MURAYAMA Tsugiya 村山次哉

Researcher Number	60159184
Affiliation (Current)	2022: 北陸大学, 薬学部, 研究員
Affiliation (based on the past Project Information) *help	2017: 北陸大学, 薬学部, 研究員 2009 – 2016: 北陸大学, 薬学部, 教授 2005 – 2006: 北陸大学, 薬学部, 教授 2004: 鹿児島大学, 大学院・医歯学総合研究科, 助教授 1999: Faculty of Medicine, Kagoshima University, Associate Professor, 医学部, 助教授 1998: 金沢医科大学, 助教授 1995 – 1998: 金沢医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Infectious disease medicine / Virology / Embryonic/Neonatal medicine Except Principal Investigator Infectious disease medicine / Neurology
Keywords	Principal Investigator サイトメガロウイルス / AP-1 / NF-kB / IL-8 / Cytomegalovirus / トリシン / 抗ウイルス薬 / ケモカイン / THP-1 / Northern blot … More / UL146 / STAT3 / siRNA / ノーザンブロット / IL-8レセプター / Interleukin 8 / ルシフェラーゼ発現ベクター / U363MG細胞 / ゲルシフトアッセイ / U373MG細胞 / 免疫染色 / 遺伝子導入 / THP-1細胞 / U373MG cell / luciferase reporter gene assay / 臨床分離株 / 融合タンパク質 / 臨床分離株HCMV / BAC / 臨床分離株CMV / Clinical isolated strain / Fusion protein / ヒトサイトメガロウイルス / 抗HCMV薬 / CCL2 / CCL5 … More Except Principal Investigator 腫瘍 / 悪性 / シスプラチン耐性 / in vivo薬剤耐性 / メタロチオネイン / トランスポーター / cMOAT / ウイルス / 感染症 / 脂質 / 免疫学 / 遺伝子 / タイラーウイルス / 中枢神経 / 外来遺伝子 / ベクター / マクロファージ / Theiler's virus / CNS / lymphotoxin gene / vector / macrophages Less

Study of the molecular mechanisms of novel therapeutic candidate for cytomegalovirus infectionPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Hokuriku University
Analysis of molecular mechanisms of new anti-virus drug against human cytomegalovirus infectious diseasesPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Hokuriku University
Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections
- Principal Investigator
  
  TAKAHASHI Takashi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kitasato University
Studies on virulence of new gene products of cytomegalovirusPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Hokuriku University
  Kagoshima University
微小環境における腫瘍細胞の悪性誘導機序の解析と制御
- Principal Investigator
  
  宮本謙一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kanazawa University
Molecular mechanisms of IL-8 gene expression by the immediate early gene products of cytomegelovirusPrincipal Investigator
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kagoshima University
  Kanazawa Medical University
Theiler's virus as a vector for foreign gene delivery into the CNS
- Principal Investigator
  
  OHARA Yoshiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa Medical University
Molecular mechanisms for enhancement of human cytomegalovirus replication by chemokine, interleukin 8Principal Investigator
- Principal Investigator
  
  MURAYAMA Tsugiya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kanazawa Medical University

[Book] “化学療法の領域、特集・飛躍的に発展を見せる抗ウイルス薬”2017
- Author(s)
  村山次哉
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K09587
[Book] 応用細胞補完代替医療学2012
- Author(s)
  村山次哉
- Total Pages
  93
- Publisher
  大学教育出版
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9.2018
- Author(s)
  Hidetaka Sadanari, Kazuhiro J. Fujimoto, Yuto Sugihara, Tomoki Ishida, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 8 Pages: 646-654
- DOI
  10.1002/2211-5463.12398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05670, KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587, KAKENHI-PROJECT-16K09929
[Journal Article] An in silico-designed flavone derivative, 6-fluoro-4′-hydroxy-3′,5′-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells2018
- Author(s)
  Kazuhiro J. Fujimoto, Daiki Nema, Masayuki Ninomiya, Mamoru Koketsu, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
- Journal Title
  
  Antiviral Res.
  
