Takahashi Hiroki 高橋弘毅

… Alternative Names

TAKAHASHI Hiroki 高橋弘毅

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Researcher Number	60231396
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2005 – 2019: Sapporo Medical University, School of Medicine, Professor, 医学部, 教授 2000 – 2004: SCHOOL OF MEDICINE, SAPPORO MEDICAL UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 助教授 1999: 札幌医科大学, 医学部, 講師 1997: SAPPORO MEDICAL UNIVERSITY,SCHOOL OF MEDICINE,DEPARTMENT OF INTERNALMEDICINE ASSISTANT PROFESSOR, 医学部・内科学, 講師 1996 – 1997: 札幌医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / Medical systems / Biological Sciences
Keywords	Principal Investigator 間質性肺炎 / 肺サーファクタント / SP-A / ブレオマイシン / 肺胞マクロファージ / Toll-like receptor / トル様受容体 / 肺コレクチン / lipoprotein / Mycoplasma pneumoniae … More / peptidoglycan / Staphylococcus aureus / alveolar macrophage / CD14 / SP-D / PULMONARY SURFACTANT / 肺傷害 / 急性肺傷害 / 肺サーファクタントタンパク質A / 肺線維化 / 薬剤性肺障害 / 免疫学 / 内科 / surfactant protein A / interstitial pneumonia / TNF-α / 肺サーファクタント蛋白質 / Toll様受容体 / サーファクタント蛋白質-A / neutrophil / type II pneumocytes / lung fibrosis / interstitial lung injury / Candesartan / angiotensin receptor 1 / アンギオテンシンII / 線維化 / 肺胞II型上皮細胞 / candesartan / Angiotensin II receptor 1 / Renin-Angiotensin系 / 好中球 / II型上皮細胞 / 肺線維症 / 間質性肺傷害 / カンデサルタン / アンギオテンシン・レセプター / ALVEOLAR MACROPHAGE / IDIOPATHIC PULMONARY FIBROSIS / SEROLOGICAL DIAGNOSIS / RADIATION PNEUMONITIS / INTERSTITIAL PNEUMONIA / SURFACTANT PROTEIN D / SURFACTANT PROTEIN A / 血清診断 / 放射線肺炎 / サーファクタント蛋白質D / サーファクタント蛋白質A / 抗線維化 / 抗炎症 / アレルギー性気道炎症 / 急性肺障害 / ノックアウトマウス / TLR2 / 肺サーファクタント蛋白質A … More Except Principal Investigator SP-A / SP-D / MD-2 / Toll-like receptor / コレクチン / 肺サーファクタント / SP-C / 肺サーファクタント蛋白質 / Toll様受容体 / 肺コレクチン / 内科 / endotoxin / collectin / エンドトキシン / pulmonary surfactant / スカベンジャー受容体 / RT-PCR / CC-10 / EGFR / EGFR遺伝子変異 / 肺サーファクタントタンパク質 / レクチン / 糖鎖 / 肺がん / 変異型EGFR / 肺サーファクタント蛋白質D / サーファクタント蛋白質 / ピルフェニドン / ニンテダニブ / サーファクタント蛋白質A / 抗線維化薬 / 特発性肺線維症 / 肺炎球菌感染症 / 感染症 / 肺炎球菌 / pulmonary inflammation / TLR4 / 肺炎症 / トル様受容体 / computer aided diagnosis / virtual navigation / alveolus / bronchiole / lung / micro focused CT / virtual microscopic endoscopy / 肺末梢領域 / マイクロフォーカスコーンビームCT / 仮想現実 / 画像診断支援 / 探索診断 / 顕微鏡的仮想化内視鏡 / バーチャルリアリティ / 情報工学 / 医療福祉 / コンピュータ支援診断 / 仮想現実的顕微探索 / 肺胞 / 細気管支 / 肺 / マイクロフォーカスCT / 仮想化内視鏡 / phagocytic receptor / pulmonary surfactant proteins / CD14 / 非定型抗酸菌 / 貪食受容体 / zymosan / alveolar macrophage / mannose receptor / scavenger receptor A / ザイモザン / ペプチドグリカン / 自然免疫 / ザイモサン / 肺胞マクロファージ / マンノース受容体 / peripheral blood / adenocarcinoma cells / lung cancer / サイトケラチン / 免疫染色 / PCR / clara cell 10kd protein / サーファクタントアポ蛋白 / 微小転移 / 末梢血 / 腺癌細胞 / 肺癌 / lung adenocarcinoma / autoantibody / radiation pneumonitis / idiopathic interstitial pneumonia / alveolar type II cells / 生体防御 / 膠原病合併間質性肺炎 / 放射線肺臓炎 / A549細胞 / 肺腺がん / 自己抗体 / 放射性肺臓炎 / 特発性間質性肺炎 / 肺胞II型細胞 / アデルカルシノーマ(腺癌) / SAT-I遺伝子 / ガングリオシドGM3(SAT-I) / アデノカルシノーマ(腺癌) / イレッサ(ゲフィチニブ) / 遺伝子診断 / SAT-I遣伝子 / ガングリオシドGM 3(SAT-I) / 抗癌剤感受性 / 非小細胞肺癌 Less

the efficacy of nintedanib for expression of surfactant protein
- Principal Investigator
  
  Otsuka Mitsuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibitionPrincipal Investigator
- Principal Investigator
  
  Takahashi Hiroki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR
- Principal Investigator
  
  Hasegawa Yoshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Pulmonary collectin regulates the severity of Streptococcus pneumoniae infection
- Principal Investigator
  
  Kuronuma Koji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant proteinPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Therapeutic application of lung collectin in acute lung injuryPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI HIROKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Pulmonary collectin regulates drug-induced lung injury.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
ガングリオシドGM3合成酵素遺伝子診断による非小細胞肺癌の抗癌剤感受性の予測
- Principal Investigator
  
