ATSUSHI Sugiyama 杉山篤

… Alternative Names

杉山篤スギヤマアツシ

SUGIYAMA Atsushi 杉山篤

Less

Researcher Number	60242632
Other IDs
Affiliation (Current)	2025: 東邦大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 東邦大学, 医学部, 教授 2010 – 2018: 東邦大学, 医学部, 教授 2007 – 2008: 山梨大学, 医学工学総合研究部, 准教授 2006: University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Associate Professor, 大学院医学工学総合研究部, 助教授 2003 – 2005: 山梨大学, 大学院・医学工学総合研究部, 助教授 1996 – 1998: 山梨医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Basic Section 55060:Emergency medicine-related Except Principal Investigator Cardiovascular surgery / General pharmacology / Cardiovascular medicine / Applied pharmacology
Keywords	Principal Investigator 完全房室ブロック / 致死性不整脈 / torsades de pointes / QT延長 / 心房細動 / 電気薬理学 / 蘇生 / 薬物治療 / 低体温療法 / torsade de pointes … More / QT間隔延長 / 薬物治療戦略 / 低体温 / 充満期拡張能 / 左室等容性弛緩能 / 拡張性心不全 / 左室圧容積関係 / EP4受容体刺激 / 慢性房室ブロック犬 / HFrEF / HFpEF / Caldaret / SERCA / 細胞内Ca2+ / EP4受容体 / caldaret / ONO-AE1-329 / 収縮不全型心不全 / 拡張不全型心不全 / upstream / candesartan / amiodarone / atrioventricular block / atrial fibrillation / ANP / MRI / カテーテルアブレーション法 / うっ血性心不全 / アンジオテンシンII / 発作性心房細動モデル犬 / アップストリーム治療薬 / アップストリーム / カンデサルタン / アミオダロン / Complete AV block / Safety Pharmacology / Drug / Lathal arrhythmias / Long QT syndrome / 慢性房室ブロック犬モデル / 安全域 / 多型性心室頻拍 / ホルター心電図 / 徐脈 / 安全性薬理学 / 薬物 / QT延長症候群 / 房室ブロック / 房室結節ブロック / fingolimod / スフィンゴシン1-リン / Giタンパク / 房室伝導ブロック / フィンゴリモド / スフィンゴシン1-リン酸 / Buchmann束 / 抗不整脈薬 / 血液 / 心血管 / phosphodiesterase活性 / 真空凍結乾燥 / 房室結節 / Phosphodiesterase活性 / 刺激伝導系 / cyclicAMP / 単相性活動電位 / 不整脈 / 激発活動 … More Except Principal Investigator プログラム電気刺激 / 致死的不整脈 / 心筋疾患外科学 / マイクロミニピッグ / ホルター心電図 / 致死性不整脈 / 重症心不全 / 心筋梗塞 / iPS細胞 / ミトコンドリア機能 / QT間隔延長 / 左室拡張不全 / 心臓毒性 / ハロセン麻酔犬 / 慢性房室ブロック犬モデル / 心毒性 / Lapatinib / Onco-cardiology / 経胸壁心臓超音波検査 / 慢性房室ブロックモデル / ハロセン麻酔犬モデル / ラパチニブ / 心循環器毒性 / Onco-Cardiology / がん分子標的薬 / 安全性薬理 / 腎デナベーション / 交感神経 / 高血圧 / アップストリーム治療 / 薬物治療戦略 / 心筋再分極異常 / N型Ca^<2+>チャネル / 薬物治療 / 心臓突然死 / QT延長症候群 Less

Exploring drug treatment strategies to avoid the occurrence of lethal arrhythmias associated with therapeutic hypothermiaPrincipal Investigator
- Principal Investigator
  
  杉山篤
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Toho University
Effects of EP4 receptor agonist on the left ventricular diastolic function, and analysis of its mechanismPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Atsushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
Estabrishment of non-clinical evaluating models in cardiotoxicities induced by a melecular targeted EGFR inhibitor for cancer
- Principal Investigator
  
  Kentaro Ando
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Chiba Institute of Science
  Toho University
Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy
- Principal Investigator
  
  Sakaguchi Hisashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Kyoto University
Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolomod-induced atrioventricular conduction blockPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
RENAL DENERVATION: NOVEL THERAPY FOR RESISTANT HYPERTENSION
- Principal Investigator
  
  Sato Akira
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  University of Tsukuba
Identification of therapeutic target molecules againstatrial fibrillation: Use of the canine persistent atrial fibrillation modelPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Atsushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
PHARMACOTHERAPEUTIC STRATEGY FOR PREVENTION OF CARDIAC SUDDEN DEATH CAUSED BY VENTRICULAR REPOLARIZATION ABNORMALITY
- Principal Investigator
  
  TAKAHARA Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Toho University
Search of upstream drugs for treatment of atrial fibrillation using a new canine atrial fibrillation modelPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Yamanashi
Dangerous QT prolongation can be assayed by using the chronic atrioventricular block dogPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Atsushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Yamanashi
刺激伝導系におけるphosphodiesterase活性の測定Principal Investigator
- Principal Investigator
  
  杉山篤
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  山梨医科大学
イヌ心室性激発活動誘発不整脈モデルの開発Principal Investigator
- Principal Investigator
  
