Ikai Iwao 猪飼伊和夫

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IKAI Iwao 猪飼伊和夫

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Researcher Number	60263084
Other IDs
External Links
Affiliation (Current)	2025: 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 特別研究員
Affiliation (based on the past Project Information) *help	2009 – 2010: Kyoto University, 医学研究科, 非常勤講師 2007 – 2010: Kyoto University, school of Medicine, Associate Professor 2005 – 2006: Kyoto University Graduate School of Medicine, associate Professor, 医学研究科, 助教授 1996 – 2005: Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 1999: 京都大学, 大学院・医学研究科, 講師 1995 – 1996: Assistant, Kyoto University, 医学研究科, 助手
Review Section/Research Field	Principal Investigator General surgery / Digestive surgery / Digestive surgery / General surgery Except Principal Investigator Digestive surgery / Digestive surgery / General surgery / Radiation science / General surgery
Keywords	Principal Investigator 人工肝臓 / 肝幹細胞 / 拒絶反応 / hDAF / Transgenic pig / 遺伝子導入ブタ / Bioreactor / Functional evaluation / Bioartificial liver / ブタ肝細胞培養 … More / バイオリアクター / 機能評価 / Complement / Kupffer cell / 異種免疫反応 / 補体 / Kupffer細胞 / 体外灌流 / 肝臓外科学 / 細胞移植 / 肝細胞 / ヒトES細胞 / 癌幹細胞 / 分化誘導 / フローサイトメトリー / 間葉系細胞 / 肝前駆細胞 / FKBP12 / hepatic surgery / hepatocytes / human ES cells / cell transplantation / TRECK mouse / Cell transplantation therapy / ES cells / Hepatic stem cells / TRECKマウス / 細胞移植治療 / ES細胞 / mesenchymal cell / non-parenchymal cell / hepatic progenitor cell / tissue reconstruction / human liver / hepatic stem cell / コラーゲンタイプIシート / 類肝組織構築 / 共培養 / 1型コラーゲンシート / ヒト小型肝細胞 / 非実質細胞 / 組織再構築 / ヒト肝組織 / Liver / Xenoperfusion / リンパ球表面抗原 / 異種反応性自然抗体 / 溶血 / 補体抑制蛋白 / 肝臓 / 異種灌流 / 肝細胞機能 / Porcine hepatrocyte / Human hepatocyte / ヒト肝細胞培養 / ハイブリッド型人工肝臓 / ブタ肝細胞 / ヒト肝細胞 / Gadolinium chloride / Xenotransplantation / Extracorporeal perfusion / Artificial liver / 可溶性1型補体受容体 / サイトカイン / 異種肝灌流 / 補体制御因子 / 塩化ガドリニウム / 異種移植 / セルソーター / 遺伝子導入 / 初期発生 / 薬剤耐性 / 腫瘍形成能 / ヒトiPS細胞 / 胆管細胞癌 / 肝細胞癌 / 未分化状態維持 / 未分化維持 / 胆管前駆細胞 / Alloreactive antibody / 二次的リンパ組織 / 抗asialo GM1抗体 / CD8^+asialo GM1^+ T細胞 / alyマウス / 抗原提示 / 同種皮膚移植 / 二次リンパ組織 / epitope / SLE / 坑FKBP12自己抗体 / ピロリン酸 / inorganic pyrophosphatase / FK506 / 自己免疫疾患 / 生体部分肝移植 / 抗FKBP12自己抗体 / 自己抗体 / 肝移植 / ELISA / acute cellular rejection / liver transplantation / plasma FKBP12 / FK 506 / FK binding protein12(FKBP12) … More Except Principal Investigator LOH / SIAH1 / 肝細胞癌 / PEG10 / TaqMan PCR / liver tumor / radiofrequency / Tumor ablation / caspase-12 / bile duct ligation / differentiation / mesenchymal cells / progenitor cells / 分化誘導 / 間葉系細胞 / cDNA microarray / Hepatocellular carcinoma / 再発 / マイクロアレイ / ILK / Matrix metalloproteinase / DAF / KIR / 体外肝灌流 / Heat shock protein / 障害肝 / 拡大肝切除 / 小胞体ストレス / アポトーシス / 肝幹細胞 / ES細胞 / 温熱療法 / 虚血耐性 / 虚血再潅流障害 / undifferentiated state / hepatic stem / 未分化維持 / 肝幹・前駆細胞 / islet β cells / hepatocytes / ES cells / 膵β細胞 / 肝細胞 / Cool-tip electrode / saline enhance / RF ablation / 肝腫瘍 / ラジオ波治療 / 腫瘍焼灼術 / Recurrence / β-atenin / 定量的RT-PCR / β-カテニン / apoptosis / endoplasmic reticulum stress / hepatic ischemia reperfusion / 肝虚血再灌流 / casapase-12 / 肝虚血再潅流 / subcloning / specific surface marker genes / human hepatic stem / サブクローニング / 肝幹細胞特異的表面抗原 / ヒト肝幹細胞 / Lymph node metastasis / Rucurrence / Gastric cancer / 肝癌細胞 / リンパ節転移 / TapMan PCR / 胃癌 / Integrin / Liver cirrhosis / Thioacetamide / Extracellular matrix / Hepatocyte proliferation / 肝細胞増殖開始機構 / 肝細胞増殖因子(HGF) / BrdU labeling index / adenovirus vector / Matrix metalloprotease(MMP) / Matrix metalloprotease / インテグリン / 肝硬変 / チオアセトアミド(TAA) / 細胞外マトリックス(ECM) / 肝細胞増殖 / PREV / transgenic pig / baboon / xenogeneic liver / extracorperal live perfusion / liver assist device / レトロウイルス / ブタ / IgY / レトロウィルス / 体外異種肝灌流 / ブタ内因性レトロウイルス / 遺伝子導入ブタ / ヒヒ / 異種肝臓 / 人工肝臓 / Damaged liver / Hyperthermia / Preconditioning / Ischemic tolerance / Ischemia-reperfusion Injury / Molecular chaperone / Extended liver Surgery / プレコンディショニング / 虚血再灌流障害 / 熱ショック蛋白 / 分子シャペロン / gene transfer / near-infrared tissue spectroscopy / hepatic energy metabolism / liver surgery / クレアチンキナーゼ / エンドトキシン肝障害 / 術後肝不全 / ミオグロビン / アデノウイルスベクター / ICAM-1 / 肝組織内SO2 / 遺伝子導入 / 近赤外光スペクトロスコピー / 肝エネルギー代謝 / 肝臓外科 / NK cell / MHC-class 1 / donor-specific gene / micro-chmerism / immunotolerance / NK細胞 / MHC-class I / ドナー特異的遺伝子 / マイクロキメリズム / 免疫寛容誘導 / Soluble Complement Receptor Type 1 (sCR1) / Prostaglandin E1 / Humoral Injury / Liver Assist Device / Liver Xenoperfusion / Liver Fallure / 可溶性補体受容体 / 常温持続灌流 / 異種血液灌流 / 1型可溶性補体受容体 / 超急性拒絶反応 / 人工肝補助装置 / プロスタグランジンE1 / 可溶性1型補体受容体 / 液性傷害 / 異種移植 / 肝補助装置 / 異種肝灌流 / 肝不全 / Stress response / Fatty liver / Damaged liver protection / Ischemic tolerance of the liver / Artificial vessels / Extended hepatectomy / Extra-corporeal hepatectomy / 四塩化炭素 / 対外抗癌療法 / フリーラジカル / 対外肝切除 / ストレス応答 / 脂肪肝 / 障害肝保護 / 肝温阻血耐性 / 熱ショックタンパク / 人工血管 / 体外肝切除 / oxygen satulation / hepaticsinusoid / micro circulation / Near infra-red spectroscopy / REGECTION / Liver TRASPLANTATION / 脳死肝移植 / 生体部分肝移植 / 近赤外光分析 / primary-nonfunction / 拒絶反応 / heterogeneity / 組織酸素化 / 肝類洞 / 近赤外線分析 / 肝移植 / gp38 / 表面抗原 / JNK / GADD153 / CHOP / ストレス / 癌 / 細胞移植治療 / haplo-insufficiency / methylation / mutation / tumor suppressor gene / Apoptosis / β-catenin / 蛋白精製 / cis-trans peptidyl-prolyl isomerase / calcineurin / ピロリン酸 / inorganic pyrophosphatase / FK506 / FKBP12 / 耐性獲得 / 肝切除 / 肝癌 / サイパ-サーミア / 熱、ショックタンパク Less

