SAKAGUCHI Kazushige 坂口和成

… Alternative Names

坂口一成サカグチカズシゲ

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Researcher Number	60178548
Affiliation (Current)	2022: 和歌山県立医科大学, 先端医学研究所, 教授
Affiliation (based on the past Project Information) *help	2009 – 2016: Wakayama Medical University, 先端医学研究所, 教授 2009 – 2014: Wakayama Medical University, 付置研究所, 教授 2012: 和歌山県立医科大学, 和歌山県立医科大学, 教授 2008: Wakayama Medical University, 付置研究所・分子医学研究部, 教授 2007: Wakayama Medical University, 付置研究所, 教授 … More 2002 – 2004: Wakayama Medical University Institute of Advanced Medicine Professor, 付置研究所, 教授 2002: 和歌山県立医科大学, 位置研究所, 教授 2001: 和歌山県立医科大学, 付属研究所, 教授 1999 – 2000: 和歌山県立医科大学, 付置研究所, 教授 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Endocrinology / Endocrinology Except Principal Investigator Endocrinology / Radiation science / Thoracic surgery / General medical chemistry
Keywords	Principal Investigator Eph / ephrin / Yeast Two Hybrid / 繊維芽細胞増殖因子受容体 / グリコサミノグリカン / 細胞内情報伝達 / エフリン / パーキンソン病 / 神経幹細胞 / ラット … More / 再生医学 / 再生医療 / マーモセット / ephrin(エフリン) / 体格決定 / 成長ホルモン / インスリン様成長因子 / JAK2 / STAT / シグナル伝達 / GH-IGF1 axis / EphA4 / IGF1 / 体格 / 副甲状腺 / 腫瘍 / 癌遺伝子 / cDNAクローニング / KGF受容体 / 細胞内情報伝達分子 / cDNA クローニング / parathyroid / tumor / oncogene / cDNA cloning / keratinocyte growth factor receptor / signal transduction … More Except Principal Investigator Eph / EphA4 / FGFR / 成長障害 / 成長ホルモン / IGF1 / シグナル伝達 / ゲルスペーサー / 前立腺癌 / 再照射 / ヒアルロン酸 / 危険臓器移動術 / 前立腺癌術後再発 / スペーサー / 危険臓器回避 / トモセラピー / 放射線治療 / ヒアルロン酸ゲル / IMRT / IGRT / 放射線性直腸炎 / Hyaluronate / Spacer / Migration Assay / Prostate cancer / Esophageal Cancer / Breast Cancer / SubQ / Hyaluronann / risk organ / brachytherapy / reirradiation / uterine cancer / prostate cancer / spacer / radiotherapy / GHR / JAK2 / STAT5B / GH-IGF1 / GH-IGF1 軸 / ATAT5B / ephrin / 分子間相互作用 / GH-IGF1軸シグナル伝達系 / 肺癌 / 脳転移 / インテグリン / ラミニン / Lung Cancer / Brain Metastasis / Integrin / Laminin / 神経幹細胞 / Neural stem cell Less

New Insights into the GH-IGF1 axis of Signal Transduction: Elucidation of the Molecular Interactions
- Principal Investigator
  
  Jing Xuefeng
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Wakayama Medical University
Studies on a novel signaling pathway that mediates postnatal body growthPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Kazushige
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Wakayama Medical University
Development of a risk-organ-shifting technique during radiation therapy, with gel spacer
- Principal Investigator
  
  KISHI KAZUSHI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Wakayama Medical University
Genetic and molecular analysis of growth retardation caused by growth hormone insensitivity
- Principal Investigator
  
  JING Xuefeng
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Wakayama Medical University
Development of a new regenerative treatment for Parkinson's disease by way of inducing proliferation, migration, and differentiation of neural stem cells in situPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Kazushige
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Wakayama Medical University
Study of a novel signal transduction pathway mediated by fibroblast growth factor receptor(FGFR)
- Principal Investigator
  
  YOKOTE Hideyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Wakayama Medical University
線維芽細胞増殖因子受容体の糖鎖による修飾とその細胞内情報伝達系への影響Principal Investigator
- Principal Investigator
  
  坂口和成
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Wakayama Medical University
Establishment of brain metastatic model of NS CLC and investigation for the mechanism of brain metastasis of NS CLC
- Principal Investigator
  