  杉山篤
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  山梨医科大学

[Book] 図解薬害・副作用学 (みてわかる薬学)2023
- Author(s)
  杉山篤, 神林隆一
- Total Pages
  612
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-23K08430
[Book] 動物の心電図・心エコー・血圧・病理学検査　増補改訂版2013
- Author(s)
  杉山篤, 中村裕二
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Analysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs2024
- Author(s)
  Goto A, Kambayashi R, Fujishiro M, Hasegawa C, Izumi-Nakaseko H, Takei Y, Kurosaki K, Sugiyama
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 未定
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08430
[Journal Article] Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir2024
- Author(s)
  Goto Ai、Kambayashi Ryuichi、Chiba Koki、Shinozaki Makoto、Moritani Kiryu、Izumi-Nakaseko Hiroko、Takei Yoshinori、Hirasawa Akira、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 4 Pages: 294-300
- DOI
  10.1016/j.jphs.2024.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15143, KAKENHI-PROJECT-23K08430
[Journal Article] Characterization of cardiovascular profile of anti-influenza drug peramivir: A reverse-translational study using the isoflurane-anesthetized dog2024
- Author(s)
  Kambayashi Ryuichi、Goto Ai、Izumi-Nakaseko Hiroko、Takei Yoshinori、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 154 Issue: 3 Pages: 218-224
- DOI
  10.1016/j.jphs.2024.02.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15143, KAKENHI-PROJECT-23K08430
[Journal Article] Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study2023
- Author(s)
  Suzuki Nobuyuki、Kambayashi Ryuichi、Goto Ai、Izumi-Nakaseko Hiroko、Takei Yoshinori、Naito Atsuhiko T、Sugiyama Atsushi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 12 Pages: 645-654
- DOI
  10.2131/jts.48.645
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15143, KAKENHI-PROJECT-23K08430
[Journal Article] Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations.2023
- Author(s)
  Goto Ai, Kambayashi Ryuichi, Izumi-Nakaseko Hiroko, Shinozaki Makoto, Takei Yoshinori, Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: － Issue: 4 Pages: 201-209
- DOI
  10.1016/j.jphs.2023.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16136, KAKENHI-PROJECT-23K15143, KAKENHI-PROJECT-23K08430
[Journal Article] Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs2019
- Author(s)
  Sugiyama Atsushi、Hagiwara-Nagasawa Mihoko、Kambayashi Ryuichi、Goto Ai、Chiba Koki、Ando Kentaro、Naito Atsuhiko T.、Izumi-Nakaseko Hiroko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 139 Issue: 3 Pages: 180-185
- DOI
  10.1016/j.jphs.2019.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study2018
- Author(s)
  Matsukura Suchitra、Nakamura Yuji、Hoshiai Kiyotaka、Hayashi Takashi、Koga Tadashi、Goto Ai、Chiba Koki、Lubna Nur Jaharat、Hagiwara-Nagasawa Mihoko、Izumi-Nakaseko Hiroko、Ando Kentaro、Naito Atsuhiko T.、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 136 Issue: 4 Pages: 234-241
- DOI
  10.1016/j.jphs.2018.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction2018
- Author(s)
  Wada T, Ando K, Naito AT, Nakamura Y, Goto A, Chiba K, Lubna NJ, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Nakazato Y, Sugiyama A
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: - Issue: 1 Pages: 65-75
- DOI
  10.1007/s00280-018-3593-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08246, KAKENHI-PROJECT-16K08559
[Journal Article] Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death2018
- Author(s)
  Goto Ai、Hagiwara-Nagasawa Mihoko、Izumi-Nakaseko Hiroko、Kitta Kumiko、Hoshiai Kiyotaka、Chiba Koki、Ando Kentaro、Akie Yasuki、Naito Atsuhiko T.、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 138 Issue: 3 Pages: 198-202
- DOI
  10.1016/j.jphs.2018.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs2018
- Author(s)
  Goto Ai、Nakamura Yuji、Lubna Nur Jaharat、Chiba Koki、Hagiwara-Nagasawa Mihoko、Izumi-Nakaseko Hiroko、Ando Kentaro、Naito Atsuhiko T.、Sugiyama Atsushi
- Journal Title
  
  Cardiovascular Toxicology
  
  Volume: 18 Issue: 6 Pages: 530-536
- DOI
  10.1007/s12012-018-9464-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] In vivo analysis of the anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone as a guide for safety pharmacological evaluation of antiarrhythmic drugs2018
- Author(s)
  Motokawa Y, Nakamura Y, Hagiwara-Nagasawa M, Goto A, Chiba K, Lubna NJ, Izumi-Nakaseko H, Ando K, Naito AT, Yamazaki H, Sugiyama A
- Journal Title
  
  Cardiovascular toxicology
  
  Volume: 印刷中 Issue: 3 Pages: 242-251
- DOI
  10.1007/s12012-017-9434-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir2018
- Author(s)
 Lubna Nur Jaharat、Nakamura Yuji、Hagiwara-Nagasawa Mihoko、Goto Ai、Chiba Koki、Kitta Kumiko、Izumi-Nakaseko Hiroko、Ando Kentaro、Naito Atsuhiko T.、Akie Yasuki、Sugiyama Atsushi
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 43 Issue: 8 Pages: 507-512
- DOI
 10.2131/jts.43.507
- NAID
 130007430667
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08559
[Journal Article] Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine2018
- Author(s)
  Ando K, Nakamura Y, Hagiwara-Nagasawa M, Harada H, Miyamoto H, Inamura N, Takagi K, Goto A, Chiba K, Lubnaa NJ, Izumi-Nakaseko H, Naito AT, Sugiyama A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 3 Pages: 183-192
- DOI
  10.2131/jts.43.183
- NAID
  130006507322
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Effects of Red Wine Vinegar Beverage on the Colonic Tissue of Rodents: Biochemical, Functional and Pharmacological Analyses2018
- Author(s)
  Enkhsaikhan A, Takahara A, Nakamura Y, Goto A, Chiba K, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 2 Pages: 281-284
- DOI
  10.1248/bpb.b17-00816
- NAID
  130006329266
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs2018
- Author(s)
  Ando K, Takahara A, Nakamura Y, Wada T, Chiba K, Goto A, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Hoshiai K, Akie Y, Naito AT, Sugiyama A
- Journal Title
  
  Journal of pharmacological sciences
  
  Volume: 136 Issue: 2 Pages: 86-92
- DOI
  10.1016/j.jphs.2018.01.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-15K08598
[Journal Article] Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects2018
- Author(s)
  Goto Ai、Izumi-Nakaseko Hiroko、Hagiwara-Nagasawa Mihoko、Chiba Koki、Ando Kentaro、Naito Atsuhiko T.、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 137 Issue: 2 Pages: 237-240
- DOI
  10.1016/j.jphs.2018.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers2018
- Author(s)
  Izumi-Nakaseko Hiroko、Hagiwara-Nagasawa Mihoko、Naito Atsuhiko T.、Goto Ai、Chiba Koki、Sekino Yuko、Kanda Yasunari、Sugiyama Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 137 Issue: 4 Pages: 372-378
- DOI
  10.1016/j.jphs.2018.07.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08608, KAKENHI-PROJECT-16K08559
[Journal Article] Amitriptyline may have possibility to induce Brugada syndrome rather than long QT syndrome2018
- Author(s)
  Lubna NJ, Wada T, Nakamura Y, Chiba K, Cao X, Izumi-Nakaseko H, Ando K, Naito AT, Satoh Y, Sugiyama A
- Journal Title
  
  Cardiovascular toxicology
  
  Volume: 18 Issue: 1 Pages: 91-98
- DOI
  10.1007/s12012-017-9417-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-17H07135
[Journal Article] Knocking the Chest as a “Bridge to Pacemaker”: Treatment of Bradyasystole by Percussion Pacing　― Reply ―2018
- Author(s)
  Wada Takeshi、Hagiwara-Nagasawa Mihoko、Yoshihara Katsunori、Nakazato Yuji、Lurie Keith G.、Sugiyama Atsushi
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 9 Pages: 2446-2447
- DOI
  10.1253/circj.CJ-18-0765
- NAID
  130007438962
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2018-08-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17068, KAKENHI-PROJECT-16K08559
[Journal Article] Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology2017
- Author(s)
  Matsukura S, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Yamazaki H, Sugiyama A
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 133 Issue: 2 Pages: 103-109
- DOI
  10.1016/j.jphs.2017.02.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets2017
- Author(s)
  Izumi-Nakaseko H, Kanda Y, Nakamura Y, Hagiwara-Nagasawa M, Wada T, Ando K, Naito AT, Sekino Y, Sugiyama A
- Journal Title
  
  Journal of pharmacological sciences
  
  Volume: 135 Issue: 1 Pages: 44-50
- DOI
  10.1016/j.jphs.2017.08.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-17K08608
[Journal Article] Efficacy of Precordial Percussion Pacing Assessed in a Cardiac Standstill Microminipig Model2017
- Author(s)
 Wada T, Ohara H, Nakamura Y, Cao X, Izumi-Nakaseko H, Ando K, Honda M, Yoshihara K, Nakazato Y, Lurie KG, Sugiyama A
- Journal Title
 
