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sasaki koh  佐々木 光

ORCIDConnect your ORCID iD *help
… Alternative Names

佐々木 光  ササキ コウ

SASAKI Ko  佐々木 光

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Researcher Number 60282638
Affiliation (Current) 2025: 獨協医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2016 – 2021: 獨協医科大学, 医学部, 准教授
2006 – 2010: 獨協医科大学, 医学部, 講師
2009: 医学部, 講師
2007: 自治医科大学, 医学部, 講師
2003 – 2005: 獨協医科大学, 医学部, 助手 … More
2000: 東大, 医学部附属病院, 助手
1999: 東京大学, 医学部・付属病院, 助手
1996 – 1999: 東京大学, 医学部・附属病院, 助手
1997 – 1998: 東京大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Hematology / Biological Sciences
Except Principal Investigator
Hematology / Hematology / Basic Section 54010:Hematology and medical oncology-related / Cell biology / Molecular biology / Biological Sciences
Keywords
Principal Investigator
細胞内情報伝達 / 受容体 / クロストーク / 造血細胞 / STAT pathway / Jak / Ras pathway / GM-CSF / トロンボポエチン
Except Principal Investigator
転写因子 … More / 白血病 / TEL / AML1 / RUNX1 / Cas / 急性巨核芽球性白血病 / ヒストン脱アセチル化酵素阻害剤 / EVI1 / ES / トランスジェニックマウス / SH3 / ES細胞 / ノックインマウス / ノックアウトマウス / 細胞分化 / 遺伝子 / 癌 / 内科 / SKP2 / t(3;21) / RUNX1-EVI1 / ERK / PTPRR / CIZ / transcription factor / GATA-2 / Jagged1 / Smad3 / JNK / TGFβ / Evi-1 / focal adhesion / 細胞接着 / インテグリン / Leukemia / リン酸化 / ベンチジン / AML / microRNA / ALAS-E / Evi1 / 骨髄異形成症候群 / ETS / ドミナント・ネガティブ / アイソフォーム / アポトーシス / MOZ / アセチル化 / ヘモグロビン / 赤芽球 / GATA1 / レトロウイルス / 染色体転座 / 細胞増殖 / EGF受容体 / アデノウイルス / 造血幹細胞 / 分子標的療法 / 発現制御 / 中心体 / CD41 / 骨髄異形成 / 血小板増多 / isoform / chromosomal abnormality / leukemia / 12p13 / ドミナント・ネガティブ効果 / inv(12) / t(12;21) / PPO / GM細胞 / UT-7 / 染色体異常 / nucleo-cytoplasmic shuttling protein / actin stress fiber / matrix metalloproteinase / SH3 domain / 転写制御 / プロモーター / マトリックスメタロプロテアーゼ / 心筋線維 / アクチン / マトリックス・メタロプロテアーゼ / 細胞骨格 / active Notch1 / differentiation / DSL domain / Notch / LTC-IC / CD34 / 遺伝子治療 / ストローマ細胞 / 自己複製能 / EGF様リピート / Notch3 / Notch2 / Notch1 / 活性化型Notch1 / DSLドメイン / Notch蛋白質 / Apoptosis / Stress / Cell growth / 足場非依存性増殖 / 転写伸長因子 / MLL / MEN遺伝子 / MLL遺伝子 / t(11;19)転座型白血病 / 増殖抑制因子 / MAP kinase / zinc finger / 核内蛋白質 / ストレス刺激 / 増殖抑制 / smad3 / myofibril / knockout mouse / subcellular localization / チロシンリン酸化 / シグナル伝達 / アクチン線維 / Phosphorylation / Cell Proliferation / Cell Diffrerntiation / Hematopoietic Cell / Transcription Factor / AML1 gene / 造血細胞 / AML1遺伝子 / メチル化阻害剤 / DNAメチル化 / HDACi / ペプチド / 白血病関連キメラ遺伝子 / レポーター・アッセイ / miRNA / MDS / 予後不良 / 全生存 / 定量PCR法 / Taqman法 / miR-9 / glvcophorin A / β-グロビン / エリスロポエチン / UT-7/GM / MIR-9 / マウス / MIR9 / 造血 / Ruxn1 / Runx1 / 再発率 / 生存率 / 予後不良因子 / 血液内科学 / 巨核球分化 / 赤血球分化 / 造血細胞分化 / TEL-TRKC / ETV6 / キメラマウス / 血小板ペルオキシダーゼ / EPO / TER119 / 巨核球 / 赤血球 / β-globn / GATAl / GATA-1 / PU.1 / 胎仔肝造血 / ピストン脱アセチル化酵素 / 転写活性 / 慢性骨髄性白血病 / 分化抑制 / LG-3 / EBPα / C / replating / がん抑制因子 / p53 / CDKN1A / ピストン脱アセチル化酵素阻害剤 / ETO / GATAL / β-major globin / IALAS-E / EB / ヒストン脱アチヤル化酵素阻害剤 / GFP / tai-to-tail / アンチセンス / DTX2 / RUNX1, RUNX1 / Lox-P配列 / Creリコンビナーゼ / コンディショナルマウス / 非ホジキンリンパ腫 / 急性リンパ性白血病 / 細胞周期 / MLH1遺伝子 / DNAミスマッチ修復 / p53遺伝子 / Rb遺伝子 / p15遺伝子 / p16遺伝子 / 癌抑制遺伝子 / リンパ系腫瘍 / 細胞増幅 Less
  • Research Projects

