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MINOGUCHI Shigeru  箕口 滋

ORCIDConnect your ORCID iD *help
Researcher Number 60322757
Affiliation (based on the past Project Information) *help 2007 – 2009: 東京大学, 医科学研究所, 助教
2003 – 2006: 東京大学, 医科学研究所, 助手
2001 – 2002: 九州大学, 生体防御医学研究所, 助手
2000: Kurume University Institute of Life Science Assistant Professor, 分子生命科学研究所, 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / 幹細胞生物学 / Developmental biology
Except Principal Investigator
Biological Sciences / Virology / Pediatrics / Functional biochemistry
Keywords
Principal Investigator
MSCV / DNAメチル化 / ES細胞 / YY-1 / Brm / 幹細胞 / Brm遺伝子 / SNF複合体 / SWI / レトロウイルスベクター … More / MLV / DNA methylation / retrovirus vector / gene therapy / ES cells / stem cells / YY1 / ポリコーム遺伝子 / 組織幹細胞 / レトロウイルスべクター / 遺伝子治療 / position effect variegation / エピジェネティクス / ジーンサイレンシング / レトロウイルス / BRG1遺伝子 / クロマチン / 細胞分化 / 原始外胚葉 / 自己複製 / 多能性幹細胞 / アクチン / p21 / イメージング / 1分子 / FRET / GFP / JAK / 細胞内局在 / EGF受容体 / 一分子観察 / 蛍光顕微鏡 / Raf / Ras / サイトカイン / チロシンキナーゼ … More
Except Principal Investigator
JAK / STAT / サイトカイン / CIS / tyrosine kinase / SWI / SOCS / チロシンキナーゼ / チロシンりん酸化 / siRNA / MLV / HIV / ノックアウトマウス / tyrosine phosphorylation / cytokine / c-Cbl / インターフェロン / レンチウイルス / レトロウイルス / SNF複合体 / キナーゼ抑制因子 / 炎症 / MAPキナーゼ / Ras / ジーンサイレンシング / クロマチン構造変換因子 / Brm遺伝子 / レトロウイルスベクター / 遺伝子治療 / latent infection / reactivation / gene silencing / splicing / SNF complex / epigenetics / 後転写制御 / ヒストンメチル化 / プロテオミクス / 転写後制御 / RNA編集 / p54nrb / 潜伏感染 / 再活性化 / ジンサイレンシング / スプライシング / エピジェネティクス / ubiquitin ligase / leukemia / SOCS1 / JAB / oncogene / TEL / interferon / hepayoma / hepatitis / tyrosine phsphorylation / inflammation / シグナル伝達 / 細胞膜 / Raf / EGF受容体 / FGF受容体 / HPV / ユビキチン化 / MITF / 肝がん / 肝炎 / kinase inhibitor / knockout mice / 胎児造血 / エリスロポエチン / GFP遺伝子 / ウイルスベクター / NFI-B / miR-21 / shRNA / in situ hybridization / feedback 制御 / 大腸癌 / RNA干渉 / NF-I / プロモーター / microRNA / レンチウイルスベクター / Decoy RNA / Requiem / AP-1 / NFkB / miRNA / SNFクロマチン構造変換因子 / NFkappaB / Brm / 足場非依存的な増殖 / requiem / RelB / コクサッキーウイルス / アデノウイルス / 関節リウマチ / 炎症性疾患 / 大腸炎 / 関節炎リウマチ / 造血因子 / 脂質ラフト / 好酸球 / 消化管神経 / チロシンキナ一ゼ / patched遺伝子 / 再生治療 / ジーンサイレンシンク / ヒストンアセチル化 / 癌抑制遺伝子 / 再生医療 Less
  • Research Projects

    (11 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (20 People)
  •  Development of new types of retrovirus vectors that modulate epigenetical regulation.

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  ゲノムDNAメチル化動態を制御する分子機構の解明Principal Investigator

    • Principal Investigator
      箕口 滋
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      The University of Tokyo
  •  Elucidation of host-retrovirus interaction by analyzing chromatin dynamics

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      The University of Tokyo
  •  クロマチン構造変換因子SWI/SNFによる幹細胞の自己複製制御Principal Investigator

    • Principal Investigator
      箕口 滋
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of Retrovirus Vectors Permissive in Tissue Stem CellsPrincipal Investigator

    • Principal Investigator
      MINOGUCHI Shigeru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      幹細胞生物学
    • Research Institution
      The University of Tokyo
  •  癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系

    • Principal Investigator
      IBA Hideo
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  サイトカインのシグナル制御機構とその破綻

    • Principal Investigator
      吉村 昭彦
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Kyushu University
  •  Mechanism of Regulation of Tyrosine Kinase Signaling

