AOKI Kazunori 青木一教

Researcher Number	60270675
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 分野長
Affiliation (based on the past Project Information) *help	2016 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 分野長 2019: 国立研究開発法人国立がん研究センター, 研究所, 副所長・分野長 2017: 国立研究開発法人国立がん研究センター, 分子細胞治療研究分野, 分野長 2011 – 2013: 独立行政法人国立がん研究センター, 研究所, 分野長
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Experimental pathology / Human genetics Except Principal Investigator Basic Section 49020:Human pathology-related / Basic Section 56010:Neurosurgery-related / Basic Section 52030:Psychiatry-related / Studies on the Super-Aging Society / Neurosurgery
Keywords	Principal Investigator がん関連間質線維芽細胞 / 制御性T細胞 / がん関連線維芽細胞 / 腫瘍微小環境 / 膵がん / 免疫学 / 間質線維芽細胞 / 肺がん / シングルセル解析 / サイトカイン … More / 骨髄由来抑制細胞 / 化学免疫療法 / 腫瘍免疫 / 免疫抑制性環境 / プロモーター / 遺伝子導入 / 低酸素 / 造血幹細胞移植 / 制御性Ｔ細胞 / 免疫抑制環境 … More Except Principal Investigator 悪性グリオーマ / アデノウイルスベクター / 中性子捕捉療法 / ドラッグデリバリーシステム / ホウ素修飾 / 術後せん妄 / 胆管がん / 膵がん / 免疫環境 / 血管 / がん微小環境 / ドパミン / 制御性T細胞 / Th17細胞 / 免疫ランドスケープ / 二重盲検化比較試験付随研究 / 付随研究 / 高侵襲手術 / 免疫制御 / 多施設共同二重盲検プラセボ対照ランダム化比較試験 / AI病理学 / デジタル病理学 / 病理組織 / 治療効果予測 / 形態学的バイオマーカー / 外科的がん切除 / 発症予測バイオマーカー / データベース作成 / 末梢血ドパミン / 網羅的探索 / カテコールアミン / 炎症性サイトカイン / 過活動型せん妄 / 低活動型せん妄 / がん / 前向きコホート / バイオマーカー / 発症機序 / 電子顕微鏡 / ガンマ線 / 中性子 / アデノウイルスライブラリー / ホウ素化合物 Less

Vascular roles in tumor immune microenvironment of pancreatic and biliary cancers
- Principal Investigator
  
  平岡伸介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
Development of neutron capture therapy using adenovirus genome-terminal protein complex for drug delivery
- Principal Investigator
  
  濱聖司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hiroshima University
術後せん妄発症を制御する免疫ランドスケープの解明
- Principal Investigator
  
  貞廣良一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  National Cancer Center Japan
Modulation of Immune suppressive tumor microenvironment based on inhibition of interaction between CAF and Treg in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Aoki Kazunori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Cancer Center Japan
Development study on pathological predictive biomarkers for cancer treatment
- Principal Investigator
  
  元井紀子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
Clinical application of boron-conjugated adenovirus vector for neutron capture therapy
- Principal Investigator
  
  Hama Seiji
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hiroshima University
Exploration of biomarkers predicting onset of postoperative delirium following surgical cancer resection
- Principal Investigator
  
  Sadahiro Ryoichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  National Cancer Center Japan
Development of chemo-immunotherapy based on the characterization of tumor-infiltrating myeloid-derived suppressor cellsPrincipal Investigator
- Principal Investigator
  
  Aoki Kazunori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Japan
Development of targeting adenovirus vector as boron carrier for boron neutron capture therapy
- Principal Investigator
  
  HAMA Seiji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hiroshima University
Development of immunosuppressive microenvironment-breaking immune therapy with autologous hematopoietic stem cell transplantationPrincipal Investigator
- Principal Investigator
  
  AOKI Kazunori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  National Center of Neurology and Psychiatry