    (21 results)
  • Research Products

    (73 results)
  • Co-Researchers

    (23 People)
  •  Molecular pathogenesis and molecular therapy in RUNX1-EVI1-type leukemia.

    • Principal Investigator
      Mitani Kinuko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Dokkyo Medical University
  •  Analysis of molecular mechanisms in RUNX1-EVI1-type leukemia

    • Principal Investigator
      Mitani Kinuko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  Analysis of mechanisms in hematopoietic regulation by transcription factors

    • Principal Investigator
      MITANI Kinuko
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  Basic research on new therapy for leukemia by a decoy peptide.

    • Principal Investigator
      MAKI Kazuhiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  The role of TEL in embryonic stem cell differentiation, and identification of a new interacting protein.

    • Principal Investigator
      EGUCHI Mariko
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Ehime University
      Dokkyo Medical University
  •  Analysis of RUNX1-target genes and their functions

    • Principal Investigator
      YAMAGATA Tetsuya
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  Molecular mechanism and molecular targeting therapy in transIocation-related leukemia.

    • Principal Investigator
      MITANI Kinuko
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Dokkyo Medical University
  •  Analysis of mechanisms in hematopoietic regulation and leukemia development

    • Principal Investigator
      MITANI Kinuko
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  発生工学的手法を用いた白血病関連転写因子の機能解析

    • Principal Investigator
      三谷 絹子
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  発生工学的手法を用いた白血病関連転写因子TELの機能解析

    • Principal Investigator
      三谷 絹子
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  Mechanisms in hematopoiesis and leukemogenesis by the transcription factor TEL

    • Principal Investigator
      MITANI Kinuko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Dokkyo Medical University
  •  Ras pathwayとJak/STAT pathwayのクロストークの解析Principal Investigator

    • Principal Investigator
      佐々木 光
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Analyses of Maltipotential Functions of a Novel Signaling Molecule, Cas

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Cell biology
    • Research Institution
      University of Tokyo
  •  新規の細胞内情報伝達分子の遺伝子クローニングと造血細胞の情報伝達機構における機能解析Principal Investigator

    • Principal Investigator
      佐々木 光
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  トロンボポエチン-トロンボポエチン受容体系の機能解析と臨床応用Principal Investigator

    • Principal Investigator
      佐々木 光
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Analyses of a Novel Signaling Molecule, Cas

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Molecular biology
    • Research Institution
      University of Tokyo
  •  Analysis of molecular mechanisms of leukemia development

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Practical development of a novel method for hematopoietic stem cell expansion

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  アデノウイルスを使ったEGF受容体遺伝子導入による造血幹細胞の増幅