膵癌における癌幹細胞の特性解析ならびに膵癌幹細胞の起源に関する検討Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Establishment of a new method of inducing differentiation from human embryonic stem cells to hepatocytes in vitro and investigation of the clinical utility for cell transplantation.Principal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Modification of endoplasmic reticulum stress expands surgical indication in hepatocellular carcinom a
- Principal Investigator
  
  HATANO Etsuro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Isolation and characterization of murine hepatic stem cells (HPCs) based on a new surface antigen.
- Principal Investigator
  
  YASUCHIKA Kentaro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
肝幹細胞単離および肝癌細胞との特性比較解析による肝癌幹細胞同定Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Establishment of hepatocyte differentiation from human embryonic stem cells in the realizaion of cell transplantation therapy for liver disease.Principal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Establishment of differentiation protocols for mouse embryonic stem cells into hepatocytes and insulin producing islet β cells.
- Principal Investigator
  
  YASUCHIKA Kentaro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Establishment of the maintenance for hepatic stem/progenitor cells with undifferentiated state using mesenchymal cells
- Principal Investigator
  
  FUKUCHI Yoshie
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
マウスES細胞由来肝細胞の新規分化誘導法の確立および細胞移植における有用性の検討
- Principal Investigator
  
  FUJII Hideaki
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
胆管前駆細胞の特性解析と胆管形成を伴う高次機能肝組織再構築に関する研究Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
SIAH1の肝発癌における関与の解明と肝癌遺伝子治療の可能性に関する研究
- Principal Investigator
  
  HASEGAWA Suguru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Establishment of new therapeutic modality for liver failure using hepatic stem cells (Remodeling of the injured liver of toxin receptor-mediated cell knockout (TRECK) mice)Principal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
The research to establish the recurrence predicting system for hepatocellular carcinoma patients by use of genome-wide microarray database and to identify therapeutic molecular targets
- Principal Investigator
  
  SATOH Seiji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
The development of new radiofrequency device and its clinical application
- Principal Investigator
  
  SHIBATA Toshiya
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Contribution to the extended hepatectomy by the modulation of endoplasmic reticulum stress-induced cell death
- Principal Investigator
  
  HATANO Etsuro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Isolation and characterization of human hepatic stem/progenitor cells and reconstruction of liver tissuePrincipal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Establishment of a isolation and maturation system for human adult hepatic stem cells
- Principal Investigator
  
  NAKATSUJI Norio, 廣瀬哲朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
抗原堤示の場としての二次的リンパ組織の意義の解明と免疫寛容誘導への基礎的検討Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
The research to establish the orader-made therapy system for hepatocellular carcinoma patients by use of genome-wide microarray database
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
The investigation of the mechanism of xenogeneic immunoreaction and its control…Examination from the organ specificity of the liver in xenotrnaplantation…Principal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
肝再生機序及び肝硬変における未知35kDa蛋白質の重要性-その構造解析と作用の解明-
- Principal Investigator
  
  MORIMOTO Taisuke
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Development of bioartificial liver using transgenic pigPrincipal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Infectious and immunological evaluation of xenogeneic extracorporeal liver perfusion and preclinical study
- Principal Investigator
  
  YAMAOKA Yoshiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Acceleration of liver regeneration by gene transfer with matrix metalloproteinase (MMP)-1
- Principal Investigator
  
  IIMURO Yuji, 森本泰介
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
抗FKBP12自己抗体の肝移植後の拒絶反応および自己免疫疾患における臨床的意義Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Moduration of the molecular chaperone activity to increase the safety of extended liver surgery in the damaged liver patients -- challenge by the induction of stress response and heat shock gene transfection --
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Regulation of xenograft rejection for the clinical utilization of porcine livers - Inhibiton of complement cascade and Kupffer cell activationPrincipal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Development of bioartificial liver using human hepatocytesPrincipal Investigator
- Principal Investigator
  
  IKAI Iwao
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
肝移植における免疫制御機構に関する実験的研究と免疫抑制療法への応用Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
ヒト肝ハイパーサーミアによる熱ショック蛋白誘導に関する研究-虚血再灌流障害に対する耐性獲得の試み
- Principal Investigator
  
  尾崎信弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Comparative study of immunological tolerance in the liver transplantation from cadaver and living donor
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Relationship among hepatic microcirculation, metabolism and bioactive substances : Elucidation of postoperative heptaci failure
- Principal Investigator
  
