Takeda Shunichi 武田俊一

… Alternative Names

TAKEDA Shunichi 武田俊一

武田俊一

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Researcher Number	60188191
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 名誉教授
Affiliation (based on the past Project Information) *help	2022: 京都大学, 医学研究科, 名誉教授 2016 – 2021: 京都大学, 医学研究科, 教授 2011 – 2015: 京都大学, 医学(系)研究科(研究院), 教授 2012: 京都大学, 大学院・医学研究科, 教授 2005 – 2011: Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 … More 2009 – 2010: Kyoto University, 大学院・医学研究科, 教授 2005 – 2006: 京都大学, 医学研究科・放射線遺伝学, 教授 1996 – 2004: Kyoto University, 大学院・医学研究科, 教授 1996 – 2003: 京都大学, 医学研究科, 教授 1998: 京都大学, 医学部, 教授 1986 – 1987: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Risk sciences of radiation/Chemicals / General medical chemistry / Risk sciences of radiation and chemicals / General medical chemistry / Molecular biology / Medium-sized Section 50:Oncology and related fields / Molecular biology / Structural biochemistry / Cell biology … More Except Principal Investigator … More 環境影響評価(含放射線生物学) / Structural biochemistry / Molecular biology / Basic Section 56030:Urology-related / Legal medicine / Hygiene / Urology Less
Keywords	Principal Investigator DT40 / DNA修復 / 放射線 / Rad51 / 相同DNA組み換え / 相同DNA組換え / チェックポイント / 標的組換え / DNA polymerase / DT40細胞 … More / 癌治療 / 発がん / ターゲットインテグレーション / 相同組み換え / 遺伝子治療 / 変異 / 化審法 / DNAポリメラーゼ / 損傷乗り越え / 癌 / ヌクレオチド除去修復 / ジーンターゲティング / DNA相同組換え / 染色体断裂 / 組み換え修復 / Fbh1 / Ubc13 / Rad18 / Sister chromatid exchange / Translesion DNA synthesis / DNA replication / DNA damage / 姉妹染色分体交換 / 複製 / DNA損傷 / Homologous DNA recombination / DNA repair / 変異原 / 発がん物質 / 遺伝毒物学 / ハイスループットスクリーニング / 有害化学物質 / 標的組み換え / ニワトリBリンパ細胞 / DNA組換え / DNA組み換え / 細胞・組織 / QSAR / トキシコロジー / シスプラチン / ゲノム不安定性 / 老化 / 遺伝学 / 遺伝子ノックアウト / Ku / Topoisomerase IIβ / DNA Topoisomerase IIΒ / エンハンサー / エストロゲン / DNA Topoisomerase IIB / 卵巣がん / 乳がん / HBOC症候群 / BRCA1 / ヒト細胞 / シタラビン（Cytarabine） / 複製起点 / 複製ポリメラーゼε / 複製ポリメラーゼδ / DNA複製 / 抗がん治療薬 / ケモインフォマティクス / TK6細胞 / 人体有害物質 / Gene targeting / DT40 cell / Targeted integration / Homologous Recombination / 遺伝子破壊 / 相同DM組換え / Homologous DNA recombinatior / Rad 51 / ionizing radiation / homologous DNA recombination / chemothrapy of cancer / checkpoint / fumorigenesis / 電離放射線 / プロテオーム解析 / CRISPR/Cas9 / ゲノム編集 / プロテオノミクス / SILAC / 質量分析 / ユビキトーム / ユビキチン / プロテオミクス / データマイニング / 情報学 / はいスループットスクリーニング / 小核試験 / レギュラトリーサイエンス / 小核実験 / ケミカルジェネティックス / CDK / トポイソメラーゼ阻害薬 / 放射線治療 / p53 / メダカ / バイオテクノロジー / ゲノム / 発がん化学物質 / エームテスト / タモキシフェン / 女性ホルモン / 遺伝子 / 胸腺における選択 / アロ抗原 / 組織適合抗原 / T細胞抗原受容体 / MHC拘束性 / キラーT細胞 / Rad54 / Rad52 … More Except Principal Investigator DT40細胞 / DNA修復 / Rad51 / Chromosome / DNA repair / LOH / 染色体 / Gene targeting technique / 転写制御 / クロマチン構造 / DT40株 / ジーンノックアウト法 / 2D-PAGE / Histone / 2次元電気泳動 / RNase protection assay / ヒストン / エンハンサー / メダカ / Rad52 / 修復 / 染色体不安定性 / Rad54 / c-MYC / トランスクリプトーム / LNCap / ホルモン治療抵抗性 / エンハンサーRNA / アンドロゲン / 前立腺癌 / animal model / Medaka genome / minisatellite / 動物モデル / ミニサテライト / Medaka / Atomic force microscopy / Kinetochore / Telomere / Mitosis / Cell cycle / 組み換え / 細胞周期 / 生命継承 / 細胞分裂周期 / 原子間力顕微鏡 / テロメア / 酵母 / 紡錘体 / 原動体 / Environmental Mutagen / DNA Adduct / DNA Polymerase / DNA Damage / Mutation / 環境変異原 / DNA付加体 / DNAポリメラーゼ / DNA損傷 / 突然変異 / ionizing radiation / XRCC3 / 相同DNA組み換え / 電離放射線 / Cell proliferation / Immunoglobulin / DT40 cells / Histone-modifying enzyme / Chromatin / ヒストンデアセチラーゼ / 細胞増殖 / 免疫グロブリン / ヒストン修飾酵素 / クロマチン / Transcription regulation / Chromatin structure / Histone variants / DT40 / 2次元電気泳動法 / ヒストンバリアント / Gene expression / Compensation / Gene targeting / RNase Protection wethob / RNose Protection assay / 遺伝子発現制御 / 自己補償機構 / 遺伝子破壊法 / Loss of Heterozygosity / RFLPS / 連鎖検定 / MEN2型 / 遺伝性甲状腺髄様癌 / インターロイキン5 / インターロイキン2の受容体 / 人工突然変異 / リンフォカイン遺伝子 / 免疫グロブリン遺伝子 / IL-5遺伝子 / IL-4遺伝子 / 染色体マップ / トランスジェーニックマウス / IL-2リセプター / IL-4 / Bリンパ球の分化 / 抗体遺伝子D断片 / NK細胞 / トランスジュニックマウス / IL-2R / IL-2 / IgM^+IgG^+B細胞 / クラススイッチ / 骨髄細胞からのリンパ球への分化 / ヒト抗体V_H鎖遺伝子 / trans splicing / double isotype expression / transgenic mouse / integrase family / cDNAクローニング / DNA結合タンパク質 / 抗体遺伝子再構成 / 環状DNA / SーS組換え / ショウジョウバエ / リコンビナ-ゼ / ストロ-マ細胞 / 骨髄多分化能細胞 / VDJ組換 / Bリンパ球 / DNA修復機能 / ハイスループット / 遺伝子修復経路 / 環境化学物質 / スクリーニング / DNA障害 / 変異原性 / 発がん性 / DNA 修復経路 / バイオアッセイ / 化学物質 / トポイソメラーゼII / TLS / NHEJ / 精巣腫瘍 / エトポシド / 抗癌剤感受性 / 姉妹染色分体交換 / 遺伝子相同組み換え / 相同DNA組み換え機構 / 肺ガン細胞株 / ジーンターゲティング / Rad51関連遺伝子群 / シスプラチン / 染色体異常 / 誘導型ノックアウト / 相同組換え / DNA2重鎖切断 / RAD54 / RAD52 / RAD51 / 相同DNA組換え / プロテアソーム / NK1.1 / 自己免疫疾患 / CD40 / HLA / MHCの進化 / T細胞分化 / T細胞活性化 / 抗原ペプチド / 抗原提示細胞 / T細胞 / Toll-like receptor / プロテマソーム / HLAゲノム解析 / γδT細胞 / 抗原提示 / 樹状細胞 / T細胞抗原受容体 / MHC / 組換えホットスポット / 二重鎖切断 / ウエルナ-症候群 / ブルーム症候群 / 結晶解析 / 不稔 / 接合伝達 / DNA複製フォーク / Mre11 / RuvABC / 減数分裂 / 相同的DNA組換え / MRC11タンパク質 / DMC1タンパク質 / RAD51タンパク質 / SOS反応 / hjc遺伝子 / RuvBタンパク質 / 組換え修復 / DNA組換え Less

Identification of the enhancer sequences that are controlled by androgen receptor
- Principal Investigator
  
  Fujita Jun
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Genome-wide identification of double-strand break sites induced by activated estrogen receptors and Topoisomerase IIBetaPrincipal Investigator
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
ヒトゲノム編集細胞を使った、化学物質の薬理作用・有害性を解析するシステムの構築Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism CharacterizationPrincipal Investigator
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Genome-wide identification of DNA replication origin sequences in human cellsPrincipal Investigator
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Development of a method for increasing gene-targeting efficiency in human cellsPrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Establishment of high-throughput screening of toxic chemical compounds.Principal Investigator
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
遺伝子破壊細胞を使った、化学物質の生物効果をハイスループットに解析するシステムPrincipal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
Comprehensive Analysis of Ubiquitome during DNA damage responsePrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Assessment of combined effect of chemicals with using mutant DT40s and gene knock out Medaka.
- Principal Investigator
  
  KOUNO Kouichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Osaka Medical College
Analysis of DNA damage response using gene-disrupted DT40 clones.Principal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
細胞周期を制御するCDK1のケミカル条件変異ヒト細胞株の樹立と表現型解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Transgenic animal model showing genomic instabilities like human hypervariable minisatellite and its applications in forensic genetics.
- Principal Investigator
  
  TAMAKI Keiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Kyoto University
Reverse Genetic Analysis of DNA Damage responses in the Avian DT40 Cell Line and the Medaka FishPrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
DNA修復遺伝子欠損細胞を用いたDNA損傷抗癌剤感受性の網羅的検討とその臨床応用
- Principal Investigator
  
  三木恒治
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kyoto Prefectural University of Medicine
Analysis of Homologous DNA Recombination using the chicken DT40 B cell linePrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
染色体DNAを保存するシステムに関与する遺伝子群の、ヒトの多型性の機能評価Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
染色体維持機構の変異動物細胞株の表現型を評価するアッセイ系の樹立Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of genetic interactions of DNA repair pathwaysPrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  KYOTO UNIVERSITY
Molecular Analysis of homologous recombination-mediated gene tragetingPrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  KYOTO UNIVERSITY
Maintenance and Inheritance of Diverse Life by Chromosome Dynamics
- Principal Investigator
  
  YANAGIDA Mitsuhiro
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for COE Research
- Research Institution
  Kyoto University
高頻度に標的組み換えを起こすニワトリBリンパ細胞株を使った標的組み換え機構の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
動物体細胞株を使って遺伝学的解析するための基礎技術の開発Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
細胞分裂期の紡錘系に局在する細胞死の誘導および抑制タンパク質の機能解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Development of new assays to evaluate cellular effects of jonizing radiation
- Principal Investigator
  
  TAKATA Minoru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  KAWASAKI MEDICAL SCHOOL
Establishment of Cell Strains Deficient in Genes Related to Mutation Induction, and Analysis of Mutation Mechanisms Using the Cell Strains.
- Principal Investigator
  
  YAGI Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Osaka Rrefecture University
免疫識別と応答の多様性の分子機構
- Principal Investigator
  
  西村泰治, 笹月健彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
  Kyushu University
高頻度に標的組換えを起すニワトリ細胞株を使った染色体構造維持構造の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Joint study on histone modifying enzymes by gene disruption
- Principal Investigator
  
  NAKAYAMA Tatsuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Structural biochemistry
- Research Institution
  Miyazaki Medical College
高頻度にターゲットインテグレーションをおこすニワトリ細胞株の相同組換え機構の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
ヒト癌細胞のシスプラチン感受性決定因子としての相同組み換え関連遺伝子群の役割-ノックアウト細胞株と肺癌細胞株による検討-
- Principal Investigator
  
  高田穣
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
高頻度にターゲットインテグレーションを起すニワトリ細胞株の相同組換え機構の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
遺伝子ターゲッティングの組換え頻度の調節機構の解析-次世代の遺伝子治療への基礎的アプローチ-
- Principal Investigator
  
  園田英一朗
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Joint Study on Nature of Histone Variants by Gene Disruption
- Principal Investigator
  
  NAKAYAMA Tatsuo
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Miyazaki Medical College
Analysis of homologous DNA recombination using the chicken B-lymphocyte linePrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  KYOTO UNIVERSITY
Reverse Genetic Analysis of Homologous DNA Recombination in Higher EukaryotesPrincipal Investigator
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  KYOTO UNIVERSITY
染色体安定性の癌化への関わり(DT40細胞を用いた試み)
- Principal Investigator
  
  IWAI Yuko
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
RAD54変異ニワトリBリンパ細胞株の、DNA複製中に起ったDNA損傷の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ニワトリBリンパ細胞株での、RAD遺伝子群の、DNA組換えと、修復機能の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
MHCクラスIとクラスIIの両方の分子を認識できるT細胞のT細胞抗原受容体の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
遺伝子ターゲッティングの組換え頻度を調節する分子同定の試み:次世代の遺伝子治療への基礎的アプローチ
- Principal Investigator
  
  園田英一朗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
高頻度にターゲットインテグレーションを起こすニワトリB細胞株の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
DNA組換えと組換え修復の普遍的機構
- Principal Investigator
  
  品川日出夫
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
高頻度ターゲットインテグレーションをおこす鶏細胞株での相同組換え機構の解析Principal Investigator
- Principal Investigator
  
  武田俊一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Joint study on nature of histone variants by gene targeting
- Principal Investigator
  
  NAKAYAMA Tatsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Miyazaki Medical College
DNA塩基配列の多型性を利用した遺伝性腫瘍の研究
- Principal Investigator
  
  高井新一郎
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
免疫系における多様性発現機構の分子遺伝学的研究
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  1986 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyoto University

[Book] 医学のあゆみ、DNA損傷修復の概念提起からメカニズム解明へ2015
- Author(s)
  廣田　耕志、武田　俊一
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen2023
- Author(s)
  Najnin Rifat Ara、Al Mahmud Md Rasel、Rahman Md Maminur、Takeda Shunichi、Sasanuma Hiroyuki、Tanaka Hisashi、Murakawa Yasuhiro、Shimizu Naoto、Akter Salma、Takagi Masatoshi、Sunada Takuro、Akamatsu Shusuke、He Gang、Itou Junji、Toi Masakazu、Miyaji Mary、Tsutsui Kimiko M.、Keeney Scott、Yamada Shintaro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 1 Pages: 111909-111909
- DOI
  10.1016/j.celrep.2022.111909
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06122, KAKENHI-PROJECT-21K07148, KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-20KK0186
[Journal Article] Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks2022
- Author(s)
  Akter Salma、Shimba Akihiro、Ikuta Koichi、Mahmud Md. Rasel Al、Yamada Shintaro、Sasanuma Hiroyuki、Tsuda Masataka、Sone Masakatsu、Ago Yukio、Murai Kenichi、Tanaka Hisashi、Takeda Shunichi
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 1 Pages: 53-67
- DOI
  10.1111/gtc.12993
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07148, KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-20K09539
[Journal Article] XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair.2021
- Author(s)
  Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW
- Journal Title
  
  Mol Cell
  
  Volume: in press
- NAID
  120007052730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization.2021
- Author(s)
  Wang J, Oh YT, Li Z, Dou J, Tang S, Wang X, Wang H, Takeda S, Wang Y.
- Journal Title
  
  Cell Rep.
  
