DOI Takahiro 土井貴裕

… Alternative Names

土井貴裕ドイタカヒロ

DOI Satoru 土井了

土井了ドイサトル

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Researcher Number	60227684
External Links
Affiliation (based on the past Project Information) *help	2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2015: 独立行政法人理化学研究所, 生体情報統合技術開発チーム, 研究員 2014: 独立行政法人理化学研究所, その他部局等, 研究員 2013: 独立行政法人理化学研究所, バイオリソースセンター, 開発研究員 2012: 独立行政法人理化学研究所, 生体情報総合技術開発チーム, サブチームリーダー … More 2009 – 2012: The Institute of Physical and Chemical Research, 生体情報統合技術開発チーム, サブチームリーダー 2004: 独立行政法人理化学研究所, 生体情報総合技術開発チーム, サブチームリーダー 1995 – 1997: 愛知県がんセンター, 免疫学部, 主任研究員 1993: 愛知県がんセンター, 免疫学部, 研究員 1990 – 1991: 東海大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Hematology / Biological Sciences Except Principal Investigator Immunology / Orthopaedic surgery / Hematology
Keywords	Principal Investigator NF-kB / マクロファージ / RelA / 骨芽細胞 / 破骨細胞 / カップリング / 骨粗鬆症 / リンパ球 / 造血機構 / Apopotsis … More / Maturation arrest / Macrophage / Lymphocyte / Apoptosis / Macrophages Maturation / phocytes / Lym / Hematopoiesis / c-Rel / Brca1 / 遺伝子発現プロファイリング / TNF耐性 / TNF / RelAサブユニット … More Except Principal Investigator 遺伝子導入マウス / マウスTL抗原 / 骨芽細胞 / マクロファージ / NF-kB / 造血幹細胞ニッチ / 骨代謝 / 体細胞突然変異 / 個体発癌 / cーHaーras / トランスジェニックマウス / Antigen / Transgenic mouse / alphabeta T cells / Positive selection / gammadelta T cells / Nonclassical MHC class I moleculesceramic coating / Mouse TL molecule / Immune system / 遺伝子欠失マウス / TCR / 抗原ペプチド / 非古典的MHCクラスI抗原 / γδT細胞 / 抗原分子 / αβT細胞 / 胸腺内選択 / γδT待望 / 非古典的MHCクラスI分子 / マウスTL / 生体防御 / オステオマック / 炎症性サイトカイン / 放射線 / 炎症 / 造血幹細胞移植 / 破骨細胞 / 造血幹細胞 / 転写因子 / 血球分化 / プロスタグランジンE2 / 骨髄マクロファージ / 免疫 / マウスレトロポゾン / リンパ腫 / 分化抑制 / 細胞分化 / Delta / Notch / 遺伝的多型 / T細胞リセプター / 細胞傷害性T細胞 / 抗原提示 / MHCクラスI抗原 / c-myc / Notch-1 / T細胞 / 白血病 / MHCクラスI分子 / アザチロシン / ジメチルベンズアントラセン(DMBA) / メチルニトロソウレア(MNU) / オンコジ-ン / 血管肉腫 / メチルニトロソウレア / 化学発癌 / 乳頭腫 Less

The dysfunction of macrophages/osteoclast precursors in bone metabolism after transplantation with RelA-deficient HSC.
- Principal Investigator
  
  Mise-Omata Setsuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
  Institute of Physical and Chemical Research
骨粗鬆症を発症するＲｅｌＡ欠損キメラマウスを用いた骨リモデリングの分子機構解明Principal Investigator
- Principal Investigator
  
  土井貴裕
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The Institute of Physical and Chemical Research
Role of NF-kB RelA in homeostasis of bone and hematopoietic niche
- Principal Investigator
  
  MISE Setsuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The Institute of Physical and Chemical Research
Elucidation of immune regulation mechanisms by NF-kB for development of lymphocytes and macrophages.Principal Investigator
- Principal Investigator
  
  DOI Takahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The Institute of Physical and Chemical Research
腫瘍壊死因子(TNF)、転写因子NFκB経路によるがん化防御機構の解析Principal Investigator
- Principal Investigator
  
  土井貴裕
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
免疫系細胞の正常分化ならびに癌化におけるNotch情報伝達系の役割
- Principal Investigator
  