 Circ J
 
 Volume: 81 Issue: 8 Pages: 1137-1143
- DOI
 10.1253/circj.CJ-16-1106
- NAID
 130005859077
- ISSN
 1346-9843, 1347-4820
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-16K08559
[Journal Article] Anti-atrial fibrillatory versus proarrhythmic potentials of amiodarone: a new protocol for safety evaluation in vivo2017
- Author(s)
  Matsukura S, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A
- Journal Title
  
  Cardiovascular toxicology
  
  Volume: 17 Issue: 2 Pages: 157-163
- DOI
  10.1007/s12012-016-9369-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-17H07135
[Journal Article] Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance2017
- Author(s)
  Izumi-Nakaseko H, Nakamura Y, Wada T, Ando K, Kanda Y, Sekino Y, Sugiyama A.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 2 Pages: 183-192
- DOI
  10.2131/jts.42.183
- NAID
  130005450518
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293056, KAKENHI-PROJECT-16K08559
[Journal Article] Development of an Educational Equipment “Dock-kun" to Help School Children Master High-quality Cardiac Massage2017
- Author(s)
  Nakamura Y, Miyamoto T, Yamada M†, Goto A, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Honda M, Naito AT, Yoshihara K, Lurie KG, Sugiyama A
- Journal Title
  
  Toho Journal of Medicine
  
  Volume: 3 Issue: 4 Pages: 146-151
- DOI
  10.14994/tohojmed.2017-003
- NAID
  120006422785
- ISSN
  21891990
- URL
  https://toho.repo.nii.ac.jp/records/2002836
- Year and Date
  2017-12-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Assessment of safety margin of an antipsychotic drug haloperidol for torsade de pointes using the chronic atrioventricular block dogs2017
- Author(s)
  Izumi-Nakaseko H, Nakamura Y, Cao X, Wada T, Ando K, Sugiyama A
- Journal Title
  
  Cardiovascular toxicology
  
  Volume: 17 Issue: 3 Pages: 319-325
- DOI
  10.1007/s12012-016-9388-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies2017
- Author(s)
 Yokoyama H, Nakamura Y, Saito H, Nagayama Y, Hoshiai K, Wada T, Izumi-Nakaseko H, Ando K, Akie Y, Sugiyama A
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 42 Issue: 1 Pages: 93-101
- DOI
 10.2131/jts.42.93
- NAID
 130005286689
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-16K08559
[Journal Article] Sensitivity and reliability of halothane-anesthetized microminipigs to assess risk for drug-induced long QT syndrome2017
- Author(s)
  Cao X, Wada T, Nakamura Y, Matsukura S, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A
- Journal Title
  
  Basic & clinical pharmacology & toxicology
  
  Volume: 121 Issue: 6 Pages: 465-470
- DOI
  10.1111/bcpt.12838
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-17H07135
[Journal Article] Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs2017
- Author(s)
  Chiba K, Wada T, Nakamura Y, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Tanaka K, Naito AT, Sugiyama A
- Journal Title
  
  Journal of pharmacological sciences
  
  Volume: 134 Issue: 4 Pages: 239-246
- DOI
  10.1016/j.jphs.2017.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559, KAKENHI-PROJECT-17H07135
[Journal Article] Assessment of Pharmacological Effects of Mongolian Medicinal Plant Adonis mongolica in Guinea Pigs in vivo and in vitro2017
- Author(s)
  Izumi-Nakaseko H, Li W, Cao X, Nakamura Y, Ando K, Tanaka K, Enkhsaikhan A, Gotov C, Purevjav B, Chultemsuren Y, Nyambayar K, Dorjsuren N, Hagiwara-Nagasawa M, Naito AT, Koike K, Sugiyama A
- Journal Title
  
  Toho Journal of Medicine
  
  Volume: 3 Issue: 4 Pages: 131-141
- DOI
  10.14994/tohojmed.2017-004
- NAID
  120006422783
- ISSN
  21891990
- URL
  https://toho.repo.nii.ac.jp/records/2002834
- Year and Date
  2017-12-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs2016
- Author(s)
  Honda A, Nakamura Y, Ohara H, Cao X, Nomura H, Katagi J, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 775 Pages: 130-137
- DOI
  10.1016/j.ejphar.2016.02.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs2016
- Author(s)
  Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 1 Pages: 115-122
- DOI
  10.2131/jts.41.115
- NAID
  130005119778
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig2016
- Author(s)
  Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A
- Journal Title
  
  J Vet Med Sci
  
  Volume: 78 Pages: 873-876
- NAID
  130005154307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Impacts of Surgically-Performed Renal Denervation on the Cardiovascular and Electrophysiological Variables in the Chronic Atrioventricular Block Dogs: Comparison with Those of Amiodarone2016
- Author(s)
  Wada T, Ohara H, Nakamura Y, Yokoyama H, Cao X, Izumi-Nakaseko H, Ando K, Murakoshi N, Sato A, Aonuma K, Takahara A, Nakazato Y, Sugiyama A.
- Journal Title
  
  Circ J
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461042
[Journal Article] Why can dl-sotalol prolong the QT Interval in vivo despite its weak inhibitory effect on hERG K+ channels in vitro? : electrophysiological and pharmacokinetic analysis with the halothane-anesthetized guinea-pig model2016
- Author(s)
  Katagi J, Nakamura Y, Cao X, Ohara H, Honda A, Izumi-Nakaseko H, Ando K, Sugiyama A
- Journal Title
  
  Cardiovasc Toxicol
  
  Volume: 16 Issue: 2 Pages: 138-146
- DOI
  10.1007/s12012-015-9322-2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs2016
- Author(s)
  Cao X, Nakamura Y, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A
- Journal Title
  
  J Toxicol Sci
  
  Volume: 41 Pages: 439-447
- NAID
  130005152342
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations2016
- Author(s)
  Lubna NJ, Nakamura Y, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: 6 Pages: 739-744
- DOI
  10.2131/jts.41.739
- NAID
  130005281918
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08559
[Journal Article] Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO-AE1-329 in the halothane-anesthetized dogs2015
- Author(s)
  Nomura H, Nakamura Y, Cao X, Honda A, Katagi J, Ohara H, Izumi-Nakaseko H, Satoh Y, Ando K, Sugiyama A
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 761 Pages: 217-225
- DOI
  10.1016/j.ejphar.2015.06.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Intravenous administration of apomorphine does not induce long QT syndrome: experimental evidence from in vivo canine models2015
- Author(s)
  Watanabe Y, Nakamura Y, Cao X, Ohara H, Yamazaki Y, Murayama N, Sugiyama Y, Izumi-Nakaseko H, Ando K, Yamazaki H, Sugiyama A
- Journal Title
  
  Basic Clin Pharmacol Toxicol
  
  Volume: 116 Issue: 6 Pages: 468-475
- DOI
  10.1111/bcpt.12343
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.2015
- Author(s)
  Yamazaki-Hashimoto Y, Nakamura Y, Ohara H, Cao X, Kitahara K, Izumi-Nakaseko H, Ando K, Yamazaki H, Ikeda T, Yamazaki J, Sugiyama A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 40 Issue: 1 Pages: 33-42
- DOI
  10.2131/jts.40.33
- NAID
  130004904019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study2014
- Author(s)
  Nakamura Y., Matsuo J., Miyamoto N., Ojima A., Ando K., Kanda Y., Sawada K., Sugiyama A., Sekino Y.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 124 Issue: 4 Pages: 494-501
- DOI
  10.1254/jphs.13248FP
- NAID
  130003391508
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590322, KAKENHI-PROJECT-25460344
[Journal Article] Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolimod-induced atrioventricular conduction block and QT-interval prolongation.2014
- Author(s)
  Yagi Y, Nakamura Y, Kitahara K, Harada T, Kato K, Ninomiya T, Cao X, Ohara H, Izumi-Nakaseko H, Suzuki K, Ando K, Sugiyama A
- Journal Title
  