  Volume: 154 Pages: 10-16
- DOI
  10.1016/j.antiviral.2018.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05670, KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587, KAKENHI-PROJECT-16K09929
[Journal Article] クマザサ含有成分によるCCL2依存性のヒトサイトメガロウイルス増殖抑制効果2017
- Author(s)
  赤井佑三子、茂木香保里、定成秀貴、武本眞清、松原京子、大黒　徹、土田裕三、桜井大輔、村山次哉
- Journal Title
  
  日本補完代替医療学会誌
  
  Volume: 14 Pages: 83-93
- NAID
  130006147572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] CCL2/CCR2-dependent replication of human cytomegalovirus is inhibited by anti-inflammatory compound tricin.2017
- Author(s)
  Tsugiya Murayama, Daiki Nema, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Naofumi Mukaida
- Journal Title
  
  Cytokines (Special Issue)
  
  Volume: 100 Pages: 80-80
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression.2017
- Author(s)
  Yumiko Akai, Hidetaka Sadanari, MasayaTakemoto, Noboru Uchide, Tohru Daikoku, Naofumi Mukaida, Tsugiya Murayama
- Journal Title
  
  Antiviral Res.
  
  Volume: 148 Pages: 15-19
- DOI
  10.1016/j.antiviral.2017.09.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587
[Journal Article] Inhibition of CCL2 dependent human cytomegalovirus replication by tricin.2016
- Author(s)
  Tsugiya Murayama, Rie Yamada, Keiko Matsubara, Hidetaka Sadanari
- Journal Title
  
  F1000 Research
  
  Volume: 5 Pages: 561-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] Regulation of matrix metalloproteinases-2 and -9 gene expression in cultured human fetal membrane cells by influenza virus infection.2016
- Author(s)
  Noboru Uchide, Kyoko Obatake, Rie Yamada, Hidetaka Sadanari, Keiko Matsubara, Tsugiya Murayama, Kunio Ohyam
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 39 Pages: 1912-1921
- NAID
  130005171512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] Synergistic effects of combination treatment with ganciclovir and tricin on human cytomegalovirus replication in vitro. Antiviral Research.2016
- Author(s)
  Rie Yamada, Hideki Suda, Hidetaka Sadanari, Keiko Matsubara, Yuuzo Tuchida, Tsugiya Murayama
- Journal Title
  
  Antiviral Research
  
  Volume: 125 Pages: 79-83
- DOI
  10.1016/j.antiviral.2015.11.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] イネ科植物含有成分“Tricin”による抗ヒトサイトメガロウイルス作用機序の解明2015
- Author(s)
  村山次哉
- Journal Title
  
  New Food Industry
  
  Volume: 57 Pages: 24-34
- NAID
  40020470504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09587
[Journal Article] イネ科植物含有成分“Tricin”による抗ヒトサイトメガロウイルス作用機序の解明2015
- Author(s)
  村山次哉
- Journal Title
  
  New Food Industry
  
  Volume: 57 Pages: 24-34
- NAID
  40020470504
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Quantitative & Qualitative Regulation of Peripheral Leukocyteｓ Subsets plus Emotional Hormones by Floor Heating.2014
- Author(s)
  Nobuo Yamaguchi, Amat Nurmuhammad, Jameas Zhao, Xiefeng Jia, Jiao Jian, Rui Chen, Tsugiya Murayama
- Journal Title
  
  Open Journal of Reumatology & Autoimmune diseases
  
  Volume: 4 Pages: 97-105
- DOI
  10.4236/ojra.2014.42015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Human cytomegalovirus replication supported by virus-induced activation of CCL2-CCR2 interactions.2014
- Author(s)
  T. Murayama, M. Kikuchi, T. Miita, R. Yamada, K. Matsubara, H. Sadanari, N. Mukaida
- Journal Title
  
  Biochem. Biophis. Res. Commun.
  