  Volume: 34 Issue: 2 Pages: 108625-108625
- DOI
  10.1016/j.celrep.2020.108625
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19K22561
[Journal Article] Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development2021
- Author(s)
  Moribe F, Nishikori M, Takashima T, Taniyama D, Onishi N, Arima H, Sasanuma H, Akagawa R, Elloumi F, Takeda S, Pommier Y, Morii E, Takaori-Kondo A, Murai J.
- Journal Title
  
  PLoS One.
  
  Volume: 16 Issue: 1 Pages: 0237554-0237554
- DOI
  10.1371/journal.pone.0237554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K08324, KAKENHI-PROJECT-19K22561, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-16H06279
[Journal Article] Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.2020
- Author(s)
  Rahman MM, Mohiuddin M, Shamima Keka I, Yamada K, Tsuda M, Sasanuma H, Andreani J, Guerois R, Borde V, Charbonnier JB, Takeda S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 295 Issue: 51 Pages: 17460-17475
- DOI
  10.1074/jbc.ra120.013521
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.2020
- Author(s)
  Mahmud MRA, Ishii K, Lozano CB, Sainz ID, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H.
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 7 Pages: 450-465
- DOI
  10.1111/gtc.12770
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K09686, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-19K22684, KAKENHI-PROJECT-18K09131
[Journal Article] Active learning effectively identifies a minimal set of maximally informative and asymptotically performant cytotoxic structure-activity patterns in NCI-60 cell lines.2020
- Author(s)
  Nakano T, Takeda S, Brown JB.
- Journal Title
  
  RSC Med Chem.
  
  Volume: 11 Issue: 9 Pages: 1075-1087
- DOI
  10.1039/d0md00110d
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks.2020
- Author(s)
  Akagawa R, Trinh TH, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H
- Journal Title
  
  iScience
  
  Volume: 23 Pages: 101027-101027
- NAID
  120006956714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells2020
- Author(s)
  Saha Liton Kumar、Wakasugi Mitsuo、Akter Salma、Prasad Rajendra、Wilson Samuel H.、Shimizu Naoto、Sasanuma Hiroyuki、Huang Shar-yin Naomi、Agama Keli、Pommier Yves、Matsunaga Tsukasa、Hirota Kouji、Iwai Shigenori、Nakazawa Yuka、Ogi Tomoo、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 25 Pages: 14412-14420
- DOI
  10.1073/pnas.1920165117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04265, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19K22561, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-20H00629
[Journal Article] Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells.2020
- Author(s)
  Ibrahim MA, Yasui M, Saha LK, Sasanuma H, Honma M, Takeda S
- Journal Title
  
  Environ Mol Mutagen.
  
  Volume: in press Issue: 6 Pages: 602-610
- DOI
  10.1002/em.22371
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267
[Journal Article] Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells2020
- Author(s)
  Takeishi Ayuna、Kogashi Hiroyuki、Odagiri Mizuki、Sasanuma Hiroyuki、Takeda Shunichi、Yasui Manabu、Honma Masamitsu、Suzuki Tetsuya、Kamiya Hiroyuki、Sugasawa Kaoru、Ura Kiyoe、Sassa Akira
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: 0244790-0244790
- DOI
  10.1371/journal.pone.0244790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.2020
- Author(s)
  Mahmud RA, Ishii K, Lozano BC, Sainz DI, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H
- Journal Title
  
  Genes Cells
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells2020
- Author(s)
  Toshiaki Nakano, Mahmoud I. Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Kouji Hirota, Minoru Takata, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: 0234859-0234859
- DOI
  10.1371/journal.pone.0234859
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18H03374, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] Restoration of ligatable "clean" double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage.2020
- Author(s)
  Sasanuma H, Yamada S, Tsuda M, Takeda S.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 93 Pages: 102913-102913
- DOI
  10.1016/j.dnarep.2020.102913
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K20449
[Journal Article] Systematic approaches to build predictive models for rat oral toxicity.2019
- Author(s)
  Polash AH, Nakano T, Takeda S, *Brown JB
- Journal Title
  
  CICSJ Bulletin
  
  Volume: 37 Pages: 12-21
- NAID
  130007639336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.2019
- Author(s)
  Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0213383-e0213383
- DOI
  10.1371/journal.pone.0213383
- NAID
  120006822506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265
[Journal Article] BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation2019
- Author(s)
  Zong D, Adam S, Wang Y, Sasanuma H, Callen E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A
- Journal Title
  
  Molecular Cell
  
  Volume: 73 Issue: 6 Pages: 1267-1281
- DOI
  10.1016/j.molcel.2018.12.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Applicability Domain of Active Learning in Chemical Probe Identification: Convergence in Learning from Non-Specific Compounds and Decision Rule Clarification.2019
- Author(s)
  Polash AH, Nakano T, Takeda S, Brown JB
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 15 Pages: 2716-2716
- DOI
  10.3390/molecules24152716
- NAID
  120006712779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA2019
- Author(s)
  Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S
- Journal Title
  
  Genes (Basel)
  
  Volume: 10 Issue: 11 Pages: 868-868
- DOI
  10.3390/genes10110868
- NAID
  120006898175
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267
[Journal Article] Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.2018
- Author(s)
  Ooka M, Abe T, Cho K, Koike K, Takeda S, Hirota K.
- Journal Title
  
  PLoS One
  
  Volume: 13(2) Issue: 2 Pages: e0192421-e0192421
- DOI
  10.1371/journal.pone.0192421
- NAID
  120006457113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16K12598
[Journal Article] SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells.2018
- Author(s)
  Nakazato A, Kajita K, Ooka M, Akagawa R, Abe T, Takeda S, Branzei D, Hirota K
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 68 Pages: 50-57
- DOI
  10.1016/j.dnarep.2018.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957
[Journal Article] SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines2018
- Author(s)
  Mohiuddin Mohiuddin、Evans Terry John、Rahman Md Maminur、Keka Islam Shamima、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 50 Pages: 12793-12798
- DOI
  10.1073/pnas.1716349115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes2018
- Author(s)
  Sasanuma Hiroyuki、Tsuda Masataka、Morimoto Suguru、Saha Liton Kumar、Rahman Md Maminur、Kiyooka Yusuke、Fujiike Haruna、Cherniack Andrew D.、Itou Junji、Callen Moreu Elsa、Toi Masakazu、Nakada Shinichiro、Tanaka Hisashi、Tsutsui Ken、Yamada Shintaro、Nussenzweig Andre、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 45
- DOI
  10.1073/pnas.1803177115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-26241014
[Journal Article] Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.2018
- Author(s)
  Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga S.
- Journal Title
  
  Int J Radiat Biol
  
  Volume: 94 Issue: 1 Pages: 88-96
- DOI
  10.1080/09553002.2018.1409443
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-16H02953
[Journal Article] Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.2018
- Author(s)
  Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S
- Journal Title
  
  Environ Mol Mutagen.
  
  Volume: 59 Issue: 6 Pages: 529-538
- DOI
  10.1002/em.22201
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957
[Journal Article] Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families2018
- Author(s)
  Rakers Christin、Najnin Rifat Ara、Polash Ahsan Habib、Takeda Shunichi、Brown J.B.
- Journal Title
  
  ChemMedChem
  
  Volume: 13 Issue: 6 Pages: 511-521
- DOI
  10.1002/cmdc.201700677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K20043, KAKENHI-PROJECT-16H06306
[Journal Article] Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage.2017
- Author(s)
  Liu Y, Wu X, Hu X, Chen Z, Liu H, Takeda S, Qing Y
- Journal Title
  
  Toxicol In Vitro.
  
  Volume: 42 Pages: 130-138
- DOI
  10.1016/j.tiv.2017.04.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells2017
- Author(s)
  Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga S, Takeda S and Tano K
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 9 Pages: e0185141-e0185141
- DOI
  10.1371/journal.pone.0185141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15H04295, KAKENHI-PUBLICLY-16H01642, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts2017
- Author(s)
  Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC and Wilson SH
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Issue: 17 Pages: 10079-10088
- DOI
  10.1093/nar/gkx654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Cytotoxicity of tirapazamine (3-amino-1, 2, 4- benzotriazine-1, 4-dioxide)-induced DNA damage in chicken DT40 cells.2017
- Author(s)
  Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga S, Tano K
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 30 Issue: 2 Pages: 699-704
- DOI
  10.1021/acs.chemrestox.6b00417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15K00537
[Journal Article] ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.2017
- Author(s)
  Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.
- Journal Title
  
  PLos One
  
  Volume: 12 Issue: 11 Pages: e0188320-e0188320
- DOI
  10.1371/journal.pone.0188320
- NAID
  120006800808
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05333, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01737, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16J02252, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01877
[Journal Article] The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).2017
- Author(s)
  Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 20 Pages: 33457-33474
- DOI
  10.18632/oncotarget.16508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440011, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-16K12595, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16H02953
[Journal Article] SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation2017
- Author(s)
  Takehiro Sugimoto, Satoshi Ninagawa, Shimpei Yamano, Tokiro Ishikawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 42 Issue: 2 Pages: 81-94
- DOI
  10.1247/csf.17007
- NAID
  130005708193
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-16K18538
[Journal Article] TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.2017
- Author(s)
  Abo MA, Sasanuma H, Liu X, Rajapakse VN, Huang SN, Kiselev E, Takeda S, Plunkett W, Pommier Y
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 16 Issue: 11 Pages: 2543-2551
- DOI
  10.1158/1535-7163.mct-17-0110
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels.2016
- Author(s)
  Ooka M, Kobayashi K, Abe T, Akiyama K, Hada M, Takeda S, Hirota K
- Journal Title
  
  Chemosphere
  
  Volume: 164 Pages: 106-112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.2016
- Author(s)
  Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 8 Pages: e0161486-e0161486
- DOI
  10.1371/journal.pone.0161486
- NAID
  120005997751
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.2016
- Author(s)
  Takeda S, Hoa NN, Sasanuma H
- Journal Title
  
  J Radiat Res.
  
  Volume: 57 Suppl 1 Issue: S1 Pages: i25-i32
- DOI
  10.1093/jrr/rrw034
- NAID
  120006027206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.2016
- Author(s)
  Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 40 Pages: 64-76
- DOI
  10.1016/j.dnarep.2016.02.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-16H06306
[Journal Article] Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.2016
- Author(s)
  Nishihara K, Huang R, Zhao J, Shahane SA, Witt SK, Smith-Roe SL, Tice RR, Takeda S, Xia M.
- Journal Title
  
  Mutagenesis
  
  Volume: 31 Pages: 69-81
- DOI
  10.1093/mutage/gev055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.2016
- Author(s)
  Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 37 Pages: 59795-59808
- DOI
  10.18632/oncotarget.10928
- NAID
  120005980805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-16H02953
[Journal Article] Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.2016
- Author(s)
  Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K.
- Journal Title
  
  Cell Cycle
  
  Volume: 15(15) Issue: 15 Pages: 1997-2008
- DOI
  10.1080/15384101.2016.1191711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16K12598
[Journal Article] Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations.2016
- Author(s)
  Sharma V, Collins LB, Chen TH, Herr N, Takeda S, Sun W, Swenberg JA, Nakamura J
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 18 Pages: 25377-25390
- DOI
  10.18632/oncotarget.8298
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.2016
- Author(s)
  Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44(15) Pages: 7242-50
- DOI
  10.1093/nar/gkw439
- NAID
  120006338056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-25440011, KAKENHI-PROJECT-16K12598
[Journal Article] Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.2016
- Author(s)
  Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y
- Journal Title
  
  ACS Chem Biol.
  
  Volume: 11 Issue: 7 Pages: 1925-1933
- DOI
  10.1021/acschembio.5b01047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.2016
- Author(s)
  Tian X, Patel K, Ridpath JR, Chen Y, Zhou YH, Neo D, Clement J, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 12 Pages: e0167503-e0167503
- DOI
  10.1371/journal.pone.0167503
- NAID
  120005980904
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01738
[Journal Article] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.2016
- Author(s)
  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsusui K, Takeda S, Sasanuma H
- Journal Title
  
  Mol Cell
  
  Volume: 64 Issue: 3 Pages: 580-592
- DOI
  10.1016/j.molcel.2016.10.011
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes.2016
- Author(s)
  Ohta S, Montano-Gutierrez LF, Alves FL, Ogawa H, Toramoto I, Sato N, Morrison CG, Takeda S, Hudson DF, Rappsilber J, Earnshaw WC
- Journal Title
  
  Mol Cell Proteomics
  
  Volume: 15 Issue: 8 Pages: 2802-2818
- DOI
  10.1074/mcp.m116.057885
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16K18494
[Journal Article] Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway.2015
- Author(s)
  Ninagawa S, Okada T, Sumitomo Y, Horimoto S, Sugimoto T, Ishikawa T, Takeda S, Yamamoto T, Suzuki T, Kamiya Y, Kato K, Mori K.
- Journal Title
  
  The Journal of Cellular Biology
  
  Volume: 211 Issue: 4 Pages: 775-784
- DOI
  10.1083/jcb.201504109
- NAID
  120005672576
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06996, KAKENHI-PROJECT-15K18529, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PUBLICLY-26110725, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26840065, KAKENHI-PROJECT-26291040
[Journal Article] Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end-joining.2015
- Author(s)
  Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K
- Journal Title
  
  Oncogene
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Isotonic regression-based method in quantitative high-throughput screenings for genotoxicity.2015
- Author(s)
  Fujii Y, Narita T, Tice RR, Takeda S, Yamada R
- Journal Title
  
  Dose Response
  
  Volume: 1 Pages: 1-20
- NAID
  120005668062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double‐strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines2015
- Author(s)
  Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 12 Pages: 1059-1076
- DOI
  10.1111/gtc.12310
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26550025, KAKENHI-PROJECT-25281021
[Journal Article] Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation.2015
- Author(s)
  Ooka M, Takazawa H, Takeda S, Hirota K.
- Journal Title
  
  Chemosphere
  
  Volume: 144 Pages: 1901-1907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia.2015
- Author(s)
  Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A.
- Journal Title
  
  Science Advances
  
  Volume: 1 Issue: 3 Pages: 1-9
- DOI
  10.1126/sciadv.1400203
- NAID
  120005601014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021
[Journal Article] Distinct DNA damage spectra induced by ionizing radiation in normoxic and hypoxic cells.2015
- Author(s)
  Shimizu N, Ooka M, Takagi T, Takeda S, Hirota K.
- Journal Title
  
  Radiation Res
  
  Volume: 184(4) Issue: 4 Pages: 442-8
- DOI
  10.1667/rr14117.1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021
[Journal Article] Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity.2015
- Author(s)
  Dillon LW, Kumar P, Shibata Y, Wang YH, Willcox S, Griffith JD, Pommier Y, Takeda S, Dutta A.
- Journal Title
  
  Cell Rep.
  
