sasaki koh 佐々木光

… Alternative Names

佐々木光ササキコウ

SASAKI Ko 佐々木光

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Researcher Number	60282638
Affiliation (Current)	2022: 獨協医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 獨協医科大学, 医学部, 准教授 2006 – 2010: 獨協医科大学, 医学部, 講師 2009: 医学部, 講師 2007: 自治医科大学, 医学部, 講師 2003 – 2005: 獨協医科大学, 医学部, 助手 … More 2000: 東大, 医学部附属病院, 助手 1999: 東京大学, 医学部・付属病院, 助手 1996 – 1999: 東京大学, 医学部・附属病院, 助手 1997 – 1998: 東京大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences Except Principal Investigator Hematology / Hematology / Biological Sciences / Molecular biology / Cell biology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 細胞内情報伝達 / 受容体 / トロンボポエチン / GM-CSF / Ras pathway / Jak / STAT pathway / 造血細胞 / クロストーク Except Principal Investigator TEL … More / 白血病 / 転写因子 / RUNX1 / AML1 / トランスジェニックマウス / ES / EVI1 / ヒストン脱アセチル化酵素阻害剤 / 急性巨核芽球性白血病 / Cas / 細胞分化 / ノックアウトマウス / ノックインマウス / ES細胞 / SH3 / 造血幹細胞 / アデノウイルス / EGF受容体 / 細胞増殖 / 染色体転座 / レトロウイルス / GATA1 / 赤芽球 / ヘモグロビン / アセチル化 / MOZ / アポトーシス / アイソフォーム / ドミナント・ネガティブ / ETS / 骨髄異形成症候群 / Evi1 / ALAS-E / microRNA / AML / ベンチジン / リン酸化 / Leukemia / インテグリン / 細胞接着 / focal adhesion / Evi-1 / TGFβ / JNK / Smad3 / Jagged1 / GATA-2 / transcription factor / CIZ / PTPRR / ERK / RUNX1-EVI1 / t(3;21) / SKP2 / 内科 / 癌 / 遺伝子 / 細胞増幅 / リンパ系腫瘍 / 癌抑制遺伝子 / p16遺伝子 / p15遺伝子 / Rb遺伝子 / p53遺伝子 / DNAミスマッチ修復 / MLH1遺伝子 / 細胞周期 / 急性リンパ性白血病 / 非ホジキンリンパ腫 / コンディショナルマウス / Creリコンビナーゼ / Lox-P配列 / RUNX1, RUNX1 / DTX2 / アンチセンス / tai-to-tail / GFP / ヒストン脱アチヤル化酵素阻害剤 / EB / IALAS-E / β-major globin / GATAL / ETO / ピストン脱アセチル化酵素阻害剤 / CDKN1A / p53 / がん抑制因子 / replating / C / EBPα / LG-3 / 分化抑制 / 慢性骨髄性白血病 / 転写活性 / ピストン脱アセチル化酵素 / 胎仔肝造血 / PU.1 / GATA-1 / GATAl / β-globn / 赤血球 / 巨核球 / TER119 / EPO / 血小板ペルオキシダーゼ / キメラマウス / ETV6 / TEL-TRKC / 造血細胞分化 / 赤血球分化 / 巨核球分化 / 血液内科学 / 予後不良因子 / 生存率 / 再発率 / Runx1 / Ruxn1 / 造血 / MIR9 / マウス / MIR-9 / UT-7/GM / エリスロポエチン / β-グロビン / glvcophorin A / miR-9 / Taqman法 / 定量PCR法 / 全生存 / 予後不良 / MDS / miRNA / レポーター・アッセイ / 白血病関連キメラ遺伝子 / ペプチド / HDACi / DNAメチル化 / メチル化阻害剤 / AML1遺伝子 / 造血細胞 / AML1 gene / Transcription Factor / Hematopoietic Cell / Cell Diffrerntiation / Cell Proliferation / Phosphorylation / アクチン線維 / シグナル伝達 / チロシンリン酸化 / subcellular localization / knockout mouse / myofibril / smad3 / 増殖抑制 / ストレス刺激 / 核内蛋白質 / zinc finger / MAP kinase / 増殖抑制因子 / t(11;19)転座型白血病 / MLL遺伝子 / MEN遺伝子 / MLL / 転写伸長因子 / 足場非依存性増殖 / Cell growth / Stress / Apoptosis / Notch蛋白質 / DSLドメイン / 活性化型Notch1 / Notch1 / Notch2 / Notch3 / EGF様リピート / 自己複製能 / ストローマ細胞 / 遺伝子治療 / CD34 / LTC-IC / Notch / DSL domain / differentiation / active Notch1 / 細胞骨格 / マトリックス・メタロプロテアーゼ / アクチン / 心筋線維 / マトリックスメタロプロテアーゼ / プロモーター / 転写制御 / SH3 domain / matrix metalloproteinase / actin stress fiber / nucleo-cytoplasmic shuttling protein / 染色体異常 / UT-7 / GM細胞 / PPO / t(12;21) / inv(12) / ドミナント・ネガティブ効果 / 12p13 / leukemia / chromosomal abnormality / isoform / 血小板増多 / 骨髄異形成 / CD41 / 中心体 / 発現制御 / 分子標的療法 Less

