ONO Takahiko 小野孝彦

Researcher Number	60243028
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2009 – 2011: Nagoya City University, 大学院・薬学研究科, 客員教授 2007 – 2008: University of Shizuoka, 薬学部, 教授 1995 – 2002: Kyoto Univ., Graduate School of Medicine Research Associate, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Experimental pathology / Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator PCR / Chemical carcinogenesis / Cloning / Carcinogenesis / Tumor suppressor / Urethelial cancer / LOH / 遺伝子クローニング / BBN / ラット発癌 … More / 化学発癌 / クローニング / 発癌 / 癌抑制遺伝子 / 尿路上皮癌 / connective tissue growth factor / 漢方薬 / 釣藤鈎 / Asymmetric dimethylarginine / 七物降下湯 / 慢性腎臓病(CKD) / 循環器・高血圧 / 細胞・組織 / 薬理学 / 高血圧 / 循環器 / 組織 / 細胞 / 遺伝子 / 凝固過程 / 第V因子 / メサンギウム細胞 … More Except Principal Investigator IL-12 / Th1 / Th2 / HIGA mouse / HIGAマウス / IgA腎症 / L-NAME / iNOS / NO / IgA / IgA Nephropathy / 半月体形成 / IL-4 / glomerular IgA / Analysis of pathogic gene / IgA nephropathy model mouse / QTL analysis / Polymeric IgA / High serum IgA / IgA nephropathy / LOD score / Microssatellite marker / 量的形質遺伝子座(QTL)解析 / polymeic IgA / 純系モデルマウス / 腎沈着IgA / 病的遺伝子解析 / IgA腎症モデルマウス / QTL解析 / 多量体IgA / 高IgA血症 / マクロファージ / ACE阻害剤 / CD4 / TGFβ / crescent formation / IFN-gamma / TGF-beta / IFN-γ / Th2バランス / モデルマウス Less

Systemic vascular disorders in chronic kidney disease and screening for protective drugsPrincipal Investigator
- Principal Investigator
  
  ONO Takahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya City University
Analytical study on aggravating mechanisms of glomerulonephritis through angiotensin-II type 1 receptorPrincipal Investigator
- Principal Investigator
  
  ONO Takahiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Quantitative trait locus analysis of genes responsible for the progression of IgA nephropathy - Analysis ofHIGA mice -
- Principal Investigator
  
  EN Muso
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tazuke Kofukai Medical Research Institute
The study of Immunological and hunodynamic factors which modify the pathophysiology of IgA nephropathy-the study using high IgA prone in bred strain (HIGA) of mice-
- Principal Investigator
  
  MUSO Eri
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KYOTO UNIVERSITY
The effect of Th1/Th2 dominance on the clinicopathological feature in murine model of IgA nephropathy
- Principal Investigator
  
  MUSO Eri
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  KYOTO UNIVERSITY
第V因子を介した培養ヒトメサンギウム細胞上での凝固過程の検討Principal Investigator
- Principal Investigator
  
  小野孝彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto University
Cloning of genes expressing in the early stage of rat bladder carcinogenesis induced by BBNPrincipal Investigator
- Principal Investigator
  
  ONO Takahiko, 杉山武敏
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  KYOTO UNIVERSITY

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 腎保護を意識した循環器薬の使い方.BEAMシリーズNo.1.循環器の基本薬を使いこなす2010
- Author(s)
  小野孝彦, 他共著
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21590172
[Book] 共著腎保護を意識した循環器薬の使い方BEAMシリーズNo.1.循環器の基本薬を使いこなす2010
- Author(s)
  小野孝彦, ほか
- Total Pages
  131
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-21590172
[Book] IgA腎症モデルマウス(HIGA)へのLPS投与による酸化ストレス・凝固系活性化を介した腎炎増悪. 腎とフリーラジカル第9集2008
- Author(s)
  下沢真木子、日浅俊介、劉寧、上村和秀、野垣文昭、武曾恵理、吉田治義、小野孝彦
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-19590152
[Journal Article] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by DDAH-ADMA-NO pathway2012
- Author(s)
  Fan Bai, Toshiaki Makino, Takahiko Ono, Hajime Mizukami
- Journal Title
  
  J.Nat.Med.
  