  Volume: 11 Issue: 11 Pages: 1749-1759
- DOI
  10.1016/j.celrep.2015.05.020
- NAID
  120005829370
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Smarcal1 promotes double-strand-break repair by nonhomologous end-joining2015
- Author(s)
  Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H
- Journal Title
  
  Nucleic Acid Research
  
  Volume: 13 Issue: 13 Pages: 6259-6372
- DOI
  10.1093/nar/gkv621
- NAID
  120005617590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340044, KAKENHI-PROJECT-23221005
[Journal Article] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2015
- Author(s)
  Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
- Journal Title
  
  PLoS Genetics
  
  Volume: 11 Issue: 4 Pages: 1-14
- DOI
  10.1371/journal.pgen.1005065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J01682, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-25460276, KAKENHI-PUBLICLY-26111519, KAKENHI-PROJECT-26670442, KAKENHI-PROJECT-26860666, KAKENHI-PROJECT-15K19486, KAKENHI-PLANNED-23111002, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111004, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-25281019, KAKENHI-PROJECT-15H05713
[Journal Article] The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.2015
- Author(s)
  Hirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips L, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann, A, Sale J, Takeda S
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 43 Issue: 3 Pages: 1671-1683
- DOI
  10.1093/nar/gkv023
- NAID
  120005825923
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-25131714, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25350177, KAKENHI-PROJECT-25440011, KAKENHI-PROJECT-25740016, KAKENHI-PUBLICLY-26114714, KAKENHI-PUBLICLY-26116518
[Journal Article] Abacavir, an anti-HIV-1 drug, targets TDP1 deficient adult T-cell leukemia. Science Advances.2015
- Author(s)
  Kobayashi M, Takeda S, Takaori A, et al.
- Journal Title
  
  Sci Adv.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] BRCA1 and CtIP are both required to recruit dna2 at double-strand breaks in homologous recombination.2015
- Author(s)
  Nguyen NH, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H
- Journal Title
  
  PLoS One
  
  Volume: in press
- NAID
  120005615636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] BRCA1 and CtIP are both required to recruit dna2 at double-strand breaks in homologous recombination.2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0124495-e0124495
- DOI
  10.1371/journal.pone.0124495
- NAID
  120005615636
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-26550025
[Journal Article] Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.2014
- Author(s)
  Murai J, Zhang Y, Morris J, Ji J, Takeda S, Doroshow JH, Pommier YG
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Rationale for PARP inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.2014
- Author(s)
  Murai J, Zhang Y, Morris J, Ji J, Takeda S, Doroshow J, Pommier YG
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 349 Issue: 3 Pages: 408-416
- DOI
  10.1124/jpet.113.210146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.2014
- Author(s)
  Saito Y, Takeda J, Adachi K, Nobe Y, Kobayashi J, Hirota K, Oliveira DV, Taoka M, Isobe T
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex.2014
- Author(s)
  Al Abo M, Dejsuphong D, Hirota K, Yonetani Y, Yamazoe M, Kurumizaka H, Takeda S
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Issue: 3 Pages: 797-807
- DOI
  10.1158/0008-5472.can-13-1443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-25250023, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25650006
[Journal Article] SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.2014
- Author(s)
  Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S
- Journal Title
  
  Genes Cells
  
  Volume: 19 Issue: 10 Pages: 743-754
- DOI
  10.1111/gtc.12173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25650006, KAKENHI-PUBLICLY-26116518
[Journal Article] Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers.2014
- Author(s)
  Kimiyo N.Yamamoto, Hirota Kouji, Shunichi Takeda, and Hiroshi Haeno.
- Journal Title
  
  PLos One
  
  Volume: 9 Issue: 8 Pages: e105724-e105724
- DOI
  10.1371/journal.pone.0105724
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J06811, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021, KAKENHI-PUBLICLY-26116518
[Journal Article] A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes.2014
- Author(s)
  Mohiuddin, Keka IS, Evans TJ, Hirota K, Shimizu H, Kono K, Takeda S, Hirano S
- Journal Title
  
  Arch Toxicol.
  
  Volume: 88 Issue: 1 Pages: 145-160
- DOI
  10.1007/s00204-013-1084-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-25281021
[Journal Article] Berberine induces double-strand DNA breaks in Rev3 deficient cells.2014
- Author(s)
  Hu X, Wu X, Huang Y, Tong Q, Takeda S, Qing Y
- Journal Title
  
  Mol Med Rep.
  
  Volume: 9 Issue: 5 Pages: 1883-1888
- DOI
  10.3892/mmr.2014.1999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.2014
- Author(s)
  Smith S, Fox J, Mejia M, Ruangpradit W, Saberi A, Kim S, Choi Y, Oh S, Wang Y, Choi K, Li L, Hendrickson EA, Takeda S, Muller M, Myung K
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e87203-e87203
- DOI
  10.1371/journal.pone.0087203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.2014
- Author(s)
  Murai J, Marchand C, Shahane SA, Sun H, Huang R, Zhang Y, Chergui A, Ji J, Doroshow JH, Jadhav A, Takeda S, Xia M, Pommier Y
- Journal Title
  
  DNA Repair
  
  Volume: 21 Pages: 177-182
- DOI
  10.1016/j.dnarep.2014.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib.2014
- Author(s)
  Murai J, Huang SY, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow JH, Pommier Y
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 13 Issue: 2 Pages: 433-443
- DOI
  10.1158/1535-7163.mct-13-0803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.2014
- Author(s)
  Ninagawa S, Okada T, Sumitomo Y, Kamiya Y, Kato K, Horimoto S, Ishikawa T, Takeda S, Sakuma T, Yamamoto T, Mori K
- Journal Title
  
  J Cell Biol.
  
  Volume: 206 Issue: 3 Pages: 347-356
- DOI
  10.1083/jcb.201404075
- NAID
  120005468381
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26840065
[Journal Article] Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel.2014
- Author(s)
  Maede Y, Shimizu H, Fukushima T, Kogame T, Nakamura T, Miki T, Takeda S, Pommier Y, Murai J
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 13 Issue: 1 Pages: 214-220
- DOI
  10.1158/1535-7163.mct-13-0551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25740016
[Journal Article] Isotonic regression-based method in quantitative hith-throughput screenings for genotoxicity.2014
- Author(s)
  Fujii Y, Narita T, Tice R, Takeda S, Yamada R
- Journal Title
  
  Dose Response.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein.2013
- Author(s)
  Horimoto S, Ninagawa S, Okada T, Koba H, Sugimoto T, Kamiya Y, Kato K, Takeda S, Mori K
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Issue: 44 Pages: 31517-31527
- DOI
  10.1074/jbc.m113.476010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-24249002, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102008
[Journal Article] The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.2013
- Author(s)
  Saito Y, Takeda J, Okada M, Kobayashi J, Kato A, Hirota K, Taoka M, Matsumoto T, Komatsu K, Isobe T.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 2022-2022
- DOI
  10.1038/srep02022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23241021, KAKENHI-PUBLICLY-24114509, KAKENHI-PUBLICLY-25112513, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25550025, KAKENHI-PROJECT-25550026
[Journal Article] Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks.2013
- Author(s)
  Fujita M, Sasanuma H, Yamamoto KN, Harada H, Kurosawa A, Adachi NHiraoka M, Takeda S, Hirota K.
- Journal Title
  
  PLoS One.
  
  Volume: 8(4)
- NAID
  120005244257
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells.2013
- Author(s)
  Lee S, Liu X, Takeda S, Choi K
- Journal Title
  
  Chemosphere
  
  Volume: 93 Issue: 2 Pages: 434-440
- DOI
  10.1016/j.chemosphere.2013.05.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Interference in DNA replieation can cause mitotic chromosomal breakage unassociated with double-strand breaks2013
- Author(s)
  Fujita Mari, Sasanuma H, Kimiyo N. Yamamoto Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K.
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 4 Pages: 60043-60043
- DOI
  10.1371/journal.pone.0060043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06811, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23659152, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281021
[Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction.2013
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  Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R
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  Neurosci Res.
  
  Volume: 77 Issue: 4 Pages: 228-233
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  10.1016/j.neures.2013.09.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23390232, KAKENHI-PUBLICLY-24111513, KAKENHI-PROJECT-24790879
[Journal Article] hibition of Homologous Recombination by the PCNA-Interacting Protein PARI2012
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  Moldovan GL, Takeda S, et al
- Journal Title
  
  Mol Cell
  
  Volume: 45 Issue: 1 Pages: 75-86
- DOI
  10.1016/j.molcel.2011.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Tyrosyl-DNA phosphodi esterase 1 (TDP1) repairs DNA damages induced by topoisomerases I and II, and base alkylation in vertebrate cells2012
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  Murai J, Takeda S, et al
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 16 Pages: 12848-12857
- DOI
  10.1074/jbc.m111.333963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Potentials and mechanisms of genotoxicity of six Pharmaceuticals frequently detected in freshwater environment2012
- Author(s)
  Liu X, Takeda S, et al
- Journal Title
  
  Toxicol Let
  
  Volume: 211 Issue: 1 Pages: 70-76
- DOI
  10.1016/j.toxlet.2012.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination2011
- Author(s)
  Qing Y, et al
- Journal Title
  
  PLoS Genet
  
  Volume: 7 Issue: 7 Pages: e1002148-e1002148
- DOI
  10.1371/journal.pgen.1002148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22687001, KAKENHI-PROJECT-23221005
[Journal Article] Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics2011
- Author(s)
  Hegarat N, Takeda S, et al
- Journal Title
  
  J Cell Biol
  
  Volume: 195 Issue: 7 Pages: 1103-1113
- DOI
  10.1083/jcb.201105058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway2011
- Author(s)
  Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K
- Journal Title
  
  Proc Natl Acad Sci
  
  Volume: 19 Pages: 6492-6496
- NAID
  120003072120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] Genotoxicity and endocrine disruption potentials of sediment near an oil spill site : 2 years after the Hebei Spirit oil spill2011
- Author(s)
  Ji K, Takeda S, et al
- Journal Title
  
  Environ Sci Technol
  
  Volume: 45 Issue: 17 Pages: 7481-7488
- DOI
  10.1021/es200724x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines2011
- Author(s)
  Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR
- Journal Title
  
  Environ Mol Mutagen
  
  Volume: 57 Issue: 7 Pages: 547-561
- DOI
  10.1002/em.20656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390126, KAKENHI-PROJECT-22687001
[Journal Article] Regulation of the Fanconi anemia pathway by a SUMO-like delivery network2011
- Author(s)
  Yang K, Takeda S, et al
- Journal Title
  
  Genes Dev
  
  Volume: 25 Issue: 17 Pages: 1847-1858
- DOI
  10.1101/gad.17020911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity.2011
- Author(s)
  Evans TJ, Yamamoto KN, Hirota K, Takeda S.
- Journal Title
  
  DNA Repair
  
  Volume: 10 Pages: 1292-8
- NAID
  120002696050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.2011
- Author(s)
  Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 108(16) Pages: 6492-6
- NAID
  120003072120
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines2011
- Author(s)
  Yamamoto NK, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang E, Christopher P.Austin, KL.Witt, Raymond R.T.
- Journal Title
  
  Environmental and Molecular Mutagenesis
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] Genotoxicity and endocrine disruption potentials of sediment near an oil spillt site : 2 years after the Hebei Spir oil spill2011
- Author(s)
  Ji K, et al., Takeda S
- Journal Title
  
  Environ Sci Technol
  
  Volume: 45 Issue: 11 Pages: 7481-7488
- DOI
  10.1021/es104344e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] The histone chaperone FACT maintains replication fork rates2011
- Author(s)
  T.Abe, K.Sugimura, Y.Hosono, Y.Takami, M.Akita, A.Yoshimura, S.Tada, T.Nakayama, H.Murofushi, K.Okumura, S.Takeda, M.Horikoshi, M.Seki & T.Enomoto
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 35 Pages: 30504-30512
- DOI
  10.1074/jbc.m111.264721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370052, KAKENHI-PROJECT-21370075, KAKENHI-PROJECT-21590059, KAKENHI-PUBLICLY-22113502, KAKENHI-PLANNED-22131002, KAKENHI-PROJECT-22380188, KAKENHI-PROJECT-22790281, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23370065
[Journal Article] Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.2011
- Author(s)
  Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR
- Journal Title
  
  Environ Mol Mutagen.
  
  Volume: 52(7) Pages: 547-61
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] SEL1L Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Luminal Proteins but not Transmembrane Proteins in Chicken DT40 Cell Line2011
- Author(s)
  S. Ninagawa, T. Okada, S. Takeda and K. Mori
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 36 Issue: 2 Pages: 187-195
- DOI
  10.1247/csf.11018
- NAID
  130004137570
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058009, KAKENHI-PROJECT-23221005
[Journal Article] Purification of the Human SMN-GEMIN2 Complex and Assessment of Its Stimulation of RAD51-Mediated DNA Recombination Reactions2011
- Author(s)
  Motoki Takaku, Takashi Tsujita, Naoki Horikoshi, Yoshimasa Takizawa, Yong, Qing, Kouji Hirota, Masae Ikura, Tsuyoshi Ikura, Shunichi Takeda, Hitoshi Kurumizaka
- Journal Title
  
  Biochemistry
  
  Volume: 50 Issue: 32 Pages: 6797-6805
- DOI
  10.1021/bi200828g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-22310119, KAKENHI-PROJECT-22687001, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-23710221
[Journal Article] accumulation of RAD51 at double-strand (2010) GEMIN2 promotes breaks in homologous recombination.2010
- Author(s)
  Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S.
- Journal Title
  
  Nucleic Acids Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2010
- Author(s)
  Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y.
- Journal Title
  
  PLoS Genet. 6
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] PTIP promotes DNA double-strand break repair through homologous recombination.2010
- Author(s)
  Wang X, Takenaka K, Takeda S.
- Journal Title
  
  G e n e s C e l l s (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.2010
- Author(s)
  Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J.
- Journal Title
  
  Proc Natl Acad Sci USA. 107
  
  Pages: 21553-7
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res.38:5059-74.2010
- Author(s)
  Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 5059-5074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect.2010
- Author(s)
  Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
- Journal Title
  
  Environ Health Perspect. VOL.117
  
  Pages: 1737-1744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Collaborative action of Brcal and CtIP in elimination of covalent modifi cations from double-strand breaks to facilitate subsequent break repair.2010
- Author(s)
  Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y.
- Journal Title
  
  PLoS Genet. VOL.6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] approach using DNA-repair-deficient (2010) A novel chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants.2010
- Author(s)
  Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
- Journal Title
  
  Environ Health Perspect. 117
  
  Pages: 1737-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S.
- Journal Title
  
  PLoS Genet. 6
- NAID
  120002661519
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Collaborative action of Brcal and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2010
- Author(s)
  Nakamura K, Kogame T, Oshiumi H, Shinohare A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y.
- Journal Title
  
  PLoS Genet. VOL.6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] PTIP promotes DNA double-strand break repair through homologous recombination.2010
- Author(s)
  Wang X, Takenaka K, Takeda S.
- Journal Title
  
  Genes Cells 15
  
  Pages: 243-54
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] DNA polymerases ν and θ are required for efficient Immunoglobulin V gene diversification in chicken.2010
- Author(s)
  Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis T, Takeda S.
- Journal Title
  
  J Cell Biol.
  