Molecular pathogenesis and molecular therapy in RUNX1-EVI1-type leukemia.
- Principal Investigator
  
  Mitani Kinuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Dokkyo Medical University
Analysis of molecular mechanisms in RUNX1-EVI1-type leukemia
- Principal Investigator
  
  Mitani Kinuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
Analysis of mechanisms in hematopoietic regulation by transcription factors
- Principal Investigator
  
  MITANI Kinuko
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
Basic research on new therapy for leukemia by a decoy peptide.
- Principal Investigator
  
  MAKI Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
The role of TEL in embryonic stem cell differentiation, and identification of a new interacting protein.
- Principal Investigator
  
  EGUCHI Mariko
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Ehime University
  Dokkyo Medical University
Analysis of RUNX1-target genes and their functions
- Principal Investigator
  
  YAMAGATA Tetsuya
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
Molecular mechanism and molecular targeting therapy in transIocation-related leukemia.
- Principal Investigator
  
  MITANI Kinuko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Dokkyo Medical University
Analysis of mechanisms in hematopoietic regulation and leukemia development
- Principal Investigator
  
  MITANI Kinuko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
発生工学的手法を用いた白血病関連転写因子の機能解析
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
発生工学的手法を用いた白血病関連転写因子TELの機能解析
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
Mechanisms in hematopoiesis and leukemogenesis by the transcription factor TEL
- Principal Investigator
  
  MITANI Kinuko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo Medical University
Ras pathwayとJak/STAT pathwayのクロストークの解析Principal Investigator
- Principal Investigator
  
  佐々木光
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Analyses of Maltipotential Functions of a Novel Signaling Molecule, Cas
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Cell biology
- Research Institution
  University of Tokyo
新規の細胞内情報伝達分子の遺伝子クローニングと造血細胞の情報伝達機構における機能解析Principal Investigator
- Principal Investigator
  
  佐々木光
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
トロンボポエチン-トロンボポエチン受容体系の機能解析と臨床応用Principal Investigator
- Principal Investigator
  
  佐々木光
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Analyses of a Novel Signaling Molecule, Cas
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  University of Tokyo
Analysis of molecular mechanisms of leukemia development
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Practical development of a novel method for hematopoietic stem cell expansion
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
アデノウイルスを使ったEGF受容体遺伝子導入による造血幹細胞の増幅
- Principal Investigator
  
  柴田洋一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
造血器腫瘍の予後に関する遺伝子診断法の開発
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Functional regulation by phosphorylation of transcription factor AML1 which is involved in leukemogenesis
- Principal Investigator
  
  TANAKA Tomotuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  TOKYO UNIVERSITY

[Journal Article] Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma.2022
- Author(s)
  Nakamura F, Nakamura Y, Nannya Y, Arai H, Shimbo K, Nakamura Y, Seo S, Sasaki K, Ichikawa M, Ogawa S, Mitani.
- Journal Title
  
