NAKAMURA Hirotoshi 中村浩淑

Researcher Number	60164331
External Links
Affiliation (based on the past Project Information) *help	2008 – 2010: Hamamatsu University School of Medicine, 医学部, 教授 2004: Hamamatsu Univ., 2nd Div.Int.Medicine, Professor, 医学部, 教授 2000 – 2004: 浜松医科大学, 医学部, 教授 2002: Hamamatsu University School of medicine, professor, 医学部, 助手 1997: Hamamatsu University School of Medicine, Professor of Medicine, 医学部, 教授 … More 1996: 浜松医科大学, 医学部附・属病院, 講師 1995: 浜松医科大学, 医学部・附属病院, 講師 1993 – 1994: 浜松医科大学, 医学部, 講師 1991 – 1993: 京都大学, 医学部, 助手 1986 – 1989: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Respiratory organ internal medicine / Endocrinology / Respiratory organ internal medicine Except Principal Investigator Endocrinology / Metabolomics / Endocrinology / 内分泌・代謝学
Keywords	Principal Investigator 甲状腺ホルモン不応症 / 甲状腺ホルモン / CD36 / two hybrid system / トランスジェニックマウス / 肺癌 / レチノイン酸受容体 / ビタミンD受容体 / ドミナントネガティブ作用 / ドミナントネガチブ作用 … More / 遺伝子異常 / 甲状腺ホルモン受容体 / c-erbA / Receptor antibody / C-erb A / Hormone action / Thyroid hormone receptor / Thyroid hormone / レセプター数の変動 / FRT細胞 / c-erb Aレセプター抗体 / 甲状腺細胞 / レセプター抗体 / c-erb A / ホルモン作用 / 甲状腺ホルモンレセプター / anti-inflammation / pcroxisome proliferator-activated receptor (PPAR)γ / nuclear receptor / lung cancer / sarcoidosis / 25-hydroxyvitainin D3 lα-hydroxylase / alveolar macropharge / PPARγ / 1αhydroxylase / peroxisome proliferator-activated receptor (PPAR)γ / 25-hydroxyvitamin D3 1α-hydroxylase / peroxisome proliferator-activated receptor(PPAR)γ / 核内ホルモン受容体 / サルコイドーシス / 25-hydroxyvitamin D3 1 α-hydroxylase / 肺胞マクロファージ / vitamin D receptor / dominant negative effect / silencing activity / transgenic mouse / thyroid hormone receptor / 酵母two hybrid system / ダイマー形成 / サイレンシング作用 / 心筋 / 転写調節 / 骨格筋 / 下垂体 / 脱ヨード酵素 / サーファクタントC遺伝子 / Cre-LoxP系発現ベクター / 優位阻害作用 / レチノイン酸 / 転写抑制作用 / レプレッサー作用 / 遺伝子転写制御 / 異常T3受容体 / 全身型不応症 / 下垂体型不応症 / 転写活性 / 異常甲状腺ホルモンレセプター / レセプター異常症 / HL-60細胞 / 点突然変異 / 遺伝子解析 / ウエスタンブロッティング分析 / 甲状腺ホルモンレセプタ- / レセプタ-抗体 … More Except Principal Investigator Pit1 / GATA2 / 甲状腺ホルモン受容体 / PPAR-γ / transcriptional regulation / 甲状腺刺激ホルモン / 甲状腺ホルモン / 転写調節 / nuclear hormone receptor / pituitary / thyroid hormone receptor / thyroid hormone / TSH / 核内受容体 / 下垂体 / インスリン抵抗性 / 脂肪細胞 / negative regulation / high mobility group (HMG) protein / thyrotropin β (TSHβ) / thyroid hormone receptor (TR) / thyroid hormone (T3) / ネガティブフィードバック / 転写 / 負の調節(Negative regulation) / pit1 / high mobility group蛋白(HMG) / 甲状腺刺激ホルモンβ(TSHβ) / 甲状腺ホルモン受容体(TR) / 甲状腺ホルモン(T3) / Point Mutation / Map Kinase / Resistance to Thyroid Hormone / Thyroid Hormone Receptor / Endothelin-B Receptor / Natriuretic Peptide Receptors / Insulin Signal Transduction / Insulin Receptor / インスリンレセプタ- / バセドウ病 / TSHレセプタ- / 甲状腺ホルモン・レセプタ- / エンドセリン・レセプタ- / エンドセリン受容体遺伝子 / エンドセリン受容体 / エンドセリン / インスリン受容体後異常 / 点突然変異 / MAPキナーゼ / 甲状腺ホルモン不応症 / 甲状腺ホルモンレセプター / エンドセリンB・レセプター / ナトリウム利尿ペプチドレセプター / インスリン・シグナル伝達 / インスリン・レセプター / EGFレセプター / EGF / 癌遺伝子 / 腫瘍マーカー / 単クローン抗体 / CRF / ACTH / ホルモン / ドミナントネガティブ作用 / 甲状腺機能低下症 / 甲状腺低形成 / トランスジェニックマウス Less