  Volume: 453 Pages: 321-325
- DOI
  10.1016/j.bbrc.2014.09.071
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Transgenic rice seed synthesizing diverse flavonoids at high levels: a new platform for flavonoid production with associated health benefits.2013
- Author(s)
  Y. Ogo, K. Ozawa, T. Ishimaru, T. Murayama and F. Takaiwa
- Journal Title
  
  Plant Biotechnol J
  
  Volume: 11 Pages: 734-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Transgenic rice seed synthesizing diverse flavonoids at high levels: a new platform for flavonoid production with associated health benefits2013
- Author(s)
  Yuko Ogo, Kenjiro Ozawa, Tsutomu Ishimaru, Tsugiya Murayama and Fumio Takaiwa
- Journal Title
  
  Plant Biotechnology Journal
  
  Volume: XX Pages: 1-13
- DOI
  10.1111/pbi.12064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Inhibitory Effects of Statins on Expression of Immediate-early 1 Protein of Human Cytomegalovirus in Virus-infected Cells.2013
- Author(s)
  H. Sadanari, T. Murayama, X. Zheng, R. Yamada, K. Matsubara, H. Yoshida, T. Takahashi
- Journal Title
  
  J Exp Clin Med
  
  Volume: 5 Pages: 187-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Quantitative regulation of peripheral leukocyte by light exercise and tailored scale for assessment.2013
- Author(s)
  N. Yamaguchi, R.Chen, K. Okamoto, T. Takei, M. Tsubokawa, D. Sakamoto, X.-F. Jia, W. Wu, T. Murayama
- Journal Title
  
  Open Journal of Immunology
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591492
[Journal Article] Herpes Simplex Virus Requires PARP Activity for Efficient Replication and Induces ERK-dependent Phosphorylation and ICP0-dependent Nuclear Localization of Tankyrase 12012
- Author(s)
  Li Z, Yamauchi Y, Kamakura M, et al
- Journal Title
  
  J. Virol
  
  Volume: (In press) Pages: 492-503
- DOI
  10.1128/jvi.05897-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390088, KAKENHI-PROJECT-24591492
[Journal Article] Anti-cytomegalovirus effects of tricin are dependent on CXCL11.2012
- Author(s)
  Murayama T, Li Y, Takahashi T, Yamada R, Matsubara K, Tsuchida Y, Zheng X, Sadanari H.
- Journal Title
  
  Microbes Infection
  
  Volume: 14 Pages: 1086-1092
- DOI
  10.1016/j.micinf.2012.05.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390306, KAKENHI-PROJECT-24591492
[Journal Article] Inhibitory effects of statins on cytomegalovirus production in human cells: comprehensive analysis of gene expression profiles2011
- Author(s)
  Murayama T, Bi C, Li Y, Ishigaki Y, Takano F, Takegami T, Ohta T, Sumino H, Ubukata K, Takahashi T
- Journal Title
  
  J Exp Clin Med
  
  Volume: 3 Pages: 40-45
- DOI
  10.1016/j.jecm.2010.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390306
[Journal Article] Inhibitory effects of statins on cytomegalovirus production in human cells : comprehensive analysis of gene expression profiles.2011
- Author(s)
  Tsugiya Murayama, Yasuhito Ishigaki, Takashi Takahashi, et al.
- Journal Title
  
  J Exp Clin Med
  
  Volume: VOL.3 Pages: 40-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390306
[Journal Article] Anti-cytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. ＆ Zehl.).2007
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy 18(accepted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Anti-cytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. ＆ Zehl.2007
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy 18(accepted)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Anti-cytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eck1. ＆ Zeh1.)2007
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy (accepted)
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Inhibition of ganciclovir-resistant human cytomegalovirus replication by Kampo (Japanese herbal medicine).2006
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Antiviral Chemistry & Chemotherapy 17
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Herpes virus-Drug resistance human cytomegalovirus.2006
- Author(s)
  Tsugiya Murayama
- Journal Title
  