  井ノ口仁一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku Pharmaceutical University
Host defense system in the lung using pulmonary surfactant proteins and Toll-like reosptors
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Mechanisms of innate immune surveillance by pulmonary surfactant proteins and their clinical application to respiratory infection.
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Navigation System through Bronchiolo-Alveolar Space by Virtual Microscopic Bronchoscopy based on Three Dimensional Coned-Beam Micro CT Data
- Principal Investigator
  
  NATORI Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Sapporo Medical University School of Medicine
Regulation of TLR by surfactant proteins in interstitial pneumoniaPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University School of Medicine
Innate immune host defense mediated by pulmonary sutfactant proteins and Toll-like receptors, and its clinical application.
- Principal Investigator
  
  KUROKI Yoshto
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Type II pneumocytes as a protective factor against interstitial lung injuryPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University School of Medicine
Clinical application for pathophysiological analysis, diagnosis and treatment of lung diseases by genes and their products expressed in alveolar type II cells.
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Detection of lung adenocareinoma cells in peripheral blood by RT-PCR analysis for mRNA of surfactant protein
- Principal Investigator
  
  ABE Shosaku
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
MOLECULAR BIOLOGICAL STUDY FOR EFFECT OF PULMONARY SURFACTANT PROTEINS ON HOST DEFENSE MECHANISM IN LUNGPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  SAPPORO MEDICAL UNIVERSITY
The signifficance of surfactant proteins in interstitial pneumonia and their clinical applicationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  SAPPORO MEDICAL UNIVERSITY

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014
- Author(s)
  高橋弘毅、千葉弘文、大塚満雄
- Total Pages
  136
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-26461164
[Book] 間質性肺疾患の診断・検査-画像と病理がわかる:E. 疾患マーカー・特殊検査の手順と解釈:1b. 疾患マーカー:サーファクタント蛋白質(SP-A, SP-D). 間質性肺疾患診療マニュアル(改訂第2版2014
- Author(s)
  高橋弘毅 (久保惠嗣、藤田次郎編)
- Publisher
  東京 : 南江堂
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 総論治療1.生活習慣と薬物療法.監修.インフォームドコンセントのための図解シリーズびまん性肺疾患と特発性肺炎2014
- Author(s)
  高橋弘毅、千葉弘文、大塚満雄
- Publisher
  東京 : 医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 間質性肺疾患診療マニュアル2014
- Author(s)
  高橋　弘毅
- Total Pages
  403
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-26461164
[Book] VIII. IPF の臨床と診断: 5. 新しい線維化マーカー( 2 ) SP-A,SP-D. 特発性肺線維症(IPF) (改訂版)2013
- Author(s)
  高橋弘毅, 白鳥正典 (杉山幸比古編)
- Publisher
  大阪 : 医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 初診時の対応. 特発性間質性肺炎の治療と管理2013
- Author(s)
  黒沼幸治、高橋弘毅 (杉山幸比古編)
- Publisher
  東京:克誠堂出版
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 特発性肺線維症 (IPF) (改訂版)2013
- Author(s)
  高橋弘毅、白鳥正典
- Publisher
  医療ジャーナル社
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 7.呼吸器系の疾患:間質性肺疾患:3)非特異性間質性肺炎.内科学(第10 版)2013
- Author(s)
  高橋弘毅 (矢崎義雄総編)
- Publisher
  東京 : 朝倉書店
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 14 章呼吸器疾患:11-1 特発性間質性肺炎. 内科学2012
- Author(s)
  高橋弘毅 (門脇孝、永井良三総編)
- Publisher
  東京:西村書店
- Data Source
  KAKENHI-PROJECT-23591154
[Book] 間質性肺疾患診療マニュアル(間質性肺疾患の診断・検査:E1B.サーファクタント蛋白質(SP-A, SP-D))(杉山幸比古、藤田次郎編)東京2010
- Author(s)
  高橋弘毅
- Publisher
  南光堂
- Data Source
  KAKENHI-PROJECT-20590930
[Book] Annual Rewiew 呼吸器2010(III. 診断の進歩:3.肺線維症におけるバイオマーカーの最近の知見)(永井厚志他編)東京2010
- Author(s)
  高橋弘毅、白鳥正典、千葉弘文
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20590930
[Book] Idiopathic Pulmonary Fibrosis (Lung Biology in Health and Disease)(Lynch JP)2004
- Author(s)
  Takahashi H
- Total Pages
  22
- Publisher
  Marcel Dekker
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590819
[Book] Idiopathic Pulmonary Fibrosis (Lung Biology in Health and Disease)2004
- Author(s)
  Takahashi H
- Total Pages
  22
- Publisher
  Lynch JP(Marcel Dekker)
- Data Source
  KAKENHI-PROJECT-15590819
[Journal Article] Respiratory reactance in forced oscillation technique reflects disease stage and predicts lung physiology deterioration in idiopathic pulmonary fibrosis2020
- Author(s)
  Mori Y、Nishikiori H、Chiba H、Yamada G、Kuronuma K、Takahashi H.
- Journal Title
  
  Respir Physiol Neurobiol
  
  Volume: 275 Pages: 103386-103386
- DOI
  10.1016/j.resp.2020.103386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis2020
- Author(s)
  Yoshikawa Takumi、Otsuka Mitsuo、Chiba Hirofumi、Ikeda Kimiyuki、Mori Yuki、Umeda Yasuaki、Nishikiori Hirotaka、Kuronuma Koji、Takahashi Hiroki
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 20 Issue: 1 Pages: 2727-2727
- DOI
  10.1186/s12890-020-1060-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
[Journal Article] Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis2019
- Author(s)
  Asai Yuichiro、Chiba Hirofumi、Nishikiori Hirotaka、Kamekura Ryuta、Yabe Hayato、Kondo Shun、Miyajima Satsuki、Shigehara Katsunori、Ichimiya Shingo、Takahashi Hiroki
- Journal Title
  