  YOSHIMASU Tatsuya
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Wakayama Medical University
Molecular studies on the regulation of parathyroid cell growth and the mechanisms of parathyroid adenoma developmentPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Kazushige
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Wakayama Medical University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

[Journal Article] EphA4-deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF1 signal2016
- Author(s)
  Xuefeng Jing (京　雪楓 Corresponding Author), Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura and Kazushige Sakaguchi
- Journal Title
  
  Cancer Medicine
  
  Volume: 1 Pages: 1-14
- DOI
  10.1002/cam4.470
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461394
[Journal Article] Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2α2015
- Author(s)
  Sawada T, Arai D, Xuefeng Jing (京　雪楓 co-first author), Furushima K, Chen Q, Kawakami K, Yokote H, Miyajima M, Sakaguchi K
- Journal Title
  
  PLoS One
  
  Volume: 1 Pages: 1-15
- DOI
  10.1371/journal.pone.0128826
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461394
[Journal Article] EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.2015
- Author(s)
  Chen Q, Arai D, Kawakami K, Sawada T, Xuefeng Jing (京　雪楓), Miyajima M, Hirai S, Sakaguchi K
- Journal Title
  
  PLoS One
  
  Volume: 1 Pages: 1-24
- DOI
  10.1371/journal.pone.0126942
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461394, KAKENHI-PROJECT-26440008
[Journal Article] Trans-activation between EphA and FGFR Regulates Self-renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2alpha2015
- Author(s)
  Takahiro Sawada, Daiki Arai, Xuefeng Jing, Kenryo Furushima, Qingfa Chen, Kazuki Kawakami, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  PLoS ONE
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591370
[Journal Article] EphA4 regulates the balance between self-renewal and differentiation of radial glial cells and intermediate neuronal precursors in cooperation with FGF signaling2015
- Author(s)
  Qingfa Chen, Daiki Arai, Kazuki Kawakami, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Syu-ichi Hirai, Kazushige Sakaguchi, and Kenryo Furushima
- Journal Title
  
  PLoS ONE
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591370
[Journal Article] Ephrin-A1-Mediated Dopaminergic Neurogenesis and Angiogenesis in a Rat Model of Parkinson's Disease2012
- Author(s)
  Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima, and Kazushige Sakaguchi
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Pages: 1-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Crosstalk of Humoral and Cell-Cell Contact-Mediated Signals in Postnatal Body Growth2012
- Author(s)
  Xuefeng Jing, Masayasu Miyajima, Takahiro Sawada, Qingfa Chen, Keiji Iida, Kenryo, Furushima, Daiki Arai, Kazuo Chihara, and Kazushige Sakaguchi
- Journal Title
  
  Cell Reports
  
  Volume: 2 Pages: 652-665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Crosstalk of Humoral and Cell-Cell Contact-Mediated Signals in Postnatal Body Growth.2012
- Author(s)
  Xuefeng Jing, Masayasu Miyajima, Takahiro Sawada, Qingfa Chen, Keiji Iida, Kenryo Furushima, Daiki Arai, Kazuo Chihara, and Kazushige Sakaguchi
- Journal Title
  
  Cell Reports
  
  Volume: 2 Pages: 652-665
- DOI
  10.1016/j.celrep.2012.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183, KAKENHI-PROJECT-24591370
[Journal Article] Ephrin-A1-Mediated Dopaminergic Neurogenesis and Angiogenesis in a Rat Model of Parkinson’s Disease.2012
- Author(s)
  Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- DOI
  10.1371/journal.pone.0032019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells.2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line, PT-r : Effects of calcium and 1,25(OH)_2D_3.2010
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Machiko Kambayashi, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Yoshio Terada, Kozo Hashimoto, Toshihoro Suda
- Journal Title
  
  Bone
  
  Volume: 47 Pages: 534-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line2010
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Machiko Kambayashi, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Yoshio Terada, Kozo Hashimoto, and Toshihoro Suda
- Journal Title
  
  Effects of calcium and 1,25(OH)2D3
  
  Volume: 47 Pages: 534-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line, PT-r : Effects of calcium and 1,25(OH)_2D_3.2010
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Machiko Kambayashi, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Yoshio Terada, Kozo Hashimoto, Toshihoro Suda
- Journal Title
  
