Okumura Nobuo 奥村伸生

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OKUMURA Nobuo 奥村伸生

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Researcher Number	60252110
Other IDs
Affiliation (Current)	2025: 地方独立行政法人長野県立病院機構長野県立こども病院(生命科学研究センター), 生命科学研究センター, 主任研究員 2025: 信州大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2023: 信州大学, 医学部, 特任教授 2021 – 2022: 信州大学, 学術研究院保健学系, 特任教授 2014 – 2020: 信州大学, 学術研究院保健学系, 教授 2015: 信州大学, 医学部, 教授 2010 – 2013: 信州大学, 医学部, 教授 2004 – 2008: 信州大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Laboratory medicine / Basic Section 52010:General internal medicine-related Except Principal Investigator Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords	Principal Investigator フィブリノゲン / フィブリン / MMP-3 / 関節リウマチ / フィブリン重合反応 / NETs / 形質転換能 / 遊走能 / 皮膚線維芽細胞 / 血管内皮細胞 … More / THP-1 / M1-マクロファージ / NETｓ形成能 / 好中球 / NETs形成能 / 内皮間葉転換能 / 細胞遊走能 / アミロイドβ1-42 / M1-Mφ分化 / 管状構造形成能 / 異常フィブリノゲン / 臨床検査 / 遺伝子変異 / 蛋白質機能異常 / 血液凝固 / IgA-λ型Ｍタンパク / 出血 / 血栓症 / フィブリノゲン機能異常症 / トロンビン / B:b結合 / A:a結合 / D:D結合能部位 / Ca結合部位 / aホール / secretion / assembly / tertiary structure / Bβ-chain / γ-chain / fibrinogen / フィビリノゲン / 分泌 / 組み立て / 立体構造 / Bβ鎖 / γ鎖 / HuH細胞 / CHO細胞 / 細胞内封入体 / 肝小胞体蓄積病 / フィブリノゲン異常症 / オートファジー促進剤 / アポトーシス促進剤 / オートファジー阻害剤 / プロテアソーム阻害剤 / 蛍光抗体法 / 粗面小胞体 / 細胞質封入体 / フィブリノゲン蓄積症 / フィブリノゲン低下症 / 好中球エラスターゼ / プラスミン / 蛋白分解酵素 / キマーゼ / エラスターゼ / 抗シトルリン化蛋白抗体 / シトルリン化 / 臨床血液学 / フィブリン架橋反応 / フィブリノペプチド放出反応 / 生理活性 / 酵素 / 蛋白質 / PAI-1 / IL-6 / TNFa / シトルリン化フィブリン / シトルリン化フィブリノゲン … More Except Principal Investigator シトルリン化フィブリノゲン / 炎症 / 好中球 / PAD4 / がん / 感染症 / PAD / NETs / 好中球細胞外トラップ / ストレプトアビジン-POD / ビオチン化抗ヒトIgG / 至適条件 / 血中抗体濃度 / 血中抗原濃度 / 関節リウマチ / ELISA / TFF / mucin / 粘液 / 膵腫瘍 / 膵管内乳頭粘液性腫瘍 Less

シトルリン化フィブリノゲンの好中球エフェクター機能に及ぼす影響
- Principal Investigator
  
  樋口由美子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residuesPrincipal Investigator
- Principal Investigator
  
  Okumura Nobuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Detection of neutrophil extracellular traps by measuring citrullinated fibrinogen in serum
- Principal Investigator
  
  Higuchi Yumiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Shinshu University
Mechanisms of fibrin polymerization based on analysis for dysfunctional fibrinogen variantsPrincipal Investigator
- Principal Investigator
  
  Okumura Nobuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University
Diagnosis and molecular mechanisms for hypofibrinogenemia inducing liver cirrhosisPrincipal Investigator
- Principal Investigator
  
  OKUMURA Nobuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University
Measurement of the plasma and synovia levels of citrullinated fibrinogen and antibodies against it in rheumatoid arthritis patients
- Principal Investigator
  
  Terasawa Fumiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hokuriku University
  Shinshu University
Clinicopathological study on adenocarcinoma of gastric phenotype and its precursor lesion
- Principal Investigator
  