  小幡裕一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
IMMUNE FUNCTION OF NONCLASSICAL MHC CLASS I MOLECULE
- Principal Investigator
  
  OBATA Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Aichi Cancer Center
TL抗原遺伝子とT細胞分化異常、白血病発生
- Principal Investigator
  
  OBATA Yuichi
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Aichi Cancer Center Research Institute
非典型的MHCクラスI抗原の機能
- Principal Investigator
  
  小幡裕一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
導入オンコジ-ンの体細胞突然変異誘発による個体発癌の研究
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokai University
導入オンコジ-ンの体細胞突然変異によって起こる個体発癌の研究
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokai University

All 2015 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] Biology in Stem Cell Niche.2015
- Author(s)
  Mise-Omata, S., Doi, TS, Aoki K., Obata Y.
- Total Pages
  14
- Publisher
  Springer Humana Press
- Data Source
  KAKENHI-PROJECT-25462392
[Journal Article] NF-kB inducing kinase(NIK) negatively regulates bone formation in vivo and in vitro2011
- Author(s)
  E. Jimi, T. Doi, et al
- Journal Title
  
  Endocrinology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation.2011
- Author(s)
  土井貴裕、丸山利正
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 25 Pages: 1058-1067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Interleukin 11 links oxidative stress and compensatory proliferation2011
- Author(s)
  H. Nakano, T. Doi, et al
- Journal Title
  
  Science Signalin
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Hepatocyte-Specific c-Flip-deficient mice uncover a causal link between ROS and STAT3 via IL-ll2011
- Author(s)
  土井貴裕、中野裕康
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Hepatocyte-Specific c-Flip-deficient mice uncover a causal link between ROS and STAT3 via IL-112010
- Author(s)
  H. Nakano, T. Doi, et al
- Journal Title
  
  Journal of Clinical Investigation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation2010
- Author(s)
  土井貴裕、丸山利正
- Journal Title
  
  Journal of Bone and Mineral Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclasogenesis.2010
- Author(s)
  土井貴裕、青木和広
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 25 Pages: 809-818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] The pivotal role of the alternative NF-kB pathway in maintenance of basal bone homeostasis and osteoclasogenesis2010
- Author(s)
  E. Jimi, T. Doi, et al
- Journal Title
  
  Journal of Bone and Mineral Research
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation2010
- Author(s)
  E. Jimi, T. Doi, et al
- Journal Title
  
  Journal of Bone and Mineral Research
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] The NF-kB RelA subunit confers resistance to Leishmania major by inducing NOS2 and Fas expression but not Th1 differentiation2009
- Author(s)
  S. Mise, T. Doi, et al
- Journal Title
  
  Journal of Immunology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] TNF ・represses BMP signaling by interfering with the DNA binding of SMADS through the activation of NF-・B2009
- Author(s)
  土井貴裕、山崎雅人
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages: 35987-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] The NF-kB RelA subunit confers resistance to Leishmania major by inducing NOS2 and Fas expression but not Th1 differentiation2009
- Author(s)
  三瀬節子、土井貴裕
- Journal Title
  
  Journal of Immunology 182
  
  Pages: 4910-4916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Journal Article] TNFa represses BMP signaling by interfering with the DNA binding of SMADS through the activation of NF-kB2009
- Author(s)
  E. Jimi, T. Doi, et al
- Journal Title
  
