HORINOUCHI Hirohisa 堀之内宏久

Researcher Number	60173647
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2006 – 2012: 慶應義塾大学, 医学部, 准教授 2011: 慶應義塾大学, 医学部・外科, 准教授 1999 – 2006: 慶應義塾大学, 医学部, 講師 1998: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Thoracic surgery / Thoracic surgery Except Principal Investigator Thoracic surgery / General surgery / Thoracic surgery
Keywords	Principal Investigator 腫瘍循環 / 人工酸素運搬体 / 血管新生 / 癌 / 低酸素 / angiogenesis / 組織酸素分圧 / 放射線治療 / 酸素消費率 / oxymetry … More / hypoxia / tumor microcirculation / cancer / 腫瘍内酸素分圧 / 腹水肝癌 / 組織酸素分圧測定 / Interstitial matrix / Heparan sulphate proteoglycan / lung metastasis / heparanase / ヘパリナーゼ / 腫瘍内血管密度 / ヘパラナーゼ / ヘパラン硫酸プロテオグリカン / 間質組織 / プロテオグリカン / 肺転移 / Heparanase活性 / laser confocal microscope / nitric oxide / Hemogobin-Vesicle / artificialoxygen carrier / pulmonary microcirculation / lung neoplasm / metastasis / 肺微少循環 / 肺微小循環 / 共焦点レーザー顕微鏡 / 一酸化窒素 / 微小循環 / 肺循環 / 転移性肺腫瘍 / 酸素ガス / 細動脈 / 酸素拡散係 / 低酸素状態 / 酸素拡散係数 / 放射線治寮 … More Except Principal Investigator artificial oxygen carrier / 人工酸素運搬体 / LY-80 / ラット / CYFRA / chemotherapy / 放射線療法 / 腫瘍の酸素化 / 肺癌 / tumor irradiation / tumor perfusion / tumor oxygenation / 腎腫瘍 / 酸素代謝 / 放射線照射 / 腫瘍潅流 / 腫瘍酸素化 / radiation / Ly-80 / tumor / rat / 補助科学療法 / 動脈内注入 / 腫瘍循環 / 腫瘍内酸素分圧 / LK-80 / 抗癌剤 / 腫瘍 / CEA / tumor marker / microsampling method / bronchoscopy / lung cancer / シフラ / 腫瘍コーカー / 腫瘍マーカー / マイクロサンプリング法 / 気管支鏡 / increment of sensitivity / drug sensitivity test / oxygenations of tumors / 腫瘍細胞の酸素化 / 化学療法 / 感受性の増強 / 抗癌剤感受性試験 / 呼吸器外科 / 移植・再生医療 / 転移 / がん / 呼吸器外科学 / ストローマ細胞 / がん転移 Less

悪性腫瘍の低酸素環境調節因子としての細動脈での酸素拡散・消費に関する検討Principal Investigator
- Principal Investigator
  
  堀之内宏久
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Application of hemoglobin vesicles for lung transplantation
- Principal Investigator
  
  KOHNO Mitsutomo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Analysis of oxygen transport to malignant tumor and mechanism of enhancing effect of treatment by oxygenation of tumor tissuePrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Hirohisa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Enhanced radiation response andn inhibition of angiogenesis by artificial oxygen carrierPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Hirohisa
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Lung cancer cells metastasize together with tumor-derived host cells
- Principal Investigator
  
  KOHNO Mitsutomo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Control of angiogenesis by attenuation of oxygen tension in the metastatic tumor of the lungPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Hirohisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Changes in oxygen metabolism in solid tumors by administration of artificial oxygen carriers
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Analysis of metastasis mechanism in experimental lung metastasis with heparanase transgenic tumor cellsPrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Hirohisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KEIO UNIVERSITY
Analysis of microcirculation of experimental metastatic lung tumor using artificial oxygen carrier as a tool for altering the microvascular tonePrincipal Investigator
- Principal Investigator
  
  HORINOUCHI Hirohisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Bronchoscopic microsampling method for the diagnosis of small lung cancer
- Principal Investigator
  
  WATANABE Masazumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Tumor oxygenation to in crease sensitivity to anti-cancerous drug by using artificial oxygen carrier
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  Keio University