  OTA Hiroyoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University
Research on solubilization of citrullinated fibrinogen and fibrinPrincipal Investigator
- Principal Investigator
  
  OKUMURA Nobuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University
Studies for coagulation and fibrinolysis of citrullinated fibrinogen and its association with pathophysiology in Rheumatoid ArthritisPrincipal Investigator
- Principal Investigator
  
  OKUMURA Nobuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Shinshu University
Studies for the tertiary structure of Bβ-and γ-chain that are important for assembly and/or secretion of fibrinogen.Principal Investigator
- Principal Investigator
  
  OKUMURA Nobuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  SHINSHU UNIVERSITY

All 2023 2022 2021 2020 2019 2018 2017 2015 2012 2011 2009 2008 2006 2005 Other

All Journal Article Presentation

[Journal Article] Laboratory diagnosis of fibrinogen disorder using clot waveform analysis2023
- Author(s)
  新井慎平、奥村伸生
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 34 Issue: 1 Pages: 22-28
- DOI
  10.2491/jjsth.34.22
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] Screening method for congenital dysfibrinogenemia and hypodysfibrinogenemia using clot waveform analysis with the Clauss method2021
- Author(s)
  Arai S, Kamijo T, Hayashi F, Shinohara S, Arai N, Sugano M, Uehara T, Honda T, Okumura N.
- Journal Title
  
  Int J Lab Hematol
  
  Volume: 43 Issue: 2 Pages: 281-289
- DOI
  10.1111/ijlh.13358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K15945
[Journal Article] Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy2021
- Author(s)
  Niwa K, Nagata K, Nakagami T, Shimaoka R, Niwa K, Takenaka M, Tanaka K, Okumura N.
- Journal Title
  
  Case Reports in Clinical Medicine
  
  Volume: 10 Issue: 04 Pages: 108-116
- DOI
  10.4236/crcm.2021.104013
- NAID
  120007180884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] A novel homozygous variant of the thrombomodulin gene causes a hereditary bleeding disorder2021
- Author(s)
  Osada M, Maruyama K, Kokame K, Denda R, Yamazaki K, Kunieda H, Hirao M, Madoiwa S, Okumura N, Murata M, Ikeda Y, Watanabe K, Tsukada Y, Kikuchi T
- Journal Title
  
  Blood Advance
  
  Volume: 5 Issue: 19 Pages: 3830-3838
- DOI
  10.1182/bloodadvances.2020003814
- NAID
  120007180883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-20K16568
[Journal Article] Automated screening procedure for phenotype of congenital fibrinogen disorder using novel parameters, |min1|c and Ac/|min1|c obtained from clot waveform analysis of Clauss method2021
- Author(s)
  Arai S, Kamijo T, Kaido T, Yoda M, Shinohara S, Suzuki T, Arai N, Sugano M, Uehara T, Okumura N.
- Journal Title
  
  Clinica Chimica ACTA
  
  Volume: 521 Pages: 170-176
- DOI
  10.1016/j.cca.2021.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K15945
[Journal Article] Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB gene.2021
- Author(s)
  Shinozuka J, Okumura N, Nagasawa M, Nishikado M, Kadowaki S, Katsuda I, Imashuku S.
- Journal Title
  
  Pediatric Reports
  
  Volume: 13 Issue: 1 Pages: 113-117
- DOI
  10.3390/pediatric13010016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] A novel variant fibrinogen, AαE11del, demonstrating the important of AαE11 residue in thrombin binding2021
- Author(s)
  Kaido T, Yoda M, Kamijo T, Arai S, Yamauchi K, Okumura N
- Journal Title
  
  Int J Hematology
  
  Volume: 114 Issue: 5 Pages: 591-598
- DOI
  10.1007/s12185-021-03200-z
- NAID
  120007180889
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K07310, KAKENHI-PROJECT-21K15945
[Journal Article] 28年間で解析した長野県内のフィブリノゲン異常症18家系28例2021
- Author(s)
  上條途夢，海藤貴大, 依田将宏, 平千明,　樋口由美子，新井慎平,　竹澤由夏，奥村伸生．
- Journal Title
  
  長臨技会誌
  
  Volume: 10 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] Novel variant fibrinogen γ p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment2021
- Author(s)
  Yoda M, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Int J Hematology
  
  Volume: 114 Issue: 3 Pages: 325-333
- DOI
  10.1007/s12185-021-03174-y
- NAID
  120007180888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K15945
[Journal Article] Changes in serum citrullinated fibrinogen concentration associated with the phase of bacteremia patients.2021
- Author(s)
  Fujimura S, Higuchi Y, Usami Y, Yamaura M, Higuchi T, Terasawa F, Okumura N.
- Journal Title
  
  Clin Chim Acta .
  