  Leukemia Research Reports
  
  Volume: 17
- DOI
  10.1016/j.lrr.2022.100305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08822
[Journal Article] PECAM is an effective and safe anthracycline-containing regimen for patients with relapsed or refractory non-Hodgkin lymphoma.2021
- Author(s)
  Nakamura　F, Arai　H, Tokita　K, Furuichi　S, Sugita-Nagasawa　F, Takahashi　W, Handa　T, Iso　H, Tadokoro　J, Tsurumi　S, Nakamura　Y, Nakamura　Y, Sasaki　K, Seo　S, Ichikawa　M, Mitani K.
- Journal Title
  
  Leukemia & Lympho
  
  Volume: 62 Pages: 239-242
- DOI
  10.1080/10428194.2020.1817442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08822
[Journal Article] Development of Philadelphia chromosome-negative acute myeloid leukemia with IDH2 and NPM1 mutations in a patient with chronic myeloid leukemia who showed a major molecular response to tyrosine kinase inhibitor therapy2021
- Author(s)
  Nakamura F, Arai H, Nannya Y, Ichikawa M, Furuichi S, Nagasawa F, Takahashi W, Handa T, Nakamura Y, Tanaka H, Nakamura Y, Sasaki K, Miyano S, Ogawa S, Mitani K.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 113 Pages: 936-940
- DOI
  10.1007/s12185-020-03074-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-19H05656
[Journal Article] Efficacy and safety of romiprostim in refractory aplastic anemia: a Phase II/III, multicenter, open-label study.2021
- Author(s)
  Jang JH, Tomiyama Y, Miyazaki K, Nagafuji K, Usuki K, Uoshima N, Fujisaki T, Kosugi H, Matsumura I, Sasaki K, Kizaki M, Sawa M, Hidaka M, Kobayashi N, Ichikawa S, Yonemura Y, Enokitani K, Matsuda A, Ozawa K, Mitani K, Lee JW, Nakao S.
- Journal Title
  
  Br J Haematol
  
  Volume: 192 Pages: 190-199
- DOI
  10.1111/bjh.17190
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08326, KAKENHI-PROJECT-19K08822
[Journal Article] Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia2021
- Author(s)
  Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, et al.
- Journal Title
  
  Nat Commun
  
  Volume: 12 Pages: 2833-2833
- DOI
  10.1038/s41467-021-23097-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-20K22809, KAKENHI-INTERNATIONAL-15K21741, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-20K08127, KAKENHI-PROJECT-20K08723
[Journal Article] The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells2020
- Author(s)
  Naka K, Ochiai R, Matsubara E, Kondo C, Yang KM, Hoshii T, Araki M, Araki K, Sotomaru Y, Sasaki K, Mitani K, Kim D-W, Ooshima A, Kim SJ.
- Journal Title
  
  Nat. Commun.
  
  Volume: 11 Pages: 1-15
- DOI
  10.1038/s41467-020-18491-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08822, KAKENHI-PROJECT-19H03690, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-19H01056
[Journal Article] RUNX1-EVI1 induces dysplastic hematopoiesis and acute leukemia of the megakaryocytic lineage in mice.2018
- Author(s)
  Nakamura Y, Ichikawa M, Oda H, Yamazaki I, Sasaki K, Mitani K.
- Journal Title
  
  Leukemia Res
  
  Volume: 74 Pages: 14-20
- DOI
  10.1016/j.leukres.2018.09.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09858
[Journal Article] Chronic myelogenous leukemia in chronic phase transforming into acute leukemia under treatment with dasatinib 4 months after diagnosis.2016
- Author(s)
  Nakamura Y, Tokita T, Nagasawa F, Takahashi W, Nakamura Y, Sasaki K, Ichikawa M, Mitani K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 103 Pages: 348-353
- DOI
  10.1007/s12185-015-1909-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09858
[Journal Article] Somatic mosaicism in chronic myeloid leukemia in remission.2016
- Author(s)
  Mitani K, Nagata Y, Sasaki K, Yoshida K, Chiba K, Tanaka H, Shiraishi Y, Miyano S, Makishima H, Nakamura Y, Nakamura Y, Ichikawa M, Ogawa S.
- Journal Title
  
