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DOI Takahiro  土井 貴裕

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… Alternative Names

土井 貴裕  ドイ タカヒロ

DOI Satoru  土井 了

土井 了  ドイ サトル

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Researcher Number 60227684
External Links
Affiliation (based on the past Project Information) *help 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員
2015: 独立行政法人理化学研究所, 生体情報統合技術開発チーム, 研究員
2014: 独立行政法人理化学研究所, その他部局等, 研究員
2013: 独立行政法人理化学研究所, バイオリソースセンター, 開発研究員
2012: 独立行政法人理化学研究所, 生体情報総合技術開発チーム, サブチームリーダー … More
2009 – 2012: The Institute of Physical and Chemical Research, 生体情報統合技術開発チーム, サブチームリーダー
2004: 独立行政法人理化学研究所, 生体情報総合技術開発チーム, サブチームリーダー
1995 – 1997: 愛知県がんセンター, 免疫学部, 主任研究員
1993: 愛知県がんセンター, 免疫学部, 研究員
1990 – 1991: 東海大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Orthopaedic surgery / Hematology / Biological Sciences
Except Principal Investigator
Immunology / Orthopaedic surgery / Hematology
Keywords
Principal Investigator
NF-kB / マクロファージ / RelA / 骨芽細胞 / 破骨細胞 / カップリング / 骨粗鬆症 / リンパ球 / 造血機構 / Apopotsis … More / Maturation arrest / Macrophage / Lymphocyte / Apoptosis / Macrophages Maturation / phocytes / Lym / Hematopoiesis / c-Rel / Brca1 / 遺伝子発現プロファイリング / TNF耐性 / TNF / RelAサブユニット … More
Except Principal Investigator
遺伝子導入マウス / マウスTL抗原 / 骨芽細胞 / マクロファージ / NF-kB / 造血幹細胞ニッチ / 骨代謝 / 体細胞突然変異 / 個体発癌 / cーHaーras / トランスジェニックマウス / Antigen / Transgenic mouse / alphabeta T cells / Positive selection / gammadelta T cells / Nonclassical MHC class I moleculesceramic coating / Mouse TL molecule / Immune system / 遺伝子欠失マウス / TCR / 抗原ペプチド / 非古典的MHCクラスI抗原 / γδT細胞 / 抗原分子 / αβT細胞 / 胸腺内選択 / γδT待望 / 非古典的MHCクラスI分子 / マウスTL / 生体防御 / オステオマック / 炎症性サイトカイン / 放射線 / 炎症 / 造血幹細胞移植 / 破骨細胞 / 造血幹細胞 / 転写因子 / 血球分化 / プロスタグランジンE2 / 骨髄マクロファージ / 免疫 / マウスレトロポゾン / リンパ腫 / 分化抑制 / 細胞分化 / Delta / Notch / 遺伝的多型 / T細胞リセプター / 細胞傷害性T細胞 / 抗原提示 / MHCクラスI抗原 / c-myc / Notch-1 / T細胞 / 白血病 / MHCクラスI分子 / アザチロシン / ジメチルベンズアントラセン(DMBA) / メチルニトロソウレア(MNU) / オンコジ-ン / 血管肉腫 / メチルニトロソウレア / 化学発癌 / 乳頭腫 Less
  • Research Projects

    (11 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (10 People)
  •  The dysfunction of macrophages/osteoclast precursors in bone metabolism after transplantation with RelA-deficient HSC.

    • Principal Investigator
      Mise-Omata Setsuko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokyo Medical and Dental University
      Institute of Physical and Chemical Research
  •  骨粗鬆症を発症するRelA欠損キメラマウスを用いた骨リモデリングの分子機構解明Principal Investigator

    • Principal Investigator
      土井 貴裕
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Role of NF-kB RelA in homeostasis of bone and hematopoietic niche

    • Principal Investigator
      MISE Setsuko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Elucidation of immune regulation mechanisms by NF-kB for development of lymphocytes and macrophages.Principal Investigator

    • Principal Investigator
      DOI Takahiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The Institute of Physical and Chemical Research
  •  腫瘍壊死因子(TNF)、転写因子NFκB経路によるがん化防御機構の解析Principal Investigator