  Bone
  
  Volume: 47 Pages: 534-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Ternary complex formation of EphA4, FGFR and FRS2 plays an important role in the proliferation of embryonic neural stem/progenitor cells2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, and Kazushige Sakaguchi
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Involvement of GCMB in the transcriptional regulation of the human parathyroid hormone gene in a parathyroid-derived cell line, PT-r : Effects of calcium and 1,25(OH)2D3.2010
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Machiko Kambayashi, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Yoshio Terada, Kozo Hashimoto, Toshihoro Suda
- Journal Title
  
  Bone 47
  
  Pages: 534-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  Genes Cells 15:297-311, 2010 15
  
  Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells.2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591183
[Journal Article] Ternary complex formation of EphA4, FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  Genes Cells 15
  
  Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Ternary complex formation of EphA42010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Yueqiang Zhang, Emi Shimada, Hideyuki Yokote, Masayasu Miyajima, Kazushige Sakaguchi
- Journal Title
  
  FGFR and FRS2α plays an important role in the proliferation of embryonic neural stem/progenitor cells Genes Cells 15
  
  Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Predominant role of 250HD in the negative regulation of PTH expression : Clinical relevance for hypovitaminosis D.2008
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, 他7名
- Journal Title
  
  Life Sci 82
  
  Pages: 677-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Dwarfism caused by a defect in a novel growth hormone signaling pathway2008
- Author(s)
  Kazushige Sakaguchi
- Journal Title
  
  Frontier research and groundbreaking studies presented during THE ENDOCRINE SOCIETY
  
  Pages: 85-86
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Predominant role of 25OHD in the negative regulation of PTH expression : clinical relevance for hypovitaminosis2008
- Author(s)
  Masayuki Kawahara, Yasumasa Iwasaki, Kazushige Sakaguchi, Takafumi Taguchi, Mitsuru Nishiyama, Takeshi Nigawara, Makoto Tsugita, Machiko Kambayashi, Toshihoro Suda, Kozo Hashimoto
- Journal Title
  
  D Life Science 82
  
  Pages: 677-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Regulation of Ephexin1, a Guanine Nucleotide Exchange Factor of Rho Family GTPases, by Fibroblast Growth Factor Receptor-mediated Tyrosine Phosphorylation2007
- Author(s)
  Yueqiang Zhang, Takahiro Sawada, Xuefeng Jing, Hideyuki Yokote, Xiaomei Yan, Kazushige Sakaguchi
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 31103-31112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Journal Article] Regulation of Ephexin1, a Guanine Nucleotide Exchange Factor of Rho Family GTPases, by Fibroblast Growth Factor Receptor-mediated Tyrosine Phosphorylation2007
- Author(s)
  Yueqiang Zhang, Takahiro Sawada, Xuefeng Jing, Hideyuki Yokote, Xiaomei Yan, Kazushige Sakaguchi
- Journal Title
  