  Volume: 512 Pages: 127-134
- DOI
  10.1016/j.cca.2020.10.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07822, KAKENHI-PROJECT-20K07799
[Journal Article] Recombinant γY278H fibrinogen shows normal secretion from CHO cells, but a corresponding heterozygous patient showed hypofibrinogenemia2021
- Author(s)
  KamijoT, Kaido T, Yoda M, Arai S, Yamauchi K, Okumura N.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 10 Pages: 5218-5218
- DOI
  10.3390/ijms22105218
- NAID
  120007180886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799, KAKENHI-PROJECT-21K07310, KAKENHI-PROJECT-21K15945
[Journal Article] The heterozygous variant fibrinogen, γA289V (Kanazawa III), was confirmed as hypodysfibrinogenemia by plasma and recombinant fibrinogens2020
- Author(s)
  Kaido T, Yoda M, KamijoT, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Int J Lab Hematol
  
  Volume: 42 Issue: 2 Pages: 190-197
- DOI
  10.1111/ijlh.13152
- NAID
  120007099524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Acquired dysfibrinogenemia: monoclonal λ-type IgA binding to fibrinogen caused lower functional plasma fibrinogen level and abnormal clot formation2020
- Author(s)
  Arai S, Kamijo T, Takezawa Y, Sugano M, Nakazawa H, Yanagisawa R, Uehara T, Honda T, Okumura N.
- Journal Title
  
  Int J Hematol
  
  Volume: 111 Issue: 1 Pages: 96-104
- DOI
  10.1007/s12185-020-02874-1
- NAID
  120007180894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Congenital fibrinogen disorder with a compound heterozygote possessing two novel FGB mutations, one qualitative and the other quantitative2020
- Author(s)
  Yoda M, Kaido T, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 196 Pages: 152-158
- DOI
  10.1016/j.thromres.2020.08.031
- NAID
  120007180892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] A novel amino acid substitution, fibrinogen Bβp.Pro234Leu, associated with hypofibrinogenemia causing impairment of fibrinogen assembly and secretion2020
- Author(s)
  Kaido T, Yoda M, Kamijo T, Arai S, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9422-9422
- DOI
  10.3390/ijms21249422
- NAID
  120007180887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07799
[Journal Article] γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal2019
- Author(s)
  KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 182 Pages: 150-158
- DOI
  10.1016/j.thromres.2019.08.017
- NAID
  120007180893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] フィブリノゲン蓄積病を呈する異常フィブリノゲン産生細胞の線維状封入体形成と小胞体ストレス応答2018
- Author(s)
  上條途夢，大久保奈緒，平千明，樋口由美子，新井慎平，奥村伸生
- Journal Title
  
  臨床病理
  
  Volume: 66 Pages: 1058-1064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] DVTを発症した先天性フィブリノゲン異常症患者Fibrinogen Matsumoto I のFDP-E分画異常高値の精査2018
- Author(s)
  新井慎平，中越りつこ，倉田淳一，川崎健治，菅野光俊，上原剛，本田孝行，奥村伸生
- Journal Title
  
  検査血液
  
  Volume: 19 Pages: 306-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization2018
- Author(s)
  Kamijo T, Nagata K, Taira C, Higuchi Y, Arai S, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 172 Pages: 1-3
- DOI
  10.1016/j.thromres.2018.10.004
- NAID
  120007099533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] ファクターオートフィブリノーゲンの基礎的性能評価とフィブリノーゲン異常症例における測定値の検討2018
- Author(s)
  永田和宏，新井慎平，向井早紀，竹澤由夏，菅野光俊，本田孝行，奥村伸生．
- Journal Title
  