  Nippon-rinsho 63(3)
  
  Pages: 508-511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] ヘルペスウイルス学-薬剤耐性HCMV-2006
- Author(s)
  村山次哉
- Journal Title
  
  日本臨床 63 (3)
  
  Pages: 508-511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] ヘルペスウイルス学-薬剤耐性HCMV-2006
- Author(s)
  村山次哉
- Journal Title
  
  日本臨床 64(3)
  
  Pages: 508-511
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Inhibition of ganciclovir-resistant human cytomegalovirus replication by Kampo (Japanese herbal medicine).2006
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Antiviral Chemistry ＆ Chemotherapy 17
  
  Pages: 11-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Analysis of human cytomegalovirus UL144 variability in low-passage clinical isolates in Japan.2005
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Intervirology 48(2-3)
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] Analysis of human cytomegalovirus UL144 variability in low-passage clinical isolates in Japan.2005
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  Intervirology 48
  
  Pages: 201-206
- Data Source
  KAKENHI-PROJECT-16591078
[Journal Article] In vitro anti-cytomegalovirus activity of Kampo (Japanese herbal) medicine2004
- Author(s)
  Tsugiya Murayama et al.
- Journal Title
  
  eCAM (Evidence-based Complementary and Alternative Medicine) 1(3)
  