  Volume: 189 Pages: 1117-1127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity.2010
- Author(s)
  Evans TJ, Yamamoto KN, Hirota K, Takeda S.
- Journal Title
  
  DNA Repair (Amst).
  
  Volume: 9(12) Pages: 1292-8
- NAID
  120002696050
- Data Source
  KAKENHI-PROJECT-22390126
[Journal Article] A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect2010
- Author(s)
  Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
- Journal Title
  
  Environ Health Perspect. VOL.117
  
  Pages: 1737-1744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage.2010
- Author(s)
  Iijima J, Zeng Z, Takeda S, Taniguchi Y.
- Journal Title
  
  Cancer Res.
  
  Volume: 70 Pages: 8467-8474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.2010
- Author(s)
  Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S.
- Journal Title
  
  PLoS Genet.
  
  Volume: 6
- NAID
  120002661519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage.2010
- Author(s)
  Iijima J, Zeng Z, Takeda S, Taniguchi Y.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 8467-74
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination.2010
- Author(s)
  Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S.
- Journal Title
  
  Nucleic Acids Res. 38
  
  Pages: 5059-74
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] DNA polymerases ν and θ are required for efficient Immunoglobulin V gene diversification in chicken.2010
- Author(s)
  Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis T, Takeda S.
- Journal Title
  
  J Cell Biol. 189
  
  Pages: 1117-27
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Collaborative action of Brca1 Taniguchi and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2010
- Author(s)
  Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Y.
- Journal Title
  
  P L o S G e n e t. 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.2009
- Author(s)
  Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K.
- Journal Title
  
  J Biol Chem. VOL.284
  
  Pages: 26360-26367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.2009
- Author(s)
  Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K.
- Journal Title
  
  J Biol Chem. VOL.284
  
  Pages: 26360-26367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] the non-homologous end-joining repair Okada N. (2009) Genetic evidence that pathway is involved in LINE retrotransposition.2009
- Author(s)
  Suzuki J, Yamaguchi K, Kajikawa M, Ichiyanagi K, Adachi N, Koyama H, Takeda S
- Journal Title
  
  P L o S G e n e t. 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP632009
- Author(s)
  Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Vindigni A, Takeda S, Costanzo V
- Journal Title
  
  Nat Cell Biol 11
  
  Pages: 278-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Bloom DNA helicase facilitates Hirota K. (2009) homologous recombination between diverged homologous sequences.2009
- Author(s)
  Kikuchi K, Abdel-Aziz HI, Yamazoe M, Taniguchi Y, Takeda S
- Journal Title
  
  J B i o l C h e m. 284
  
  Pages: 26360-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.2009
- Author(s)
  Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 26360-7
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63.2009
- Author(s)
  Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Vindigni A, Takeda S, Costanzo V.
- Journal Title
  
  Nat Cell Biol 11
  
  Pages: 278-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.2009
- Author(s)
  Kong X, Ball AR, Jr., Sonoda E, Feng J. Takeda S, Fukagawa T, Yen TJ, Yokomori K
- Journal Title
  
  Mol Cell Biol 20
  
  Pages: 1289-1301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Genetic evidence for single-strand lesions initiating Nbsl-dependent homologous recombination in diversification of Ig V in chicken B lymphocytes.2009
- Author(s)
  Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumlitomo Y, Bree RT, Lowndes NF, Takeda S.
- Journal Title
  
  PLoS Genet 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cohesin associates with spindle poles in a mitosis-specificmanner and functions in spindle assembly in vertebrate cells2009
- Author(s)
  Kong X, Ball AR, Jr., Sonoda E, Fang J, Takeda S, Fukagawa T, Yen TJ, Yokoniori K
- Journal Title
  
  Mol Cell Biol 20
  
  Pages: 1289-1301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants.2009
- Author(s)
  Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S.
- Journal Title
  
  Environ Health Perspect. 117
  
  Pages: 1737-44
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Genetic Evidence That the Non-homologous End-joining Repair Pathway Is Involved in LINE Retrotransposition2009
- Author(s)
  Suzuki J, Yamaguchi K, Kajikawa M, Ichiyanagi K, Adachi N, Koyama H, Takeda S, Okada N
- Journal Title
  
  PLoS Genet
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The vital link between the ubiquitin-proteasome pathway and DNA repair : Impact on cancer therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett. VOL.283
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The Vital Link between the Ubiquitin-Proteasome Pathway and DNA Repair : Impact on Cancer Therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cohesin associates with Fukagawa T, Yen TJ, Yokomori spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells.2009
- Author(s)
  Kong X, Ball AR, Jr., Sonoda E, Feng J, Takeda S, K.
- Journal Title
  
  M o l B i o l C e l l. 20
  
  Pages: 1289-301
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] for single-strand lesions initiating (2009) Genetic evidence Nbs1-dependent homologous recombination in diversification of Ig V in chicken B lymphocytes.2009
- Author(s)
  Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Nakamura K, Sumitomo Y, Bree RT, Lowndes Taniguchi Y, NF, Takeda S.
- Journal Title
  
  P L o S G e n e t. 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The Vital Link between the Ubiquitin-Proteasome Pathway and DNA Repair : Impact on Cancer Therapy2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S
- Journal Title
  
  Cancer Lett (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Geneticevidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of IgV in chicken B lymphocytes.2009
- Author(s)
  Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S.
- Journal Title
  
  PLoS Genet. 5
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] The vital link between the ubiquitin-proteasome pathway and DNA repair : Impact on cancer therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett. VOL.283
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] The vital link between the ubiquitin-proteasome pathway and DNA repair : Impact on cancer therapy.2009
- Author(s)
  Motegi A, Murakawa Y, Takeda S.
- Journal Title
  
  Cancer Lett.(Review) 283
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Genetic Evidence That the Non-homologous End-joining Repair Pathway Is Involved in LINE Retrotransposition.2009
- Author(s)
  Suzuki J, Yamaguchi K, Kajikawa M, Ichiyanagi K, Adachi N, Koyama H, Takeda S, Okada N.
- Journal Title
  
  PLoS Genet
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Genetic evidence for single-strand lesions initiating Nbs1-dependent homologousrecombination in diversification of Ig V in chicken B lymphocytes2009
- Author(s)
  Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S
- Journal Title
  
  PLoS Genet 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] PARP-1 ensures the modulation of replication fork progression by homologous recombination on damaged DNA2008
- Author(s)
  Sugimura K, Takebayashi S, Taguchi H, Takeda S, Okumura K
- Journal Title
  
  J Cell Biol 183
  
  Pages: 1203-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.2008
- Author(s)
  Abe T, Ishiai H, Hosnno Y. Yoshimura A, Tada S, Adachi N. Koyama H, Takata H, Takeda S. Enomoto T, Seki M
- Journal Title
  
  Cell Signal 20
  
  Pages: 1978-1985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation2008
- Author(s)
  Abe T, Ishiai H. Hosono Y, Yoshimura A, Tada S, Adachi N. Koyama H. Takata N, Takeda S. Enomoto T. Seki M
- Journal Title
  
  Cell Signal 20
  
  Pages: 1978-1985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] PARP-1 ensures the modulation of replication fork progression by homologous recombination on damaged DNA.2008
- Author(s)
  Sugimura K, Takebayashi S, Taguchi H, Takeda S, Okuraura K
- Journal Title
  
  J Cell Biol 183
  
  Pages: 1203-1212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cyclin-dependent kinases and cell-cycle Hunt T. transitions: does one fit all?2008
- Author(s)
  Hochegger H, Takeda S
- Journal Title
  
  Nat Rev M o l C e l l B i o l 9(Review)
  
  Pages: 910-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Single stranded DNA binding protein hSSB1 is critical for genomic stability.2008
- Author(s)
  Richard D, Bolderson E, Cubeddu L, Wadsworth RIM, Savage K, Sharma GG, Nicolette M.L, Tsvetanov S, Mcllwraith MJ, Pandita R, Takeda S, Hay TT, Gautier J, West SC, Paull TT, Pandital TK, White MF, Khanna KK
- Journal Title
  
  Nature (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Single stranded DNA binding protein hSSB1 is critical for genomic stability2008
- Author(s)
  Richard K, Boidersan E. Cubeddu L, Wadsonrth RIM, Savage K. Sharma CG, Nicolette ML, Tsvetanov S. MIlwraith MJ. Pandita R, Takeda S. Hay TT. Gautier J. West SC. Paull TT. Pandital TR. White MF. Khanna KK
- Journal Title
  
  Nature 453
  
  Pages: 677-681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.2008
- Author(s)
  Saberi A, Nakahara M, Sale JE, Kikuchi K, Arakawa H, Buerstedde J-M, Takeda S, Sonoda E.
- Journal Title
  
  Mol Cell Biol. 28
  
  Pages: 6113-22
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Ku70 prevents genome instability resulting from heterozygosity of the telomei-ase RNA component in a vertebrate tumour line.2008
- Author(s)
  Faure V, Wenner T, Cooley C, Bourke E, Farr CJ, Takeda S, Morrison CG
- Journal Title
  
  DNA Repair (Amst) 7
  
  Pages: 713-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.2008
- Author(s)
  Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobaysashi M, Yamamoto K, Hcierhorst J, Takeda S, Taniguchi Y
- Journal Title
  
  Biochem Biophys Res Comraun 371
  
  Pages: 225-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] The 9-1-1 DNA clamp is required for immunoglobulin gene conversion2008
- Author(s)
  Saberi A, Nakahara M, Sale JE, Kikuchi K, Arakawa H, Buerstedde J-M, Takeda S, Sonoda E
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 6113-6122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cyclin-dependent kinases and cell-cycle transitions : does onefit all?2008
- Author(s)
  Hochegger H, Takeda S, Hunt T
- Journal Title
  
  Nat Rev Mol Cell Biol (Review) 9
  
  Pages: 910-916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cyclin-dependent kinases and cell-cycle transitions: does one fit all?2008
- Author(s)
  Hochegger H, Takeda S, Hunt T.
- Journal Title
  
  Nat Rev Mol Cell Biol.(Review) 9
  
  Pages: 910-6
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Single stranded DNA binding protein hSSB1 is critical for genomic stability.2008
- Author(s)
  Richard D. Bolderson, E. Cubeddu L, Wadsworth RIN, Savage K, Sharma GG, Nicolette ML, Tsvetanov S. Mellwraith MJ, Pandita R, Takeda S, Hay TT, Gautier J, West SC, Paull TT, Pandital TK, White MF, Khanna KK
- Journal Title
  
  Nature 453
  
  Pages: 677-681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Single stranded DNA binding protein hSSB1 is critical for genomic stability.2008
- Author(s)
  Richard D, Bolderson E, Cubeddu L, Wadsworth RIM, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita R, Takeda S, West SC, Paull TT, Pandita1 TK, White MF, Hay TT, Gautier J, Khanna KK.
- Journal Title
  
  N a t u r e 453
  
  Pages: 677-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion2008
- Author(s)
  Oka H. Sakai if, Sonoda E, Nakamura J, Asagoshi K, Wilson Si, Kobayashi N, Yamamoto K. Heierhorst J, Takeda S. Taniguchi Y
- Journal Title
  
  Biochem Biophys Rei Commun 371
  
  Pages: 225-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.2008
- Author(s)
  Saberi A, Nakahara M, Sale JE, Kikuchi K, Arakawa H, Buerstedde J-H, Takeda S, Sonoda E.
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 6113-6122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.2008
- Author(s)
  Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y.
- Journal Title
  
  Biochem Biophys Res Commun. 371
  
  Pages: 225-9
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cyclin-dependent kinases and cell-cycle transitions : does one fit all?2008
- Author(s)
  Hochegger H, Takeda S, Hunt T.
- Journal Title
  
  Nat Rev Mol Cell Biol (Review) 9
  
  Pages: 910-916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] PARP-1 ensures the modulation of replication Okumura K. fork progression by homologous recombination on damaged DNA.2008
- Author(s)
  Sugimura K, Takebayashi S, Taguchi H, Takeda S
- Journal Title
  
  J C e l l B i o l. 183
  
  Pages: 1203-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.2008
- Author(s)
  Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y.
- Journal Title
  
  B i o c h e m B i o p h y s R e s C o m m u n. 371
  
  Pages: 225-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line2008
- Author(s)
  Faure V, Wenner T, Cooley C, Bourke E, Farr CJ, Takeda S, Morrison CG
- Journal Title
  
  DNA Repair (Mist) 7
  
  Pages: 713-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] RAD18and poly[ADPribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007
- Author(s)
  Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Y, Hua W, Yokomori K, Helleday T, Teraoka Murakawa H, Arakawa H, Buerstedde JM, Takeda S.
- Journal Title
  
  M o l C e l l B i o l. 27
  
  Pages: 2562-2571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.2007
- Author(s)
  Wakasugi M, Matsuura K, Nagasawa A, Fua D, Shimizu H, Yamamoto K, Takeda S, Matsunaga T
- Journal Title
  
  Biochem Biophys Res Commun. 364
  
  Pages: 771-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] DNA damage-dependent acetylation and ubiquitination 1 of H2AX enhances chromatin dynamics.2007
- Author(s)
  Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K and Kamiya K
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 7028-7040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse.2007
- Author(s)
  Kohzaki M, Hatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Trung NV, Szuts D, Sale JE, Shinagawa H, Watanabe M, Takeda S
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 2812-2820
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse.2007
- Author(s)
  Kohzaki M, Hatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Trung NV, Szuts D, Sale JE, Shinagawa H, Watanabe M, Takeda S.
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 2812-2820
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] RAD18 and poly[ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007
- Author(s)
  Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 2562-2571
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] DNA-Dependent Protein Kinase Inhibits AID-Induced Antibody Gene Conversion.2007
- Author(s)
  Cook AJ, Raftery JM, Lau KK, Jessup A, Harris RS, Takeda S, Jolly CJ
- Journal Title
  
  PLoS Biol. 5
  
  Pages: 80-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Functional interactions between BLM and XRCC3 in the cell.2007
- Author(s)
  Otsuki M, Seki M, Inoue E, Yoshimura A, Koto G, Yamanouchi S, Kawabe Y, Tada S, Shinohara A, Komura J, Ono T, Takeda S, Ishii Y, and Enomoto T
- Journal Title
  
  J Cell Biol. 179
  
  Pages: 53-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] An essential role for Cdkl in S phase control, revealed by chemical genetics in vertebrate cells.2007
- Author(s)
  Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T, Takeda S
- Journal Title
  
  J Cell Biol. 178
  
  Pages: 257-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659069
[Journal Article] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologuous recombination.2007
- Author(s)
  Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S
- Journal Title
  
  Mol Cell 25
  
  Pages: 663-675
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] RAD18 and poly[ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007
- Author(s)
  Saberl A, Hochegger H, Szuts D, Lan L, Yasul A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 2562-2571
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] RAD18 and poly[ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.2007
- Author(s)
  Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S.
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 2562-2571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.2007
- Author(s)
  Martin RW, Orelli BJ, Yamazoe M, Minn AJ, Takeda S, Bishop DK
- Journal Title
  
