YOSHIDA Haruhiko 吉田晴彦

Researcher Number	60240305
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2015: 東京大学, 医学部附属病院, 登録研究員 2014: 東京大学, 医学部附属病院, その他 2013: 東京大学, 医学部附属病院, 臨床登録医 2004 – 2012: The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 2007 – 2008: The University of Tokyo, The University of TokyoHospital, Lecturer 2001 – 2003: Faculty of Medicin, The University of Tokyo, ASSISTANT, 医学部附属病院, 助手 1996 – 2001: 東京大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Medical pharmacy / Biological Sciences
Keywords	Principal Investigator Helicobacter pylori / CagA / ヘリコバクター・ピロリ / c-IAP2 / 胃癌 / スナネズミ / cagPAI / p53 / Core / TAF … More / TBP / NS5A / Predictor of Prognosis / Loss of Heterozygosity / Copy Number Amplification / Oligonucleotide Array / Chromosomal Instability / Gastric Cancer / ゲノム解析 / 胃粘膜上皮細胞 / マイクロダイセクション / 予後予測 / 遺伝子コピー数異常 / 予後規定因子 / LOH / コピー数増幅 / オリゴヌクレオチドアレイ / 染色体異常 / Carcinogenesis / Serum Responsive Element / Apoptosis / Anti-Apoptosis / Cellular Proliferation / 細胞内信号伝達 / NFκB / 発癌 / SRE / アポトーシス / アンチアポトーシス / 細胞増殖 / virulence / intracellular signaling pathways / Mongolian gerbil / Cag PAI / ヘリコバクタ・ピロリ / 病原性 / 細胞内信号伝達系 / NF-κB / Transcription / Hepatitis C virus (HCV) / 肝癌 / 転写因子 / NF-kB / 転写 / C型肝炎ウイルス / Virulence factor / recombinant VacA / Vacuolating cytotoxin / antibody / sequencing / vacuolation / VacA / 病態規定因子 / 組換えVacA / 空胞化毒素 / エピジェネティクス / SOCS3 / microRNA / インターフェロン / HCV / 非コードRNA / IFN / 非アルコール性脂肪肝炎 / 内臓脂肪 / Cox比例ハザードモデル / HBc抗体 / C型慢性肝炎 / HBV既感染 / 多変量解析 / ラジオ波焼灼療法 / HBV-DNA量 / 非B非C肝障害 / HBV-DNA / 非B非C肝癌 / 肝細胞癌 … More Except Principal Investigator 肝癌 / 肝細胞癌 / microRNA / 肝臓学 / MDM2 / UGT1A7 / SNP / DCP / cagPAI / Helicobacter pylori / 癌幹細胞 / 癌 / Cytokine / Hepatocellular carcinoma / Hepatitis C / GFRA1 / CRHR2 / SCYB14 / サイトカイン / C型肝炎 / hepatocellular carcinoma / vitaminK / ビタミンK / CagA / microarray / Mongolian gerbil infection model / intracellular signaling pathways / リン酸化 / 胃炎 / マイクロアレイ / CagPAI / cagA / マクロアレイ / スナネズミモデル / cag PAI / 細胞内情報伝達 / メタボローム / 国際情報交換アメリカ / DDX20 / microRNA122 / AFP / 肝細胞 / 分化 / 毒性学 / モデル / シミュレーション / 薬理学 / 感染症 / 個人差 / 薬剤反応性 / 生体マーカー / プロオミクス / 臨床 / プロテオミクス / 炎症 / ゲノム / 遺伝子 Less

Metabolomic analyses in microRNA-reduced HCC
- Principal Investigator
  
  KOndo Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the enhanced IFN action by the non-coding RNA and its application on HCV treatmentPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analyses about the role of DDX20 in hepatocarcinogenesis
- Principal Investigator
  
  GOTO Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analyses of liver-specific miRNA function and the development of the strategy about the efficient induction of differentiation into hepatocytes
- Principal Investigator
  
  KONDO Yuuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
A study on the effects of HBV-DNA integration on non-B non-C hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Establishment of quantitative prediction method for the individual variabilities in hematologic toxicity of anti-cancer agents
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Exhaustive Studies on Genomic Changes in Gastric Cancer and Precancerous COnditionsPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Treatment of advanced liver cancer targeting tumor and tumor-related markers
- Principal Investigator
  
