FUJIMOTO Masao 藤本正男

… Alternative Names

藤本正男フジモトマサオ

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Researcher Number	60295805
External Links
Affiliation (based on the past Project Information) *help	2013: 奈良県立医科大学, 医学科, 講師 2007: 奈良県立医科大学, 医学部, 講師 2005: Nara Medical University, Faculty of Medicine, Lecturer, 医学部, 講師 2003 – 2005: 奈良県立医科大学, 医学部, 助手
Review Section/Research Field	Except Principal Investigator Gastroenterology
Keywords	Except Principal Investigator エンドトキシン / TNF-α / 急性肝不全 / Toll-like受容体 / Toll-like receptor / 非アルコール性脂肪肝炎 / 自然免疫 / アルコール性肝障害 / Kupffer細胞 / マクロファージ … More / innate immunity / nonalcoholic steatohepatitis / macrophage / Kupffer cell / Tumor necrosis factor-α / acute hepatic failure / endotoxin / 肝障害 / 多臓器不全 / ウルソデオキシコール酸 / 難吸収性抗菌薬 / 腸管相関 / Kupffer 細胞 / Toll-like 受容体 / ガラクトサミン / TLR4アンタゴニスト / Toll-like受容体(TLR)4 / 非アルコール性脂肪肝炎(NASH) Less

Gut-liver axis mediated by endotoxin and innate immunity
- Principal Investigator
  
  FUKUI HIROSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nara Medical University
マクロファージと肝障害:Toll-like受容体制御による新規治療の探索
- Principal Investigator
  
  FUKUI Hiroshi, 福井博
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nara Medical University
Multiple organ failure and macrophage function in severe liver injury: Toll-like receptor and endotoxin clearance
- Principal Investigator
  
  FUKUI Hiroshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nara Medical University

All 2013 2012 2011 2009 2008 2007 2003 2002 Other

All Journal Article Presentation Book

[Book] アルコール性肝障害と炎症性サイトカイン2013
- Author(s)
  瓦谷英人,辻本達寛,守屋圭,高谷広章,堂原彰敏,美登路昭,吉治仁志,藤本正男,福井博
- Publisher
  エンドトキシン・自然免疫研究
- Data Source
  KAKENHI-PROJECT-23590987
[Book] 急性肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態新規治療法の可能性を含めて2013
- Author(s)
  高谷広章,植村正人,藤本正男,松山友美,森岡千恵,石川昌利,辻本達寛,瓦谷英人,北澤利幸,早川正樹,松本雅則,藤村吉博,福井博
- Publisher
  エンドトキシン・自然免疫研究
- Data Source
  KAKENHI-PROJECT-23590987
[Book] 血中エンドトキシン測定の展望Endotoxin Activity Assay(EAA)2011
- Author(s)
  藤本正男,福井博
- Publisher
  エンドトキシン・自然免疫研究
- Data Source
  KAKENHI-PROJECT-23590987
[Book] アルコール性肝障害の病態と自然免疫機構2011
- Author(s)
  瓦谷英人,辻本達寛,北澤利幸,藤本正男,植村正人,福井博
- Publisher
  エンドトキシン・自然免疫研究
- Data Source
  KAKENHI-PROJECT-23590987
[Book] 肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態2011
- Author(s)
  高谷広章,植村正人,藤本正男,松山友美,森岡千恵,石川昌利,辻本達寛,瓦谷英人,松本雅則,藤村吉博,福井博
- Publisher
  エンドトキシン・自然免疫研究
- Data Source
  KAKENHI-PROJECT-23590987
[Book] 消化器内科領域におけるEndotoxin Activity Assay(EAA)の有用性についての検討2011
- Author(s)
  藤本正男,武山真也,北澤利幸,辻本達寛,瓦谷英人,植村正人,福井博
- Publisher
  エンドトキシン血症救命治療研究会誌
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] 急性肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態　新規治療法の可能性を含めて2013
- Author(s)
  高谷広章, 植村正人, 藤本正男, 松山友美, 森岡千恵, 石川昌利, 辻本達寛, 瓦谷英人, 北澤利幸, 早川正樹, 松本雅則, 藤村吉博, 福井博
- Journal Title
  
  エンドトキシン・自然免疫研究
  
  Volume: 16 Pages: 16-20
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] The effect of inflammatory cytokines in alcoholic liver disease2013
- Author(s)
  Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2013 Pages: 495156-495156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] The effect of inflammatory cytokines in alcoholic liver disease. Mediators2013
- Author(s)
  Kawaratani, H. Tsujimoto, T. Douhara, A. Takaya, H. Moriya, K. Namisaki, T. Noguchi, R. Yoshiji, H. Fujimoto, M. Fukui, H.
- Journal Title
  
  Mediators Inflamm
  
  Volume: 2013 Pages: 495156-495156
- DOI
  10.1155/2013/495156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] アルコール性肝障害と炎症性サイトカイン2013
- Author(s)
  瓦谷英人, 辻本達寛, 守屋圭, 高谷広章, 堂原彰敏, 美登路昭, 吉治仁志, 藤本正男, 福井博
- Journal Title
  