    • Principal Investigator
      柴田 洋一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  造血器腫瘍の予後に関する遺伝子診断法の開発

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Functional regulation by phosphorylation of transcription factor AML1 which is involved in leukemogenesis

    • Principal Investigator
      TANAKA Tomotuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      TOKYO UNIVERSITY

All 2022 2021 2020 2019 2018 2017 2016 2010 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation

  • [Journal Article] Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma.2022

    • Author(s)
      Nakamura F, Nakamura Y, Nannya Y, Arai H, Shimbo K, Nakamura Y, Seo S, Sasaki K, Ichikawa M, Ogawa S, Mitani.
    • Journal Title

      Leukemia Research Reports

      Volume: 17 Pages: 100305-100305

    • DOI

      10.1016/j.lrr.2022.100305

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08822
  • [Journal Article] PECAM is an effective and safe anthracycline-containing regimen for patients with relapsed or refractory non-Hodgkin lymphoma.2021

    • Author(s)
      Nakamura F, Arai H, Tokita K, Furuichi S, Sugita-Nagasawa F, Takahashi W, Handa T, Iso H, Tadokoro J, Tsurumi S, Nakamura Y, Nakamura Y, Sasaki K, Seo S, Ichikawa M, Mitani K.
    • Journal Title

      Leukemia & Lympho

      Volume: 62 Issue: 1 Pages: 239-242

    • DOI

      10.1080/10428194.2020.1817442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08822
  • [Journal Article] Development of Philadelphia chromosome-negative acute myeloid leukemia with IDH2 and NPM1 mutations in a patient with chronic myeloid leukemia who showed a major molecular response to tyrosine kinase inhibitor therapy.2021

    • Author(s)
      Nakamura F, Arai H, Nannya Y, Ichikawa M, Furuichi S, Nagasawa F, Takahashi W, Handa T, Nakamura Y, Tanaka H, Nakamura Y, Sasaki K, Miyano S, Ogawa S, Mitani K.
    • Journal Title

      Int J Hematol

      Volume: 113 Issue: 6 Pages: 936-940

    • DOI

      10.1007/s12185-020-03074-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-19H05656
  • [Journal Article] Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia.2021

    • Author(s)
      Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, et al.
    • Journal Title

      Nat comm

      Volume: 12 Issue: 1 Pages: 2833-2833

    • DOI

      10.1038/s41467-021-23097-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-20K22809, KAKENHI-INTERNATIONAL-15K21741, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-20K08127, KAKENHI-PROJECT-20K08723
  • [Journal Article] . Efficacy and safety of romiplostim in refractory aplastic anaemia: a Phase II/III, multicentre, open-label study.2020

    • Author(s)
      Jang JH, Tomiyama Y, Miyazaki K, Nagafuji K, Usuki K, Uoshima N, Fujisaki T, Kosugi H, Matsumura I, Sasaki K, Kizaki M, Sawa M, Hidaka M, Kobayashi N, Ichikawa S, Yonemura Y, Enokitani K, Matsuda A, Ozawa K, Mitani K, Lee JW, Nakao S.
    • Journal Title

      Br J Haematol.

      Volume: 192 Issue: 1 Pages: 190-199

    • DOI

      10.1111/bjh.17190

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08326, KAKENHI-PROJECT-19K08822
  • [Journal Article] The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.2020

    • Author(s)
      Naka K, Ochiai R, Matsubara E, Kondo C, Yang KM, Hoshii T, Araki M, Araki K, Sotomaru Y, Sasaki K, Mitani K, Kim D-W, Ooshima A, Kim SJ.
    • Journal Title

      Nature Comm

      Volume: 11 Issue: 1 Pages: 4681-4681

    • DOI

      10.1038/s41467-020-18491-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-19H01056
  • [Journal Article] RUNX1-EVI1 induces dysplastic hematopoiesis and acute leukemia of the megakaryocytic lineage in mice.2018

    • Author(s)
      Nakamura Y, Ichikawa M, Oda H, Yamazaki I, Sasaki K, Mitani K.
    • Journal Title

      Leukemia Res

      Volume: 74 Pages: 14-20

    • DOI

      10.1016/j.leukres.2018.09.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09858
  • [Journal Article] Chronic myelogenous leukemia in chronic phase transforming into acute leukemia under treatment with dasatinib 4 months after diagnosis.2016

    • Author(s)
      Nakamura Y, Tokita T, Nagasawa F, Takahashi W, Nakamura Y, Sasaki K, Ichikawa M, Mitani K.
    • Journal Title

      Int J Hematol.