  Respiratory Research
  
  Volume: 20 Issue: 1 Pages: 244-244
- DOI
  10.1186/s12931-019-1216-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08150, KAKENHI-PROJECT-18K09323, KAKENHI-PROJECT-18H02632, KAKENHI-PROJECT-17K09662
[Journal Article] Immunogenicity of pneumococcal vaccines in comorbid autoimmune and chronic respiratory diseases.2019
- Author(s)
  Kuronuma K, Takahashi H.
- Journal Title
  
  Hum Vaccin Immunother
  
  Volume: - Pages: 1-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment2018
- Author(s)
  Kuronuma Koji、Honda Hiroyuki、Mikami Tessei、Saito Atsushi、Ikeda Kimiyuki、Otsuka Mitsuo、Chiba Hirofumi、Yamada Gen、Sato Toyotaka、Yokota Shin-ichi、Takahashi Hiroki
- Journal Title
  
  Vaccine
  
  Volume: 36 Issue: 33 Pages: 4968-4972
- DOI
  10.1016/j.vaccine.2018.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K15956
[Journal Article] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis2018
- Author(s)
  Takahashi Youhei、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Ikeda Kimiyuki、Kobayashi Tomofumi、Ariki Shigeru、Takahashi Motoko、Sasaki Yasushi、Takahashi Hiroki
- Journal Title
  
  Respir Res
  
  Volume: 19 Issue: 1 Pages: 34-34
- DOI
  10.1186/s12931-018-0736-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09181, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-17K09662, KAKENHI-PROJECT-18K08150
[Journal Article] Significance of molecular biomarkers in idiopathic pulmonary fibrosis: A mini review2018
- Author(s)
  Chiba Hirofumi、Otsuka Mitsuo、Takahashi Hiroki
- Journal Title
  
  Respiratory Investigation
  
  Volume: 56 Issue: 5 Pages: 384-391
- DOI
  10.1016/j.resinv.2018.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Poorer Prognosis of Idiopathic Pleuroparenchymal Fibroelastosis Compared with Idiopathic Pulmonary Fibrosis in Advanced Stage2018
- Author(s)
  Shioya Makoto、Otsuka Mitsuo、Yamada Gen、Umeda Yasuaki、Ikeda Kimiyuki、Nishikiori Hirotaka、Kuronuma Koji、Chiba Hirofumi、Takahashi Hiroki
- Journal Title
  
  Canadian Respiratory Journal
  
  Volume: 2018 Pages: 1-7
- DOI
  10.1155/2018/6043053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09619, KAKENHI-PROJECT-17K09662
[Journal Article] Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation2018
- Author(s)
  Ohkoshi Yasuo、Sato Toyotaka、Wada Takayuki、Fukushima Yukari、Murabayashi Hiromi、Takakuwa Yasunari、Nishiyama Kaoru、Honda Hiroyuki、Shiraishi Tsukasa、Kuronuma Koji、Takahashi Hiroki、Nakajima Chie、Suzuki Yasuhiko、Yokota Shin-ichi
- Journal Title
  
  J Infect Chemother
  
  Volume: 印刷中 Issue: 8 Pages: 674-681
- DOI
  10.1016/j.jiac.2018.01.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09181, KAKENHI-PROJECT-17K15688
[Journal Article] Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke2017
- Author(s)
  Takamiya Rina、Uchida Koji、Shibata Takahiro、Maeno Toshitaka、Kato Masaki、Yamaguchi Yoshiki、Ariki Shigeru、Hasegawa Yoshihiro、Saito Atsushi、Miwa Soichi、Takahashi Hiroki、Akaike Takaaki、Kuroki Yoshio、Takahashi Motoko
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 8304-8304
- DOI
  10.1038/s41598-017-08588-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16H04758
[Journal Article] Surfactant protein A inhibits growth and adherence of uropathogenic Escherichia coli to protect the bladder from infection.2017
- Author(s)
  Hashimoto J., Takahashi M., Satio A., Murata M., Kurimura Y., Nishitani C., Takamiya R., Uehara Y., Hasegawa Y., Hiyama Y., Sawada N., Takahashi S., Masumori N., Kuroki Y., Ariki S.
- Journal Title
  
  J. Immunol.
  
  Volume: 198 Issue: 7 Pages: 2898-2905
- DOI
  10.4049/jimmunol.1502626
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339
[Journal Article] Surfactant protein A down-regulates epidermal growth factor receptor by mechanisms different from those of surfactant protein D2017
- Author(s)
  Yoshihiro Hasegawa, Motoko Takahashi, Shigeru Ariki, Atsushi Saito, Yasuaki Uehara, Rina Takamiya, Koji Kuronuma, Hirofumi Chiba, Yuji Sakuma, Hiroki Takahashi, Yoshio Kuroki
- Journal Title
  
  J Bill Chem
  
  Volume: 292 Issue: 45 Pages: 18565-18576
- DOI
  10.1074/jbc.m117.800771
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] Treatment of pulmonary fibrosis with siRNA against a collagen-specific chaperone HSP47 in vitamin A-coupled liposomes.2017
- Author(s)
  Otsuka M, Shiratori M, Chiba H, Kuronuma K, Sato Y, Niitsu Y, Takahashi H.
- Journal Title
  
  Experimental Lung Research
  
  Volume: 43 Pages: 271-282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone.2017
- Author(s)
  Ikeda K, Shiratori M, Chiba H, Nishikiori H, Yokoo K, Saito A, Hasegawa Y, Kuronuma K, Otsuka M, Yamada G, Takahashi H.
- Journal Title
  
  Respiratoru Medicine
  
  Volume: 131 Pages: 184-191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09662
[Journal Article] SP-Dによる変異型EGFR肺がんの制御機構2017
- Author(s)
  長谷川喜弘, 梅田泰淳, 大塚満雄, 有木茂, 高宮里奈, 齋藤充史, 黒沼幸治, 千葉弘文, 高橋弘毅, 黒木由夫, 高橋素子
- Journal Title
  
