Okubo Minoru 大久保実

… Alternative Names

大久保実オオクボミノル

OKUBO Minoru 大久保実

MINORU Okubo 大久保実

Less

Researcher Number	60241238
Affiliation (Current)	2025: (財)冲中記念成人病研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2019: (財)冲中記念成人病研究所, その他部局等, 研究員 2012 – 2014: 公益財団法人冲中記念成人病研究所, その他部局等, 研究員 2007: Okinaka Memorial Institute for Medical Research, Investigator 2005 – 2006: (財)冲中記念成人病研究所, 研究員 2002 – 2003: 財団法人冲中記念成人病研究所, 研究員 … More 2001: 冲中記念成人病研究所, 研究員 2000: (財)冲中記念成人病研究所, 研究員 2000: Okinaka Memorial Institute for Medical Research, Research Fellow, 研究員 1999: 財団法人冲中記念成人病研究所, 研究員 1996: (財)冲中記念成人病研究所, 研究員 1995: 財団法人冲中記念成人病研究所, 研究員 1994: (財)冲中記念成人病研究所, 研究員 1993: (財)〓中記念成人病研究所, 研究員 1993: 冲中記念成人病研究所, 研究員 1992: 財団法人冲中記念成人病研究所, 研究員 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Pediatrics / Pediatrics / Metabolomics Except Principal Investigator 内科学一般
Keywords	Principal Investigator AGL / グリコーゲン / HL / LPL / Glycogen debranching enzyme / 遺伝子変異 / 脱分枝酵素 / 糖原病III型 / 糖原病 / 遺伝子解析 … More / 遺伝子 / スプライシング / 遺伝・先天異常学 / atherosclerosis / metabolic syndrome / linids / internal medicine / genetics / メタボリック・シンドローム / 動脈硬化 / LRP5 / 代謝症候群 / 脂質 / 内科 / 遺伝学 / Ethnic groups / Glycogen / Genetic mutation / Glycogen storage disease / スプライシング変異 / ナンセンス変異 / グリコーゲン脱分枝酵素 / ハプロタイプ / 糟原病III型 / エスニックグループ / Glycogen-binding domain / Mutation / Glycogen storage disease type III / 組織特異的発現 / グリコーゲン結合部位 / キャリアー / 点変異 / glucose-6-phosphatase / 糖原病I型 / von Gierke病 / ミスセンス変異 / 低HDLコレステロール血症 / LCAT欠損症 / 一塩基置換 / III型高脂血症 / アポ蛋白E / 高中性脂肪血症 / アポ蛋白CII … More Except Principal Investigator LDL receptor / HLA antigen / Blood coagulation-fibrinolysis / Lipoprotein (a) / HDL-cholesterol / Serum cholesterol values / Coronary artery sclerosis / Familial hypercholesterolemia / 家族性高コレステロ-ル血症 / LDLレセプター遺伝子変異 / Lp(a) / 冠動脈硬化 / LDLレセプター / HLA抗原 / 凝固線溶系分子マーカー / 高Lp(a)血症 / HDL-コレステロール / 血清コレステロール値 / 冠動脈硬化症 / 家族性高コレステロール血症 Less

For a treatment of glycogen storage disease type III by controlling glycogen accumulationPrincipal Investigator
- Principal Investigator
  
  Okubo Minoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okinaka Memorial Institute for Medical Research
Analysis on new mechanisms causing abnormal glycogenolysisPrincipal Investigator
- Principal Investigator
  
  OKUBO Minoru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okinaka Memorial Institute for Medical Research
Molecular genetic studies on metabolic syndromePrincipal Investigator
- Principal Investigator
  
  MINORU Okubo
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Okinaka Memorial Institute for Medical Research
Study on genetic mutations and their functions in glycogen storage disease type IIIPrincipal Investigator
- Principal Investigator
  
  OKUBO Minoru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okinaka Memorial Institute for Medical Research
Study on genetic diagnosis for glycogen storage disease type III and relationship between enzymatic activities and clinical manifestationsPrincipal Investigator
- Principal Investigator
  
  OKUBO Minoru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Okinaka Memorial Institute for Medical Research
von Gierke病患者の遺伝子解析Principal Investigator
- Principal Investigator
  
  大久保実
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okinaka Memorial Institute for Medical Research
家族性LCAT欠損症の遺伝子解析Principal Investigator
- Principal Investigator
  
  大久保実
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okinaka Memorial Institute for Medical Research
家族性III型高脂血症を惹起するアポリポ蛋白E2変異体の遺伝子解析Principal Investigator
- Principal Investigator
  
  大久保実
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okinaka Memorial Institute for Medical Research
アポ蛋白CII欠損症患者の遺伝子解析Principal Investigator
- Principal Investigator
  
  大久保実
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Okinaka Memorial Institute for Medical Research
Studies on the susceptibility to coronary artery sclerosis in patients with familial hypercholesterolemia
- Principal Investigator
  
  MURASE Toshio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Okinaka Memorial Institute for Medical Research

