MINOGUCHI Shigeru 箕口滋

Researcher Number	60322757
Affiliation (based on the past Project Information) *help	2007 – 2009: 東京大学, 医科学研究所, 助教 2003 – 2006: 東京大学, 医科学研究所, 助手 2001 – 2002: 九州大学, 生体防御医学研究所, 助手 2000: Kurume University Institute of Life Science Assistant Professor, 分子生命科学研究所, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / 幹細胞生物学 / Developmental biology Except Principal Investigator Biological Sciences / Virology / Pediatrics / Functional biochemistry
Keywords	Principal Investigator MSCV / DNAメチル化 / ES細胞 / YY-1 / Brm / 幹細胞 / Brm遺伝子 / SNF複合体 / SWI / レトロウイルスベクター … More / MLV / DNA methylation / retrovirus vector / gene therapy / ES cells / stem cells / YY1 / ポリコーム遺伝子 / 組織幹細胞 / レトロウイルスべクター / 遺伝子治療 / position effect variegation / エピジェネティクス / ジーンサイレンシング / レトロウイルス / BRG1遺伝子 / クロマチン / 細胞分化 / 原始外胚葉 / 自己複製 / 多能性幹細胞 / アクチン / p21 / イメージング / 1分子 / FRET / GFP / JAK / 細胞内局在 / EGF受容体 / 一分子観察 / 蛍光顕微鏡 / Raf / Ras / サイトカイン / チロシンキナーゼ … More Except Principal Investigator JAK / STAT / サイトカイン / CIS / tyrosine kinase / SWI / SOCS / チロシンキナーゼ / チロシンりん酸化 / siRNA / MLV / HIV / ノックアウトマウス / tyrosine phosphorylation / cytokine / c-Cbl / インターフェロン / レンチウイルス / レトロウイルス / SNF複合体 / キナーゼ抑制因子 / 炎症 / MAPキナーゼ / Ras / ジーンサイレンシング / クロマチン構造変換因子 / Brm遺伝子 / レトロウイルスベクター / 遺伝子治療 / latent infection / reactivation / gene silencing / splicing / SNF complex / epigenetics / 後転写制御 / ヒストンメチル化 / プロテオミクス / 転写後制御 / RNA編集 / p54nrb / 潜伏感染 / 再活性化 / ジンサイレンシング / スプライシング / エピジェネティクス / ubiquitin ligase / leukemia / SOCS1 / JAB / oncogene / TEL / interferon / hepayoma / hepatitis / tyrosine phsphorylation / inflammation / シグナル伝達 / 細胞膜 / Raf / EGF受容体 / FGF受容体 / HPV / ユビキチン化 / MITF / 肝がん / 肝炎 / kinase inhibitor / knockout mice / 胎児造血 / エリスロポエチン / GFP遺伝子 / ウイルスベクター / NFI-B / miR-21 / shRNA / in situ hybridization / feedback 制御 / 大腸癌 / RNA干渉 / NF-I / プロモーター / microRNA / レンチウイルスベクター / Decoy RNA / Requiem / AP-1 / NFkB / miRNA / SNFクロマチン構造変換因子 / NFkappaB / Brm / 足場非依存的な増殖 / requiem / RelB / コクサッキーウイルス / アデノウイルス / 関節リウマチ / 炎症性疾患 / 大腸炎 / 関節炎リウマチ / 造血因子 / 脂質ラフト / 好酸球 / 消化管神経 / チロシンキナ一ゼ / patched遺伝子 / 再生治療 / ジーンサイレンシンク / ヒストンアセチル化 / 癌抑制遺伝子 / 再生医療 Less

Development of new types of retrovirus vectors that modulate epigenetical regulation.
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ゲノムDNAメチル化動態を制御する分子機構の解明Principal Investigator
- Principal Investigator
  
  箕口滋
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  The University of Tokyo
Elucidation of host-retrovirus interaction by analyzing chromatin dynamics
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
クロマチン構造変換因子SWI/SNFによる幹細胞の自己複製制御Principal Investigator
- Principal Investigator
  
  箕口滋
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of Retrovirus Vectors Permissive in Tissue Stem CellsPrincipal Investigator
- Principal Investigator
  
  MINOGUCHI Shigeru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  幹細胞生物学
- Research Institution
  The University of Tokyo
癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サイトカインのシグナル制御機構とその破綻
- Principal Investigator
  
  吉村昭彦
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Kyushu University
Mechanism of Regulation of Tyrosine Kinase Signaling
- Principal Investigator
  
  YOSHIMURA Akihiko
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Kurume University
Suppressopm of growth of leukemia cells by a tyrosine kinase inhibitor JAB
- Principal Investigator
  
  KATO Reiko, 神薗慎太郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
サイトカインシグナル伝達経路の可視化Principal Investigator
- Principal Investigator
  
  箕口滋, 安川秀雄
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Kurume University
Physiological function and Molecular mechanism of regulation by the CIS/JAB family members
- Principal Investigator
  
  YOSHIMURA Akihkio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Kurume University

