YOSHIMURA Kunihiko 吉村邦彦

Researcher Number	60246452
External Links
Affiliation (Current)	2022: (財)冲中記念成人病研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2008: Okinaka Memorial Institute for Medical Research, 研究員 2007: Okinaka Memorial Institute for Medical Research, 研究員 2005 – 2006: (財)冲中記念成人病研究所, 研究員 2004: 冲中記念成人病研究所, 研究員 2003 – 2004: Okinaka Memorial Institute for Medical Research, Researcher, 研究員 … More 1993 – 2002: 東京慈恵会医科大学, 医学部, 講師 1999: 東京慈恵会医科大学, 講師 1996: 東京慈恵会医科大学, DNA研遺伝子治療, 講師 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator 遺伝子発現 / gene expression / cDNA microarray / cystic fibrosis / IGF-1 / IGF-1受容体 / びまん性汎細気管支炎 / differential display / diffuse panbronchiolitis / promoter … More / CFTR / 遺伝子変異 / ΔF508 / mutagenesis / CD24 / 先端肥大症 / 悪性腫瘍 / 成長ホルモン / 肺癌 / 間脳下垂体 / 悪性種瘍 / 間脳下垂体外科 / IGF-I受容体 / cDNA microarry / 間質性肺炎 / 肺線維症 / 肺胞上皮細胞 / 肺線維芽細胞 / 乳酸脱水素酵素 / interstitial pneumonia / pulmonary fibrosis / alveolar epithelial cells / fibroblasts / lactate dehydrogenase / 気道上皮細胞 / CFTR遺伝子 / CC10遺伝子 / 嚢胞性線維症 / airway epithelium / CFTR gene / CC10 gene / 小細胞肺癌 / proGRP遺伝子 / GRP受容体遺伝子 / ニコチン / アセチルコリン受容体 / 遺伝子治療 / 肺小細胞癌 / small cell lung cancer / proGRP gene / GRP receptor gene / nicotine / acetylcholine receptor / gene therapy / マクロライド / macrolides / gene mutations / 細気管支肺胞上皮癌 / 同時多発性 / 高解像度CTスキャン / mRNA発現profiling / mRNA発現プロファイリング / p53 / 免疫組織化学 / bronchioloalveolar cell carcinoma / synchronous tumorigenesis / high resolution CT scan / insulin-like growth factor I (IGF-I) / IGF-I receptor / mRNA expression profiling … More Except Principal Investigator differential display / 肺気腫 / レチノイン酸 / 再生治療 / cDNA microarray法 / 肺胞微石症 / GeneChip / 常染色体劣性遺伝 / 近親婚 / いとこ婚 / SNP解析 / homozygosity mapping / founder gene effect / マクロライド / びまん性汎細気管支炎 / 気道上皮細胞 / 遺伝子発現 / β-defensin / differential desplay / βーdefensin / エリスロマイシン / 気道上皮 / サイトカイン / Differential display / macrolides / diffuse panbronchiolitis / airway epithelium / gene expression / beta-defensin / 肺癌 / FHIT遺伝子 / 遺伝子治療 / LUNG CANCER / FHIT GENE / GENE THERAPY Less

Molecular analysis for the pathogenesis of lung cancer associatedvwith acromegalyPrincipal Investigator
- Principal Investigator
  
  吉村邦彦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okinaka Memorial Institute for Medical Research
肺胞微石症の責任遺伝子同定に関する研究
- Principal Investigator
  
  萩原弘一
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Saitama Medical University
Clinical characteristics and molecular pathogenesis of synchronously-arisen multiple bronchioloalveolar carcinoma of the lungPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Kunihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okinaka Memorial Institute for Medical Research
肺胞再生の分子機序の解析による肺気腫症の再生治療の基礎的研究
- Principal Investigator
  
  AKOI Kaoru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Airway Inflammation due to the Mutated CFTR and Modulation with Macrolide AntibioticsPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Kunihiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okinaka Memorial Institute for Medical Research
  Jikei University School of Medicine
ADENOVIRAL TRANSFER OF FHIT GENE TO LUNG CANCER
- Principal Investigator
  