  YAMAMOTO Masayuki
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
肝移植における免疫制御機構に関する研究-新たな血清可溶型蛋白S-FKBP1.2の同定と意性拒絶反応との関連について-Principal Investigator
- Principal Investigator
  
  猪飼伊和夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Non-touch isolation hepatectomy and extra-corporeal anticancer therapy for liver tumors-Feedback of surgical technique in living-related partial liver transplantation to liver surgery-
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Development of the artificial liver assist device with normothermic xenoperfusion system of the whole liver
- Principal Investigator
  
  YAMAOKA Yosio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
Comperative study in the viability of the liver graft harvested from cadaver and living donor, evaluated by assessment of tissue oxygenation in sinusoid and oxidation of hepatocyte
- Principal Investigator
  
  YAMAOKA Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY

All 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers2011
- Author(s)
  小西小百合、安近健太郎、石井隆道、福光剣、加茂直子、藤田直哉、猪飼伊和夫、上本伸二
- Journal Title
  
  In Vitro Cell.Dev.Biol.Animal Vol.47
  
  Pages: 45-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591610
[Journal Article] In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers2010
- Author(s)
  石井隆道、安近健太郎、福光剣、猪飼伊和夫以下7名
- Journal Title
  
  Cell Tissue Research Vol.339、No.3
  
  Pages: 505-512
- NAID
  120002511339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591610
[Journal Article] In vitro hepatic aturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers2010
- Author(s)
  石井隆道、安近健太郎、福光剣、猪飼伊和夫
- Journal Title
  
  Cell Tissue Research Vo1.339, No.3
  
  Pages: 505-512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390356
[Journal Article] Establishment of a cell line derived from a mouse fetal liver that has the characteristic to promote the hepatic maturation of mouse embryonic stem cells by a coculture method, Tissue Engineering.2009
- Author(s)
  福光剣、石井隆道、安近健太郎、猪飼伊和夫
- Journal Title
  
  Part A Vo1.15、No.12
  
  Pages: 3847-3856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390356
[Journal Article] A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.2009
- Author(s)
  Narita M., Hatano, E., Ikai, I., et al.
- Journal Title
  
  Ann Surg 249
  
  Pages: 1397-1401
- NAID
  120001479079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591609
[Journal Article] Inhibition of c-Jun NH_2-Terminal Kinase Switches Smad3 Signaling from Oncogenesis to Tumor-suppression in Rat Hepatocellular Carcinoma2009
- Author(s)
  Nagata, H., Hatano, E., Tada, M., Murata, M., Kitamura, K., Asechi, H., Narita, M., Yanagida, A., Tamaki, N., Yagi, S., Ikai, I., Matsuzaki, K., Uemoto, S.
- Journal Title
  
  Hepatology 49(6)
  
  Pages: 1944-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591609
[Journal Article] Effects of extracellular matrixes and growth factors on the hepatic differentiation of human embryonic stem cells, American Journal of Physiology.2008
- Author(s)
  石井隆道、福光剣、安近健太郎、猪飼伊和夫
- Journal Title
  
  Gastrointestine and Liver physiology Vo1.295、No.2
  
  Pages: 313-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390356
[Journal Article] CHOP-deficiency attenuates cholestasis-induced liver fibrosis by redcution of hepatocyte injury.2008
- Author(s)
  Tamaki, N., Hatano, E., Taura, K., Tada, M., Kodama Y., Nitta, T., Iwaisako, K., Seo, S., Nakajima, A., Ikai, I., Uemoto, S.
- Journal Title
  
  Am J Physiol 294(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591609
[Journal Article] Effects of extracellular matrixes and growth factors on the hepatic differentiation of human embryonic stem cells.2008
- Author(s)
  Ishii T, Ikai I, et. al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 298(2)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] Improvement of the survival rate by fetal liver cell transplantation in a mice lethal liver failure model.2007
- Author(s)
  Machimoto T, Ikai I, et. al.
- Journal Title
  
  Transplantation 84(10)
  
  Pages: 1233-1239
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] Two populations of Thy 1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells2007
- Author(s)
  Kamo N, Ikai I, et. al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292(2)
  