  エンドトキシン・自然免疫研究
  
  Volume: 16 Pages: 12-15
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score2012
- Author(s)
  Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H, Toyohara M, Kurumatani N, Fukui H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 42 Pages: 459-72
- NAID
  10031144260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] 消化器内科領域におけるEndotoxin Activity Assay(EAA)の有用性についての検討2011
- Author(s)
  藤本正男,武山真也,北澤利幸,辻本達寛,瓦谷英人,植村正人,福井博
- Journal Title
  
  エンドトキシン血症救命治療研究会誌
  
  Volume: 15 Pages: 69-73
- Data Source
  KAKENHI-PROJECT-23590987
[Journal Article] Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138.2009
- Author(s)
  Tsujimoto T, Kawaratani H, Kitazawa T, Yoshiji H, Fujimoto M, Uemura M, Fukui H.
- Journal Title
  
  World J Gastroenterol 15
  
  Pages: 5533-40
- Data Source
  KAKENHI-PROJECT-19590784
[Journal Article] Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure.2008
- Author(s)
  Kitazawa T, Tsujimoto T, Kawaratani H, Fujimoto M, Fukui H
- Journal Title
  
  J Gastroenterol Hepatol 23
- Data Source
  KAKENHI-PROJECT-19590784
[Journal Article] 急性アルコール投与ラットにおける各種マクロファージのTNF-α産生能におよぼすEP4受容体アゴニストの影響2003
- Author(s)
  中谷吉宏, 北澤利幸, 藤本正男, 田村信宏, 植村正人, 山尾純一, 福井博
- Journal Title
  
  アルコールと医学生物学 23
  
  Pages: 98-104
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590678
[Journal Article] Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis.2002
- Author(s)
  Nakatanl Y, Fukui H, Kltazawa T, Fujimoto M, Yamao J, Uemura M
- Journal Title
  
  Alcohol Clin Exp Res 26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590678
[Journal Article] Effect of alcohol on the secretion of tumor necrosis factor-alpha by macrophages in the presence of rat serum.2002
- Author(s)
  Nakatani Y, Fukui H, Kitazawa T, Fujimoto M, Yamao J, Uemura M
- Journal Title
  
  Alcohol Clin Exp Res 26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590678
[Journal Article] 急性アルコール投与ラットにおける各種マクロファージのTNF-α産生能.2002
- Author(s)
  北澤利幸, 中谷吉宏, 藤本正男, 田村信宏, 植村正人, 福井博
- Journal Title
  