  医学検査
  
  Volume: 67 Pages: 7-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Hereditary Fibrinogen Aα-Chain Amyloidosis in Asia: Clinical and Molecular Characteristics2018
- Author(s)
  Yazaki M、Yoshinaga T、Sekijima Y、Kametani F、Okumura N
- Journal Title
  
  Int J Mol Sci
  
  Volume: 19 Issue: 1 Pages: 320-320
- DOI
  10.3390/ijms19010320
- NAID
  120007099523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08739, KAKENHI-PROJECT-16K21066, KAKENHI-PROJECT-17K09009
[Journal Article] A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia2017
- Author(s)
  Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N.
- Journal Title
  
  Thromb Res
  
  Volume: 159 Pages: 82-85
- DOI
  10.1016/j.thromres.2017.10.002
- NAID
  120007099532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] The fibrous form of intracellular inclusion bodies in recombinant variant fibrinogen-producing cells is specific to hepatic fibrinogen storage disease-inducible variant fibrinogen2017
- Author(s)
  Shinpei Arai, Naoko Ogiwara, Saki Mukai, Yuka Takezawa, Mitsutoshi Sugano, Takayuki Honda, Nobuo Okumura
- Journal Title
  
  International Journal of Hematology
  
  Volume: 105 Issue: 6 Pages: 1-11
- DOI
  10.1007/s12185-017-2185-5
- NAID
  120007099521
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460672
[Journal Article] A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia2017
- Author(s)
  Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Issue: 11 Pages: 2470-2470
- DOI
  10.3390/ijms18112470
- NAID
  120007099522
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09009
[Journal Article] Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin2009
- Author(s)
  Nobuo Okumura, Ayumi Haneishi, Fumiko Terasawa
- Journal Title
  
  Clinica Chimica Acta 401
  
  Pages: 119-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590551
[Journal Article] 変異フィブリノゲンKyoto IV(Bβ鎖コイルドコイル領域SerIII欠損)の発見と文献的考察2006
- Author(s)
  中西加代子, 森尚子, 石田敦巳, 藤井葉子, 志賀修一, 斎藤潤, 奥村伸生, 一山智
- Journal Title
  
  日本検査血液学会雑誌 7
  
  Pages: 394-400
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] A novel variant fibrinogen, deletion of Bβ111Ser in coiled-coil region, affecting fibrin lateral aggregation,2006
- Author(s)
  Nobuo Okumura
- Journal Title
  
  Clinica Chimica Acta 365
  
  Pages: 160-167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] A novel variant fibrinogen, deletion of Bβ111Ser in coiled-coil region, affecting fibrin lateral aggregation2006
- Author(s)
  Nobuo Okumura
- Journal Title
  
  Clinica Chimica Acta 365
  
  Pages: 160-167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] In vitro clot formation and fibrinolysis using heterozygous plasma fibrinogen from γAsn319,Asp320 deletion dysfibrinogen, Otsu I2006
- Author(s)
  Fumiko Terasawa, Satomi Kani, Minoru Hongo, Nobuo Okumura
- Journal Title
  
  Thrombosis Research 118
  
  Pages: 651-661
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] A novel variant fibrinogen, deletion of BβIIISer in coiled-coil region, affecting fibrin lateral aggregation2006
- Author(s)
  Nobuo Okumura, Fumiko Terasawa, Masako Hirota-Kawadobora, 他
- Journal Title
  
  Clinica Chimica Acta 365
  
  Pages: 160-167
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] Analysis of fibrinogen γ387Ile shows that the side chain of γ387 and the tertiary structure of the γC-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed γ-γ dimer formation2006
- Author(s)
  Satomi Kani, Fumiko Terasawa, Kazuyoshi Yamauchi, Minoru Tozuka, Nobuo Okumura
- Journal Title
  
  Blood 108
  
  Pages: 1887-1894
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] Residue γ153Cys is essential for the formation of the complexes Aαγ and Bβγ, assembly intermediates for the AαBβγ complex2005
- Author(s)
  F.Terasawa, K.Fujita, N.Okumura
- Journal Title
  
