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HADANO SHINJI  秦野 伸二

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HADANO Shinji  秦野 伸二

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Researcher Number 60281375
External Links
Affiliation (Current) 2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2011 – 2024: 東海大学, 医学部, 教授
2007 – 2009: Tokai University, School of Medicine, Associate Professor
2005 – 2006: 東海大学, 医学部, 助教授
2004: Tokai University, Medical Research Institute, Associate Professor, 総合医学研究所, 助教授
2000 – 2003: 東海大学, 総合医学研究所, 講師
1998 – 1999: 東海大学, 総合医学研究所, 助手
Review Section/Research Field
Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Medium-sized Section 52:General internal medicine and related fields / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / Biological Sciences
Except Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Respiratory organ internal medicine / Biological Sciences / Structural biochemistry / 遺伝
Keywords
Principal Investigator
運動ニューロン / 筋萎縮性側索硬化症 / 脳神経疾患 / マイクロ流体デバイス / 脳・神経 / ALS2 / 神経科学 / 蛋白質 / グアニンヌクレオチド交換因子 / 神経変性疾患 … More / ALS2遺伝子 / iPS細胞 / guanine nucleotide exchange factor / neurodegenerative disease / motor neuron / 酸化ストレス / 動物 / 遺伝子 / エンドゾーム / 低分子量Gタンパク質 / ALS2タンパク質 / 選択的細胞死 / 治療薬 / 標的分子シグナル系 / 血液脳関門 / 細胞内オルガネラ動態 / endosome / model animal / the ALS2 gene / amyotrophic lateral sclerosis / AIS2遺伝子 / エンドソ-ム / ALS2蛋白質 / モデル動物 / vesicle trafficking / small GTPase / ALS2 gene / familial ALS / amyotrophic laterel sclerosis / タンパク質ドメイン / 細胞内膜・小胞移送 / 細胞内膜小胞移送 / 家族性ALS / 筋萎縮性側索硬化症(ALS) / ALS / 蛋白質分解 / 遺伝子発現 / 脳・神経 / トランスレーショナルリサーチ / Nrf2 / p62/SQSTM1 / SOD1 / マウスモデル / オートファジー / エフェクター / 筋委縮性側索硬化症 / Rac1 / Rab5 / マクロピノサイトーシス / 運動ニューロン疾患 / シグナル伝達 / 生体膜輸送 / シグナル伝逹 / 神経生物学 / 細胞 / 分子 … More
Except Principal Investigator
ヒト / タンデムリピート / サテライトDNA / 反復配列 / ゲノム / ALS / iPS細胞 / CAGリピート / huntingtin / 4p15 / ハンチントン病 / deubiquitinating enzyme / repetitive sequence / 超可変性,ゲノム / ジーンコンバージョン / 不安定性,ゲノム / 細胞モデル / 骨格筋 / 下位運動ニューロン / 上位運動ニューロン / 筋萎縮性側索硬化症 / AD / シグナル伝達 / Rab タンパク質 / エンドソーム / 神経変性疾患 / 神経細胞 / Rab5 / 初期エンドソーム / 機能不全免疫系細胞 / マイクロRNA / 進行肺癌 / 制御性T細胞 / 次世代シークエンサー / フローサイトメーター / 腫瘍免疫 / マイクロRNA / リンパ球 / 免疫異常 / 肺癌 / transgenic / miniature pig / HD gene / gene expression control / polyglutamine disease / neuronal cell death / Huntignton's disease / ハンチントン舞踏病 / HD遺伝子転写調節 / HDモデルミニブタ / HD遺伝子転写制御 / ハンチントン病(HD) / トランスジェニック / ミニブタ / HD遺伝子 / 遺伝子発現調節 / ポリグルタミン病 / 神経細胞死 / antisense RNA / megasatellite / ubiquitin / ポリグルタミン / アンチセンスRNA / メガサテライト / 反復DNA配列 / 脱ユビキチン化酵素 / ユビキチン / gene conversion / evolution / tandem repeat / human genome / hypervariability / satellite DNA / genome / 分子進化 / 遺伝的不安定性 / ゲノム構造 / げっ歯類 / 高等動物 / メガサテライトDNA / 進化 / 超可変性 / 多型 / モデル動物 Less
  • Research Projects

    (18 results)
  • Research Products

    (277 results)
  • Co-Researchers

    (18 People)
  •  Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systemsPrincipal Investigator

    • Principal Investigator
      秦野 伸二
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokai University
  •  生理的機能を有するALS細胞モデルの構築とその病態解析

    • Principal Investigator
      大友 麻子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokai University
  •  A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrierPrincipal Investigator

    • Principal Investigator
      秦野 伸二
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Tokai University
  •  Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomes

    • Principal Investigator
      Otomo Asako
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokai University
  •  An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALSPrincipal Investigator

    • Principal Investigator
      Hadano Shinji
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokai University
  •  Elucidation of microRNAs causing immune cell dysfunction by next generation sequencer in patients with lung cancer

    • Principal Investigator
      AOKI Takuya
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Tokai University
  •  Molecular mechanism for the maintenance of proteostasis in motor neuronsPrincipal Investigator

    • Principal Investigator
      HADANO SHINJI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokai University
  •  Toward a development of the novel drug-screening system based on monitoring autophagy dynamicsPrincipal Investigator

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokai University
  •  Towards a comprehensive understanding of molecular pathogenesis for amyotrophic lateral sclerosisPrincipal Investigator

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokai University
  •  Elucidation of the physiological function of ALS2 and mechanism for motor neuron degeneration through the identification of ALS2 activatorsPrincipal Investigator

    • Principal Investigator
      HADANO Shinji, 國田 竜太
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai University
  •  ALS2遺伝子の機能喪失変異による運動ニューロン疾患発症機序に関する研究Principal Investigator

    • Principal Investigator
      秦野 伸二
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Generation of novel animal models for amyofrophic lateral sclerosis and studies on the molecular mechanisms underlying motor dysfunctionPrincipal Investigator

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai University
  •  Study on the cellular distribution and molecular function of ALS2, a product of the novel causative gene for famrlial ALSPrincipal Investigator

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai University
  •  Molecular Pathogenesis of Huntington's Disease and Molecular Mechanism of Neuronal Cell Death

    • Principal Investigator
      IKEDA Joh-E
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  高等動物の大きなタンデム反復配列内および近傍における組換え

    • Principal Investigator
      GONDO Yoichi
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The Institute of Physical and Chemical Research
  •  ヒトメガサテライトDNAのゲノム構造と超可変性

    • Principal Investigator
      権藤 洋一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The Institute of Physical and Chemical Research
  •  STRUCTURAL ANALYSIS OF RS447 MEGASATELLITE DNA.

    • Principal Investigator
      GONDO Yoichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      遺伝
    • Research Institution
      RIKEN
      Tokai University
  •  ubiquitin-huntingtin nuclear inclusion body formation

    • Principal Investigator
      SAITOH Yasushi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      IWATE UNIVERSITY
      Tokai University

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All Journal Article Presentation Book

  • [Book] Autophagy dysfunction in Alzheimer's disease and dementia/ Chapter 1 Degradation mechanisms of cells2022

    • Author(s)
      Otomo, A. and Hadano, S. (Edited by Hamano, T. and Mutoh, T.)
    • Total Pages
      19
    • Publisher
      ACADEMIC PRESS (Elsevier)
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Book] Autophagy Dysfunction in Alzheimer's Disease and Dementia 担当:共著, 範囲:1. Degradation mechanisms of cells (Edited by Tadanori Hamano & Tatsuro Mutoh)2022

    • Author(s)
      Asako Otomo, Shinji Hadano
    • Total Pages
      356
    • Publisher
      ELSEVIER/Academic Press
    • ISBN
      9780323899062
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Book] ALS2/Alsin,アクチュアル脳・神経疾患の臨床「すべてがわかるALS・運動ニューロン疾患」IV. ALS の病態関連遺伝子と遺伝子変異, 辻省次, 祖父江元編2013

    • Author(s)
      大友麻子, 白川健太郎, 宮嶋裕明, 秦野伸二
    • Publisher
      中山書店, 東京
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Book] ALS2/Alsin、アクチュアル脳・神経疾患の臨床「すべてがわかるALS・運動ニューロン疾患」IV. ALSの病態関連遺伝子と遺伝子変異、辻省次、祖父江元編2013

    • Author(s)
      大友麻子、白川健太郎、宮嶋裕明、秦野伸二
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Book] ALS2/Alsin、アクチュアル脳・神経疾患の臨床「すべてがわかるALS・運動ニューロン疾患」IV. ALSの病態関連遺伝子と遺伝子変異、辻省次、祖父江元編2013

    • Author(s)
      大友麻子、白川健太郎、宮嶋裕明、秦野伸二
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Book] 筋萎縮性側索硬化症原因遺伝子, 予防医学事典(松島 繹治, 酒井 敏行, 石川 昌, 稲寺 秀邦編)2005

    • Author(s)
      秦野 伸二
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Book] 筋萎縮性側索硬化症原因遺伝子、予防医学事典(松島綱治、酒井敏行、石川昌、稲寺秀邦 編)2005

    • Author(s)
      秦野 伸二
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17025039
  • [Book] 筋萎縮性側索硬化症原因遺伝子、予防医学事典(松島綱治、酒井敏行、石川昌、稲寺秀邦 編)2005

    • Author(s)
      秦野 伸二
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Book] 予防医学事典(松島網治, 酒井敏行, 石川昌, 稲寺秀邦編)、116.筋萎縮性側索硬化症原因遺伝子2005

    • Author(s)
      秦野 伸二(分担著)
    • Publisher
      朝倉書店、東京(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Book] 脳機能の解明-生命科学の主潮流-(赤池紀扶, 東英穂, 阿部康二, 久保千春編)、第8章神経変性疾患の遺伝子異常と病態解明、家族性筋萎縮性側策硬化症2型(ALS2)の原因遺伝子2002

    • Author(s)
      秦野 伸二(分担著)
    • Publisher
      ガイア出版会、福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.2024

    • Author(s)
      Nami Motosugi , Akiko Sugiyama , Asako Otomo , Yuka Sakata , Takuma Araki , Shinji Hadano , Natsuhiko Kumasaka , Atsushi Fukuda
    • Journal Title

      PNAS nexus

      Volume: 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Journal Article] Genetic and clinical characteristics of ALS patients with NEK1 gene variants2023

    • Author(s)
      Jiang Qirui、Lin Junyu、Wei Qianqian、Li Chunyu、Hou Yanbing、Zhang Lingyu、Ou Ruwei、Liu Kuncheng、Yang Tianmi、Xiao Yi、Hadano Shinji、Shang Huifang
    • Journal Title

      Neurobiology of Aging

      Volume: 123 Pages: 191-199

    • DOI

      10.1016/j.neurobiolaging.2022.11.001

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Journal Article] Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes2023

    • Author(s)
      Sato Kai、Suzuki-Utsunomiya Kyoko、Mitsui Shun、Ono Suzuka、Shimakura Kento、Otomo Asako、Hadano Shinji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 638 Pages: 168-175

