YOSHIMURA Kazuhisa 吉村和久

… Alternative Names

吉村和久ヨシムラカズヒサ

Less

Researcher Number	60315306
Affiliation (Current)	2024: 東京都健康安全研究センター, 企画調整部, 所長
Affiliation (based on the past Project Information) *help	2013 – 2014: 国立感染症研究所, その他部局等, その他 2012 – 2014: 国立感染症研究所, エイズ研究センター, 室長 2010 – 2011: Kumamoto University, エイズ学研究センター, 准教授 2008 – 2009: Kumamoto University, エイズ学研究センター, 講師 2000 – 2004: 熊本大学, エイズ学研究センター, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Infectious disease medicine / 内科学一般 Except Principal Investigator Virology
Keywords	Principal Investigator HIV-1 / proviral DNA / turnover / HAART / CD4^+ T cell / residual replication / gp120 / 中和抗体 / animal model / antiretroviral therapy … More / Turnover / NBD誘導体 / Envelope / subtype non-B / 侵入阻害剤 / CD4 mimic / envelope / Betulinic acid / entry inhibitors / エンベロープ / 中和抗体増強剤 / NBD-556 / 低分子化合物 / memory CD8+ T cell / SHIV89.6P / memory CD8^+ T cells / SHIV_<89.6P> / リンパ球ターンオーバー / 経口投与 / マカクサルモデル / SHIV / 臨床応用 / 新規耐性変異 / 多剤耐性ウイルス / UIC-94003 / プロテアーゼ阻害剤 … More Except Principal Investigator リガンド / 2量体化 / 補助受容体 / オリゴマー形成 / HIV / モノマー / オリゴマー / CCR5 / HIV-1 Less

Development of novel entry inhibitors with inducing conformational change of Non-B HIV-1 envelope.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Institute of Infectious Diseases
The role of CCR5 oligomerization in the entry of CCR5-using HIV-1
- Principal Investigator
  
  MAEDA Yosuke
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kumamoto University
Analysis for a mechanism of anti-HIV-1 neutralizing antibody enhancement by a novel low molecular weight compound.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Evaluation of residual viral replication by proviral DNA level and T cell turnover for optimization of HAART.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
新規抗HIV剤の開発と薬剤耐性のメカニズムの解析Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University

All 2015 2014 2013 2012 2011 2010 2009 2008 2003 2002 Other

All Journal Article Presentation

[Journal Article] Passive transfer of neutralizing monoclonal antibody KD-247reduces plasma viral load in patients chronically infected with HIV-1.2015
- Author(s)
  Matsushita, S., Yoshimura, K., Ramirez, K.P., Pisupati, J., Murakami, T.
- Journal Title
  
  AIDS
  
  Volume: 29 Issue: 4 Pages: 453-462
- DOI
  10.1097/qad.0000000000000570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Virology
  
  Volume: 475 Pages: 187-203
- DOI
  10.1016/j.virol.2014.11.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-26430091
[Journal Article] Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.2015
- Author(s)
  Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G.,Chiang, L.A., Pan Y., Moran, J.L., Marchand, B.,Singh, K., Gallazzi, F., Quinn, T.P., Yoshimura, K., Murakami, T., Matsushita S., Sarafianos, S.G.
- Journal Title
  
  The FASEB Journal
  
  Volume: 29 Issue: 1 Pages: 1-11
- DOI
  10.1096/fj.14-252262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014
- Author(s)
  Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, Yoko Kawanami, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 8 Pages: 1816-1826
- DOI
  10.1099/vir.0.062885-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013
- Author(s)
  Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T., Igarashi, T., Matsuhita, S., Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 24 Pages: 7884-7889
- DOI
  10.1016/j.bmc.2013.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24105507, KAKENHI-PUBLICLY-24119506, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107, KAKENHI-PROJECT-25410171
[Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013
- Author(s)
  Shigeyoshi Harada, Kazuhisa Yoshimura, Aki Yamaguchi, Samatchaya Boonchawalit, Keisuke Yusa, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 94 Issue: 5 Pages: 933-943
- DOI
  10.1099/vir.0.047167-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.2013
- Author(s)
  Kuwata T
- Journal Title
  
  J Virol.
  
