Kitamura Yoshihisa 北村佳久

… Alternative Names

KITAMURA Yoshihisa 北村佳久

北村佳久キタムラヨシヒサ

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Researcher Number	60195295
Other IDs
External Links
Affiliation (Current)	2025: 立命館大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 立命館大学, 薬学部, 教授 2018 – 2023: 立命館大学, 薬学部, 教授 2015: 立命館大学, 薬学部, 教授 2014: 京都薬科大学, 病態生理学分野, 准教授 2012 – 2014: 京都薬科大学, 薬学部, 准教授 … More 2004 – 2005: 京都薬科大学, 薬学部, 助教授 2000 – 2003: 京都薬科大学, 薬学部・病態生理学, 助教授 2001 – 2002: 京都薬科大学, 薬学部, 助教授 1996 – 1998: 京都薬科大学, 薬学部・病態生理学, 助教授 1994: Toyama Medical and Pharmaceutical University Associate Professor, 助教授 1994: 京都薬科大学, 薬学部, 助教授 1991 – 1993: Hokkaido Univ. ・Fac. Pharmac. Sci. ・Assistant, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Biological pharmacy / Pharmacology in pharmacy / Neurochemistry/Neuropharmacology Except Principal Investigator Neurology / 応用薬理学・医療系薬学 / Biological pharmacy / Medical pharmacy / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator ミクログリア / アルツハイマー病 / アストロサイト / パーキンソン病 / DJ-1結合化合物 / 神経細胞死 / α-シヌクレイン / DJ-1 / PARK7 / Microglia … More / 神経変性疾患 / アポトーシス / シナプス可塑性 / 神経細胞 / 一酸化窒素(NO) / ストレスセンサーDJ-1 / C57BL マウス / マウスBV-2ミクログリア細胞 / ヒト神経芽細胞腫 SH-SY5Y細胞 / BV-2ミクログリア細胞 / PARK7 (DJ-1) / 線条体 / C57BLマウス / pre-formed fibril (PFFs） / シヌクレイノパチー / 酸化ストレスセンサー / 神経保護作用 / PARK7/DJ-1 / αシヌクレイン / Brain ischemia / Subthalamic nucleus / Parkinson's disease / Nigro-striatal pathway / Dopaminergic neurons / Neural precursors / Mouse embryonic stem cells / アミロイドβ / 脳梗塞 / 神経幹細胞 / 視床下核 / 黒質-線条体 / ドパミンニューロン / 胚性幹細胞 / Alzheimer's disease / Amyloid-β clearance / Small GTPases / WASP family / Actin reorganization / Phagocytosis / Amyloid-β(1-42) / アミロイドβクリアランス / アクチン重合 / 形態変化 / ファゴサイトーシス / WASPファミリー蛋白質 / 低分子量GTP結合蛋白質 / Novel Parkinsonian Flatworm Model / Neurodegeneration / Caspase Inhibitors / Dopaminergic Reagents / MPTP / Rotenone / Invertebrate Flatworm / Planarian (Dugesia japonica) / 脳傷害モデル / 扁形動物 / 修復・再生 / 脳障害モデル / プラナリア / 扇形動物 / 多能性幹細胞 / 神経再生 / 神経保護 / DJ-1結合タンパク質 / ニコチン受容体 / 抗酸化作用 / DJ-1タンパク質 / NO合成酵素(NOS) / p53蛋白質 / STAT1 / NF-κB / 転写因子 / カイニン酸 / 脳虚血 / ヘムオキシゲナーゼ / 一酸化窒素合成酵素 / ラット / 海馬 / 主要組織適合性遺伝子複合体(MHC) / 誘導型NO合成酵素(iNOS) / ヒト神経芽細胞腫SH-SY5Y / NADPHジアホラーゼ / 免疫組織化学 / 抗nNOS抗体 / 誘導型一酸化窒素合成酵素(iNOS) / 神経型一酸化窒素合成酵素(nNOS) / サイトカイン / エンドトキシン / グリア細胞 / NOシンターゼ … More Except Principal Investigator アルツハイマー病 / 老化促進マウス / 薬効評価法 / 予防治療薬 / ミクログリア / 神経細胞 / 酸化ストレス / cytokine / high mobility group protein-1 (HMG1) / heat-shock protein (HSP) / BiP (GRP78) / clearance / amyloid-β / microglia / Alzheimer's disease / GRP78 / BiP / PI3Kinase / 神経保護 / ニコチン性受容体 / preseniliu-1 / Aβ / high-mobility group protein-1 / heat-shock protein / c. elegaus / サイトカイン / クリアランス / high mobility group protein-1(HMG1) / heat shock protein(HSP) / Bip(GRP78) / β-アミロイド / Neurochmistry / Pharmacology / Screening / Herbs / Therapeutics / Memory disturbance / Mouse / Aging / プロテインキナーゼC / GABA受容体 / NMDA型グルタミン酸受容体 / M_1ムスカリン受容体 / 海馬 / 脳機能障害 / 神経伝達物質受容体 / 脳内機序 / 薬理学 / 神経化学 / 薬効評価 / 和漢薬 / 老化 / 記憶障害 / 老化促進モデルマウス / Second messengers / Senescent accelerated mice / Oriental medicines / Glutamate-receptor / alpha_2-receptor / Screening methods / Nootropic / Senile dementia / cyclic AMP / アデノシン受容体 / 二次メッセンジャ- / 生薬成分 / グルタミン酸受容体 / α_2受容体 / 老人痴呆 / 骨髄幹細胞 / 脳神経疾患 / トランスレーショナルリサーチ / 痴呆 / 神経科学 / 移植・再生医療 / ノックアウトマウス / 質量分析 / HRD1 / Dorfin / RNF1９B / EDAD / 小胞体ストレス / 小胞体 / エンドソーム / RNF19B / 膜輸送 / γ-セクレターゼ / ERAD / アミロイドβ / APP / ユビキチンリガーゼ Less