All 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] MOOK肺癌の臨床疫学・病理・発見・診断・治療2006-2006/高齢者肺癌の外科治療2006
- Author(s)
  堀之内宏久, 小林紘一
- Total Pages
  471
- Publisher
  篠原出版新社
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Removal of cellular-type hemoglobin-based oxygen carrier(hemoglobin-vesicles) from blood using centrifugation and ultrafiltration2012
- Author(s)
  Sakai H, Sou K, Horinouchi H, Tsuchida E, Kobayashi K
- Journal Title
  
  Artif Organs
  
  Volume: 36(2) Pages: 202-9
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] A new method for measuring the oxygen diffusion constant and oxygen consumption rate of arteriolar walls2012
- Author(s)
  Sasaki N, Horinouchi H, Ushiyama A, Minamitani H
- Journal Title
  
  Keio J Med
  
  Volume: (in press)
- NAID
  10030771368
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Spatiotemporal measurement of tumor oxygeneation reveals repeat hypoxic phenomenon in mice2011
- Author(s)
  Yamada R, Horinouchi H, Tsukada K
- Journal Title
  
  Conf Proc IEEE Eng Med Biol Soc
  
  Volume: 2011 Pages: 5965-5968
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Hemoglobin vesicle improves recovery of cardiac function after ischemia-reperfusion by attenuating oxidative stress in isolated rat hearts2011
- Author(s)
  Nakajima J, Bessho M, Adachi T, Yamagishi T, Tokuno S, Horinouchi H, Ohsuzu F
- Journal Title
  
  J. Cardiovasc Pharmacol
  
  Volume: 58(5) Pages: 528-34
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation.2009
- Author(s)
  Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K.
- Journal Title
  
  J Surg Res. (Epub 2008 Jan 17) 151(1)
  
  Pages: 48-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591410
[Journal Article] Review of hemoglobinvesicles as artificial oxygen carriers2009
- Author(s)
  Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E.
- Journal Title
  
  Artif Organs 33
  
  Pages: 139-145
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model2009
- Author(s)
  Sakai H, Horinouchi H , Tsuchida E, Kobayashi K.
- Journal Title
  
  Shock 31
  
  Pages: 507-514
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model2009
- Author(s)
  Sakai H, Horinouchi H, Tsuchida E, Kobayashi K
- Journal Title
  
  Shock
  
  Volume: 31 Pages: 507-14
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Review of hemoglobin-vesicles as artificial oxygen carriers2009
- Author(s)
  Sakai H, Sou K, Horinouchi H, Kobayashi K, Tsuchida E
- Journal Title
  
  Artif Organs
  
  Volume: 33(2) Pages: 139-45
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation2009
- Author(s)
  Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K
- Journal Title
  
  J Surg Res 151
  
  Pages: 48-54
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591410
[Journal Article] Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model2009
- Author(s)
  Taguchi K, Maruyama T, Iwao Y, Sakai H, Kobayashi K, Horinouchi H, Tsuchida E, Kai T, Otagiri M
- Journal Title
  
  J Control Release
  
  Volume: 136 Pages: 232-9
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Histopathological changes of rat brain after direct injection of Hb-vesicles(artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model2009
- Author(s)
  Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E
- Journal Title
  
  J Biomed Mater Res A
  
  Volume: 90 Pages: 1107-19
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] A transient inflammatory reaction in the lung after experimental hemorrhagic shock and resuscitation with a hemoglobin-vesicles solution compared with rat RBC transfusion2009
- Author(s)
  Yamanashi Y, Mori M, Terajima K, Tsueshita T, Horinouchi H, Sakai H, Sakamoto A
- Journal Title
  
  ASAIO J.
  
  Volume: 55(5) Pages: 478-83
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme'2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
- Journal Title
  
  Cancer Sci.(Epub 2008 Apr 21) 99(6)
  
  Pages: 1274-1278
- NAID
  10024007807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model2008
- Author(s)
  Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E.
- Journal Title
  
  J Biomed Mater Res A.(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma2008
- Author(s)
  Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, Watanabe M, Kawamura M, Horinouchi H, Shimada N, Kobayashi K, Sakamoto M.
- Journal Title
  
  Mod Pathol.(Epub 2008 May 30) 21(8)
  
  Pages: 992-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model2008
- Author(s)
  Sakai H, Okamoto M, Ikeda E, Horinouchi H, Kobayashi K, Tsuchida E.
- Journal Title
  
  J Biomed Mater Res A.(Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme'.2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
- Journal Title
  
  Cancer Sci. 99(6) (Epub 2008 Apr 21)
  