  Volume: in press Issue: 10 Pages: 933-943
- DOI
  10.1128/jvi.00201-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PUBLICLY-25115519
[Journal Article] CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.2013
- Author(s)
  Narumi, T., Arai, H., Yoshimura, K., Harada, S., Hirota, Y., Ohashi, N., Hashimoto, C.. Nomura, W., Matsushita, S. and Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 8 Issue: 9 Pages: 2518-2526
- DOI
  10.1016/j.bmc.2013.02.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05127, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
[Journal Article] Generation of a replication-competent simianhuman immunodeficiency virus, the neutralisation sensitivity of which can be enhanced in the presence of a small molecule CD4 mimic.2013
- Author(s)
  Otsuki, H., Hishiki, T., Miura, T., Hashimoto, C., Narumi, T., Tamamura, H., Yoshimura, K., Matsushita, S., and Igarashi, T.
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 94 Issue: 12 Pages: 2710-2716
- DOI
  10.1099/vir.0.055590-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658240, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
[Journal Article] Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail.2013
- Author(s)
  8. Kuwata, T.
- Journal Title
  
  Frontiers in Microbiology/Virology.
  
  Volume: 4 Pages: 1-7
- DOI
  10.3389/fmicb.2013.00117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Structural Dynamics of HIV-1 Envelope Gp120 Outer Domain with V3 Loop.2012
- Author(s)
  Yokoyama M, Naganawa S, Yoshimura K, Matsushita S, Sato H
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591485
[Journal Article] Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop.2012
- Author(s)
  Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG
- Journal Title
  
  Cellular and Molecular Biology
  
  Volume: 58 Pages: 71-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591485
[Journal Article] In vitro and In vivo Resistance to Human Immunodeficiency Virus Type 1 Entry Inhibitors2011
- Author(s)
  Maeda, Y.
- Journal Title
  
  J AIDS Clinic Res
  
  Volume: in press Issue: S2
- DOI
  10.4172/2155-6113.s2-004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163, KAKENHI-PROJECT-23590548
[Journal Article] CD4 mimics targeting the mechanism of HIV entry.2010
- Author(s)
  Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 20
  
  Pages: 354-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2.2010
- Author(s)
  Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita, S.
- Journal Title
  
  J Gen Virol 91
  
  Pages: 1335-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.2010
- Author(s)
  Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita, S.
- Journal Title
  
  J Virol 84
  
  Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.2010
- Author(s)
  Yoshimura, K.
- Journal Title
  
  J.Virol.
  
  Volume: 84 Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] CD4mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.2010
- Author(s)
  Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka, T., Nomura, W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 20
  
  Pages: 5853-5858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Non-cleavage site gag mutations in amprenavir-resistant HIV-1 predispose HIV-1 to rapid acquisition of amprenavir resistance but delays development of resistance to other protease Inhibitors.2009
- Author(s)
  Aoki, M., Venzon, D.J., Koh, Y., Aoki-Ogata, H., Miyakawa, T., Yoshimura, K., Maeda, K., Mitsuya, H.
- Journal Title
  
  J Virol. 83
  
  Pages: 3059-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection the intracellular trafficking and stability of HIV-1 Gag.2008
- Author(s)
  Ryo, A., Tsurutani, N., Ohba, K., Kimura, R., Komano, J., Nishi, M., Soeda, H., Hattori, S., Perrem, K., Yamamoto, M., Chiba, J., Mimaya, J., Yoshimura, K., Matsushita, S., Honda, M., Yoshimura, A., Sawasaki, T., Aoki, I., Morikawa, Y., Yamamoto, N.
- Journal Title
  
