Yamaotsu Noriyuki 山乙教之

… Alternative Names

YAMAOTSU Noriyuki 山乙教之

山乙教育ヤマオツノリユキ

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Researcher Number	60230322
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2017: 北里大学, 薬学部, 講師 2011 – 2012: 北里大学, 薬学部, 講師 2010 – 2011: 北里大学, 薬学部, 助教 2007 – 2008: Kitasato University, School of Pharmacy, Assistant Professor 2006: 北里大学, 薬学部, 助手 … More 1998 – 2004: 北里大学, 薬学部, 助手 1995 – 1996: 北里大学, 薬学部, 助手 1991 – 1993: 北里大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / 医薬分子機能学 Except Principal Investigator Physical pharmacy / Physical pharmacy / Drug development chemistry
Keywords	Principal Investigator ドッキング / 複合体 / 相互作用 / 水素結合 / 蛋白質 / 酵素 / 結晶水 / リガンド / 分子動力学法 / 薬物結合 … More / イブプロフェン / ワルファリン / 血漿タンパク結合 / ヒト血清アルブミン / タンパク質-薬物複合体 / 結合様式 / 結合サイト … More Except Principal Investigator NMR / TRNOE / ドラッグデザイン / SUPERPOSE / Molecular Dynamics / 結合配座 / 阻害剤 / 分子動力学法 / Ligand-Based Drug Design / Site II / Site I / 分子重ね合わせ法 / サイトII / サイトI / ヒト血清アルブミン / CAMDAS / Binding Conformation / Human Serum Albumin / 結合自由エネルギー / 分子動力学 / ドッキング計算 / キチナーゼ / 分子動力学計算 / カルモデュリン / バーチャルスクリーニング / 3D-Pharmacophore / フラグメントマッピング / イン・シリコ / FBDD / SBDD / フラグメントマッピング法 / in silico 創薬手法 / Pharmacokinetics / 3D-pharmacophore / Transporter / 3D-QSAR / in silico screening / 薬物動態 / 三次元ファーマコフォア / トランスポータ / 三次元定量的構造活性相関 / ligand docking / homology modeling / HERG / OT prolongation / binding conformation / molecular superpose / conformational search / QT延長作用 / 分子重ね合わせ / 配座解析 / リガンドドッキング / ホモロジーモデリング / QT延長 / HERGチャネル / Docking / 分子動力額計算 / ドッキング / Protein Binding / HAS / タンパク結合 / 分子動力学計算法 / Conformation Analysis / 血清アルブミン / 立体配座解析 / Biodegradability / Mutagenicity / Carcinogenicity / Human acute toxicity / Aquatic toxicity / Toxicity prediction / Quantitative structure-toxicity relationship / 構造毒性相関 / 有機化学物質 / 安全性 / 適応最小二乗法 / ファジィ集合 / ファジィ理論 / 生分解性 / 変異原性 / 発がん性 / 急性毒性 / 疎水性 / 有害性予測 / パターン認識 / 定量的構造活性相関 / 抗ガン剤開発 / 蛋白-蛋白相互作用 / イン・シリコ創薬 / 医薬分子設計 / タンパク質間相互作用 / 抗癌剤 / 蛋白質-蛋白質相互作用 / イン・シリコ分子設計 / 抗ガン剤 / 抗真菌薬 / 喘息治療薬 / 複合体 / W-7 / TFP / 3次元構造解析 / 溶液構造 / 生体高分子 / 計算機実験 / 相互作用エネルギー解析 / カルモデュリン-メリチン複合体 / コンピュータグラフィックス / コンピュータシミュレーション / 標的蛋白質調節機構 / 標的蛋白質認識機構 Less

Development of in silico fragment-based drug design method for rational drug discovery
- Principal Investigator
  
  Hirono Shuichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Development of a new docking method using the hypothetical hydratedligand which take account of bridging water moleculesPrincipal Investigator
- Principal Investigator
  
  YAMAOTSU Noriyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Optimization of chitinase inhibitor with macrolide scaffold based on in silico drug discovery techniques
- Principal Investigator
  
  GOUDA Hiroaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
In silico drug design study targeting CRK-C3G interaction for future development of anticarcinogenic agent
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kitasato University
Computer-aided rational molecular design of novel chitinase inhibitor
- Principal Investigator
  
  GOUDA Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
3D-pharmacophore analyses of transporter ligands for drug discovery studies in consideration of pharmacokinetics
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Three-dimensional structure-activity relationships of drugs induced cardiovascular side effects (prolongation in the QT interval)
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  School of Pharmaceutical sciences, Kitasato University
立体構造既知のタンパク質に対する薬物の結合サイト及び結合様式の計算化学的解析Principal Investigator
- Principal Investigator
  