  Pages: 1274-8
- NAID
  10024007807
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591410
[Journal Article] Structure, photophysical property, and cytotoxicity of human serum albumin complexed with tris(dicarboxymethylene)[60]fullerene2008
- Author(s)
  Qu X, Komatsu T, Sato T, Glatter O, Horinouchi H, Kobayashi K, Tsuchida E.
- Journal Title
  
  Bioconjug Chem.(Epub 2008 Jul 22) 19(8)
  
  Pages: 1556-1560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme'2008
- Author(s)
  Horinouchi H , Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
- Journal Title
  
  Cancer Sci.(Epub 2008 Apr 21.) 99(6)
  
  Pages: 1274-1278
- NAID
  10024007807
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation2008
- Author(s)
  Yamamoto M, Izumi Y, Horinouchi H , Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K.
- Journal Title
  
  JSurg Res(Epub 2008Jan 17) 151(1)
  
  Pages: 48-54
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme'.2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
- Journal Title
  
  Cancer Science 99
  
  Pages: 1274-8
- NAID
  10024007807
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591410
[Journal Article] Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine2008
- Author(s)
  Kuroda H, Kawamura M, Hato T, Kamiya K, Kawakubo M, Izumi Y, Watanabe M, Horinouchi H, Kobayashi K, Nakayama M.
- Journal Title
  
  Cancer Chemother Pharmacol 62(2)
  
  Pages: 331-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Systemic Administration of Hemoglobin Vesicle Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation2008
- Author(s)
  Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K.
- Journal Title
  
  JSurg Res 2008(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Enhanced radiation response of a solid tumor with the a rtificial 0xygen carrier'albumin-heme'.2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K.
- Journal Title
  
  Cancer science 99
  
  Pages: 1274-1278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Systemic Administration of Hemoglobin Vesicle Elevates Tumor Tissue Oxygen Tension and Modifies Tumor Response to Irradiation.2008
- Author(s)
  Yamamoto M, Izumi Y, Horinouchi H, Teramura Y, Sakai H, Kohno M, Watanabe M, Kawamura M, Adachi T, Ikeda E, Takeoka S, Tsuchida E, Kobayashi K
- Journal Title
  
  J Surg Res E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] An enhanced radiation response of solid tumor with the artificial oxygen carrier"allbumin-heme"(rHSA-FeP)2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Huang Y, Tsuchida E, Kobayashi K
- Journal Title
  
  Cancer Science 99(6)
  
  Pages: 1274-1278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] 縦隔へ向かって発育を示した鎖骨原発軟骨肉腫の1例2007
- Author(s)
  江間俊哉, 江口圭介, 井澤菜緒子, 高橋祐介, 池田達彦, 朝倉啓介, 塚田紀理, 河野光智, 泉陽太郎, 渡辺真純, 堀之内宏久, 川村雅文, 小林紘一
- Journal Title
  
  日本呼吸器外科学会雑誌 21
  
  Pages: 850-853
- NAID
  110006452377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] 縦隔へ向かって発育を示した鎖骨原発軟骨肉腫の1例2007
- Author(s)
  江間俊哉, 江口圭介, 井澤菜緒子, 高橋祐介, 池田達彦, 朝倉啓介, 塚田紀理, 河野光智, 泉陽太郎, 渡辺真純, 堀之内宏久, 川村雅文, 小林紘一
- Journal Title
  
  日本呼吸器外科学会雑誌 21巻6号
  
  Pages: 850-853
- NAID
  110006452377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Haemoglobin-vesicles as artificial oxygen carriers : present situation and future visions2007
- Author(s)
  Sakai H, Sou K, Horinouchi H , Kobayashi K, Tsuchida E.
- Journal Title
  
  J Intern Med(Epub 2007 Nov 27. Review) 263
  
  Pages: 4-15
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] One-year observation of Wistar rats after intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers)2007
- Author(s)
  Sakai H, Tsuchida E, Horinouchi H , Kobayashi K.
- Journal Title
  
  Artif Cells Blood Substit Immobil Biotechnol 35(1)
  
  Pages: 81-91
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Influence of O(2)-carrying plasma hemoprotein "albumin-heme" on complement system and platelet activation in vitro and physiological responses to exchange transfusion2007
- Author(s)
  Komatsu T, Huang Y, Wakamoto S, Abe H, Fujihara M, Azuma H, Ikeda H, Yamamoto H, Horinouchi H , Kobayashi K, Tsuchida E.
- Journal Title
  