      Volume: 103 Issue: 3 Pages: 348-353

    • DOI

      10.1007/s12185-015-1909-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09858
  • [Journal Article] Somatic mosaicism in chronic myeloid leukemia in remission.2016

    • Author(s)
      Mitani K, Nagata Y, Sasaki K, Yoshida K, Chiba K, Tanaka H, Shiraishi Y, Miyano S, Makishima H, Nakamura Y, Nakamura Y, Ichikawa M, Ogawa S.
    • Journal Title

      Blood.

      Volume: 128 Issue: 24 Pages: 2863-2866

    • DOI

      10.1182/blood-2016-06-723494

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16K09858
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1chimera2008

    • Author(s)
      Sasaki K
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Journal Article] Histone deacetylase inhibltors trichostatin A and valprolc acid clrcumvent apoptosls in human leukemic cells expressing the RUNX1 chimera.2008

    • Author(s)
      Sasaki K, Yamagata T, Mltani K.
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008

    • Author(s)
      Sasaki K, Yamagata T, Mitani K
    • Journal Title

      Cancer Sci. 99

      Pages: 414-422

    • NAID

      10024002884

    • Data Source
      KAKENHI-PROJECT-18591086
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera2008

    • Author(s)
      Sasaki K, Yamagata T, Mitani K
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acidcircumvent apoptosis in human leukemic cells expressing the RUNX1chimera2008

    • Author(s)
      Sasaki K
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17659295
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008

    • Author(s)
      Sasaki K, Yamagata T, Mitani K
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390275
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera2008

    • Author(s)
      Sasaki K, Yamagata T, Mitani K
    • Journal Title

      Cancer Science 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008

    • Author(s)
      Sasaki K
    • Journal Title

      Cancer Sci 99

      Pages: 414-422

    • NAID

      10024002884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Journal Article] Chronic ldiopathic myeloflbrosis expressing a novel type of TEL-FDGFRB chimaera responded to imatinib mesylate therapy.2007

    • Author(s)
      Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
    • Journal Title

      Leukemia 21

      Pages: 190-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy2007

    • Author(s)
      Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
    • Journal Title

      Leukemia 21

      Pages: 190-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591085
  • [Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy.2007

    • Author(s)
      Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
    • Journal Title

      Leukemia 21(1)

      Pages: 190-192

    • Data Source
      KAKENHI-PROJECT-18591085
  • [Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy2007

    • Author(s)
      Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K
    • Journal Title

      Leukemia 21

      Pages: 190-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy.2007

    • Author(s)
      K. Tokita, K. Maki, J. Tadokoro, Y. Nakamura, Y. Arai, K. Sasaki, M. Eguchi-Ishimae, M. Eguchi, K. Mitani
    • Journal Title

      Leukemia 21巻1号

      Pages: 190-192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591085
  • [Journal Article] TEL/ETV6 binds to corepressor KAP1 via the HLH domain.2006

    • Author(s)
      Nakamura Y, Yamagata T, Maki K, Sasaki K, Kitabayashi I, Mitani K
    • Journal Title

      Int J Hematol 84

      Pages: 377-380

    • NAID

      10019259868

    • Data Source
      KAKENHI-PROJECT-18591086
  • [Journal Article] novel TEL/ETV6 binding protein KAP1 does not contribute to its transcription-repressive activity2006

    • Author(s)
      Nakamura Y, Maki K, Sasaki K, Kitabayashi I, Mitani K
    • Journal Title

      Int J Hematol 84

      Pages: 377-380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Journal Article] TEL/ETV6 binds to corepressor KAP1 via the HLH domain2006