  KOJIMA Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  JIKEI UNIVERSITY SCHOOL OF MEDICINE
Molecular analysis of modulation for expression of pro-gastrin releasing peptide and gastrin releasing peptide receptor genes in lung epithelial cellsPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Kunihiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The Jikei University School of Medicine
Regulation of gene expression by macrolides in bronchial epithelial cells
- Principal Investigator
  
  TANABE Osamu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The Jikei University School of Medicine
Molecular pathogenesis of diffuse panbronchiolitis : Evaluation for expression of the airway epithelium-specific genesPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Kunihiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The Jikei University School of Medicine
Differential Expression of The Lactate Dehydrogenase-A and B Subunit Genes in Lung Cells in Interstitial Pneumonia and Pulmonary FibrosisPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Kunihiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The Jikei University School of Medicine

All 2008 2006 2005 2004 2003 2002

All Journal Article Presentation Book

[Book] あなたの家族が病気になった時に読む本「肺がん」(福井次矢, 川島みどり, 大熊由紀子)2006
- Author(s)
  吉村邦彦, 岸一馬, 高宮有介, 守田美奈子, 吉田みつ子, 大松重宏
- Total Pages
  190
- Publisher
  編集(講談社,東京)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Book] あなたの家族が病気になった時に読む本「肺がん」2006
- Author(s)
  吉村邦彦, 岸一馬, 高宮有介, 守田美奈子, 吉田みつ子, 大松重宏
- Total Pages
  190
- Publisher
  福井次矢, 川島みどり, 大熊由紀子編集(講談社,東京)
- Data Source
  KAKENHI-PROJECT-16590772
[Book] Annual Review 2003呼吸器:日本人におけるCFTRの遺伝子多型(工藤翔二, 土屋了介, 金澤実, 太田健編)2003
- Author(s)
  吉村邦彦
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] Multiple bronchioloalveolar carcinomas in acromegaly : a potential role of insulin-like growth factor I in carcinogenesis.2006
- Author(s)
  Motoi N, Kishi K, Fujii T, Tsuboi E, Ohashi K, Yoshimura K.
- Journal Title
  
  Lung Cancer 54
  
  Pages: 247-253
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] 細気管支肺胞上皮癌様の肺内進展を呈した悪性胸膜中皮腫の1例2006
- Author(s)
  杉野圭史, 川畑雅照, 本間栄, 河野匡, 元井紀子, 吉村邦彦
- Journal Title
  
  肺癌 46
  
  Pages: 215-220
- NAID
  110004741215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Multicenter phase I study of repeated intratumoral deliver) adenoviral p53 in patients with advanced non-small-cell lu cancer.2006
- Author(s)
  Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T, Yoshimura K, Sato T, Eto Y, Chada S, Nakamura H, Kato H.
- Journal Title
  
  J Clin Oncol 24
  
  Pages: 1689-1699
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] A clinical study of advanced large cell carcinoma.2006
- Author(s)
  Kishi K, Homma S, Takaya H, Miyamoto A, Sakamoto S, Kurosaki A, Motoi N, Yoshimura K.
- Journal Title
  
  Nippon Kokyuki Gakkai Zasshi 44
  
  Pages: 556-560
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] High-resolution computed tomography findings of lung cancer associated with idiopathic pulmonary fibrosis2006
- Author(s)
  Kishi, K, Homma S, Kurosaki A, Motoi N, Yoshimura K.
- Journal Title
  
  J Computer Assisted Tomography 30
  
  Pages: 95-99
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer2006
- Author(s)
  Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T, Yoshimura K, Sato T, Eto Y, Chada S, Nakamura H, Kato H.
- Journal Title
  
  J Clin Oncol 24
  
  Pages: 1689-1699
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Efficacy of gefitinib in a patient with lung cancer associated with idiopathic pulmonary fibrosis2006
- Author(s)
  Kishi K, Nakata K, Yoshimura K.
- Journal Title
  