  J Biol Chem 282
  
  Pages: 31103-31112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300132
[Patent] 中枢神経障害治療剤および中枢神経障害の治療方法2008
- Inventor(s)
  坂口, 他3名
- Industrial Property Rights Holder
  財団法人大阪産業振興機構
- Filing Date
  2008-02-01
- Data Source
  KAKENHI-PROJECT-19300132
[Patent] 中枢神経障害治療剤および中枢神経障害の治療方法2008
- Inventor(s)
  坂口和成, 京雪楓, 澤田貴宏, 三輪英人
- Industrial Property Rights Holder
  坂口和成
- Filing Date
  2008-02-01
- Data Source
  KAKENHI-PROJECT-19300132
[Patent] 中枢神経障害治療剤および中枢神経障害の治療方法2008
- Inventor(s)
  坂口和成, 京雪楓, 澤田貴宏, 三輪英人
- Industrial Property Rights Holder
  坂口和成
- Filing Date
  2008-02-01
- Overseas
- Data Source
  KAKENHI-PROJECT-19300132
[Patent] 中枢神経障害治療剤及び中枢神経障害の治療方法2008
- Inventor(s)
  坂口和成、京雪楓、三輪英人、澤田貴宏
- Industrial Property Rights Holder
  坂口和成
- Filing Date
  2008-02-01
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Host EphA4 regulates Breast cancer progression via crosstalk of humoral and cell-cell contact-mediated signals.2015
- Author(s)
  Xuefeng Jing (京　雪楓), Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura, Kazushige Sakaguchi
- Organizer
  The 38th Annual Meeting of the Molecular Biology Society of Japan with the 88th Annual Meeting of the Biochemistry
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] Eph-FGFR-FRS2alpha複合体シグナルがマウス胎生神経細胞の増殖と分化を調節する2015
- Author(s)
  48.澤田貴宏、新井大貴、京雪楓、古島謙亮、陳清法、河上和紀、横手秀行、宮嶋正康、鎌田一、坂口和成
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] GH/IGF-I axisにおける新規分子機構2014
- Author(s)
  坂口和成
- Organizer
  Pfizer Endocrinology Forum 特別講演（招待）
- Place of Presentation
  虎ノ門ヒルズ
- Year and Date
  2014-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] 体格決定の新規分子機構2013
- Author(s)
  坂口和成、澤田貴宏、京雪楓、新井大貴、古島謙亮、飯田啓二、千原和夫、宮嶋正康
- Organizer
  第８６回日本内分泌学会学術総会
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] 体格決定の新規分子機構2013
- Author(s)
  坂口和成、澤田貴宏、京雪楓、新井大貴、古島謙亮、飯田啓二、千原和夫、宮嶋正康
- Organizer
  第８６回日本内分泌学会学術総会（招待講演）
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] 成長ホルモン（GH）－インスリン様成長因子（IGF1）軸（GH-IGF1 axis）シグナル伝達系の新展開2013
- Author(s)
  坂口和成、澤田貴宏、新井大貴、京雪楓、古島謙亮、河上和紀、宮嶋正康
- Organizer
  第56回日本甲状腺学会学術集会（招待講演）
- Place of Presentation
  和歌山県民文化会館
- Invited
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] Molecular mechanisms of EphA4-mediated signal modulation of the growth hormone (GH)-Insulin-like growth factor 1 (IGF1) axis2013
- Author(s)
  Takahiro Sawada, Daiki Arai, Xuefeng Jing,　Masayasu Miyajima, Qingfa Chen, Kazuki Kawakami, Kenryo Furushima, and Kazushige Sakaguchi
- Organizer
  ENDO2013 (Endocrine Society's 95th Annual Meeting)
- Place of Presentation
  San Francisco Convention Center
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] 体格決定の新規分子機構2013
- Author(s)
  坂口和成、澤田貴宏、京雪楓、新井大貴、古島謙亮、飯田啓二、千原和夫、宮嶋正康
- Organizer
  第８６回日本内分泌学会学術総会（招待講演）
- Place of Presentation
  仙台国際センター
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] 成長ホルモン（GH）－インスリン様成長因子１（IGF1）軸（GH-IGF1 axis）シグナル伝達系の新展開2013
- Author(s)
  坂口和成、澤田貴宏、新井大貴、京雪楓、古島謙亮、河上和紀、宮嶋正康
- Organizer
  第56回日本甲状腺学会学術集会（招待講演）
- Place of Presentation
  和歌山県民文化会館
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] Crosstalk of the cell surface receptors.2013
- Author(s)
  Kazushige Sakaguchi
- Organizer
  Proteoglycan forum
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] Molecular mechanisms of EphA4-mediated signal modulation of the growth hormone (GH)-Insulin-like growth factor 1 (IGF1) axis2013
- Author(s)
  Takahiro Sawada, Daiki Arai, Xuefeng Jing, Masayasu Miyajima, Qingfa Chen, Kazuki Kawakami, Kenryo Furushima, and Kazushige Sakaguchi
- Organizer
  ENDO2013 (Endocrine Society's 95th Annual Meeting)
- Place of Presentation
  San Francisco Convention Center, USA
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] Molecular mechanisms of EphA4-mediated signal modulation of the growth hormone (GH)-Insulin-like growth factor 1 (IGF1) axis2013
- Author(s)
  Takahiro Sawada, Daiki Arai, Xuefeng Jing, Masayasu Miyajima, Qingfa Chen, Kazuki Kawakami, Kenryo Furushima, and Kazushige Sakaguchi
- Organizer
  ENDO2013 (Endocrine Society's 95th Annual Meeting)
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] EphA4 plays an important role in postnatal body growth2012
- Author(s)
  Daiki Arai, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Qingfa Chen, Kenryo Furushima, Keiji Iida, Kazuo Chihara, and Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Eph4 Plays an Important Role in Postnatal Body Growth.2012
- Author(s)
