Karashima Takashi 辛島尚

… Alternative Names

辛島尚カラシマタカシ

KARASHIMA Takashi 辛島尚

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Researcher Number	60304672
Other IDs
Affiliation (Current)	2025: 高知大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 高知大学, 教育研究部医療学系臨床医学部門, 准教授 2017 – 2020: 高知大学, 教育研究部医療学系臨床医学部門, 准教授 2015 – 2016: 高知大学, 教育研究部医療学系臨床医学部門, 講師 2015: 高知大学, 医学部泌尿器科学教室, 講師 2013 – 2014: 高知大学, 教育研究部医療学系, 講師 … More 2012 – 2013: 高知大学, 教育研究部医療学系, 助教 2009 – 2011: Kochi University, 教育研究部・医療学系, 助教 2010: 高知大学, 教育研究部医療学系, 助教 2007: Kochi University, 医学部, 助教 2005 – 2006: Kochi Medical School, Research Associate, 医学部, 助手 2003 – 2005: 高知大学, 医学部附属病院, 助手 2002: 高知医科大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Urology / Basic Section 56030:Urology-related / Urology Except Principal Investigator Urology / Human pathology
Keywords	Principal Investigator 腎癌 / 腎細胞癌 / 骨転移 / 免疫不全 / 腎癌骨転移 / VHL / 破骨細胞 / クロマチン / VHL遺伝子 / セカンド/サードヒット遺伝子 … More / セカンド/サードヒット遺伝子変異 / CRISPR/Cas9 / PBRM1 / イミキモド / 腎がん / チロシンキナーゼ阻害剤 / 免疫療法 / 乳頭状腎癌 / 細胞接着因子 / 癌胎児性抗体 / 癌胎児性抗原 / ラミニンα1 / VHL遺伝子変異 / フォンヒッペルリンドウ遺伝子 / 血管内皮増殖因子 / MMP / IL-8 / bFGF / VEGF / 血管新生 … More Except Principal Investigator 腎細胞癌 / HIG2 / HOXB13 / VHL遺伝子 / 癌 / 腫瘍学 / ラミニン / 腎盂尿管癌 / 尿中腫瘍マーカー / トランスレーショナルリサーチ / 細胞外マトリックス / 膀胱がん / 治療奏効 / 診断 / バイオマーカー / TFE3 / ALK / 転座型 / Autocline / Methylation / VHL / Hypoxia Inducible Factor / VEGF / MIRC9 / ヒト腎細胞癌 / 遺伝子メチル化 / 癌抑制遺伝子 / transitional cell carcinoma / metastasis-related gene / DNA methylation / 転移 / 浸潤 / 膀胱移行上皮癌 / E-cadherin / 移行上皮癌 / 転移関連遺伝子 / メチル化 / DNA / VHLノックアウトマウス / HIF2a / HIF1a / von Hippel-Lindau病 / 腎癌 / ES細胞 / HIF2α / HIF1α / VHL遺伝子変異 / AT1受容体阻害剤(ARB) / 発現制御 / ATI受容体阻害剤(ARB) / 分子標的治療薬 / AT1受容体拮抗剤(ARB) Less

Mechanism of kidney cancer development via immunodeficiency due to germline mutation of chromatin regulatorPrincipal Investigator
- Principal Investigator
  
  辛島尚
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kochi University
Second-hit gene mutations for developing renal cell carcinoma in VHL diseasePrincipal Investigator
- Principal Investigator
  
  Karashima Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kochi University
Development of laminin-gamma2 monomer as a potent biomarker for upper urinary tract cancer
- Principal Investigator
  
  SHUIN Taro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
転座型腎細胞癌の分子標的療法に向けた病理診断法の確立
- Principal Investigator
  
  KURODA Naoto
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kochi University
Novel combination therapy with imiquimod and tyrosine kinase inhibitor against renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KARASHIMA Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Development of a novel diagnostic method for bladder cancer
- Principal Investigator
  
  Koshikawa Naohiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanagawa Cancer Center Research Institute
  The University of Tokyo
The role of pCAM, papillary renal cell carcinoma-related factor for developing novel molecular pathologic classification and differentiation-inducing therapyPrincipal Investigator
- Principal Investigator
  
  KARASHIMA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Analyses of altered VHL protein function in the clear cell renal carcinoma(CRCC) and its utilization for CRCC patients.
- Principal Investigator
  
  SHUIN TARO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Lamininα1, Novel cancer embryonal antigen of renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  KARASHIMA Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Search for process of proliferation by the ARB of renal cell carcinoma
- Principal Investigator
  
  FUKATA Satoshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Kochi University
フォンヒッペルリンドウ遺伝子が関与する腎細胞癌骨転移特異的遺伝子発現の解析Principal Investigator
- Principal Investigator
  
  辛島尚
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Kochi University
破骨前駆細胞を標的とした腎細胞癌骨転移に対する新規治療の確立Principal Investigator
- Principal Investigator
  
  辛島尚
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Basic Strategy for the treatment of kidney cancer : identification and clinical utilization of new tumor suppressor genes or oncogenes closely correlated with VHL gene VHL
- Principal Investigator
  
  SHUIN Taro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kochi University
Novel Therapeutic Strategy Based on Systematic Regulation of Metastasis-related Genes Expression in Human Transitional Cell Carcinoma of the Urinary Bladder
- Principal Investigator
  
  INOUE Keiji
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kochi University
  高知大学(医学部)
腎細胞癌の骨転移メカニズムの解明および新規抗骨転移関連因子療法の開発Principal Investigator
- Principal Investigator
  
  辛島尚
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  高知大学(医学部)