  Pages: 526-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] Transplantation of embryonic stem cell-derived endodermal cells into mice with induced lethal liver damage.2007
- Author(s)
  Ishii T, Yasuchika K, Machimoto T, Kamo N, Komori J, Konishi S, Suemori H, Nakatsuji N, Saito M, Kohno K, Uemoto S, Ikai I
- Journal Title
  
  Stem Cells 25(12)
  
  Pages: 3252-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591410
[Journal Article] Transplantation of embryonic stem cell-derived endodermal cells into mice with life-threatning liver2007
- Author(s)
  Ishii T, Ikai I, et. al.
- Journal Title
  
  Stem Cells 25(12)
  
  Pages: 3252-3260
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] Improvement of the survival rate by fetal liver cell transplantatioi in a mice lethal liver failure model.2007
- Author(s)
  Machimoto T, Yasuchika K, Komori J, Ishii T, Kamo N, Shimoda M, Konishi S, Saito M, Kohno K, Uemoto S, Ikai I
- Journal Title
  
  Transplantation 84(10)
  
  Pages: 1233-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591410
[Journal Article] Two populations of Thyl-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells2007
- Author(s)
  Kamo N, Ikai I, et. al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292(2)
  
  Pages: 526-554
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] A homeobox protein, proxl, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma.2006
- Author(s)
  Shimoda M, Ikai I, et. al.
- Journal Title
  
  Clin Cancer Res 12(20Pt1)
  
  Pages: 6005-6011
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] A homeobox protein, proxl, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma.2006
- Author(s)
  Shimoda M, Ikai I, et. al.
- Journal Title
  
  Clin Cancer Res 12(20 Pt 1)
  
  Pages: 6005-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Journal Article] Hepatic organoid formation in collagen sponge of cells isolated from human liver tissues.2005
- Author(s)
  Sugimoto S, Ikai I, et al.
- Journal Title
  
  Tissue Eng. 11(3-4)
  
  Pages: 626-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Journal Article] AsialoGM1 positive CD8+ T cells induce skin allograft ejection in the absence of the secondary lymphoid organs.2005
- Author(s)
  Yamanokuchi S, Ikai I, et al.
- Journal Title
  
  J Surg Res 129(1)
  
  Pages: 57-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Journal Article] Relocation of Truncated Bid Plays an Important Role in Suppression of Tumor Necrosis Factor a-Induced Apoptosis in Hepatocytes Isolated from Transgenic Mouse.2005
- Author(s)
  Shiotani T, Ikai I, et al.
- Journal Title
  
  J Surg Res 127(2)
  
  Pages: 157-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Journal Article] In vitro differentiation and maturation of mouse embryonic stem cells into hepatocytes.2005
- Author(s)
  Ishii T, Ikai I, et al.
- Journal Title
  
  Experimental Cell Research 309(16)
  
  Pages: 68-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Journal Article] Thyl-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver.2004
- Author(s)
  Hoppo T, Ikai I, et al.
- Journal Title
  
  Hepatology 39(5)
  
  Pages: 1362-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Journal Article] Results of hepatic resection for hepatocellular carcinoma invading major portal and/or hepatic veins.2003
- Author(s)
  I.Ikai
- Journal Title
  
  Surg Oncol Clin N Am 12巻・1号
  
  Pages: 65-75
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591401
[Journal Article] Results of hepatic resection for hepatocellular carcinoma invading major portal and/or hepatic veins.2003
- Author(s)
  Ikai I
- Journal Title
  
  Surg Oncol Clin N Am 12(1)
  