  J Biomed Mater Res A. 81(4)
  
  Pages: 821-826
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Effect of hemoglobin vesicle, a cellular-type artificial oxygen carrier, on middle cerebral artery occlusion- and arachidonic acid-induced stroke models in rats2007
- Author(s)
  Komatsu H, Furuya T, Sato N, Ohta K, Matsuura A, Ohmura T, Takagi S, Matsuura M, Yamashita M, Itoda M, Itoh J, Horinouchi H , Kobayashi K.
- Journal Title
  
  Neurosci Lett(Epub 2007 Jun 2) 421(2)
  
  Pages: 121-125
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] 術前化学療法後に外科的切除し得た前縦隔原発Germ cell tumor with somatic type mahgnancyの1例2007
- Author(s)
  高橋祐介, 池田達彦, 河野光智, 堀之内宏久, 林雄一郎, 小林紘一, 仁木利郎
- Journal Title
  
  肺癌 47
  
  Pages: 793-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] 術前化学療法後に外科的切除し得た前縦隔原発Germ cell tumor with somatic typemalignancy の1 例2007
- Author(s)
  高橋祐介, 池田達彦, 河野光智, 堀之内宏久, 林雄一郎, 小林紘一, 仁木利郎
- Journal Title
  
  肺癌 47巻6号
  
  Pages: 793-794
- NAID
  110006475037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Fluid resuscitation with hemoglobin-vesicle solution does not increase hypoxia orinflammatory responses in moderate hemorrhagic shock2006
- Author(s)
  Goto Y, Terajima K, Tsueshita T, Miyashita M, Horinouchi H , Sakai H, Tsuchida E, Sakamoto A.
- Journal Title
  
  Biomed Res 27(6)
  
  Pages: 283-288
- NAID
  130004470673
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] PEGylated albumin-heme as an oxygen-carrying plasma expander : Exchange transfusion into acute anemia rat model.2006
- Author(s)
  Huang Y, Komatsu T, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E
- Journal Title
  
  Biomaterials 27・25
  
  Pages: 4477-4483
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Early pulmonary resection for Mycobacterium avium complex lung disease treated with macrolides and quinolones2006
- Author(s)
  Watanabe M, Hasegawa N, Ishizaka A, Asakura K, Izumi Y, Eguchi K, Kawamura M, Horinouchi H, Kobayashi K.
- Journal Title
  
  Ann Thorac Surg 81(6)
  
  Pages: 2026-2030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] Prognosis of surgically treated thymic epithelial tumors2006
- Author(s)
  Horinouchi H, Asakura K, Kimura Y, Takeuchi K, Kawamura M, Watanabe M, Eguchi K, Kobayashi K
- Journal Title
  
  Nippon Geka Gakkai Zasshi 107(6)
  
  Pages: 262-267
- NAID
  110004852494
- Data Source
  KAKENHI-PROJECT-18599007
[Journal Article] PEGylated albumin-heme as an oxygen-carrying plasma expander : Exchange transfusion into acute anemia rat model2006
- Author(s)
  Huang Y, Komatsu T, Yamamoto H, Horinouchi H , Kobayashi K, Tsuchida E.
- Journal Title
  
  Biomaterials 27(25)
  
  Pages: 4477-4483
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Hemoglobin-vesicles as atransfusion alternative2006
- Author(s)
  Tsuchida E, Sakai H, Horinouchi H , Kobayashi K.
- Journal Title
  
  Artif Cells Blood Substit Immobil Biotechnol(Review) 34(6)
  
  Pages: 581-588
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] 胸腺上皮性腫瘍の外科治療成績2006
- Author(s)
  堀之内宏久, 朝倉啓介, 木村吉成, 竹内健, 川村雅文, 渡辺真純, 江口圭介, 小林紘一
- Journal Title
  
  日本外科学会雑誌 107・6
  
  Pages: 262-267
- NAID
  110004852494
- Data Source
  KAKENHI-PROJECT-18591560
[Journal Article] Effect of the cellular-type artificial oxygen carrier Hb-vesicle as a resuscitative fluid for pre-hospital treatment
- Author(s)
  Seishi Y, Horinouchi H, Sakai H, Kobayashi K
- Journal Title
  
  Experiments in a rat uncontrolled hemorrhagic shock model Shock
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21591824
[Journal Article] A new method for measuring the oxygen diffusion constant and oxygen consumption rate of arteriolar walls
- Author(s)
  Sasaki N, Horinouchi H、Ushiyama A, Minamitani H
- Journal Title
  