  Cancer Res. 67
  
  Pages: 9658-9665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] An essential role for Cdkl in S phase control, revealed by chemical genetics in vertebrate cells.2007
- Author(s)
  Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T, Takeda S
- Journal Title
  
  J Cell Biol. 178
  
  Pages: 257-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. (Review)2007
- Author(s)
  Takeda S, Nakamura K, Taniguchi Y, Paull TT
- Journal Title
  
  Mol Cell 28
  
  Pages: 351-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse.2007
- Author(s)
  Kohzaki M, Hatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Trung NV, Szuts D, Sale JE, Shinagawa H, Watanabe M, Takeda S.
- Journal Title
  
  M o l C e l l B i o l. 27
  
  Pages: 2812-2820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Functional interactions between BLM and XRCC3 in the cell.2007
- Author(s)
  Otsuki M, Seki M, Inoue E, Yoshimura A, Kato G, Yamanouchi S, Kawabe Y, Tada S, Shinohara A, Komura J, Ono T, Takeda S, Ishii Y, Enomoto T.
- Journal Title
  
  J C e l l B i o l. 179
  
  Pages: 53-63
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.2007
- Author(s)
  Ridpath JR, Nakamura A, Tano K, Luke A.M., Sonoda E, Arakawa E, Buerstedde J-M, Gillespie DAF, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA, Nakamura J.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 11117-11122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Cooperative Roles of Vertebrate Fbhl and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse.2007
- Author(s)
  Kohzaki M, llatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Trung NV, Szuts D, Sale JE, Shinagawa H, Watanabe M, Takeda S
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 2812-2820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Poly (ADP-ribose) Polymerase-1 Accelerates Single-Strand Break Repair in Concert with Poly (ADP-ribose) Glycohydrolase.2007
- Author(s)
  Fisher A, Hochegger H, Takeda S, Caldecott KW
- Journal Title
  
  Mol Cell Biol. 27
  
  Pages: 5597-5605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.2007
- Author(s)
  Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S
- Journal Title
  
  Mol Cell 25
  
  Pages: 663-675
- NAID
  130007000910
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Histone H1 variant, H1R is involved in DNA damage response.2007
- Author(s)
  Hashimoto H, Sonoda E, Takami Y, Kimura H, Nakayama T, Tachibana M, Takeda S, Shinkai Y
- Journal Title
  
  DNA Repair 6
  
  Pages: 1584-1594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Ctp1/CtIP and the MRN Taniguchi Y, complex collaborate in the initial steps of homologous recombination.2007
- Author(s)
  Takeda S, Nakamura K, Paull TT.
- Journal Title
  
  M o l C e l l. 28(Review)
  
  Pages: 351-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.2007
- Author(s)
  Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S.
- Journal Title
  
  M o l C e l l. 25
  
  Pages: 663-675
- NAID
  130007000910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] RAD51 up-regulation bypasses BRCA1 function Bishop DK. and is a common feature of BRCA1-deficient breast tumors.2007
- Author(s)
  Martin RW, Orelli BJ, Yamazoe M, Minn AJ, Takeda S
- Journal Title
  
  C a n c e r R e s. 67
  
  Pages: 9658-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] An essential role for Cdk1 in S phase control, revealed by chemical genetics in vertebrate cells.2007
- Author(s)
  Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T, Takeda S.
- Journal Title
  
  J C e l l B i o l. 178
  
  Pages: 257-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.2007
- Author(s)
  Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S.
- Journal Title
  
  Mol Cell. 25
  
  Pages: 663-675
- NAID
  130007000910
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells.2007
- Author(s)
  Tano K, Nakamura J, Asagoshi K, Arakawa H, Sonoda E, Braithwaite EK, Prasad R, Buerstedde JM, Takeda S, Watanabe M, Wilson SH
- Journal Title
  
  DNA Repair (Amst) 6
  
  Pages: 869-875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.2007
- Author(s)
  Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann AR, Zhao GY, Hochegger H, Boulton SJ and Takeda S
- Journal Title
  
  Cancer Res. 67
  
  Pages: 8536-8543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.2007
- Author(s)
  Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann AR, Zhao GY, Hochegger H, Boulton SJ, Takeda S.
- Journal Title
  
  C a n c e r R e s. 67
  
  Pages: 8536-8543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Connecting the Dots between Septins and the DNA Damage Checkpoint.2007
- Author(s)
  Kinoshita M, Takeda S.
- Journal Title
  
  C e l l 130(Review)
  
  Pages: 777-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.2007
- Author(s)
  Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S
- Journal Title
  
  Mol Cell Biol 25
  
  Pages: 663-675
- NAID
  130007000910
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Interacts with PCNA: Significance of the REV1 BRCT Domain In Vitro and In REV1 Protein Vivo.2006
- Author(s)
  Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC.
- Journal Title
  
  M o l C e l l. 23
  
  Pages: 265-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Ubiquitin-Binding Motifs in REV1 Protein Are Required For Its Role in the Tolerance of DNA Damage.2006
- Author(s)
  Guo C, Tang TS, Blenko M, Parker JL, Blelen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC
- Journal Title
  
  Mol Cell Biol 26
  
  Pages: 8892-8900
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006
- Author(s)
  Taniguchi Y, Takeda S, M, Kamei Y, Todo T, Sasado T, Deguchi T, Furutani-Seiki Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.
- Journal Title
  
  G e n o m e B i o l. 7(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] REV1 Protein Interacts with PCNA : Significance of the REV1 BRCT Domain In Vitro and In Vivo.2006
- Author(s)
  Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC
- Journal Title
  
  Mol Cell 23
  
  Pages: 265-271
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.2006
- Author(s)
  Takenaka K, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S.
- Journal Title
  
  J Biol Chem. 281
  
  Pages: 2000-2004
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] REV1 Protein Interacts with PCNA : Significance of the REV1 BRCT Domain In Vitro and In Vivo.2006
- Author(s)
  Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC.
- Journal Title
  
  Mol Cell. 23
  
  Pages: 265-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Ubiquitin-Binding Motifs in REV1 Protein Are Required For Its Role in the Tolerance of DNA Damage.2006
- Author(s)
  Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Dikic I, Ulrich HD, Friedberg EC.
- Journal Title
  
  M o l C e l l B i o l. 26
  
  Pages: 8892-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Ubiquitin-Binding Motifs in REV1 Protein Are Required For Its Role in the Tolerance of DNA Damage.2006
- Author(s)
  Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC.
- Journal Title
  
  Mol Cell Biol. 26
  
  Pages: 8892-8900
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Vertebrate POLQ and POL cooperate in Base Excision Repair ofβOxidative DNA Damage.2006
- Author(s)
  Yoshimura A, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S.
- Journal Title
  
  M o l C e l l. 24
  
  Pages: 115-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Genetic dissection of vertebrate 53BP1 : a major role in non-homologous end joining of DNA double strand breaks.2006
- Author(s)
  Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y
- Journal Title
  
  DNA Repair (Amst) 5
  
  Pages: 741-749
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] REV1 Protein Interacts with PCNA : Significance of the REV1 BRCT Domain In Vitro and In Vivo.2006
- Author(s)
  Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC
- Journal Title
  
  Mol Cell 23
  
  Pages: 265-271
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Critical roles for Polζ in Cellular Tolerance to Nitric Oxide induced DNA Damage2006
- Author(s)
  Wu X, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S, Yamazoe
- Journal Title
  
  Cancer Research 66
  
  Pages: 748-754
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.2006
- Author(s)
  Wu X, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S., Yamazoe M.
- Journal Title
  
  Cancer Res. 66(2)
  
  Pages: 748-754
- Data Source
  KAKENHI-PROJECT-17659509
[Journal Article] Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.2006
- Author(s)
  Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V, Zhao GY, Saberi A, Masutani M, Adachi N, Koyama H, de Murcia D, Takeda S
- Journal Title
  
  EMBO J. (in press)
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] end-joining and homologous Differential usage of non-homologous recombination in double strand break repair.2006
- Author(s)
  Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S.
- Journal Title
  
  D N A R e p a i r ( A m s t ) 5(Review)
  
  Pages: 1021-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.2006
- Author(s)
  Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S
- Journal Title
  
  DNA Repair (Amst) 5
  
  Pages: 1021-1029
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.2006
- Author(s)
  Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S.
- Journal Title
  
  DNA Repair (Amst). 5
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Critical roles for Polζin Cellular Tolerance to Yamazoe M. Nitric Oxide induced DNA Damage.2006
- Author(s)
  Xiaohua W, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S
- Journal Title
  
  C a n c e r R e s. 66
  
  Pages: 748-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.2006
- Author(s)
  Takenaka T, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 2000-2004
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.2006
- Author(s)
  Takenaka T, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S
- Journal Title
  
  J Biol Chem 281
  
  Pages: 2000-2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Ubiquitin-Binding Motifs in REV1 Protein Are Required For Its Role in the Tolerance of DNA Damage.2006
- Author(s)
  Guo C, Tang TS, Blenko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC
- Journal Title
  
  Mol Cell Biol 26
  
  Pages: 8892-8900
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Critical roles for Polζ in Cellular Tolerance to Nitric Oxide induced DNA Damage.2006
- Author(s)
  Xiaohua W, Takenaka K, Sonoda E, Hochegger H, Kawanishi S, Kawamoto T, Takeda S, Yamazoe M
- Journal Title
  
  Cancer Research 66
  
  Pages: 748-754
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Ubiquitin-Binding Motifs in REV1 Protein Are Required For Its Role in the Tolerance of DNA Damage.2006
- Author(s)
  Guo C, Tang TS, Bienko M, Parker JL, Bielen AB, Sonoda E, Takeda S, Ulrich HD, Dikic I, Friedberg EC
- Journal Title
  
  Mol Cell Biol 26
  
  Pages: 8892-8900
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Vertebrate POLQ and POLβ cooperate in Base Excision Repair of Oxidative DNA Damage. Mol Cell. 24 : 115-252006
- Author(s)
  Yoshimura A, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S
- Journal Title
  
  Mol Cell 24
  
  Pages: 115-125
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Generation of medaka gene knockout models by target-selected mutagenesis.2006
- Author(s)
  Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y., Plasterk RH., Cuppen E
- Journal Title
  
  Genome Biol 7
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks.2006
- Author(s)
  akamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y.
- Journal Title
  
  D N A R e p a i r ( A m s t ) 5
  
  Pages: 741-749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Genetic dissection of vertebrate 53BP1 : a major role in non-homologous end joining of DNA double strand breaks.2006
- Author(s)
  Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y.
- Journal Title
  
  DNA Repair (Amst) 5
  
  Pages: 741-749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Vertebrate POLQ and POL β cooperate in Base Excision Repair of Oxidative DNA Damage. Mol Cell. 24 : 115-252006
- Author(s)
  Yoshimura A, Kohzakl M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasul A, Lan L, Sekl M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S
- Journal Title
  
  Mol Cell 24
  
  Pages: 115-125
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.2006
- Author(s)
  Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S
- Journal Title
  
  DNA Repair (Amst) 5
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Vertebrate POLQ and POL β cooperate in Base Excision Repair of Oxidative DNA Damage.2006
- Author(s)
  Yoshimura A, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S
- Journal Title
  
  Mol Cell 24
  
  Pages: 115-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.2006
- Author(s)
  Takenaka K, Ogi T, Okada T, Sonoda E, Guo C, Friedberg EC, Takeda S
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 2000-2004
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Vertebrate POLQ and POLβ cooperate in Base Excision Repair of Oxidative DNA Damage.2006
- Author(s)
  Yoshimura A, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S.
- Journal Title
  
  Mol Cell. 24
  
  Pages: 115-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Genetic dissection of vertebrate 53BP1 : a major role in non-homologous end joining of DNA double strand breaks.2006
- Author(s)
  Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y
- Journal Title
  
  DNA Repair (Amst) 5
  
  Pages: 741-749
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Fanconi anemia pathway regulate redistribution of BLM in response to cross-link DNA damage2005
- Author(s)
  Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y.M., Arakawa, H., Buerstedde, J.-M., Enomoto, T., Takeda, S., Thompson, L.H., Takata, M.
- Journal Title
  
  EMBO J. 24
  
  Pages: 418-427
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Multiple roles of vertebrate REV genes in DNA repair and recombination2005
- Author(s)
  Okada T, Sonoda E, Yoshimura M, Kawano Y, Saya H, Kozaki M, Takeda S.
- Journal Title
  
  Mol Cell Biol. 25
  
  Pages: 6103-6111
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT402005
- Author(s)
  Yamazoe, M., Sonoda, E., Hochegger, H., Takeda, S.
- Journal Title
  
  DNA Repair (Review) 3
  
  Pages: 1175-1186
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage.2005
- Author(s)
  Yonetani Y, Hochegger H, Sonoda E, Shinya S, Yoshikawa H, Takeda S, Yamazoe M
- Journal Title
  
  Nucleic Acids Res. 33
  
  Pages: 4544-4552
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Regulation of Nuclear Proteasome by Rhp6/Ubc2 through Ubiquitination and Destruction of the Sensor and Anchor Cut8.2005
- Author(s)
  Takeda, K., et al.
- Journal Title
  
  Cell 122
  
  Pages: 393-405
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Similar effects of Brca2 truncation and Rad51 paralog deficiency or immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.2005
- Author(s)
  Hatanaka, A., Yamazoe.M., Sale, J.E., Takata, M., Yamamoto, K., Kitao, H., Sonoda, E., Kikuchi, K., Yonetani, Y., Takeda.S.
- Journal Title
  
  Mol Cell Biol, 25
  
  Pages: 1124-1134
- Data Source
  KAKENHI-PROJECT-17659509
[Journal Article] Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.2005
- Author(s)
  Hatanaka A, Yamazoe M, Sale J E, Takata M, Yamamoto K., Kitao H, Sonoda E, Kikuchi K, Yonetani Y, Takeda S
- Journal Title
  
  Molecular Cell Biology 25
  
  Pages: 1124-1134
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Rad51 paralog deficiency on Similar effects of Brca2 truncation and immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.2005
- Author(s)
  Hatanaka A, Yamazoe M, Sale J.E., Takata M, Yamamoto K, Kitao H, Sonoda E, Kikuchi K, Yonetani Y, Takeda S.
- Journal Title
  
  M o l C e l l B i o l. 25
  
  Pages: 1124-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Multiple roles of vertebrate REV genes in DNA repair and recombination,2005
- Author(s)
  Okada T, Sonoda E, Yoshimura M, Kawano Y, Saya H, Kozaki M, Takeda S
- Journal Title
  
  Molecular Cell Biology 25
  
  Pages: 6103-6111
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Multiple roles of vertebrate REV genes in DNA repair and recombination2005
- Author(s)
  Okada T, Sonoda E, Yoshimura M, Kawano Y, Saya H, Kozaki M, Takeda S
- Journal Title
  
  Mol Cell Biol 25
  
  Pages: 6103-6111
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390076
[Journal Article] Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.2005
- Author(s)
  Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli BJ, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA, Hashimoto N, Takeda S, Sonoda E.
- Journal Title
  