酸化ストレスセンサーDJ-1をターゲットとした脳神経変性疾患の薬理学的創薬研究Principal Investigator
- Principal Investigator
  
  北村佳久
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Ritsumeikan University
Pharmacological study of stress sensor DJ-1 on neurodegenerative disorder synucleinopathyPrincipal Investigator
- Principal Investigator
  
  Kitamura Yoshihisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Ritsumeikan University
Developmental drug study targeting PARK7/DJ-1, a causetive gene of familial Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Kitamura Yoshihisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Ritsumeikan University
Study of oxydative stress sensor DJ-1 for therapeutic target of neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Kitamura Yoshihisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Ritsumeikan University
  Kyoto Pharmaceutical University
Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent
- Principal Investigator
  
  Nomura Yasuyuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kurume University
  Yokohama College of Pharmacy
Transplantation of bone marrow-derived microglia-like cells for the new cell therapy against Alzheimer's disease
- Principal Investigator
  
  TAKATA Kazuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Glial Cell Therapy Using Neuroprotective effects of GliaPrincipal Investigator
- Principal Investigator
  
  KITAMURA Yoshihisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
The Study of Cell Polarity, Movement and Unfolded Protein Phagocytosis in Brain Glial CellsPrincipal Investigator
- Principal Investigator
  
  KITAMURA Yoshihisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Neureu-glia interaction in Alzheimer's disease
- Principal Investigator
  
  SHIMOHAMA Shou
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
The Study of Neuroprotection and Regeneration on Neurodegenerative Flatworm model using inverteverate PlanarianPrincipal Investigator
- Principal Investigator
  
  KITAMURA Yoshihisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
脳障害時におけるミクログリアおよびアストロサイトの機能変化の解析Principal Investigator
- Principal Investigator
  
  北村佳久
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
脳傷害時におけるグリア細胞のニューロン機能増悪作用Principal Investigator
- Principal Investigator
  