    • Author(s)
      Nakamura Y, Yamagata T, Maki K, Sasaki K, Kitabayashi I, Mitani K
    • Journal Title

      International Journal of Hematology 84

      Pages: 377-380

    • NAID

      10019259868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Journal Article] A novel TEL/ETV6 binding protein KAP1 does not contribute to its transcription-repnessiue activity.2006

    • Author(s)
      Nakamura Y, Maki K, Sasaki K, Kitabayashi I, Mitani K.
    • Journal Title

      Int J Hematol 84

      Pages: 377-380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM.2005

    • Author(s)
      Takahashi, W., Sasaki, K., Komatsu, N., Mitani, K.
    • Journal Title

      Cancer Sci 96

      Pages: 340-348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhiblts megakaryocytlc maturation in a human leukemia cell line UT-7/GM.2005

    • Author(s)
      Takahashi W, Sasaki K, Komatsu N, Mitani K
    • Journal Title

      Cancer Sci 96

      Pages: 340-348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM2005

    • Author(s)
      Takahashi W, Sasaki K, Komatsu N, Mitani K
    • Journal Title

      Cancer Sci 96

      Pages: 340-348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Journal Article] Functional analysis of a dominant-negative ΔETS TEL/ETV6 isoform.2004

    • Author(s)
      Sasaki, K.
    • Journal Title

      Biochem Biophys Res Comm 317

      Pages: 1128-1137

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004

    • Author(s)
      Sasaki K
    • Journal Title

      Biochem Biophys Res Comm 317

      Pages: 1128-1137

    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.2004

    • Author(s)
      Yamaguchi, Y., Kurokawa, M., Imai, Y., Izutsu, K., Asai, T., Ichikawa, M., Yamamoto, G., Nitta, E., Yamagata, T., Sasaki, K., Mitani K., Ogawa, S., Chiba, S., Hirai, H.
    • Journal Title

      J Biol Chem 279

      Pages: 15630-15638

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] TEL/AML1 shows dominant-negative effects over TEL as well as AML1.2004

    • Author(s)
      Gunji, H., Waga, K., Nakamura, F., Maki, K., Sasaki, K., Nakamura, Y., Mitani, K.
    • Journal Title

      Biochem Biophys Res Comm 322

      Pages: 623-630

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004

    • Author(s)
      Sasaki K
    • Journal Title

      Biochem Biophys Res Comm 317

      Pages: 1128-1137

    • Data Source
      KAKENHI-PROJECT-14657248
  • [Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004

    • Author(s)
      Sasaki, K., Nakamura, Y., Maki, K., Waga, K., Nakamura, F., Arai, H., Imai, Y., Hirai, H., Mitani, K.
    • Journal Title

      Biochem Biophys Res Comm 317

      Pages: 1128-1137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] Leukemia-related transcription factor TEL is negatively regulated through ERK-induced phosphorylation.2004

    • Author(s)
      Maki, K., Arai, H., Waga, K., Sasaki, K., Nakamura, F., Imai, Y., Kurokawa, M., Hirai, H., Mitani K.
    • Journal Title

      Mol Cell Biol 24

      Pages: 3227-3237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells.2003

    • Author(s)
      Waga, K., Nakamura, Y., Maki, K., Arai, H., Yamagata, T., Sasaki, K., Kurokawa, M., Hirai, H., Mitani K.
    • Journal Title

      Oncogene 22

      Pages: 59-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Journal Article] Functional regulation of TEL by p38-induced phosphorylation.2002

    • Author(s)
      Arai, H., Maki, K., Waga, K., Sasaki, K., Nakamura, Y., Imai, Y., Kurokawa, M.,.Hirai, H., Mitani, K.
    • Journal Title

      Biochem Biophys Res Comm 299

      Pages: 116-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370308
  • [Presentation] Clonal evolution and clinical impact of genetic lesions in blast crisis of chronic myeloid leukemia.2021

    • Author(s)
      越智 陽太郎、吉田 健一、南谷 泰仁、佐々木 光、三谷 絹子、小川 誠司等
    • Organizer
      日本血液学会 関東甲信越地方会
    • Data Source
      KAKENHI-PROJECT-19K08822
  • [Presentation] Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic Myeloid Leukemia.2020