  Daiki Arai, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Qingfa Chen, Kenryo Furushima, Keiji Iida, Kazuo Chihara, Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] 体格決定に関与する新規分子機構の発見2012
- Author(s)
  坂口和成
- Organizer
  大阪臨床整形外科医会
- Place of Presentation
  大阪リッツカールトンホテル
- Invited
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] Functional analysis of EphA4 in corticogenesis using conditional knockout mice2012
- Author(s)
  Qingfa Chen, Kenryo Furushima, Xuefeng Jing, Masayasu Miyajima, Takahiro.Sawada, Daiki Arai, and Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Functional analysis of EphA4 in corticogenesis using conditional knockout mice.2012
- Author(s)
  Qingfa Chen, Kenryo Furushima, Xuefeng Jing, Masayasu Miyajima, Takahiro Sawada, Daiki Arai and Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Eph4 Plays an Important Role in Postnatal Body Growth.2012
- Author(s)
  Daiki Arai, Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Qingfa Chen, Kenryo Furushima, Keiji Iida, Kazuo Chihara, Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] Functional analysis of EphA4 in corticogenesis using conditional knockout mice.2012
- Author(s)
  Qingfa Chen, Kenryo Furushima, Xuefeng Jing, Masayasu Miyajima, Takahiro Sawada, Daiki Arai and Kazushige Sakaguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24591370
[Presentation] Novel signaling pathways of Eph receptors-Contribution to the stem cell biology and the postnatal body growth2011
- Author(s)
  Kazushige Sakaguchi, Takahiro Sawada, Xuefeng Jing, Kenryo Furushima, Qingfa Chen, Daiki Arai, Masayasu Miyajima
- Organizer
  Shandong-Wakayama medical symposium cerebrating the 25th anniversary of friendship
- Place of Presentation
  中国山東省済南市
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Novel signaling pathways of Eph receptors - Contribution to the stem cell biology and the postnatal body growth2011
- Author(s)
  Kazushige Sakaguchi, Takahiro Sawada, Xuefeng Jing, Kenryo Furushima, Qingfa Chen, Daiki Arai, and Masayasu Miyajima
- Organizer
  Shandong-Wakayama medical symposium cerebrating the 25th anniversary of friendship
- Place of Presentation
  中国山東省済南市
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Ephrin-A1-mediated transformation of subventricular neural stemniche leading to dopaminergic neurogenesis in the dopamine-depleted striatum (poster).2010
- Author(s)
  Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima, Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Signaling through the ternary complex of EphA4, FGFR, and FRS2α.2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Emi Shimada, Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA(poster)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Signaling through the ternary complex of EphA4, FGFR, and FRS2α(poster).2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, EmiShimada, Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Ephrin-A1-mediated transformation of subventricular neural stemniche leading to dopaminergic neurogenesis in the dopamine-depleted striatum.2010
- Author(s)
  Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima, Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA(poster)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Signaling through the ternary complex of EphA4, FGFR, and FRS2.2010
- Author(s)
  澤田貴宏, 京雪楓, 宮嶋正康, 島田栄美, 坂口和成
- Organizer
  Eph/ephrins and cancer meeting (poster).
- Place of Presentation
  Washington-Salem, NC
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Functional and structural analysis of Eph-FGFR and Eph-GHR interactions (oral presentation).2010
- Author(s)
  Kazushige Sakaguchi, Takahiro Sawada, Xuefeng Jing, Emiko Shimada, Masayasu Miyajima
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Functional and structural analysis of Eph-FGFR and Eph-GHR interactions.2010
- Author(s)
  坂口和成, 澤田貴宏, 京雪楓, 島田栄美, 宮嶋正康
- Organizer
  Eph/ephrins and cancer meeting (oral presentation)
- Place of Presentation
  Washington-Salem, NC
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Ephrin-A1-mediated transformation of subventricular neural stem niche leading to dopaminergic neurogenesis in the dopamine-depleted striatum (poster)2010
- Author(s)
  Xuefeng Jing, Hideto Miwa, Takahiro Sawada, Ichiro Nakanishi, Tomoyoshi Kondo, Masayasu Miyajima and Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Ephrin-A1-mediated transformation of subventricular neural stem niche leading to dopaminergic neurogenesis in the dopamine-depleted striatum.2010