All 2024 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] Cellular and Genetic Practices for Translational Medicine2011
- Author(s)
  Narumi K, Aoki K.
- Total Pages
  260
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-23590384
[Book] Combination of immune gene therapy with allogeneic hematopoietic stem cell transplantation against solid cancers. In : Cellular and Genetic Practices for Translational Medicine ed. by J-Y. Kwak and J-Y2011
- Author(s)
  Narumi K, Aoki K
- Publisher
  Han. Research Signpost, Kerala, India
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer2024
- Author(s)
  Ohashi Kana、Nishito Yukari、Fukuda Hironori、Sadahiro Ryoichi、Yoshida Yukihiro、Watanabe Shun-ichi、Motoi Noriko、Sonobe Yukiko、Mizuno Hideaki、Tsunoda Hiroyuki、Tatsumi Koichiro、Suzuki Takuji、Ochiai Atsushi、Aoki Kazunori
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41598-023-50378-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06900
[Journal Article] An algorithm-based technique for counting mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections2024
- Author(s)
  Sakashita Mai、Motoi Noriko、Yamamoto Gaku、Gambe Emi、Suzuki Masanori、Yoshida Yukihiro、Watanabe Shun-ichi、Takazawa Yutaka、Aoki Kazunori、Ochiai Atsushi、Sakashita Shingo
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 150 Issue: 4
- DOI
  10.1007/s00432-024-05653-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06899, KAKENHI-PROJECT-21K06900
[Journal Article] Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments2024
- Author(s)
  Fukuda Hironori、Arai Kosuke、Mizuno Hideaki、Nishito Yukari、Motoi Noriko、Arai Yasuhito、他、Aoki Kazunori
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 1763-1777
- DOI
  10.1111/cas.16154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06900
[Journal Article] Comprehensive assessment of PD-L1 expression, tumor mutational burden and oncogenic driver alterations in non-small cell lung cancer patients treated with immune checkpoint inhibitors2021
- Author(s)
  Yoh Kiyotaka、Matsumoto Shingo、Furuya Naoki、Nishino Kazumi、Miyamoto Shingo、Oizumi Satoshi、Okamoto Norio、Itani Hidetoshi、Kuyama Shoichi、Nakamura Atsushi、Nishi Koichi、Fukuda Ikue、Tsuta Koji、Hayashi Yuichiro、Motoi Noriko、Ishii Genichiro、Goto Koichi
- Journal Title
  
  Lung Cancer
  
  Volume: 159 Pages: 128-134
- DOI
  10.1016/j.lungcan.2021.07.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07036, KAKENHI-PROJECT-21K06900
[Journal Article] Pre-immunization of donor lymphocytes with GITR agonistic antibody enhances antitumor immunity in autologous hematopoietic stem cell transplantation2019
- Author(s)
  Henmi Marina、Shibasaki Chihiro、Mizoguchi Yukihiro、Hirata Aya、Sawai Eri、Narumi Kenta、Aoki Kazunori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 1 Pages: 96-101
- DOI
  10.1016/j.bbrc.2018.12.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] Local Administration of GITR Agonistic Antibody Induces a Stronger Antitumor Immunity than Systemic Delivery2019
- Author(s)
  Narumi Kenta、Miyakawa Reina、Shibasaki Chihiro、Henmi Marina、Mizoguchi Yukihiro、Ueda Ryosuke、Hashimoto Hisayoshi、Hiraoka Nobuyoshi、Yoshida Teruhiko、Aoki Kazunori
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41598-019-41724-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression2018
- Author(s)
  Hirata Aya、Hashimoto Hisayoshi、Shibasaki Chihiro、Narumi Kenta、Aoki Kazunori
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: - Issue: 9-10 Pages: 334-343
- DOI
  10.1038/s41417-018-0059-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] がん免疫療法開発のガイダンス20162018
- Author(s)
  青木一教、中釡斉
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 69 Pages: 207-211
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] Recent advances in genetic modification of adenovirus vectors for cancer treatment2017
- Author(s)
  Y. Yamamoto, M. Nagasato, T. Yoshida, K. Aoki
- Journal Title
  
  Cancer Sci
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy2017
- Author(s)
  Shoji H, Heike Y, Tada K, Kitano S, Nishimura T, Shimada Y, Nagashima K, Aoki K, Hiraoka N, Honma Y, Iwasa S, Takashima A, Kato K, Boku N, Honda K, Yamada T, Hamaguchi T.
- Journal Title
  
  OncoTarget
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] がん免疫微小環境のシングルセル解析で何がわかってきたか2017
- Author(s)
  青木一教
- Journal Title
  
  実験医学
  
  Volume: ３５ Pages: 552-556
- Data Source
  KAKENHI-PROJECT-16K08752
[Journal Article] Pretreatment Immune Status Correlates with Progression-Free Survival in Chemotherapy-Treated Metastatic Colorectal Cancer Patients.2016
- Author(s)
  Tada K, Kitano S, Shoji H, Nishimura T, Shimada Y, Nagashima K, Aoki K, Hiraoka N, Honma Y, Iwasa S, Okita N, Takashima A, Kato K, Yamada Y, Katayama N, Boku N, Heike Y, Hamaguchi T.
- Journal Title
  