  分子呼吸器病
  
  Volume: 21 Pages: 80-83
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] Surfactant Protein A (SP-A) and SP-A-derived Peptide Attenuate Chemotaxis of Mast Cells Induced by Human β-defensin 3.2017
- Author(s)
  Uehara Y., Takahashi M., Murata M., Saito A., Takamiya R., Hasegawa Y., Kuronuma K., Chiba H., Hashimoto J., Sawada N., Takahashi H., Kuroki Y., Ariki S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485 Issue: 1 Pages: 107-112
- DOI
  10.1016/j.bbrc.2017.02.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461, KAKENHI-PROJECT-16K08693, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-15K09181
[Journal Article] Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients2017
- Author(s)
  Umeda Y、Hasegawa Y、Otsuka M、Ariki S、Takamiya R、Saito A、Uehara Y、Saijo H、Kuronuma K、Chiba H、Ohnishi H、Sakuma Y、Takahashi H、Kuroki Y、Takahashi M
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 46 Pages: 6432-6445
- DOI
  10.1038/onc.2017.253
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07123, KAKENHI-PROJECT-17K07339, KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone2017
- Author(s)
  Ikeda Kimiyuki、Shiratori Masanori、Chiba Hirofumi、Nishikiori Hirotaka、Yokoo Keiki、Saito Atsushi、Hasegawa Yoshihiro、Kuronuma Koji、Otsuka Mitsuo、Yamada Gen、Takahashi Hiroki
- Journal Title
  
  Respir Med.
  
  Volume: 131 Pages: 184-191
- DOI
  10.1016/j.rmed.2017.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19460, KAKENHI-PROJECT-16K19461
[Journal Article] SP-DによるEGFR制御機構2017
- Author(s)
  長谷川喜弘、高橋素子、高橋弘毅
- Journal Title
  
  BIO Clinica
  
  Volume: 14 Pages: 130-134
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] 肺サーファクタント蛋白質SP-Dの肺がんに対する新たな役割2016
- Author(s)
  長谷川喜弘、高橋素子、高橋弘毅
- Journal Title
  
  Medical Science Digest
  
  Volume: 42 Pages: 398-402
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] SP-A及びSP-A由来ペプチドはヒトβ-ディフェンシン3による肥満細胞の遊走を抑制する2016
- Author(s)
  有木茂, 上原康昭, 村田雅樹, 高宮里奈, 長谷川喜弘, 齋藤充史, 千葉弘文, 黒沼幸治, 高橋素子, 高橋弘毅, 黒木由夫
- Journal Title
  
  分子呼吸器病
  
  Volume: 20 Pages: 120-123
- Data Source
  KAKENHI-PROJECT-16K19461
[Journal Article] N-glycans of growth factor receptors: their role in receptor function and disease implications.2016
- Author(s)
  Takahashi M, Hasegawa Y, Gao C, Kuroki Y, Taniguchi N.
- Journal Title
  
  Clinical Science
  
  Volume: 130 Issue: 20 Pages: 1781-1792
- DOI
  10.1042/cs20160273
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-16K01849, KAKENHI-PROJECT-26440058, KAKENHI-PROJECT-16K19461
[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.2015
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
- Journal Title
  
  Oncogene
  
  Volume: 34 Pages: 838-845
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling2015
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
- Journal Title
  
  Oncogene
  
  Volume: 34 Issue: 7 Pages: 838-845
- DOI
  10.1038/onc.2014.20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591154, KAKENHI-PROJECT-26860611, KAKENHI-PROJECT-25461194
[Journal Article] Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences.2014
- Author(s)
  Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H.
- Journal Title
  
  Am J Respir Crit Care Med.
  
  Volume: 190 Pages: 773-779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.2014
- Author(s)
  Hasegawa Y,Takahashi H, et.al.
- Journal Title
  
  Oncogene
  
  Volume: 該当なし
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis.2014
- Author(s)
  Nishikiori H, Chiba H, Ariki S, Kuronuma K, Otsuka M, Shiratori M, Ikeda K, Watanabe A, Kuroki Y, Takahashi H.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 14 Pages: 196-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461164
[Journal Article] 呼吸器疾患の診断・治療(I)間質性肺炎2013
- Author(s)
  千葉弘文, 高橋弘毅
- Journal Title
  
  医学と薬学
  
  Volume: 69(1) Pages: 27-32
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 【特発性間質性肺炎-この10年の進歩と今後の展望-】特発性間質性肺炎の診断と治療の進歩診断・疫学関連わが国における疫学調査:北海道STUDY2013
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  日胸
  
  Volume: 72
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] Pilot study exploring lung allograft surfactant protein A (SP-A) expression in association with lung transplant outcome2013
- Author(s)
  D'Ovidio F, Kaneda H, Chaparro C, Mura M, Lederer D, Di Angelo S, Takahashi H, Gutierrez C, Hutcheon M, Singer LG, Waddell TK, Floros J, Liu M, Keshavjee S
- Journal Title
  
  Am J Transplant
  
  Volume: 13(10) Issue: 10 Pages: 2722-9
- DOI
  10.1111/ajt.12407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特発性肺線維症患者におけるSP-AとSP-Dの肺内動態の差異ついての検討2013
- Author(s)
  織博貴, 千葉弘文, 大塚満雄, 高橋弘毅
- Journal Title
  
  日肺サーファクタント・界面医会誌
  
  Volume: 44 Pages: 63-5
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 呼吸器疾患の診断と治療最近の進歩特発性間質性肺炎2013
- Author(s)
  千葉弘文, 高橋弘毅
- Journal Title
  
  北海道医報
  
  Volume: 1134 Pages: 44-6
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] シアル化糖鎖抗原(KL-6), サーファクタントプロテインA, サーファクタントプロテインD2013
- Author(s)
  高橋弘毅
- Journal Title
  
  内科
  
  Volume: 111 Pages: 1304-1304
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特発性肺線維症の疫学調査(北海道study)による新知見2013
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  呼吸器内科
  
  Volume: 23(4) Pages: 337-41
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 血清蛋白, その他の生化学検査シアル化糖鎖抗原(KL-6), サーファクタントプロテインA, サーファクタントプロテインD2013
- Author(s)
  高橋弘毅
- Journal Title
  
  内科
  
  Volume: 111(6) Pages: 1304-1304
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 32012
- Author(s)
  Saito A., et al
- Journal Title
  
  J.Biol.Chem.
  