    • DOI

      10.1016/j.bbrc.2022.11.061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
  • [Journal Article] High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device2022

    • Author(s)
      Otomo Asako、Ono Suzuka、Sato Kai、Mitsui Shun、Shimakura Kento、Kimura Hiroshi、Hadano Shinji
    • Journal Title

      Neuroscience Research

      Volume: 174 Pages: 46-52

    • DOI

      10.1016/j.neures.2021.07.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
  • [Journal Article] Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies2022

    • Author(s)
      Rossi Sebastiano Matteo、Ermondi Giuseppe、Sato Kai、Otomo Asako、Hadano Shinji、Caron Giulia
    • Journal Title

      Molecules

      Volume: 27 Issue: 20 Pages: 7063-7063

    • DOI

      10.3390/molecules27207063

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
  • [Journal Article] AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin2022

    • Author(s)
      Rossi Sebastiano Matteo、Ermondi Giuseppe、Hadano Shinji、Caron Giulia
    • Journal Title

      Drug Discovery Today

      Volume: 27 Issue: 6 Pages: 1652-1660

    • DOI

      10.1016/j.drudis.2021.12.018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Journal Article] SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron2022

    • Author(s)
      Mitsui Shun、Otomo Asako、Sato Kai、Ishiyama Masahito、Shimakura Kento、Okada-Yamaguchi Chisa、Warabi Eiji、Yanagawa Toru、Aoki Masashi、Shang Hui-Fang、Hadano Shinji
    • Journal Title

      Neurochemistry International

      Volume: 158 Pages: 105364-105364

    • DOI

      10.1016/j.neuint.2022.105364

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07356, KAKENHI-PROJECT-19H03551
  • [Journal Article] De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs2022

    • Author(s)
      Motosugi Nami、Sugiyama Akiko、Okada Chisa、Otomo Asako、Umezawa Akihiro、Akutsu Hidenori、Hadano Shinji、Fukuda Atsushi
    • Journal Title

      Cell Reports Methods

      Volume: 2 Issue: 12 Pages: 100352-100352

    • DOI

      10.1016/j.crmeth.2022.100352

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09555, KAKENHI-PROJECT-22K19409, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-19H03551, KAKENHI-PROJECT-20H03829
  • [Journal Article] The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS22021

    • Author(s)
      Shimakura Kento、Sato Kai、Mitsui Shun、Ono Suzuka、Otomo Asako、Hadano Shinji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 569 Pages: 106-111

    • DOI

      10.1016/j.bbrc.2021.06.095

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
  • [Journal Article] SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells2021

    • Author(s)
      Nozaki Masahisa、Otomo Asako、Mitsui Shun、Ono Suzuka、Shirakawa Ryohei、Chen YongPing、Hama Yutaro、Sato Kai、Chen XuePing、Suzuki Toshiyasu、Shang Hui-Fang、Hadano Shinji
    • Journal Title

      eNeurologicalSci

      Volume: 22 Pages: 100301-100301

    • DOI

      10.1016/j.ensci.2020.100301

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551, KAKENHI-PROJECT-18J20411
  • [Journal Article] ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes2020

    • Author(s)
      Ono Suzuka、Otomo Asako、Murakoshi Shuji、Mitsui Shun、Sato Kai、Fukuda Mitsunori、Hadano Shinji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Issue: 4 Pages: 908-915

    • DOI

      10.1016/j.bbrc.2019.12.122

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
  • [Journal Article] オートファジーと神経変性疾患 ― 筋萎縮性側索硬化症(ALS)と前頭側頭型認知症(FTD)を中心として2020

    • Author(s)
      秦野伸二
    • Journal Title

      医学のあゆみ

      Volume: 272 Pages: 885-891

    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Journal Article] Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss2020

    • Author(s)
      Oka A、Takagi A、Komiyama E、Yoshihara N、Mano S、Hosomichi K、Suzuki S、Haida Y、Motosugi N、Hatanaka T、Kimura M、Ueda M、Nakagawa S、Miura H、Ohtsuka M、Tanaka M、Komiyama T、Otomo A、Hadano S、Mabuchi T、Beck S、Inoko H、Ikeda S.
    • Journal Title

      EBioMedicine

      Volume: 57 Pages: 102810-102810

    • DOI

      10.1016/j.ebiom.2020.102810

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19K08802, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H03551
  • [Journal Article] Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures.2020

    • Author(s)
      Otomo Asako、Takahashi Ueda Mahoko、Fujie Toshinori、Hasebe Arihiro、Suematsu Yoshitaka、Okamura Yosuke、Takeoka Shinji、Hadano Shinji、Nakagawa So
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 6716-6716

    • DOI

      10.1038/s41598-020-63537-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K20116, KAKENHI-PROJECT-19K07832, KAKENHI-PLANNED-18H05469, KAKENHI-PROJECT-19H03551
  • [Journal Article] Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B2020

    • Author(s)
      Hayashi Hideki、Wang Ting、Tanaka Masayuki、Ogiwara Sanae、Okada Chisa、Ito Masatoshi、Fukunishi Nahoko、Iida Yumi、Nakamura Ayaka、Sasaki Ayumi、Amano Shunji、Yoshida Kazuhiro、Otomo Asako、Ohtsuka Masato、Hadano Shinji
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 6 Pages: e0234180-e0234180

    • DOI

      10.1371/journal.pone.0234180

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
  • [Journal Article] Theme 3 In vitro experimental models: ALS2 along with a novel ALS2 interacting protein RAB30 regulates morphological integrity and functions of the Golgi apparatus2019

    • Author(s)
      Otomo A、Onodera W、Murakoshi S、 Matsui K、 Sato K、 Mitsui S、Ono S、Fukuda M、Hadano S.
    • Journal Title

      Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

      Volume: 20 Issue: sup1 Pages: 136-137

    • DOI

      10.1080/21678421.2019.1646991

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832
  • [Journal Article] An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons2019

    • Author(s)
      Yokoyama S.、Otomo A.、Hadano S.、Kimura H.
    • Journal Title

      Biomicrofluidics

      Volume: 13 Issue: 3 Pages: 034104-034104

    • DOI

      10.1063/1.5090968

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07832, KAKENHI-PROJECT-19H03551
  • [Journal Article] Inositol hexakisphosphate kinase 2 is a pre-symptomatic biomarker for amyotrophic lateral sclerosis.2017

    • Author(s)
      Moriya, Y., Nagata, E., Fujii, N., Satoh, T., Ogawa, H., Hadano, S., and Takizawa, S.
    • Journal Title

      Tokai J. Exp. Clin. Med.

      Volume: 42 Pages: 13-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Journal Article] Mutation screening of the CHCHD10 gene in Chinese patients with amyotrophic lateral sclerosis.2017

    • Author(s)
      Zhou, Q. Q., Chen, Y. P., Wei, Q. -Q., Cao, B., Wu, Y., Zhao, B., Ou, R. W., Yang, J., Chen, X. P., Hadano, S., and Shang, H. -F.
    • Journal Title

      Mol. Neurobiol

      Volume: 印刷中 Issue: 5 Pages: 3189-3194

    • DOI

      10.1007/s12035-016-9888-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Journal Article] Aberration of miRNAs expression in leukocytes from sporadic amyotrophic lateral sclerosis.2016

    • Author(s)
      Chen, Y. P., Wei, Q. Q., Chen, X. P., Li, C. Y., Cao, B., Ou, R. W., Hadano, S., and Shang, H. -F.
    • Journal Title

      Front. Mol. Neurosci.

      Volume: 9

    • DOI

      10.3389/fnmol.2016.00069

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Journal Article] Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice2016

    • Author(s)
      Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F
    • Journal Title

      Hum. Mol. Genet.

      Volume: 25 Issue: 15 Pages: 3321-3340

    • DOI

      10.1093/hmg/ddw180

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26290018, KAKENHI-PROJECT-26460485
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11094, KAKENHI-PROJECT-15K14681, KAKENHI-PROJECT-15K14951, KAKENHI-PUBLICLY-15H01239, KAKENHI-PUBLICLY-15H01380, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111501, KAKENHI-PUBLICLY-26111503, KAKENHI-PUBLICLY-26111505, KAKENHI-PUBLICLY-26111514, KAKENHI-PUBLICLY-26111521, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-15H05298, KAKENHI-PROJECT-15H06095, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25461364, KAKENHI-PROJECT-25462920, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26670906, KAKENHI-PROJECT-25850198, KAKENHI-PROJECT-25290014, KAKENHI-PROJECT-25291040, KAKENHI-PROJECT-25291042, KAKENHI-PROJECT-25293383, KAKENHI-PROJECT-26290018, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-26292032, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-26713005, KAKENHI-PUBLICLY-15H01545, KAKENHI-PUBLICLY-15H01572, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26253094, KAKENHI-PROJECT-16H05291, KAKENHI-PROJECT-16J00431, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26293207, KAKENHI-PROJECT-25711005, KAKENHI-PROJECT-26430050, KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-15K08376, KAKENHI-PROJECT-15K10908, KAKENHI-PROJECT-15K11079, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K15790, KAKENHI-PROJECT-16K15853, KAKENHI-PROJECT-15K16486, KAKENHI-PROJECT-16H05107, KAKENHI-PROJECT-20H03453
  • [Journal Article] Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort.2015

    • Author(s)
      Yang, Y., Tang, L., Zhang, N., Pan, L., Hadano, S., and Fan, D. -S.
    • Journal Title

      Amyotroph. Lateral Scler. Frontotempo. Degen.