  Clinica Chimica Acta 353
  
  Pages: 157-164
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] In vitro expression demonstrates impaired secretion of the γAsn319,Asp320 deletion variant fibrinogen2005
- Author(s)
  Satomo Kani, Fumiko Terasawa, Susan T Lord, Minoru Tozuka, Hiroyoshi Ota, Nobuo Okumura, Tsutomu Katsuyama
- Journal Title
  
  Thrombosis and Haemostasis 94
  
  Pages: 53-59
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] Functional analysis of recombinant Bβ15C and Bβ15A fibrinogens demonstrates that Bβ15G residue plays important roles in FPB release and in lateral aggregation of protofibrils2005
- Author(s)
  M Hirota-Kawadobora, S Kani, F Terasawa, K Yamauchi, M Tozuka, N Okumura
- Journal Title
  
  Journal of Thrombosis and Haemostasis 3
  
  Pages: 983-990
- Data Source
  KAKENHI-PROJECT-16590451
[Journal Article] Residues γ153Cys is essential for the formation of the complexes Aαγ and Bβγ, assembly intermediates for AαBβγ complex and intact fibrinogen2005
- Author(s)
  Fumiko Terasawa, Kiyotaka Fujita, Nobuo Okumura
- Journal Title
  
  Clinica Chimica Acta 353
  
  Pages: 157-164
- Data Source
  KAKENHI-PROJECT-16590451
[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022
- Author(s)
  Tsubasa Sue, Tomoki Ichikawa, Satoshi Fujimura, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022
- Author(s)
  Tomoki Ichikawa, Tsubasa Sue, Satoshi Fujimura, Yoko Usami, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] Validation of a sandwich enzyme-linked immunosorbent assay to determine serum citrullinated fibrinogen concentration2022
- Author(s)
  omoki Ichikawa, Tsubasa Sue, Satoshi Fujimura, Yoko Usami, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] Citrullinated fibrinogen for detection of neutrophil extracellular traps2022
- Author(s)
  Tsubasa Sue, Tomoki Ichikawa, Satoshi Fujimura, Tsukasa Higuchi, Nobuo Okumura, Yumiko Higuchi
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] Novel approach for the phenotypes of congenital fibrinogen disorders using alternative fibrinogen value, |min1|c, obtained from clot waveform analysis2022
- Author(s)
  Shinpei Arai, Tomu Kamijo, Takahiro Kaido, Sho Shinohara, Takeshi Suzuki, Nobuo Arai, Takeshi Uehara, Nobuo Okumura
- Organizer
  The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] 乾燥人フィブリノゲン製剤の継続輸注で着床・妊娠継続・出産をし得た先天性低フィブリノゲン血症2021
- Author(s)
  関　義信, 牛木隆志, 増子正義，瀧澤　淳，曽根博仁，奥村伸生
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] フィブリノゲンにおけるアミノ酸変異BβP204Lとフィブリノゲン低下症の関係2021
- Author(s)
  海藤貴大，上條途夢，平　千明，山内一由，奥村伸生
- Organizer
  第61回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] 菌血症患者における血清中シトルリン化フィブリノゲンと炎症マーカーの関連2021
- Author(s)
  藤村哲士，樋口由美子，宇佐美陽子，山浦　洵，樋口　司，寺澤文子，奥村伸生
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07799
[Presentation] 急性大動脈解離におけるシトルリン化フィブリノゲンの動態2021
- Author(s)
  藤村哲士、樋口由美子、伊澤淳、宇佐美陽子、山浦洵、奥村伸生
- Organizer
  第67回　日本臨床検査医学会　学術集会
- Data Source
  KAKENHI-PROJECT-20K07822
[Presentation] γG287～G292領域のアミノ酸置換（特にγA289V　KanazawaIII）によるフィブリノゲン合成と分泌に対する影響する2019
- Author(s)
  海藤貴大，依田将大，上條途夢，平　千明，奥村伸生
- Organizer
  第59回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] FGG c.112+62_65 del AATAとFGG c.1299+4 del Aのコンパウンドヘテロ型フィブリノゲン異常症Tsukuba Iの解析2019
- Author(s)
  向井早紀，新井慎平，竹澤由夏，菅野光俊，本田孝行，奥村伸生
- Organizer
  第20回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] PT-derived法と凝固反応曲線変化量dHによるフィブリノゲン異常症検出法の検討2019
- Author(s)
  新井慎平，上條途夢，篠原　翔，新井信夫，菅野光俊，柳沢　龍，上原　剛，本田孝行，奥村伸生
- Organizer
  第20回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 変異型フィブリノゲンBβ44Arg->Cysがフィブリノゲン重合反応に与える影響の検討2019
- Author(s)
  海藤貴大，依田将大，上條途夢，平　千明，樋口由美子，新井慎平，竹澤由夏，奥村伸生
- Organizer
  第44回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 無フィブリノゲン血症を疑い遺伝子検査を実施した重度DIC患者の1例2019
- Author(s)
  依田将大，海藤貴大，上條途夢，平　千明，塚田唯子，奥村伸生
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] フィブリンに全く転換できないリコンビナントフィブリノゲンγD318Yの機能解析2019
- Author(s)
  上條途夢，依田将大，海藤貴大，平　千明，奥村伸生
- Organizer
  第66回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 27年間で認められた長野県内のフィブリノゲン異常症17家系27症例の解析2019