  C a n c e r R e s. 65
  
  Pages: 11704-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends.2005
- Author(s)
  Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N, Matsuzaki Y, Koyama H, van Gent DC, Jasin M, Takeda S.
- Journal Title
  
  Mol Cell Biol. 25(16)
  
  Pages: 6948-6955
- Data Source
  KAKENHI-PROJECT-17659509
[Journal Article] Rapid generation of specific antibodies by enhanced homologous recombination2005
- Author(s)
  Seo, H., Masuoka, M., Murofushi, H., Takeda, S., Shibata, T., Ohta, K.
- Journal Title
  
  Nature Biotech (印刷中)
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.2005
- Author(s)
  Hatanaka, A., Yamazoe, M., Sale, J.E., Takata, M., Yamamoto, K., Kitao, H., Sonoda, E., Kikuchi, K., Yonetani, Y., Takeda, S.
- Journal Title
  
  Mol Cell Biol, 25
  
  Pages: 1124-1134
- Data Source
  KAKENHI-PROJECT-17659509
[Journal Article] Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.2005
- Author(s)
  Takeda, K., et al.
- Journal Title
  
  Cell 122
  
  Pages: 393-405
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Regulation of Nuclear Proteasome by Rhp6/Ubc2 through Ubiquitination and Destruction of the Sensor and Anchor Cut82005
- Author(s)
  Takeda, K., Yanagida, M.
- Journal Title
  
  Cell 122
  
  Pages: 393-405
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.2005
- Author(s)
  Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli B, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA. Hashimoto N, Takeda S, Sonoda E
- Journal Title
  
  Cancer Research 65
  
  Pages: 11704-11711
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] in Homologous DNA Recombination Dual Roles for DNA Polymerase h and Translesion DNA Synthesis.2005
- Author(s)
  Kawamoto T, Araki K, Sonoda E, Yamashita, Y.M., Harada, K.K., Kikuchi1, K., Masutani, C., Hanaoka, F., Nozaki, K., Hashimoto, N., Takeda, S.
- Journal Title
  
  M o l C e l l. 20
  
  Pages: 793-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] Dual Roles for DNA Polymerase h in Homologous DNA Recombination and Translesion DNA Synthesis.2005
- Author(s)
  Kawamoto T, Araki K, Sonoda E, Yamashita YM, Harada KK, Kikuchi K, Masutani C, Hanaoka F, Nozaki K, Hashimoto N, Takeda S
- Journal Title
  
  Mol.Cell 20
  
  Pages: 793-799
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Multiple roles of vertebrate REV genes in DNA repair and recombination2005
- Author(s)
  Okada T, Sonoda E, Yoshimura M, Kawano Y, Saya H, Kozaki M, Takeda S
- Journal Title
  
  Mol. Cell Biol. 25
  
  Pages: 6103-6111
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination2005
- Author(s)
  Hatanaka, A., Yamazoe, M., Sale J.E., Takata, M., Yamamoto, K., Kitao, H., Sonoda, E., Kikuchi, K., Yonetani, Y., Takeda, S.
- Journal Title
  
  Mol.Cell.Biol. 25
  
  Pages: 1124-1134
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Rapid generation of specific antibodies by enhanced homologous recombination2005
- Author(s)
  Seo H, Masuoka M, Murofushi H, Takeda S, Shibata T, Ohta K
- Journal Title
  
  Nature Biotech 23
  
  Pages: 731-735
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.2005
- Author(s)
  Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli B, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA, Hashimoto N, Takeda S, Sonoda E
- Journal Title
  
  Cancer Research 65
  
  Pages: 11704-11711
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] DNA crosslink repair protein SNM1A interacts with PIAS1 in nuclear focus formation2005
- Author(s)
  Ishiai, M., Kimura, M., Namikoshi, K., Yamazoe, M., Yamamoto, K., Arakawa, H., Agematsu, K., Matsushita, N., Takeda, S., Buerstedde, J.-M., Takata, M.
- Journal Title
  
  Mol.Cell.Biol. 25
  
  Pages: 34-43
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends.2005
- Author(s)
  Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N, Matsuzaki Y, Koyama H, van Gent DC, Jasin M, Takeda S
- Journal Title
  
  Mol. Cell Biol. 25
  
  Pages: 6948-6955
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair deficient cells2004
- Author(s)
  Mizutani, A., Okada, T., Shibutani, S., Sonoda, E., Hochegger, H., Nishigori, C., Miyachi, Y., Takeda, S., Yamazoe, M.
- Journal Title
  
  Cancer Research 64
  
  Pages: 3144-3147
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks2004
- Author(s)
  Sasaki, M.S., Takata, M., Sonoda, E., Tachibana, A., Takeda, S.
- Journal Title
  
  Cytogenet Genome Res. 104
  
  Pages: 28-34
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] Centrosome amplification induced by DNA damage occurs during prolonged G2 phase and involves ATM2004
- Author(s)
  Dudson, H., Bourke, E., Jeffers, LJ., Vagnarelli, P., Sonoda, E., Takeda, S., Eamshaw, W.C., Merder, A., Morrison, C.
- Journal Title
  
  EMBO J. 23
  
  Pages: 3864-3873
- Data Source
  KAKENHI-PROJECT-13CE2006
[Journal Article] RAD18 and poly[ADP ribose]polymerase independently suppress the access of nonhomologous end joining to double strand breaks and facilitate homologous recombination mediated repair.
- Author(s)
  Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Hua W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S
- Journal Title
  
  Mol Cell (in press)
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] PTIP promotes DNA double-strand break repair through homologous recombination.
- Author(s)
  Wang X, Takenaka K, Takeda S
- Journal Title
  
  Genes Cells (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
- Author(s)
  Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
- Journal Title
  
  Proc Natl Acad Sci USA. in press
- NAID
  120003072120
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] PTIP promotes DNA double-strand break repair through homologous recombination.
- Author(s)
  Wang X, Takenaka K, Takeda S
- Journal Title
  
  Genes Cells (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.
- Author(s)
  Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Journal Article] Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance bf Crossovers during Recombination Initiated by Replication Fork Collapse.
- Author(s)
  Kohzaki M, Hatanaka A, Sonoda E, Yamazoe M, Kikuchi K, Trung NV, Szuts D, Sale JE, Shinagawa H, Watanabe M, Takeda S
- Journal Title
  