      Volume: in press Issue: 5-6 Pages: 378-384

    • DOI

      10.3109/21678421.2015.1009466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24650189, KAKENHI-PROJECT-26290018
  • [Journal Article] SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis.2014

    • Author(s)
      Chen, Y. P., Zheng, Z. Z., Chen, X. P., Huang, R., Yang, Y., Yuan, L. X., Pan, L., Hadano, S., and Shang, H. -F.
    • Journal Title

      Neurobiol. Aging

      Volume: 35 Issue: 3 Pages: 726.e7-726.e9

    • DOI

      10.1016/j.neurobiolaging.2013.09.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129, KAKENHI-PROJECT-24650189
  • [Journal Article] SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis2014

    • Author(s)
      Chen Y. P, Zheng Z. Z, Chen X. P, Huang R, Yang Y, Yuan L. X, Pan L, Hadano S, and Shang H. F
    • Journal Title

      Neurobiol. Aging

      Volume: 35(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Journal Article] A novel small-molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2 -(2,4,6-trimethylphenoxy)acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway : Therapeutic implications for ALS2012

    • Author(s)
      Kanno T, Tanaka K, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, Hirayama N, and Ikeda J. E
    • Journal Title

      Free Radical Biol. Med

      Volume: 53(11) Pages: 2028-2042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Journal Article] Different human copper-zinc superoxide dismutase mutants, SOD1^<G93A> and SOD1^<H46R>, exert distinct harmful effects on gross phenotype in mice2012

    • Author(s)
      Pan L, Yoshii Y, Otomo A, Ogawa H, Iwasaki Y, Shang H. F, Hadano S
    • Journal Title

      PLoS ONE

      Volume: 7(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Journal Article] Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases2012

    • Author(s)
      Otomo A, Pan L, and Hadano S
    • Journal Title

      Neurol. Res. Int

      Volume: 2012 Pages: 498428-498428

    • DOI

      10.1155/2012/498428

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129, KAKENHI-PROJECT-24650189
  • [Journal Article] Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F, and Ikeda J. -E.
    • Journal Title

      Exp. Neurol

      Volume: 232(1) Pages: 41-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Journal Article] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R> transgenic mouse model of ALS2011

    • Author(s)
      Yoshii Y, Otomo A, Pan L, Ohtsuka M, and Hadano S
    • Journal Title

      Neurosci. Res

      Volume: 70(3) Pages: 321-329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Journal Article] Loss of ALS2/alsin exacerbates motor dysfunction in a SOD1^<H46R>-expressing ALS mouse model by disturbing endolysosomal trafficking.2010

    • Author(s)
      Hadano, S.
    • Journal Title

      PLoS ONE 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Loss of ALS2/alsin exacerbates motor dysfunction in a SOD1H46R-expressing ALS mouse model by disturbing endolysosomal trafficking2010

    • Author(s)
      Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, Ikeda JE
    • Journal Title

      PLoS ONE 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Natural history of young-adult amyotrophic lateral sclerosis2009

    • Author(s)
      Yoshii Y, Hadano S, Otomo A, Suzuki K, Ikeda K, Ikeda JE, Iwasaki Y
    • Journal Title

      Neurology 73

      Pages: 648-649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth2008

    • Author(s)
      Otomo A, Kunita R, Suzuki-Utsunomiya K, Mizumura H, Onoe K, Osuga H, Hadano S, Ikeda JE
    • Journal Title

      Biochem Biophys Res Commn 370

      Pages: 87-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] ALS2遺伝子変異に起因する運動ニューロン疾患.2008

    • Author(s)
      秦野伸二
    • Journal Title

      Clinical Neuroscience 26

      Pages: 323-324

    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] A dopamine receptor antagonist L-745, 870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice2008

    • Author(s)
      Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, Ikeda JE
    • Journal Title

      Exp Neurol 211

      Pages: 378-386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] ALS2遺伝子変異に起因する運動ニューロン疾患2008

    • Author(s)
      秦野 伸二
    • Journal Title

      Clinical Neuroscience 26

      Pages: 323-324

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Motor neuron diseases caused by the ALS2 mutations2008

    • Author(s)
      Hadano, S
    • Journal Title

      Clin. Neurosci 26

      Pages: 323-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics2007

    • Author(s)
      Suzuki-Utsunomiya K, Hadano S, Otomo A, Kunita R, Mizumura H, Osuga H, Ikeda JE
    • Journal Title

      Biochem Biophys Res Commn 354

      Pages: 491-497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration2007

    • Author(s)
      秦野 伸二
    • Journal Title

      NEUROCHEMISTRY International 51

      Pages: 74-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration2007

    • Author(s)
      Hadano, S
    • Journal Title

      Neurochem. Int. 51

      Pages: 74-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis2007

    • Author(s)
      Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
    • Journal Title

      J Biol Chem 282

      Pages: 16599-16611

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Molecular and cellular function of ALS2/alsin:Implication of membrane dynamics in neuronal development and degeneration2007

    • Author(s)
      Shinji Hadano
    • Journal Title

      Neurochem.Int. 51

      Pages: 74-84

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration2007

    • Author(s)
      Hadano S, Kunita R, Otomo A, Suzuki-Utsunomiya K, Ikeda JE
    • Journal Title

      Neurochem Int 51

      Pages: 74-84

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Journal Article] Molecular and cellular function of ALS2/alsin : Implication of membrane dynamics in neuronal development and degeneration2007

    • Author(s)
      Hadano, S., et. al.
    • Journal Title

      Neurochem. Int 51

      Pages: 74-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Shinji Hadano
    • Journal Title

      Hum.Mol.Genet. 15・2

      Pages: 233-250

    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] 神経系疾患の遺伝子学2006

    • Author(s)
      秦野 伸二
    • Journal Title

      最新医学 61

      Pages: 1956-1970

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Recent advances in molecular studies on neurodegenerative diseases2006

    • Author(s)
      Hadano, S., Ikeda, J.E
    • Journal Title

      Saishin Igaku 61

      Pages: 1956-1970

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Shinji Hadano
    • Journal Title

      Hum.Mol.Genet. 15

      Pages: 233-250

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] ice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S., et. al.
    • Journal Title

      Hum. Mol. Genet 15

      Pages: 233-250

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Shinji Hadano
    • Journal Title

      Hum.Mol.Genet. 15・2

      Pages: 233-250

    • Data Source
      KAKENHI-PROJECT-17025039
  • [Journal Article] Genes for amyotrophic lateral sclerosis.2005

    • Author(s)
      Hadano, S.
    • Journal Title

      Yobou Igaku Jiten (Asakura Publisher) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Purification and functional analyses of ALS2 and its homologue2005

    • Author(s)
      Shinji Hadano
    • Journal Title

      Methods in Enzymology 403

      Pages: 310-321

    • Data Source
      KAKENHI-PROJECT-17025039
  • [Journal Article] A Dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.2005

    • Author(s)
      Okada, Y., Sakai, H., Kohiki, E., Suga, E., Yanagisawa, Y., Tanaka, K., Hadano, S., Osuga, H., Ikeda, J.-E.
    • Journal Title

      J.Cereb.Blood Flow Metab. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Purification and functional analyses of ALS2 and its homologue2005

    • Author(s)
      Hadano, S., Ikeda, J.E
    • Journal Title

      Methods Enzymol 403

      Pages: 310-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Genes associated with amyotrophic lateral sclerosis2005

    • Author(s)
      Hadano, S
    • Journal Title

      Yobo Igaku Jiten, Edited by Matsusshima T, Sakai T, Ishikawa M, and Inadera H, Asakura-Shoten

      Pages: 251-253

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] Purification and functional analyses of ALS2 and its homologue2005

    • Author(s)
      Shinji Hadano
    • Journal Title

      Methods in Enzymology 403

      Pages: 310-321

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Journal Article] (2004) Homo-oligomerization of ALS2 through its unique carboxy-terminal region is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking.2004

    • Author(s)
      Kunita, R., Otomo, A., Mizumura, H., Suzuki, K., Showguchi-Miyata, J., Yanagisawa, Y., Hadano, S., Ikeda, J.-E.
    • Journal Title

      J.Biol.Chem. 279 (37)

      Pages: 38626-38635

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.2004

    • Author(s)
      Shinji Hadano
    • Journal Title

      FEBS Lett. 575

      Pages: 64-70

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.2004

    • Author(s)
      Hadano, S., Otomo, A., Suzuki-Utsunomiya, K., Kunita, R., Yanagisawa, Y., Showguchi-Miyata, J., Mizumura, H., Ikeda, J.-E.
    • Journal Title

      FEBS Lett. 575 (1-3)

      Pages: 64-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.2004

    • Author(s)
      Shinji Hadano
    • Journal Title

      FEBS Lett. 575・1-3

      Pages: 64-70

    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis.2003

    • Author(s)
      Nagano, I., Murakami, T., Shiote, M., Manabe, Y., Hadano, S., Yanagisawa, Y., Ikeda, J.-E., Abe, K.
    • Journal Title

      Neurol.Res. 25 (5)

      Pages: 505-509

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2, the novel gene for a form of recessive amyotrophic lateral sclerosis. -implication in the pathogenesis for motor neuron diseases.2003

    • Author(s)
      Hadano, S.
    • Journal Title

      Igaku no Ayumi 205 (2)

      Pages: 119-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.2003

    • Author(s)
      Otomo, A., Hadano, S., Okada, T., Mizumura, H., Kunita, R., Nishijima, H., Showguchi-Miyata, J., Yanagisawa, Y., Kohiki, E., Suga, E., Yasuda, M., Osuga, H., Nishimoto, T., Naurumiya, S., Ikeda, J.-E.
    • Journal Title

      Hum.Mol.Genet. 12 (14)

      Pages: 1671-1687

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] 新しい家族性筋萎縮性側索硬化症遺伝子:ALS2-運動ニューロン疾患における分子接点2003

    • Author(s)
      秦野 伸二
    • Journal Title

      医学のあゆみ 205

      Pages: 119-123

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.2002

    • Author(s)
      Singaraja, R.R., Hadano, S., Metzler, M., Givan, S., Wellington, C.L, Warby, S., Yanai, A., Gutekunst, C.-A., Leavitt, B.R., Yi, H., Fichter, K., Gan, L, McCutcheon, K., Chopra, V., Michel, J., Hersch, S.M., Ikeda, J.-E., Hayden, M.R.
    • Journal Title

      Hum.Mol.Genet. 11 (23)

      Pages: 2815-2828

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] 筋萎縮性側索硬化症原因遺伝子の同定とゲノム研究2002

    • Author(s)
      秦野 伸二
    • Journal Title

      ゲノム医学 2

      Pages: 231-240

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] The novel gene for the familial ALS.2002

    • Author(s)
      Hadano, S.
    • Journal Title

      BRAIN MEDICAL 14 (1)

      Pages: 47-54

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Functional human NAIP promoter and transcriptional elements of the human NAIP and ΨNAIP gene2002

    • Author(s)
      Xu, M., Okada, T., Sakai, H., Miyamoto, N., Yanagisawa, Y., MacKenzie, A.E., Hadano, S., Ikeda, J.-E.
    • Journal Title

      Biochim.Biophys.Acta 1574 (1)

      Pages: 35-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Genetic and genomic approaches for identification of genes underlying amyotrophic lateral sclerosis.2002

    • Author(s)
      Hadano, S.
    • Journal Title

      Genome Med. 2 (3)

      Pages: 231-240

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Causative genes for familial amyotrophic lateral sclerosis.2002

    • Author(s)
      Hadano, S.
    • Journal Title

      Seikagaku 74 (6)

      Pages: 483-489

    • NAID

      10008692567

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 gene encoding a functional deubiquitinating enzyme.2002

    • Author(s)
      Okada, T., Gondo, Y., Goto, J., Kanazawa, I., Hadano, S., Ikeda, J.-E.
    • Journal Title

      Hum.Genet. 110 (4)

      Pages: 302-313

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] The causative gene for familial ALS2.2002

    • Author(s)
      Hadano, S., Ikeda, J.-E.
    • Journal Title

      Nou Kinou No Kaimei (Gaia Publisher)

      Pages: 299-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALSの原因遺伝子2002

    • Author(s)
      秦野 伸二
    • Journal Title

      生化学 74

      Pages: 483-489

    • NAID

      10008692567

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] 家族性ALSの新たな遺伝子2002

    • Author(s)
      秦野 伸二
    • Journal Title

      BRAIN MEDICAL 14

      Pages: 47-54

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.2001

    • Author(s)
      Hadano, S. et al.
    • Journal Title

      Nat. Genet. 29(2)

      Pages: 166-173

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210018
  • [Journal Article] A gene encoding a putative GTPase regulator is mutated in familial amyotrophicateral sclerosis 2.2001