  J Thorac Oncol 1
  
  Pages: 733-734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] 進行性大細胞神経内分泌癌の臨床的検討2006
- Author(s)
  岸一馬, 本間栄, 高谷久史, 宮本篤, 坂本晋, 黒崎敦子, 元井紀子, 吉村邦彦
- Journal Title
  
  日呼吸会誌 44
  
  Pages: 556-560
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] A case of malignant pleural mesothelioma mimicking bronchioloalveolar carcinoma in its intrapulmonary growth pattern.2006
- Author(s)
  Sugino K, Kawabata M, Homma S, Kohno T, Motoi N, Yoshimura K.
- Journal Title
  
  Haigan 46
  
  Pages: 215-220
- NAID
  110004741215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] High-resolution computed tomography findings of lung cancer ass ociated with idiopathic pulmonary fibrosis2006
- Author(s)
  Kishi, K, Homma S, Kurosaki A, Motoi N, Yoshimura K.
- Journal Title
  
  J Computer Assisted Tomography 30
  
  Pages: 95-99
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Efficacy of gefitinib in a patient with lung cancer associated with idiopathic pulmonary fibrosis.2006
- Author(s)
  Kishi K, Nakata K, Yoshimura K.
- Journal Title
  
  J Thorac Oncol 1
  
  Pages: 733-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] High-resolution computed tomography findings of lung cancer associated with idiopathic pulmonary fibrosis.2006
- Author(s)
  Kishi, K, Homma S, Kurosaki A, Motoi N, Yoshimura K.
- Journal Title
  
  J Computer Assisted Tomography 30
  
  Pages: 95-99
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Multiple bronchioloalveolar carcinomas in acromegaly : a potential role of insulin-like growth factor I in carcinogen2006
- Author(s)
  Motoi N, Kishi K, Fujii T, Tsuboi E, Ohashi K, Yoshimura K.
- Journal Title
  
  Lung Cancer 54
  
  Pages: 247-253
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Cyclosporin treatment in steroid-resistant and acutely exacerbated interstitial pneumonia2005
- Author(s)
  Homma S, Sakamoto S, Kawabata M, Kishi K, Tsuboi E, Miyamoto A, Motoi N, Yoshimura K.
- Journal Title
  
  Intern Med 44
  
  Pages: 1144-1150
- NAID
  10016885976
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Clinical features and high-resolution CT findings of pulmonary cryptococcosis in non-AIDS patients2005
- Author(s)
  Kishi, K, Homma S, Kurosaki A, Kohno T, Motoi N, Yoshimura K.
- Journal Title
  
  Respir Med 100
  
  Pages: 807-812
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide2005
- Author(s)
  Homma S, Miyamoto A, Sakamoto S, Kishi K, Motoi N, Yoshimura K.
- Journal Title
  
  Eur Respir J 25
  
  Pages: 200-204
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Small lung tumors with the size of one centimeter or less in diameter : clinical, radiological and histopathological characteristics2004
- Author(s)
  Kishi K, Homma S, Kurosaki A, Motoi N, Kohno T, Nakata K, Yoshimura K
- Journal Title
  
  Lung Cancer 44
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] Efficacious pleurodesis with OK-432 and doxorubicine against malignant pleural effusions2004
- Author(s)
  Kishi K, Homma S, Sakamoto S, Kawabata M, Tsuboi E, Nakata K, Yoshimura K
- Journal Title
  
  Eur Respir J 24
  
  Pages: 263-266
- Data Source
  KAKENHI-PROJECT-16590772
[Journal Article] CFTRに対するマクロライドの作用の分子生物学的検討2003
- Author(s)
  吉村邦彦, ほか
- Journal Title
  
  Jpn J Antibiotics 56-suppl
  
  Pages: 117-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] High prevalence of mutations of the CFTR gene in Japanese individuals with congenital bilateral absence of the vas deferens2003
- Author(s)
  Anzai C, Yoshimura K, et al.
- Journal Title
  