  Mol Cell Biol (in Dress)
- Data Source
  KAKENHI-PROJECT-17013039
[Journal Article] The involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
- Author(s)
  Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: (in press)
- NAID
  120003072120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Rahman MM, Sasanuma H, Tsuda M, Morimoto S, Yamada S, Nussenzweig A, Tanaka H, Takeda S
- Organizer
  FASEB Science Research Conference “The Genetic Recombination and Genome Rearrangements Conference”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22561
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Takeda S
- Organizer
  2019 International Conference: Korean Society for Molecular and Cellular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Takeda S
- Organizer
  The 10th International Symposium on DNA Damage Response & Human Disease, isDDRHD-2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22561
[Presentation] Role of proofreading exonuclease activity of replicative polymerase ε in replication fork slowing at DNA damage2019
- Author(s)
  Tsuda M, Abe T, Tsurimoto T, Shibata T, Takeda S, Hirota K
- Organizer
  分子生物学会
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Rahman MM, Sasanuma H, Tsuda M, Morimoto S, Yamada S, Nussenzweig A, Tanaka H, Takeda S
- Organizer
  FASEB Science Research Conference “The Genetic Recombination and Genome Rearrangements Conference”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2019
- Author(s)
  Takeda S
- Organizer
  16th Annual Dan L Duncan Comprehensive Cancer Center Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 複製ポリメラーゼεの校正活性はDNA損傷における安全なフォーク停止に寄与する2019
- Author(s)
  津田雅貴、阿部拓也、釣本俊樹、柴田武彦、武田俊一、廣田耕志
- Organizer
  第37 回染色体ワークショップ/第18 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mechanistic insight of unique mutations caused by a ribonucleotide embedded into DNA.2019
- Author(s)
  Ayuna TAKEISHI, Manabu YASUI, Hiroyuki SASANUMA, Shunichi TAKEDA, Kaoru SUGASAWA, Masamitsu HONMA, Kiyoe URA, Akira SASSA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and The 48th Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Takeda S
- Organizer
  The 10th International Symposium on DNA Damage Response & Human Disease, isDDRHD-2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Takeda S
- Organizer
  2019 International Conference: Korean Society for Molecular and Cellular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22561
[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells.2019
- Author(s)
  Akira SASSA, Haruto TADA, Ayuna TAKEISHI, Kaho HARADA, Kazuma NAKATANI, Masataka TSUDA, Hiroyuki SASANUMA, Shunichi TAKEDA, Kaoru SUGASAWA, Manabu YASUI, Masamitsu HONMA, Kiyoe URA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and The 48th Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 複製ポリメラーゼεの校正活性はカンプトテシンによるDNA損傷における安全な複製停止に寄与する2019
- Author(s)
  阿部拓也, 津田雅貴, 釣本俊樹, 柴田武彦, 武田俊一, 廣田耕志
- Organizer
  染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] DNA repair proteins involved in the repair of pathological Top2 cleavage complex2018
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference, DNA Topoisomerases in Biology and Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] K63-ubiquitination signaling promotes end-processing of double-strand breaks for subsequent nonhomologous joining2018
- Author(s)
  Takeda S, Sasanuma H, Akagawa R
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] ２本のDNAの絡みを解消する酵素、トポイソメラーゼ２は、温度変化により触媒反応に失敗する頻度が増えDNA２重鎖切断を作る2018
- Author(s)
  武田俊一、笹沼博之、Akter S
- Organizer
  日本ハイパーサーミア学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase Ⅱ-DNA complexes2018
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference, Genomic Instability
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes2018
- Author(s)
  Takeda S
- Organizer
  Life Science Workshop Series 2018, DNA Repair and Radiobiology: Opportunities for Cancer Treatment
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] TK6及びそのDNA修復遺伝子破壊変異体を用いた高感度遺伝毒性試験法の開発2017
- Author(s)
  福田隆之、中村真生、佐藤亮佑、藤原聖、佐々彰、鵜飼明子、武田俊一、安井学、本間正充
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] SUMO化蛋白質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)活性維持と染色体ロスの防止2017
- Author(s)
  廣田耕志、高木季代、津田雅貴、村井純子、Keka Islam, 成田岳雄、藤田真梨、笹沼博之、小林純也、武田俊一
- Organizer
  SUMO研究会
- Place of Presentation
  関西学院大学（大阪府・大阪市）
- Year and Date
  2017-01-22
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and Mre11 maintain genome integrity by eliminating abortive Topoisomerase complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  8th international symposium on DNA Damage Response & Human Disease (isDDRHD-2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 is essential for the removal of lethal Topoisomerase2 covalent cleavage complexes2017
- Author(s)
  Takeda S
- Organizer
  12th Asia-Pacific Conference on Human Genetics (APCHG2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  ATW2017 Ataxia-Telangiectasia Workshop
- Place of Presentation
  ミラノ（イタリア）
- Year and Date
  2017-03-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  Keystone Symposia, DNA Replication and Recombination
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] DNA複製と転写に必須な酵素、トポイソメラーゼ2は病的な２重鎖DNA切断を高頻度に自然発生する2017
- Author(s)
  武田俊一
- Organizer
  第46回放射線による制癌シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 is essential for the removal of lethal topoisomerase 2 cleavage2017
- Author(s)
  Takeda S
- Organizer
  6th US-Japan DNA Repair Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translation synthesis by the replicative DNA polymerase delta2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  DNA Polymerases Meeting
- Place of Presentation
  ビアリッツ（フランス）
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] PAR結合蛋白質ALC1/CHDL1とXRCC1による単鎖切断修復2016
- Author(s)
  廣田　耕志、安井　明、荻　朋男、原田　浩、中村　純、Yves Pommier、武田　俊一
- Organizer
  染色体ワークショップ
- Place of Presentation
  宮城
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Essential role of the Mre11-Rad50-Nbs1 complex in preventing the endogenous accumulation of lethal Topoisomerase2-DNA-cleavage complex2016
- Author(s)
  Takeda S
- Organizer
  The 6th International Conference on Biomedical and Environmental Sciences & Technology, The 7th International Symposium on DNA Damage Response & Human Disease
- Place of Presentation
  成都（中国）
- Year and Date
  2016-10-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2016
- Author(s)
  Takeda S
- Organizer
  Genomic Instability, Gordon Research Conference
- Place of Presentation
  香港（中国）
- Year and Date
  2016-07-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] SUMO E3 ligases PIAS1 and PIAS4 facilitate template switching by enhancing SUMOylation of PCNA2016
- Author(s)
  Mohiuddin, Evans TJ, Takeda S
- Organizer
  Abcam Mechanisms of Recombination 2016
- Place of Presentation
  Alicante, Spain
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12595
[Presentation] The proofreading exonuclease activity of replicative polymerase ε　contributes to cellular tolerance of cytarabine(Ara-C)2016
- Author(s)
  Tsuda M, Takeda S, Hirota K
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  ホテル一畑（島根県・松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translation synthesis by the replicative DNA polymerase delta2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  DNA Polymerases Meeting
- Place of Presentation
  Biarritz, France
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12595
[Presentation] Evidence for translesion synthesis by DNA polymerase in vivo2016
- Author(s)
  Takeda S, Tsuda M, Hirota K, Sale J
- Organizer
  abcam, Maintenance of Genome Stability 2016
- Place of Presentation
  Panama City, Panama
- Year and Date
  2016-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] The Proofreading Exonuclease Activity of Replicative Polymerasee significantly Contributes to Elimination of Cytarabine (Ara-C)2016
- Author(s)
  Tsuda M, Takeda S, Hirota K
- Organizer
  DNA Polymerases Meeting
- Place of Presentation
  ビアリッツ（フランス）
- Year and Date
  2016-10-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translesion synthesis by the replicative DNA polymeraseδ2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  ホテル一畑（島根県・松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] In vivo evidence for translesion synthesis by the replicative DNA polymeraseδ2016
- Author(s)
  Hirota K, Tsuda M, Sale J, Takeda S
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  島根県松江市
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12595
[Presentation] Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels2016
- Author(s)
  Ooka M, Kobayashi K, Abe T, Akiyama K, Hada M, Takeda S, Hirota K
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  ホテル一畑（島根県・松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] SUMO化蛋白質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)活性維持と染色体ロスの防止2016
- Author(s)
  廣田　耕志、高木　季代、津田　雅貴、村井　純子、Keka Islam、成田　岳雄、藤田　真梨、笹沼　博之、小林　純也、武田　俊一
- Organizer
  SUMO研究会
- Place of Presentation
  大阪
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 酸素の有無による電離放射線照射時のDNA損傷の種類の解析2015
- Author(s)
  大岡　正人、清水　直登、高木　季代、武田　俊一、廣田　耕志
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Tsuda M, Hirota K, Hirakawa M, Yang SH, Paull TT, Komatsu K, Takeda S, Sasanuma H
- Organizer
  FASEB Science Research Conferences, Genetic Recombination and Genome Rearrangements
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 抗がん剤の作用機序を遺伝学的手法を使って調べる2015
- Author(s)
  武田　俊一
- Organizer
  天理よろづ相談所学術講演会
- Place of Presentation
  奈良
- Year and Date
  2015-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] The Role of Mre11 Nuclease Myth and Facts2015
- Author(s)
  Takeda S
- Organizer
  16th Ataxia-Telangiectasia Workshop (ATW2015)
- Place of Presentation
  Beijing, China
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Capability of proofreading-exonucreas-deficient replicative DNA polymerase d to perform translesion DNA synthesis2015
- Author(s)
  Hirota K, Tsuda M, Mohiudin, Tsurimoto T, Livneh Z, Iwai S, Sale J, Takeda S
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] DNA修復経路欠損細胞を用いたタバコに含まれる化学物質の遺伝毒性評価2015
- Author(s)
  大岡　正人、高沢　浩則、武田　俊一、廣田　耕志
- Organizer
  バイオコンファレンス2015
- Place of Presentation
  東京
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Genetic Analysis of Proteins Involved in The Initial Step of Double-strand Break Repair2015
- Author(s)
  Takeda S
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  京都
- Year and Date
  2015-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] The Role of Mre11 in double-strand break repair Myth and Facts2015
- Author(s)
  Takeda S
- Organizer
  The 2nd IFOM - KU Joint SymposiumPerspectives in cancer biology: Genomic variations and host-tumor interactions
- Place of Presentation
  京都
- Year and Date
  2015-10-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Differential roles of Mre11 nuclease in DNA damage responses in the budding yeast and mammalian cells2015
- Author(s)
  Takeda S
- Organizer
  CGI International Symposium
- Place of Presentation
  Ulsan, Korea
- Year and Date
  2015-05-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Differential roles of Mre11 nuclease in DNA damage responses in the budding yeast and mammalian cells2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Paull TT, Komatsu K, Takeda S, Sasanuma H
- Organizer
  16th Ataxia-Telangiectasia Workshop (ATW2015)
- Place of Presentation
  Beijing, China
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3' single-stranded ends at double-strand breaks in homologous recombination.2014
- Author(s)
  Nguyen NH, Kobayashi J, Omura M, Tsuda M, Hirota K, Komatsu K, Takeda S, Sasanuma H
- Organizer
  Fusion Conferences, Functional Polymeric Materials
- Place of Presentation
  Cancun, Mexico
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] A subunit of polymerase, p66 promotes translesion DNA synthesis independently of polymerase pathway.2014
- Author(s)
  Hirota K, Yoshikiyo K, Murai J, Tsuda M, Takeda S
- Organizer
  International Symposium on Xeroderma Pigmentosum and Related Diseases: Disorders of DNA Damage Response -Bench to Bedside-
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Stereospecific trapping of PARP-DNA complexes by BMN 673 and comparison with olaparib and rucaparib.2013
- Author(s)
  Murai J, Huang SN, Renaud A, Zhang Y, Ji J, Takeda S, Morris J, Teicher B, Doroshow JH, Pommier Y
- Organizer
  第22回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] The non-ubiquitylation and catalytic functioning of the RAD18 and RNF8 E3 ubiquitin ligases have substantial overlapping roles in SDB repaor and genome maintenance.2013
- Author(s)
  Takeda S, Kobayashi S, Hirota K
- Organizer
  The 5th EMBO Meeting 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] DNA二重鎖切断末端の削り込みにおけるCtIPとDna2による協調的な働き2013
- Author(s)
  笹沼博之, Nguyen Ngoc Hoa, 小林純也, 小村将人, 津田雅貴, 廣田耕志, 小松賢志, 武田俊一
- Organizer
  第22回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] A novel bioassay to detect carbon nanotube-induced genotoxicity Mohiuddin, Islam Shamima Keka, Terry Jhon Evans, Hiroyasu Shimizu, Ko2013
- Author(s)
  ichi Kono, Shunichi Takeda
- Organizer
  Seishiro Hirano 28th RBC-NIRS INTERNATIONAL SYMPOSIUM
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22390126
[Presentation] Mutants deficient in DNA repair pathways provide high throughput assays for genotoxicity of chemicals and contribute to development of in silico methods for predicting genotoxicity of chemicals from their structure.2013
- Author(s)
  Takeda S
- Organizer
  FAOBMB Conference 2013
- Place of Presentation
  Dakka, Bangladish
- Invited
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 遺伝学的手法を応用した、新規抗がん剤のスクリーニングとその作用機序の解析2013
- Author(s)
  武田　俊一
- Organizer
  金沢大学薬学シンポジウム2012 -DNA損傷応答を標的とした革新的がん創薬研究-
- Place of Presentation
  金沢
- Invited
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 遺伝子破壊ニワトリ B リンパ球を用いたクロロ酢酸の DNA 障害とアポトーシス阻害の検討2013
- Author(s)
  清水宏泰、モヒウディン、武田俊一、河野公一
- Organizer
  第83回日本衛生学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22390126
[Presentation] 遺伝学的手法を応用した、新規抗がん剤のスクリーニングとその作用機序の解析2013
- Author(s)
  武田俊一
- Organizer
  金沢大学薬学シンポジウム2012-DNA損傷応答を標的とした革新的がん創薬研究-
- Place of Presentation
  金沢
- Year and Date
  2013-02-19
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] DNA二重鎖切断末端修飾におけるCtIPとDna2蛋白質の機能解析2013
- Author(s)
  笹沼博之, Nguyen Ngoc Hoa, 小林純也, 小村将人, 津田雅貴, 廣田耕志, 小松賢志, 武田俊一
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3' single-stranded ends at double-strand breaks in homologous recombination.2013
- Author(s)
  Sasanuma H, Nguyen NH, Kobayashi J, Omura M, Tsuda M, Hirota K, Komatsu K, Takeda S
- Organizer
  RBC Symposium
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 遺伝学的手法を応用した、新規抗がん剤のスクリーニングとその作用機序の解析2013
- Author(s)
  武田　俊一
- Organizer
  金沢大学薬学シンポジウム2012 -DNA損傷応答を標的とした革新的がん創薬研究-
- Place of Presentation
  金沢
- Invited
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3’ single-stranded ends at double-strand breaks in homologous recombination.2013
- Author(s)
  Takeda S, Nguyen NH, Sasanuma H
- Organizer
  2013 FASEB Science Research Conferences, Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Genetic models for DNA repair and cancer2012
- Author(s)
  Takeda S
- Organizer
  Tenth CMC Winter Symposium, Cellular and Molecular Medicine, Cancer, Stem Cells & Inflammation
- Place of Presentation
  Christian Medical College, Vellore, India(招待講演)
- Year and Date
  2012-01-06
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Genetic and Biocheical evidence for translesion DNA synthesis by replicative DNA polymerase delta2012
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference, Mutagenesis
- Place of Presentation
  Newport, USA
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Rad51AP1, Rad54 and Rad54B play an overlapping role in strand exchange in homologous DNA recombination, and are essential for genome maintenance in higher eukaryotes2012
- Author(s)
  Takeda S
- Organizer
  EMBO Workshop, Recombination Mechanisms and Genome Instability
- Place of Presentation
  Jerez de la Frontera, Spain
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Xpf and Mus81 are requiredto process homologous recombinationintermediates2012
- Author(s)
  Takeda S
- Organizer
  EMBO Workshop,Structure-specific nucleases in DNAreplication and repair
- Place of Presentation
  Hyeres, France.
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] Xpf and Mus81 are required to process homologous recombination intermediates2012
- Author(s)
  Takeda S
- Organizer
  EMBO Workshop, Structure-specific nucleases in DNA replication and repair
- Place of Presentation
  Hyeres, France
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] Genetic and Biocheical evidence for translesion DNA synthesis by replicative DNA polymerase delta2012
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference, Mutagenesis
- Place of Presentation
  Newport, USA
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] Genetic and Biocheicalevidence for translesion DNAsynthesis by replicative DNApolymerase delta2012
- Author(s)
  Takeda S
- Organizer
  Gordon ResearchConference, Mutagenesis
- Place of Presentation
  Newport, USA
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] The complex functional relationship between the RAD18 and RNF8 E3 ubiquitin lieases in DNA-damage responses2012
- Author(s)
  Takeda S, Kobayashi S, Hirota K
- Organizer
  The Sixth International Conference, SUMO, Ubiquitin, UBL Proteins : Implications for Human
- Place of Presentation
  The University of Texas MD Anderson Cancer Center, Houston, USA
- Year and Date
  2012-02-09
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Xpf and Mus81 are required to process homologous recombination intermediates2012
- Author(s)
  Takeda S
- Organizer
  EMBO Workshop, Structure-specific nucleases in DNA replication and repair
- Place of Presentation
  Hyeres, France
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Analysis of homologous recombination using the chicken B cell line, DT402012
- Author(s)
  Takeda S
- Organizer
  IFOM-Kyoto University Joint Symposium, Mechanisms of cell transformation and metastasis
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Complex functionalrelationship of the UBC13 E2ubiquitin conjugating enzyme, and theRAD18 and RNF8 E3 ubiquitin ligases,FASEB Summer Research Conferences2011
- Author(s)
  Takeda S
- Organizer
  Genetic Recombination & GenomeRearrangements
- Place of Presentation
  Steamboat Springs, USA
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] Reverse Genetic study of Structure-Specific-Endonucleases, FAN1, MUS81, and XPF in Homologous Recombination and Fanconi Anemia Repair Pathways2011
- Author(s)
  Kikuchi K, et al., Takeda S
- Organizer
  Responses to DNA damage : from molecular mechanism to human disease
- Place of Presentation
  Egmond aan Zee, The Netherlands
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 産業現場で使用される有害化学物質スクリーニングとしてのニワトリBリンパ球(DT40)によるバイオアッセイの確立2011
- Author(s)
  清水宏泰、栗田晃宏、Mohiuddin、武田俊一、河野公一
- Organizer
  近畿産業衛生学会
- Place of Presentation
  奈良県
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22390126
[Presentation] 産業現場で使用される有害化学物質スクリーニングとしてのニワトリBリンパ球(DT40)によるバイオアッセイの確立2011
- Author(s)
  清水宏泰、武田俊一, 他と河野公一
- Organizer
  第51回近畿産業衛生学会
- Place of Presentation
  奈良県文化会館(奈良県)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] SLX4 Links Fanconi Anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair2011
- Author(s)
  武田俊一
- Organizer
  Keystone Symposia, Genomic Instability and DNA Repair
- Place of Presentation
  Keystone, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Complex functional relationship of the UBC13 E2 ubiquitin conjugating enzyme, and the RAD18 and RNF8 E3 ubiquitin ligases.2011
- Author(s)
  Takeda S, Kobayashi S
- Organizer
  FASEB Summer Research Conferences, Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Steamboat Springs（アメリカ）
- Data Source
  KAKENHI-PROJECT-23659152
[Presentation] SLX4 Links Fanconi Anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair.2011
- Author(s)
  Takeda S.
- Organizer
  Keystone Symposia, Genomic Instability and DNA Repair
- Place of Presentation
  Keystone, Colorado, USA
- Year and Date
  2011-01-31
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Complex functional relationship of the UBC13 E2 ubiquitin conjugating enzyme, and the RAD18 and RNF8 E3 ubiguitin ligases2011
- Author(s)
  Takeda S, Kobayashi S
- Organizer
  FASEB Summer Research Conferences, Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Mutants deficient in DNA repair pathways provide high throughput assays for genotoxicity of chemicals and contribute to development of in silico methods for predicting genotoxicity of chemicals from their structure2011
- Author(s)
  Takeda S
- Organizer
  International Scientific Conference, Regenerative Medicine and Healthy Aging
- Place of Presentation
  Center for Life Sciences of Nazarbayev University, Astana, Kazakhstan(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Analysis of Immunoglobulin V Gene Diversification in the Chicken DT40 B Lymphocyte Line Reveals the Role of DNA Polymerases in Homologous Recombination and Translesion DNA Synthesis2010
- Author(s)
  Takeda S
- Organizer
  International Conference on Radiation and Cancer Biology at Nagasaki 2010
- Place of Presentation
  Nagasaki University, Nagasaki(長崎県)
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Analysis of Immunoglobulin V Gene Diversification in the Chicken DT40 B Lymphocyte Line Reveals the Role of DNA Polymerases in Homologous Recombination and Translesion DNA Synthesis2010
- Author(s)
  Takeda S
- Organizer
  International Conference on Radiation and Cancer Biology at Nagasaki 2010
- Place of Presentation
  Nagasaki University, Nagasaki(長崎県)
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Interactions between the RNF8 and RAD18 " Differential Functional E3 ubiquitin ligases in Translesion DNA Synthesis and DSB Repair "2010
- Author(s)
  Takeda S
- Organizer
  EMBO-Recombination Mechanism
- Place of Presentation
  Il Ciocco, Italy(発表予定だったが、直前に家族の事情によりキャンセル)
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Differential Functional interactions between the RNF8 and RAD18 E3 ubiquitin ligases in Translesion DNA Synthesis and DSB Repair.2010
- Author(s)
  Takeda S.
- Organizer
  EMBO Workshop, The Interface between the Ubiquitin Family and the DNA Damage Response
- Place of Presentation
  Rovinj, Croatia
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Analysis of Immunoglobulin V Gene Diversification in the Chicken DT40 B Lymphocyte Line Reveals the Role of DNA Polymerases in Homologous Recombination and Translesion DNA Synthesis2010
- Author(s)
  武田俊一
- Organizer
  International Conference on Radiation and Cancer Biology at Nagasaki 2010(招待講演)
- Place of Presentation
  Nagasaki University, Nagasaki
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Differential Functional interactions between the RNF8 and RAD18 E3 ubiquitin ligases in Translesion DNA Synthesis and DSB Repair2010
- Author(s)
  武田俊一
- Organizer
  EMBO Workshop, The Interface between the Ubiquitin Family and the DNA Damage Response
- Place of Presentation
  Rovinj, Croatia
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A novel approach using DNA repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of chemical compounds and environmental contaminants2009
- Author(s)
  武田俊一
- Organizer
  Chromosome Dynamics and Genome Stability(Invited)
- Place of Presentation
  Villars sur Ollon, Switzerland
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] DNAを損傷するタイプの抗がん治療時に機能するDNA修復分子2009
- Author(s)
  武田俊一
- Organizer
  癌学会学術総会
- Place of Presentation
  パシフィコ横浜, 横浜, (神奈川県)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A Critical Role for the Ubiquitin-Conjugating Enzymes Ubc13 and RNF8 in Homologous Recombination2009
- Author(s)
  武田俊一
- Organizer
  Gordon Research Conference(Invited)
- Place of Presentation
  Ventura,USA
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] DNAを損傷するタイプの抗がん治療時に機能するDNA修復分子2009
- Author(s)
  武田俊一
- Organizer
  癌学会学術総会
- Place of Presentation
  パシフィコ横浜,横浜,(神奈川)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Reverse Genetic Study of RAD51 mediators, BRCAI, BRCA2, RAD51 paralogs, RAD52, Swsl and Sfrl2009
- Author(s)
  Takeda S
- Organizer
  FASEB Genetic Recombination and Genome Rerrangements
- Place of Presentation
  Snowmass Village, Colorado(アメリカ)
- Year and Date
  2009-08-06
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Regulation of DNA damage response by ubiquitin ligases2009
- Author(s)
  武田俊一
- Organizer
  DNA Repair(Invited)
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] response by ubiquitin ligases " DNA2009
- Author(s)
  Takeda S
- Organizer
  Regulation of DNA damage Repair
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Reverse Genetic Study of RAD51 mediators, BRCA1, BRCA2, RAD51 paralogs, Rad52, Sws1, and Sfr12009
- Author(s)
  Takeda S
- Organizer
  FASEB Genetic Recombination and Genome Rerrangements
- Place of Presentation
  Snowmass Village, Colorado(アメリカ)
- Year and Date
  2009-08-06
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A Critical Role, for the Ubiquitin-Conjugating Enzymes-Ubc13 and RNF8 in Homologous Recombination2009
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura(アメリカ)
- Year and Date
  2009-02-10
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Systematic Reverse Genetic Study of DNA Damage Response, Using the Chicken DT40 Cells2009
- Author(s)
  Takeda S
- Organizer
  Annual Meeting of the Korean Society for Molecular and Cellular Biology
- Place of Presentation
  COEX Center, Seoul(韓国)
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] RAD51 mediators, BRCA1, BRCA2, RAD51 "Reverse Genetic Study of paralogs, RAD52, Sws1, and Sfr1"2009
- Author(s)
  Takeda S
- Organizer
  FASEB Genetic Recombination and Genome Rerrangements
- Place of Presentation
  Snowmass Village, Colorado, USA
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] DNA polymerases in TLS" Gordon Research "Reverse Genetic Analysis of Conference2009
- Author(s)
  Takeda S
- Organizer
  Colby-Sawyer College, New London
- Place of Presentation
  New Hampshire, USA
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Analysis of Genome Maintenance Using Chemical Genetics2009
- Author(s)
  武田俊一
- Organizer
  金沢がん生物学国際シンポジウム2009
- Place of Presentation
  金沢(石川)
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Chemical Genetic Method to Detect Environmental Mutagens and to Screen Anti-Malignant Chemical Compounds2009
- Author(s)
  武田俊一
- Organizer
  The 40th International Symposium of the Princess Takamatsu Cancer Research Fund(Invited)
- Place of Presentation
  Hotel Grand Palace, Tokyo
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] repair-deficient chicken DT40 cell "A novel approach using DNA lines for screening and characterizing the genotoxicity of chemical compounds and environmental contaminants"2009
- Author(s)
  Takeda S
- Organizer
  Chromosome Dynamics and Genome Stability, Villars sur Ollon
- Place of Presentation
  Switzerland
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Regulation of DNA damage response by ubiquitin ligases2009
- Author(s)
  Takeda S
- Organizer
  DNA Repair
- Place of Presentation
  クレタ島(ギリシャ)
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Chemical Genetic Method to Detect Environmental Mutagens and to Screen Anti-Malignant Chemical Compounds2009
- Author(s)
  Takeda S
- Organizer
  The 40th International Symposium of the Princess Takamatsu Cancer Research Fund
- Place of Presentation
  Hotel Grand Palace(東京都)
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Reverse Genetic Analysis of DNA polymerases in TLS2009
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Colby-Sawyer College, New London, New Hampshire(アメリカ)
- Year and Date
  2009-08-11
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Analysis of Genome Maintenance Using Chemical Genetics2009
- Author(s)
  武田俊一
- Organizer
  金沢がん生物学国際シンポジウム2009
- Place of Presentation
  金沢(石川)
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A novel approach using DNA repair-deficient chicken DT40 cell lines for screening and char acterizing the genotoxicity of chemical compounds and environmental contaminants2009
- Author(s)
  Takeda S
- Organizer
  Chromosome Dynamics and Genome Stability
- Place of Presentation
  Villars sur Ollon(スイス)
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Detect Environmental Mutagens and to "Chemical Genetic Method to Screen Anti-Malignant Chemical Compounds "2009
- Author(s)
  Takeda S
- Organizer
  The 40th International Symposium of the Princess Takamatsu Cancer Research Fund
- Place of Presentation
  Hotel Grand Palace, Tokyo
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Systematic Reverse Genetic Study of DNA Damage Response, Using the Chicken DT40 Cells2009
- Author(s)
  武田俊一
- Organizer
  Annual Meeting of the Korean Society for Molecular and Cellular Biology(Invited)
- Place of Presentation
  COEX Center, Seoul, Korea
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Analysis of Genome Maintenance Using Chemical Genetics2009
- Author(s)
  武田俊一
- Organizer
  International Symposium on Tumor Biology in Kanazawa 2009(金沢がん生物学国際シンポジウム2009)(招待講演)
- Place of Presentation
  金沢,石川
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Systematic Reverse Genetic Study of DNA Damage Response, Using the Chicken DT40 Cells2009
- Author(s)
  Takeda S
- Organizer
  Annual Meeting of the Korean Society for Molecular and Cellular Biology
- Place of Presentation
  COEX Center, Seoul(韓国)
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Chemical Genetic Method to Detect Environmental Mutagens and to Screen Anti-Malignant Chemical Compounds2009
- Author(s)
  Takeda S
- Organizer
  The 40th International Symposium of the Princess Takamatsu Cancer Research Fund
- Place of Presentation
  Hotel Grand Palace(東京都)
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] DNAを損傷するタイプの抗がん治療時に機能するDNA修復分子2009
- Author(s)
  武田俊一
- Organizer
  第68回癌学会学術総会,パシフィコ横浜(招待講演)
- Place of Presentation
  横浜,神奈川
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Ubiquitin-Conjugating Enzymes Ubc13 and " A Critical Role for the RNF8 in Homologous Recombination "2009
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, USA
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A novel approach using DNA repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of chemical compounds and environmental contaminants2009
- Author(s)
  Takeda S
- Organizer
  Chromosome Dynamics and Genome Stability
- Place of Presentation
  Villars sur Ollon(スイス)
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Regulation of DNA damage response by ubiquitin ligases2009
- Author(s)
  Takeda S
- Organizer
  DNA Repair
- Place of Presentation
  クレタ島(ギリシャ)
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A Critical Role for the Ubiquitin-Conjugating Enzymes Ubcl3 and RNF8 in Homologous Recombination2009
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura (アメリカ)
- Year and Date
  2009-02-10
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Reverse Genetic Analysis of DNA polymerases in TLS2009
- Author(s)
  武田俊一
- Organizer
  Gordon Research Conference, Colby-Sawyer College(Invited)
- Place of Presentation
  New London, New Hampshire, USA
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Reverse Genetic Study of RAD51 mediators, BRCA1, BRCA2, RAD51 paralogs, RAD52, Sws1, and Sfr12009
- Author(s)
  武田俊一
- Organizer
  FASEB Genetic Recombination and Genome Rerrangements(Invited)
- Place of Presentation
  Snowmass Village, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Reverse Genetic Analysis of DNA polymerases in TLS2009
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Colby-Sawyer College, New London, New Hampshire(アメリカ)
- Year and Date
  2009-08-11
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] The role of antirecombination in replication-fork collapse2008
- Author(s)
  武田俊一
- Organizer
  Molecular and Clinical Mechanisms in Bloom's Syndome and Related Diosorders(Invited)
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] ニワトリBリンパ細胞を使ったDNA損傷応答機構の遺伝学的解析2008
- Author(s)
  武田俊一
- Organizer
  放射線防護センターシンポジウム
- Place of Presentation
  稲毛(千葉)
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A critical role for the ubiquitin-conjugating enzymes Ubc13 and RNF8 in homologous recombination2008
- Author(s)
  武田俊一
- Organizer
  3R Symposium 2008
- Place of Presentation
  つま恋(静岡)
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] ニワトリBリンパ細胞を使ったDNA損傷応答機構の遺伝学的解析2008
- Author(s)
  武田俊一
- Organizer
  放射線防護センターシンポジウム(招待講演)
- Place of Presentation
  稲毛,千葉
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Collaboration of BRCA1 and CtIP in cellular tolerance to topoisomerase poisons2008
- Author(s)
  Takeda S
- Organizer
  Gordon Research Conference
- Place of Presentation
  Oxford (イギリス)
- Year and Date
  2008-07-22
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Collaboration of BRCA1 and CtIP in cellular tolerance to topoisomerase poisons2008
- Author(s)
  武田俊一
- Organizer
  Gordon Research Conference(Invited)
- Place of Presentation
  Oxford, UK
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A critical role for the ubiquitin-conjugating enzymes Ubcl3 and RNF8 in homologous recombination2008
- Author(s)
  武田俊一
- Organizer
  3R Symposium 2008
- Place of Presentation
  つま恋(静岡)
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] The role of anti-recombination in replication-fork collapse2008
- Author(s)
  Takeda S
- Organizer
  Molecular and Clinical Mechanisms in Bloom's Syndomeand Related Diosorders
- Place of Presentation
  Chicago (アメリカ)
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Multiple functions of Mre11/Rad50/Nbs1 complex2008
- Author(s)
  武田俊一
- Organizer
  2008 EMBO Recombination Mechamisms(Invited)
- Place of Presentation
  Il Ciocco, Italy
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Multiple functions of Mrell/Rad50/Nbs1 complex2008
- Author(s)
  Takeda S
- Organizer
  2008 EMBO Recombination Mechamisms
- Place of Presentation
  II Ciocco (イタリア)
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A critical role for the ubiquitin-conjugating enzymes Ubc13 and RNF8 in homologous recombination2008
- Author(s)
  武田俊一
- Organizer
  3R Symposium 2008(招待講演)
- Place of Presentation
  つま恋,静岡
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A critical role for the ubiquitin-conjugating eniymes Ubc13 and RNF8 in homologous recombination2008
- Author(s)
  Takeda S
- Organizer
  Genome Stability in Health and Disease
- Place of Presentation
  Tel Aviv(イスラエル)
- Year and Date
  2008-09-23
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A critical role for the ubiquitin-conjugating enzymes Ubc13 and RNF8 in homologous recombination2008
- Author(s)
  武田俊一
- Organizer
  Genome Stability in Health and Disease(Invited)
- Place of Presentation
  Tel Aviv, Israel
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] Multiple functions of Mie11/Rad50/Nbs1 complex2008
- Author(s)
  Takeda S
- Organizer
  2008 EMBO Recombination Mechamisms
- Place of Presentation
  I1 Ciocco (イタリア)
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] BRCA1-CTIP complex plays a novel role in cellular tolerance to double-strand breaks associated with polypeptides in the presence of topoisomerase poisons.2008
- Author(s)
  Takeda S, Nakamura K, Taniguchi Y
- Organizer
  Abcam, Maintenance of Genome Stability Conference 2008
- Place of Presentation
  Puerto Vallarta, Mexico
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] ニワトリByンパ細胞を使ったDNA損傷応答機構の遺伝学的解析2008
- Author(s)
  武田俊一
- Organizer
  放射線防護センターシンポジウム
- Place of Presentation
  稲毛(千葉)
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] A critical role for the ubiquitin-conjugating enzymes Ubc13 and RNF8 in homologous recombination2008
- Author(s)
  Takeda S
- Organizer
  Genome Stability in Health and Disease
- Place of Presentation
  Tel Aviv (イスラエル)
- Year and Date
  2008-09-23
- Data Source
  KAKENHI-PROJECT-20241012
[Presentation] 遺伝子破壊メダカ作製系の樹立,淡路,兵庫,5月17日,2007.(招待、特別講演)2007
- Author(s)
  武田俊一
- Organizer
  第5回幹細胞シンポジウム
- Place of Presentation
  兵庫県淡路市
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A critical role for the ubiquitin-conjugating enzyme UBC13 in initiating homologous recombination.2007
- Author(s)
  Takeda S
- Organizer
  FASEB Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Snowmass Village, Colorado, USA
- Year and Date
  2007-07-29
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination2007
- Author(s)
  Takeda S
- Organizer
  CNIO Cancer Conferences
- Place of Presentation
  Madrid, Spain,
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-17013039
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  Sasanuma H, Takeda S
- Organizer
  The 9th 3R Symposium Together with National Institute of Genetics “2014 International Symposium” “3R and beyond”
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 複製ポリメラーゼδPOLD3/p66サブユニットはポリメラーゼζ経路と独立に損傷乗り越えに寄与する
- Author(s)
  廣田耕志、村井純子、Guillaume Guilbaud、津田雅貴、成田岳雄、西原佳那、笹沼博之、釣本俊樹、Julian Sale、武田俊一
- Organizer
  染色体ワークショップ
- Place of Presentation
  広島
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  Sasanuma H, Takeda S
- Organizer
  Keystone Symposia, DNA Replication and Recombination
- Place of Presentation
  Whistler, British Columbia, Canada
- Year and Date
  2015-03-01 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] RNF4は染色体ロスを防止する
- Author(s)
  高木季代、津田雅貴、村井純子、武田俊一、廣田耕志
- Organizer
  染色体ワークショップ
- Place of Presentation
  広島
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] SUMO化タンパク質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)の活性維持と染色体ロスの防止
- Author(s)
  廣田耕志、高木季代、津田雅貴、村井純子、Keka Islam、成田岳雄、藤田真梨、笹沼博之、小林純也、武田俊一
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] The p66 subunit of DNA polymerase δ promotes translesion synthesis independently of DNA polymerase ζ.
- Author(s)
  Hirota K, Sale J.E., Takeda S
- Organizer
  ZING Conferences, DNA Polymerases: Biology, Diseases an Biomedical Applications
- Place of Presentation
  Cambridge, UK
- Year and Date
  2014-08-31 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  武田俊一、笹沼博之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-23221005