  北村佳久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
一酸化窒素合成酵素によるシナプス可塑性およびニューロン死調節機構の神経化学的研究Principal Investigator
- Principal Investigator
  
  北村佳久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto Pharmaceutical University
脳で誘導される一酸化窒素(NO)合成酵素のシナプス形成、神経細胞死への関与の機序Principal Investigator
- Principal Investigator
  
  北村佳久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Studies on the Machanism of Memory Disturbances in Senescence-Accelerated Mouse and the Application to Screening of Nootropics
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
Studies on screening methods for evaluation of novel nootropics and development of the drugs
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

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All Journal Article Presentation Book

[Book] 認知症plus予防教育2020
- Author(s)
  肱岡雅宣, 天ヶ瀬紀久子, 北村佳久.
- Total Pages
  216
- Publisher
  日本看護協会出版会
- ISBN
  9784818022485
- Data Source
  KAKENHI-PROJECT-18K06904
[Book] 臨床薬学テキストシリーズ第5巻［薬理・病態・薬物治療］『神経・筋・精神／麻酔・鎮痛』2019
- Author(s)
  北村佳久, 肱岡雅宣, 髙橋良輔.
- Total Pages
  372
- Publisher
  中山書店
- ISBN
- Data Source
  KAKENHI-PROJECT-18K06904
[Book] A survey of the molecular basis for the generation of functional dopaminergic neurons from pluripotent stem cells: Insights from regenerative biology and regenerative medicine. In: Neural Stem Cells (Ed. L. Bonfanti)2013
- Author(s)
  Kaneyasu Nishimura, Yoshihisa Kitamura, Kiyokazu Agata, and Jun Takahashi
- Publisher
  InTech Europe
- Data Source
  KAKENHI-PROJECT-25460109
[Book] Development of cell therapeutic strategies for Alzheimer’s disease using animal models. In: Animal Models in Human Disease: Applications, Outcomes and Controversies　（Ed. S.A. Murray)2013
- Author(s)
  Kazuyuki Takata, Shohei Kawanishi, Yumiko Touji, Tetsuya Takada, Yoshihisa Kitamura, and Eishi Ashihara
- Publisher
  NOVA Science Publishers
- Data Source
  KAKENHI-PROJECT-25460109
[Journal Article] The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells.2023
- Author(s)
  Fujimaki Ayaka、 Ohuchi Kazuki、 Takizawa Shinnosuke、 Murakmi Takanori、 Kurita Hisaka、 Hozumi Isao、 Wen Xiaopeng、 Kitamura Yoshihisa、 Wu Zhiliang、 Maekawa Yoichi、 Inden Masatoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 (1) Issue: 1 Pages: 15629-15629
- DOI
  10.1038/s41598-023-42903-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06586, KAKENHI-PLANNED-19H05767, KAKENHI-PROJECT-20H03478
[Journal Article] Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease2022
- Author(s)
  Takata Kazuyuki、Kimura Hiroyuki、Yanagisawa Daijiro、Harada Koki、Nishimura Kaneyasu、Kitamura Yoshihisa、Shimohama Shun、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 9 Pages: 2780-2780
- DOI
  10.3390/molecules27092780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07854, KAKENHI-PROJECT-21K06586, KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-20H03569
[Journal Article] Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage2022
- Author(s)
  Futokoro Risa, Hijioka Masanori, Arata Moe, Kitamura Yoshihisa
- Journal Title
  
  Brain Sciences
  
  Volume: 12 Issue: 2 Pages: 162-162
- DOI
  10.3390/brainsci12020162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-21K06586
[Journal Article] MEK/ERK Signaling Regulates Reconstitution of the Dopaminergic Nerve Circuit in the Planarian Dugesia japonica2021
- Author(s)
  Hijioka Masanori, Ikemoto Yusuke, Fukao Kosuke, Inoue Takeshi, Kobayakawa Tatsuki, Nishimura Kaneyasu, Takata Kazuyuki, Agata Kiyokazu, Kitamura Yoshihisa
- Journal Title
  