  Toxicology and applied pharmacology
  
  Volume: 16 Issue: 1 Pages: 39-47
- DOI
  10.1016/j.taap.2014.09.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs.2014
- Author(s)
  Izumi-Nakaseko H, Nakamura Y, Cao X, Ohara H, Yamazaki Y, Ueda N, Ando K, Sugiyama A
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 740 Pages: 263-270
- DOI
  10.1016/j.ejphar.2014.06.064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Effects of pH on Nifekalant-Induced Electrophysiological Change Assessed in the Langendorff Heart Model of Guinea Pigs2014
- Author(s)
  Kazuyuki Kazusa, Yuji Nakamura, Yudai Watanabe, Kentaro Ando, Atsushi Sugiyama
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 124 Issue: 2 Pages: 153-159
- DOI
  10.1254/jphs.13127FP
- NAID
  130003391474
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Cardiohemodynamic and electrophysiological effects of anti-influenza drug oseltamivir in vivo and in vitro2013
- Author(s)
  Kitahara K, Nakamura Y, TsuneokaY, Adachi-Akahane S, Tanaka H, Yamazaki H, Takahara A, Yamazaki J, Ikeda T, Sugiyama A
- Journal Title
  
  Cardiovas Toxicol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590237
[Journal Article] Electrophysiological effects of an anti-influenza drug oseltamivir on the guinea-pig atrium: comparison with those of pilsicainide2013
- Author(s)
  Akira Takahara, Sanae Suzuki, Mihoko Hagiwara, Shuhei Nozaki, Atsushi Sugiyama
- Journal Title
  
  Biological & pharmaceutical bulletin
  
  Volume: 36 Pages: 1650-1652
- NAID
  130004147313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460344
[Journal Article] Microminipig, a non-rodent experimental animal optimized for life science research.In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome : Development of Chronic Atrioventricular Block Model of Microminipig.2011
- Author(s)
  Sugiyama A, Nakamura Y, Akie Y, Saito H, Izumi Y, Yamazaki H, Kaneko N, Itoh K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 115 Pages: 122-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590237
[Journal Article] Microminipig, a non-rodent experimental animal optimized for life science research. In vivo proarrhythmia models of drug-Induced long QT syndrome: Development of chronic atrioventricular block model of microminipig2011
- Author(s)
  Sugiyama A, Nakamura Y, Akie Y, Saito H, Izumi Y, Yamazaki H, Kaneko N, Itoh K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 115 Pages: 122-126
- NAID
  10029891843
- URL
  https://www.jstage.jst.go.jp/article/jphs/115/2/115_10R21FM/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590237
[Journal Article] Measurements of cardiac ion channel subunits in the chronic atrioventricular block dog2011
- Author(s)
  Takahara A, Wagatsuma H, Aritomi S, Konda T, Akie Y, Nakamura Y, Sugiyama A
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 116 Pages: 132-135
- NAID
  10029894257
- URL
  https://www.jstage.jst.go.jp/article/jphs/116/1/116_11019SC/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590237
[Journal Article] Utilities of a halothane-anesthetized, closed-chest, guinea pig as a model to assess the drug-induced QT-interval prolongation2009
- Author(s)
  Sakaguchi Y, Takahara A, Nakamura Y, Akie Y, Sugiyama A
- Journal Title
  
  Basic Clin. Pharmacol. Toxicol 104(1)
  
  Pages: 43-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590532
[Journal Article] Long-term blockade of L/N-type Ca^<2+> channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.2009
- Author(s)
 Takahara A, Nakamura Y, Wagatsuma H, Aritomi S, Nakayama A, Satoh Y, Akie Y, Sugiyama A
- Journal Title
 
 Br. J. Pharmacol (in press)
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19590532
[Journal Article] Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion-channel blockers bepridil and amiodarone2008
- Author(s)
  Takahara A, Nakamura Y, Sugiyama A
- Journal Title
  
  Eur. J. Pharmacol 596(1-3)
  
  Pages: 127-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590532
[Journal Article] Comparison of electropharmacological effects of bepridil and sotalol in the halothane-anesthetized dogs2008
- Author(s)
  Ishizaka T, Takahara A, Iwasaki H, Mitsumori Y, Kise H, Nakamura Y, Sugiyama A.
- Journal Title
  
  Circ. J. 72(6)
  
  Pages: 1003-1011
- NAID
  110006783841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590532
[Journal Article] Chronic left atrial volume overload abbreviates the action potential duration of the canine pulmonary vein myocardium via activation of IK channel2008
- Author(s)
  Nouchi H, Takahara A, Nakamura H, Namekata I, Sugimoto T, Tsuneoka Y, Takeda K, Tanaka T, Shigenobu K, Sugiyama A, Tanaka H
- Journal Title
  
  Eur. J. Pharmacol 597(1-3)
  
  Pages: 80-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590532
[Journal Article] Cardiac effects of L/N-type Ca^<2+> channel blocker cilnidipine in anesthetized dogs.2007
- Author(s)
 Takahara A, Iwasaki H, Nakamura Y, Sugiyama A
- Journal Title
 
 Eur J Pharmacol (印刷中)
- Description
 「研究成果報告書概要(和文)」より
- Data Source
 KAKENHI-PROJECT-17590216
[Journal Article] Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs.2007
- Author(s)
  Ando K, Sugiyama A, Takahara A, Satoh Y, Ishizaka T, Nakamura Y, Hashimoto K
- Journal Title
  
  J Pharmacol. Sci 558・1-3
  
  Pages: 151-158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] In vivo electropharmacological effects of amiodarone and candesartan on atria of the chronic atrioventricular block dogs.2007
- Author(s)
  Wang K, Takahara A, Nakamura Y, Aonuma K, Matsumoto M, Sugiyama A*
- Journal Title
  
  J Pharmacol Sci 103
  
  Pages: 207-213
- NAID
  10024312639
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs2007
- Author(s)
  Ando K, Sugiyama A, Takahara A, Satoh Y, Ishizaka T, Nakamura Y, Hashimoto K
- Journal Title
  
  Eur J Pharmacol 558-1-3
  
  Pages: 151-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Cardiac effects of L/N-type Ca^<2+> channel blocker cilnidipine in anesthetized dogs.2007
- Author(s)
 Takahara A, Iwasaki H, Nakamura Y, Sugiyama A.
- Journal Title
 
 Eur. J. Pharmacol 565(1-3)
 
 Pages: 166-170
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19590532
[Journal Article] The chronic atrioventricular block dog as a model of lethal ventricular tachyarrhythmia: cardiovascular and neurohumoral profiles and its potential arrhythmogenic mechanisms.2007
- Author(s)
  Takahara A, Sugiyama A, Satoh Y, Iwasaki H, Nakamura Y, Hashimoto K
- Journal Title
  