  Proc Natl Acad Sci USA. 105
  
  Pages: 294-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV89.6P.2003
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol.Methods. 112
  
  Pages: 121-128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A potent protease inhibitor(PI) UIC-94003 interacting with main chains of HIV protease active site amino acids and the development of a novel mutation A28S in the protease of UIC-94003-resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol. 78
  
  Pages: 12030-12040
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A Potent Protease Inhibitor (PI) UIC-94003 Interacting with Main Chains of HIV Protease Active Site Amino Acids and the Development of a Novel Mutation A28S in the Protease of UIC-94003-Resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol 76
  
  Pages: 1349-1358
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A Potent Protease Inhibitor (PI) UIC-94003 Interacting with Main Chains of HIV Protease Active Site Amino Acids and the Development of a Novel Mutation A28S in the Protease of UIC-94003-Resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol. 76
  
  Pages: 1349-1358
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Presentation] Impact of CD4 mimetics-resistant mutations on susceptibilities to anti-Env nMAbs.2014
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura
- Organizer
  21th Conference on Retroviruses and Opportunistic Infections (CROI2014)
- Place of Presentation
  Boston (USA)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] 抗V3抗体および低分子CD4ミミック曝露後投与によるアカゲザルでのSHIV複製抑制2013
- Author(s)
  大附寛幸,丸田泰広,橋本智恵,鳴海哲夫,廣田雄樹, 原田恵嘉, 三浦智行, 吉村和久,玉村啓和,松下修三, 五十嵐樹彦
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] CD4 mimic small compounds, NBD-556 and its analogues bind at three amino acid positions in the gp120 CD4 cavity.2013
- Author(s)
  Harada S, Boonchawalit S, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI 2013)
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Analysis of interaction between gp120 and CD4 mimic small compounds that enhance the activity of anti-HIV neutralizing antibodies.2013
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Shuzo Matsushita, Kazuhisa Yoshimura
- Organizer
  AIDS Vaccine 2013
- Place of Presentation
  Barcelona (Spain)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Impact of Maraviroc-resistant and low CCR5-adapted mutations induced in vitro passage on sensitivity to anti-Env neutralizing antibodies.2013
- Author(s)
  Yoshimura K, Harada S, Boonchawalit S, and Matsushita S
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI 2013)
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導2013
- Author(s)
  原田恵嘉, 鳴海哲夫, Samatchaya Boonchawalit, 玉村啓和, 松下修三, 吉村和久
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013
- Author(s)
  原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Indole-type small CD4 mimic molecules targeting an HIV envelope protein gp120.2013
- Author(s)
  Yuki Hirota, Tetsuo Narumi, Kazuhisa Yoshimura, Shigeyoshi Harada, Chie Hashimoto, Wataru Nomura, Tatsuhiko Igarashi, Shuzo Matsushita, Hirokazu Tamamura
- Organizer
  14th Kumamoto AIDS Seminar
- Place of Presentation
  Kumamoto (Japan)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] HIV外被タンパク質gp120を標的とするインドール型低分子CD4ミミックの創製研究2012
- Author(s)
  廣田雄樹、鳴海哲夫、橋本智恵、吉村和久、原田恵嘉、大附寛幸、三浦智行、五十嵐樹彦、相川春夫、野村渉、松下修三、玉村啓和
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro induction of ten CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012
- Author(s)
  Harada S, Arai H, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  19th International AIDS Conference
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] R5臨床分離株を用いた10種のCD4類似低分子化合物に対するin vitro 耐性ウイルス誘導2012
- Author(s)
  原田恵嘉、新井　啓之、鳴海　哲夫、玉村　啓和、松下修三、吉村和久
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] CCR5阻害剤による耐性変異と中和抗体感受性2012
- Author(s)
  吉村和久
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する2012
- Author(s)
  桑田岳夫、吉村和久、松下修三
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro induction of twelve CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012
- Author(s)
  Harada S, Boonchawalit S, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  13th Kumamoto AIDS Seminar GCOE Joint International Symposium,
- Place of Presentation
  Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] R5臨床分離株を用いたCD4類似低分子化合物誘導体に対するin vitro耐性ウイルス誘導2012
- Author(s)
  原田恵嘉、鳴海　哲夫、玉村　啓和、松下修三、吉村和久
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in vitro selection of Maraviroc.2010
- Author(s)
  Yoshimura K., Harada S., Matsushita S.
- Organizer
  17h Conference on Retroviruses and Opportunistic Infections (CROI 2010)
- Place of Presentation
  Moscone Center West, San Francisco, USA.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Evolution and selection of the env gene of HIV-1 primary isolates during in vitro selection of raltegravir.2010
- Author(s)
  Harada S., Hamji A., Matsushita S., Yoshimura K.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in vitro selection of Maraviroc2010
- Author(s)
  吉村和久
- Organizer
  17h Conference on Retroviruses and Opportunistic Infections(CROI 2010)
- Place of Presentation
  Moscone Center West, San Francisco, USA
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Impact of a point mutation in V2 (L175P) in neutralization resistance mediated by functional trimer formation of Env.2010
- Author(s)
  Liu M., Shibata J., Harada S., Takehisa J., Yoshimura K., Matsushita S.
- Organizer
  AIDS Vaccine 2010
- Place of Presentation
  The Omni Hotel at CNN Center, Atlanta, USA.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro selections of raltegravir resistant variants using diverse primary isolates, subtype B, C, CRFO1_AE, and CRFO8_BC.2010
- Author(s)
  Harada S., Yoshimura K., Kawanami Y., Matsushita S.
- Organizer
  2010 IYIS
- Place of Presentation
  The Center for AIDS Research, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] CD4 mimetic compound-mediated enhancement of the neutralization activities of anti-V3 and CD4i monoclonal antibodies against the standard panel of primary isolates.2010
- Author(s)
  Matsushita S., Mouri S., Harada S., Yamada Y., Tamamura H., Yoshimura K.
- Organizer
  XVIII International AIDS conference
- Place of Presentation
  The Reed Messe Wien, Vienna, Austria.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region under pressure of a potent neutralizing antibody in vitro.2009
- Author(s)
  Matsushita S., Narahara C., Nishida Y., Honda A., Harada S., Yoshimura K.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in V4 and C4 regions of the HIV-1 CRF-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors.2009
- Author(s)
  Yoshimura, K.
- Organizer
  16th Conference on Trtroviruses and Opportunistic Infections (CROI 2009)
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc.2009
- Author(s)
  Yoshimura K., Harada S., Hatada M., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in gp120 of R5 HIV-1 laboratory isolate induced by the in vitro selection of maraviroc confer highly sensitive to anti-V3 monoclonal antibody.2009
- Author(s)
  Ishikawa T., Yoshimura K., Hatada M., Harada S., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Generation of an integrase inhibitor raltegravir resistant variants using recent primary isolates, X4, R5 and dual/mix HIV-1.2009
- Author(s)
  Harada S., Yoshimura K., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in V4 and C4 regions of the HIV-1 CRFO8-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors.2009
- Author(s)
  Yoshimura K., Harada S., Hatada M., Matsushita S.
- Organizer
  16th Conference on Retroviruses and Opportunistic Infections (CROI 2009)
- Place of Presentation
  Palais des Congres de Montreal, Montreal, Canada.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc2009
- Author(s)
  吉村和久
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko kumamoto, Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] ケモカインレセプター阻害剤の臨床的研究～臨床分離株を用いたマラビロック耐性誘導～2009
- Author(s)
  吉村和久
- Organizer
  第23回日本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] A primary R5 isolate undergoes different escape pathway during in vitro selection with low or high concentration of an anti-V3 monoclonal antibody.2009
- Author(s)
  Narahara C., Hatada M., Harada S., Yoshimura K., Matsushita S.
- Organizer
  AIDS Vaccine 2009 Conference
- Place of Presentation
  Marriott Rive Gauche Conference Center, Paris, France.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5.2009
- Author(s)
  Yoshimura K., Matsushita S.
- Organizer
  Kumamoto AIDS Seminar GCOE Joint InternationalSymposium-Satellite Symposium