  Pages: 65-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591401
[Journal Article] Two populations of Thyl positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells
- Author(s)
  Kamo N, Ikai I et al.
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390361
[Presentation] Comparative study of transplantation of cells at various differentitation stages into mice with induced lethal liver damage2010
- Author(s)
  上村良、石井隆道、安近健太郎、猪飼伊和夫
- Organizer
  第45回欧州肝臓学会議(EASL)
- Place of Presentation
  ウィーン、オーストリア
- Data Source
  KAKENHI-PROJECT-20591610
[Presentation] Variation in hepatic differentiation propensity among human induced pluripotent stem cell (iPSC) lines2010
- Author(s)
  梶原正俊、石井隆道、猪飼伊和夫、上本伸二、山中伸弥
- Organizer
  The 8th International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-20591610
[Presentation] Variation in hepatic differentiation propensity among human induced pluripotent stem cell (iPSC) lines2010
- Author(s)
  梶原正俊、石井隆道、猪飼伊和夫、上本伸二、山中伸弥
- Organizer
  The 8th International Society for Stem CellResearch (ISSCR)
- Place of Presentation
  San Francisco, U.S.A
- Data Source
  KAKENHI-PROJECT-20390356
[Presentation] Comparative study of transplantation of cells at various differentitation stages into mice withinduced lethal liver damage2010
- Author(s)
  上村良、石井隆道、安近健太郎、猪飼伊和夫
- Organizer
  第45回欧州肝臓学会議(EASL)
- Place of Presentation
  ウィーン、オーストリア
- Data Source
  KAKENHI-PROJECT-20390356
[Presentation] JNKの肝発癌過程における分子標的意義- JNK阻害剤による肝細胞癌治療の可能性-2009
- Author(s)
  長田博光, 波多野悦朗, 阿世知弘行, 成田匡大, 柳田敦子, 玉置信行, 猪飼伊和夫, 松崎恒一, 上本伸二
- Organizer
  第109回日本外科学会
- Place of Presentation
  福岡
- Year and Date
  2009-04-04
- Data Source
  KAKENHI-PROJECT-20591609
[Presentation] ラット肝癌モデルにおけるJNK阻害剤による抗腫瘍効果2008
- Author(s)
  長田博光、波多野悦朗、多田正晴、阿世知弘行、成田匡大、柳田敦子、玉置信行、猪飼伊和夫、松崎恒一、上本伸二
- Organizer
  第63回日本消化器外科学会定期学術総会
- Place of Presentation
  札幌
- Year and Date
  2008-07-17
- Data Source
  KAKENHI-PROJECT-20591609
[Presentation] ヒトES細胞を用いた初期肝細胞への分化誘導法の検討2008
- Author(s)
  福光剣, 石井隆道, 安近健太郎, 末盛博文, 中辻憲夫, 猪飼伊和夫, 上本伸二
- Organizer
  第7回日本再生医療学会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-13
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Effects of extracellular matrixes and growth factors on the hepatic differentiation of human embryonic stem cells.2008
- Author(s)
  Fukumitsu K, Ikai I, et. al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Isolation of hepatic stem cells using a novel surface antigen2008
- Author(s)
  KonishiS, Ikai I, et. al.
- Organizer
  108^<th> annual meeting of Japan Surgical Society
- Place of Presentation
  Nagasaki
- Year and Date
  2008-03-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Differentiation of human embryonic stem cells to hepatic progenitor cells.2008
- Author(s)
  Fukumitsu K, Ikai I, et. al.
- Organizer
  7^<th> annual meeting of Japanese Society for Regenerative Medicine
- Place of Presentation
  Nagoya
- Year and Date
  2008-03-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Isolation of hepatic stem cells using a novel surface antigen : gp382008
- Author(s)
  Konishi S, Ikai I, et. al.
- Organizer
  43^<rd> annual meeting of European Association for the study of the liver (EASL)
- Place of Presentation
  Milan
- Year and Date
  2008-04-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Cell transplantation of embryonic stem cell-derived endodermal cells into life-threatening liver injury model mice2007
- Author(s)
  Ishii T, Ikai I, et. al.
- Organizer
  17^<th> annual meeting of Asian Pacific Association for the Study of the Liver (APASL)
- Place of Presentation
  Kyoto
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Improvement of the survival rate after the cell transplantation of endodermal cells derived from mouse embryonic stem cells into lethal liver damaged model mice.2007
- Author(s)
  Ishii T, Ikai I, et. al.
- Organizer
  6^<th> annual meeting of Japanese Society for Regerative Medicine
- Place of Presentation
  Yokohama
- Year and Date
  2007-03-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Transplantation of embryonic stem cellderived endodermal cells Into life-threatening live injury model mice2007
- Author(s)
  Ishii T, Ikai I, et. al.
- Organizer
  5^<th> annual meeting of International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  Cairns
- Year and Date
  2007-06-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Improvement of the survival of lethal liver damaged model mice after the cell transplantation of endodermal cells derived from mouse embryonic stem cells.2007
- Author(s)
  IshiiT, Ikai I, et. al.
- Organizer
  28^<th> annual meeting of Japanese Society of Imflammation and Regeneration
- Place of Presentation
  Tokyo
- Year and Date
  2007-08-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] Cell transplantation of endodermal cells derived from mouse embryonic stem cells.2007
- Author(s)
  Ishii T, Ikai I et. al.
- Organizer
  107^<th> annual meeting of Japan Surgical Society
- Place of Presentation
  Osaka
- Year and Date
  2007-04-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365
[Presentation] 胆管癌における癌幹細胞としてのAFP産生細胞2007
- Author(s)
  石井隆道, 安近健太郎, 福光剣, 末盛博文, 中辻憲夫, 猪飼伊和夫, 上本伸二
- Organizer
  第7回日本再生医療学会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-14
- Data Source
  KAKENHI-PROJECT-19659340
[Presentation] Isolation of hepatic stem cells using a novel surface antigen2007
- Author(s)
  Konishi S, Ikai I, et. al.
- Organizer
  5^<th> annual meeting of International Society for Stem Cell Research
- Place of Presentation
  Cairns
- Year and Date
  2007-06-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390365