- Author(s)
  上條途夢，海藤貴大，依田将大，平　千明，樋口由美子，新井慎平，竹澤由夏，奥村伸生
- Organizer
  第44回長野県臨床検査学会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] Residues　in　the　fibrinogen　γD-module　are　essential　for　fibrinogen　secretion　and　fibrin　polymerization using hole ‘a’ or hole ‘b’.2019
- Author(s)
  Kamijo T, Mukai S, Taira C, Higuchi Y, Okumura N
- Organizer
  The 57th Congress of the Korean Association of Medical Technologists and International Conference
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] フィブリノゲン蓄積病を呈するフィブリノゲン低下症型フィブリノゲン産生細胞の小胞体ストレスの研究2018
- Author(s)
  上條途夢，大久保奈緒，平　千明，奥村伸生
- Organizer
  第58回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 血栓形成性異常フィブリノゲン(Shizuoka)のトロンビンによる凝固関連機能の解析2018
- Author(s)
  上條途夢，平　千明，樋口由美子，新井慎平，奥村伸生
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] FGA1238bp欠失を有する無フィブリノゲン血症2例のハプロタイプ解析2018
- Author(s)
  平　千明，上條途夢，菅野光俊，奥村伸生
- Organizer
  第58回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 自動分析装置による測定でフィブリノゲン活性値の偽低値と異常凝固波形を示したIgA Mタンパク症例の解析2018
- Author(s)
  新井慎平，上條途夢，竹澤由夏，川崎健治，菅野光俊，本田孝行，奥村伸生
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] Production and biochemical analysis of mutated fibrinogen Aα produced by CHO cells with D523AGTC in FGA Japan original mutation.2018
- Author(s)
  Yoshinaga T, Yazaki　M, Sekijima Y, Kametani F, Okumura N
- Organizer
  The XVI International Symposium on Amyloidosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] 新規遺伝子変異を有する先天性フィブリノゲン低下症の分子生物学的解析2017
- Author(s)
  平　千明，菅野光俊，奥村伸生
- Organizer
  第57回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] Analysis of acquired dysfibrinogenemia caused by IgA monoclonal gammopathy with anaphylactoid purpura2017
- Author(s)
  Arai S, Takezawa Y, Mukai S, Nakagoshi R, Miyazaki A, Ishimine N, Kawasaki K, Taira C, Sugano M, Honda T, Okumura N
- Organizer
  29 th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09009
[Presentation] γR375Wフィブリノゲン産生CHO細胞における封入体形成性と低フィブリノゲン血症におけるHERSDの検索2015
- Author(s)
  新井慎平，向井早紀，菅野光俊，本田孝行，奥村伸生
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  岐阜市　長良川国際会議場
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26460672
[Presentation] Screening method for hepatic fibrinogen storage disease associated with congenital hypofibrinogenemia2015
- Author(s)
  Arai S, Mukai S, Takezawa Y, Sugano M, Honda T, Okumura N
- Organizer
  57 th ASH Annual Meeting
- Place of Presentation
  オーランド（米国フロリダ州）　オレンジ郡会議センター
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460672
[Presentation] 抗シトルリン化蛋白抗体と反応させたシトルリン化フィブリンの各種プロテアーゼによる分解性の検討2012
- Author(s)
  奥村伸生,寺澤文子
- Organizer
  第52回日本臨床化学会年次学術集会
- Place of Presentation
  盛岡市
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22590521
[Presentation] 関節リウマチ患者関節に認められるシトルリン化フィブリンのプロテアーゼによる分解性の検討2011
- Author(s)
  南谷真衣,寺澤文子,奥村伸生
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山市
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22590521
[Presentation] 関節リウマチ患者関節に認められるシトルリン化フィブリンのプロテアーゼによる分解性の検討2011
- Author(s)
  南谷真衣、寺沢文子、奥村伸生
- Organizer
  第58回日本臨床検査医学会学術集会
- Place of Presentation
  岡山コンベンションセンター(岡山市)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22590521
[Presentation] Functional analysis for citrullinated recombinant fibrinogen2008
- Author(s)
  Nobuo Okumura, Ayumi Haneishi, Fumiko Terasawa
- Organizer
  The XX^<th> International Fibrinogen Workshop
- Place of Presentation
  イタリア・ベニス
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19590551
[Presentation] Functional analysis for citrullinated recombinant fibrinogen2008
- Author(s)
  Nobuo Okumura, Ayumi Haneishi, Fumiko Terasawa
- Organizer
  The XX^<th> International Fibrinogen Workshop
- Place of Presentation
  イタリア・ペニス
- Data Source
  KAKENHI-PROJECT-19590551
[Presentation] HERSD型遺伝子変異を有する変異フィブリノゲン/γ鎖産生細胞の作製と封入体形成の検討
- Author(s)
  新井慎平，池田み奈美，小林玉宜，菅野光俊，本田孝行，寺澤文子，奥村伸生
- Organizer
  第61回日本臨床検査医学会学術集会
- Place of Presentation
  福岡市福岡国際会議場
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-26460672