  MAEDA Shin, OMATA Masao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analyses of the individual risk for hepatocellular carcinoma by large scale search of single nucleotide polymorphisms of cytokine genes
- Principal Investigator
  
  KATO Naoya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo Hospital
Analyses of molecular mechanisms of hepatocellular carcinoma cell growth suppression induced by vitamin K
- Principal Investigator
  
  TERATANI Takuma
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Molecular Biological Studies on Cellular Proliferation and Apoptosis Induced by H. pyloriPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Identification and validation of novel virulence factors of Helicobacter pyloriPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
The molecular mechanism of te pathogenesis induced by Helicbacter phylori (TN2) and the clinical application
- Principal Investigator
  
  OMATA Masao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Cloning of human proteins which interact with heaptitis C virus proteinsPrincipal Investigator
- Principal Investigator
  
  YOSHI Haruhiko, 丹羽泰郎
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Classification of VacA,a cytotoxin produced by Helicobacter pylori, based on gene analyzesPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo

[Book] 肝胆膵エキズパートマニュアル2008
- Author(s)
  小俣政男、伊佐山浩通、吉田晴彦、椎名秀一朗
- Total Pages
  441
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.2015
- Author(s)
  Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  World J Hepatol.
  
  Volume: 27 Issue: 1 Pages: 1-6
- DOI
  10.4254/wjh.v7.i1.1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979, KAKENHI-PROJECT-26860492
[Journal Article] Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.2015
- Author(s)
  Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  World J Hepatol.
  
  Volume: 7 Pages: 1-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 8339-52
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460979
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.2014
- Author(s)
  Shibata C, Ohno M, Otsuka M, Kishikawa T, Goto K, Muroyama R, Kato N, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  Virology
  
  Volume: 462-463 Pages: 42-48
- DOI
  10.1016/j.virol.2014.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390184, KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979
[Journal Article] Perihepatic lymph node enlargement is a negative predictor for sustained responses to pegylated interferon-α and ribavirin therapy for Japanese patients infected with hepatitis C virus genotype 1.2013
- Author(s)
  Yoshida H et al. (16人中4番目)
- Journal Title
  
  Hepatol Res.
  
  Volume: Epub Issue: 10 Pages: 1005-1012
- DOI
  10.1111/hepr.12061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression.2013
- Author(s)
  Shibata C, Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Yoshida H, Koike K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 438(1) Issue: 1 Pages: 230-5
- DOI
  10.1016/j.bbrc.2013.07.064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076
[Journal Article] Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.2013
- Author(s)
  Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K.
- Journal Title
  
  PLoS One.
  
  Volume: 8(9) Issue: 9 Pages: e71969-e71969
- DOI
  10.1371/journal.pone.0071969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25860520
[Journal Article] Meta-analysis: mortality and serious adverse events of peginterferon plus ribavirin therapy for chronic hepatitis C.2013
- Author(s)
  Yoshida H et al. (6人中5番目)
- Journal Title
  
  J Gastroenterol.
  
  Volume: 48 Issue: 2 Pages: 254-68
- DOI
  10.1007/s00535-012-0631-y
- NAID
  10031156311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients : a randomized controlled trial2013
- Author(s)
  Ohki T, Tateishi R, Akahane M, Mikami S, Sato M, Uchino K, Arano T, Enooku K, Kondo Y, Yamashiki N, Goto T, Shiina S, Yoshida H, Matsuyama Y, Omata M, Ohtomo K, Koike K
- Journal Title
  
  Am JGastroenterol
  
  Volume: 108(8) Issue: 8 Pages: 1305-13
- DOI
  10.1038/ajg.2013.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590962, KAKENHI-PROJECT-25460979
[Journal Article] Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs.2013
- Author(s)
  Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Takata A, Shibata C, Kondo Y, Akanuma M, Yoshida H, Koike K.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 2739-2739
- DOI
  10.1038/srep02739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979
[Journal Article] A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function.2012
- Author(s)
  Otsuka M et al. (8人中2番目)
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 420 Issue: 3 Pages: 564-9
- DOI
  10.1016/j.bbrc.2012.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23590960
[Journal Article] Silencing of microRNA-122 enhances interferon- α signaling in the liver through regulating SOCS3 promoter methylation2012
- Author(s)
  Otsuka M
- Journal Title
  
  Sci Rep
  
  Volume: 2 Issue: 1 Pages: 637-637
- DOI
  10.1038/srep00637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-24590956
[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma : impact on patient's prognosis.2011
- Author(s)
  Koncro Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
- Journal Title
  
  Liver Int.
  