All 2017 2016 2015 2013 2007 2005 Other

All Journal Article Presentation Patent

[Journal Article] Therapy with transcutaneous administration of imiquimod combined with oral administration of sorafenib suppresses renal cell carcinoma growing in an orthotopic mouse model2017
- Author(s)
  Karashima Takashi、Udaka Keiko、Niimura Mayumi、Suzuki Katsuhide、Osakabe Hiroto、Shimamoto Tsutomu、Fukata Satoshi、Inoue Keiji、Kuroda Naoto、Seiki Motoharu、Shuin Taro
- Journal Title
  
  Oncology Letters
  
  Volume: 14 Issue: 1 Pages: 1162-1166
- DOI
  10.3892/ol.2017.6235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-15K10593
[Journal Article] Urinary laminin-γ2 is a novel biomarker of non-muscle invasive urothelial　carcinoma.2015
- Author(s)
  Kamada M, Koshikawa N, Minegishi T, Kawada C, Karashima T, Shuin T, & Seiki M.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 12 Pages: 1730-7
- DOI
  10.1111/cas.12832
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462471
[Journal Article] Expression of angiogenesis-related gene profiles and development of resistance to tyrosine-kinase inhibitor in advanced renal cell carcinoma: characterization of sorafenib-resistant cells derived from a cutaneous metastasis.2013
- Author(s)
  Karashima T, Fukuhara H, Tamura K, Ashida S, Kamada M, Inoue K, Taguchi T, Kuroda N, Shuin T.
- Journal Title
  
  International Jounal of Urology
  
  Volume: Sep;20(9) Issue: 9 Pages: 923-930
- DOI
  10.1111/iju.12084
- NAID
  10031195895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592396
[Journal Article] Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.2007
- Author(s)
  Karashima T
- Journal Title
  
  Int J Oncol 30(4)
  
  Pages: 937-945
- Data Source
  KAKENHI-PROJECT-18791122
[Journal Article] Effect of combination therapy with a novel bisphosphonate, minodronate (YM529), and docetaxel on a model of bone metastasis by human transitional cell carcinoma.2005
- Author(s)
  Inoue K, Karashima T, Fukata S, Nomura A, Kawada C, Kurabayashi A, Furihata M, Ohtsuki Y, Shuin T
- Journal Title
  
  Clin Cancer Res (Sep 15) 11(18)
  
  Pages: 6669-6677
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591692
[Journal Article] Blockade of Anti-Vanscular Endothelial Growth Factor-Receptor 2 Pathway Inhibits Growth of Human Renal Cell Carcinoma, RBM1-IT4, in the Kidney but not in the Bone of Nude Mice.
- Author(s)
  Takashi Karashima
- Journal Title
  
  Int J Oncology (印刷中)
- Data Source
  KAKENHI-PROJECT-16790917
[Patent] 腎細胞がん治療剤2016
- Inventor(s)
  辛島　尚
- Industrial Property Rights Holder
  辛島　尚
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-001595
- Filing Date
  2016-04-19
- Data Source
  KAKENHI-PROJECT-15K10593
[Presentation] 腎癌にたいするイミダゾキノリン誘導体とチロシンキナーゼ阻害剤の新規併用療法2015
- Author(s)
  辛島尚　宇高恵子　新村真由美　川田千明　鎌田雅行　井上啓史　黒田直人　執印太郎
- Organizer
  第103回日本泌尿器科学会総会
- Place of Presentation
  石川県立音楽堂他（金沢市）
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-15K10593
[Presentation] 腎癌にたいするイミキモドとチロシンキナーゼ阻害剤の新規併用療法2015
- Author(s)
  辛島尚、宇高恵子、新村真由美、川田千明、井上啓史、黒田直人、清木元治、執印太郎、
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  国立京都国際会館他（京都市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15K10593

1. SHUIN Taro (70128601)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
2. INOUE Keiji (00294827)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. TAMURA Kenji (50464384)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAMADA Masayuki (90304683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SHUIN Taro (80179019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KURODA Naoto (60291457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 津田雅之 (90406182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. FUKATA Satoshi (80527599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ASHIDA Shingo (80380327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SOGAWA Kazuhiro (80175421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAKINUMA Yoshihiko (40233944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ASO Teijiro (20291289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Koshikawa Naohiko (70334282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 奥田平和 (60325420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宇高恵子 (40263066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Karashima Takashi 辛島 尚

辛島 尚 カラシマ タカシ

KARASHIMA Takashi 辛島 尚

Research Projects

Research Products

Co-Researchers

Mechanism of kidney cancer development via immunodeficiency due to germline mutation of chromatin regulatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Second-hit gene mutations for developing renal cell carcinoma in VHL diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of laminin-gamma2 monomer as a potent biomarker for upper urinary tract cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転座型腎細胞癌の分子標的療法に向けた病理診断法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel combination therapy with imiquimod and tyrosine kinase inhibitor against renal cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel diagnostic method for bladder cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of pCAM, papillary renal cell carcinoma-related factor for developing novel molecular pathologic classification and differentiation-inducing therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of altered VHL protein function in the clear cell renal carcinoma(CRCC) and its utilization for CRCC patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lamininα1, Novel cancer embryonal antigen of renal cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for process of proliferation by the ARB of renal cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

フォンヒッペルリンドウ遺伝子が関与する腎細胞癌骨転移特異的遺伝子発現の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

破骨前駆細胞を標的とした腎細胞癌骨転移に対する新規治療の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Strategy for the treatment of kidney cancer : identification and clinical utilization of new tumor suppressor genes or oncogenes closely correlated with VHL gene VHL

Principal Investigator

Karashima Takashi 辛島尚

辛島尚カラシマタカシ

KARASHIMA Takashi 辛島尚

[Journal Article] Urinary laminin-γ2 is a novel biomarker of non-muscle invasive urothelial　carcinoma.2015