  Blood
  
  Volume: 128 Pages: 2863-2866
- DOI
  10.1182/blood-2016-06-723494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16K09858
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1chimera2008
- Author(s)
  Sasaki K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390283
[Journal Article] Histone deacetylase inhibltors trichostatin A and valprolc acid clrcumvent apoptosls in human leukemic cells expressing the RUNX1 chimera.2008
- Author(s)
  Sasaki K, Yamagata T, Mltani K.
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016068
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008
- Author(s)
  Sasaki K, Yamagata T, Mitani K
- Journal Title
  
  Cancer Sci. 99
  
  Pages: 414-422
- NAID
  10024002884
- Data Source
  KAKENHI-PROJECT-18591086
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera2008
- Author(s)
  Sasaki K, Yamagata T, Mitani K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390283
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acidcircumvent apoptosis in human leukemic cells expressing the RUNX1chimera2008
- Author(s)
  Sasaki K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659295
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008
- Author(s)
  Sasaki K, Yamagata T, Mitani K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390275
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera2008
- Author(s)
  Sasaki K, Yamagata T, Mitani K
- Journal Title
  
  Cancer Science 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591086
[Journal Article] Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera.2008
- Author(s)
  Sasaki K
- Journal Title
  
  Cancer Sci 99
  
  Pages: 414-422
- NAID
  10024002884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016068
[Journal Article] Chronic ldiopathic myeloflbrosis expressing a novel type of TEL-FDGFRB chimaera responded to imatinib mesylate therapy.2007
- Author(s)
  Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
- Journal Title
  
  Leukemia 21
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016068
[Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy2007
- Author(s)
  Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
- Journal Title
  
  Leukemia 21
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591085
[Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy.2007
- Author(s)
  Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K.
- Journal Title
  
  Leukemia 21(1)
  
  Pages: 190-192
- Data Source
  KAKENHI-PROJECT-18591085
[Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy2007
- Author(s)
  Tokita K, Maki K, Tadokoro J, Nakamura Y, Arai Y, Sasaki K, Eguchi-Ishimae M, Eguchi M, Mitani K
- Journal Title
  
  Leukemia 21
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390283
[Journal Article] Chronic idiopathic myelofibrosis expressing a novel type of TEL-PDGFRB chimaera responded to imatinib mesylate therapy.2007
- Author(s)
  K. Tokita, K. Maki, J. Tadokoro, Y. Nakamura, Y. Arai, K. Sasaki, M. Eguchi-Ishimae, M. Eguchi, K. Mitani
- Journal Title
  
  Leukemia 21巻1号
  
  Pages: 190-192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591085
[Journal Article] TEL/ETV6 binds to corepressor KAP1 via the HLH domain.2006
- Author(s)
  Nakamura Y, Yamagata T, Maki K, Sasaki K, Kitabayashi I, Mitani K
- Journal Title
  
  Int J Hematol 84
  
  Pages: 377-380
- NAID
  10019259868
- Data Source
  KAKENHI-PROJECT-18591086
[Journal Article] novel TEL/ETV6 binding protein KAP1 does not contribute to its transcription-repressive activity2006
- Author(s)
  Nakamura Y, Maki K, Sasaki K, Kitabayashi I, Mitani K
- Journal Title
  
  Int J Hematol 84
  
  Pages: 377-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390283
[Journal Article] TEL/ETV6 binds to corepressor KAP1 via the HLH domain2006
- Author(s)
  Nakamura Y, Yamagata T, Maki K, Sasaki K, Kitabayashi I, Mitani K
- Journal Title
  
  International Journal of Hematology 84
  
  Pages: 377-380
- NAID
  10019259868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591086
[Journal Article] A novel TEL/ETV6 binding protein KAP1 does not contribute to its transcription-repnessiue activity.2006
- Author(s)
  Nakamura Y, Maki K, Sasaki K, Kitabayashi I, Mitani K.
- Journal Title
  