    • Principal Investigator
      土井 貴裕
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  免疫系細胞の正常分化ならびに癌化におけるNotch情報伝達系の役割

    • Principal Investigator
      小幡 裕一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Aichi Cancer Center Research Institute
  •  IMMUNE FUNCTION OF NONCLASSICAL MHC CLASS I MOLECULE

    • Principal Investigator
      OBATA Yuichi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Aichi Cancer Center
  •  TL抗原遺伝子とT細胞分化異常、白血病発生

    • Principal Investigator
      OBATA Yuichi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Aichi Cancer Center Research Institute
  •  非典型的MHCクラスI抗原の機能

    • Principal Investigator
      小幡 裕一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Aichi Cancer Center Research Institute
  •  導入オンコジ-ンの体細胞突然変異誘発による個体発癌の研究

    • Principal Investigator
      勝木 元也
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University
  •  導入オンコジ-ンの体細胞突然変異によって起こる個体発癌の研究

    • Principal Investigator
      勝木 元也
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokai University

All 2015 2013 2012 2011 2010 2009

All Journal Article Presentation Book

  • [Book] Biology in Stem Cell Niche.2015

    • Author(s)
      Mise-Omata, S., Doi, TS, Aoki K., Obata Y.
    • Total Pages
      14
    • Publisher
      Springer Humana Press
    • Data Source
      KAKENHI-PROJECT-25462392
  • [Journal Article] NF-kB inducing kinase(NIK) negatively regulates bone formation in vivo and in vitro2011

    • Author(s)
      E. Jimi, T. Doi, et al
    • Journal Title

      Endocrinology

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation.2011

    • Author(s)
      土井貴裕、丸山利正
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 25 Pages: 1058-1067

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Interleukin 11 links oxidative stress and compensatory proliferation2011

    • Author(s)
      H. Nakano, T. Doi, et al
    • Journal Title

      Science Signalin

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Hepatocyte-Specific c-Flip-deficient mice uncover a causal link between ROS and STAT3 via IL-ll2011

    • Author(s)
      土井貴裕、中野裕康
    • Journal Title

      Journal of Clinical Investigation

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Hepatocyte-Specific c-Flip-deficient mice uncover a causal link between ROS and STAT3 via IL-112010

    • Author(s)
      H. Nakano, T. Doi, et al
    • Journal Title

      Journal of Clinical Investigation

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation2010

    • Author(s)
      土井貴裕、丸山利正
    • Journal Title

      Journal of Bone and Mineral Research (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclasogenesis.2010

    • Author(s)
      土井貴裕、青木和広
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 25 Pages: 809-818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] The pivotal role of the alternative NF-kB pathway in maintenance of basal bone homeostasis and osteoclasogenesis2010

    • Author(s)
      E. Jimi, T. Doi, et al
    • Journal Title

      Journal of Bone and Mineral Research

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] Processing of the NF-kB2 precursor, p100, to p52 is critical for RANKL-induced osteoclast differentiation2010

    • Author(s)
      E. Jimi, T. Doi, et al
    • Journal Title

      Journal of Bone and Mineral Research

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] The NF-kB RelA subunit confers resistance to Leishmania major by inducing NOS2 and Fas expression but not Th1 differentiation2009

    • Author(s)
      S. Mise, T. Doi, et al
    • Journal Title

      Journal of Immunology

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] TNF ・represses BMP signaling by interfering with the DNA binding of SMADS through the activation of NF-・B2009

    • Author(s)
      土井貴裕、山崎雅人
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 35987-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] The NF-kB RelA subunit confers resistance to Leishmania major by inducing NOS2 and Fas expression but not Th1 differentiation2009

    • Author(s)
      三瀬節子、土井貴裕
    • Journal Title

      Journal of Immunology 182

      Pages: 4910-4916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Journal Article] TNFa represses BMP signaling by interfering with the DNA binding of SMADS through the activation of NF-kB2009

