Yasukawa Takashi 安川孝史

… Alternative Names

YASUKAWA Takashi 安川孝史

安川孝史ヤスカワタカシ

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Researcher Number	60291936
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系基礎医学部門, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 高知大学, 教育研究部医療学系基礎医学部門, 講師 2015 – 2020: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2012 – 2014: 高知大学, 教育研究部医療学系, 助教 2009 – 2011: Kochi University, 教育研究部・医療学系, 助教 2000 – 2001: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / General physiology / Neurochemistry/Neuropharmacology Except Principal Investigator Neurology
Keywords	Principal Investigator ユビキチンリガーゼ / アルツハイマー病 / アミロイドβ / 転写伸長因子 / BRI3 / BRI2 / NRBP1 / 神経分化 / Elongin A / 発生 … More / 分化 / 受精 / 遺伝 / パニング法 / 細胞死 / 細胞死拮抗因子 / 受容体 / 神経細胞死 … More Except Principal Investigator receptor / serine isomerase / dimerization / neurodegenerative disease / Alzheimer's disease / Humanin / βFGF / IGF-I / 生体内発現 / ADNF / bFGF / IGF-1 / 分泌機構 / 構造機能相関 / HN Less

アルツハイマー病の新規治療薬の開発に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索Principal Investigator
- Principal Investigator
  
  安川孝史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kochi University
Discovery of NRBP1-Ubiquitin Ligase Inhibitors for the Creation of Novel Alzheimer's Disease TherapeuticsPrincipal Investigator
- Principal Investigator
  
  Yasukawa Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kochi University
Basic research for the development of therapeutic drugs for Alzheimer's disease targeting a novel ubiquitin ligasePrincipal Investigator
- Principal Investigator
  
  Yasukawa Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kochi University
Identification of target genes of transcription elongation factor Elongin A and analysis of its regulationPrincipal Investigator
- Principal Investigator
  
  Yasukawa Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kochi University
Role of transcription factor Elongin A with E3 activity in mouse neural developmentPrincipal Investigator
- Principal Investigator
  
  YASUKAWA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kochi University
Role of mammalian transcription elongation factor Elongin A in mouse neural developmentPrincipal Investigator
- Principal Investigator
  
  YASUKAWA Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kochi University
Detailed characterization of Humanin, a newly identified anti-Alzheimer's disease peptide and potential starting point for development of the first curative therapy for Alzheimer's disease
- Principal Investigator
  
  NISHIMOTO Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  KEIO UNIVERSITY
アルツハイマー病遺伝子が誘導する神経細胞死抑制因子受容体の同定と機能解析Principal Investigator
- Principal Investigator
  
  安川孝史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Keio University

All 2021 2020 2019 2017 2016 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation2020
- Author(s)
  Yasukawa T, Tsutsui A, Tomomori-Sato C, Sato S, Saraf A, Washburn MP, Florens L, Terada T, Shimizu K, Conaway RC, Conaway JW, Aso T.
- Journal Title
  
  Cell Reports
  
  Volume: 30 Issue: 10 Pages: 3478-3491
- DOI
  10.1016/j.celrep.2020.02.059
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06855, KAKENHI-PROJECT-18K06959
[Journal Article] Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.2017
- Author(s)
  Weems JC, Slaughter BD, Unruh JR, Boeing S, Hall SM, McLaird MB, Yasukawa T, Aso T, Svejstrup JQ, Conaway JW, Conaway RC
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 16 Pages: 6431-6437
- DOI
  10.1074/jbc.c117.777946
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08177, KAKENHI-PROJECT-15K08279
[Journal Article] Transcriptional properties of Mammalian elongin A and its role in stress response.2013
- Author(s)
  Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway RC, Conaway JW, Aso T,
- Journal Title
  
  J Biol Chem.
  
  Volume: 288(34) Issue: 34 Pages: 24302-24315
- DOI
  10.1074/jbc.m113.496703
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23134502, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24590279, KAKENHI-PROJECT-24590357, KAKENHI-PROJECT-24590373, KAKENHI-PUBLICLY-25134708
[Journal Article] Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.2012
- Author(s)
  Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T.
- Journal Title
  
  Cell Rep
  
  Volume: 2(5) Issue: 5 Pages: 1129-36
- DOI
  10.1016/j.celrep.2012.09.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700878, KAKENHI-PUBLICLY-23134502, KAKENHI-PROJECT-24590279, KAKENHI-PROJECT-24590357, KAKENHI-PROJECT-24590373, KAKENHI-PROJECT-24659121, KAKENHI-PROJECT-24689016, KAKENHI-PLANNED-24118002
[Journal Article] Degradation of p21^<Cip1> through APC/ C^<Cdc20> mediated ubiquitylation is inhibited by cyclin dependent kinase 2 in cardiomyocytes2011
- Author(s)
  Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, and Kitajima S
- Journal Title
  