  Volume: (In press) Issue: 18 Pages: 15034-43
- DOI
  10.1074/jbc.m111.308056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790764, KAKENHI-PROJECT-23591154, KAKENHI-PROJECT-24591686
[Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3.2012
- Author(s)
  Saito H, Takahashi H, et.al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 間質性肺疾患Up-To-Date北海道studyはじめて明らかになった特発性肺線維症の疫学2012
- Author(s)
  千葉弘文, 夏井坂元基, 高橋弘毅
- Journal Title
  
  THE LUNG-perspective
  
  Volume: 20(3) Pages: 243-5
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特発性間質性肺炎の疫学2011
- Author(s)
  高橋弘毅
- Journal Title
  
  最新医学
  
  Volume: 66 Pages: 19-23
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] IPFのバイオマーカー2011
- Author(s)
  高橋弘毅
- Journal Title
  
  呼吸器内科
  
  Volume: 19 Pages: 597-604
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特集特発性間質性肺炎-最近の進歩と展望. 病態と治療:特発性間質性肺炎の疫学2011
- Author(s)
  高橋弘毅、千葉弘文
- Journal Title
  
  最新医学
  
  Volume: 66(6) Pages: 1103-1107
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特発性肺線維症の病態と特徴2011
- Author(s)
  高橋弘毅
- Journal Title
  
  綜合臨床
  
  Volume: 60 Pages: 2385-2390
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] 特集特発性肺線維症(IPF). IPFのバイオマーカー2. SP-D, SP-A2011
- Author(s)
  高橋弘毅, 白鳥正典, 千葉弘文
- Journal Title
  
  呼吸器内科
  
  Volume: 19(6) Pages: 597-604
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] レジオネラ菌に対する肺コレクチンの生体防御機構エンドキシン2011
- Author(s)
  齋藤充史, 有木茂, 西谷千明, 高橋素子, 高橋弘毅, 黒木由夫
- Journal Title
  
  自然免疫研究
  
  Volume: 14 Pages: 79-82
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] びまん性肺疾患のマイル・ストーン特発性肺線維症の病態と特徴2011
- Author(s)
  高橋弘毅, 千葉弘文, 大塚満雄
- Journal Title
  
  総合臨床
  
  Volume: 60(12) Pages: 2385-90
- Data Source
  KAKENHI-PROJECT-23591154
[Journal Article] Pulmonary Collectins Protect Macrophages against Pore-forming Activity of Legionella pneumophila and Suppress Its Intracellular Growth.2010
- Author(s)
  Sawada K, Ariki S, Kojima T, Saito A, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Mitsuzawa H, Yokota S, Sawada N, Fujii N, Takahashi H, Kuroki Y.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Development of an enzyme-linked immunosorbent assay for measurement of rat pulmonary surfactant protein D using monoclonal antibodies.2010
- Author(s)
  Murata M, Otsuka M, Mizuno H, Shiratori M, Miyazaki S, Nagae H, Kanazawa S, Hamaoki M, Kuroki Y, Takahashi H.
- Journal Title
  
  Exp Lung Res 36
  
  Pages: 463-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Development of an enzyme-linked immunosorbent assay for measurement of rat pulmonary surfactant protein D using monoclonal antibodies.2010
- Author(s)
  Murata M, Takahashi H, et al.
- Journal Title
  
  Exp Lung Res
  
  Volume: 36・8 Pages: 463-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Pulmonary collectins protect macrophages against pore-forming activity of legionella pneumophila and suppress its intracellular growth.2010
- Author(s)
  Sawada K, Takahashi H, et al.
- Journal Title
  
  J Biol Chem
  
  Volume: 285・11 Pages: 8434-8443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Pulmonary surfactant protein D binds MD-2 through the carbohydrate recognition domain.2008
- Author(s)
  Nie X, Nishitani C, Yamazoe M, Ariki S, Takahashi M, Shimizu T, Mitsuzawa H, Sawada K, Smith K, Crouch E, Nagae H, Takahashi H, Kuroki Y.
- Journal Title
  
  Biochemistry 47
  
  Pages: 12878-12885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] Pulmonary Surfactant Protein D Inhibits Lipopolysaccharide (LPS)-induced Inflammatory cell responses by altering LPS binding to its receptors.2008
- Author(s)
  Yamazoe M, Nishitani C, Takahashi M, Katoh T, Ariki S, Shimizu T, Mitsuzawa H, Sawada K, Voelker DR, Takahashi H, Kuroki Y.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 35878-35888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590930
[Journal Article] GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.2007
- Author(s)
  Noguchi M, Suzuki T, Kabayama K, Takahashi H, Chiba H, Shiratori M, Abe S, Watanabe A, Satoh M, Hasegawa T, Tagami S, Ishii A, Saito M, Kaneko M, Iseki K, Igarashi Y, Inokuchi J.
- Journal Title
  
  Cancer Science 98
  
  Pages: 1625-1632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18014001
[Journal Article] Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.2007
- Author(s)
  Takahashi T
- Journal Title
  
  Respirology (in press)
- Data Source
  KAKENHI-PROJECT-18390241
[Journal Article] Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.2007
- Author(s)
  Takahashi T
- Journal Title
  
  Respirology 12
  
  Pages: 642-653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390241
[Journal Article] Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis2007
- Author(s)
  Takahashi T
- Journal Title
  