    • Author(s)
      Hadano, S. et al.
    • Journal Title

      Nat Genet. 29(2)

      Pages: 166-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210018
  • [Presentation] PDIはTDP-43のグアニン四重鎖依存的液液相分離を制御する2023

    • Author(s)
      石黒亮、西島恵子、村上裕太、木村啓志、秦野伸二、大友麻子
    • Organizer
      第46回日本分子生物学会年会 (MBSJ2023)
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] FUS遺伝子変異を原因とする筋萎縮性側索硬化症(ALS)細胞モデルの作出と マイクロデバイスを用いた軸索表現型の評価2023

    • Author(s)
      西島 恵子、大友 麻子、村上 裕太、石川 充、木村 啓志、秦野 伸二
    • Organizer
      15th Tokai University Micro/Nano Enlightenment
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1の時空間的動態解析2023

    • Author(s)
      島倉 健人、山口千沙、湯田平 陽香、 岡 晃、大友 麻子、秦野 伸二
    • Organizer
      第46回日本分子生物学会年会 (MBSJ2023)
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] マイクロデバイスを用いたFUS遺伝子変異を原因とする筋萎縮性側索硬化症(ALS)細胞モデルの評価2023

    • Author(s)
      大友 麻子、西島 恵子、村上 裕太、石川 充、木村 啓志、秦野 伸二
    • Organizer
      第46回日本分子生物学会年会 (MBSJ2023)
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] ヒトiPSCs由来下位運動ニューロンの培養と軸索表現型評価に適したマイクロデバイスの開発2022

    • Author(s)
      大友麻子、西島恵子、村上裕太、石川充、木村啓志、秦野伸二
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 下位運動ニューロンと骨格筋の共培養による神経筋結合部の構築とその機能評価2022

    • Author(s)
      内藤佳津子、大友麻子、村松優作、西島恵子、木村啓志、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第14回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] マウス由来骨格筋とヒト由来下位運動ニューロンの共培養による神経筋結合部の構築とその機能評価2022

    • Author(s)
      内藤佳津子、大友麻子、秦野伸二
    • Organizer
      日本実験動物技術者協会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 筋萎縮性側索硬化症責任遺伝子NEK1およびALS2の機能的連関が神経細胞表現型に及ぼす影響2022

    • Author(s)
      湯田平 陽香、佐藤 海、 島倉 健人、石川 充、大友 麻子、秦野 伸二
    • Organizer
      第45回日本分子生物学会年会 (MBSJ2022)
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] FTLD-ALS疾患スペクトラムにおけるオートファジー・エンドリソソーム分解系の異常2022

    • Author(s)
      秦野伸二
    • Organizer
      日本認知症学会/日本老年精神医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 筋萎縮性側索硬化症責任遺伝子NEK1およびALS2の機能的連関が神経細胞表現型に及ぼす影響2022

    • Author(s)
      湯田平陽香、佐藤海、島倉健人、石川充、大友麻子、秦野伸二
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1細胞内動態観察2022

    • Author(s)
      島倉 健人、山口 千沙、湯田平 陽香、岡 晃、大友 麻子、秦野 伸二
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] ヒトiPSCs由来下位運動ニューロンの培養と軸索表現型評価に適したマイクロデバイスの開発2022

    • Author(s)
      大友 麻子、西島 恵子、村上 裕太、石川 充、木村 啓志、秦野 伸二
    • Organizer
      第45回日本分子生物学会年会 (MBSJ2022)
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] Dysfunction of the autophagy-endolysosomal system in ALS and FTD2022

    • Author(s)
      Hadano, S.
    • Organizer
      日本神経学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 効率的下位運動ニューロン分化誘導法を用いたALS細胞モデルの作出2022

    • Author(s)
      西島恵子、大友麻子、村松優作、木村啓志、石川充、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第14回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 光変換蛍光タンパク質Dendra2を用いたSQSTM1細胞内動態観察2022

    • Author(s)
      島倉健人、岡田-山口千沙、湯田平陽香、岡晃、大友麻子、秦野伸二
    • Organizer
      本分子生物学会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 神経変性疾患のLLPS:光変換蛍光タンパク質Dendra2を用いたSQSTM1/p62-bodyの細胞内動態解析2022

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第18回研修会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] マウス由来骨格筋とヒト由来下位運動ニューロンの共培養による神経筋結合部の構築とその機能評価2022

    • Author(s)
      内藤 佳津子、大友 麻子、秦野伸二
    • Organizer
      第56回日本実験動物技術者協会総会
    • Data Source
      KAKENHI-PROJECT-22K07356
  • [Presentation] The intrinsically disordered region at the N-terminus of ALS2 acts as a determinant for the intracellular localization and oligomerization of ALS2.2021

    • Author(s)
      Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
    • Organizer
      PACTALS 2021 NAGOYA (Pan-Asian Consortium for Treatment and Research in ALS)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 筋萎縮性側索硬化症(ALS)細胞モデルの構築を目指した骨格筋及下位運動ニューロン培養法の確立2021

    • Author(s)
      内藤佳津子、加納葵、藤田紘暉、大友麻子、木村啓志、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第13回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 原始的な真核生物における形態変化に関与する分子の網羅的解析2021

    • Author(s)
      岡田-山口千沙、秦野伸二、荒木琢磨、佐々木亜由美、竹腰進、小濱一弘、金子堯子、中村彰男
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2の天然変性領域はALS2細胞内局在および多量体形成に影響する2021

    • Author(s)
      島倉健人、佐藤海、三井駿、小野鈴花、大友麻子、秦野伸二
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] マイクロ流体デバイスを用いた神経筋接合部モデルの確立2021

    • Author(s)
      加納葵、藤田紘暉、大友麻子、秦野伸二、木村啓志
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第13回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Neural cell-specific SQSTM1 deficiency exacerbates disease symptoms in a SOD1H46R-expressing ALS mouse model by regulating the formation and distribution of ubiquitin-positive aggregates in motor neurons.2021

    • Author(s)
      Mitsui, S., Otomo, A., Sato, K., Shimakura, K., Ishii, T., Yanagawa, T., Aoki, M., and Hadano, S.
    • Organizer
      第44回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Structural architecture and cellular functions of juvenile motor neuron disease-causative gene product ALS2: implication of endosome maturation and endocytic recycling.2021

    • Author(s)
      Otomo, A., Ono, S., Sato, K., Mitsui, S. Shimakura, K., Fukuda, M., and Hadano, S.
    • Organizer
      Keystone Symposia/eSymposia, Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2 forms a unique homophilic complex in the central nervous system, whose molecular weight is higher than those in the peripheral tissues.2021

    • Author(s)
      Sato, K., Suzuki-Utsunomiya, K., Mitsui, S., Yudahira, H., Ono, S., Shimakura, K., Otomo, A., and Hadano, S.
    • Organizer
      第44回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Structural architecture and cellular functions of juvenile motor neuron disease-causative gene product ALS2: implication of endosome maturation and endocytic recycling.2021

    • Author(s)
      Asako Otomo, Suzuka Ono, Kai Sato, Shun Mitsui, Kento Shimakura, Mitsunori Fukuda and Shinji Hadano
    • Organizer
      Keystone Symposia/eSymposia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07832
  • [Presentation] The intrinsically disordered region at the N-terminus of ALS2 acts as a determinant for the intracellular localization and oligomerization of ALS22021

    • Author(s)
      Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
    • Organizer
      第44回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 細胞内膜小胞トラフィッキング異常に焦点を当てた神経変性疾患新規薬剤スクリーニング系の開発2020

    • Author(s)
      秦野伸二
    • Organizer
      東海大学卓越研究員制度シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] SQSTM1の欠損は神経細胞と末梢組織細胞のユビキチン化タンパク質動態に異なった影響をもたらす2020

    • Author(s)
      三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.2020

    • Author(s)
      Sato, K., Otomo, A., Ueda, M. T., Hiratsuka, Y., Suzuki-Utsunomiya, K., Sugiyama, J., Murakoshi, S., Mitsui, S., Ono, S., Nakagawa, S., Shang, H. -F., and Hadano, S.
    • Organizer
      Experimental Biology 2020/2020 ASBMB Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 神経終末画分におけるALS2は細胞質画分とは異なる特異的高次構造を形成する2020

    • Author(s)
      佐藤海、鈴木-宇都宮恭子、三井駿、小野鈴花、島倉健人、大友麻子、秦野伸二
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Neural cell-specific SQSTM1 deficiency accelerates the onset of disease in an ALS mouse model.2020

    • Author(s)
      Mitsui, S., Ishiyama, M., Shimakura, K., Sato, K., Ono, S., Otomo, A., Ishii, T., Yanagawa, T., Aoki, M., and Hadano, S.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, Brain Therapeutics: Disruptive Technologies and Opportunities
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2 controls the intracellular localization of small GTPase Rab17 and regulates endosome maturation.2019

    • Author(s)
      Ono, S., Murakoshi, S., Sato, K., Mitsui, S., Otomo, A., Fukuda, M., and Hadano, S.
    • Organizer
      ASCB/EMBO 2019 meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2は神経終末画分において細胞質画分とは異なる特異的高次構造を形成する2019

    • Author(s)
      佐藤海、鈴木-宇都宮恭子、島倉健人、三井駿、小野鈴花、大友麻子、秦野伸二
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Phosphorylation state of ALS2/alsin alters its intracellular localization and endosome dynamics.2019

    • Author(s)
      Shimakura, K., Sato, K., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
    • Organizer
      30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 単量体Keima融合型LC3Bによるオートファジー・エンドリソソーム系モニタリング法の開発2019

    • Author(s)
      秦野伸二、林英樹、王テイ、田中政之、荻原早苗、岡田千沙、伊藤誠敏、福西菜穂子、飯田裕美、中村彩花、佐々木亜由美、天野俊二、吉田和弘、大友麻子、大塚正人
    • Organizer
      第12回オートファジー研究会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2疾患原因変異体の高次構造の変化はALS2が担うエンドソーム機能を喪失させる2019

    • Author(s)
      佐藤海、大友麻子、上田-高橋真保子、平塚結衣、鈴木-宇都宮恭子、杉山純也、村越秀治、三井駿、小野鈴花、中川草、Hui-Fang Shang、秦野伸二
    • Organizer
      第42回日本神経科学大会/第62回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALSマウスモデル由来初代神経培養細胞のマイクロデバイスを用いた定量的軸索輸送解析2019

    • Author(s)
      大友麻子、串田隆志、石田智之、荒木良介、三井駿、小野鈴花、佐藤海、木村啓志、秦野伸二
    • Organizer
      第42回日本神経科学大会/第62回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2 along with a novel ALS2 interacting protein RAB30 regulates morphological integrity and functions of the Golgi apparatus2019

    • Author(s)
      Otomo A、Onodera W、Murakoshi S、 Matsui K、 Sato K、 Mitsui S、Ono S、Fukuda M、Hadano S.
    • Organizer
      The 30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07832
  • [Presentation] A microdevice-based method for quantifying endolysosomal and mitochondrial axonal transport in neurons derived from a mouse model of ALS.2019