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization.2009
- Author(s)
  Matsushita S., Narahara C., Morizono M., Nishida Y., Honda-Shibata A., Harada S., Yoshimura, K.
- Organizer
  5th Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  The Cape Town International Convention Centre, Cape Town, South Africa.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Different mutation in HIV-1 gp120 V3-tip region for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection with low or high concentration of the Mab.2008
- Author(s)
  Narahara C., Yoshimura K., Hatada M., Harada S., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] CD4 mimic small compound のin vitro耐性誘導による結合部位の予測2008
- Author(s)
  吉村和久
- Organizer
  第22回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] The impact of an N-linked glycosylation site insertion in HIV-1 gp120 region to escape from a potent neutralization anti-V3 monoclonal antibody.2008
- Author(s)
  Hatada M., Yoshimura K., Ishikawa T., Harada S., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of human immunodeficiency virus type 1 variants resistant to a low-molecular CD4 mimic compound.2008
- Author(s)
  Yoshimura K., Hatada M., Harada S., Shibata J., Masuno H., Tamamura H., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound.2008
- Author(s)
  Yoshimura, K.
- Organizer
  9^<th> Kumamoto AIDS Seminar.
- Place of Presentation
  Kumamoto
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Impact of Maraviroc (MVC)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  20th International AIDS Conference
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2014-07-20 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Resistance Profile of CD4 Mimic Small Compounds (CD4MCs) and the Structure Analysis by Molecular Dynamic (MD) Simulation.
- Author(s)
  Shigeyoshi Harada, Masaru Yokoyama, Samatchaya Boonchawalit, Hironori Sato, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  HIV Research For Prevention (HIVR4P) 2014
- Place of Presentation
  Cape Town (South Africa)
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Mutations at the bottom of the Phe43 cavity are responsible for cross-resistance to NBD analogues.
- Author(s)
  Shigeyoshi Harada, Yu Irahara, Samatchaya Boonchawalit, Mai Goryo, Hirokazu Tamamura, Tetsuro Matano, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections (CROI) 2015
- Place of Presentation
  Seattle (USA)
- Year and Date
  2015-02-23 – 2015-02-26
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Impact of the Drug-Escaped HIV Envelope Mutations on Susceptibility to Neutralizing Antibodies.
- Author(s)
  Kazuhisa Yoshimura.
- Organizer
  17th International Conference on Emerging Infectious Diseases (EID), AIDS Panel Meeting
- Place of Presentation
  Taipei (Taiwan)
- Year and Date
  2015-01-28 – 2015-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-24591485

1. MAEDA Yosuke (30284764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HARADA Shinji (60173085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松下修三 (00199788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. NARUMI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HARADA Shigeyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. KUWATA Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 三浦智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIMURA Kazuhisa 吉村 和久

吉村 和久 ヨシムラ カズヒサ

Research Projects

Research Products

Co-Researchers

Development of novel entry inhibitors with inducing conformational change of Non-B HIV-1 envelope.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of CCR5 oligomerization in the entry of CCR5-using HIV-1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for a mechanism of anti-HIV-1 neutralizing antibody enhancement by a novel low molecular weight compound.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of residual viral replication by proviral DNA level and T cell turnover for optimization of HAART.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規抗HIV剤の開発と薬剤耐性のメカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Passive transfer of neutralizing monoclonal antibody KD-247reduces plasma viral load in patients chronically infected with HIV-1.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013

Author(s)

YOSHIMURA Kazuhisa 吉村和久

吉村和久ヨシムラカズヒサ