organs internal medicine / Digestive surgery / Tumor biology / General pharmacology
Keywords	Principal Investigator ヒスタミン / メタボリック症候群 / レドックス機構 / ペルオキシレドキシン / 動脈硬化 / 疾患モデル動物 Except Principal Investigator PAF-AH / 動脈硬化 / 遺伝子導入 / アデノウイルス … More / NF-Y / gene transfer / injured arteries / inflammation / thrombosis / 血栓症 / TFPI / 障害血管 / 炎症 / 血栓 / MMp-9 / ヒスタミン / ノックアウトマウス / 浸潤 / 転移 / TGF-β / 遺伝子治療 / 可溶型受容体 / 腫瘍血管新生 / bone marrow-derived progenitor cell / angiopoietin-1 / oxidized lipoproteins / 血管 / 傷害 / 酸化LDL / Angiopoietin-1 / 血小板活性化因子水解酵素(PAF-AH) / 骨髄由来前駆細胞 / アンギオポイエチン-1 / 酸化脂質 / RAF-AH / Cell proliferation / cancer / 増殖マーカー / 癌 / C-type natriuretic peptide / extracelluar matrix protein / 人工血管 / 抗血栓分子 / 不全心筋 / 糖尿病 / 傷害血管 / 再狭窄 / CNP / 細胞外基質 / nude rat / nude mouse / Timp-1 / metastatic model / metastasis / invasion / metabloproteinase / セリンプロテアーゼ / 肝転移 / ヒト大腸癌 / ヌードラット / In site Hybridization / 大腸癌 / TIMp-1 / ヌードマウス / 転移モデル / メタロプロテアーゼ / がん制御遺伝子 / Drug resistance / Topoisomerase 1 / Y-box binding protein 1 / 薬剤感受性 / 転写関連因子 / 耐性 / がん化学療法 / 抗がん剤 / マウスモデル / 骨粗鬆症 / 粥状動脈硬化 / ヒスタミンレセプター / HR/apoE-KOマウス / HDC/apoE-KOマウス / ヒスチジン脱炭酸酵素(HDC) / 炎症因子 / スカベンジャー受容体 / HR / apoE-KOマウス / HDC / ヒスチジン脱炭酸酵素 / ヒスタミンレセプター(HR) / 老化 / 心肥大 / メタボリック症候群 / 腎臓病 / 心不全 / 脂質代謝 / 高脂血症 / 一酸化窒素 / 心筋梗塞 / 一酸化窒素合成酵素 / MMP / ヒアルロン酸 / CD44 / FGF / VEGF Less

Functional analysis and expression of YB-1 in cancer cells, for integrated understanding
- Principal Investigator
  
  KOHNO Kimitoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of histamine in atherosclerosis and osteoporosis
- Principal Investigator
  
  TANIMOTO Akihide
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kagoshima University
Elucidation of the significance of the nitric oxide synthase system in vivo by the use of mice lacking all nitric oxide synthases
- Principal Investigator
  
  TSUTSUI Masato
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan
Novel function of histamine in atherosclerotic artery
- Principal Investigator
  
  TANIMOTO Akihide
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Occupational and Environmental Health, Japan
Role of Peroxiredoxin on Metabolic SyndoromePrincipal Investigator
- Principal Investigator
  
  SASAGURI Yasuyuki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Occupational and Environmental Health, Japan
細胞外マトリクス制御分子群を用いた抗浸潤・転移療法の開発
- Principal Investigator
  
  上野光
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
Gene transfer-mediated molecular analysis of pathophysiology in injured arteries and development of local anti-inflammatory and anti-thrombotic therapy
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health
血管新生抑制分子・転移抑制分子を用いた癌の遺伝子治療法の開発
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Occupational and Environmental Health, Japan
Gene transfer-mediated molecular analysis of pathophysiology in injured arteries
- Principal Investigator
  
  UENO Hikaru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health
Expression of NF-Y in cancer tissue and its relation to cell proliferation
- Principal Investigator
  
  TANIMOTO Akihide
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Okinaka Memorial Institute for Medical Research
  University of Occupational and Environmental Health, Japan
The Role of Metalloproteinases Related with invasion and Metastasis in Colon Cance.
- Principal Investigator
  
  MORODOMI Tatsuhisa
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kurume University School of Medicine

All 2012 2011 2010 2009 2008 2005

All Journal Article Presentation

[Journal Article] Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer.2012
- Author(s)
  Wu, Y., Yamada, S., Izumi, H., Li, Z., Shimajiri, S., Wang, K.Y., Liu, Y.P., Kohno, K., Sasaguri, Y.
- Journal Title
  
  Journal of Surgical Oncology
  
  Volume: 105 Issue: 7 Pages: 724-730
- DOI
  10.1002/jso.23030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501323
[Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.2011
- Author(s)
  Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. in press
- Data Source
  KAKENHI-PROJECT-20590416
[Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level.2011
- Author(s)
  Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 31
  
  Pages: 800-807
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Role of histamine in atherosclerotic lesion.2010
- Author(s)
  Wang KY, Tanimoto A, Sasaguri Y.
- Journal Title
  
  J UOEH. 32(Review)
  
  Pages: 63-71
- NAID
  110007588849
- Data Source
  KAKENHI-PROJECT-20590416
[Journal Article] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases.2010
- Author(s)
  Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M.
- Journal Title
  