  アルコールと医学生物学 22
  
  Pages: 39-41
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590678
[Presentation] 肝障害をめぐる腸肝相関DSS腸炎モデルとNASHモデルの対比2013
- Author(s)
  瓦谷英人,守屋圭,高谷広章,堂原彰敏,辻本達寛,吉治仁志,藤本正男,植村正人,福井博
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] 肝障害をめぐる腸肝相関　DSS腸炎モデルとNASHモデルの対比2013
- Author(s)
  瓦谷英人, 守屋圭, 高谷広章, 堂原彰敏, 辻本達寛, 吉治仁志, 藤本正男, 植村正人, 福井博
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] Expression of TLR4 and TNF-a in the rat dextran sulfate sodium(DSS) induced colitis model2012
- Author(s)
  K awaratani H, Moriya K, Takaya H, Douhara A, Yoshiji H, Fujimoto M, Uemura M, Fukui H.
- Organizer
  IEIIS2012
- Place of Presentation
  東京
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] Endotoxin activity as a novel marker reflecting decompensation in patients with liver cirrhosis2012
- Author(s)
  Fujimoto M, Uemura M, Takaya H, Takeyama S, Fukui H.
- Organizer
  IEIIS2012
- Place of Presentation
  東京
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] Potential role of endotoxemia on the decreased activity of plasma ADAMTS13 in patients with chronic and acute hepatic failure2012
- Author(s)
  Takaya H, Uemura M, Fujimoto M, Matsuyama T, Morioka C, Ishikawa M, Kawaratani H, Matsumoto M, Fujimura Y, Fukui H.
- Organizer
  IEIIS2012
- Place of Presentation
  東京
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] 非アルコール性脂肪肝炎における造影超音波検査と肝病態との関連2009
- Author(s)
  藤本正男, 植村正人, 山尾純一, 吉治仁志, 辻本達寛, 北澤利幸, 北出光輝, 瓦谷英人, 福井博
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] 非アルコール性脂肪性肝炎における自然免疫;クッパー細胞機能と新しい診断と治療への応用2009
- Author(s)
  辻本達寛, 瓦谷英人, 北澤利幸, 吉治仁志, 藤本正男, 植村正人, 福井博
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] クッパー細胞機能異常からみた非アルコール性脂肪性肝炎(NASH)の病態2009
- Author(s)
  辻本達寛, 瓦谷英人, 北澤利幸, 藤本正男, 平井都始子, 福井博
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] ラットNASHモデルにおける造影超音波造影能とクッパー細胞機能2008
- Author(s)
  辻本達寛, 瓦谷英人, 北澤利幸, 吉治仁志, 藤本正男, 平井都始子, 植村正人, 福井博
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] サイトカイン産生調節薬Y-40138のNASHモデルに対する効果:新しい免疫的治療法の可能性2008
- Author(s)
  辻本達寛, 瓦谷英人, 北澤利幸, 山崎正晴, 吉治仁志, 藤本正男, 植村正人, 福井博
- Organizer
  第50回日本消化器病学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] Endotoxin and acute liver failure: New therapeutic approach by regulation of macrophage innate immunity2008
- Author(s)
  Fukui H, Kitazawa T, Tsujimoto T, Kawaratani H, Hoppou K, Kitano H, Nakatani Y, Fujimoto M
- Organizer
  UEGW
- Place of Presentation
  Vienna
- Year and Date
  2008-10-21
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] Kupffer cell dysfunction in the rat non-alcoholic steatohepatitis (NASH) model.2007
- Author(s)
  Tsujimoto T, Kawaratani H, Kitazawa T, Yoshiji H, Fujimoto M, Hirai T, Uemura M, Fukui H
- Organizer
  Asian Pacific Digestive Week
- Place of Presentation
  Kobe
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] ラットNASHモデルにおける肝内TNF-α産生2007
- Author(s)
  辻本達寛, 瓦谷英人, 北澤利幸, 吉治仁志, 藤本正男, 平井都始子, 植村正人, 福井博
- Organizer
  第11回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590784
[Presentation] Potential role of endotoxemia on the decreased activity of plasma ADAMTS13 in patients with chronic and acute hepatic failure
- Author(s)
  Takaya H, Uemura M, Fujimoto M, Matsuyama T, Morioka C, Ishikawa M, Kawaratani H, Matsumoto M, Fujimura Y, Fukui H
- Organizer
  【IEIIS2012】Homeostatic Inflammation Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] Expression of TLR4 and TNF-α in the rat dextran sulfate sodium(DSS) induced colitis model
- Author(s)
  Kawaratani H, Moriya K, Takaya H, Douhara A, Yoshiji H, Fujimoto M, Uemura M, Fukui H
- Organizer
  【IEIIS2012】Homeostatic Inflammation Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590987
[Presentation] Endotoxin activity as a novel marker reflecting decompensation in patients with liver cirrhosis
- Author(s)
  Fujimoto M, Uemura M, Takaya H, Takeyama S, Fukui H
- Organizer
  【IEIIS2012】Homeostatic Inflammation Symposium
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590987

1. FUKUI Hiroshi (80145838)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
2. YOSHIJI Hitoshi (40336855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. MITORO Akira (10382285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 辻本達寛 (00423921)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. NAMISAKI Tadashi (20526850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 福井博 (80145383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KITAZAWA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. KAWARATANI Hideto

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

FUJIMOTO Masao 藤本 正男

藤本 正男 フジモト マサオ

Research Projects

Research Products

Co-Researchers

Gut-liver axis mediated by endotoxin and innate immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージと肝障害:Toll-like受容体制御による新規治療の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multiple organ failure and macrophage function in severe liver injury: Toll-like receptor and endotoxin clearance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アルコール性肝障害と炎症性サイトカイン2013

Author(s)

Publisher

Data Source

[Book] 急性肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態新規治療法の可能性を含めて2013

Author(s)

Publisher

Data Source

[Book] 血中エンドトキシン測定の展望Endotoxin Activity Assay(EAA)2011

Author(s)

Publisher

Data Source

[Book] アルコール性肝障害の病態と自然免疫機構2011

Author(s)

Publisher

Data Source

[Book] 肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態2011

Author(s)

Publisher

Data Source

[Book] 消化器内科領域におけるEndotoxin Activity Assay(EAA)の有用性についての検討2011

Author(s)

Publisher

Data Source

[Journal Article] 急性肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態 新規治療法の可能性を含めて2013

Author(s)

Journal Title

Data Source

[Journal Article] The effect of inflammatory cytokines in alcoholic liver disease2013

Author(s)

Journal Title

Data Source

[Journal Article] The effect of inflammatory cytokines in alcoholic liver disease. Mediators2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルコール性肝障害と炎症性サイトカイン2013

Author(s)

Journal Title

Data Source

[Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 消化器内科領域におけるEndotoxin Activity Assay(EAA)の有用性についての検討2011

Author(s)

Journal Title

Data Source

[Journal Article] Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138.2009

Author(s)

Journal Title

Data Source

[Journal Article] Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure.2008

Author(s)

Journal Title

FUJIMOTO Masao 藤本正男

藤本正男フジモトマサオ

[Journal Article] 急性肝不全における血漿エンドトキシン濃度とADAMTS13活性の動態　新規治療法の可能性を含めて2013

[Presentation] 肝障害をめぐる腸肝相関　DSS腸炎モデルとNASHモデルの対比2013