  Respirology 12
  
  Pages: 642-653
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390241
[Journal Article] Autoantibody to alanyl-tRNA synthetase in patients with idiop athic pulmonary fibrosis2007
- Author(s)
  Takahashi, T
- Journal Title
  
  Respirology 12
  
  Pages: 642-653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390241
[Journal Article] Development of Phantoms for Fine Resolution Test in Ultrasonography.2006
- Author(s)
  Natori H, Inaba M, Takahashi K, Mitani M, Narai K, Kato J.
- Journal Title
  
  European Radiology 16(suppl I )
  
  Pages: 474-474
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500322
[Journal Article] Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D.2006
- Author(s)
  Takahashi H
- Journal Title
  
  Respirology 11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Monitoring markers of disease activity of interstitial lung diseases with serum surfactant proteins A and D.2006
- Author(s)
  Takahashi H
- Journal Title
  
  Respirology 11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Pulmonary surfactant protein A and D : innate immune function and biomarkers for lung disease.2005
- Author(s)
  Takahashi H, et al.
- Journal Title
  
  Current Pharmaceutical Design (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590819
[Journal Article] Pulmonary surfactant proyteins A and D : innate immune functions and biomarkers for lung disease.2005
- Author(s)
  Takahashi H
- Journal Title
  
  Current Pharmaceutical Design 12
  
  Pages: 589-598
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Pulmnary surfactant proteins A and D ; innate immune functions and biomarkers for lung diseases.2005
- Author(s)
  Takahashi H
- Journal Title
  
  Current Pharmaceutical Design 12
  
  Pages: 589-298
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Pulmonary surfactant proteins A and D : innate immune functions and biomarkers for lung disease.2005
- Author(s)
  Takahashi H
- Journal Title
  
  Current Pharmaceutical Design 12
  
  Pages: 589-598
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Pulmonary surfactant proteins A and D : innate immune functions and biomarkers.2005
- Author(s)
  Takahashi, H.
- Journal Title
  
  Current Pharmaceutical Design (in press)
- Data Source
  KAKENHI-PROJECT-16390235
[Journal Article] Elevated serum surfactant protein A and D in pulmonary alveolar microlithiasis.2004
- Author(s)
  Takahashi H
- Journal Title
  
  Respirology (掲載決定)(in Press)
- Data Source
  KAKENHI-PROJECT-16500322
[Journal Article] Surfactant proteins in the pathophysiology of pulmonary fibrosis2004
- Author(s)
  Takahashi H
- Journal Title
  
  Idiopathic Pulmonary Fibrosis(ed. Lynch JP)Lung Biology in Health and Disease(Marcel Dekker)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590819
[Journal Article] Pulmonary surfactant protein A and D : innate immune function and biomarkers for lung disease
- Author(s)
  Takahashi H, et al.
- Journal Title
  