  Circ J. 74
  
  Pages: 2681-2692
- NAID
  10027424618
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. Model for Nonalcoholic Steatohepatitis in Mice.2010
- Author(s)
  Wang KY, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Watanabe T, Kohno K, Hirano KI, Tsukada H, Sasaguri Y.
- Journal Title
  
  Am J Pathol. 177
  
  Pages: 713-723
- Data Source
  KAKENHI-PROJECT-20590416
[Journal Article] Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.2010
- Author(s)
  Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M.
- Journal Title
  
  Cardiovasc Res. 87
  
  Pages: 675-682
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] OVEREXPRESSION OF PEROXIREDOXIN4 PROTECTS AGAINST HIGH-DOSE STREPTOZOTOCIN-INDUCED DIABETES BY SUPPRESSING OXIDATIVE STRESS AND CYTOKINES IN TRANSGENIC MICE2010
- Author(s)
  YAN DING, 1 SOHSUKE YAMADA, 1KE-YONG WANG, 1 SHOHEI SHIMAJIRI, 1 XIN GUO, 1 AKIHIDE TANIMOTO, 2, 1 SHUJI KITAJIMA, 3 TERUO WATANABE, 4 HIROTO IZUMI, 5 KIMITOSHI KOHNO, 5 YASUYUKI SASAGURI1
- Journal Title
  
  Antioxidants & Redox Signaling (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590413
[Journal Article] 動脈硬化病変におけるヒスタミンの役割2010
- Author(s)
  王克よう, 谷本昭英, 笹栗靖之
- Journal Title
  
  産業医科大学雑誌 32
  
  Pages: 63-71
- NAID
  110007588849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590416
[Journal Article] Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.2010
- Author(s)
  Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M.
- Journal Title
  
  J Pharmacol Sci. 114
  
  Pages: 379-389
- NAID
  10029890896
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Nitric oxide synthases and cardiovascular diseases-Insights form genetically modified mice-2009
- Author(s)
  Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N.
- Journal Title
  
  Circ J 73(Review)
  
  Pages: 986-993
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Matrix metalloproteinase 12 is factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks fibrous plaques in transgenic rabbits.2008
- Author(s)
  Yamada S, Wang KY, Tanimoto A, Fan Shimajiri S, Kitajima S, Tsutsui Watanabe T, Yasumoto K, Sasaguri Y.
- Journal Title
  
  Am J Pathol. 172
  
  Pages: 1419-1429
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.2008
- Author(s)
  Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K, Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N.
- Journal Title
  
  Circulation. 117
  
  Pages: 2211-2223
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.2008
- Author(s)
  Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y.
- Journal Title
  
  Am J Respir Crit Care Med. 177
  
  Pages: 219-226
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo : Involvement of the renin-angiotensin system.2008
- Author(s)
  Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N.
- Journal Title
  
  J Bone Miner Res. 23(5)
  
  Pages: 633-643
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells.2008
- Author(s)
  Tanimoto A, Murata Y, Wang KY, Tsutsui M, Kohno K, Sasaguri Y.
- Journal Title
  
  J Biol Chem. 283(8)
  
  Pages: 4643-4651
- Data Source
  KAKENHI-PROJECT-20390074
[Journal Article] Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxideized lipoproteins, and inhibits inflammation, shear stress-induced thrombosis,and neointima formation in balloon-injured carotid arteries in non-hyperlipidemic rabbits.2005
- Author(s)
  Arakawa H, Qian J-Y, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H
- Journal Title
  
  Circulation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Journal Article] Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.2005
- Author(s)
  Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H
- Journal Title
  
  Gasteroenterology 128
  
  Pages: 138-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390255
[Presentation] 粥状動脈硬化におけるヒスタミン受容体(HH1R、HH2R)の役割2010
- Author(s)
  王克よう, 谷本昭英, 笹栗靖之
- Organizer
  日本病理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590416

1. UENO Hikaru (50260378)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. TANIMOTO Akihide (10217151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. KOHNO Kimitoshi (00153479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. TSUTSUI Masato (70309962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. UETA Youichi (10232745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. YANAGIHARA Nobuyuki (80140896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. SHIMOKAWA Hiroaki (00235681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. SASAGURI Yasuyuki (60140648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WANG Ke-Yong (30369053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MORODOMI Tatsuhisa (80166462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIURA Kazuhide (20209711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHKITA Akira (50203724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AKAGI Yoshito (90192880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIROUZU Kazuo (20216203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUDA Takehisa (60142189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HAMADA Hirofumi (00189614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ASADA Yujiro (70202588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. NISHIDA Takahiro (50284500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中西洋一 (20172356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田中良哉 (30248562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 緒方裕 (20177124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 武谷浩之 (60222105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 王克ヨン

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAGURI Yasuyuki 笹栗 靖之

笹栗 靖之 ササグリ ヤスユキ

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Role of Peroxiredoxin on Metabolic SyndoromePrincipal Investigator

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[Journal Article] Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer.2012

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[Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apoE-KO mice independently on serum cholesterol level.2011

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[Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level.2011

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[Journal Article] Role of histamine in atherosclerotic lesion.2010

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[Journal Article] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases.2010

SASAGURI Yasuyuki 笹栗靖之

笹栗靖之ササグリヤスユキ