1. FUMIKO Terasawa (40109210)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. Higuchi Yumiko (40757241)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 平千明 (40779310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
4. 新井慎平 (70866053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. OTA Hiroyoshi (50273107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HONDA Takayuki (80238815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石井亘 (80452142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 矢崎正英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okumura Nobuo 奥村 伸生

OKUMURA Nobuo 奥村 伸生

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シトルリン化フィブリノゲンの好中球エフェクター機能に及ぼす影響

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Evaluation for extra-cellular function of dysfunctional fibrinogen and identification of its important residuesPrincipal Investigator

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Detection of neutrophil extracellular traps by measuring citrullinated fibrinogen in serum

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Mechanisms of fibrin polymerization based on analysis for dysfunctional fibrinogen variantsPrincipal Investigator

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Diagnosis and molecular mechanisms for hypofibrinogenemia inducing liver cirrhosisPrincipal Investigator

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Measurement of the plasma and synovia levels of citrullinated fibrinogen and antibodies against it in rheumatoid arthritis patients

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Clinicopathological study on adenocarcinoma of gastric phenotype and its precursor lesion

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Research on solubilization of citrullinated fibrinogen and fibrinPrincipal Investigator

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Studies for coagulation and fibrinolysis of citrullinated fibrinogen and its association with pathophysiology in Rheumatoid ArthritisPrincipal Investigator

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Studies for the tertiary structure of Bβ-and γ-chain that are important for assembly and/or secretion of fibrinogen.Principal Investigator

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[Journal Article] Laboratory diagnosis of fibrinogen disorder using clot waveform analysis2023

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[Journal Article] Screening method for congenital dysfibrinogenemia and hypodysfibrinogenemia using clot waveform analysis with the Clauss method2021

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[Journal Article] Congenital Dysfibrinogenemia Presented with Massive Hematomas Formed after Hysterectomy2021

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Okumura Nobuo 奥村伸生

OKUMURA Nobuo 奥村伸生