  Cancer immunology research
  
  Volume: 4(7) Issue: 7 Pages: 592-599
- DOI
  10.1158/2326-6066.cir-15-0298
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460981, KAKENHI-PROJECT-16K08752, KAKENHI-PROJECT-16K19381
[Journal Article] Suppression of Tregs by anti-GITR antibody enhances the antitumor immunity of IFN-alpha gene therapy for pancreatic cancer.2014
- Author(s)
  K. Aida, R. Miyakawa, K. Suzuki, K. Narumi, T. Udagawa, Y. Yamamoto, T. Chikaraishi, T. Yoshida, K. Aoki.
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 2 Pages: 636-645
- DOI
  10.1111/cas.12332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590384, KAKENHI-PROJECT-25830108
[Journal Article] Pre-immunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation2013
- Author(s)
  Suzuki K, Aida K, Miyakawa R, Narumi K, Udagawa T, Goto N, Yoshida T, Ohshima Y, Aoki K
- Journal Title
  
  Cancer Med
  
  Volume: 2 Pages: 636-645
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] VEGF-D-mediated blockade of regulatory T cells within tumors is induced by hematopoietic stem cell transplantation2013
- Author(s)
  Udagawa T, Narumi K, Suzuki K, Aida K, Miyakawa R, Ikarashi Y, Makimoto A, Chikaraishi T, Yoshida T, Aoki K
- Journal Title
  
  J Immunol
  
  Volume: 191 Pages: 3440-3452
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] Pre-immunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation.2013
- Author(s)
  K. Suzuki, K. Aida, R. Miyakawa, K. Narumi, T. Udagawa, N. Goto, T. Yoshida, Y. Ohshima, K. Aoki.
- Journal Title
  
  Cancer Medicine
  
  Volume: 2 Issue: 5 Pages: 636-645
- DOI
  10.1002/cam4.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590384, KAKENHI-PROJECT-25830108
[Journal Article] VEGF-D-mediated blockade of regulatory T cells within tumors is induced by hematopoietic stem cell transplantation.2013
- Author(s)
  T. Udagawa, K. Narumi, K.Suzuki, K. Aida, R. Miyakawa, Y. Ikarashi, A. Makimoto, T. Chikaraishi, T. Yoshida and K. Aoki.
- Journal Title
  
  Journal of Immunology
  
  Volume: 191 Issue: 6 Pages: 3440-3452
- DOI
  10.4049/jimmunol.1201454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590384, KAKENHI-PROJECT-25830108
[Journal Article] Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of intratumoral type I interferon gene transfer for sarcoma2012
- Author(s)
  Udagawa T, Narumi K, Goto N, Aida K, Suzuki K, Makimoto A, Ochiya T, Yoshida T, Chikaraishi T, Aoki K
- Journal Title
  
  Hum. Gene Ther
  
  Volume: 23 Pages: 173-186
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] Real-time zn vzvo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents, Immunology Letters2012
- Author(s)
  Takahiro Yamazaki, Yoshinori Ikarashi et al.
- Journal Title
  
  Immunology Letters
  
  Volume: 144巻 Issue: 1-2 Pages: 33-40
- DOI
  10.1016/j.imlet.2012.03.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590372, KAKENHI-PROJECT-23590384
[Journal Article] Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of intratumoral type I interferon gene transfer for sarcoma2012
- Author(s)
  Udagawa T, Narumi K, Goto N, Aida K, Suzuki K, Makimoto A, Ochiya T, Yoshida T, Chikaraishi T, Aoki K
- Journal Title
  
  Human Gene Therapy
  
  Volume: 23 Issue: 2 Pages: 173-186
- DOI
  10.1089/hum.2011.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] In vivo interferon-αgene transfer enhances antitumor immunity afterautologous hematopoietic stem cell transplantation2012
- Author(s)
  Narumi K, Udagawa T, Kobayashi A, Hara H, Kondoh A, Goto N, Ikarashi Y, Ohnami S, Takeshita F, Ochiya T, Okada T, Yamagishi M, Yoshida T, Aoki K
- Journal Title
  