  Volume: (印刷中) Issue: 4 Pages: 583-590
- DOI
  10.1007/s11418-011-0625-8
- NAID
  10031088105
- Year and Date
  2012-02-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] 慢性腎臓病(CKD)における凝固系と凝固第Xa因子の役割(Review)2012
- Author(s)
  小野孝彦
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Pages: 449-453
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice2011
- Author(s)
  Ayaka Sumi, Natsuko Y Hanada, Fan Bai, Toshiaki Makino, Hajime Mizukami, Takahiko Ono
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34(6) Pages: 824-830
- NAID
  130000738056
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice2011
- Author(s)
  Sumi A, Makino T, Ono T, et al.
- Journal Title
  
  Biol.Phar.Bull.
  
  Volume: (印刷中)
- NAID
  130000738056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] Basic study and clinical practice of Kampo medicines in chronic kidney disease(CKD) : chronic glomerulonephritis and nephrosclerosis2009
- Author(s)
  Takahiko Ono, Toshiaki Makino
- Journal Title
  
  J Trad Med 26
  
  Pages: 230-234
- NAID
  10025956286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] Basic study and clinical practice of Kampo medicines in chronic kidney disease(CKD): chronic glomerulonephritis and nephrosclerosis2009
- Author(s)
  Takahiko Ono, Toshiaki Makino
- Journal Title
  
  J. Trad. Med.
  
  Volume: 26(5/6) Pages: 230-234
- NAID
  10025956286
- Data Source
  KAKENHI-PROJECT-21590172
[Journal Article] アンジオテンシンII受容体過剰発現マウスの塩分負荷血圧変動と性差・組織障害2009
- Author(s)
  大塚秀隆、上村和秀、北村久代、吉川俊博、大門貴志、山田浩、伊藤正樹、小野孝彦
- Journal Title
  
  Pharma Medica 27
  
  Pages: 160-162
- Data Source
  KAKENHI-PROJECT-19590152
[Journal Article] Soluble fibrin formation in the mesangial area of IgA nephropathy2007
- Author(s)
  Ning Liu, Noriko Mori, Noriyuki Iehara, Kazuhide Uemura, Atsushi Fukatsu, Toru Kita, Michio Matsuda and Takahiko Ono
- Journal Title
  
  Clin Exp Nephrol 11
  
  Pages: 71-76
- NAID
  10024140153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590152
[Journal Article] Lipopolysaccharide-triggered acute aggravation of mesangioproliferative glomerulonephritis through activation of coagulation in a high IgA strain of ddY mice
- Author(s)
  Makiko Shimosawa, Koji Sakamoto, Yuki Tomari, Kohei Kamikado, Hidetaka Otsuka, Ning Liu, Hisayo Kitamura, Kazuhide Uemura, Fumiaki Nogaki, Noriko Mori, Eri Muso, Haruyoshi Yoshida, and Takahiko Ono
- Journal Title
  
  Nephron Exp Nephrol (in press)
- Data Source
  KAKENHI-PROJECT-19590152
[Journal Article] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by DDAH-ADMA-NO pathway
- Author(s)
  Fan Bai, Toshiaki Makino, Takahik o Ono, Hajime Mizukami
- Journal Title
  