  Int J Hematol 84
  
  Pages: 377-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016068
[Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM.2005
- Author(s)
  Takahashi, W., Sasaki, K., Komatsu, N., Mitani, K.
- Journal Title
  
  Cancer Sci 96
  
  Pages: 340-348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhiblts megakaryocytlc maturation in a human leukemia cell line UT-7/GM.2005
- Author(s)
  Takahashi W, Sasaki K, Komatsu N, Mitani K
- Journal Title
  
  Cancer Sci 96
  
  Pages: 340-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016068
[Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM2005
- Author(s)
  Takahashi W, Sasaki K, Komatsu N, Mitani K
- Journal Title
  
  Cancer Sci 96
  
  Pages: 340-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390283
[Journal Article] Functional analysis of a dominant-negative ΔETS TEL/ETV6 isoform.2004
- Author(s)
  Sasaki, K.
- Journal Title
  
  Biochem Biophys Res Comm 317
  
  Pages: 1128-1137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004
- Author(s)
  Sasaki K
- Journal Title
  
  Biochem Biophys Res Comm 317
  
  Pages: 1128-1137
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.2004
- Author(s)
  Yamaguchi, Y., Kurokawa, M., Imai, Y., Izutsu, K., Asai, T., Ichikawa, M., Yamamoto, G., Nitta, E., Yamagata, T., Sasaki, K., Mitani K., Ogawa, S., Chiba, S., Hirai, H.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 15630-15638
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] TEL/AML1 shows dominant-negative effects over TEL as well as AML1.2004
- Author(s)
  Gunji, H., Waga, K., Nakamura, F., Maki, K., Sasaki, K., Nakamura, Y., Mitani, K.
- Journal Title
  
  Biochem Biophys Res Comm 322
  
  Pages: 623-630
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004
- Author(s)
  Sasaki K
- Journal Title
  
  Biochem Biophys Res Comm 317
  
  Pages: 1128-1137
- Data Source
  KAKENHI-PROJECT-14657248
[Journal Article] Functional analysis of a dominant-negative DETS TEL/ETV6 isoform.2004
- Author(s)
  Sasaki, K., Nakamura, Y., Maki, K., Waga, K., Nakamura, F., Arai, H., Imai, Y., Hirai, H., Mitani, K.
- Journal Title
  
  Biochem Biophys Res Comm 317
  
  Pages: 1128-1137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] Leukemia-related transcription factor TEL is negatively regulated through ERK-induced phosphorylation.2004
- Author(s)
  Maki, K., Arai, H., Waga, K., Sasaki, K., Nakamura, F., Imai, Y., Kurokawa, M., Hirai, H., Mitani K.
- Journal Title
  
  Mol Cell Biol 24
  
  Pages: 3227-3237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells.2003
- Author(s)
  Waga, K., Nakamura, Y., Maki, K., Arai, H., Yamagata, T., Sasaki, K., Kurokawa, M., Hirai, H., Mitani K.
- Journal Title
  
  Oncogene 22
  
  Pages: 59-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Journal Article] Functional regulation of TEL by p38-induced phosphorylation.2002
- Author(s)
  Arai, H., Maki, K., Waga, K., Sasaki, K., Nakamura, Y., Imai, Y., Kurokawa, M.,.Hirai, H., Mitani, K.
- Journal Title
  