    • Author(s)
      Otomo, A., Kushida, T., Ishida, T., Araki, R., Sato, K., Mitsui, S., Ono, S., Kimura, H., and Hadano, S.
    • Organizer
      30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 神経終末におけるALS2 は、特異的な高次構造を形成する2019

    • Author(s)
      佐藤海、鈴木(宇都宮)恭子、島倉健人、大友麻子、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2タンパク質及び新規結合因子Rab17の分子機能解析2019

    • Author(s)
      小野鈴花、大友麻子、福田光則、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALSマウスモデル由来初代神経培養細胞のマイクロデバイスを用いた定量的軸索輸送解析2019

    • Author(s)
      大友麻子、串田隆志、石田智之、荒木良介、三井駿、小野鈴花、佐藤海、木村啓志、秦野伸二
    • Organizer
      Neuro2019
    • Data Source
      KAKENHI-PROJECT-19K07832
  • [Presentation] 神経系特異的SQSTM1の欠損はALSマウスモデルの発症を早期化させる2019

    • Author(s)
      三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
    • Organizer
      第42回日本神経科学大会/第62回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] 神経系特異的SQSTM1の欠損はALSマウスモデルの発症を早期化させる2019

    • Author(s)
      三井駿、石山政仁、島倉健人、佐藤海、小野鈴花、大友麻子、石井哲郎、柳川徹、青木正志、秦野伸二
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] マイクロデバイスによるALSマウスモデル由来初代神経培養細胞の定量的軸索輸送解析2019

    • Author(s)
      大友麻子、串田隆志、石田智之、荒木良介、三井駿、佐藤海、小野鈴花、木村啓志、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2はRac1活性依存的に低分子量Gタンパク質Rab17の細胞内局在を調節する2019

    • Author(s)
      小野鈴花、村越秀治、佐藤海、三井駿、大友麻子、福田光則、秦野伸二
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2 along with a novel ALS2 interacting protein Rab30 regulates morphological integrity and functions of the Golgi apparatus.2019

    • Author(s)
      Otomo, A., Onodera, W., Matsui, K., Sato, K., Mitsui, S., Ono, S., Fukuda, M., and Hadano, S.
    • Organizer
      30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] ALS2のリン酸化修飾がエンドゾーム動態に及ぼす影響2019

    • Author(s)
      島倉健人、佐藤海、大友麻子、秦野伸二
    • Organizer
      東海大学マイクロ・ナノ啓発会【Tμne】第11回学術講演会
    • Data Source
      KAKENHI-PROJECT-19H03551
  • [Presentation] Microdevice-based method for quantifying endolysosomal and mitochondrial axonal transport in neurons derived from a mouse model of ALS2019

    • Author(s)
      Otomo A、Kushida T、 Ishida T、Araki R、Sato K、Mitsui S、Ono S、 Kimura H、 Hadano S.
    • Organizer
      The 30th International Symposium on ALS/MND
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07832
  • [Presentation] Dichotomous effect of systemic overexpression of SQSTM1 on disease onset and post-onset survival in SOD1H46R mice.2017

    • Author(s)
      Mitsui, S., Otomo, A., Nozaki, M., Ono, S., Sato, K., Shirakawa, R., Adachi, H., Aoki, M., Sobue, G., Shang, H. -F. and Hadano, S.
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2017-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] The ALS2-interacting protein Rab30 is a possible regulator for vesicular trafficking between early endosome and the Golgi apparatus.2017

    • Author(s)
      Otomo, A., Matsui, K., Onodera, W., Sugiyama, J., Ishida, T., Sato, K., Mitsui, S., Shirakawa, R., Nozaki, M., Ono, S., Fukuda, M., and Hadano, S.
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2017-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] 軸索輸送現象の定量評価に向けた開放型マイクロデバイスの開発および評価2017

    • Author(s)
      横山奨,串田隆志,石田智之,大友麻子,秦野伸二,木村啓志
    • Organizer
      シンポジウム「細胞アッセイ技術の現状と将来」、細胞アッセイ研究会
    • Place of Presentation
      東京大学生産技術研究所コンベンションホール(東京都・目黒区)
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] 新規ALS2結合候補分子Rab30の発現及び細胞内動態解析2016

    • Author(s)
      松井香奈、小野寺和歌奈、大友麻子、福田光則、秦野伸二
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] マイクロ流体デバイスを用いたALS疾患モデルの解析2016

    • Author(s)
      石田智之、荒木良介、大友麻子、横山奨、串田隆志、杉山純也、秦野伸二、木村啓志
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Systemic overexpression of SQSTM1 accelerates age of disease onset and reduces survival in SOD1H46R mice.2016

    • Author(s)
      Mitsui, S., Otomo, A., Nozaki, M., Ono, S., Sato, K., Shirakawa, R., Adachi, H., Aoki, M., Sobue, G., Shang, H. -F., and Hadano, S.
    • Organizer
      27th International Symposium on ALS/MND
    • Place of Presentation
      Dublin (Republic of Ireland)
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] SQSTM1の全身性高発現は変異SOD1発現ALSマウスモデルの発症を早める2016

    • Author(s)
      三井駿、大友麻子、野崎昌久、小野鈴花、佐藤海、白川涼平、足立弘明、青木正志、祖父江元、Shang, H. -F.、秦野伸二
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Analysis of axonal transport in cultured neurons from ALS model mouse by using the microfluidic cell culture system.2016

    • Author(s)
      Otomo, A., Araki, R., Yokoyama, S., Wada, J., Hadano, S., and Kimura, H.
    • Organizer
      第39回日本神経科学大会(Neuroscience2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] マイクロ流体デバイスを用いた神経疾患モデルの確立.2016

    • Author(s)
      荒木良介、大友麻子、横山奨、和田純希、秦野伸二、木村啓志
    • Organizer
      細胞アッセイ研究会
    • Place of Presentation
      東京大学生産技術研究所コンベンションホール(東京都、文京区)
    • Year and Date
      2016-01-19
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] A novel teaching approach based on a DNA experiment lesson in high school biology laboratory class: Scientific inquiry by visualization of DNA sequence conservation and diversity and a developmental lesson to understand genetic diagnosis.2016

    • Author(s)
      Inoue, Y., Otomo, A., Takahashi, K., Moriya, H., Ohnuki, Y., Izumi, S., Miyachi, H., and Hadano, S.
    • Organizer
      2016 International Conference of East-Asian Association for Science Education (EASE2016 Tokyo)
    • Place of Presentation
      東京理科大学(東京都・新宿区)
    • Year and Date
      2016-08-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2/Alsin in recycling endosomes.2016

    • Author(s)
      Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
    • Organizer
      第39回日本神経科学大会(Neuroscience2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2/Alsin in recycling endosomes.2016

    • Author(s)
      Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Loss of SQSTM1/p62 but not NFE2L2/Nrf2 exacerbates motor neuron degeneration in a mutant SOD1-expressing mouse ALS model.2016

    • Author(s)
      Hadano, S., Mitsui, S., Otomo, A., Sato, K., Ono, S., Chen, X. P., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
    • Organizer
      15th Asian and Oceanian Congress of Neurology
    • Place of Presentation
      Kuala Lumpur (Malaysia)
    • Year and Date
      2016-08-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Loss of SQSTM1/p62 but not NFE2L2/Nrf2 exacerbates motor neuron degeneration in a mutant SOD1-expressing mouse ALS model.2016

    • Author(s)
      Hadano, S., Mitsui, S., Otomo, A., Sato, K., Ono, S., Chen, X. P., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
    • Organizer
      15th Asian and Oceanian Congress of Neurology
    • Place of Presentation
      Kuala Lumpur Convention Centre (Kuala Lumpur, Malaysia)
    • Year and Date
      2016-08-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] 明暗条件がマウスの行動に及ぼす影響2016

    • Author(s)
      内藤佳津子、上條あけみ、岩尾佳代子、秦野伸二
    • Organizer
      第50回日本実験動物技術者協会総会
    • Place of Presentation
      ウェスタ川越(埼玉県・川越市)
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] ALS2疾患原因変異体の高次構造および細胞内局在の変化はALS2関連運動ニューロン疾患の発症要因である2016

    • Author(s)
      佐藤海、鈴木-宇都宮恭子、平塚結衣、三井駿、小野鈴花、大友麻子、秦野伸二
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Alterations of oligomeric states and subcellular localization of ALS2 mutants underlie the pathogenesis of ALS2-linked motor neuron diseases.2016

    • Author(s)
      Sato, K., Suzuki-Utsunomiya, K., Hiratsuka, Y., Mitsui, S., Ono, S., Otomo, A., and Hadano, S.
    • Organizer
      27th International Symposium on ALS/MND
    • Place of Presentation
      Dublin (Republic of Ireland)
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] 神経変性疾患の発症機序解明に向けた新たな展開2016

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第12回研修会
    • Place of Presentation
      東海大学医学部(神奈川県・伊勢原市)
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Analysis of axonal transport in cultured neurons from ALS model mouse by using the microfluidic cell culture system.2016

    • Author(s)
      Otomo, A., Araki, R., Yokoyama, S., Wada, J., Hadano, S., and Kimura, H.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Molecular pathogenesis of ALS: Dysregulation of membrane trafficking and proteostasis.2016

    • Author(s)
      Hadano, S.
    • Organizer
      Annual conference 2016: Movement Disorders and Motor Neuron Disease, Society of Neurology in Sichuan Province
    • Place of Presentation
      Chengdu (China)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] ALS患者由来SQSTM1/p62変異体の神経細胞における局在と機能の解析2016

    • Author(s)
      白川涼平、濱祐太郎、大友麻子、Shang, H. -F.、秦野伸二
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Analysis of axonal transport in cultured neurons derived from an ALS mouse model by using the microfluidic cell culture system.2016

    • Author(s)
      Otomo, A., Araki, R., Ishida, T., Shirakawa, R., Mitsui, S., Ono, S., Sato, K., Yokoyama, S., Kimura, H., and Hadano, S.
    • Organizer
      27th International Symposium on ALS/MND
    • Place of Presentation
      Dublin (Republic of Ireland)
    • Year and Date
      2016-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Development of novel device with high-throughout axonal transport quantification.2016

    • Author(s)
      Yokoyama, S., Wada, J., Kushida, T., Araki, R., Ishida, T., Otomo, A., Hadano, S., and Kimura, H.
    • Organizer
      The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Dublin (Republic of Ireland)
    • Year and Date
      2016-10-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Neurological diseases: Recent advances in studies on genes and their functions.2015

    • Author(s)
      Hadano, S.
    • Organizer
      2015 Tianfu International Stroke Conference
    • Place of Presentation
      Holiday Inn Chengdu Century City- West Tower (Chengdu, China)
    • Year and Date
      2015-05-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Pathogenic mutations in ALS2 alter the oligomeric states of the ALS2 complex and its subcellular localization.2015

    • Author(s)
      Sato, K., Hiratsuka, Y., Suzuki-Utsunomiya, K., Otomo, A., and Hadano, S.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] SQSTM1/p62及びその変異体の神経細胞における局在解析.2015