  J. Biol. Chem
  
  Volume: Vol.286 Pages: 44057-44066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590233
[Patent] 認知症治療薬のスクリーニング方法2019
- Inventor(s)
  麻生悌二郎、安川孝史
- Industrial Property Rights Holder
  麻生悌二郎、安川孝史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-088444
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K06855
[Presentation] NRBP1-ユビキチンリガーゼは生理的抗アルツハイマー病因子であるBRI2/BRI3の分解を制御する2021
- Author(s)
  安川孝史, 筒井文, 佐藤チエリ, 佐藤滋生, Anita Saraf, Michael P Washburn, Laurence Florens, 寺田透, 清水謙多郎, Ronald C Conaway, Joan W Conaway, 麻生悌二郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06769
[Presentation] ChIP-sequence解析を用いた転写伸長因子Elongin Aの標的遺伝子の同定2016
- Author(s)
  安川孝史 , 筒井文 , 佐藤チエリ , 佐藤滋生 , Ronald C. Conaway , Joan W. Conaway , 麻生悌二郎
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K08177
[Presentation] Role of Transcription Elongation Factor Elongin A in The Sensory Nervous System Development2012
- Author(s)
  Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡（福岡）
- Data Source
  KAKENHI-PROJECT-24590279
[Presentation] Transcriptional elongation factor Elongin A regulates retinoic acid-induced gene expression during neuronal differentiation of embryonic stem cells2011
- Author(s)
  Takashi Yasukawa
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-21590233
[Presentation] Transcriptional elongation factor Elongin A regulates retinoic acid-induced gene expression during neuronal differentiation of embryonic stem cells2011
- Author(s)
  Takashi Yasukawa
- Organizer
  日本分子生物学
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21590233
[Presentation] Elongin A複合体によるRNA polymerase IIポリユビキチン化の制御2010
- Author(s)
  安川孝史
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21590233
[Presentation] Elongin A複合体によるRNA polymerase IIポリユビキチン化の制御2010
- Author(s)
  安川孝史
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21590233
[Presentation] 転写伸長因子Elongin Aの標的遺伝子の網羅的探索
- Author(s)
  安川孝史, 筒井文, 村岡拓也, 佐藤チエリ, 佐藤滋生, Ronald C Conaway, Joan W Conaway, 北嶋繁孝, 麻生悌二郎
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590279
[Presentation] 感覚神経系の発生・分化におけるElongin Aの標的遺伝子の同定
- Author(s)
  安川孝史, 村岡拓也, 筒井文, 佐藤チエリ, 佐藤滋生, 川内潤也, 井上允, 北嶋繁孝, Ronald C Conaway, Joan W Conaway, 麻生悌二郎
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590279
[Presentation] ストレス応答におけるmammalian Elongin Aの特徴と役割
- Author(s)
  井上允, 川内潤也, 安川孝史, Ronald C Conaway, Joan W Conaway, 麻生悌二郎, 北嶋繁孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24590279

1. NISHIMOTO Ikuo (80180652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NIIKURA Takako (10301491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASHIMOTO Yuichi (00317330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUOKA Masaaki (70222297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 田島裕久 (50306833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TSUTSUI Aya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KAWAUCHI Junya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yasukawa Takashi 安川 孝史

YASUKAWA Takashi 安川 孝史

安川 孝史 ヤスカワ タカシ

Research Projects

Research Products

Co-Researchers

アルツハイマー病の新規治療薬の開発に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of NRBP1-Ubiquitin Ligase Inhibitors for the Creation of Novel Alzheimer's Disease TherapeuticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research for the development of therapeutic drugs for Alzheimer's disease targeting a novel ubiquitin ligasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of target genes of transcription elongation factor Elongin A and analysis of its regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of transcription factor Elongin A with E3 activity in mouse neural developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of mammalian transcription elongation factor Elongin A in mouse neural developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detailed characterization of Humanin, a newly identified anti-Alzheimer's disease peptide and potential starting point for development of the first curative therapy for Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病遺伝子が誘導する神経細胞死抑制因子受容体の同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional properties of Mammalian elongin A and its role in stress response.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Degradation of p21^<Cip1> through APC/ C^<Cdc20> mediated ubiquitylation is inhibited by cyclin dependent kinase 2 in cardiomyocytes2011

Author(s)

Journal Title

Data Source

[Patent] 認知症治療薬のスクリーニング方法2019

Inventor(s)

Yasukawa Takashi 安川孝史

YASUKAWA Takashi 安川孝史

安川孝史ヤスカワタカシ