  山乙教之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kitasato University
Determination of binding conformations of drugs to HAS and modeling of drug-HAS complex
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーションによるカルモデュリン-阻害剤複合体の溶液構造解析
- Principal Investigator
  
  広野修一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato University
Analysis of binding conformations of drugs to human serum albumin (site I and site II) by NMR measurements and computational calculations
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Determination of Binding Conformation of Drugs to Human Serum Albumin by Molecular Dynamics Calculations and Transferred Nuclear Overhauser Effect Measurements
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーシヨンによる生体高分子の新しい立体配座解析法の研究
- Principal Investigator
  
  広野修一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
分子動力学シミュレーションによるカルモデュリンの標的蛋白質認識・調節機構の研究
- Principal Investigator
  
  HIRONO Shuichi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University
Prediction of Toxicity of Organic Chemicals Using Fuzzy Adaptive Least-Squares
- Principal Investigator
  
  MORIGUCHI Ikuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kitasato University

All 2017 2015 2012 2011 2010 2009 2008 2007 2004 2003 Other

All Journal Article Presentation

[Journal Article] Multi-step virtual screening to develop selective DYRK1A inhibitors2017
- Author(s)
  Tomoko Koyama, Noriyuki Yamaotsu, Izumi Nakagome, Shin-ichiro Ozawa, Tomoki Yoshida, Daichi Hayakawa, Shuichi Hirono
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 72 Pages: 229-239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07899
[Journal Article] Essential Structure of Opioid κ Receptor Agonist Nalfurafine for Binding to κ Receptor 1: Synthesis of Decahydroisoquinoline Derivatives and Their Pharmacologies2012
- Author(s)
  Nagase H、Imaide S、Yamada T、Hirayama S、 Nemoto T、 Yamaotsu N、 Hirono S、 Fujii H
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Issue: 8 Pages: 945-948
- DOI
  10.1248/cpb.c12-00336
- NAID
  130001852522
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-23590133
[Journal Article] Quantitative Structure-Activity Relationship (QSAR) Analysis to Predict Drug-Drug Interactions of ABC Transporter ABCG22012
- Author(s)
  Ishikawa T、 Hirano H、Saito H、Sano K、Ikegami Y 、 Yamaotsu N 、 Hirono S
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry
  
  Volume: 12(6) Issue: 6 Pages: 505-514
- DOI
  10.2174/138955712800493825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042
[Journal Article] AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy2012
- Author(s)
  Ohashi Y, Iijima H, Yamaotsu N, Yamazaki K, Sato S, Okamura M, Sugimoto K, Dan S, Hirono S, Yamori T
- Journal Title
  
  J Biol Chem
  
  Volume: 287(6) Issue: 6 Pages: 3885-3897
- DOI
  10.1074/jbc.m111.316125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22700929, KAKENHI-PROJECT-221S0001
[Journal Article] Brazilian propolis-derived components inhibit TNF- a -mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes2011
- Author(s)
  Ikeda R、Yanagisawa M、Takahashi N、Kawada T 、 Kumazawa S 、 Yamaotsu N 、Nakagome I 、 Hirono S 、 Tsuda T
- Journal Title
  
  Biochimica et Biophysica Acta - General Subjects
  
  Volume: 1810(7) Issue: 7 Pages: 695-703
- DOI
  10.1016/j.bbagen.2011.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-23580180, KAKENHI-PROJECT-23580187
[Journal Article] Identification of the threedimensional pharmacophore ofκ-opioid receptor agonists2010
- Author(s)
  Noriyuki Yamaotsu, Hideaki Fujii, Hiroshi Nagase, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 4446-4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.2010
- Author(s)
  Noriyuki Yamaotsu, Hideaki Fujii, Hiroshi Nagase, Shuichi Hirono
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 4446-4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Gouda H, Sunazuka T, Hirose T, Iguchi K, Yamaotsu N, Sugawara A, Noguchi Y, Saito Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 5835-5844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin2010
- Author(s)
  Hiroaki Gouda, Toshiaki Sunazuka, Tomoyasu Hirose, Kanami Iguchi, Noriyuki Yamaotsu, Akihiro Sugawara, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Takeshi Watanabe, Kazuro Shiomi, Satoshi Omura, Shuichi Hirono
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18(16) Issue: 16 Pages: 5835-5844
- DOI
  10.1016/j.bmc.2010.06.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590046, KAKENHI-PROJECT-21590122, KAKENHI-PROJECT-22590042, KAKENHI-PROJECT-22790017, KAKENHI-PROJECT-22890175
[Journal Article] Drug design and synthesis of a novelκopioid receptor agonist with an oxabicyclo[2.2.2] octane skeleton and its pharmacology2010
- Author(s)
  Hiroshi Nagase, Akio Watanabe, Toru Nemoto, Noriyuki Yamaotsu, Kohei Hayashida, Mayumi Nakajima, Ko Hasebe, Kaoru Nakao, Hidenori Mochizuki, Shuichi Hirono, Hideaki Fujii
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 20 Pages: 121-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590122
[Journal Article] Identification of the three-dimensional pharmacophore of κ-opioid receptor agonists2010
- Author(s)
  Noriyuki Yamaotsu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18 Pages: 4446-4452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042
[Journal Article] Identification of the three-dimensional pharmacophore of k-opioid receptor agonists2010
- Author(s)
  Yamaotsu N、Fujii H、Nagase H、Hirono S
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 18(12) Issue: 12 Pages: 4446-4452
- DOI
  10.1016/j.bmc.2010.04.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590042
[Journal Article] Structure-Based CoMFA As a Predictive Model-CYP2C9 Inhibitors As a Test Case2009
- Author(s)
  Yasuo K, Yamaotsu N, Gouda H, Tsujishita H, Hirono S
- Journal Title
  