  Volume: (In press)(掲載確定) Pages: 197-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators2011
- Author(s)
  Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H, Koike K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 411(4) Issue: 4 Pages: 826-31
- DOI
  10.1016/j.bbrc.2011.07.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590960
[Journal Article] MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K
- Journal Title
  
  Nat Commun.
  
  Volume: 2 Issue: 1 Pages: 338-338
- DOI
  10.1038/ncomms1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-22590718
[Journal Article] MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H,Omata M, Nepveu A, Koike K.
- Journal Title
  
  Nat Commun
  
  Volume: 2 Pages: 338-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] Intrahepatic bile ductdilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011
- Author(s)
  Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
- Journal Title
  
  Liver Int
  
  Volume: 31 Pages: 197-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients.2011
- Author(s)
  Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
- Journal Title
  
  Int J Cancer.
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] A phise I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma.2011
- Author(s)
  Kanai F, Yoshida H, Tateishi R, Sato S, Kawabe T, Obi S, Kondo Y, Taniguchi M, Tagawa K, Ikeda M, Morizane C, Okusaka T, Arioka H, Shiina S, Omata M.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: (In press)(掲載確定) Pages: 315-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS 13 in chronic hepatitis B and C2011
- Author(s)
  Ikeda H, Tateishi R, Enooku K, Yoshida H, nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev.
  
  Volume: 20 Issue: 10 Pages: 2204-11
- DOI
  10.1158/1055-9965.epi-11-0464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718, KAKENHI-PROJECT-23590960, KAKENHI-PROJECT-23590962
[Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation2011
- Author(s)
  Goto T, Yoshida H, 他10名
- Journal Title
  
  Hepatology International
  
  Volume: (Published Online,掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Influence of anti-HBc seropositivity on the risk of hepatocellular carcinoma in HCV-infected patients after adjusting for confounding factors.2010
- Author(s)
  Ohki T, Goto T, Yoshida H, 他10名
- Journal Title
  
  Journal of Viral Hepatitis 17
  
  Pages: 91-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Influence of HBcAb seropositivity on the risk of hepatocellular carcinoma in HCV infected patients.2010
- Author(s)
  Ohki T, Tateishi R, Goto E, Sato T, Masuzaki R, Imamura J, Goto T, Kanai F, Shiina S, Yoshida H, Kawabe T, Omata M
- Journal Title
  
  J Viral Hepatitis. 17
  
  Pages: 91-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment inpatients with suspected NASH.2009
- Author(s)
  Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M
- Journal Title
  
  Gut 58
  
  Pages: 839-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Percutaneous radiofrequency ablation of hepatocellular carcinoma in 14 patients undergoing regular hemodialysis for end-stage renal disease.2009
- Author(s)
  Kondo Y, Yoshida H, Tomizawa Y, Tateishi R, Shiina S, Tagawa K, Omata M.
- Journal Title
  
  Am J Roentgenol 193
  
  Pages: 964-969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Visceral fat accumulation is an independent risk factor for hepatocellular carcinoma recurrence after curative treatment in patients with suspected NASH.2009
- Author(s)
  Ohki T, Tateishi R, Shiina S, Goto E, Sato T, Nakagawa H, Masuzaki R, Goto T, Hamamura K, Kanai F, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Gut 58
  
  Pages: 839-844
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography.2009
- Author(s)
  Masuzaki R, Tateishi R, Yoshida H, Goto E, Sato T, Ohki T, Imamura J, Goto T, Kanai F, Kato N, Ikeda H, Shiina S, Kawabe T, Omata M.
- Journal Title
  
  Hepatology 49
  
  Pages: 1954-1961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences.2009
- Author(s)
  Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, Shiina S, Omata M.
- Journal Title
  
  Int J Cancer 125
  
  Pages: 2264-2269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients2008
- Author(s)
  Li Y, Tanaka Y, Tada M, Hua R, Seto M, Asaoka Y, Ohta M, Kanai F, Yoshida H, Kawabe T, Sano T, Motojima T, Yokosuka O, Omata M.
- Journal Title
  