  Basic ＆ Clinical Pharmacology ＆ Toxicology (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] The chronic atrioventricular block dog as a model of lethal ventricular tachyarrhythmia : cardiovascular and neurohumoral profiles and its potential arrhythmogenic mechanisms.2007
- Author(s)
  Takahara A, Sugiyama A*, Satoh Y, Iwasaki H, Nakamura Y, Hashimoto K
- Journal Title
  
  Basic ＆ Clinical Pharmacology ＆ Toxicology (印刷中)
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Cardiovascular profile of the canine torsades de pointes arrhythmia model assessed by echocardiographic and haemodynamic methods2007
- Author(s)
  Takahara A, Sugiyama A, Satoh Y, Iwasaki H, Nakamura Y, Hashimoto K.
- Journal Title
  
  Basic Clin. Pharmacol. Toxicol 101(1)
  
  Pages: 35-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590532
[Journal Article] Cardiac effects of L/N-type Ca^<2+> channel blocker cilnidipine in anesthetized dogs.2007
- Author(s)
 Takahara A, Iwasaki H, Nakamura Y, Sugiyama A*
- Journal Title
 
 Eur J Pharmacol (印刷中)
- Data Source
 KAKENHI-PROJECT-17590216
[Journal Article] In vivo elect ropharmacological effects of amiodarone and candesartan on atria of the chronic atrioventricular block dogs.2007
- Author(s)
  Wang K, Takahara A, Nakamura Y, Aonuma K, Matsumoto M, Sugiyama A
- Journal Title
  
  J Pharmacol Sci 103・3
  
  Pages: 207-213
- NAID
  10024312639
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Analysis of proarrhythmic potential of antipsychotics risperidone and olanzapine in anesthetized dogs.2007
- Author(s)
  Ando K, Sugiyama A*, Takahara A, Satoh Y, Ishizaka T, Nakamura Y, Hashimoto K
- Journal Title
  
  Eur J Pharmacol 558
  
  Pages: 151-158
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Analysis of arrhythmogenic profile in a canine model of chronic atrioventricular block by comparing in vitro effects of the class III antiarrhythmic drug nifekalant on the ventricular action potential indices between normal heart and atrioventricular block heart.2007
- Author(s)
  Takahara A, Nakamura H, Nouchi H, Tamura T, Tanaka T, Shimada H, Tamura M, Tsuruoka N, Takeda K, Tanaka H, Shigenobu K, Hashimoto K, Sugiyama A*
- Journal Title
  
  J Pharmacol Sci 103
  
  Pages: 181-188
- NAID
  10024312542
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H_1 blocker terfenadine-induced torsades de pointes arrhythmias.2006
- Author(s)
  Takahara A, Sugiyama A*, Ishida Y, Wang K, Nakamura Y, Hashimoto K
- Journal Title
  
  Br J Pharmacol 147
  
  Pages: 634-641
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K^+ channel blocker-induced QT interval prolongation.2006
- Author(s)
  Takahara A, Sugiyama A*, Hashimoto K
- Journal Title
  
  Biol Pharm Bull 29
  
  Pages: 827-829
- NAID
  110005602197
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K^+ channel blocker-induced QT interval prolongation.2006
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K
- Journal Title
  
  Biol Pharm Bull 29・4
  
  Pages: 827-829
- NAID
  110005602197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H_1 blocker terfenadine-induced torsadesde pointes arrhythmias.2006
- Author(s)
  Takahara A, Sugiyama A, Ishida Y, Wang K, Nakamura Y, Hashimoto K
- Journal Title
  
  Br J Pharmacol 147・6
  
  Pages: 634-641
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Comparison of four rate-correction algorisms for ventricular repolarization period in assessing net repolarization delay by I_<Kr> blockers.2006
- Author(s)
 Takahara A, Sugiyama A*, Satoh Y, Hashimoto K
- Journal Title
 
 J Pharmacol Sci 102
 
 Pages: 396-404
- Data Source
 KAKENHI-PROJECT-17590216
[Journal Article] Comparison of four rate-correction algorisms for ventricular repolarization period in assessing net repolarization delay by I_Kr blockers.2006
- Author(s)
  Takahara A, Sugiyama A, Satoh Y, Hashimoto K
- Journal Title
  
  J Pharmacol. Sci 102・4
  
  Pages: 396-404
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K^+ channel blocker-induced QT interval prolongation2006
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K
- Journal Title
  
  Biol Pharm Bull 29-4
  
  Pages: 827-829
- NAID
  110005602197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Acute hypokalemia may not be an effective way to sensitize the in situ canine heart for sparfloxacin-induced long QT syndrome2006
- Author(s)
  Chiba K, Sugiyama A, Watanabe K, Takasuna K, Hashimoto K
- Journal Title
  
  J Pharmacol Sci 100・1
  
  Pages: 88-92
- NAID
  10018241262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Comparison of four rate-correction algorisms for ventricular repolarization period in assessing net repolarization delay by I_<Kr> blockers2006
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Hashimoto K
- Journal Title
 
 J Pharmacol. Sci 102-4
 
 Pages: 393-404
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-17590216
[Journal Article] Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation2005
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K
- Journal Title
  
  Br J Pharmacol 146・4
  
  Pages: 561-567
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] An antipsychotic and antiemetic drug prochiorperazine delays the ventricular repolarization of the in situ canine heart.2005
- Author(s)
  Satoh Y, Sugiyama A, Takahara A, Ando K, Wang K, Honsho S, Hashimoto K.
- Journal Title
  
  J Pharmacol Sci 97
  
  Pages: 101-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] A red wine vinegar beverage can inhibit the renin-angiotensin system : experimental evidence in vivo2005
- Author(s)
  Honsho S, Sugiyama A, Takahara A, Satoh Y, Nakamura Y, Hashimoto K
- Journal Title
  
  Biol Pharm Bull 28・7
  
  Pages: 1208-1210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Halothane sensitizes the canine heart to pharmacological I_<Kr> blockade2005
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Wang K, Honsho S, Hashimoto K.
- Journal Title
 
 Eur J Pharmacol 507(1-3)
 
 Pages: 169-177
- Data Source
 KAKENHI-PROJECT-15590222
[Journal Article] Halothane sensitizes the canine heart to pharmacological I_<Kr> blockade2005
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Wang K, Honsho S, Hashimoto K
- Journal Title
 
 Pur J Pharmacol 507(1-3)
 
 Pages: 169-177
- Description
 「研究成果報告書概要(和文)」より
- Data Source
 KAKENHI-PROJECT-15590222
[Journal Article] Comparison of the direct negative dromotropic effect of a new calcium channel blocker cilnidipine with that of nicardipine.2005
- Author(s)
  Sugiyama A, Satoh Y, Takahara A, Ando K, Nakamura Y, Hashimoto K.
- Journal Title
  
  Heart Vessels (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Halothane sensitizes the guinea pig heart to pharmacological IKr blockade : comparison with urethane anesthesia2005
- Author(s)
  Sakaguchi Y, Sugiyama A, Takao S, Akie Y, Takahara T, Hashimoto K
- Journal Title
  
  J Pharmacol Sci 99・2
  
  Pages: 185-190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing2005
- Author(s)
  Sugiyama A, Takahara A, Honsho S, Nakamura Y, Hashimoto K
- Journal Title
  