  Pages: 285-289
- Data Source
  KAKENHI-PROJECT-16591078
[Patent] 化合物又はその塩、抗ウイルス剤、医薬組成物2017
- Inventor(s)
  村山次哉、土田裕三、藤本和宏、定成秀貴　他
- Industrial Property Rights Holder
  村山次哉、土田裕三、藤本和宏、定成秀貴　他
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K09587
[Patent] 化合物又はその塩、抗ウイルス剤、医薬組成物2017
- Inventor(s)
  村山次哉,土田裕三、二ノ宮真之、桜井大輔　他
- Industrial Property Rights Holder
  村山次哉,土田裕三、二ノ宮真之、桜井大輔　他
- Industrial Property Rights Type
  特許
- Filing Date
  2017-04-21
- Data Source
  KAKENHI-PROJECT-15K09587
[Patent] トリシンアミノ酸誘導体並びにそれを含む抗ウイルス剤及び抗癌剤2012
- Inventor(s)
  村山次哉,土田裕三、二ノ宮真之、桜井大輔　他
- Industrial Property Rights Holder
  村山次哉,土田裕三、二ノ宮真之、桜井大輔　他
- Industrial Property Rights Type
  特許
- Filing Date
  2012-05-31
- Acquisition Date
  2014-02-14
- Data Source
  KAKENHI-PROJECT-24591492
[Patent] 抗ウイルス剤2012
- Inventor(s)
  村山次哉、土田裕三、渡辺邦友、纐纈守、土田康太郎、桜井大輔
- Industrial Property Rights Holder
  村山次哉、土田裕三、渡辺邦友、纐纈守、土田康太郎、桜井大輔
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-16
- Acquisition Date
  2013-01-18
- Overseas
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] 抗ヒトサイトメガロウイルス活性のあるtricinがRNA polymerase II C-terminal domeinのリン酸化を阻害する2018
- Author(s)
  定成秀貴、杉原雄斗、藤本和宏、武本眞清、大黒　徹、村山次哉
- Organizer
  日本薬学会第１３8回年会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 超強力な抗ヒトサイトメガロウイルス活性を有する新規化合物について2018
- Author(s)
  根間大貴、藤本和宏、纐纈　守、二ノ宮真之、定成秀貴、武本眞清、大黒　徹、村山次哉
- Organizer
  日本薬学会第１３8回年会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] The novel compound shows potent anti-human cytomegalovirus activity2018
- Author(s)
  Tsugiya Murayama, Kazuhiro J. Fujimoto, Mamoru Koketsu, Masayuki Ninomiya, Hidetaka Sadanari, Masaya Takemoto, Tohru Daitoku
- Organizer
  5th International Congress on Technology, Engineering & Science
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] CCL5-dependent replication of human cytomegalovirus is inhibited by tricin in vitro.2018
- Author(s)
  T. Murayama, H. Sadanari, M. Takemoto, T. Daikoku
- Organizer
  18th International Congress on Infectious Diseases
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Novel compounds having potent anti-human cytomegalovirus activity2017
- Author(s)
  Tsugiya Murayama, Daiki Nema, Kazuhiro Fujimoto, Mamoru Koketsu, Masayuki Ninomiya, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku
- Organizer
  第65回日本ウイルス学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 日和見ウイルス感染症に対する新規治療薬の開発―作用機序に関する分子基盤機構の解明―2017
- Author(s)
  村山次哉
- Organizer
  北陸大学特別助成成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 超強力な抗ヒトサイトメガロウイルス活性を有する新規化合物2017
- Author(s)
  根間大貴、藤本和宏、二ノ宮真之、纐纈　守、杉原雄斗、定成秀貴、武本眞清、大黒　徹、村山次哉
- Organizer
  第２６回抗ウイルス療法学会総会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Inhibitory effect of tricin on CCL2-CCR2 dependent human cytomegalovirus replication.2017
- Author(s)
  Tsugiya Murayama, Hidetaka Sadanari, Masaya Takemoto, Keiko Matsubara, Tohru Daikoku
- Organizer
  16th international congenital CMV conference and 16th international CMV/betaherpesvirus workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 日和見ウイルス感染症に対する宿主因子依存性抗ウイルス薬の検索2017
- Author(s)
  赤井佑三子、定成秀貴、茂木香保里、武本眞清、松原京子、大黒　徹、村山次哉
- Organizer
  日本薬学会第１３７回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Inhibition of phosphorylation of RNA polymerase II C-terminal domein by anti-human cytomegalovirus drug tricin2017
- Author(s)
  Hidetaka Sadanari, Yuto Sugihara, Kazuhiro Fujimoto, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
- Organizer
  第65回日本ウイルス学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] CCL2/CCR2-dependent replication of human cytomegalovirus is inhibited by anti-inflammatory compound tricin2017
- Author(s)
  Tsugiya Murayama, Daiki Nema, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Naofumi Mukaida
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Sosiety
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 抗ヒトサイトメガロウイルス活性のあるtricinはcyclin-dependent kinase 9を阻害する2017
- Author(s)
  定成秀貴、杉原雄斗、藤本和宏、武本眞清、大黒　徹、村山次哉
- Organizer
  第２６回抗ウイルス療法学会総会
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Inhibition of host factor-dependent human cytomegalovirus replication by tricin2017
- Author(s)
  Tsugiya Murayama, Hidetaka Sadanari, Masaya Takemoto, Keiko Matsubara, Tohru Daikoku;
- Organizer
  2nd World Congress & Expo on Pharmaceutics & Drug Delivery Systems (Pharmaceutics- 2017)