  Gene Ther
  
  Volume: 19 Pages: 34-48
- Data Source
  KAKENHI-PROJECT-23590384
[Journal Article] In vivo delivery of interferon-α gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts2011
- Author(s)
  Narumi, K., Udagawa, T., Kondoh, A., Kobayashi, A., Hara, H., Ikarashi, Y., Ohnami, S., Takeshita, F., Ochiya, T., Okada, T., Yamagishi, M., Yoshida, T., Aoki, K.
- Journal Title
  
  Gene Therapy
  
  Volume: 287 Issue: 1 Pages: 1397-1405
- DOI
  10.1038/gt.2011.73
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-22590372, KAKENHI-PROJECT-23590384
[Patent] 身体に対する侵襲に伴うせん妄の発症リスクの予測用バイオマーカー2021
- Inventor(s)
  上園保仁, 青木一教, 貞廣良一, 清水研, 杉本昌弘
- Industrial Property Rights Holder
  国立研究開発法人国立がん研究センター, 学校法人慶應義塾
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-008936
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K18468
[Presentation] 2.Immune cell profile in peripheral blood is associated with the onset of postoperative delirium2020
- Author(s)
  Ryoichi Sadahiro, Ken Shimizu, Teruhiko Yoshida, Yasuhito Uezono, Sei Manabe, Shigehisa Kitano, Kazunori Aoki
- Organizer
  第79回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K18468
[Presentation] 1.がん手術後のせん妄及び炎症関連せん妄症状を予測するインターロイキン6のパターン　―前向き観察研究―2020
- Author(s)
  貞廣良一、Marcelo AR Kornexl、Ffion James、清水研、和田　佐保、吉田輝彦、上園保仁、真鍋星、青木一教
- Organizer
  緩和・支持・心のケア合同学術大会2020
- Data Source
  KAKENHI-PROJECT-18K18468
[Presentation] The role of cancer-associated fibroblasts in immune suppressive microenvironment of lung cancer2019
- Author(s)
  Eri Sawai, Makiko Yamashita, Aya Hirata, Yukihiro Mizoguchi, Makoto Miyazaki, Genichiro Ishii, Kazunori Aoki
- Organizer
  11th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Imbalance of Interleukin-6 and Transforming growth factor beta1 underlying the onset of postoperative delirium.2019
- Author(s)
  Ryoichi Sadahiro, Ffion James, Ken Shimizu, Teruhiko Yoshida, Yasuhito Uezono, Sei Manabe, Kazunori Aoki
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K18468
[Presentation] Tumor immune microenvironment in pancreatic cancer2018
- Author(s)
  Kazunori Aoki
- Organizer
  Asan Cancer Institute Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] The immunological role of pancreatic cancer-associated fibroblasts to construct immunosuppressive microenvironment2018
- Author(s)
  Yuria Sawada, Makiko Yamashita, Eri Sawai, Marina Henmi, Aya Hirata, Chihiro Shibasaki, Hironori Fukuda, Yukihiro Mizoguchi, Kazunori Aoki
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Effect of Imatinib mesylate to immunosuppressive microenvironment in tumor2017
- Author(s)
  Aya Hirata, Chihiro Shibasaki, Marina Henmi, Yukihiro Mizoguchi, Kazunori Aoki.
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Interferon-alpha reduces trafficking of regulatory T cells into tumor by inhibition of CCL17 expression2017
- Author(s)
  Kazunori Aoki, Chihiro Shibasaki, Hisayoshi Hashimoto
- Organizer
  American Association of Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Effect of Imatinib mesylate to immunosuppressive microenvironment in tumor2017
- Author(s)
  Aya Hirata, Chihiro Shibasaki, Marina Henmi, Yukihiro Mizoguchi, Hajime Takizawa, Kazunori Aoki
- Organizer
  第46回日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] The priming of donor cells by GITR agonist antibody enhances the antitumor immunity of hematopoietic stem cell transplantation against solid cancer2017
- Author(s)
  Marina Henmi, Yukihiro Mizoguchi, Aya Hirata, Kazunori Aoki.
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Mechanism of Antitumor immunity induced by intratumoral injection of GITR Ab2017
- Author(s)
  Chihiro Shibasaki, Kenta Narumi, Marina Henmi, Kazunori Aoki.
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Intratumoral IFN-α expression reduces trafficking of Tregs into tumor by inhibition of CCL17 expression2016
- Author(s)
  Aoki K, Shibasaki C, Hashimoto H
- Organizer
  第45回日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県、宜野湾）〉
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Development of prostate cancer-targeted adenovirus vector with peptide-displaying Ad library2016
- Author(s)
  Nagasato M, Rin Y, Henmi M, Yamamoto Y, Aoki K
- Organizer
  第75回日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] ntratumoral IFN-α expression reduces trafficking of Tregs into tumor by inhibition of CCL17 expression in tumors2016
- Author(s)
  Aoki K, Shibasaki C, Hashimoto H, Narumi K, Ueda R
- Organizer
  第75回日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] Targeting FSTL1 is a new approach to treatment of pediatric cancers2016
- Author(s)
  Henmi M, Ogiwara Y, Toyoura M, Aoki K, Kudo C
- Organizer
  第75回日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08752
[Presentation] S100A8/S100A9-mediated NK cell activation induces antitumor immunity after syngenetic hematopoietic stem cell transplantation.2013
- Author(s)