  Neurochemical Research
  
  Volume: － Issue: 9 Pages: 2558-2567
- DOI
  10.1007/s11064-020-03226-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-21K06586, KAKENHI-PROJECT-18K06341
[Journal Article] Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro.2021
- Author(s)
  Inden M, Takagi A, Kitai H, Ito T, Kurita H, Honda R, Kamatari YO, Nozaki S, Wen X, Hijioka M, Kitamura Y, Hozumi I
- Journal Title
  
  Int J Mol Sci. 22, 11484
  
  Volume: 22 Issue: 21 Pages: 11484-11484
- DOI
  10.3390/ijms222111484
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-21K06586, KAKENHI-PROJECT-20H04285
[Journal Article] Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.2020
- Author(s)
  Hijioka M, Futokoro R, Ohto-Nakanishi T, Nakanishi H, Katsuki H, Kitamura Y.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 85 Pages: 106678-106678
- DOI
  10.1016/j.intimp.2020.106678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-18K06904
[Journal Article] Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ2020
- Author(s)
  Kuroda E, Nishimura K, Kawanishi S, Sueyoshi M, Ueno F, Toji Y, Abo N, Konishi T, Harada K, Satake S, Shima C, Toda Y, Kitamura Y, Shimohama S, Ashihara E, Takata K.
- Journal Title
  
  Neuroscience
  
  Volume: 438 Pages: 217-228
- DOI
  10.1016/j.neuroscience.2020.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17388, KAKENHI-PROJECT-20H03569, KAKENHI-PROJECT-18K06904
[Journal Article] Peripheral blood-derived microglia-like cells decrease amyloid-β burden and ameliorate cognitive impairment in a mouse model of Alzheimer’s disease.2020
- Author(s)
  Kuroda E., Takata K., Nishimura K., Oka H., Sueyoshi M., Aitani M., Kouda A., Satake S., Shima C., Toda Y., Nakata S., Kitamura Y., and Ashihara E.
- Journal Title
  
  J. Alzheimers Dis.
  
  Volume: 73 (1) Issue: 1 Pages: 413-429
- DOI
  10.3233/jad-190974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06904, KAKENHI-PROJECT-19K08826, KAKENHI-PROJECT-19J15414
[Journal Article] Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke2020
- Author(s)
  Hijioka Masanori, Kitamura Kanori, Yanagisawa Daijiro, Nishimura Kaneyasu, Takata Kazuyuki, Inden Masatoshi, Kitamura Yoshihisa
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 144 Issue: 3 Pages: 183-187
- DOI
  10.1016/j.jphs.2020.07.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-18K06904
[Journal Article] Bone-marrow-derived microglia-like cells ameliorate brain amyloid pathology and cognitive impairment in a mouse model of Alzheimer's disease.2018
- Author(s)
  Kawanishi S., Takata K., Itezono S., Nagayama H., Konoya S., Chisaki Y., Toda Y., Nakata S., Yano Y., Kitamura Y., Ashihara E.
- Journal Title
  
  J. Alzheimer’s Dis.
  
  Volume: 64 Issue: 2 Pages: 563-585
- DOI
  10.3233/jad-170994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06904, KAKENHI-PROJECT-16K08286, KAKENHI-PROJECT-16K08722
[Journal Article] Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells.2016
- Author(s)
  Takada T, Takata K, Ashihara E.
- Journal Title
  