Molecular mechanism of the type 2 deiodinase gene transcriptionPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hirotoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
甲状腺特異的な異常甲状腺ホルモン受容体発現トランスジェニックマウスの機能解析
- Principal Investigator
  
  NISHIYAMA Kozo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
優位阻害型レチノイン酸受容体の肺特異的、時相特異的発現マウスの開発Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hamamatsu University School of Medicine
Negative regulation of thyroid stimulating hormone α and β subunit genes by thyroid hormone and its receptor
- Principal Investigator
  
  SASAKI Shigekazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
The role of PPAR-γ on the adipocyte differentiation and the improvement of insulin resistance
- Principal Investigator
  
  MORITA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hamamatsu University School of Medicine
THE STUDY OF THE EXPRESSIONS AND FUNCTIONS OF NUCLEAR HORMONE RECEPTORS IN HUMAN ALVEOLAR MACROPHAGESPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hirotoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hamamatsu University School of Medicine
The study of the negative regulation of thyrotropin b by thyroid hormone and its receptor
- Principal Investigator
  
  SASAKI Shigekazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
THE STUDY OF THE FUNCTIONS AND EXPRESSIONS OF WILD-TYPE AND MUTANT THYROID HORMONE RECEPTORSPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hirotoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hamamatsu University School of Medicine
C端欠失異常T3受容体の示す強力な転写抑制および阻害作用に関する研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hamamatsu University School of Medicine
異常甲状腺ホルモンレセプターの転写活性阻害機構に関する研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hamamatsu University School of Medicine
甲状腺ホルモン受容体遺伝子異常の発現と機能に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Hamamatsu University School of Medicine
正常および異常甲状腺ホルモン受容体の発現と機能に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
甲状腺ホルモンレセプタ-の発現と機能に関する分子生物学ならびに免疫組織化学的研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Functional and pathophysiological analyzes of hormone receptors
- Principal Investigator
  
  TANAKA Issei, 葛谷英嗣, 井村裕夫
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
レセプタ-抗体を用いた甲状腺ホルモン核レセプタ-の分析に関する研究Principal Investigator
- Principal Investigator
  
  中村浩淑
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Research on the Mechanism of thyroid hormone actionPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Hirotoshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
ホルモン及びその他の腫瘍抗原の診断及び治療への応用に関する研究
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University

All 2011 2010 2009 2008 2007 2005 2004 2003

All Journal Article Presentation

[Journal Article] Unliganded thyroid hormone receptor-β1 represses liver X receptor α/oxysterol-dependent transactivation2005
- Author(s)
  Kawai K, Sasaki S, Morita H, Ito T, Nakamura H.
- Journal Title
  
  Endocrinology 145
  
  Pages: 5515-5524
- Data Source
  KAKENHI-PROJECT-15659196
[Journal Article] Thyroid hormone-dependent negative regulation of thyrotropin β gene by thyroid hormone receptors2004
- Author(s)
  Nakano K, Matsushita A, Sasaki S, Misawa H, Nishiyama, Nakamura H
- Journal Title
  
  Biochem J 378
  
  Pages: 549-557
- Data Source
  KAKENHI-PROJECT-15659196
[Journal Article] The loss of retinoic acid receptor α,β and alcohol dehydrogenase3 expression in non-small cell lung cancer2003
- Author(s)
  Inui N, Sasaki S, Suda T, Chida K, Nakamura H
- Journal Title
  
  Respirology 8
  
  Pages: 302-309
- Data Source
  KAKENHI-PROJECT-15659196
[Journal Article] Anti-inflammatory roles of peroxisome proliferator-activated receptor gamma in human alveolar macrophages2003
- Author(s)
  Asada K, Sasaki S, Suda T, Chida K, Nakamura H
- Journal Title
  
  AM J Respir Crit Care Med 169(2)
  
  Pages: 195-200
- Data Source
  KAKENHI-PROJECT-15659196
[Journal Article] Increased expression of the 25-hydroxyvitamin D3-1 α-hydroxylase gene in alveolar macrophages of patients with lung cancer2003
- Author(s)
  Yokomura K, Suda Y, Sasaki S, Inui N, Chida K, Nakamura H
- Journal Title
  
  J Clin Endocrinol Metab 88
  
  Pages: 5704-5709
- Data Source
  KAKENHI-PROJECT-15659196
[Journal Article] High expression of Cks1 in human non-small cell lung carcinomas2003
- Author(s)
  Inui N, Kitagawa K, Miwa S, Hattori T, Chida K, Nakamura H, Kitagawa
- Journal Title
  