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2017-03-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 話題の感染症とバイオテロリズム2016
- Author(s)
  村山次哉
- Organizer
  平成２８年度日本薬学図書館協議会研究集会
- Place of Presentation
  北陸大学
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] イネ科植物含有成分による宿主依存性抗ウイルス薬の検索2016
- Author(s)
  村山次哉
- Organizer
  日本薬学会北陸支部第１２８回例会
- Place of Presentation
  北陸大学薬学部
- Year and Date
  2016-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] インターフェロン誘導性遺伝子発現に対する抗ヒトサイトメガロウイルス活性のあるtricinの影響について2016
- Author(s)
  定成秀貴、茂木香保里、山田理恵、武本眞清、大黒　徹、村山次哉
- Organizer
  第６４回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 抗ヒトサイトメガロウイルス活性のあるtricinがインターフェロン誘導性遺伝子発現に影響を与える2016
- Author(s)
  茂木香保里、定成秀貴、武本眞清、大黒　徹、村山次哉
- Organizer
  第１９回日本補完代替医療学会学術集会
- Place of Presentation
  石川県文教会館
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] CCL5依存性ヒトサイトメガロウイルス増殖のtricinによる抑制効果2016
- Author(s)
  伊藤暁将、定成秀貴、山田理恵、松原京子、武本眞清、村山次哉
- Organizer
  第２６回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Inhibition of CCL2 dependent human cytomegalovirus replication by tricin.2016
- Author(s)
  Tsugiya Murayama, Rie Yamada, Keiko Matsubara, Hidetaka Sadanari
- Organizer
  17th International Congress on Infectious Diseases
- Place of Presentation
  Hyderabad, India
- Year and Date
  2016-03-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 抗炎症薬によるヒトサイトメガロウイルス複製の抑制2016
- Author(s)
  村山次哉、赤井佑三子、定成秀貴、山田理恵、武本眞清、大黒　徹
- Organizer
  第６４回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] 抗ヒトサイトメガロウイルス活性のあるtricinのインターフェロン誘導性遺伝子発現に対する影響について2016
- Author(s)
  茂木香保里、定成秀貴、山田理恵、松原京子、武本眞清、村山次哉
- Organizer
  第２６回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] イネ科植物含有成分によるヒトサイトメガロウイルスの増殖抑制効果2016
- Author(s)
  赤井佑三子、定成秀貴、武本眞清、大黒　徹、村山次哉
- Organizer
  第１９回日本補完代替医療学会学術集会
- Place of Presentation
  石川県文教会館
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] STATのリン酸化に対する抗ヒトサイトメガロウイルス活性のあるtricinの影響について2015
- Author(s)
  定成秀貴、武本眞清、山田理恵、村山次哉
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議センター
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] CCL2-CCR2 に依存したヒトサイトメガロウイルスの複製2015
- Author(s)
  村山次哉、三井田隆貴、山田理恵、定成秀貴、松原恵子
- Organizer
  第６３回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議センター
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K09587
[Presentation] Tricinと抗ヒトサイトメガロウイルス薬による併用効果2014
- Author(s)
  山田理恵、定成秀貴、土田裕三、村山次哉
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] ヒトサイトメガロウイルス（HCMV）の初期―後期遺伝子と後期遺伝子のプロモーター活性を利用した抗HCMV剤検索検索システムの可能性2013
- Author(s)
  定成秀貴、長尾嘉真、三谷逸人、安井真一、山田理恵、村山次哉
- Organizer
  第６１回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Ganciclovirとtricinによる抗ヒトサイトメガロウイルス作用の検討2013
- Author(s)
  山田理恵、須田英揮、馬場昌範、土田裕三、定成秀貴、村山次哉
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] クマザサ含有成分“Tricin”による抗ヒトサイトメガロウイルス作用機序の検討2013
- Author(s)
  菊池万里絵、山田理恵、定成秀貴、松原恵子、土田裕三、村山次哉
- Organizer
  第１６回日本補完代替医療学会学術集会
- Place of Presentation
  金沢勤労者プラザ
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Ganciclovirとtricin併用による抗ヒトサイトメガロウイルス作用機序の検討2013
- Author(s)
  山田理恵、土田裕三、定成秀貴、村山次哉
- Organizer
  第１６回日本補完代替医療学会学術集会
- Place of Presentation
  金沢勤労者プラザ
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] ヒトサイトメガロウイルス（HCMV）の初期―後期遺伝子と後期遺伝子のプロモーター活性を利用した抗HCMV剤検索検索システムの構築2013
- Author(s)
  定成秀貴、長尾嘉真、三谷逸人、安井真一、山田理恵、村山次哉
- Organizer
  第２３回日本抗ウイルス療法研究会総会
- Place of Presentation
  リーガロイヤルホテル東京
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] CXCL11-dependent anti-cytomegalovirus effects of tricin2012
- Author(s)
  Tsugiya Murayama,Ying Li, Yuuzo Tuchida, Takashi Takahashi, Rie Yamada, Hidetaka Sadanari
- Organizer
  14th International CMV/Betaherpesvirus workshop
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Inhibitory effects of simvastatin on human cytomegalovirus replication through altered expression of a chemokine, C-X-C motif ligand 11 in human embryonic lung cells2012
- Author(s)
  Takashi Takahashi, Tsugiya Murayama, Ying Li, Rie Yamada, Keiko Matsubara, Xin Zheng, Hidetaka Sadanari
- Organizer
  The 11th East Asian Conference on Infection Control and Prevention
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Ganciclovirとtricinによる抗ヒトサイトメガロウイルス作用の相乗効果2012
- Author(s)
  村山次哉、須田英揮、馬場昌範、土田裕三、山田理恵、定成秀貴
- Organizer
  第６０回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Action mechanisms of tricin on anti-cytomegalovirus effect2012