1. YAMAOKA Yoshio (90089102)

# of Collaborated Projects: 17 results

# of Collaborated Products: 0 results
2. YASUCHIKA Kentaro (00378895)

# of Collaborated Projects: 10 results

# of Collaborated Products: 11 results
3. YAMAMOTO Yuzo (70281730)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. OZAKI Nobuhiro (50211818)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
5. HATANO Etsuro (80359801)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
6. UEMOTO Shinji (40252449)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
7. SATOH Seiji (00303834)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. SAKAI Yoshiharu (60273455)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. TERAJIMA Hiroaki (40314215)

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10. SHIMAHARA Yasuyuki (30196498)

# of Collaborated Projects: 3 results

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11. MORIMOTO Taisuke (60135910)

# of Collaborated Projects: 3 results

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12. IIMURO Yuji (30252018)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. FUJII Hideaki (50372587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. ISHII Takamichi (70456789)

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# of Collaborated Products: 9 results
15. INAMOTO Takashi (10135577)

# of Collaborated Projects: 3 results

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16. NAKATSUJI Norio (80237312)

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# of Collaborated Products: 1 results
17. 山内清明 (00291427)

# of Collaborated Projects: 3 results

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18. IWATA Hiroo (30160120)

# of Collaborated Projects: 2 results

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19. HASEGAWA Suguru (10362500)

# of Collaborated Projects: 2 results

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20. KAMO Naoko (50452355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
21. INOMATA Yukihiro (50193628)

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22. TANAKA Akira (00240820)

# of Collaborated Projects: 2 results

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23. TANAKA Koichi (20115877)

# of Collaborated Projects: 2 results

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24. YAMAMOTO Masayuki (30158307)

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25. HIROSE Tetsuro (00314279)

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26. 待本貴文 (70437234)

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27. NITTA Takashi (40456877)

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28. SAWASAKI Yoshio (90092410)

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29. YAMAMOTO Naritaka (30253298)

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30. MITAKA Toshihiro (50231618)

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31. UESUGI Takehiko (20362494)

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32. KOHNO Kenji (50142005)

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33. KISHIMOTO Michimasa (00144436)

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34. FUKUSHIMA Masanori (80107820)

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38. 小西小百合 (10512345)

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54. PLATT Jeffre

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Ikai Iwao 猪飼 伊和夫

IKAI Iwao 猪飼 伊和夫

Research Projects

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Co-Researchers

膵癌における癌幹細胞の特性解析ならびに膵癌幹細胞の起源に関する検討Principal Investigator

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Establishment of a new method of inducing differentiation from human embryonic stem cells to hepatocytes in vitro and investigation of the clinical utility for cell transplantation.Principal Investigator

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肝幹細胞単離および肝癌細胞との特性比較解析による肝癌幹細胞同定Principal Investigator

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Establishment of hepatocyte differentiation from human embryonic stem cells in the realizaion of cell transplantation therapy for liver disease.Principal Investigator

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胆管前駆細胞の特性解析と胆管形成を伴う高次機能肝組織再構築に関する研究Principal Investigator

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Establishment of new therapeutic modality for liver failure using hepatic stem cells (Remodeling of the injured liver of toxin receptor-mediated cell knockout (TRECK) mice)Principal Investigator

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Ikai Iwao 猪飼伊和夫

IKAI Iwao 猪飼伊和夫