  J Physiol Sci
  
  Volume: 66 Pages: 74-81
- DOI
  10.1016/j.neuint.2016.02.008
- NAID
  40020922534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461436, KAKENHI-PROJECT-26860058, KAKENHI-PROJECT-25460109, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-15K16321
[Journal Article] DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease.2015
- Author(s)
  Takahashi-Niki K., Inafune A., Michitani N., Hatakeyama Y., Suzuki K., Sasaki M., Kitamura Y., Niki T, Iguchi-Ariga S.M., Ariga H..
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 127 Issue: 3 Pages: 305-310
- DOI
  10.1016/j.jphs.2015.01.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460109
[Journal Article] Temporal Changes of CD68 and α7 Nicotinic Acetylcholine Receptor Expression in Microglia in Alzheimer’s Disease-Like Mouse Models2015
- Author(s)
  Akihiro Matsumura, Syuuichirou Suzuki, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Hiromi Suzuki, Ayano Yamauchi, Kazuyuki Takata, Yoshihisa Kitamura and Shun Shimohama
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 44 Issue: 2 Pages: 409-423
- DOI
  10.3233/jad-141572
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659352, KAKENHI-PROJECT-15K09840, KAKENHI-PROJECT-25460109
[Journal Article] Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligaseimplicated in Alzheimer's disease2014
- Author(s)
  Saito R., Kaneko M., Kitamura Y., et al.
- Journal Title
  
  PLoS ONE
  
  Volume: 9巻 Issue: 5 Pages: 94576-94576
- DOI
  10.1371/journal.pone.0094576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J09807, KAKENHI-PROJECT-23790095, KAKENHI-PROJECT-24300135, KAKENHI-PROJECT-24590119, KAKENHI-PROJECT-24790085, KAKENHI-PROJECT-26460099
[Journal Article] Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease.2014
- Author(s)
  Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, and Yasuyuki Nomura
- Journal Title
  
  PLoS One
  
  Volume: 9 (5)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460109
[Journal Article] Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease2014
- Author(s)
  Saito R., Kaneko M., Kitamura Y.,Takata K., Kawada K., Okuma Y. and Nomura Y.
- Journal Title
  
  PLos One
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300135
[Journal Article] Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica.2014
- Author(s)
  Natsuka Tashiro, Kaneyasu Nishimura, Kanako Daido, Tomoe Oka, Mio Todo, Asami Toshikawa, Jun Tsushima, Kazuyuki Takata, Kanji Yoshimoto, Kiyokazu Agata, and Yoshihisa Kitamura
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 449 (4) Pages: 412-418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460109
[Journal Article] Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice2013
- Author(s)
  Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, Ariga H, Honmou O, Shimohama S
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 91 Issue: 1 Pages: 62-72
- DOI
  10.1002/jnr.23128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-PROJECT-23591404, KAKENHI-PROJECT-23659460, KAKENHI-PROJECT-24590222, KAKENHI-PROJECT-25460109
[Journal Article] 3-[(2,4-Dimethoxy)benzylidene]-anabasei nedihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats2013
- Author(s)
  Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S
- Journal Title
  
  J Neurosci Res.
  
  Volume: 91(3) Issue: 3 Pages: 462-71
- DOI
  10.1002/jnr.23160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-PROJECT-23659384, KAKENHI-PROJECT-23659460, KAKENHI-PROJECT-24659352, KAKENHI-PROJECT-25460109
[Journal Article] Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia.2005
- Author(s)
  Yoshihisa Kitamura et al.
- Journal Title
  
  Journal of Pharmacological Sciences 97・2
  
  Pages: 289-293
- NAID
  10025726277
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590071
[Journal Article] Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebro-ventricular injection of microglia.2005
- Author(s)
  Yoshihisa Kitamura et al.
- Journal Title
  
  Journal of Pharmacological Sciences 97(2)
  
  Pages: 289-293
- NAID
  10025726277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590071
[Journal Article] Intracerebroventricular injection of microglia protects against focal brain ischemia.2004
- Author(s)
  Yoshihisa Kitamura et al.
- Journal Title
  
  Journal of Pharmacological Sciences 94(2)
  
  Pages: 203-206
- NAID
  130000073874
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590071
[Journal Article] Intracerebroventricular injection of microglia protects against focal brain ischemia.2004
- Author(s)
  Yoshihisa Kitamura et al.
- Journal Title
  