  J. Nat. Med.
  
  Volume: (in press)
- NAID
  10031088105
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] Effects of shichimotsukokato on hypertensive CKD model2011
- Author(s)
  白帆、牧野利明、小野孝彦、水上元
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] シンポジウム慢性腎臓病CKDと関連病態の漢方治療.高血圧を伴ったCKDに対する漢方治療の基礎と臨床2010
- Author(s)
  小野孝彦, 他
- Organizer
  第61回日本東洋医学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2010-06-06
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] 慢性腎臓病CKDと関連病態の漢方治療.～高血圧を伴ったCKDに対する漢方治療の基礎と臨床2010
- Author(s)
  小野孝彦ほか
- Organizer
  第61回日本東洋医学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2010-06-06
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] Protective Effects of Shichimotsukokato on Anti-Thy-1-Induced Irreversible Nephritis in Rats2010
- Author(s)
  Takhiko Ono, et al.
- Organizer
  43nd Annual Meeting, Renal Week 2010, Am.Soc.Nephrol.
- Place of Presentation
  デンバー市(アメリカコロラド州)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] ARBに七物降下湯の併用で尿蛋白の減少をみた慢性腎臓病の1例2010
- Author(s)
  小野孝彦ほか
- Organizer
  第40回日本東洋医学会東海支部学術総会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] ARBに七物降下湯の併用で尿蛋白の減少をみた慢性腎臓病の1例2010
- Author(s)
  小野孝彦, 他
- Organizer
  第40回日本東洋医学会東海支部学術総会
- Place of Presentation
  名古屋大学鶴友会館(愛知県)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] Protective Effects of Shichimotsukokato on Anti-Thy-1-Induced Irreversible Nephritis in Rats2010
- Author(s)
  Takhiko Ono, et al
- Organizer
  43nd Annual Meeting, Renal Week 2010, Am. Soc. Nephrol.
- Place of Presentation
  デンバー、アメリカコロラド州
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] シンポジウム慢性腎臓病(CKD)と漢方:慢性腎炎・腎硬化症への漢方方剤の運用と基礎的検討2009
- Author(s)
  小野孝彦, 牧野利明
- Organizer
  第26回和漢医薬学会
- Place of Presentation
  千葉市
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-21590172
[Presentation] Heminephrectomy accelerates glomerular matrix expansion and coagulation pathway in diabetic nephropathy of db/db mice2008
- Author(s)
  Ayaka Sumi, Natsuko Yamanaka, Ning Liu, Hisayo Kitamura, Kazuhide Uemura, Takahiko Ono
- Organizer
  Renal Week 2008 by Am. Soc. Nephrol
- Place of Presentation
  (Philadelphia,USA) Abstract
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] 凝固第Xa因子によるメサンギウム細胞の細胞外基質産生亢進と内因性第V因子の役割2008
- Author(s)
  泊裕輝、隅彩香、劉寧、北村久代、上村和秀、小野孝彦
- Organizer
  第51回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  福岡(第50巻)
- Year and Date
  2008-05-31
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] アンジオテンシンII受容体過剰発現マウスの血圧に対する塩分負荷および性差の影響2008
- Author(s)
  大塚秀隆、上村和秀、北村久代、吉川俊博、大門貴志、山田浩、伊藤正樹、小野孝彦
- Organizer
  第51回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  福岡(第50巻)
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] HIGAマウスはToll-like receptor 4を発現し、LPS投与により凝固系活性化を介して腎炎を増悪する2008
- Author(s)
  小野孝彦、下沢真木子、泊裕輝、大塚秀隆、劉寧、北村久代、上村和秀、野垣文昭、森典子、武曾恵理、吉田治義
- Organizer
  第51回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  福岡(第50巻)
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] アンジオテンシンII受容体過剰発現マウスの塩分負荷による血圧変動と性差・組織障害2008
- Author(s)
  小野孝彦、上村和秀、大塚秀隆、北村久代、吉川俊博、大門貴志、山田浩、伊藤正樹
- Organizer
  第31回日本高血圧学会総会(抄録集)
- Place of Presentation
  札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] 2型糖尿病モデルdb/dbマウスの片腎摘による糸球体内基質増生と凝固の進行2008
- Author(s)
  隅彩香、山中奈津子、劉寧、北村久代、上村和秀、小野孝彦
- Organizer
  第51回日本腎臓学会(講演抄録集)
- Place of Presentation
  福岡(第50巻)
- Year and Date
  2008-06-01
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] アンジオテンシンII受容体過剰発現マウスの塩分負荷による血圧変動と性差・組織障害2008
- Author(s)
  小野孝彦
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌市
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] 実験的腹膜線維症における凝固第Xa因子阻害剤の抑制効果2008
- Author(s)
  加藤こずえ、北本将幸、齊藤宏樹、北村久代、上村和秀、野垣文昭、森典子、武田敏也、小野孝彦
- Organizer
  日本透析医学会第53回学術集会(講演抄録集)
- Place of Presentation
  神戸
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] HIGAマウスはToll-like receptor 4を発現し、LPS投与により凝固系活性化を介して腎炎を2008
- Author(s)
  小野孝彦
- Organizer
  第51回日本腎臓学会
- Place of Presentation
  福岡市
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] IgA腎症モデルHIGAマウスにおけるvon Willebrand Factorの糸球体への沈着2008
- Author(s)
  上村和秀、三瓶祐貴、大塚秀隆、野垣文昭、武曾恵理、吉田治義、小野孝彦
- Organizer
  第51回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  福岡(第50巻)
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] Factor Xa in combination with endogenous factor V promotes production of extracellular matrix proteins in cultured human mesangial cells2007
- Author(s)
  Yuki Tomari, Yorimichi Horiuchi, Ning Liu, Kazuhide Uemura, Takahiko Ono
- Organizer
  Renal Week 2007 by Am. Soc. Nephrol(Abstract)
- Place of Presentation
  San Fransisco, USA
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] ワークショップ「腎障害と免疫・凝固異常」、腎炎における凝固系と炎症の関連2007
- Author(s)
  小野孝彦、森典子
- Organizer
  第37回日本腎臓学会西部(日本腎臓学会誌)
- Place of Presentation
  福井(第49巻)
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] Effects of the herbal medicine Sairei-to on rat peritoneal fibrosis partly through suppression of oxidative stress2007
- Author(s)
  Masayuki Kitamoto, Hiroki Saito, Hisayo Kitamura, Kazuhide Uemura, Fumiaki Nogaki, Toshiya Takeda, Noriko Mori, Takahiko Ono
- Organizer
  Renal Week 2007 by Am. Soc. Nephrol(Abstract)
- Place of Presentation
  SanFransisco, USA
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] 実験的メサンギウム増殖性腎炎の尿細管上皮細胞における凝固過程の進行と上皮細胞障害2007
- Author(s)
  足立秀樹、劉寧、長谷川貴通、北村久代、上村和秀、小野孝彦
- Organizer
  第50回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  浜松(第49巻)
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] IgA腎症モデルマウス(HIGA)へのLPS投与における酸化ストレスと凝固系活性化を介した腎炎増悪機序2007
- Author(s)
  下沢真木子、日浅俊介、劉寧、上村和秀、野垣文昭、森典子、武曾恵理、吉田治義、小野孝彦
- Organizer
  第50回日本腎臓学会(日本腎臓学会誌)
- Place of Presentation
  浜松(第49巻)
- Year and Date
  2007-05-27
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] ワークショップ「腎障害と免疫・凝固異常」、腎炎における凝固系と炎症の関連2007
- Author(s)
  小野孝彦
- Organizer
  第37回日本腎臓学会西部学術大会
- Place of Presentation
  福井市
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590152
[Presentation] 実験的被嚢性腹膜硬化症(EPS)における柴苓湯の抑制効果2007
- Author(s)
  北本将幸、齊藤宏樹、北村久代、上村和秀、野垣文昭、森典子、武田敏也、小野孝彦
- Organizer
  日本透析医学会第52回学術集会(講演抄録集)
- Place of Presentation
  大阪
- Year and Date
  2007-06-17
- Data Source
  KAKENHI-PROJECT-19590152