  J. Chem. Inf. Model 49(4)
  
  Pages: 853-864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] In silico multi-filter screening approaches for developing novel β -secretase inhibitors2008
- Author(s)
  Fujimoto T, Matsushita Y, Gouda H, Yamaotsu N, Hirono S
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18(9)
  
  Pages: 2771-2775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590043
[Journal Article] Studies of Binding Modes of (S)-Mephenytoin to Wild Types and Mutants of Cytochrome P450 2C19 and 2C9 using Homology Modeling and Computational Docking2004
- Author(s)
  Oda A, Yamaotsu N, Hirono S
- Journal Title
  
  Pharm.Res 21(12)
  
  Pages: 2270-2278
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Journal Article] Studies of Binding Modes of (S)-Mephenytoin to Wild Types and Mutants of Cytochrome P450 2C19 and 2C19 using Homology Modeling and Computational Docking2003
- Author(s)
  Oda A, Yamaotsu N, Hirono S
- Journal Title
  
  Pharm.Res 21(12)
  
  Pages: 2270-2278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590048
[Presentation] 筋萎縮治療薬の開発を目指したSMAD3 阻害剤SIS3 の結合様式の同定2017
- Author(s)
  中込泉，楠本彩瑛，飯島瑛里香，山乙教之，宮本健史，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] フラグメントマッピング法によるUSP7-HDM2 タンパク質間相互作用(PPI)阻害剤の探2017
- Author(s)
  三沢　憲佑, 小澤　新一郎, 吉田　智喜, 中込　泉, 山乙　教之, 広野　修一
- Organizer
  第３5 回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] アミノ酸残基マッピング法を用いたPPI 界面における相互作用スポット予測手法の開発2017
- Author(s)
  市村博信，山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] SBDD のためのin silico フラグメント・マッピング法の開発2017
- Author(s)
  山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] イン・シリコフラグメントマッピング法を用いた新規PAD4阻害剤の探索2017
- Author(s)
  片村百々奈、中込泉、山乙教之、広野修一
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] In silico フラグメントマッピング法を用いた新規PAD4 阻害剤の探索2017
- Author(s)
  片村百々奈，中込泉，山乙教之，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] In silico フラグメントマッピング法を用いたリガンド結合様式予測法の開発2017
- Author(s)
  杉山耀司，山乙教之，吉田智喜，広野修一
- Organizer
  第45 回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] 1.アミノ酸残基－サブサイトデータベースを用いた新規PPI界面予測手法の開発2017
- Author(s)
  市村博信、山乙教之、広野修一
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] Similarity analyses of ligand-binding subsites on proteins2015
- Author(s)
  Yamaotsu N., Hirono S.
- Organizer
  PacifiChem2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07899
[Presentation] 蛋白質の水分子結合モチーフ:架橋水と水和水2012
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会 2012 秋季年
- Place of Presentation
  山形大学(山形県)
- Year and Date
  2012-10-14
- Data Source
  KAKENHI-PROJECT-22590042
[Presentation] PPARγLBDと三環系PPARγパーシャルアゴニストの相互作用解析2012
- Author(s)
  中込泉, 豊岡尚樹, 峰平大輔, 竹田大輔, 加藤敦, 足立伊左雄, 松谷裕二, 川田耕司, 佐藤謙一, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] PPARγLBDと三環系PPARγパーシャルアゴニストの相互作用解析2012
- Author(s)
  中込泉, 豊岡尚樹, 峰平大輔, 竹田大輔, 加藤敦, 足立伊左雄, 松谷裕二, 川田耕司, 佐藤謙一, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] ヒトCYP3A4阻害剤の3次元定量的構造活性相関-Structure-based CoMFA-2012
- Author(s)
  半田耕一, 中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] ヒトCYP3A4阻害剤の3次元定量的構造活性相関-Structure-based CoMFA-2012
- Author(s)
  半田耕一, 中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] タンパク質と相互作用する分子フラグメント探索法の開発2011
- Author(s)
  山乙教之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590042
[Presentation] 津田孝範,熊澤茂則アディポネクチン発現低下を抑制するプロポリス成分化合物とPPARγLBDの相互作用解析2011
- Author(s)
  中込泉, 山乙教之, 合田浩明, 広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] タンパク質と相互作用する分子フラグメント探索法の開発2011
- Author(s)
  山乙教之、広野修一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] アディポネクチン発現低下を抑制するプロポリス成分化合物とPPARγLBDの相互作用解析2011
- Author(s)