  Keio Journal of Medicine
  
  Volume: (In press)
- NAID
  10030771368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Fluid resuscitation using large volume of hemoglobin vesicle in rat continuous hemorrhage model(2^<nd> report)2011
- Author(s)
  Seishi Y, Horinouchi H, Sakai H, Kobayashi K
- Organizer
  XIII ISBS
- Place of Presentation
  Boston MA USA
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] 術中出血に対するヘモグロビン小胞体投与の効果と安全性 -肺切除+40%交換輸血モデルでの検討-2011
- Author(s)
  河野光智、後藤太一郎、大塚崇、安樂真樹、泉陽太郎、渡辺真純、堀之内宏久、小林紘一
- Organizer
  第64回日本胸部外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-22591575
[Presentation] Influence of hemoglobin vesicle on oxygen diffusion constant of arteriolar wall in microcirculation of mouse dorsal skin window chamber2011
- Author(s)
  堀之内宏久
- Organizer
  第13回血液代替物国際会議
- Place of Presentation
  Boston, MA (U.S.A)
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Influence of Hemoglobin vesicle on oxygen diffusion constant of arteriolar wall in microcirculation of mouse dorsal skin window chamber2011
- Author(s)
  Horinouchi H, Sasaki N, Seishi Y, Kobayashi K, Sakai H
- Organizer
  XIII ISBS
- Place of Presentation
  Boston MA USA
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Spatiotemporal measurement of tumor oxygeneation reveals repeat hypoxic phenomenon in mice2011
- Author(s)
  山田遼、塚田孝祐、堀之内宏久
- Organizer
  33th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Place of Presentation
  Boston, MA (U.S.A)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Hb小胞体の動物投与の成績2010
- Author(s)
  堀之内宏久
- Organizer
  第17回血液代替物学会年次大会
- Place of Presentation
  熊本(熊本市国際交流会館)
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Effect of large volume resuscitation with the cellular type artificial oxygen carrier(Hb-vesicle) in rat model of uncontrolled hemorrhagic shock via caudal artery2009
- Author(s)
  Seishi Y, Horinouchi H, Sakai H, Tsuchida E, Kobayashi K
- Organizer
  XII ISBS
- Place of Presentation
  Parma, Italy
- Year and Date
  2009-08-26
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] Resuscitation with Hemoglobin-Vesicle can improve survival and oxygen metabolism in uncontrolled hemorrhage model in rats2009
- Author(s)
  Horinouchi H, Seishi Y, Kobayashi K, Izumi Y, Kohno M, Sakai H, Tsuchida E
- Organizer
  Hemorrhage from large vessel model XII ISBS
- Place of Presentation
  Parma, Italy
- Year and Date
  2009-08-26
- Data Source
  KAKENHI-PROJECT-21591824
[Presentation] A Study on oxygen diffusion and oxygen consumption in vessel wall of tumor microcirculation2009
- Author(s)
  Sasaki N, Murakami R, Horinouchi H, Minamitani H
- Organizer
  第34回日本微小循環学会年次総会
- Place of Presentation
  北里大学薬学部コンベンションホール
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] ガスキャリアとしての人工酸素運搬体と肺循環2008
- Author(s)
  堀之内宏久
- Organizer
  第15回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] Enhanced radiation response by artificial oxygen carrier2008
- Author(s)
  Hirohisa Horinouchi, Hisashi Yamamoto, Takayo Oba, Mizuha Haraguchi, Koichi Kobayashi, Teruaki Komatsu, Eishun Tsuchida
- Organizer
  ISOTT2008
- Place of Presentation
  Sapporo
- Year and Date
  2008-08-05
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] 輸血代替としての利用法 Beagle 犬を用いた40%脱血ショックにおけるHb 小胞体の蘇生効果および中長期生存後の安全性の検討2008
- Author(s)
  池田達彦, 堀之内宏久, 井澤菜緒子, 河野光智, 泉陽太郎, 渡辺真純, 川村雅文, 宗慶太郎, 酒井宏水, 土田英俊, 小林紘一
- Organizer
  第15回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] 輸血代替としての利用法腎傷害による制御不能出血モデルに対するヘモグロビン小胞体の蘇生効果2008
- Author(s)
  勢司泰久, 堀之内宏久, 相川直樹, 酒井宏水, 土田英俊, 小林紘一
- Organizer
  第15回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] 輸血代替としての利用法マウス肺切除+周術期出血モデルでのヘモグロビン小胞体投与の有効性の検討2008
- Author(s)
  河野光智, 竹田貴, 堤恭介, 池田達彦, 泉陽太郎, 渡辺真純, 堀之内宏久, 小林紘一, 酒井宏水, 土田英俊
- Organizer
  第15回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] マウス出血性ショック時における人工赤血球投与の脳酸素分圧への影響2008
- Author(s)
  冨田裕, 鳥海春樹, TatarishviliJemal, 冨田稔, 畝川美悠紀, 酒井宏水, 土田英俊, 堀之内宏久, 小林紘一, 鈴木則宏
- Organizer
  第20回脳循環代謝学会総会
- Place of Presentation
  東京
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] Molecular artificial oxygen carrier“albumin-heme"can en hance radiation response of solid tumor. Experimental in vivo study.2008
- Author(s)
  Horinouchi H, Yamamoto H, Komatsu T, Yubin Huang, Tsuchida E, Kobayashi K.
- Organizer
  36^<th> Annual Conference of International Sosiety on Oxygen Transport to Tissue
- Place of Presentation
  Sapporo Prince Hotel
- Year and Date
  2008-08-05
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] 輸血代替としての利用法血管損傷による制御不能出血性ショックの蘇生人工酸素運搬体の効果について2008
- Author(s)
  堀之内宏久, 勢司泰久, 河野光智, 泉陽太郎, 酒井宏水, 小林紘一, 土田英俊
- Organizer
  第15回日本血液代替物学会年次大会
- Place of Presentation
  東京
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18591560
[Presentation] 実験的胸膜播種モデルにおける原発巣由来ストローマ細胞の関与についての検討2007
- Author(s)
  河野光智, 羽藤泰, 泉陽太郎, 渡辺真純, 川村雅文, 堀之内宏久, 小林紘一
- Organizer
  第48回日本肺癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-18599007