  Current Pharmaceutical Design (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590819
[Presentation] Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF2019
- Author(s)
  113.Yoshikawa T, Otsuka M, Ikeda K, Mori Y, Umeda Y, Nishikiori H, Miyajima S, Takahashi M, Kuronuma K, Chiba H, Takahashi H
- Organizer
  European Respiratory Society Annual Congress: 2019 September 28-October 2: Madrid, Spain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] 抗線維化薬の治療効果の指標としての血清SP-A、SP－D, KL－6の意義2019
- Author(s)
  吉川　匠、大塚満雄、池田貴美之、錦織博貴、千葉弘文、高橋弘毅
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] 特発性肺線維症患者におけるニンテダニブの有害事象と忍容性の後方視的検討2019
- Author(s)
  大塚満雄、吉川　匠、池田貴美之、錦織博貴、千葉弘文、高橋弘毅
- Organizer
  日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-17K09619
[Presentation] Pneumococcal vaccination in interstitial lung disease patients receiving systemic immunosuppressive treatment.2017
- Author(s)
  Koji Kuronuma, Hiroyuki Honda, Tessei Mikami, Yuichiro Asai, Youhei Takahashi, Tomofumi Kobayashi, Atsushi Saito, Kimiyuki Ikeda, Hirotaka Nishikiori, Mamoru Takahashi, Mitsuo Otsuka, Hirofumi Chiba, Gen Yamada, Hiroki Takahashi, Toyotaka Sato
- Organizer
  27th European Respiratory Society Annual Congress　2017.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09181
[Presentation] Retrospective analysis of microbiome in idiopathic pulmonary fibrosis.2017
- Author(s)
  Youhei Takahashi, Astushi Saito, Kimiyuki Ikeda, Koji Kuronuma, Tomofumi Kobayashi, Yuichiro Asai, Hirotaka Nishikiori, Gen Yamada, Hirofumi Chiba, Yasushi Sasaki, Hiroki Takahashi, Mitsuo Otsuka, Mamoru Takahashi
- Organizer
  27th European Respiratory Society Annual Congress　2017.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09181
[Presentation] 肺サーファクタントタンパク質Dは変異型EGFRの活性化を阻害し、肺腺がんの進展を抑制する2017
- Author(s)
  長谷川喜弘、梅田泰淳、大塚満雄、有木茂、高宮里奈、齋藤充史、高橋弘毅、黒木由夫、高橋素子
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 肺サーファクタント蛋白質DによるEGFR遺伝子変異陽性肺がんの制御機構2016
- Author(s)
  長谷川喜弘, 高橋素子, 有木茂, 高宮里奈，齋藤充史, 高橋弘毅
- Organizer
  第114回北海道癌談話会例会
- Place of Presentation
  札幌医科大学（札幌市）
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] SP-Dによる変異型EGFR肺がんの制御機構2016
- Author(s)
  長谷川喜弘, 梅田泰淳, 高橋素子, 大塚満雄, 有木茂, 高宮里奈，齋藤充史, 高橋弘毅, 黒木由夫
- Organizer
  第15回肺サーファクタント分子病態研究会
- Place of Presentation
  札幌医科大学（札幌市）
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 肺サーファクタント蛋白質Dによる変異型EGFRの制御機構2016
- Author(s)
  長谷川喜弘, 佐久間裕司, 高橋素子
- Organizer
  第75回日本癌学会学術総会, 2016年10月6日～8日
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19461
[Presentation] 原発性肺腺癌におけるEGFR遺伝子変異とTTF-1、SP-A、SP-D発現の検討2015
- Author(s)
  大塚満雄、梅田泰淳、成田欣史、黒沼幸治、山田玄、高橋弘毅
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] Diffusing capacity for carbon monoxide (DLco) may predict appearance of pulmonary hypertension in idiopathic pulmonary fibrosis2013
- Author(s)
  Otsuka M, Kitamura Y, Yokoo K, Ikeda K,Shioya M, Nishikiori H, Shiratori M,Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] IPF患者におけるSP-AとSP-Dの血中移行についての検討2013
- Author(s)
  錦織博貴、高橋弘毅ら
- Organizer
  日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Serum surfactant protein D may predict the effect of pirfenidone in idiopathic pulmonary fibrosis2013
- Author(s)
  Ikeda K, Shiratori S, Yokoo K, Otsuka M,Chiba H, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Idiopathic pulmonary upper lobe fibrosis shows distinct features and poor prognosis compared to idiopathic pulmonary fibrosis2013
- Author(s)
  Shioya M, Otsuka M, Kitamura Y, Yokoo K,Ikeda K, Nishikiori H, Shiratori M, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] 血清SP-D異常低値を呈する肺癌症例の検討2013
- Author(s)
  成田欣史、高橋弘毅ら
- Organizer
  日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Difference in the dynamic state between SP-A and SP-D in the lung.2013
- Author(s)
  Nishikiori H, Takahashi H et.al.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Serum surfactant protein D may predict the effect of pirfenidone in idiopathic pulmonary fibrosis2013
- Author(s)
  Ikeda K, Takahashi H et.al.
- Organizer
  European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Surfactant Proteins A And D Suppress Epidermal Growth Factor Signaling Through Interactions With N-Glycans Of Receptor.2013
- Author(s)
  Hasegawa Y,Takahashi H et.al.
- Organizer
  The 18th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Surfactant Proteins A And D Suppress Epidermal Growth Factor Signaling Through Interactions With N-Glycans Of Receptor2013
- Author(s)
  Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Takamiya R, Uehara Y,Hashimoto J, Takahashi H, and Kuroki Y
- Organizer
  18th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] HSP47siRNA targeting to myofibroblasts attenuates bleomycin-induced pulmonary fibrosis2013
- Author(s)
  Otsuka M, Shiratori M, Kuronuma K,Takahashi H
- Organizer
  22th European Respiratory Society Annual Congress
- Place of Presentation
  Wien, Austria
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] 肺コレクチンによるEGFシグナルの制御機構2013
- Author(s)
  長谷川喜弘、高橋弘毅ら
- Organizer
  日本生化学会大会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Significance of serum surfactant protein D for combined pulmonary fibrosis with emphysema in idiopathic pulmonary fibrosis2013
- Author(s)
  Yokoo K, Shiratori M, Natsuizaka M, Ikeda K,Otsuka M, Chiba H, Yamada G, Koba H,Takahashi H
- Organizer
  18th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Serum surfactant protein D (SP-D) and annual decline of diffusion capacity are prognostic factors for combined pulmonary fibrosis withemphysema (CPFE) in idiopathic pulmonary fibrosis (IPF)2013
- Author(s)
  Yokoo K, Shiratori M, Ikeda K, Natsuizaka M,Otsuka M, Koba H, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Difference in the dynamic state between SP-A and SP-D in the lung2013
- Author(s)
  Nishikiori H, Chiba H, Otsuka M, Ikeda K,Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Subtypes of pulmonary emphysema on HRCT affect prognosis on combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis2013
- Author(s)
  Shiratori M, Yokoo K, Ikeda K, Natsuizaka M,Umeda Y, Kitamura Y, Otsuka M, Chiba H,Koba H, Takahashi H
- Organizer
  23th European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia2013
- Author(s)
  Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
- Organizer
  22th European Respiratory Society Annual Congress
- Place of Presentation
  Wien,Austria
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Relationship between serum SP-A and pulmonary hypertension in interstitial lung diseases2012
- Author(s)
  Kitamura Y, Otsuka M, Umeda Y, Shiratori M, Takahashi H
- Organizer
  107th International Conference of American Thoracic Society
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Epidemiological survey of patients with idiopathic interstitial pneumonias using clinical personal records in Hokkaido, Japan2012
- Author(s)
  Natsuizaka M, Chiba H, Shiratori M, Mori M,Sugiyama Y, Takahashi H
- Organizer
  107th International Conference of American Thoracic Society
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Clinical characteristics of combined pulmonary fibrosis and emphysema2012
- Author(s)
  Umeda Y, Otsuka M, Kitamura Y, Shiratori M, Takahashi H
- Organizer
  107th International Conference of American Thoracic Society
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Effect of HSP47siRNA Targeting to The Lung Myofibroblast on Bleomycin-Induced Pulmonary Fibrosis2012
- Author(s)
  Otsuka M, Shiratori M, Takahashi H
- Organizer
  107th International Conference of American Thoracic Society
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Pulmonary Collectins Attenuate Autophagy Induce By L.Pneumophila Infection2011
- Author(s)
  Saito A, Ariki S, Nishitani C, Takahashi M,Takahashi H, Kuroki Y
- Organizer
  106th International Conference of American Thoracic Society
- Place of Presentation
  Denver, U.S.A.
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Pulmonary Collectins Attenuate Autophagy Induce By L.Pneumophila Infection.2011
- Author(s)
  Saito S, Takahashi H et.al.
- Organizer
  The American Thoracic Society International Conference
- Place of Presentation
  米国コロラド州
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011
- Author(s)
  黒沼幸治、高橋弘毅ら
- Organizer
  日本肺サーファクタント界面医学会総会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] 肺線維症におけるHSP-47siRNAを用いた治療戦略2011
- Author(s)
  大塚満雄、高橋弘毅ら
- Organizer
  肺サーファクタント分子病態研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] Surfactant protein A modulate bleomycininduced lung injury in toll-like receptor 2 dependent pathway.2010
- Author(s)
  Kuronuma K, Kudo K, Kuroki Y, Takahashi H.
- Organizer
  In : 20^<th> European Respiratory Society Annual Congress
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] Surfactant protein A modulate bleomycin-induced lung injury in toll-like receptor 2 dependent pathway2010
- Author(s)
  Kuronuma K, Takahashi H, et al
- Organizer
  European Respiratory Society
- Place of Presentation
  スペインバルセロナ
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] Surfactant protein D in sera as a prognostic factor of idiopathic pulmonary fibrosis.2008
- Author(s)
  Shiratori M, Kanai A, Otsuka M, Chiba H, Takahashi H.
- Organizer
  In : The 103^<th> International Conference of American Thoracic Society
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] 間質性肺炎とバイオマーカー2008
- Author(s)
  高橋弘毅
- Organizer
  日本呼吸器学会
- Place of Presentation
  兵庫県神戸市神戸コンベンションセンター
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] Pulmonary collectins exhibit bactericidal activity against Legionella pneumophila.2008
- Author(s)
  Sawada K, Ariki S, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Yokota S, Fujii N, Takahashi H, Kuroki Y.
- Organizer
  In : The 8^<th> Awaji International Forum on Infection and Immunity
- Place of Presentation
  Awaji, Japan
- Data Source
  KAKENHI-PROJECT-20590930
[Presentation] 特発性肺線維症における血清マーカーとピルフェニドンの治療効果との関連についての検討
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京国際フォーラム(東京都千代田区)
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 肺腺癌EGFR-TKI治療のバイオマーカーとしての血清SP-A、SP-D
- Author(s)
  梅田泰淳, 大塚満雄, 成田欣史, 黒沼幸治, 高橋弘毅
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D
- Author(s)
  千葉弘文、高橋弘毅ら
- Organizer
  日本肺サーファクタント・界面医学会学術研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] サーファクタント蛋白質AおよびDのEGFシグナル制御を介した抗腫瘍作用
- Author(s)
  長谷川喜弘、高橋弘毅ら
- Organizer
  日本生化学会北海道支部　支部例会第50回記念大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591154
[Presentation] EGFR遺伝子変異陽性肺腺癌におけるバイオマーカーとしての血清SP-A, SP-D, KL-6の有用性.
- Author(s)
  梅田泰淳, 大塚満雄, 成田欣史, 黒沼幸治, 高橋弘毅
- Organizer
  第55回日本肺癌学会学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2014-11-14 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-26461164
[Presentation] 特発性肺線維症におけるピルフェニドンの治療効果予測因子としての血清SP-D
- Author(s)
  池田貴美之, 白鳥正典, 横尾慶紀, 梅田泰淳, 汐谷心, 錦織博貴, 黒沼幸治, 大塚満雄, 千葉弘文, 高橋弘毅
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-26461164