    • Author(s)
      白川涼平、濱祐太郎、大友麻子、秦野伸二
    • Organizer
      BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Motor neuron diseases: Recent advances in studies on genes and their functions.2015

    • Author(s)
      Hadano, S.
    • Organizer
      Society of Neurology in Sichuan Province
    • Place of Presentation
      Holiday Inn Chengdu Century City- West Tower (Chengdu, China)
    • Year and Date
      2015-05-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] SOD1H46R発現ALSマウスモデルの運動ニューロン変性はNrf2ではなく、p62/SQSTM1の機能喪失により悪化する.2015

    • Author(s)
      三井駿、久保瑞希、潘雷、大友麻子、小池正人、内山安男、青木正志、山本雅之、石井哲郎、柳川徹、Hui-Fang Shang、吉井文均、秦野伸二
    • Organizer
      BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] ALS2疾患原因変異体はALS2複合体構造や細胞内局在を変化させる.2015

    • Author(s)
      佐藤海、平塚結衣、大友麻子、秦野伸二
    • Organizer
      BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Loss of p62/SQSTM1 but not Nrf2 accelerates motor neuron degeneration in SOD1H46R transgenic mice.2015

    • Author(s)
      Mitsui, S., Kubo, M., Pan, L., Otomo, A., Koike, M., Uchiyama, Y., Aoki, M., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, H. -F., Yoshii, F., and Hadano, S.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-07-28
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] マイクロ流体デバイスを用いたALS疾患モデルの確立.2015

    • Author(s)
      荒木良介、大友麻子、横山奨、和田純希、秦野伸二、木村啓志
    • Organizer
      BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] The novel ALS2-interacting small G protein Rab17 colocalizes with ALS2 in recycling endosomes.2015

    • Author(s)
      Ono, S., Otomo, A., Onodera, W., Sato, K., Mitsui, S., Fukuda, M., and Hadano, S.
    • Organizer
      26th International Symposium on ALS/MND
    • Place of Presentation
      JM Marriott Orlando Grande Lakes (Orlando, U.S.A.)
    • Year and Date
      2015-12-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] ALS2及び新規結合低分子量Gタンパク質Rab17はリサイクリングエンドソームに局在する.2015

    • Author(s)
      小野鈴花、大友麻子、福田光則、秦野伸二
    • Organizer
      BMB2015・第38回日本分子生物学会年会・第88回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] オートファジー関連因子p62/SQSTM1 の機能喪失はALS マウスモデルの疾患症状を悪化させる2014

    • Author(s)
      秦野伸二, 潘雷, 大友麻子, 阿部幸一郎, 小池正人, 内山安男, 青木正志, 吉井文均, 石井哲郎, 柳川徹
    • Organizer
      日本実験動物科学技術さっぽろ2014 : 第61回日本実験動物学会総会/第48回日本実験動物技術者協会総会
    • Place of Presentation
      札幌(講演要旨集, p190(O088-S))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響2014

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第17回公開研究報告会
    • Place of Presentation
      伊勢原
    • Year and Date
      2014-03-28
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALSモデルマウスにおけるIP6K2の病態への関連性について(第2報)2013

    • Author(s)
      森谷祐介、永田栄一郎、潘雷、佐藤忠之、小川温子、秦野伸二、瀧澤俊也
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Molecular pathogenesis of ALS/MNDs : Dysfunction of autophagy-endolysosomal system2013

    • Author(s)
      Hadano S
    • Organizer
      Invited lecture at Beijing University
    • Place of Presentation
      Beijing University, Beijing, China
    • Year and Date
      2013-03-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1 mutations in sporadic Chinese patients with amyotrophic lateral sclerosis.2013

    • Author(s)
      Chen, Y., Chen, X., Huang, R., Zheng, Z., Wei, Q., Guo, X., Pan, L., Hadano, S., and Shang, H.
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] SQSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響2013

    • Author(s)
      秦野伸二
    • Organizer
      第7回オートファジー研究会
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Rab5 activator ALS2 and RabGEF1, regulate amphisome formation and degradation2013

    • Author(s)
      Otomo A, Pan L, Ogawa H, Hiratsuka Y, Hadano S
    • Organizer
      Neuro2013 : 第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都(P1-2-31)
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1 mutations in sporadic Chinese patients with amyotrophic lateral sclerosis2013

    • Author(s)
      Chen Y, Chen X, Huang R, Zheng Z, Wei Q, Guo X, Pan L, Hadano S, Shang H
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy(SW06)
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] (2013)ALSモデルマウスにおけるIP6K2 の病態への関連性について(第2報)2013

    • Author(s)
      森谷祐介, 永田栄一郎, 潘雷, 佐藤忠之, 小川温子, 秦野伸二, 瀧澤俊也
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Inositol hexakisphosphate kinase 2 is one of the candidate molecules as diagnostic marker for amyotrophic lateral sclerosis2013

    • Author(s)
      Nagata E, Moriya Y, Fujii N, Kohara S, Satoh T, Takao M, Pan L, Ogawa H, Hadano S, Mihara B, Takizawa S
    • Organizer
      Neuro2013 : 第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都(O2-9-1-1)
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of p62/SQSTM1 exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model.2013

    • Author(s)
      Pan, L., Otomo, A., Abe, K., Ogawa, H., Chiba, T., Koike, M., Uchiyama, Y., Aoki, M., Yoshii, F., Ishii, T., Yanagawa, T., and Hadano, S.
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Animal experiments in Tokai University : Center of Genetic Engineering for Human Diseases (CGHED)2013

    • Author(s)
      Hadano S
    • Organizer
      Invited lecture at Dalian Institute of Chemical Physics
    • Place of Presentation
      Dalian, Liaoning, China
    • Year and Date
      2013-03-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALSモデルマウスにおけるIP6K2の病態への関連性について(第2報)2013

    • Author(s)
      森谷祐介、永田栄一郎、潘雷、佐藤忠之、小川温子、秦野伸二、瀧澤俊也
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] 細胞内エンドソーム動態と神経変性. 厚生労働科学研究費補助金難治性疾患等克服研究事業神経変性疾患に関する調査研究班,「病態に根ざしたALS の新規治療法開発」分科班2013

    • Author(s)
      秦野伸二
    • Organizer
      平成25年度ワークショップ, プログラム
    • Place of Presentation
      東京(要旨集, p3)
    • Year and Date
      2013-09-27
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 低分子量Gタンパク質Rab5の活性化因子、ALS2とRabGEF1は、EEA1-LC3陽性小胞の成熟と分解効率を調節する2013

    • Author(s)
      大友麻子、潘雷、小川温子、平塚結衣、秦野伸二
    • Organizer
      Neuro2013:第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] 低分子量Gタンパク質Rab5の活性化因子、ALS2とRabGEF1は、EEA1-LC3陽性小胞の成熟と分解効率を調節する2013

    • Author(s)
      大友麻子、潘雷、小川温子、平塚結衣、秦野伸二
    • Organizer
      Neuro2013:第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 筋萎縮性側索硬化症におけるイノシトール6リン酸キナーゼ2の役割2013

    • Author(s)
      永田栄一郎、森谷祐介、藤井奈津子、小原さおり、佐藤忠之、高尾昌樹、潘雷、小川温子、秦野伸二、三原盤、瀧澤俊也
    • Organizer
      Neuro2013:第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1 mutations in sporadic Chinese patients with amyotrophic lateral sclerosis.2013

    • Author(s)
      Chen, Y., Chen, X., Huang, R., Zheng, Z., Wei, Q., Guo, X., Pan, L., Hadano, S., and Shang, H.
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] マウスモデルを用いたALS疾患症状の調節要因に関する研究.2013

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第4回シンポジウム
    • Place of Presentation
      霞ヶ関/東京
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Loss of p62/SQSTM1 exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model2013

    • Author(s)
      Pan L, Otomo A, Abe K, Ogawa H, Chiba T, Koike M, Uchiyama Y, Aoki M, Yoshii F, Ishii T, Yanagawa T, Hadano S
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy(Amyotroph. Lateral Scler. Frontotempo. Degen. 14 (suppl. 1), 180-181 (P217))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] マウスモデルを用いたALS 疾患症状の調節要因に関する研究2013

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第4回シンポジウム・私立大学戦略的研究基盤形成支援事業進捗報告会
    • Place of Presentation
      霞ヶ関/東京
    • Year and Date
      2013-02-23
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響2013

    • Author(s)
      秦野伸二
    • Organizer
      第7回オートファジー研究会
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] マウスモデルを用いたALS疾患症状の調節要因に関する研究.2013

    • Author(s)
      秦野伸二
    • Organizer
      総合医学研究所第4回シンポジウム
    • Place of Presentation
      霞ヶ関/東京
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 筋萎縮性側索硬化症におけるイノシトール6リン酸キナーゼ2の役割2013

    • Author(s)
      永田栄一郎、森谷祐介、藤井奈津子、小原さおり、佐藤忠之、高尾昌樹、潘雷、小川温子、秦野伸二、三原盤、瀧澤俊也
    • Organizer
      Neuro2013:第36回日本神経科学会大会/第56回日本神経化学会大会/第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Loss of p62/SQSTM1 exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model.2013

    • Author(s)
      Pan, L., Otomo, A., Abe, K., Ogawa, H., Chiba, T., Koike, M., Uchiyama, Y., Aoki, M., Yoshii, F., Ishii, T., Yanagawa, T., and Hadano, S.
    • Organizer
      24th International Symposium on ALS/MND
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SQSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響2013

    • Author(s)
      秦野伸二
    • Organizer
      第7回オートファジー研究会兼新学術領域「オートファジー」第1回班会議
    • Place of Presentation
      掛川
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Molecular pathogenesis of ALS/MNDs : Dysfunction of autophagy-endolysosomal system2013

    • Author(s)
      Hadano S
    • Organizer
      Fujian Conference of Neurology on Neurodegenerative Diseases
    • Place of Presentation
      Fujian Medical University, Fuzhou, China
    • Year and Date
      2013-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Bromocriptine retards disease progression in an ALS mouse model via suppression of glial inflammation2012

    • Author(s)
      Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Hadano S, Yohii F, Ikeda J. E
    • Organizer
      23rd International Symposium on ALS/MND
    • Place of Presentation
      Chicago, Illinois, U.S.A.(Amyotroph. Lateral Scler. 13 (suppl. 1), 63 (P9))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Dysregulation of the autophagy-endolysosomal system in ALS and FTD.2012

    • Author(s)
      Hadano, S.
    • Organizer
      The 15th National Conference of Neurology
    • Place of Presentation
      Guangzhou, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Dysregulation of the autophagy-endolysosomal system in motor neuron diseases.2012

    • Author(s)
      Hadano, S.
    • Organizer
      BIT’s 3rd Annual World Congress on NeuroTalk-2012
    • Place of Presentation
      Beijing, China
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Dysregulation of the autophagy-endolysosomal system in motor neuron diseases.2012