  J Pharmacol Sci 98・3
  
  Pages: 315-318
- NAID
  10025729179
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Comparison of the direct negative dromotropic effect of a new calcium channel blocker cilnidipine with that of nicardipine.2005
- Author(s)
  Sugiyama A, Satoh Y, Takahara A, Ando K, Nakamura Y, Hashimoto K
- Journal Title
  
  Heart Vessels (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Halothane sensitizes the canine heart to pharmacological I_<Kr> blockade.2005
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Wang K, Honsho S, Hashimoto K.
- Journal Title
 
 Eur J Pharmacol 507(1-3)
 
 Pages: 169-177
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-15590222
[Journal Article] An antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.2005
- Author(s)
  Satoh Y, Sugiyama A, Takahara A, Ando K, Wang K, Honsho S, Hashimoto K.
- Journal Title
  
  J Pharmacol Sci 97
  
  Pages: 101-106
- NAID
  10025725425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] A red wine vinegar beverage can inhibit the renin-angiotensin system : experimental evidence in vivo.2005
- Author(s)
  Honsho S, Sugiyama A, Takahara A, Satoh Y, Nakamura Y, Hashimoto K.
- Journal Title
  
  Biol Pharm Bull. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] The endothelium-dependent vasodilator action of a new beverage made of red wine vinegar and grape juice.2005
- Author(s)
  Takahara A, Sugiyama A, Honsho S, Sakaguchi Y, Akie Y, Nakamura Y, Hashimoto K.
- Journal Title
  
  Biol Pharm Bull 28(4)
  
  Pages: 754-756
- NAID
  110003665881
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] A red wine vinegar beverage can inhibit the renin-angiotensin system : experimental evidence in vivo.2005
- Author(s)
  Honsho S, Sugiyama A, Takahara A, Satoh Y, Nakamura Y, Hashimoto K.
- Journal Title
  
  Biol Pharm Bull (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacinig2005
- Author(s)
  Sugiyama A, Takahara A, Honsho S, Nakamura Y, Hashimoto K
- Journal Title
  
  J Pharmacol Sci 98・3
  
  Pages: 315-318
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590216
[Journal Article] Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.2004
- Author(s)
  Chiba K, Sugiyama A, Takasuna K, Hashimoto K.
- Journal Title
  
  Eur J Pharmacol 502
  
  Pages: 117-122
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of class I antiarrhythmic drugs on the digitalis- induced triggered activity arrhythmia model a rationale for the short-term use of class I drugs against triggered arrhythmias.2004
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K
- Journal Title
  
  Heart Vessels 19(1)
  
  Pages: 43-48
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of class I antiarrhythmic drugs on the digitalis-induced triggered activity arrhythmia model : a rationale for the short-term use of class I drugs against triggered arrhythmias.2004
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K.
- Journal Title
  
  Heart Vessels 19(1)
  
  Pages: 43-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Cardiovascular effects of an L/N-type Ca^<2+> channel blocker cilnidipine assessed in the chronic atrioventricular conductionblock dogs.2004
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Nakamura Y, Hashimoto K.
- Journal Title
 
 J Pharmacol Sci 96
 
 Pages: 219-223
- Description
 「研究成果報告書概要(和文)」より
- Data Source
 KAKENHI-PROJECT-15590222
[Journal Article] Cardiovascular effects of an L/N-type Ca^<2+> channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs.2004
- Author(s)
 Takahara A, Sugiyama A, Satoh Y, Nakamura Y, Hashimoto K.
- Journal Title
 
 J Phannacol Sci 96
 
 Pages: 219-223
- NAID
 10014166899
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-15590222
[Journal Article] Electropharma-cological effects of a spironolactone derivative, potassium canrenoate assessed in the halothane-anesthetized canine model.2004
- Author(s)
  Sugiyama A, Satoh Y, Takahara A, Ando K, Kai W, Honsho S, Nakamura Y, Hashimoto K.
- Journal Title
  
  J Phannacol Sci 96
  
  Pages: 436-443
- NAID
  10014075829
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.2004
- Author(s)
  Satoh Y, Sugiyama A, Takahara A, Hashimoto K.
- Journal Title
  
  J Cardiovasc Pharmacol 43(5)
  
  Pages: 715-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts2004
- Author(s)
  Chiba K, Sugiyama A, Takasuna K, Hashimoto K
- Journal Title
  
  Eur J Pharmacol 502
  
  Pages: 117-122
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of class I antiarrhythmic drugs on the digitalis induced triggered activity arrhythmia model : a rationale for the short-term use of class I drugs against triggered arrhythmias.2004
- Author(s)
  Takahara A, Sugiyama A, Hashimoto K
- Journal Title
  
  Heart Vessels 19(1)
  
  Pages: 43-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assesses using the in vivo canine models.2004
- Author(s)
  Satoh Y, Sugiyama A, Takahara A, Hashimoto K.
- Journal Title
  
  J Cardiovasc Pharmacol 43(5)
  
  Pages: 715-723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Electropharmacological effects of a spironolactone derivative, potassium canrenoate assessed in the halothane-anesthetized canine model.2004
- Author(s)
  Sugiyama A, Satoh Y, Takahara A, Ando K, Kai W, Honsho S, Nakamura Y, Hashimoto K.
- Journal Title
  
  J Pharmacol Sci 96
  
  Pages: 436-443
- NAID
  10014075829
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Relationship between several Kampo medicines-induced phosphodiesterase inhibition and smooth muscle relaxation ofgastrointestinal tract tissues of rats.2003
- Author(s)
  Saegusa Y, Sugiyama A, Takahara A, Nagasawa Y, Hashimoto K.
- Journal Title
  
  J Pharmacol Sci 93
  
  Pages: 62-68
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.2003
- Author(s)
  Takahara A, Sugiyama A, Satoh Y, Hashimoto K.
- Journal Title
  
  Eur J Pharmacol 476(/1-2)
  
  Pages: 115-122
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of mexiletine on the canine model of sparfioxacin-induced long QT syndrome.2003
- Author(s)
  Takahara A, Sugiyama A, Satoh Y, Hashimoto K.
- Journal Title
  
  Eur J Pharmacol 476(/1-2)
  
  Pages: 115-122
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Relationship between several Kampo medicines-induced phosphodiesterase inhibition and smooth muscle relaxation of gastrointestinal tract tissues of rats.2003
- Author(s)
  Saegusa Y, Sugiyama A, Takahara A, Nagasawa Y, Hashimoto K.
- Journal Title
  
  J Pharmacol Sci 93
  
  Pages: 62-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Effects of clinically available Herbal Medicine (Kampo extracts) on the phosphodiesterase activity in rat hearts.2003
- Author(s)
  Saegusa Y, Sugiyama A, Hashimoto K.
- Journal Title
  
  Yamanashi Med J 18(2)
  
  Pages: 33-36
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat.2003
- Author(s)
  Sugiyama A, Saitoh M, Takahara A, Satoh Y, Hashimoto K
- Journal Title
  
  Nutrition Res 23
  
  Pages: 1291-1296
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Journal Article] Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat.2003
- Author(s)
  Sugiyama A, Saitoh M, Takahara A, Satoh Y, Hashimoto K.
- Journal Title
  