  Journal of Pharmacological Sciences 94・2
  
  Pages: 203-206
- NAID
  130000073874
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590071
[Presentation] Reconstitutionof dopaminergic nerve circuit in planarian, an invertebrate flatworm2023
- Author(s)
  Matsubayashi Koto, Xiaopeng Wen, Hijioka　Masanori, Inoue Takeshi, Agata Kiyokazu, Kitamura Yoshihisa
- Organizer
  The 21st Takeda Science Foundation Symposium on Bioscence, Osaka, 2023.1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] Galantamine reduced α-synuclein aggregation by inducing autophagy activation of the α7-nicotinic acetylcholine receptors2023
- Author(s)
  Iwashita Natsumi, Wen Xiaopeng, Nozaki Sora, Hijioka Masanori, Kitamura Yoshihisa
- Organizer
  19th World Congress of Basic and Clinical Pharmacology, Glasgow
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] Reconstitutionof dopaminergic nerve circuit in planarian, an invertebrate flatworm2023
- Author(s)
  Matsubayashi Koto, Xiaopeng Wen, Hijioka　Masanori, Inoue Takeshi, Agata Kiyokazu, Kitamura Yoshihisa
- Organizer
  The 21st Takeda Science Foundation Symposium on Bioscence, Osaka
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] MEK/ERK signaling promotes the regeneration of dopaminergic never circuit in the planarian, an invertebrate flatworm2023
- Author(s)
  Wen Xiaopeng, Hijioka Masanori, Inoue Takeshi, Agata Kiyokazu, Kitamura Yoshihisa
- Organizer
  19th World Congress of Basic and Clinical Pharmacology, Glasgow
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] ガランタミンはオートファジーを活性化することによりα-シヌクレインタンパク質の凝集を抑制する2021
- Author(s)
  野﨑空, 肱岡雅宣, 岩下夏未, 難波純也, 文小鵬, 北村佳久
- Organizer
  第44回日本神経科学大会, 神戸（オンライン開催）
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] α-シヌクレイン凝集体のクリアランスにおけるガランタミンの作用解析2021
- Author(s)
  岩下夏未, 野﨑空, 肱岡雅宣, 文小鵬, 北村佳久
- Organizer
  第71回日本薬学会関西支部総会・大会, 大阪（オンライン開催）
- Data Source
  KAKENHI-PROJECT-21K06586
[Presentation] プラナリアにおけるドパミン神経の再生に関するアセチルコリンの作用解析2020
- Author(s)
  深尾昂佑, 肱岡雅宣, 北村佳久.
- Organizer
  第70回日本薬学会関西支部大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ニコチン性アセチルコリン受容体を介したガランタミンのα-シヌクレイン凝集抑制作用2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  第70回日本薬学会関西支部大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ヒト神経芽細胞腫SH-SY5Y細胞におけるα-シヌクレインタンパク質の細胞内凝集体形成に対するガランタミンの抑制作用2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  第43回日本神経科学大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] 半側性パーキンソン病モデルラットにおけるドパミン神経細胞死に対する 5-アミノレブリン酸の抑制作用2020
- Author(s)
  北村佳久, 肱岡雅宣, 北村叶里, 柳沢大治郎, 西村周泰, 高田和幸, 位田雅俊.
- Organizer
  第137回日本薬理学会近畿部会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ヒト神経芽細胞腫SH-SY5Y細胞におけるα-シヌクレイン凝集に対するガランタミンの作用.2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] LXA4受容体刺激は脳内出血モデルマウスの運動機能障害を軽減する.2020
- Author(s)
  懐理紗, 肱岡雅宣, 北村佳久.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] 脳内出血病態形成過程におけるロイコトリエンB4の機能解析.2019
- Author(s)
  肱岡雅宣, 懐理紗, 香月博志, 北村佳久.
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] MEK阻害薬によるプラナリアの個体再生およびドパミン神経再生の抑制.2019
- Author(s)
  深尾昂佑, 肱岡雅宣, 小早川達貴, 池本有佑, 北村佳久.
- Organizer
  第69回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Analysis of the functions of leukotriene B4 and lipoxin A4 to the neutrophil invasion into hematoma in vitro model of intracerebral hemorrhage.2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  Neuro2019 第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Leukotriene B4 secreted by microglia promotes neutrophil invasion into hematoma of mice with intracerebral hemorrhage.2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  第92回日本薬理学会年会（大阪）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Leukotriene B4-BLT1 axis exacerbates neutrophil invasion and motor dysfunction after intracerebral hemorrhage in mice.2018