  Biochem Biophys Res Commun 303(3)
  
  Pages: 978-984
- Data Source
  KAKENHI-PROJECT-15659196
[Presentation] 2型脱ヨード酵素遺伝子の転写調節においてGATA2とPKAは相乗的に作用する2011
- Author(s)
  松永英之、佐々木茂和、松下明生、大場健司、岩鬼裕之、鈴木伸吾、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第84回日本内分泌学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] GATA2はthyrotrophにおける2型脱ヨード酵素の発現を制御する2010
- Author(s)
  松永英之、佐々木茂和、松下明生、大場健司、岩鬼裕之、鈴木伸吾、松永英之、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第53回日本甲状腺学会総会(若手奨励賞受賞演題)
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] 骨格筋における2型脱ヨード酵素の発現調節機構の検討2010
- Author(s)
  鈴木伸吾、佐々木茂和、松下明生、大場健司、岩鬼裕之、松永英之、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第53回日本甲状腺学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] GATA2 regulates the transcription of type 2 deiodinase in thyrotroph.2009
- Author(s)
  松永英之, 佐々木茂和, 松下明生, 大場健司, 岩鬼裕之, 鈴木伸吾, 三沢啓子, 石塚惠子,中村浩淑
- Organizer
  The 9th Congress of the Asia and Oceania Thyroid Association
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] 2型脱ヨード酵素遺伝子の転写調節におけるGATA2の意義2009
- Author(s)
  松永英之、佐々木茂和、松下明生、大場健司、岩鬼裕之、鈴木伸吾、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第82回日本内分泌学会総会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] 心筋における2型脱ヨード酵素の発現調節機構の検討-転写因子GATA2の意義2009
- Author(s)
  鈴木伸吾、佐々木茂和、松下明生、大場健司、岩鬼裕之、松永英之、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第52回日本甲状腺学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] T3/T3受容体による2型脱ヨード酵素遺伝子の転写制御機構2008
- Author(s)
  松永英之、佐々木茂和、松下明生、大場健司、岩鬼裕之、鈴木伸吾、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第51回日本甲状腺学会総会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] 甲状腺ホルモン(T3)による2型脱ヨード酵素の転写調節機構におけるGATA2の意義2008
- Author(s)
  松永英之、佐々木茂和、松下明生、長山浩士、大場健司、岩鬼裕之、鈴木伸吾、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第81回日本内分泌学会総会
- Place of Presentation
  弘前
- Data Source
  KAKENHI-PROJECT-20591092
[Presentation] 2型脱ヨード酵素遺伝子転写調節機序:GATA2の重要性2007
- Author(s)
  松永英之、佐々木茂和、松下明生、大場健司、岩鬼裕之、鈴木伸吾、三沢啓子、石塚恵子、中村浩淑
- Organizer
  第50回日本甲状腺学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591092

1. SASAKI Shigekazu (20303547)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
2. SUDA Takafumi (30291397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. NISHIYAMA Kozo (50273181)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 井村裕夫 (10025570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 森徹 (40026894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 葛谷英嗣 (20115835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TANAKA Issei (80179738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAO Kazuwa (00172263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORITA Hiroshi (20293631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 阿部薫 (60076990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 福田善弘 (50127130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中井義勝 (10115892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAMURA Hirotoshi 中村 浩淑

Research Projects

Research Products

Co-Researchers

Molecular mechanism of the type 2 deiodinase gene transcriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

甲状腺特異的な異常甲状腺ホルモン受容体発現トランスジェニックマウスの機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

優位阻害型レチノイン酸受容体の肺特異的、時相特異的発現マウスの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Negative regulation of thyroid stimulating hormone α and β subunit genes by thyroid hormone and its receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of PPAR-γ on the adipocyte differentiation and the improvement of insulin resistance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE STUDY OF THE EXPRESSIONS AND FUNCTIONS OF NUCLEAR HORMONE RECEPTORS IN HUMAN ALVEOLAR MACROPHAGESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of the negative regulation of thyrotropin b by thyroid hormone and its receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE STUDY OF THE FUNCTIONS AND EXPRESSIONS OF WILD-TYPE AND MUTANT THYROID HORMONE RECEPTORSPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C端欠失異常T3受容体の示す強力な転写抑制および阻害作用に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

異常甲状腺ホルモンレセプターの転写活性阻害機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

甲状腺ホルモン受容体遺伝子異常の発現と機能に関する分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

正常および異常甲状腺ホルモン受容体の発現と機能に関する分子生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

甲状腺ホルモンレセプタ-の発現と機能に関する分子生物学ならびに免疫組織化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

NAKAMURA Hirotoshi 中村浩淑