1. MUSO Eri (10190852)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. UEMURA Kazuhide (20303844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
3. ITO Masaki (70295559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. MAKINO Toshiaki (80326561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. SHIMADA Toshihide (30231690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Rei (60144565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 杉山武敏 (20030851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 逢坂光彦 (20252463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONO Takahiko 小野 孝彦

Research Projects

Research Products

Co-Researchers

Systemic vascular disorders in chronic kidney disease and screening for protective drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analytical study on aggravating mechanisms of glomerulonephritis through angiotensin-II type 1 receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative trait locus analysis of genes responsible for the progression of IgA nephropathy - Analysis ofHIGA mice -

Principal Investigator

Project Period (FY)

Research Category

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The study of Immunological and hunodynamic factors which modify the pathophysiology of IgA nephropathy-the study using high IgA prone in bred strain (HIGA) of mice-

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The effect of Th1/Th2 dominance on the clinicopathological feature in murine model of IgA nephropathy

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第V因子を介した培養ヒトメサンギウム細胞上での凝固過程の検討Principal Investigator

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Cloning of genes expressing in the early stage of rat bladder carcinogenesis induced by BBNPrincipal Investigator

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[Book] 腎保護を意識した循環器薬の使い方.BEAMシリーズNo.1.循環器の基本薬を使いこなす2010

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[Book] 共著腎保護を意識した循環器薬の使い方BEAMシリーズNo.1.循環器の基本薬を使いこなす2010

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[Book] IgA腎症モデルマウス(HIGA)へのLPS投与による酸化ストレス・凝固系活性化を介した腎炎増悪. 腎とフリーラジカル第9集2008

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[Journal Article] Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by DDAH-ADMA-NO pathway2012

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[Journal Article] 慢性腎臓病(CKD)における凝固系と凝固第Xa因子の役割(Review)2012

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[Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice2011

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[Journal Article] Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice2011

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ONO Takahiko 小野孝彦

[Presentation] シンポジウム慢性腎臓病CKDと関連病態の漢方治療.高血圧を伴ったCKDに対する漢方治療の基礎と臨床2010