  Nutrition Res 23
  
  Pages: 1291-1296
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590222
[Patent] 催不整脈モデル動物2008
- Inventor(s)
  杉山篤、高原章、佐藤吉沖
- Industrial Property Rights Holder
  株式会社イナリサーチ
- Filing Date
  2008-02-29
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] Practical Application of New Vaughan Williams Classification2023
- Author(s)
  Sugiyama A, Kambayashi R, Goto A, Izumi-Nakaseko H
- Organizer
  第8回日本心血管協会学術集会 International session
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08430
[Presentation] Efficacy and safety of antiarrhythmic drugs on the AF patients: quantitative evaluation using animal models2023
- Author(s)
  Sugiyama A
- Organizer
  16th APHRS & CardioRhythm 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08430
[Presentation] Combination of antiparasitic agent niclosamide and β-blocker can cause Kounis syndrome2023
- Author(s)
  Sugiyama A, Kambayashi R, Goto A, Izumi-Nakaseko H
- Organizer
  第8回日本心血管協会学術集会
- Data Source
  KAKENHI-PROJECT-23K08430
[Presentation] Analysis of electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the canine heart2019
- Author(s)
  Chiba K, Goto A, Hagiwara-Nagasawa M, Kambayashi R, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] LapatinibはQT間隔を延長するが、致死的な不整脈を誘発しない2018
- Author(s)
  安東賢太郎、内藤篤彦、後藤愛、中村裕二、長澤(萩原)美帆子、千葉浩輝、中瀬古(泉)寛子、杉山篤
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] LapatinibはQT間隔を延長するが、致死的な不整脈を誘発しない2018
- Author(s)
  安東賢太郎、内藤篤彦、中村裕二、長澤 (萩原) 美帆子、後藤愛、千葉浩輝、Nur Jaharat Lubna、中瀬古(泉) 寛子、杉山篤
- Organizer
  第138回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] LapatinibはQT間隔を延長するが、致死的な不整脈を誘発しない2018
- Author(s)
  安東賢太郎、内藤篤彦、後藤愛、中村裕二、長澤 (萩原) 美帆子、千葉浩輝、中瀬古(泉) 寛子、杉山篤
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] LapatinibはQT間隔を延長するが、致死的な不整脈を誘発しない2018
- Author(s)
  安東賢太郎、内藤篤彦、中村裕二、長澤(萩原)美帆子、後藤愛、千葉浩輝、 Nur Jaharat Lubna、中瀬古(泉)寛子、杉山篤
- Organizer
  第138回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] 腫瘍循環器学: 拡張不全はsunitinib誘発性心血管有害事象を予測する早期指標になりうる2017
- Author(s)
  和田剛, 安東賢太郎, 千葉浩輝, 曹新, 中村裕二, 中瀬古(泉)寛子, 杉山篤
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] Donepezilの心血管安全性薬理評価－ハロセン麻酔犬生体位心臓を用いて－2017
- Author(s)
  萩原美帆子, 中村裕二, 後藤愛, 千葉浩輝, Nur Jaharat Lubna, 中瀬古(泉)寛子, 安東賢太郎, 内藤篤彦, 杉山篤
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] 細胞内Ca2+動態修飾薬caldaret（MCC-135）の左室収縮および拡張能に対する作用2017
- Author(s)
  杉山篤, 中村裕二, 安東賢太郎, 後藤愛, Nur Jaharat Lubna, 千葉浩輝, 長澤（萩原）美帆子, 中瀬古（泉）寛子, 内藤篤彦
- Organizer
  第71回東邦医学会総会
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] Pharmacological characterization of an extremely small-size miniature pig 'microminipig' as an in vivo experimental model for cardiac safety pharmacology2017
- Author(s)
  Sugiyama A, Hagiwara-Nagasawa M, Nakamura Y, Izumi-Nakaseko H, Ando K, Naito AT
- Organizer
  The 3rd annual meeting of China Safety Pharmacological Society, The 6th International Safety Pharmacology Symposium in China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] M201-Aは高い有効性と安全性を有する心房細動治療薬候補化合物である2017
- Author(s)
  萩原美帆子, 中村裕二, 岩田邦男, 後藤愛, 千葉浩輝, Nur Jaharat Lubna, 中瀬古(泉)寛子, 安東賢太郎, 内藤篤彦, 金子昇, 杉山篤
- Organizer
  第三回 J-ISCP学術集会
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] 心周期における拡張不全と収縮不全の位置づけ2016
- Author(s)
  杉山篤,中村裕二,和田剛,中瀬古（泉）寛子,安東賢太郎
- Organizer
  第43回比較心電図研究会
- Place of Presentation
  東京大学中島董一郎ホール（東京都文京区）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] 心臓安全性評価：非臨床毒性データからの予測2016
- Author(s)
  杉山篤, 中村裕二, 和田剛, 中瀬古（泉）寛子, 安東賢太郎
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-16K08559
[Presentation] Analysis of cardiovascular effects of terfenadine in comparison with those of fexofenadine with the halothane-anesthetized dogs2016
- Author(s)
  Kentaro Ando, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Atsushi Sugiyama
- Organizer
  16th Safety Pharmacology Annual Meeting
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2016-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] Cardio-Oncology:抗悪性腫瘍薬sunitinibはHFrEFに先行してHFpEFを惹起する2016
- Author(s)
  和田剛, 安東賢太郎, 千葉浩輝, 曹新, 中村裕二, 中瀬古（泉）寛子, 杉山篤
- Organizer
  第26回日本循環薬理学会
- Place of Presentation
  信州大学医学部（長野県松本市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K08246
[Presentation] Current situation and future plan in Japanese activity of Kirishima Meeting2015
- Author(s)
  Atsushi Sugiyama
- Organizer
  Safety Pharmacology Society, 15th annual meeting
- Place of Presentation
  プラハ、チェコ共和国
- Year and Date
  2015-10-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] 薬物性不整脈2015
- Author(s)
  杉山篤
- Organizer
  第51回日本小児循環器学会総会・学術集会
- Place of Presentation
  ホテル日航東京（東京都港区）
- Year and Date
  2015-07-18
- Invited
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] The current trends and issues on integrated cardiac safety.2014
- Author(s)
  Sugiyama A
- Organizer
  The 5th DIA cardiac safety workshop in Japan
- Place of Presentation
  KFCホール両国（東京都・墨田区）
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] Overview and raising issues.2014
- Author(s)
  Sugiyama A
- Organizer
  The 5th DIA cardiac safety workshop in Japan
- Place of Presentation
  KFCホール両国（東京都・墨田区）
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] オセルタミビルの心血行動態および電気生理学的作用2013
- Author(s)
  北原健, 中村裕二, 恒岡弥生, 赤羽悟美, 田中光, 山崎浩史, 高原章, 山崎純一, 池田隆徳, 杉山篤
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22590237
[Presentation] Chronic atrioventricular(AV)block sensitizes monkey heart for drug-induced Torsades de Pointes(TdP)via biochemicalbiochemical, anatomical and electrophysiological remodelings2009
- Author(s)
  Sugiyama A, Nakamura Y, Saitoh M, Takahara A, Sakamoto K, Sasaki H, Hombo T, Wakasa Y, Nomura M
- Organizer
  The 2007 Autumn Meeting of The British Society for Cardiovascular Research
- Place of Presentation
  London
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] 慢性房室ブロック犬心筋におけるK^+チャネルmRNAの発現抑制2008
- Author(s)
  高原章、我妻広貴、有冨静、今田智之、秋江靖樹、杉山篤
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] Chronic atrioventricular block abbreviated the action potential duration of canine pulmonary vein myocardium2008
- Author(s)
  高原章、野内秀明、田中光、杉山篤
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] 慢性完全房室ブロックモデル動物を用いた薬物性QT延長症候群のリスク評価2007
- Author(s)
  杉山篤、佐藤吉沖、高原章
- Organizer
  第24回日本心電学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2007-10-06
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] Chronic Atrioventricular(AV)Block Sensitizes Monkey Heart for Drug-Induced Torsades de Pointes(TdP)via Biochemical, Anatomical and Electrophysiological Remodelings.2007
- Author(s)
  杉山篤
- Organizer
  The 2007 Autumn Meeting of The British Society for Cardiovascular Research
- Place of Presentation
  St. Thomas' Hospital
- Year and Date
  2007-09-24
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] 新規サル催不整脈モデルを用いたtorsades de pointes(TdP)リスク評価系の確立2007
- Author(s)
  坂本憲吾、大谷光嗣、若狭芳男、高原章、杉山篤
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  東京
- Year and Date
  2007-06-28
- Data Source
  KAKENHI-PROJECT-19590532
[Presentation] Azithromycinの血行動態および電気生理学的作用：ハロセン麻酔犬モデルでの評価
- Author(s)
  小原浩, 中村裕二, 安東賢太郎, 渡辺雄大, 曹新, 山﨑有希子, 池田隆徳, 杉山篤
- Organizer
  第30回日本心電学会学術集会
- Place of Presentation
  リンクステーションホール青森、青森市、青森県
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] 不整脈心電図の読み方
- Author(s)
  杉山篤
- Organizer
  第5回安全性薬理研究会　学術年会
- Place of Presentation
  東京大学、文京区、東京都
- Invited
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] Effects of Selective Ikr Channel Blockade by E-4031 on Ventricular Electro-Mechanical Relationship in the Halothane-Anesthetized Dogs
- Author(s)
  中瀬古寛子, 中村裕二, 曹新, 小原浩 ,山崎有希子, 上田直也, 安東賢太郎, 杉山篤
- Organizer
  第5回安全性薬理研究会　学術年会
- Place of Presentation
  東京大学、文京区、東京都
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] 腎交感神経除去術の慢性房室ブロック犬の心血管系に対する作用：シルニジピンおよびアミオダロンとの比較
- Author(s)
  小原浩, 中村裕二, 曹新, 横山浩史, 中瀬古寛子, 安東賢太郎, 村越伸行, 佐藤明, 青沼和隆, 高原章, 池田隆徳, 杉山篤
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター、仙台市、宮城県
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] Aminodaroneおよびdronedaroneの心房・心室有効不応期に対する作用：bepridilおよびdl-sotalolとの比較
- Author(s)
  小原浩, 中村裕二, 本川佳幸, 山﨑有希子, 曹新, 安東賢太郎, 池田隆徳, 杉山篤
- Organizer
  第18回アミオダロン研究会
- Place of Presentation
  経団連ホール、千代田区、東京都
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] オセルタミビルは高頻度刺激により誘発された心房細動を抑制する：ラット動静脈瘻心拡大モデルを用いた検討
- Author(s)
  灘みづき, 相本恵美, 八木啓太, 江沢亜耶, 杉山篤, 高原章
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター、仙台市、宮城県
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] 心房に対するオセルタミビルの電気生理学的作用：モルモット単離心房標本による検討
- Author(s)
  萩原美帆子, 鈴木早苗, 野崎修平, 杉山篤, 高原章
- Organizer
  第128回日本薬理学会関東部会
- Place of Presentation
  早稲田大学国際会議場、新宿区、東京都
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] アマンタジンの電気薬理学的作用：ハロセン麻酔犬モデルでの評価
- Author(s)
  曹新, 中村裕二, 小原浩, 山﨑有希子, 中瀬古寛子, 安東賢太郎, 杉山篤
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター、仙台市、宮城県
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] E-4031の電気生理学的特徴および催不整脈作用の評価：ハロセン麻酔および慢性房室ブロック犬モデルでの検討
- Author(s)
  中瀬古（泉）寛子, 中村裕二, 曹新, 上田直也, 小原浩, 山崎有希子, 安東賢太郎, 杉山篤
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター、仙台市、宮城県
- Data Source
  KAKENHI-PROJECT-25460344
[Presentation] Assessment of Testing Methods of the Drug-Induced Repolarization Delay and Arrythmias in an iPS-Derived Cardiomyocyte Sheet:Multi-Site Validation Study
- Author(s)
  中村裕二, 松尾純子, 宮本憲優, 小島敦子, 安東賢太郎, 諫田泰成, 澤田光平, 杉山篤, 関野祐子
- Organizer
  第5回日本安全性薬理研究会　学術年会
- Place of Presentation
  東京大学、文京区、東京都
- Data Source
  KAKENHI-PROJECT-25460344