  Journal of Biological Chemistry
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] NF-kappaB, rela-deficient bone marrow macrophages fail to support bone formation and maintain HSC niche after lethal irradiation and HSC tranplantation.2013
- Author(s)
  Setsuko Mise－Omata, Neil Alles, Taro Fukazawa, Kazuhiro Aoki, Keiichi Ohya, Eijiro Jimi, Yuichi Obata, Takahiro Doi
- Organizer
  The joint international meeting of the 78th meeting of the japanese society of interferon and cytokine research and The 21st international symposium on Molecular cell biology of macrophages 2013
- Place of Presentation
  東京　日本
- Data Source
  KAKENHI-PROJECT-25462392
[Presentation] NF-kaｐpaB rela-deficient macrophages fail to support bone formation and maintain the microenvironment for hematopoiesis after X-ray irradiation and HSC transplantation.2013
- Author(s)
  Setsuko Mise-Omata,Taro Fukazawa, Yuichi Obata, Takahiro Doi
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25462392
[Presentation] NF-κB, rela-deficient bone marrow macrophages fail to support bone formation and maintain HSC niche after lethal irradiation and HSC transplantation2013
- Author(s)
  Setsuko Mise-Omata, Neil Alles, Taro Fukazawa, Kazuhiro Aoki, Keiichi Ohya, Eijiro Jimi, Yuichi Obata, and Takahiro Doi
- Organizer
  JSICR-MMCB 2013
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22591073
[Presentation] rela-deficient osteal tissue macrophages (osteomac) are not able to support bone formation, resulting in impairment of microenvironment for hematopoiesis2012
- Author(s)
  Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata and Takahiro Doi
- Organizer
  日本免疫学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22591073
[Presentation] Fukazawa, Yuichi Obata, and Takahiro Doi. NF-κB rela-deficient hematopoietic cells developed osteoporosis and poor activity of hematopoietic stem cells2011
- Author(s)
  Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata, and Takahiro Doi
- Organizer
  日本免疫学会総会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-22591073
[Presentation] RelA/c-Rel double knock out cells show distinct cell death phenotypes from RelA or c-Rel single knockout cells2011
- Author(s)
  土井貴裕
- Organizer
  第34階日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] NF-kB/RelA subunit plays the critical roles on erythropoiesis2011
- Author(s)
  土井貴裕、三瀬節子
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] NF-kB/RelA positively functions on transcriptional activation of Foxp3 with TGF-b signaling2010
- Author(s)
  土井貴裕、三瀬節子
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸市
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] NFkB/RelA positively functions on transcriptional activation of Foxp3 with TGF-beta signaling.2010
- Author(s)
  土井貴裕
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] Deficiency of NF-κB/RelA molecule in hematopoietic cells impairs lymphocyte development and bone metabolism: a possibility on a damage of hematopoietic niche2010
- Author(s)
  Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata and Takahiro Doi
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-22591073
[Presentation] NF-kB/RelA subunit is the essential regulatory factor for Foxp3.2010
- Author(s)
  土井貴裕
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] Deficiency of NF-kB/RelA subunit and Tumor necrosis factor(TNF)both causes abnormal hematopoiesis2009
- Author(s)
  土井貴裕
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] Deficiency of NF-kB/RelA subunit and tumor necrosis factor(TNF) both cause abnormal hamatopoiesis.2009
- Author(s)
  土井貴裕、三瀬節子
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21591254
[Presentation] NFkB/RelA subunit plays the critical role on autoimmunity2009
- Author(s)
  土井貴裕
- Organizer
  日本免疫学会
- Place of Presentation
  グランキューブ大阪(大阪)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21591254

1. MISE Setsuko (00269052)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. OBATA Yuichi (30177290)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TAKAHASHI Toshitada (00124529)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TSUJIMURA Kunio (10227407)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 勝木元也 (20051732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 木村穣 (10146706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安藤潔 (70176014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 権藤洋一 (40225678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 田口修 (00142167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 深澤太郎 (10565774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

DOI Takahiro 土井 貴裕

土井 貴裕 ドイ タカヒロ

DOI Satoru 土井 了

土井 了 ドイ サトル

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骨粗鬆症を発症するＲｅｌＡ欠損キメラマウスを用いた骨リモデリングの分子機構解明Principal Investigator

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Elucidation of immune regulation mechanisms by NF-kB for development of lymphocytes and macrophages.Principal Investigator

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腫瘍壊死因子(TNF)、転写因子NFκB経路によるがん化防御機構の解析Principal Investigator

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[Book] Biology in Stem Cell Niche.2015

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[Journal Article] NF-kB inducing kinase(NIK) negatively regulates bone formation in vivo and in vitro2011

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Data Source

[Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation.2011

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Journal Title

Data Source

[Journal Article] Interleukin 11 links oxidative stress and compensatory proliferation2011

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Data Source

[Journal Article] Hepatocyte-Specific c-Flip-deficient mice uncover a causal link between ROS and STAT3 via IL-ll2011

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Journal Title

DOI Takahiro 土井貴裕

土井貴裕ドイタカヒロ

DOI Satoru 土井了

土井了ドイサトル