    • Author(s)
      Hadano, S.
    • Organizer
      BIT’s 3rd Annual World Congress on NeuroTalk-2012
    • Place of Presentation
      Beijing, China
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 家族性ALS原因遺伝子産物ALS2の機能喪失がオートファジー系に及ぼす影響.2012

    • Author(s)
      秦野伸二
    • Organizer
      第11回生体機能研究会
    • Place of Presentation
      箱根/神奈川
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R> transgenic mouse model of ALS2012

    • Author(s)
      Hadano, S
    • Organizer
      Invited lecture at West China Hospital/Sichuan University
    • Place of Presentation
      四川大学、成都、中国
    • Year and Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 新しいがん治療法および歯周病治療法の提言と装置開発II2012

    • Author(s)
      伊東丈夫, 太田嘉英, 秦野伸二
    • Organizer
      東海大学産学連携フェア2012
    • Place of Presentation
      東海大学湘南キャンパス/平塚
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Different human copper-zinc superoxide dismutase mutants, SOD1^<G93A> and SOD1^<H46R>, exert distinct harmful effects on gross phenotype in mice2012

    • Author(s)
      Pan L, Yoshii Y, Otomo A, Ogawa H, Iwasaki Y, Shang H. F and Hadano S
    • Organizer
      23rd International Symposium on ALS/MND
    • Place of Presentation
      Chicago, Illinois, U.S.A.(Amyotroph. Lateral Scler. 13 (suppl. 1), 36 (C60))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 低分子量G タンパク質Rab5 の活性化因子,ALS2 とRabGEF1 は, EEA1-LC3 要請小胞の形成と成熟を調節する2012

    • Author(s)
      大友麻子, 潘雷, 小川温子, 平塚結衣, 秦野伸二
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(3ST-067 (3P-0087))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Post-onset administration of bromocriptine sustains motor functions and retards disease progression in a mouse model of amyotrophic lateral sclerosis via suppression of glial inflammation.2012

    • Author(s)
      Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Hadano S, Yoshii F and Ikeda J. E
    • Organizer
      14th Annual Meeting of American Society for Experimental Neurotherapeutics
    • Place of Presentation
      Washington, DC, U.S.A(Program Book, p3 (Poster Abstract #14))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1H46R transgenic mouse model of ALS2012

    • Author(s)
      Hadano S
    • Organizer
      Invited lecture at West China Hospital/Sichuan University
    • Place of Presentation
      Chengdu, Sichuan, China
    • Year and Date
      2012-02-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 家族性ALS原因遺伝子産物ALS2の機能喪失がオートファジー系に及ぼす影響.2012

    • Author(s)
      秦野伸二
    • Organizer
      第11回生体機能研究会
    • Place of Presentation
      箱根/神奈川
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Role of inositol hexakisphosphate kinase 2 in a mouse model for amyotrophic lateral sclerosis2012

    • Author(s)
      Moriya, Y., Nagata, E., Pan, L Sato T, Ogawa H, Hadano S, Takizawa S
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, Louisiana, U.S.A(Program#/Poster#: 242.06/E24)
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ysregulation of the autophagy-endolysosomal system in ALS and FTD.2012

    • Author(s)
      Hadano, S.
    • Organizer
      The 15th National Conference of Neurology
    • Place of Presentation
      Guangzhou, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Advances in the studies on the molecular pathogenesis of amyotrophic lateral sclerosis/motor neuron diseases (ALS/MNDs)2011

    • Author(s)
      Hadano, S
    • Organizer
      Invited lecture at West China Hospital/Sichuan University
    • Place of Presentation
      四川大学、成都、中国(招待講演)
    • Year and Date
      2011-07-01
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R> transgenic mouse model of ALS2011

    • Author(s)
      Hadano, S
    • Organizer
      第54回日本神経化学会(石川)大会
    • Place of Presentation
      瑠璃光、加賀市
    • Year and Date
      2011-09-26
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Advances in the studies on the molecular pathogenesis of amyotrophic lateral sclerosis/motor neuron diseases (ALS/MNDs)2011

    • Author(s)
      Hadano S
    • Organizer
      Invited lecture at West China Hospital/Sichuan University
    • Place of Presentation
      Chengdu, Sichuan, China
    • Year and Date
      2011-07-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] A small molecular compound CPN-9 selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway2011

    • Author(s)
      Kanno T, Tanaka K, Yanagisawa Y, Yasutake K, Hadano S, Hirayama N, Ikeda J. E.
    • Organizer
      22nd International Symposium on ALS/MND
    • Place of Presentation
      Sydney, NSW, Australia(Amyotroph. Lateral Scler. 12 (suppl. 1), 136-137 (P151))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] SOD1H46R 遺伝子組み換えALS マウスモデルにおいてグリア線維性酸性蛋白の欠損は疾患をわずかに進行させる2011

    • Author(s)
      吉井康裕, 大友麻子, Lei Pan, 大塚正人, 川邊清一, 池田憲, 岩崎泰雄, 池田穰衛, 秦野伸二
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(p381(O6-209))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 筋萎縮性側索硬化症の新規治療薬の開発2011

    • Author(s)
      池田穰衛, 田中一則, 菅野拓也, 柳沢佳子, 安武かおり, 秦野伸二, 吉井文均
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(p382(O6-213))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R> transgenic mouse model of ALS(SOD1^<H46R> 遺伝子組み換えALS マウスモデルにおいてグリア線維性酸性蛋白の欠損は疾患をわずかに進行させる)2011

    • Author(s)
      Hadano S, Yoshii Y, Otomo A, Pan L, Ohtsuka M, Iwasaki Y
    • Organizer
      第54回日本神経化学会(石川)大会抄録号
    • Place of Presentation
      加賀/石川(神経化学50(2-3), 159 (O2-2))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Defective relocalization of ALS2/alsin to Rac1-induced macropinosomes accounts for loss of its cellular function and leads to disturbed amphisome formation2011

    • Author(s)
      Otomo A, Kunita R, Suzuki-Utsunomiya K, Ikeda J. E, Hadano S
    • Organizer
      22nd International Symposium on ALS/MND
    • Place of Presentation
      Sydney, NSW, Australia(Amyotroph. Lateral Scler. 12 (suppl. 1), 134 (P146))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 神経細胞におけるタンパク質分解系の統合的分子制御機構の解明2011

    • Author(s)
      秦野伸二
    • Organizer
      東海大学研究フォーラム2011
    • Place of Presentation
      東海大学湘南校舎、平塚市
    • Year and Date
      2011-12-08
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 神経変性疾患におけるグリア細胞の役割2011

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第7回研修会
    • Place of Presentation
      湯河原/ 神奈川
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R> transgenic mouse model of ALS(SOD1^<H46R>遺伝子組み換えALSマウスモデルにおいてグリア線維性酸性蛋白の欠損は疾患をわずかに進行させる)2011

    • Author(s)
      Hadano S, Yoshii Y, Otomo A, Pan L, Ohtsuka M, Iwasaki Y
    • Organizer
      第54回日本神経化学会(石川)大会抄録号
    • Place of Presentation
      加賀/石川(神経化学50(2-3),159 (O2-2))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALS発症の分子機構.-ALS2の分子機能と細胞内タンパク質分解系との関連-2011

    • Author(s)
      秦野伸二
    • Organizer
      第2回東海大学テニュアトラック制度シンポジウム
    • Place of Presentation
      東海大学交友会館、霞ヶ関ビル、千代田区(招待講演)
    • Year and Date
      2011-12-19
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 神経変性疾患におけるグリア細胞の役割2011

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第7回研修会
    • Place of Presentation
      湯河原/神奈川
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Advances in the studies on the molecular pathogenesis of amyotrophic lateral sclerosis/motor neuron diseases (ALS/MNDs)2011

    • Author(s)
      Hadano, S
    • Organizer
      Invited lecture at Dalian Institute of Chemical Physics
    • Place of Presentation
      中科院大連化学物理研究所、大連、中国(招待講演)
    • Year and Date
      2011-06-30
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 神経変性疾患におけるグリア細胞の役割2011

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第7回研修会
    • Place of Presentation
      山水楼、湯河原市
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 神経細胞におけるタンパク質分解系の統合的分子制御機構の解明2011

    • Author(s)
      秦野伸二, 潘雷, 大塚正人, 大友麻子
    • Organizer
      東海大学研究フォーラム2011
    • Place of Presentation
      東海大学湘南キャンパス/平塚(東海大学研究シーズ・研究報告集2012,p32)
    • Year and Date
      2011-12-08
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1^<H46R>-expressing mouse ALS model2011

    • Author(s)
      Yoshii Y, Otomo A, Pan L, Ohtsuka M, Iwasaki Y, Hadano S
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(2T11pI-2/2P-0869)
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Distinctive high-molecular weight oligomeric complexes of ALS2/alsin are enriched in the brain synaptosomal compartments2011

    • Author(s)
      Suzuki-Utsunomiya K, Otomo A, Kunita R, Ikeda J. E, Hadano S
    • Organizer
      22nd International Symposium on ALS/MND
    • Place of Presentation
      Sydney, NSW, Australia(Amyotroph. Lateral Scler. 12 (suppl. 1), 134-135 (P147))
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALS 発症の分子機構. -ALS2 の分子機能と細胞内タンパク質分解系との関連2011

    • Author(s)
      秦野伸二
    • Organizer
      第2回東海大学テニュアトラック制度シンポジウム,東海大学創造科学技術研究機構
    • Place of Presentation
      霞ヶ関/ 東京
    • Year and Date
      2011-12-19
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Advances in the studies on the molecular pathogenesis of amyotrophic lateral sclerosis/motor neuron diseases (ALS/MNDs)2011

    • Author(s)
      Hadano S
    • Organizer
      Invited lecture at Dalian Institute of Chemical Physics
    • Place of Presentation
      Dalian, Liaoning, China
    • Year and Date
      2011-06-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALS2/alsin, a Rab5 guanine nucleotide exchange factor, acts as a regulator for autophagosomalendolysosomal protein degradation. Keystone Symposia, Cell Death Pathway2010

    • Author(s)
      Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, Ikeda JE
    • Organizer
      Apoptosis, Autophagy and Necrosis (X3)
    • Place of Presentation
      Vancouver, Canada
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] 神経細胞におけるタンパク質分解系の統合的分子制御機構の解明2010

    • Author(s)
      秦野伸二
    • Organizer
      東海大学研究フォーラム2010
    • Place of Presentation
      平塚市
    • Year and Date
      2010-03-05
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] ALS2/alsin, a Rab5 guanine nucleotide exchange factor, acts as a regulator for autophagosomal-endolysosomal protein degradation.2010

    • Author(s)
      Hadano, S.
    • Organizer
      Keystone Symposia, Cell Death Pathway : Apoptosis, Autophagy and Necrosis
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-03-14
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of Rac1-induced macropinosomal and endosomal localization of ALS2 underlies the pathogenesis for motor neuron diseases caused by missense mutations in the ALS2 gene2009

    • Author(s)
      Otomo A, Kunita R, Suzuki-Utsunomiya K, Ikeda JE, Hadano S
    • Organizer
      20th International Symposium on ALS/MND
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Generation and characterization of congenic lines of mutant SOD1 transgenic and Als2 knockout mice.2009