    • Principal Investigator
      YOSHIMURA Akihiko
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
      Kurume University
  •  Suppressopm of growth of leukemia cells by a tyrosine kinase inhibitor JAB

    • Principal Investigator
      KATO Reiko, 神薗 慎太郎
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kurume University
  •  サイトカインシグナル伝達経路の可視化Principal Investigator

    • Principal Investigator
      箕口 滋, 安川 秀雄
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (B)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
      Kurume University
  •  Physiological function and Molecular mechanism of regulation by the CIS/JAB family members

    • Principal Investigator
      YOSHIMURA Akihkio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional biochemistry
    • Research Institution
      Kurume University

All 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Instability of retroviral DNA methylation in embryonic stem cells2008

    • Author(s)
      Minoguchi,S. and Iba, H.
    • Journal Title

      Stein Cells 26

      Pages: 1166-1173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba, H.
    • Journal Title

      J. Mol. Biol 378

      Pages: 492-504

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Instability of retroviral DNA methylation in embryonic stem cells.2008

    • Author(s)
      Minoguchi, S. and Iba, H.
    • Journal Title

      Stem Cells (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism2008

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamarnichi, N., Sakurai, K., and Iba, H.
    • Journal Title

      J.Mol.Biol. 378

      Pages: 492-504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Instability of retroviral DNA methylation in embryonic stem cells.2008

    • Author(s)
      Minoguchi S, Iba, H.
    • Journal Title

      Stem Cells 26

      Pages: 1166-1173

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K. and Iba, H.
    • Journal Title

      J. Mol. Biol. (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007

    • Author(s)
      Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba, H.
    • Journal Title

      FEBS Letter 581

      Pages: 4949-4954

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] RNA-dependent transcriptional silencing does not contribute to retroviral gene silencing in human cells.2007

    • Author(s)
      Haraguchi, T., Mizutani, T., Yamamichi, N., Ito, T., Minoguchi, S., and Iba, H.
    • Journal Title

      FEBS Letter 581

      Pages: 4949-4954

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines.2006

    • Author(s)
      Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H.
    • Journal Title

      Oncogene 25

      Pages: 470-479

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Journal Article] The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits anti-oncogenic potential.2005

    • Author(s)
      Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba, H.
    • Journal Title

      Oncogene 24

      Pages: 5471-5481

    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism2007

    • Author(s)
      Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamanichi, N., Iba, H.
    • Organizer
      Systems Biology: Global Regulation of Gene Expression 2007 April
    • Place of Presentation
      New York
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism Systems Biology2007

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Iba H.
    • Organizer
      Global Regulation of Gene Expression
    • Place of Presentation
      New York, USA
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] The Novel Role of Dnmt3L in Maintenance of DNA Methylation-Dependent Retroviral Gene Silencing2007

    • Author(s)
      箕口滋、伊庭英夫
    • Organizer
      理化学研究所発生再生科学総合研究センターCDB Symposium 2007
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] 幹細胞におけるDNAメチル化の動態制御機構2007

    • Author(s)
      箕口滋
    • Organizer
      熊本大学発生医学研究センター21世紀COEリエゾンラボ研究会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] AP-1 triggers the sustained transcription of miR-21 through an evolutionarily conserved feedback mechanism2007

    • Author(s)
      Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
    • Organizer
      The 11th German-Japanese Cancer Workshop
    • Place of Presentation
      京都
    • Year and Date
      2007-11-30
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] Reversible switching of MSCV Proviral Expression Reflects Dynamics of DNA Methylation in Embryonic Stem Cells2005

    • Author(s)
      箕口滋、渡部博貴、水谷壮利、伊庭英夫
    • Organizer
      文部科学省特定領域研究「幹細胞の可塑性と未分化性維持機構」国際シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17016015
  • [Presentation] ES細胞に感染したレトロウイルスに見られるDNAメチル化に依存した可逆的ジーンサイレンシング2005

    • Author(s)
      箕口滋、渡部博貴、水谷壮利、伊庭英夫
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-17016015
  • 1.  YOSHIMURA Akihkio (90182815)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  IBA Hideo (60111449)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  WAKIOKA Toru (40330873)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  ITO Taiji (60343109)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 5.  MIZUTANI Taketoshi (00376617)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 6.  KATO Reiko (00333469)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  安川 秀雄 (60289361)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  神薗 慎太郎 (30261077)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  大坪 素秋 (10211799)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  HARAGUCHI Takeshi (10549455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  YAMAMICHI Nobutake (30463897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 12.  KAI Hisashi (60281531)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ISOBE Yoshiaki (70106607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  岸原 健二 (80214774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  松崎 吾郎 (30229455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  加藤 裕久 (30080724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MATSUMOTO Akira
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  JAMES Ihle
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  IHLE James
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  伊庭 英生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 16 results

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