- Author(s)
  Hijioka M., Kurauchi Y., Hisatsune A., Seki T., Koga T., Kitamura Y., Yokomizo T., Shimizu T. and Katsuki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] BV-2ミクログリアにおけるTLR2を介した炎症反応に対するDJ-1結合化合物の作用2018
- Author(s)
  尾上徹, 肱岡雅宣, 北村佳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018（福岡）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] アルツハイマー病モデルマウスの認知機能障害に対するDJ-1結合化合物の作用解析2018
- Author(s)
  柴慧司, 肱岡雅宣, 有賀寛芳, 北村佳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018（福岡）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] パーキンソン病モデルにおけるガランタミンのニコチン受容体を介した薬物旋回運動.2015
- Author(s)
  位田雅俊，北村佳久，下濱俊
- Organizer
  第127回日本薬理学会近畿部会
- Place of Presentation
  長良川国際会議場（岐阜県、岐阜市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] 由来がん細胞へホーミングするglioblastoma由来エクソソームの解析〜がん標的化技術応用のための指向性決定因子の探索〜2014
- Author(s)
  戸田侑紀、高田和幸、中川由布子、川上光、藤岡周助、小林数也、服部恭尚、北村佳久、赤路健一、芦原英司
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] A novel therapeutic target against Alzheimer's disease: HRD1 as endolplasmic reticulum stress-related ubiquitin ligase2014
- Author(s)
  Nomura Y, Kaneko M, Okuma Y, Kitamura Y, Takata Y, Nishi A
- Organizer
  13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy
- Place of Presentation
  Geneve, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-24300135
[Presentation] Microglia as a therapeutic target for Alzheimer's disease2014
- Author(s)
  Kazuyuki Takata, Yoshihisa Kitamura, Florent Ginhoux and Eishi Ahishira
- Organizer
  Monthly Neuroscience Seminar in Faculty of Medicine & Health Science, University Putra Malaysia
- Place of Presentation
  Faculty of Medicine & Health Science, University Putra Malaysia　(Serdang, Malaysia)
- Year and Date
  2014-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-24590222
[Presentation] Wnt/β-catenin 経路阻害化合物のスクリーニング系の構築2014
- Author(s)
  若林亮介、高田和幸、中村誠宏、大矢博己、菅倫子、川幡尚平、福田浩紀、赤路健一、松田久司、北村佳久、芦原英司
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] アルツハイマー病の細胞治療法の開発を目指した、骨髄由来細胞、ミクログリアおよびマクロファージの定性・機能解析2014
- Author(s)
  河西翔平、高田和幸、黒田絵莉子、杉野友紀、北村佳久、芦原英司
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] アルツハイマー病の細胞治療法開発に向けた骨髄由来細胞のAβ貪食機能と内在性ミクログリアへの作用解析2014
- Author(s)
  杜氏裕美子、高田和幸、河西翔平、高田哲也、北村佳久、下濱　俊、芦原英司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] パーキンソン病モデルマウスにおけるヒト由来幹細胞の神経保護作用2014
- Author(s)
  北村佳久、高田和幸、下濱　俊、芦原英司
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] リバスチグミンの神経保護作用機序ならびに認知機能障害改善作用の解析2013
- Author(s)
  高田和幸、北村佳久、金井美乃里、太田垣健人、富永　淳、松井香保里、弓倉　梓、芦原英司、下濱　俊
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] アルツハイマー病治療薬リバスチグミンの神経機能改善に関する解析2013
- Author(s)
  富永　淳、高田和幸、太田垣健人、松井香保里、池上倫代、弓倉　梓、北村佳久、下濱　俊、芦原英司
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2013
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] がん細胞選択的ドラッグデリバリー応用を目的としたエクソソームの脂質組成解析
- Author(s)
  戸田侑紀、高田和幸、中川由布子、川上光、藤岡周助、小林数也、服部恭尚、北村佳久、赤路健一、芦原英司
- Organizer
  第6回日本RNAi研究会
- Place of Presentation
  広島
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-25460109
[Presentation] Cancer cell tropism of glioblastoma-derived exosomes regulated by their lipid components.
- Author(s)
  Yuki Toda, Kazuyuki Takata, Yuko Nakagawa, Hikaru Kawakami, Shusuke Fujioka, Kazuya Kobayashi, Yasunao Hattori, Yoshihisa Kitamura, Kenichi Akaji, and Eishi Ashihara
- Organizer
  FEBS EMBO 2014
- Place of Presentation
  Paris, France
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25460109