  K. Narumi, R. Miyakawa, R. Ueda, H. Hashimoto, T. Yoshida, K. Aoki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Antitumor immunity induced by autologous hematopoietic stem cell transplantation is enhanced by a priming of the donor T lymphocytes to tumor-associated antigens2013
- Author(s)
  Narumi K, Suzuki K, Miyakawa R, Aida K, Yoshida T, Aoki K
- Organizer
  9th AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  Maui
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] A combination of IFN gene therapy and GITR ab-induced reduction of Tregs enhances antitumor immunity for pancreatic cancer.2013
- Author(s)
  K. Aoki, K. Aida, K. Narumi, R. Miyakawa, N. Goto, H. Hashimoto, R. Ueda, Y. Ikarashi, S. Ohnami, T. Yoshida.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Antitumor immunity of hematopoietic stem cell transplantation differs by a priming status of donor cells2012
- Author(s)
  K Suzuki, R Miyakawa, K Aida, N Goto, K Narumi, T Yoshida, K Aoki
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Combination therapy of hematopoietic stem cell transplantation and intratumoral interferon gene transfer to sarcoma (Symposium)2012
- Author(s)
  Aoki K, Narumi K, Udagawa T
- Organizer
  第18回日本遺伝子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] VEGF-D-mediated suppression of immune-tolerant microenvironment within tumors by hematopoietic stem cell transplantation2012
- Author(s)
  R Miyakawa1, K Suzuki, K Aida, N Goto, K Narumi, T Yoshida, K Aoki
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] VEGF-D-mediated suppression of regulatory T cells within tumors by hematopoietic stem cell transplantation2012
- Author(s)
  Narumi K, T Udagawa T, Miyakawa R, Aoki K
- Organizer
  第41回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] 固形がんに対する新たな免疫遺伝子・細胞療法の開発2012
- Author(s)
  青木一教
- Organizer
  第6回日本緩和医療薬学会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of intratumoral type I interferon gene transfer for sarcoma2012
- Author(s)
  Narumi K, Udagawa T, Aida K, Suzuki K, Makimoto A, Aoki K
- Organizer
  The American Society of Gene Therapy's 15th Annual Meeting
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Suppression of immune-tolerant microenvironment within tumors by hematopoietic stem cell transplantation2012
- Author(s)
  K Aoki, T Udagawa, K Narumi.
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Combination therapy of hematopoietic stem cell transplantation and intratumoral interferon gene transfer to sarcoma2012
- Author(s)
  K Aoki, K Narumi, T Udagawa.
- Organizer
  第18回日本遺伝子治療学会学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] VEGF-D-mediated suppression of immune-tolerant microenvironment within tumors by hematopoietic stem cell transplantation2012
- Author(s)
  Miyakawa R, Suzuki K, Aida K, Goto N, Narumi K, Yoshida T, Aoki K
- Organizer
  第71回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Suppression of immune-tolerant microenvironment within tumors by hematopoietic stem cell transplantation2012
- Author(s)
  Aoki K, Udagawa T, Narumi K
- Organizer
  第71回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Antitumor immunity of hematopoietic stem cell transplantation differs by a priming status of donor cells2012
- Author(s)
  Suzuki K, Miyakawa R, Aida K, Goto N, Narumi K, Yoshida T, Aoki K
- Organizer
  第71回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of type I interferon gene transfer for sarcoma2011
- Author(s)
  T Udagawa, K Narumi, T Ochiya, T Yoshida, K Aoki
- Organizer
  第17回日本遺伝子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] In vivo delivery of interferon-alpha gene enhances tumor immunity and suppresses immunotolerance after autologous hematopoietic stem cell transplantation.2011
- Author(s)
  Narumi　K, Udagawa T, Ikarashi Y, Ochiya T, Yoshida T, Aoki K
- Organizer
  The American Society of Gene Therapy’s 14th Annual Meeting
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Autologous hematopoietic stem cell transplantation suppresses immunotolerant environment in tumors and induces antitumor immunity2011
- Author(s)
  T Udagawa, K Narumi, Y Ikarashi, S Ohnami, T Yoshida, K Aoki
- Organizer
  第70回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Autologous hematopoietic stem cell transplantation suppresses immunotolerant environment in tumors and induces antitumor immunity.2011
- Author(s)
  Udagawa T, Narumi K, Ikarashi Y, Ohnami S, Yoshida T, Aoki K
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] In vivo delivery of interferon-αgene enhances tumor immunity and suppresses immunotolerance after autologous hematopoietic stem cell transplantation2011
- Author(s)
  K Narumi, T Udagawa, Y Ikarashi, T Ochiya, T Yoshida, K Aoki
- Organizer
  The American Society of Gene Therapy's 14th Annual Meeting
- Place of Presentation
  Seattle
- Data Source
  KAKENHI-PROJECT-23590384
[Presentation] Syngeneic hematopoietic stem cell transplantation enhances the antitumor immunity of type I interferon gene transfer for sarcoma.2011
- Author(s)
  Udagawa T, Narumi K, Ochiya T, Yoshida T, Aoki K
- Organizer
  第17回日本遺伝子治療学会学術集会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23590384