- Author(s)
  京雪楓, 三輪英人, 澤田貴宏, 中西一郎, 近藤智善, 宮嶋正康, 坂口和成
- Organizer
  Eph/ephrins and cancer meeting (poster).
- Place of Presentation
  Washington-Salem, NC
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] 早期開眼ラット(early open eye lid, eoel)の研究2010
- Author(s)
  宮嶋正康、岡田由香、雑賀司珠也、坂口和成
- Organizer
  眼創傷治癒研究会
- Place of Presentation
  和歌山市
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Signaling through the ternary complex of EphA4, FGFR and FRS2 (poster)2010
- Author(s)
  Takahiro Sawada, Xuefeng Jing, Masayasu Miyajima, Emi Shimada and Kazushige Sakaguchi
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Functional and structural analysis of Eph-FGFR and Eph-GHR interactions.2010
- Author(s)
  Kazushige Sakaguchi, Takahiro Sawada, Xuefeng Jing, Emiko Shimada, Masayasu Miyajima
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA(oral presentation)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Functional and structural analysis of Eph-FGFR and Eph-GHR interactions (oral presentation)2010
- Author(s)
  Kazushige Sakaguchi, Takahiro Sawada,Xuefeng Jing, Emiko Shimada, and Masayasu Miyajima
- Organizer
  Eph/ephrins and cancer meeting
- Place of Presentation
  Washington-Salem, NC, USA
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] 新規成長ホルモン不応性成長障害の発症機序2009
- Author(s)
  宮嶋正康, 京雪楓, 澤田貴宏, 島田栄美, 飯田啓二, 村垣泰光, 千原和夫, 坂口和成
- Organizer
  第27回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-21591183
[Presentation] Ephrin-A1-mediated transformation of the subventricular neural stem cell niche leading to dopaminergic neurogenesis in the dopamine-depleted striatum2009
- Author(s)
  京雪楓, 三輪英人, 澤田貴宏, 横手秀行, 村垣泰光, 中西一郎, 近藤智善, 宮嶋正康, 坂口和成
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Ephrin-A1-mediatedtransformation of the subventricularneural stem cell niche leading todopaminergic neurogenesis in thedopamine-depleted striatum.2009
- Author(s)
  京雪楓, 三輪英人, 澤田貴宏, 横手秀行, 村垣泰光, 中西一郎, 近藤智善, 宮嶋正康, 坂口和成
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] 新規成長ホルモン不応性成長障害の発症機序2009
- Author(s)
  宮嶋正康、京雪楓、澤田貴宏、島田栄美、飯田啓二、村垣泰光、千原和夫、坂口和成
- Organizer
  第27回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-07-21
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Dwarfism caused by a defect in a novel growth hormone signaling pathway.2008
- Author(s)
  Masayasu Miyajima, Xuefeng Jing, Takahiro Sawada, Keiji Iida, Yasuteru Muragaki, Emi Shimada, Kazuo Chihara, Kazushige Sakaguchi
- Organizer
  Endocrine Society's 90^<th> Annual Meeting(USA)
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-06-18
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Eph-FGFR-FRS2αの複合体を介するシグナル伝達2008
- Author(s)
  澤田貴宏, 京雪楓, 横手秀行, 張月強, 島田栄美, 坂口和成
- Organizer
  第81回日本生化学会大会合同大会 (BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Eph-FGFR-FRS2αの複合体を介するシグナル伝達2008
- Author(s)
  澤田貴宏, 京雪楓, 横手秀行, 張月強, 島田栄美, 坂口和成
- Organizer
  第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] Dwarfism caused by a defect in a novel growth hormone signaling pathway.2008
- Author(s)
  Masayasu Miyajima, Xuefeng Jing, Takahiro Sawada, Keiji Iida, Yasuteru Muragaki, Emi Shimada, Kazuo Chihara, Kazushige Sakaguchi
- Organizer
  Endocrine Society's 90^<th> Annual Meeting
- Place of Presentation
  USA
- Year and Date
  2008-06-18
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] パーキンソン病モデルラットにおける多量化ephrin-A1の脳室内注入の効果について2008
- Author(s)
  京雪楓, 三輪英人, 澤田貴宏, 横手秀行, 村垣泰光, 中西一郎, 近藤智善, 宮嶋正康, 坂口和成
- Organizer
  第二回Movement DisorderSociety, Japan (MDSJ)
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] GHシグナル伝達不全に基づく小人症モデルとしてのEphA4ノックアウトマウス2007
- Author(s)
  宮嶋正康、京雪楓、村垣泰光、飯田啓二、千原和夫、澤田貴宏、張月強、坂口和成
- Organizer
  第24回日本疾患モデル学会総会
- Place of Presentation
  茨城県つくば市
- Year and Date
  2007-08-29
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] FGF23 Function of Reducing the Phosphate (Pi) Uptake is Mediated by Receptors Other Than the FGFR-Klotho Complex in OK-E cells2007
- Author(s)
  T.Sawada, X.Jing, Y.Zhang, X. Yan, K.Sakaguchi
- Organizer
  Annual Meeting of the American Society of Bone and Mineral Research
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-19300132
[Presentation] 新規体格形成シグナル伝達系における分子機構の解析
- Author(s)
  新井大貴、澤田貴宏、京　雪楓、古島謙亮、河上和紀、陳清法、坂口和成
- Organizer
  日本内分泌学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461394
[Presentation] EphA4/GH受容体ヘテロ複合体を介するIGF1産生シグナル制御メカニズムの解析（続報）
- Author(s)
  新井大貴、澤田貴宏、京雪楓、古島謙亮、坂口和成
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25461394