  APMIS 116
  
  Pages: 931-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] The effect of Helicobacter pylori eradication on reducing the incidence of gastric cancer.2008
- Author(s)
  Ogura K, Yoshida H, 他11名
- Journal Title
  
  Journal of Clinical Gastroenterology 42
  
  Pages: 279-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590669
[Journal Article] Obesity is an independent risk factor for hepatocellular carcinoma2008
- Author(s)
  Ohki T, Goto T, Yoshida H 他11名
- Journal Title
  
  Clinical Gastroenterology and Hepatology 6
  
  Pages: 459-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Risk assessment of hepatocellular carcinoma in chronic hepatitis C patients by transient elastography2008
- Author(s)
  Masuzaki R, Yoshida H 他10名
- Journal Title
  
  Journal of Clinical Gastroenterology 42
  
  Pages: 839-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] 「NASH由来肝癌はわが国に存在するか」わが国のNASH関連肝癌発生率を推定する2008
- Author(s)
  吉田晴彦、五藤忠他7名
- Journal Title
  
  日本消化器病学会雑誌 105
  
  Pages: 1577-1583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Inhibitory effects of terpenoids on multidrug resistance-associated protein 2-and breast cancer resistance protein-mediated transport2008
- Author(s)
  Naoko Yoshida, 他
- Journal Title
  
  Drug Metab Dispos
- Data Source
  KAKENHI-PROJECT-19390039
[Journal Article] Rapid detection of the hepatitis B virus YMDD mutant using TaqMan-minor groove binder probes2008
- Author(s)
  Hua R, Tanaka Y, Fukai K, Tada M, Seto M, Asaoka Y, Ohta M, Goto T, Kanai F, Kato N, Yoshida H, Kawabe T, Yokosuka O, Omata M.
- Journal Title
  
  Clin Chim Acta 395
  
  Pages: 151-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Assessing liver tumor stiffness by transient elastography2007
- Author(s)
  Masuzaki R, Tateishi R, Yoshida H, Sato T, Ohki T, Goto T, Yoshida H, Sato S, Sugioka Y, Ikeda H, Shiina S, Kawabe T, Omata M.
- Journal Title
  
  Hepatol Int 1
  
  Pages: 394-397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Local ablation therapy for hepatocellular carcinoma. From ethanol injection to radiofrequency ablation2007
- Author(s)
  Shiina S, Tateishi R, Yoshida H, Kanai F, Omata M.
- Journal Title
  
  Saudi Med J 28
  
  Pages: 831-837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma2006
- Author(s)
  Muroyama R, Kato N, Yoshida H, Otsuka M, Moriyama M, Wang Y, Shao RX, Dharel N, Tanaka Y, Ohta M, Tateishi R, Shiina S, Tatsukawa M, Fukai K, Imazeki F, Yokosuka O, Shiratori Y, Omata M.
- Journal Title
  
  J Hepatol 45
  
  Pages: 805-812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations2006
- Author(s)
  Teratani T, Yoshida H, Shiina S, Obi S, Sato S, Tateishi R, Mine N, Kondo Y, Kawabe T, Omata M.
- Journal Title
  
  Hepatology 43
  
  Pages: 1101-1108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors2006
- Author(s)
  Tateishi K, Ohta M, Guleng B, Kanai F, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Imamura T, Ijichi H, Ikenoue T, Kawakami T, Fukushima Y, Washida M, Sata M, Miyagishi M, Taira K, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Int J Cancer 118
  
  Pages: 2237-2246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016016
[Journal Article] Hepatitis C virus core protein and hepatitis activity are associated through transactivation of interleukin-8.2005
- Author(s)
  Hoshida Y, Kato N, Yoshida H, Wang Y, Tanaka M, Goto T, Otsuka M, Taniguchi H, Moriyama M, Imazeki F, Yokosuka O, Kawabe T, Shiratori Y, Omata M.
- Journal Title
  
  J Infect Dis 192
  
  Pages: 266-275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Proposal of a new prognostic model for hepatocellular carcinoma : an analysis of 403 patients.2005
- Author(s)
  Tateishi R, Yoshida H, Shiina S, Imamura H, Hasegawa K, Teratani T, Obi S, Sato S, Koike Y, Fujishima T, Makuuchi M, Omata M.
- Journal Title
  
  Gut 54(3)
  