1. HAMA Seiji (40397980)

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2. 星正治 (50099090)

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3. 切畑光統 (60128767)

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4. Sadahiro Ryoichi (70571644)

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5. 栗栖薫 (70201473)

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6. 遠藤暁 (90243609)

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7. 黒澤真城 (10462681)

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8. 服部能英 (50514460)

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9. 齋藤太一 (40457247)

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10. TAKAYASU Takeshi (20760755)

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11. USUI Satoru (00571803)

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12. 元井紀子 (70292878)

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13. 石井源一郎 (00270869)

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14. 吉田達哉 (10729338)

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15. 大江裕一郎 (20233041)

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16. 田丸淳一 (30188429)

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17. 白澤昌之 (40898996)

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18. 吉田裕 (70750751)

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19. 河野隆志 (80280783)

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20. 渡辺俊一 (80303303)

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21. 浜本隆二 (80321800)

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22. 神田浩明 (90260067)

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23. 松岡弘道 (20425078)

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24. 平岡伸介 (40276217)

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25. 関根圭輔 (00323569)

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26. 堀江信貴 (70380912)

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27. KITANO Shigehisa

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28. 五十嵐美徳

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29. 坂下信悟

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30. 竹下文隆

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AOKI Kazunori 青木 一教

Research Projects

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Co-Researchers

Vascular roles in tumor immune microenvironment of pancreatic and biliary cancers

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Development of neutron capture therapy using adenovirus genome-terminal protein complex for drug delivery

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術後せん妄発症を制御する免疫ランドスケープの解明

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Modulation of Immune suppressive tumor microenvironment based on inhibition of interaction between CAF and Treg in pancreatic cancerPrincipal Investigator

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Development study on pathological predictive biomarkers for cancer treatment

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Clinical application of boron-conjugated adenovirus vector for neutron capture therapy

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Exploration of biomarkers predicting onset of postoperative delirium following surgical cancer resection

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Development of chemo-immunotherapy based on the characterization of tumor-infiltrating myeloid-derived suppressor cellsPrincipal Investigator

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Development of targeting adenovirus vector as boron carrier for boron neutron capture therapy

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Development of immunosuppressive microenvironment-breaking immune therapy with autologous hematopoietic stem cell transplantationPrincipal Investigator

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[Book] Cellular and Genetic Practices for Translational Medicine2011

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[Book] Combination of immune gene therapy with allogeneic hematopoietic stem cell transplantation against solid cancers. In : Cellular and Genetic Practices for Translational Medicine ed. by J-Y. Kwak and J-Y2011

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[Journal Article] Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer2024

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[Journal Article] An algorithm-based technique for counting mitochondria in cells using immunohistochemical staining of formalin-fixed and paraffin-embedded sections2024

Author(s)

AOKI Kazunori 青木一教