    • Author(s)
      Yotaro Ochi, Kenichi Yoshida, Ko Sasaki, Yasuhito Nannya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Satoru Miyano, Kinuko Mitani, Seishi Ogawa, et al.
    • Organizer
      第62回米国血液学会
    • Data Source
      KAKENHI-PROJECT-19K08822
  • [Presentation] 慢性骨髄性白血病の病態進展におけるMIR9の機能.2019

    • Author(s)
      佐々木光、永澤英子、吉田健一、竹田淳恵、白石友一、千葉健一、田中洋子、岡田 愛、宮野 悟、市川 幹、小川誠司、三谷絹子
    • Organizer
      第56回日本臨床分子医学会学術集会.
    • Data Source
      KAKENHI-PROJECT-19K08822
  • [Presentation] RUNX1-EVI1 キメラ遺伝子による白血病モデルマウスの解析.2017

    • Author(s)
      中村由香、市川幹、小田秀明、山崎家春、佐々木光、三谷絹子
    • Organizer
      第54回日本臨床分子医学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09858
  • [Presentation] RUNX1-EVI1 fusion gene induces an acute megakaryoblastic leukemia in mice.2016

    • Author(s)
      Yuka Nakamura, Motoshi Ichikawa, Ieharu Yamazaki, Ko Sasaki, Kinuko Mitani
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-16K09858
  • [Presentation] Molecular pathogenesis of MDS and its clinical implication.2010

    • Author(s)
      Maki K, Sasaki K, Yamagata T, Mitani K.
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Data Source
      KAKENHI-PROJECT-20390275
  • [Presentation] Abnormal expression of mir-9 indicates poor prognosis in AML patients.2010

    • Author(s)
      Maki K, Yamagata T, Sasaki K, Mitani K.
    • Organizer
      15^<th> Congress of EHA.
    • Place of Presentation
      Barcelona
    • Data Source
      KAKENHI-PROJECT-20390275
  • [Presentation] microRNA-9の高発現は急性白血病において予後不良を示す2009

    • Author(s)
      山形哲也, 佐々木光, 牧和宏, 三谷絹子
    • Organizer
      第71回日本血液総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] High expression of microRNA-9 is a hallmark for poor prognosis in acute leukemia patients.2009

    • Author(s)
      Yamagata T, Sasaki K, Maki K, Mitai K.
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20390275
  • [Presentation] microRNA-9の高発現は急性白血病において予後不良を示す2009

    • Author(s)
      山形哲也, 佐々木光, 牧和弘, 三谷絹子
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] ヒストン脱アセチル化酵素阻害薬を用いたRUNX1/EVI1の造腫瘍活性の抑制2008

    • Author(s)
      牧和宏、山形哲也、佐々木光、三谷絹子
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-12
    • Data Source
      KAKENHI-PROJECT-20591140
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光, 山形哲也, 牧和弘, 三谷絹子
    • Organizer
      第70回日本血液総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-20390275
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与2008

    • Author(s)
      佐々木光
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Presentation] microRNA によるTEL の発現制御機構の解析およびMDS 発症への関与の検討2008

    • Author(s)
      佐々木光、山形哲也、牧和弘、三谷絹子
    • Organizer
      第70回日本血液総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] 再発・難治性CD33陽性急性骨髄性白血病に対するCAG-GO療法の安全性と有効性2008

    • Author(s)
      仲村祐子, 新井幸宏, 高橋渉, 鴇田勝哉, 新井ほのか, 半田智幸, 田所治朗, 磯桐子, 鶴見茂治, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] ヒストン脱アセチル化酵素阻害剤を用いたRunx1/Evi1の造腫瘍活性の抑制2008

    • Author(s)
      牧和弘, 佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第70回日本血液総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光, 山形哲也, 牧和宏, 三谷絹子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光, 山形哲也, 牧和宏, 三谷絹子
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] ヒストン脱アセチル化酵素阻害剤を用いたRunx1/Evilの造腫瘍活性の抑制2008