1. JING Shuefeng (70316123)

# of Collaborated Projects: 6 results

# of Collaborated Products: 64 results
2. SAWADA Takahiro (00382325)

# of Collaborated Projects: 5 results

# of Collaborated Products: 64 results
3. MIYAJIMA Masayasu (80137257)

# of Collaborated Projects: 4 results

# of Collaborated Products: 58 results
4. YOKOTE Hideyuki (60316122)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NAKAMURA Masayuki (40145917)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MIWA Hideto (50231626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. FURUSHIMA Kenryo (50392105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
8. ARAI Daiki (90725574)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
9. CHIHARA Kazuo (00107955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. IIDA Keiji (80324911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. KISHI KAZUSHI (70254547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SATO Morio (50154109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. CHIBA Akihiro (60597079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIMASU Tatsuya (60316099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUURA Nariaki (70190402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 奥野悦生 (20124886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Frank Stuart J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 平井秀一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAGUCHI Kazushige 坂口 和成

坂口 一成 サカグチ カズシゲ

Research Projects

Research Products

Co-Researchers

New Insights into the GH-IGF1 axis of Signal Transduction: Elucidation of the Molecular Interactions

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Studies on a novel signaling pathway that mediates postnatal body growthPrincipal Investigator

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Development of a risk-organ-shifting technique during radiation therapy, with gel spacer

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Genetic and molecular analysis of growth retardation caused by growth hormone insensitivity

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Development of a new regenerative treatment for Parkinson's disease by way of inducing proliferation, migration, and differentiation of neural stem cells in situPrincipal Investigator

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Study of a novel signal transduction pathway mediated by fibroblast growth factor receptor(FGFR)

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線維芽細胞増殖因子受容体の糖鎖による修飾とその細胞内情報伝達系への影響Principal Investigator

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Establishment of brain metastatic model of NS CLC and investigation for the mechanism of brain metastasis of NS CLC

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Molecular studies on the regulation of parathyroid cell growth and the mechanisms of parathyroid adenoma developmentPrincipal Investigator

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[Journal Article] EphA4-deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF1 signal2016

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[Journal Article] Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2α2015

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[Journal Article] EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.2015

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[Journal Article] Trans-activation between EphA and FGFR Regulates Self-renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2alpha2015

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[Journal Article] EphA4 regulates the balance between self-renewal and differentiation of radial glial cells and intermediate neuronal precursors in cooperation with FGF signaling2015

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SAKAGUCHI Kazushige 坂口和成

坂口一成サカグチカズシゲ