1. KOBAYASHI Kouichi (80051704)

# of Collaborated Projects: 9 results

# of Collaborated Products: 41 results
2. WATANABE Masazumi (90201227)

# of Collaborated Projects: 8 results

# of Collaborated Products: 10 results
3. IZUMI Yotarou (90245506)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
4. KOHNO Mitsutomo (10276272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. YAMAMOTO Manabu (10317159)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SHIGEMATSU Naoyuki (30178868)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMAUCHI Tokuko (30306732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. IWAMARU Arifumi (00296592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KAWAMURA Masafumi (70169770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. FUJIMOTO Hiroyuki (20338073)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. IKEDA Tatsuo (00383802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. TSUKADA Kosuke (00351883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. NOMORI Hiroaki (90146613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAKAI Hiroshi (70318830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAJIMA Atsushi (50276276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KIMURA Yoshishige (80327535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大塚崇 (40306717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORINOUCHI Hirohisa 堀之内 宏久

Research Projects

Research Products

Co-Researchers

悪性腫瘍の低酸素環境調節因子としての細動脈での酸素拡散・消費に関する検討Principal Investigator

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Application of hemoglobin vesicles for lung transplantation

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Analysis of oxygen transport to malignant tumor and mechanism of enhancing effect of treatment by oxygenation of tumor tissuePrincipal Investigator

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Enhanced radiation response andn inhibition of angiogenesis by artificial oxygen carrierPrincipal Investigator

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Lung cancer cells metastasize together with tumor-derived host cells

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Control of angiogenesis by attenuation of oxygen tension in the metastatic tumor of the lungPrincipal Investigator

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Changes in oxygen metabolism in solid tumors by administration of artificial oxygen carriers

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Analysis of metastasis mechanism in experimental lung metastasis with heparanase transgenic tumor cellsPrincipal Investigator

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Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

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Analysis of microcirculation of experimental metastatic lung tumor using artificial oxygen carrier as a tool for altering the microvascular tonePrincipal Investigator

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Bronchoscopic microsampling method for the diagnosis of small lung cancer

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Tumor oxygenation to in crease sensitivity to anti-cancerous drug by using artificial oxygen carrier

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[Book] MOOK肺癌の臨床疫学・病理・発見・診断・治療2006-2006/高齢者肺癌の外科治療2006

Author(s)

Total Pages

Publisher

HORINOUCHI Hirohisa 堀之内宏久