    • Author(s)
      Hadano, S.
    • Organizer
      20th International Symposium on ALS/MND
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] 筋萎縮性側索硬化症/運動ニューロン疾患研究の新展開.-オートファジーとエンドゾーム動態との関連について-2009

    • Author(s)
      秦野伸二
    • Organizer
      Cell Biology Summer Meeting 2009
    • Place of Presentation
      つくば市
    • Year and Date
      2009-07-12
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] 筋萎縮性側索硬化症/運動ニューロン疾患研究の新展開. -オートファジーとエンドゾーム動態との関連について-2009

    • Author(s)
      秦野伸二
    • Organizer
      Cell Biology Summer Meeting 2009 (CBSM2009)
    • Place of Presentation
      つくば
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Generation and characterization of congenic lines of mutant SOD1 transgenic and Als2 knockout mice2009

    • Author(s)
      Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Yoshii Y, Aoki M, Itoyama Y, Iwasaki Y, Ikeda JE
    • Organizer
      20th International Symposium on ALS/MND
    • Place of Presentation
      Berlin, Germany
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of ALS2 exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model.2008

    • Author(s)
      Hadano, S.
    • Organizer
      日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of ALS2/alsin exacerbates motor dysfunction and axonal damage in SOD1H46R transgenic mice2008

    • Author(s)
      Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Onoe K, Osuga H, Aoki M, Itoyama Y, Ikeda JE
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of ALS2/alsin exacerbates motor dysfunction and axonal damage in SOD1^<H46R> transgenio mice.2008

    • Author(s)
      Hadano, S.
    • Organizer
      日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of Rac1- mediated macropinosomal recruitment of ALS2/alsin underlies the pathogenesis for motor neuron disease caused by missense mutations in the ALS2 gene. BMB20082008

    • Author(s)
      Otomo A, Kunita R, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会、合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] ALS2/alsin-deficient SOD1^<H46R> transgenic mice exhibit increased insoluble proteins in the spinal cord.2008

    • Author(s)
      Hadano, S.
    • Organizer
      19th International Symposium on ALS/MND
    • Place of Presentation
      Birmingham, UK
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] ALS2/alsin-deficient SOD1H46R transgenic mice exhibit increased insoluble proteins in the spinal cord2008

    • Author(s)
      Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Onoe K, Osuga H, Aoki M, Itoyama Y, Ikeda JE
    • Organizer
      19th International Symposium on ALS/MND
    • Place of Presentation
      Birmingham, U.K.
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated macropinocytosis2007

    • Author(s)
      Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
    • Organizer
      Human Genome Meeting 2007
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss ofALS2/alsin exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model2007

    • Author(s)
      Hadano, S., et. al.
    • Organizer
      18th International Symposium on ALS/MND
    • Place of Presentation
      Toronto/Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Loss of ALS2/alsin exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model2007

    • Author(s)
      Hadano, S.
    • Organizer
      18th International Symposium on ALS/MND
    • Place of Presentation
      Toronto/Ontario,Canada
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] The Rab5 activator ALS2/alsin acts as a novel Rac1 effector via Rac1-activated macropinocytosis2007

    • Author(s)
      Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
    • Organizer
      第50回日本神経化学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] ALS2/alsin is localized to endosomes in primary cultured hippocampal neurons and implicated in axon elongation2007

    • Author(s)
      Otomo A, Kunita R, Suzuki-Utsunomiya K, Mizumura H, Onoe K, Osuga H, Hadano S, Ikeda JE
    • Organizer
      Human Genome Meeting 2007
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-19500330
  • [Presentation] Loss of ALS2/alsin exacerbates motor dysfunction in a mutant SOD1-expressing mouse ALS model2007

    • Author(s)
      Hadano, S.
    • Organizer
      18th International Symposium on ALS/MND
    • Place of Presentation
      Toronto,Canada
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Mice deficient in ALS2 exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S.
    • Organizer
      A Genetics Society of America MEETING
    • Place of Presentation
      San Diego/U.S.A.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Mice deficient in ALS2 exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S., et. al.
    • Organizer
      A Genetics Society of America MEETING
    • Place of Presentation
      San Diego/USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Loss of ALS2 in mice produces age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S., et. al.
    • Organizer
      Japanese Society for Neurochemistry
    • Place of Presentation
      Nagoya/Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Loss of ALS2 in mice produces age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S.
    • Organizer
      日本神経化学会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Mice deficient in ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S., et. al.
    • Organizer
      The 20th IUBMB International Congress of Biochemistry and Molecular Biology and llth FAOBMB Congress
    • Place of Presentation
      Kyoto/Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Mice deficient in ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking2006

    • Author(s)
      Hadano, S.
    • Organizer
      IUBMB/FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] ALS2CL, a novel ALS2 interacting protein, modulates the ALS2-mediated endosomal dynamics2005

    • Author(s)
      Hadano, S., et. al.
    • Organizer
      16th International Symposium on ALS/MND
    • Place of Presentation
      Dublin/Ireland
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] ALS2CL,a novel ALS2 interacting protein,modulates the ALS2-mediated endosomal dynamics2005

    • Author(s)
      Hadano, S.
    • Organizer
      16th International Symposium on ALS/MND
    • Place of Presentation
      Dublin,Ireland
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17300121
  • [Presentation] Molecular pathogenesis of ALS/MNDs: Dysfunction of autophagy-endolysosomal system.

    • Author(s)
      Hadano, S.
    • Organizer
      Fujian Conference of Neurology on Neurodegenerative Diseases
    • Place of Presentation
      Fuzhou, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] 細胞内エンドソーム動態と神経変性

    • Author(s)
      秦野伸二
    • Organizer
      厚生労働科学研究費補助金難治性疾患等克服研究事業神経変性疾患に関する調査研究班、「病態に根ざしたALSの新規治療法開発」分科班、平成25年度ワークショップ
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] オートファジー関連因子p62/SQSTM1の機能喪失はALSマウスモデルの疾患症状を悪化させる

    • Author(s)
      秦野伸二、潘雷、大友麻子、阿部幸一郎、小池正人、内山安男、青木正志、吉井文均、石井哲郎、柳川徹
    • Organizer
      日本実験動物科学技術さっぽろ2014:第61回日本実験動物学会総会/第48回日本実験動物技術者協会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] オートファジー動態の可視化を目的とした新規トランスジェニックマウスの作出

    • Author(s)
      秦野伸二、王婷、田中政之、林英樹、荻原早苗、岡田千沙、伊藤誠敏、福西菜穂子、飯田裕美、中村彩花、大友麻子、大塚正人
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Loss of p62/SQSTM1, an autophagy substrate, aggravates motor dysfunction in a SOD1H46R-expressing mouse ALS model.

    • Author(s)
      Hadano, S., Pan, L., Otomo, A., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] オートファジー関連因子p62/SQSTM1の機能喪失はALSマウスモデルの疾患症状を悪化させる

    • Author(s)
      秦野伸二、潘雷、大友麻子、阿部幸一郎、小池正人、内山安男、青木正志、吉井文均、石井哲郎、柳川徹
    • Organizer
      第61回日本実験動物学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-15 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] 筋萎縮性側索硬化症原因遺伝子産物ALS2に結合する新規調節因子Rab30の機能解析

    • Author(s)
      小野寺和歌奈、大友麻子、福田光則、秦野伸二
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Molecular pathogenesis of ALS/MNDs: Dysfunction of autophagy-endolysosomal system.

    • Author(s)
      Hadano, S.
    • Organizer
      Fujian Conference of Neurology on Neurodegenerative Diseases
    • Place of Presentation
      Fuzhou, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] SQSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第17回公開研究報告会
    • Place of Presentation
      伊勢原
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] Generation and characterization of a novel transgenic mouse model for monitoring the autophagy-endolysosomal system.

    • Author(s)
      Hadano, S., Wang, T., Tanaka, M., Hayashi, H., Ogiwara, S., Okada, C., Itoh, M., Fukunishi, N., Iida, Y., Nakamura, A., Otomo, A., and Ohtsuka, M.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] Loss of p62/SQSTM1, an autophagy substrate, aggravates motor dysfunction in a SOD1H46R-expressing mouse ALS model.

    • Author(s)
      Hadano, S., Pan, L., Otomo, A., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Ishii, T., Yanagawa, T., Shang, H. -F., and Yoshii, F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] p62/SQSTM1 deficiency accelerates motor neuron degeneration in SOD1H46R transgenic mice.

    • Author(s)
      Pan, L., Otomo, A., Koike, M., Uchiyama, Y., Aoki, M., Abe, K., Ishii, T., Yanagawa, T., Shang, H. -F., Yoshii, F., and Hadano, S.
    • Organizer
      25th International Symposium on ALS/MND
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] p62/SQSTM1 deficiency accelerates motor neuron degeneration in SOD1H46R transgenic mice.

    • Author(s)
      Pan, L., Otomo, A., Koike, M., Uchiyama, Y., Aoki, M., Abe, K., Ishii, T., Yanagawa, T., Shang, H. -F., Yoshii, F., and Hadano, S.
    • Organizer
      25th International Symposium on ALS/MND
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2014-12-05 – 2014-12-07
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Identification and characterization of a novel ALS2 interacting protein Rab30.

    • Author(s)
      Onodera, W., Otomo, A., Fukuda, M., and Hadano, S.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] QSTM1遺伝子変異が筋萎縮性側索硬化症(ALS)の発症に及ぼす影響

    • Author(s)
      秦野伸二
    • Organizer
      東海大学総合医学研究所第17回公開研究報告会
    • Place of Presentation
      伊勢原
    • Data Source
      KAKENHI-PROJECT-24650189
  • [Presentation] Subcellular distribution of ALS2 and the novel ALS2-interacting small G protein Rab17.

    • Author(s)
      Ono, S., Otomo, A., Fukuda, M., and Hadano, S.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26290018
  • [Presentation] 細胞内エンドソーム動態と神経変性

    • Author(s)
      秦野伸二
    • Organizer
      厚生労働科学研究費補助金難治性疾患等克服研究事業神経変性疾患に関する調査研究班、「病態に根ざしたALSの新規治療法開発」分科班、平成25年度ワークショップ
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300129
  • [Presentation] ALS2及び新規ALS2結合低分子量Gタンパク質Rab17の細胞内局在解析

    • Author(s)
      小野鈴花、大友麻子、福田光則、秦野伸二
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24650189
  • 1.  Otomo Asako (50535226)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 93 results
  • 2.  SAITOH Yasushi (70287100)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  OSUGA Hitoshi (60203775)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 4.  IKEDA Joh-E (50266467)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  GONDO Yoichi (40225678)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  MASUYA Hiroshi (40321814)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  INOUE Maki (90321728)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  木村 啓志 (40533625)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 9.  TANAKA Kazunori (10338767)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  ONOE Kyuichiro (50276812)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  AOKI Takuya (70255438)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  國田 竜太 (90449124)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  高木 敦司 (30256101)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  福田 篤 (00638091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  INOMATA Megumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  藤枝 俊宣
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  小池 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  本杉 奈美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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