- Author(s)
  Tsugiya Murayama, Yuuzo Tuchida, Rie Yamada, Hidetaka Sadanari, Keiko Matsubara
- Organizer
  25rd International conference on antiviral research
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] ヒトサイトメガロウイルス（HCMV）の初期―後期遺伝子と後期遺伝子のプロモーター活性を利用した抗HCMV剤検索システムの検討2012
- Author(s)
  定成秀貴、長尾嘉真、三谷逸人、安井真一、山田理恵、村山次哉
- Organizer
  第６０回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Inhibitory effects of simvastatin on human cytomegalovirus replication through altered expression of a chemokine, C-X-C motif ligand 11 in human embryonic lung cells.2012
- Author(s)
  Takashi Takahashi, Tsugiya Murayama, et al. (Takashi Takahashi)
- Organizer
  11th East Asian Conference on Infection Control and Prevention
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] ヒトサイトメガロウイルス（HCMV）に対する抗ウイルス剤検索に利用可能なHCMV遺伝子の検討2012
- Author(s)
  定成秀貴、長尾嘉真、三谷逸人、安井真一、山田理恵、村山次哉
- Organizer
  第49回日本細菌学会中部支部総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Inhibitory effect of statins on expression of the major immediate-early gene of human cytomegalovirus (HCMV) in HCMV-infected cells2011
- Author(s)
  Sadanari H, (Murayama T)
- Organizer
  International Union of Microbiological Societies 2011 congress
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] Tricin、4', 5, 7-trihydroxy-3', 5'-dimethoxyflavoneによる抗ヒトサイトメガロウイルス効果の機序について2011
- Author(s)
  李瑩, (村山次哉)
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡市, 静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] Inhibitory effects of various statins on cytomegalovirus replication in human cells.2010
- Author(s)
  Takashi Takahashi, Tsugiya Murayama, Yasuhito Ishigaki, et al.
- Organizer
  50^<th> Annual Meeting of ICAAC
- Place of Presentation
  Boston, USA
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] スタチン系薬剤による抗ヒトサイトメガロウイルス作用の検討2010
- Author(s)
  瑩, (村山次哉)
- Organizer
  日本薬学会第130 年会
- Place of Presentation
  岡山, 岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] スタチン系薬剤による抗ウイルス効果の検討2009
- Author(s)
  李瑩, (村山次哉)
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  千代田区, 東京
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] スタチン系薬剤のヒトサイトメガロウイルスに対する増殖抑制効果2009
- Author(s)
  畢長暁, (村山次哉)
- Organizer
  日本薬学会北陸支部第120回例会
- Place of Presentation
  金沢, 石川
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] スタチン系薬剤による抗ウイルス効果の検討2009
- Author(s)
  李瑩、高橋孝、村山次哉, 他
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京都)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21390306
[Presentation] TricinのCXCL11介在性抗ヒトサイトメガロウイルス作用
- Author(s)
  山田理恵、定成秀貴、土田裕三、村山次哉
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] ヒトサイトメガロウイルスのUL100遺伝子の転写調節領域の解析
- Author(s)
  松浦純児、定成秀貴、山田理恵、村山次哉
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  北陸大学薬学部
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] Tricinの抗ヒトサイトメガロウイルス作用におけるケモカインCXCL-11の関与
- Author(s)
  古谷田陽子、山田理恵、土田裕三、定成秀貴、村山次哉
- Organizer
  第１７回日本補完代替医療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] イネ科植物含有成分“Tricin”による抗ヒトサイトメガロウイルス作用機序の解明
- Author(s)
  三井田隆貴、山田理恵、松原恵子、定成秀貴、村山次哉
- Organizer
  第１７回日本補完代替医療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] CCL2-CCR2 dependent-human cytomegalovirus replication.
- Author(s)
  Tsugiya Murayama, Marie Kikuchi, Takaki Miita, Rie Yamada, Hidetaka Sadanari, Yoshito Eizuru
- Organizer
  . 5th International congenital CMV conference and 15th International CMV/Beta herpes virus workshop
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2015-04-20 – 2015-04-24
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] A cell-based assay using a human cytomegalovirus (HCMV) late promoter-luciferase reporter for identifying inhibitors of HCMV replication.
- Author(s)
  Hidetaka Sadanari, Rie Yamada, Keiko Matsubara, Tsugiya Murayama
- Organizer
  The 39th Annual international herpesvirus workshop
- Place of Presentation
  Kobe, Japan
- Year and Date
  2014-07-19 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-24591492
[Presentation] CXC chemokin-dependent cytomegalovirus replication.
- Author(s)
  Tsugiya Murayama, Hidetaka Sadanari, Ying Li, Rie Yamada, Keiko Matsubara
- Organizer
  The 39th Annual international herpesvirus workshop
- Place of Presentation
  Kobe, Japan
- Year and Date
  2014-07-19 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-24591492