1. KUROKI Yoshio (70161784)

# of Collaborated Projects: 10 results

# of Collaborated Products: 10 results
2. CHIBA Hirofumi (40347175)

# of Collaborated Projects: 6 results

# of Collaborated Products: 28 results
3. KURONUMA Koji (40563250)

# of Collaborated Projects: 5 results

# of Collaborated Products: 21 results
4. TAECAHASHI Motoko (00303941)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
5. SHIRATORI Masanori (40295366)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
6. Otsuka Mitsuo (10398323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
7. HASEGAWA YOSHIHIRO (90643180)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. KUDO Kazumi (90438002)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. ABE Shosaku (60113510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. IWAKI Daisuke (10315492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SANO Hitomi (80295344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. NISHITANI Chiaki (30381255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. SAITO ATSUSHI (00768939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. MURAKAMI Seiji (40315487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIRASAWA Michio (90264530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKAHASHI Toru (40347159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NATORI Hiroshi (00102260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. MITANI Masanobu (70200061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. TORIWAKI Junichiro (30023138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MORI Kensaku (10293664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIMIZU Takeyuki (10339137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MITSUZAWA Hiroaki (40325874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SAKUMA YUJI (10364514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 井ノ口仁一 (70131810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAGAE Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TAKAMIYA Rina

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
27. ARIKI Shigeru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 和田芳直

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 井口仁一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 谷口直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Hiroki 高橋 弘毅

TAKAHASHI Hiroki 高橋 弘毅

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Pulmonary fibrosis treatment with pulmonary surfactant as a TLR regulatory molecule and HSP47 inhibitionPrincipal Investigator

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Suppression of pulmonary injury and fibrosis by applying new action of pulmonary surfactant proteinPrincipal Investigator

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Therapeutic application of lung collectin in acute lung injuryPrincipal Investigator

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Pulmonary collectin regulates drug-induced lung injury.Principal Investigator

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Regulation of TLR by surfactant proteins in interstitial pneumoniaPrincipal Investigator

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Type II pneumocytes as a protective factor against interstitial lung injuryPrincipal Investigator

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Takahashi Hiroki 高橋弘毅

TAKAHASHI Hiroki 高橋弘毅

[Book] インフォームドコンセントのための図解シリーズ　びまん性肺疾患と特発性肺炎．2014

[Book] 総論治療1.生活習慣と薬物療法.監修.インフォームドコンセントのための図解シリーズびまん性肺疾患と特発性肺炎2014

[Book] 14 章呼吸器疾患:11-1 特発性間質性肺炎. 内科学2012