1. TAKAHARA Akira (80377481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. 中村裕二 (10614894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. Sato Akira (30528469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. AONUMA Kazutaka (10375488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MURAKOSHI Nobuyuki (80447218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Kentaro Ando (90466904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. Sakaguchi Hisashi (40743026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMASHITA JUN (50335288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MASUMOTO HIDETOSHI (70645754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中瀬古寛子 (80408773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
11. 池田義 (40281092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 南方謙二 (60539675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Machino Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Wada Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. Cao Xin

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. Chiba Koki

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. 神林隆一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 後藤愛

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

ATSUSHI Sugiyama 杉山 篤

杉山 篤 スギヤマ アツシ

SUGIYAMA Atsushi 杉山 篤

Research Projects

Research Products

Co-Researchers

Exploring drug treatment strategies to avoid the occurrence of lethal arrhythmias associated with therapeutic hypothermiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of EP4 receptor agonist on the left ventricular diastolic function, and analysis of its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Estabrishment of non-clinical evaluating models in cardiotoxicities induced by a melecular targeted EGFR inhibitor for cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolomod-induced atrioventricular conduction blockPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RENAL DENERVATION: NOVEL THERAPY FOR RESISTANT HYPERTENSION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of therapeutic target molecules againstatrial fibrillation: Use of the canine persistent atrial fibrillation modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PHARMACOTHERAPEUTIC STRATEGY FOR PREVENTION OF CARDIAC SUDDEN DEATH CAUSED BY VENTRICULAR REPOLARIZATION ABNORMALITY

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search of upstream drugs for treatment of atrial fibrillation using a new canine atrial fibrillation modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dangerous QT prolongation can be assayed by using the chronic atrioventricular block dogPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

刺激伝導系におけるphosphodiesterase活性の測定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

イヌ心室性激発活動誘発不整脈モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 図解 薬害・副作用学 (みてわかる薬学)2023

Author(s)

ATSUSHI Sugiyama 杉山篤

杉山篤スギヤマアツシ

SUGIYAMA Atsushi 杉山篤

[Book] 図解薬害・副作用学 (みてわかる薬学)2023

[Book] 動物の心電図・心エコー・血圧・病理学検査　増補改訂版2013