  Biochem Biophys Res Comm 299
  
  Pages: 116-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370308
[Presentation] Clonal evolution and clinical impact of genetic lesions in blast crisis of chronic myeloid leukemia.2021
- Author(s)
  越智　陽太郎、吉田　健一、南谷　泰仁、佐々木　光、三谷　絹子、小川　誠司等
- Organizer
  日本血液学会　関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-19K08822
[Presentation] Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic Myeloid Leukemia.2020
- Author(s)
  Yotaro Ochi, Kenichi Yoshida, Ko Sasaki, Yasuhito Nannya, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Satoru Miyano, Kinuko Mitani, Seishi Ogawa, et al.
- Organizer
  第62回米国血液学会
- Data Source
  KAKENHI-PROJECT-19K08822
[Presentation] 慢性骨髄性白血病の病態進展におけるMIR9の機能.2019
- Author(s)
  佐々木光、永澤英子、吉田健一、竹田淳恵、白石友一、千葉健一、田中洋子、岡田　愛、宮野　悟、市川　幹、小川誠司、三谷絹子
- Organizer
  第56回日本臨床分子医学会学術集会.
- Data Source
  KAKENHI-PROJECT-19K08822
[Presentation] RUNX1-EVI1 キメラ遺伝子による白血病モデルマウスの解析.2017
- Author(s)
  中村由香、市川幹、小田秀明、山崎家春、佐々木光、三谷絹子
- Organizer
  第54回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09858
[Presentation] RUNX1-EVI1 fusion gene induces an acute megakaryoblastic leukemia in mice.2016
- Author(s)
  Yuka Nakamura, Motoshi Ichikawa, Ieharu Yamazaki, Ko Sasaki, Kinuko Mitani
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09858
[Presentation] Molecular pathogenesis of MDS and its clinical implication.2010
- Author(s)
  Maki K, Sasaki K, Yamagata T, Mitani K.
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20390275
[Presentation] Abnormal expression of mir-9 indicates poor prognosis in AML patients.2010
- Author(s)
  Maki K, Yamagata T, Sasaki K, Mitani K.
- Organizer
  15^<th> Congress of EHA.
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-20390275
[Presentation] microRNA-9の高発現は急性白血病において予後不良を示す2009
- Author(s)
  山形哲也, 佐々木光, 牧和宏, 三谷絹子
- Organizer
  第71回日本血液総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] High expression of microRNA-9 is a hallmark for poor prognosis in acute leukemia patients.2009
- Author(s)
  Yamagata T, Sasaki K, Maki K, Mitai K.
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20390275
[Presentation] microRNA-9の高発現は急性白血病において予後不良を示す2009
- Author(s)
  山形哲也, 佐々木光, 牧和弘, 三谷絹子
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] ヒストン脱アセチル化酵素阻害薬を用いたRUNX1/EVI1の造腫瘍活性の抑制2008
- Author(s)
  牧和宏、山形哲也、佐々木光、三谷絹子
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-20591140
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光, 山形哲也, 牧和弘, 三谷絹子
- Organizer
  第70回日本血液総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20390275
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与2008
- Author(s)
  佐々木光
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17016068
[Presentation] microRNA によるTEL の発現制御機構の解析およびMDS 発症への関与の検討2008
- Author(s)
  佐々木光、山形哲也、牧和弘、三谷絹子
- Organizer
  第70回日本血液総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] 再発・難治性CD33陽性急性骨髄性白血病に対するCAG-GO療法の安全性と有効性2008
- Author(s)
  仲村祐子, 新井幸宏, 高橋渉, 鴇田勝哉, 新井ほのか, 半田智幸, 田所治朗, 磯桐子, 鶴見茂治, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] ヒストン脱アセチル化酵素阻害剤を用いたRunx1/Evi1の造腫瘍活性の抑制2008
- Author(s)
  牧和弘, 佐々木光, 山形哲也, 三谷絹子
- Organizer
  第70回日本血液総会
- Place of Presentation
  京都国際会議場
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光, 山形哲也, 牧和宏, 三谷絹子
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光, 山形哲也, 牧和宏, 三谷絹子
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] ヒストン脱アセチル化酵素阻害剤を用いたRunx1/Evilの造腫瘍活性の抑制2008
- Author(s)
  牧和宏, 佐々木光, 山形哲也, 三谷絹子
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-17016068
[Presentation] microRNAによるTELの発現制御機構の解析およびMDS発症への関与の検討2008
- Author(s)
  佐々木光, 山形哲也, 牧和弘, 三谷絹子
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007
- Author(s)
  佐々木光
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17016068
[Presentation] Runx1キメラ型白血病細胞に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007
- Author(s)
  佐々木光, 山形哲也, 三谷絹子
- Organizer
  第69回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007
- Author(s)
  佐々木光
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17390283
[Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析第69回日本血液学会総会2007
- Author(s)
  佐々木光
- Organizer
  第49回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17016068
[Presentation] 中枢神経原発悪性リンパ腫治療の検討2007
- Author(s)
  田所治朗, 新井幸宏, 鴇田勝哉高橋渉, 磯桐子, 新井ほのか, 半田智幸, 仲村祐子, 石前峰斉, 江口真理子, 佐々木光, 牧和宏, 山形哲也, 三谷絹子
- Organizer
  第69回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] RUNX1キメラ型白血病に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007
- Author(s)
  佐々木光
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17659295
[Presentation] Runx1キメラ型白血病細胞に対するヒストン脱アセチル化酵素阻害剤の作用機序の解析2007
- Author(s)
  佐々木光、山形哲也、三谷絹子
- Organizer
  第69回日本血液学会・第49回日本臨床血液学会(合同総会)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] 多発性骨髄腫におけるビフォスフォネート投与と骨代謝マーカー2006
- Author(s)
  半田智幸, 高橋渉, 新井ほのか, 田所治朗, 仲村祐子, 石前峰斉, 江口真理子, 佐々木光, 牧和宏, 新井幸宏, 山形哲也, 三谷絹子
- Organizer
  第68回日本血液学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] 新規TEL結合蛋白KAP-1の同定と機能解析2006
- Author(s)
  中村由香, 山形哲也, 牧和宏, 佐々木光, 北林一生, 三谷絹子
- Organizer
  第68回日本血液学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] AMLI/EvilによるC/EBPaの抑制効果2006
- Author(s)
  鴇田勝哉, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
- Organizer
  第68回日本血液学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] AML1/Evi1によるC/EBPaの抑制効果2006
- Author(s)
  鴇田勝哉, 牧和宏, 佐々木光, 山形哲也, 三谷絹子
- Organizer
  第65回日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591086
[Presentation] ヒストン脱アセチル化酵素阻害剤のAML1キメラ型白血病に対する有用性の検討2005
- Author(s)
  佐々木光
- Organizer
  第67回血液学会総会・第47回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2005-09-18
- Data Source
  KAKENHI-PROJECT-17016068
[Presentation] ヒストン脱アセチル化酵素阻害剤のAML1キメラ型白血病に対する有用性の検討2005
- Author(s)
  佐々木光
- Organizer
  第67回血液学会総会・第47回日本臨床血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2005-09-18
- Data Source
  KAKENHI-PROJECT-17390283