  Pages: 419-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Proposal of a new prognostic model for hepatocellular carcinoma : an analysis of 403 patients.2005
- Author(s)
  Tateishi R, Yoshida H, Shiina S, Imamura H, hasegawa K, Teratani T, Obi S, Sato S, Koike Y, Fujishima T, Makuuchi M, Omata M.
- Journal Title
  
  Gut 54(3)
  
  Pages: 419-425
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Hepatitis C virus core protein upregulates transforming growth factor-β1 transcription.2004
- Author(s)
  Taniguchi H, Kato N, Otsuka M, Goto T, Yoshida H, Shiratori Y, Omata M.
- Journal Title
  
  J Med Virol 72
  
  Pages: 52-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590578
[Journal Article] Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein--a retrospective analysis using 952 consecutive HCC patients2003
- Author(s)
  Koike Y, Nakagawa K, Shiratori Y, Shiina S, Imamura M, Sato S, Obi S, Teratani T, Hamamura K, Yoshida H, Omata M.
- Journal Title
  
  Hepatogastroenterology 50(54)
  
  Pages: 2035-2039
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Percutaneous radiofrequency ablation for hepatocellular carcinoma
- Author(s)
  Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike Y, Fujishima T, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Cancer (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Percutaneous radiofrequency ablation for hepatocellular carcinoma.
- Author(s)
  Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike Y, Fujishima T, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Cancer (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Serum level of adiponectin and the risk of liver cancer development.
- Author(s)
  Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K
- Journal Title
  
  Int J Cancer Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Journal Article] Percutaneous radiofrequency ablation for hepatocellular carcinoma.
- Author(s)
  Tateishi R, Shiina S, Teratani T, Obi S, Sato S, Koike Y, Fujishima T, Yoshida H, Kawabe T, Omata M.
- Journal Title
  
  Cancer (印刷中)
- Data Source
  KAKENHI-PROJECT-15590620
[Journal Article] Influence of serum HBV DNA load on recurrence of hepatocellular carcinoma after treatment with percutaneous radiofrequency ablation.
- Author(s)
  Goto T, Yoshida H, Tateishi R, Enooku K, Goto E, Sato T, Ohki T, Masuzaki R, Imamura J, Shiina S, Koike K, Omata M
- Journal Title
  