1. EIZURU Yoshito (00041351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OBUCHI Masatsugu (70257450)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. SADARARI Hidetaka (60121274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
4. OHARA Yoshiro (50203914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAHASHI Takashi (00292855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. ISHIGAKI Yasuhito (20232275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TAKANO Fumihide (20236251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 宮本謙一 (30100514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 野村政明 (20247480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 横川弘一 (50283122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMADA Rie

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
12. FUJIMOTO Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. TAKEMOTO Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 鎌倉真紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 大黒徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 栄鶴義人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MURAYAMA Tsugiya 村山 次哉

Research Projects

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Co-Researchers

Study of the molecular mechanisms of novel therapeutic candidate for cytomegalovirus infectionPrincipal Investigator

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Analysis of molecular mechanisms of new anti-virus drug against human cytomegalovirus infectious diseasesPrincipal Investigator

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Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections

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Studies on virulence of new gene products of cytomegalovirusPrincipal Investigator

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微小環境における腫瘍細胞の悪性誘導機序の解析と制御

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Molecular mechanisms of IL-8 gene expression by the immediate early gene products of cytomegelovirusPrincipal Investigator

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Theiler's virus as a vector for foreign gene delivery into the CNS

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Molecular mechanisms for enhancement of human cytomegalovirus replication by chemokine, interleukin 8Principal Investigator

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[Book] “化学療法の領域、特集・飛躍的に発展を見せる抗ウイルス薬”2017

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[Book] 応用細胞補完代替医療学2012

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[Journal Article] The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9.2018

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[Journal Article] An in silico-designed flavone derivative, 6-fluoro-4′-hydroxy-3′,5′-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells2018

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DOI

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[Journal Article] クマザサ含有成分によるCCL2依存性のヒトサイトメガロウイルス増殖抑制効果2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] CCL2/CCR2-dependent replication of human cytomegalovirus is inhibited by anti-inflammatory compound tricin.2017

Author(s)

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[Journal Article] Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression.2017

MURAYAMA Tsugiya 村山次哉