    • Author(s)
      牧和宏, 佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008

    • Author(s)
      佐々木光, 山形哲也, 牧和弘, 三谷絹子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007

    • Author(s)
      佐々木 光
    • Organizer
      第69回日本血液学会総会・第49回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Presentation] Runx1キメラ型白血病細胞に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007

    • Author(s)
      佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第69回日本血液学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007

    • Author(s)
      佐々木 光
    • Organizer
      第69回日本血液学会総会・第49回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Data Source
      KAKENHI-PROJECT-17390283
  • [Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析第69回日本血液学会総会2007

    • Author(s)
      佐々木光
    • Organizer
      第49回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Presentation] 中枢神経原発悪性リンパ腫治療の検討2007

    • Author(s)
      田所治朗, 新井幸宏, 鴇田勝哉高橋渉, 磯桐子, 新井ほのか, 半田智幸, 仲村祐子, 石前峰斉, 江口真理子, 佐々木光, 牧和宏, 山形哲也, 三谷絹子
    • Organizer
      第69回日本血液学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007

    • Author(s)
      佐々木 光
    • Organizer
      第69回日本血液学会総会・第49回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-12
    • Data Source
      KAKENHI-PROJECT-17659295
  • [Presentation] Runx1キメラ型白血病細胞に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007

    • Author(s)
      佐々木光、山形哲也、三谷絹子
    • Organizer
      第69回日本血液学会・第49回日本臨床血液学会(合同総会)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] 多発性骨髄腫におけるビフォスフォネート投与と骨代謝マーカー2006

    • Author(s)
      半田智幸, 高橋渉, 新井ほのか, 田所治朗, 仲村祐子, 石前峰斉, 江口真理子, 佐々木光, 牧和宏, 新井幸宏, 山形哲也, 三谷絹子
    • Organizer
      第68回日本血液学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] 新規TEL結合蛋白KAP-1の同定と機能解析2006

    • Author(s)
      中村由香, 山形哲也, 牧和宏, 佐々木光, 北林一生, 三谷絹子
    • Organizer
      第68回日本血液学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] AMLI/EvilによるC/EBPaの抑制効果2006

    • Author(s)
      鴇田勝哉, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第68回日本血液学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] AML1/Evi1によるC/EBPaの抑制効果2006

    • Author(s)
      鴇田勝哉, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
    • Organizer
      第65回日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18591086
  • [Presentation] ヒストン脱アセチル化酵素阻害剤のAML1キメラ型白血病に対する有用性の検討2005

    • Author(s)
      佐々木光
    • Organizer
      第67回血液学会総会・第47回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-09-18
    • Data Source
      KAKENHI-PROJECT-17016068
  • [Presentation] ヒストン脱アセチル化酵素阻害剤のAML1キメラ型白血病に対する有用性の検討2005

    • Author(s)
      佐々木光
    • Organizer
      第67回血液学会総会・第47回日本臨床血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2005-09-18
    • Data Source
      KAKENHI-PROJECT-17390283
  • 1.  MITANI Kinuko (50251244)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 51 results
  • 2.  MAKI Kazuhiro (50337391)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 33 results
  • 3.  TETSUYA Yamagata (30424047)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 27 results
  • 4.  HIRAI Hisamaru (90181130)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  CHIBA Shigeru (60212049)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  OGAWA Seishi (60292900)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 7.  KUROKAWA Mineo (80312320)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 8.  MARIKO Eguchi (40420781)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 9.  MINENORI Eguchi (50420782)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 10.  HONDA Hiroaki (40245064)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 11.  WAGA Kazuo (00285917)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 12.  中村 由香 (80364595)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 13.  柴田 洋一 (30010474)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  中村 裕一 (20227896)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 15.  市川 幹 (60463840)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 16.  TANAKA Tomotuki (50227154)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TAKAHASHI Tokiharu (30313125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  宮川 清 (40200133)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TAKAHASHI Tsuyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  平野 直人
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  上野 博夫
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  冨山 佳昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  牧島 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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