  J Cystic Fibrosis 2-1
  
  Pages: 14-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] 日本人cystic fibrosis患者におけるCFTR遺伝子変異解析2003
- Author(s)
  吉村邦彦
- Journal Title
  
  厚生労働省特定疾患対策研究事業「難治性膵疾患に関する調査研究班」平成14年度研究報告書
  
  Pages: 213-216
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] Molecular mechanisms of effects of macrolide antibiotics on CFTR (in Japanese)2003
- Author(s)
  Yoshimura K et al.
- Journal Title
  
  Jpn J Antibiotics 56
  
  Pages: 117-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] DPBの治療反応性とCFTR遺伝子変異2002
- Author(s)
  吉村邦彦
- Journal Title
  
  Therapeutic Research 23-9
  
  Pages: 1825-1828
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] わが国の嚢胞性線維症におけるCFTR遺伝子の解析2002
- Author(s)
  吉村邦彦, ほか
- Journal Title
  
  厚生労働省特定疾患対策研究事業「難治性膵疾患に関する調査研究班」平成13年度研究報告書
  
  Pages: 111-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Journal Article] CFTR gene mutations and modulation with macrolide antibiotics (in Japanese)2002
- Author(s)
  Yoshimura K
- Journal Title
  
  Therapeutic Research 23
  
  Pages: 1825-1828
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13670619
[Presentation] Microarray Profiling Analysis in Multiple and Synchronous Lung Adeno-carcinomas2008
- Author(s)
  Yoshimura K, Fujii T, Uruga H, Miyamoto A, Takaya H, Enomoto T, Morokawa N, Kishi K
- Organizer
  American Thoracic Society 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590922
[Presentation] Microarray profiling analysis in multiple and synchronous lung adenocarcinomas2008
- Author(s)
  Yoshimura K, Fujii T, Uruga H, Miyamoto A, Takaya H, Enomoto T, Morokawa N, Kishi K
- Organizer
  American Thoracic Society 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590922

1. AKOI Kaoru (90212357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KISHI Kazuma (80425438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
3. KOJIMA Akira (60256378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TANABE Osamu (20236657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TSUCHIYA Masashi (20236912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 萩原弘一 (00240705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金沢実 (80118934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤井丈士 (70228948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 山田正三 (80260131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 工藤宏一郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. GHANSHYAM D.Heda

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HEDA Ghanshyam D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIMURA Kunihiko 吉村 邦彦

Research Projects

Research Products

Co-Researchers

Molecular analysis for the pathogenesis of lung cancer associatedvwith acromegalyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺胞微石症の責任遺伝子同定に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical characteristics and molecular pathogenesis of synchronously-arisen multiple bronchioloalveolar carcinoma of the lungPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺胞再生の分子機序の解析による肺気腫症の再生治療の基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Airway Inflammation due to the Mutated CFTR and Modulation with Macrolide AntibioticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ADENOVIRAL TRANSFER OF FHIT GENE TO LUNG CANCER

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of modulation for expression of pro-gastrin releasing peptide and gastrin releasing peptide receptor genes in lung epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of gene expression by macrolides in bronchial epithelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathogenesis of diffuse panbronchiolitis : Evaluation for expression of the airway epithelium-specific genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Differential Expression of The Lactate Dehydrogenase-A and B Subunit Genes in Lung Cells in Interstitial Pneumonia and Pulmonary FibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] あなたの家族が病気になった時に読む本「肺がん」(福井次矢, 川島みどり, 大熊由紀子)2006

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] あなたの家族が病気になった時に読む本「肺がん」2006

Author(s)

Total Pages

Publisher

Data Source

[Book] Annual Review 2003呼吸器:日本人におけるCFTRの遺伝子多型(工藤翔二, 土屋了介, 金澤 実, 太田 健編)2003

Author(s)

Publisher

Description

Data Source

YOSHIMURA Kunihiko 吉村邦彦

[Book] Annual Review 2003呼吸器:日本人におけるCFTRの遺伝子多型(工藤翔二, 土屋了介, 金澤実, 太田健編)2003