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Takeda Shunichi 武田 俊一

TAKEDA Shunichi 武田 俊一

武田 俊一

Research Projects

Research Products

Co-Researchers

Identification of the enhancer sequences that are controlled by androgen receptor

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Review Section

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Genome-wide identification of double-strand break sites induced by activated estrogen receptors and Topoisomerase IIBetaPrincipal Investigator

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ヒトゲノム編集細胞を使った、化学物質の薬理作用・有害性を解析するシステムの構築Principal Investigator

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Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism CharacterizationPrincipal Investigator

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Genome-wide identification of DNA replication origin sequences in human cellsPrincipal Investigator

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Development of a method for increasing gene-targeting efficiency in human cellsPrincipal Investigator

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Establishment of high-throughput screening of toxic chemical compounds.Principal Investigator

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遺伝子破壊細胞を使った、化学物質の生物効果をハイスループットに解析するシステムPrincipal Investigator

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Comprehensive Analysis of Ubiquitome during DNA damage responsePrincipal Investigator

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Assessment of combined effect of chemicals with using mutant DT40s and gene knock out Medaka.

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Analysis of DNA damage response using gene-disrupted DT40 clones.Principal Investigator

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細胞周期を制御するCDK1のケミカル条件変異ヒト細胞株の樹立と表現型解析Principal Investigator

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Transgenic animal model showing genomic instabilities like human hypervariable minisatellite and its applications in forensic genetics.

Principal Investigator

Takeda Shunichi 武田俊一

TAKEDA Shunichi 武田俊一

武田俊一