1. MITANI Kinuko (50251244)

# of Collaborated Projects: 16 results

# of Collaborated Products: 53 results
2. MAKI Kazuhiro (50337391)

# of Collaborated Projects: 10 results

# of Collaborated Products: 33 results
3. TETSUYA Yamagata (30424047)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
4. HIRAI Hisamaru (90181130)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. CHIBA Shigeru (60212049)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. OGAWA Seishi (60292900)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
7. KUROKAWA Mineo (80312320)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. MARIKO Eguchi (40420781)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
9. MINENORI Eguchi (50420782)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
10. HONDA Hiroaki (40245064)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. WAGA Kazuo (00285917)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
12. 中村由香 (80364595)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
13. 柴田洋一 (30010474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 中村裕一 (20227896)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
15. 市川幹 (60463840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
16. TANAKA Tomotuki (50227154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKAHASHI Tokiharu (30313125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 宮川清 (40200133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAKAHASHI Tsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 平野直人

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 上野博夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NANYA Yasuhito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. SANADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. Makishima Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
25. HOSHII Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 冨山佳昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 越智陽太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 細谷紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 荒木喜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 外丸祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

sasaki koh 佐々木 光

佐々木 光 ササキ コウ

SASAKI Ko 佐々木 光

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Ras pathwayとJak/STAT pathwayのクロストークの解析Principal Investigator

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新規の細胞内情報伝達分子の遺伝子クローニングと造血細胞の情報伝達機構における機能解析Principal Investigator

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トロンボポエチン-トロンボポエチン受容体系の機能解析と臨床応用Principal Investigator

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sasaki koh 佐々木光

佐々木光ササキコウ

SASAKI Ko 佐々木光