    • Author(s)
      E. Jimi, T. Doi, et al
    • Journal Title

      Journal of Biological Chemistry

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] NF-kappaB, rela-deficient bone marrow macrophages fail to support bone formation and maintain HSC niche after lethal irradiation and HSC tranplantation.2013

    • Author(s)
      Setsuko Mise-Omata, Neil Alles, Taro Fukazawa, Kazuhiro Aoki, Keiichi Ohya, Eijiro Jimi, Yuichi Obata, Takahiro Doi
    • Organizer
      The joint international meeting of the 78th meeting of the japanese society of interferon and cytokine research and The 21st international symposium on Molecular cell biology of macrophages 2013
    • Place of Presentation
      東京 日本
    • Data Source
      KAKENHI-PROJECT-25462392
  • [Presentation] NF-kappaB rela-deficient macrophages fail to support bone formation and maintain the microenvironment for hematopoiesis after X-ray irradiation and HSC transplantation.2013

    • Author(s)
      Setsuko Mise-Omata,Taro Fukazawa, Yuichi Obata, Takahiro Doi
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-25462392
  • [Presentation] NF-κB, rela-deficient bone marrow macrophages fail to support bone formation and maintain HSC niche after lethal irradiation and HSC transplantation2013

    • Author(s)
      Setsuko Mise-Omata, Neil Alles, Taro Fukazawa, Kazuhiro Aoki, Keiichi Ohya, Eijiro Jimi, Yuichi Obata, and Takahiro Doi
    • Organizer
      JSICR-MMCB 2013
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22591073
  • [Presentation] rela-deficient osteal tissue macrophages (osteomac) are not able to support bone formation, resulting in impairment of microenvironment for hematopoiesis2012

    • Author(s)
      Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata and Takahiro Doi
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22591073
  • [Presentation] Fukazawa, Yuichi Obata, and Takahiro Doi. NF-κB rela-deficient hematopoietic cells developed osteoporosis and poor activity of hematopoietic stem cells2011

    • Author(s)
      Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata, and Takahiro Doi
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-22591073
  • [Presentation] RelA/c-Rel double knock out cells show distinct cell death phenotypes from RelA or c-Rel single knockout cells2011

    • Author(s)
      土井貴裕
    • Organizer
      第34階日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] NF-kB/RelA subunit plays the critical roles on erythropoiesis2011

    • Author(s)
      土井貴裕、三瀬節子
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] NF-kB/RelA positively functions on transcriptional activation of Foxp3 with TGF-b signaling2010

    • Author(s)
      土井貴裕、三瀬節子
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] NFkB/RelA positively functions on transcriptional activation of Foxp3 with TGF-beta signaling.2010

    • Author(s)
      土井貴裕
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] Deficiency of NF-κB/RelA molecule in hematopoietic cells impairs lymphocyte development and bone metabolism: a possibility on a damage of hematopoietic niche2010

    • Author(s)
      Setsuko Mise-Omata, Taro Fukazawa, Yuichi Obata and Takahiro Doi
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Data Source
      KAKENHI-PROJECT-22591073
  • [Presentation] NF-kB/RelA subunit is the essential regulatory factor for Foxp3.2010

    • Author(s)
      土井貴裕
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] Deficiency of NF-kB/RelA subunit and Tumor necrosis factor(TNF)both causes abnormal hematopoiesis2009

    • Author(s)
      土井貴裕
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] Deficiency of NF-kB/RelA subunit and tumor necrosis factor(TNF) both cause abnormal hamatopoiesis.2009

    • Author(s)
      土井貴裕、三瀬節子
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21591254
  • [Presentation] NFkB/RelA subunit plays the critical role on autoimmunity2009

    • Author(s)
      土井貴裕
    • Organizer
      日本免疫学会
    • Place of Presentation
      グランキューブ大阪(大阪)
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-21591254
  • 1.  MISE Setsuko (00269052)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 2.  OBATA Yuichi (30177290)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TAKAHASHI Toshitada (00124529)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  TSUJIMURA Kunio (10227407)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  勝木 元也 (20051732)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  木村 穣 (10146706)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  安藤 潔 (70176014)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  権藤 洋一 (40225678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  田口 修 (00142167)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  深澤 太郎 (10565774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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