All 2020 2015 2013 2012 2008 2007

All Journal Article Book

[Book] 新臨床内科学　［デスク判］第10版（矢﨑義雄、監修）第６章代謝・栄養疾患 6. 先天性糖質代謝異常症 (p760-768)2020
- Author(s)
  大久保　実
- Total Pages
  9
- Publisher
  医学書院
- ISBN
  9784260038065
- Data Source
  KAKENHI-PROJECT-17K10066
[Book] Chylomicronemia(including type III hyperlipoproteinemia)2008
- Author(s)
  Okubo M
- Publisher
  Hormone to Rinsyo Igaku no Sekai sya, Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590951
[Book] 脂質代謝異常症診療の新展開(ホルモンと臨床、56巻3号)2008
- Author(s)
  大久保実
- Total Pages
  10
- Publisher
  医学の世界社(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590951
[Book] メタボリックシンドローム概論(加藤規弘編)2007
- Author(s)
  大久保実
- Publisher
  メヂカルフレンド社
- Data Source
  KAKENHI-PROJECT-17590951
[Book] メタボリックシンドローム概論(加藤規弘編)2007
- Author(s)
  大久保実
- Publisher
  メヂカルフレンド社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590951
[Journal Article] Molecular and clinical delineation of 12 patients with glycogen storage disease type III in Western Turkey2015
- Author(s)
  Okubo M, Kalkan Ucar S, Podskarbi T, Murase T, Shin YS, Coker M
- Journal Title
  
  Clin Chim Acta
  
  Volume: 439 Pages: 162-167
- DOI
  10.1016/j.cca.2014.10.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591534
[Journal Article] A founder AGL mutation causing glycogen storage disease type IIIa in Inuit identified through whole-exome sequencing: a case series.2015
- Author(s)
  Rousseau-Nepton I, Okubo M, Grabs R, FORGE Canada Consortium, Mitchell J, Polychronakos C, Rodd C
- Journal Title
  
  CMAJ
  
  Volume: 187 Issue: 2 Pages: E68-E73
- DOI
  10.1503/cmaj.140840
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591534
[Journal Article] Liver cirrhosis treated by living donor liver transplantation in a patient with AGL mutation c.2607-2610delATTC and c.1672dupA.2013
- Author(s)
  Kondo Y, Usui H, Ishige-Wada M, Murase T, Owada M, Okubo M
- Journal Title
  
  Clin Chim Acta
  
  Volume: 印刷中 Pages: 19-21
- DOI
  10.1016/j.cca.2013.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591534
[Journal Article] 糖原病III型2012
- Author(s)
  大久保　実
- Journal Title
  
  日本臨牀
  
  Volume: 新領域別症候群シリーズ19 Pages: 47-50
- Data Source
  KAKENHI-PROJECT-24591534
[Journal Article] A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency2007
- Author(s)
  Okubo M, et. al.
- Journal Title
  
  Molecular Genetics and Metabolism 92
  
  Pages: 229-233
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590951
[Journal Article] A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency2007
- Author(s)
  Okubo M, et. al.
- Journal Title
  
  Molecular Genetics and Metabolism peer-reviewed 92
  
  Pages: 229-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590951
[Journal Article] Lipid metabolism in metabolic syndrome2007
- Author(s)
  Okubo M
- Journal Title
  
  Metabolic syndrome(Kato N, editor) Medical friend, Co., Tokyo
  
  Pages: 58-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590951

1. MURASE Toshio (60107612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TSUKADA Masayasu (90072595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KOBAYASHI Tetsuro (30113442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. EBARA Tetsu (40307004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SIKI Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Okubo Minoru 大久保 実

大久保 実 オオクボ ミノル

OKUBO Minoru 大久保 実

MINORU Okubo 大久保 実

Research Projects

Research Products

Co-Researchers

For a treatment of glycogen storage disease type III by controlling glycogen accumulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis on new mechanisms causing abnormal glycogenolysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular genetic studies on metabolic syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on genetic mutations and their functions in glycogen storage disease type IIIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on genetic diagnosis for glycogen storage disease type III and relationship between enzymatic activities and clinical manifestationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

von Gierke病患者の遺伝子解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

家族性LCAT欠損症の遺伝子解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

家族性III型高脂血症を惹起するアポリポ蛋白E2変異体の遺伝子解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アポ蛋白CII欠損症患者の遺伝子解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the susceptibility to coronary artery sclerosis in patients with familial hypercholesterolemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新臨床内科学 ［デスク判］ 第10版 （矢﨑義雄、監修）第６章 代謝・栄養疾患 6. 先天性糖質代謝異常症 (p760-768)2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Chylomicronemia(including type III hyperlipoproteinemia)2008

Author(s)

Publisher

Description

Data Source

[Book] 脂質代謝異常症診療の新展開(ホルモンと臨床、56巻3号)2008

Author(s)

Okubo Minoru 大久保実

大久保実オオクボミノル

OKUBO Minoru 大久保実

MINORU Okubo 大久保実

[Book] 新臨床内科学　［デスク判］第10版（矢﨑義雄、監修）第６章代謝・栄養疾患 6. 先天性糖質代謝異常症 (p760-768)2020

[Book] メタボリックシンドローム概論(加藤規弘編)2007