  Hepatol Int
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] RISK FACTORS FOR HEPATOCARCINOGENESIS IN NON-VIRAL, NO N-ALCOHOLIC HEPATITIS AND CIRRHOSIS2011
- Author(s)
  Enooku K, Yoshida H, 他12名
- Organizer
  EASL2011
- Place of Presentation
  ベルリン、ドイツ
- Year and Date
  2011-04-01
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] 脂肪肝の消失は発癌のリスクファクターである2010
- Author(s)
  榎奥健一郎、建石良介、新野徹、内野康志、後藤絵里子、中川隼人、増崎亮太、近藤祐嗣、五藤忠、椎名秀一朗、吉田晴彦、小池和彦
- Organizer
  JDDW2010
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] microRNA machinery構成因子DDX20の発現低下に伴うmicroRNA機能の減弱によって惹起される肝発癌経路の同定2010
- Author(s)
  大塚基之、高田朱弥、小島健太郎、前田愼、立石敬介、池上恒雄、平田善裕、建石良介、椎名秀一朗、吉田晴彦、小池和彦
- Organizer
  第47回日本臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590960
[Presentation] Serum IL-6 levels and the risk of hepatocarcinogenesis in chronic hepatitis C patients2009
- Author(s)
  Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, Shiina S, Omata M.
- Organizer
  DDW 2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-17016016
[Presentation] Diagnosis of intrahepatic metastasis and multicentric carcinogenesis in the patients with hepatocellular carcinoma by Loss of heterozygosity analysis using taqman SNP genotyping assays2009
- Author(s)
  Asaoka Y, Tanaka Y, Nakagawa H, Masuzaki R, Tada M, Tateishi R, Ijichi H, Ikenoue T, Maeda S, Yoshida H, Kawabe T, Omata M.
- Organizer
  DDW
- Place of Presentation
  Chicago
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-17016016
[Presentation] Taqmanプローブを用いたLOH解析による再発肝癌のクロナリティーに関する検討2009
- Author(s)
  浅岡良成、田中康雄、中川勇人、増崎亮太、多田素久、建石良介、伊地知秀明、池上恒雄、前田愼、吉田晴彦、小俣政男
- Organizer
  JDDW 2009
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-17016016
[Presentation] Visceral fat accumulation is an independent risk factor f hepatcellular carcinoma recurrence after curative treatment in NASH suspected patients.2008
- Author(s)
  大木隆正, 建石良介, 椎名秀一朗, 後藤絵里子, 佐藤隆久, 増崎亮太, 五藤忠, 浜村啓介, 金井文彦, 吉田英雄, 川辺隆夫, 小俣政男
- Organizer
  59th AASLD Annual Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] 肝臓癌及び消化器癌の日本人患者におけるAKT1のpleckstrinホモロジードメイン変異の欠落2008
- Author(s)
  Li Y、田中康雄、多田素久、華瑞、瀬戸元子、浅岡良成、大田幹、金井文彦、吉田晴彦、川邊隆夫、横須賀収、小俣政男
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  愛媛
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-17016016
[Presentation] NASHと肝細胞癌非B非C肝癌の特徴と予後2008
- Author(s)
  大木隆正、建石良介、後藤絵里子、佐藤隆久、増崎亮太、五藤忠、浜村啓介、吉田英雄、金井文彦、椎名秀一朗、吉田晴彦、川辺隆夫、小俣政男
- Organizer
  第44回日本肝癌研究会
- Place of Presentation
  大阪
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] HBc抗体陽性はC型慢性肝炎患者の肝発癌に影響を与えない2008
- Author(s)
  大木隆正、建石良介、後藤絵里子、佐藤隆久、増崎亮太、五藤忠、浜村啓介、吉田英雄、金井文彦、加藤直也、椎名秀一朗、吉田晴彦、川辺隆夫、小俣政男
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] Visceral fat accumulation is an independent risk factor of hepatocellular carcinoma recurrence after curative treatment in NASH suspected patients.2008
- Author(s)
  Ohki T, Goto T, Yoshida H他
- Organizer
  AASLD 2008
- Place of Presentation
  Los Angeles
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20590762
[Presentation] 高密度オリゴヌクレオチドアレイから抽出した遺伝子を用いた肝癌臨床検体のコピー数解析2007
- Author(s)
  田中康雄、金井文彦、多田素久、建石良介、浅岡良成、瀬戸元子、大田幹、立石敬介、椎名秀一朗、吉田晴彦、川邊隆夫、横須賀収、小俣政男
- Organizer
  JDDW
- Place of Presentation
  神戸
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-17016016
[Presentation] INHIBITION OF BREAST CANCER RESISTANCE PROTEIN (BCRP)-MEDIATED TRANSPORT BY TERPENOIDS2007
- Author(s)
  Naoko Yoshida, 他
- Organizer
  Pharmaceutical sciences world congress(PSWC 2007)
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-19390039
[]
[]
[]
[]
[]

1. OTSUKA Motoyuki (90518945)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. KATO Naoya (90313220)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. OMATA Masao (90125914)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. SHIRATORI Yasushi (70196624)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KONDO Yuuji (00572231)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. KANAI Fumihiko (70334399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. TATEISHI Keisuke (20396948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
8. KANDA Yoshinobu (30334379)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. GOTO Tadashi (40444088)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
10. MAEDA Shin (40415956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. ENOMOTO Nobuyuki (20251530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SASAKI Shigeru (10305229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANAKA Yasuo (40422290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
14. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ITO Kousei (30323405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HISAKA Akihiro (80420206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TERATANI Takuma (30359616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. KAWAKAMI Takayuki (60376457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 丹羽泰郎 (20282668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NAKAO Masafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OGURA Keiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MITSUNO Yuzo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 椎名秀一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIDA Haruhiko 吉田 晴彦

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Elucidation of the enhanced IFN action by the non-coding RNA and its application on HCV treatmentPrincipal Investigator

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A study on the effects of HBV-DNA integration on non-B non-C hepatocellular carcinomaPrincipal Investigator

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Exhaustive Studies on Genomic Changes in Gastric Cancer and Precancerous COnditionsPrincipal Investigator

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Molecular Biological Studies on Cellular Proliferation and Apoptosis Induced by H. pyloriPrincipal Investigator

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Identification and validation of novel virulence factors of Helicobacter pyloriPrincipal Investigator

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Cloning of human proteins which interact with heaptitis C virus proteinsPrincipal Investigator

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YOSHIDA Haruhiko 吉田晴彦