All 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Instability of retroviral DNA methylation in embryonic stem cells2008
- Author(s)
  Minoguchi,S. and Iba, H.
- Journal Title
  
  Stein Cells 26
  
  Pages: 1166-1173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba, H.
- Journal Title
  
  J. Mol. Biol 378
  
  Pages: 492-504
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Instability of retroviral DNA methylation in embryonic stem cells.2008
- Author(s)
  Minoguchi, S. and Iba, H.
- Journal Title
  
  Stem Cells (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism2008
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamarnichi, N., Sakurai, K., and Iba, H.
- Journal Title
  
  J.Mol.Biol. 378
  
  Pages: 492-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Instability of retroviral DNA methylation in embryonic stem cells.2008
- Author(s)
  Minoguchi S, Iba, H.
- Journal Title
  
  Stem Cells 26
  
  Pages: 1166-1173
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K. and Iba, H.
- Journal Title
  
  J. Mol. Biol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007
- Author(s)
  Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] RNA-dependent transcriptional silencing does not contribute to retroviral gene silencing in human cells.2007
- Author(s)
  Haraguchi, T., Mizutani, T., Yamamichi, N., Ito, T., Minoguchi, S., and Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines.2006
- Author(s)
  Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H.
- Journal Title
  
  Oncogene 25
  
  Pages: 470-479
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits anti-oncogenic potential.2005
- Author(s)
  Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba, H.
- Journal Title
  
  Oncogene 24
  
  Pages: 5471-5481
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism2007
- Author(s)
  Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamanichi, N., Iba, H.
- Organizer
  Systems Biology: Global Regulation of Gene Expression 2007 April
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] AP-1 triggered transcription of miR-21 through an evolutionally conserved mechanism Systems Biology2007
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Iba H.
- Organizer
  Global Regulation of Gene Expression
- Place of Presentation
  New York, USA
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] The Novel Role of Dnmt3L in Maintenance of DNA Methylation-Dependent Retroviral Gene Silencing2007
- Author(s)
  箕口滋、伊庭英夫
- Organizer
  理化学研究所発生再生科学総合研究センターCDB Symposium 2007
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] 幹細胞におけるDNAメチル化の動態制御機構2007
- Author(s)
  箕口滋
- Organizer
  熊本大学発生医学研究センター21世紀COEリエゾンラボ研究会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] AP-1 triggers the sustained transcription of miR-21 through an evolutionarily conserved feedback mechanism2007
- Author(s)
  Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K, Iba H.
- Organizer
  The 11th German-Japanese Cancer Workshop
- Place of Presentation
  京都
- Year and Date
  2007-11-30
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Reversible switching of MSCV Proviral Expression Reflects Dynamics of DNA Methylation in Embryonic Stem Cells2005
- Author(s)
  箕口滋、渡部博貴、水谷壮利、伊庭英夫
- Organizer
  文部科学省特定領域研究「幹細胞の可塑性と未分化性維持機構」国際シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] ES細胞に感染したレトロウイルスに見られるDNAメチル化に依存した可逆的ジーンサイレンシング2005
- Author(s)
  箕口滋、渡部博貴、水谷壮利、伊庭英夫
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17016015

1. YOSHIMURA Akihkio (90182815)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. IBA Hideo (60111449)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. WAKIOKA Toru (40330873)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. ITO Taiji (60343109)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. MIZUTANI Taketoshi (00376617)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
6. KATO Reiko (00333469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安川秀雄 (60289361)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 神薗慎太郎 (30261077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 大坪素秋 (10211799)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HARAGUCHI Takeshi (10549455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. YAMAMICHI Nobutake (30463897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. KAI Hisashi (60281531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISOBE Yoshiaki (70106607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岸原健二 (80214774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松崎吾郎 (30229455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 加藤裕久 (30080724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MATSUMOTO Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. JAMES Ihle

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. IHLE James

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 伊庭英生

# of Collaborated Projects: 0 results

# of Collaborated Products: 16 results

MINOGUCHI Shigeru 箕口 滋

Research Projects

Research Products

Co-Researchers

Development of new types of retrovirus vectors that modulate epigenetical regulation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノムDNAメチル化動態を制御する分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of host-retrovirus interaction by analyzing chromatin dynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

クロマチン構造変換因子SWI/SNFによる幹細胞の自己複製制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Retrovirus Vectors Permissive in Tissue Stem CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌抑制遺伝子を長期間高レベルで発現する新規レトロウイルスベクターとその産生系

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

サイトカインのシグナル制御機構とその破綻

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mechanism of Regulation of Tyrosine Kinase Signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppressopm of growth of leukemia cells by a tyrosine kinase inhibitor JAB

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サイトカインシグナル伝達経路の可視化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological function and Molecular mechanism of regulation by the CIS/JAB family members

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Instability of retroviral DNA methylation in embryonic stem cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Mir-21 gene expression triggered by AP-1 is sustained through a double negative feedback mechanism.2008

Author(s)

Journal Title

Data Source

[Journal Article] Instability of retroviral DNA methylation in embryonic stem cells.2008

Author(s)

Journal Title

MINOGUCHI Shigeru 箕口滋