1. Nomura Yasuyuki (00034041)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. TOKUMITU Yukiko (60001046)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Takata Kazuyuki (10434664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. TOHDA Michihisa (20207525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KIKUCHI Tohru (40025680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Sobue Gen (20148315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Okuma Yasunobu (20127939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Tomobe Koji (80460286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Kaneko Masayuki (10322827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. Ishigaki Shinsuke (40378170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kawada Koichi (30581631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TOMIMORI Tuyoshi (30100506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKADA Fumihiko (40109517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SHIMOHAMA Shou (60235687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 村山俊彦 (90174317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 上田亨 (00001032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 肱岡雅宣 (50780061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
19. TAKADA TESTUYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 香月博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 戸田侑紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 本望修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 松村晃寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 西村周泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 芦原英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitamura Yoshihisa 北村 佳久

KITAMURA Yoshihisa 北村 佳久

北村 佳久 キタムラ ヨシヒサ

Research Projects

Research Products

Co-Researchers

酸化ストレスセンサーDJ-1をターゲットとした脳神経変性疾患の薬理学的創薬研究Principal Investigator

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Pharmacological study of stress sensor DJ-1 on neurodegenerative disorder synucleinopathyPrincipal Investigator

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Review Section

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Developmental drug study targeting PARK7/DJ-1, a causetive gene of familial Parkinson's diseasePrincipal Investigator

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Review Section

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Study of oxydative stress sensor DJ-1 for therapeutic target of neurodegenerative diseasesPrincipal Investigator

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Involvement of novel ubiquitin ligases in the pathogenic mechanism of Alzheimer's disease and drug discovery for fundamental therapeutic agent

Principal Investigator

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Transplantation of bone marrow-derived microglia-like cells for the new cell therapy against Alzheimer's disease

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Glial Cell Therapy Using Neuroprotective effects of GliaPrincipal Investigator

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The Study of Cell Polarity, Movement and Unfolded Protein Phagocytosis in Brain Glial CellsPrincipal Investigator

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Neureu-glia interaction in Alzheimer's disease

Principal Investigator

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The Study of Neuroprotection and Regeneration on Neurodegenerative Flatworm model using inverteverate PlanarianPrincipal Investigator

Principal Investigator

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脳障害時におけるミクログリアおよびアストロサイトの機能変化の解析Principal Investigator

Principal Investigator

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脳傷害時におけるグリア細胞のニューロン機能増悪作用Principal Investigator

Principal Investigator

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Research Institution

一酸化窒素合成酵素によるシナプス可塑性およびニューロン死調節機構の神経化学的研究Principal Investigator

Principal Investigator

Kitamura Yoshihisa 北村佳久

KITAMURA Yoshihisa 北村佳久

北村佳久キタムラヨシヒサ

[Book] Development of cell therapeutic strategies for Alzheimer’s disease using animal models. In: Animal Models in Human Disease: Applications, Outcomes and Controversies　（Ed. S.A. Murray)2013