  中込泉, 山乙教之, 合田浩明, 広野修一, 津田孝範, 熊澤茂則
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] ンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之, 中込泉, 合田浩明, 広野修一
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之, 中込泉, 合田浩明, 広野修一
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井商工会議所(福井県)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井商工会議所(福井県)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会2011秋季年会
- Place of Presentation
  福井商工会議所(福井県)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22590042
[Presentation] タンパク質と相互作用する分子フラグメントを同定するプログラムの開発2011
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会 2011 秋季年会
- Place of Presentation
  福井商工会議所(福井県)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22590042
[Presentation] タンパク質と相互作用する分子フラグメント探索法の開発2011
- Author(s)
  山乙教之
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡県
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590042
[Presentation] 分子重ね合わせ法を用いたLigand-Based Drug Design手法によるcongenericな化合物群の3D-QSARモデルの構築及びその検証2010
- Author(s)
  土井一生, 山乙教之, 合田浩明, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] In silico創薬技術に基づくD-aspartate oxidase-thiolactomycin複合体の構造解析2010
- Author(s)
  中込泉, 山乙教之, 合田浩明, 片根真澄, 本間浩, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] 分子重ね合わせ法を用いたLigand-Based Drug Design手法によるcongenericな化合物群の3D-QSARモデルの構築及びその検証2010
- Author(s)
  土井一生, 山乙教之, 合田浩明, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] The ligand-based drug design method effective for identifying the active conformations and 3-dimensional pharmacophores of congeneric compounds2010
- Author(s)
  Issei Doi, Noriyuki Yamaotsu, Hiroaki Gouch, Shuichi Hirono
- Organizer
  18^<th> Euro QSAR
- Place of Presentation
  Rhodes, Greece
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] In silico創薬技術に基づくD-aspartate oxidase-thiolactomycin複合体の構造解析2010
- Author(s)
  中込泉, 山乙教之, 合田浩明, 片根真澄, 本間浩, 広野修一
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21590046
[Presentation] 3D-QSAR MODELS FOR THE PPARS AGONISTS WITH DUE REGARD TO MEMBRANE TRANSPORT2009
- Author(s)
  S.Hirono, I.Nakagome, N.Yamaotsu, H.Gouda
- Organizer
  Frontiers in Medicinal Chemistry
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-21590122
[Presentation] SYBYL Zapプログラムを用いたMM/PBSA結合自由エネルギー計算によるドッキングポーズ選択の有効性2007
- Author(s)
  山乙教之、木村敏郎、広野修一
- Organizer
  第35回構造活性相関シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-18590037
[Presentation] 蛋白質の水分子結合モチーフ：架橋水と水和水
- Author(s)
  山乙教之
- Organizer
  日本コンピュータ化学会2012秋季年会
- Place of Presentation
  山形大学（山形県）
- Data Source
  KAKENHI-PROJECT-22590042

1. HIRONO Shuichi (30146328)

# of Collaborated Projects: 13 results

# of Collaborated Products: 36 results
2. NAKAGOME Izumi (30237242)

# of Collaborated Projects: 11 results

# of Collaborated Products: 16 results
3. GOUDA Hiroaki (60276160)

# of Collaborated Projects: 9 results

# of Collaborated Products: 17 results
4. MATSUSHITA Yasuo (40050653)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. MORIGUCHI Ikuo (90050343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 矢守隆夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaotsu Noriyuki 山乙 教之

YAMAOTSU Noriyuki 山乙 教之

山乙 教育 ヤマオツ ノリユキ

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Development of a new docking method using the hypothetical hydratedligand which take account of bridging water moleculesPrincipal Investigator

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立体構造既知のタンパク質に対する薬物の結合サイト及び結合様式の計算化学的解析Principal Investigator

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Yamaotsu Noriyuki 山乙教之

YAMAOTSU Noriyuki 山乙教之

山乙教育ヤマオツノリユキ