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TACHIBANA Isao  立花 功

ORCIDConnect your ORCID iD *help
Researcher Number 60324761
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2012: 大阪大学, 医学(系)研究科(研究院), 准教授
2012: 大阪大学, 大学院・医学系研究科, 講師
2011: 大阪大学, 医学(系)研究科(研究院), 講師
2011: 大阪大学, 医学研究科, 講師
2010 – 2011: 大阪大学, 医学系・研究科, 講師
2008 – 2010: Osaka University, 医学系研究科, 講師
2002 – 2004: Osaka University, Department of Molecular Medicine, Assistant Professor, 医学系研究科, 助手
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Respiratory organ internal medicine
Except Principal Investigator
Respiratory organ internal medicine / Respiratory organ internal medicine / General internal medicine (including Psychosomatic medicine)
Keywords
Principal Investigator
CD100 / マクロファージ / テトラスパニン / tolerance / Th2 response / airway hyperreactivity / allergic airway inflammation / gene targeting / semaphorin / 気道過敏症 … More / 免疫寛容 / Th2反応 / 気道過敏性 / アレルギー性気道炎症 / ノックアウトマウス / Sema4D / セマフォリン / ラフト / CD14 / スタチン / COPD / 炎症 / LPS / CD9 / 閉塞性肺疾患 … More
Except Principal Investigator
CD9 / 肺癌 / テトラスパニン / CD151 / cell adhesion / cell motility / metastasis / integrin / tetraspanin / lung cancer / 細胞接着 / 細胞運動 / 転移 / インテグリン / herpes virus thymidine kinase / adenoviral vector / double-infection / Cre recombinase / carcinoembryonic antigen / cancer-specific therapy / gene therapy / ヘルペスウイルス・チミジンキナーゼ / ヘルペスウィルス・チミジンキナーゼ / アデノウィルスベクター / Cre リコンビナーゼ / 癌胎児性抗原 / ヘルペスウイルスチミジンキナーゼ / アデノウイルスベクター / 二重感染法 / Creリコンビナーゼ / 癌特異的治療 / 遺伝子治療 / 炎症性サイトカイン / CD9/CD81 DKOマウス / サルコペニア / 老年医学 / 間質性肺炎 / 上皮細胞 / 肺線維症 / インテグリン、CD9 / 特発性肺線維症 / リンパ管新生 / 血管新生 Less
  • Research Projects

    (8 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (11 People)
  •  テトラスパニンに作用するCOPD治療薬の探索Principal Investigator

    • Principal Investigator
      立花 功
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  The establishment of animal model for sarcopenia and clarification of the mechanism of sarcopenia: An investigation using an animal model for chronic obstructive pulmonary diseases

    • Principal Investigator
      RAKUGI Hiromi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Osaka University
  •  Functional analysis of tetraspanins(CD9, CD151) in lung fibrosis

    • Principal Investigator
      TAKEDA Yoshito
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Mechanisms of lung inflammation in tetraspanin-knockout micePrincipal Investigator

    • Principal Investigator
      TACHIBANA Isao
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Role or tetraspanins in angiogenesis and lymphangiogenesis

    • Principal Investigator
      TAKAHASHI Ryo, KAWASE Ichiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Expression of tetraspanins in human lung cancer cells : frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer

    • Principal Investigator
      KAWASE Ichiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  The role of CD 100, the lymphcyte semaphorin, in the development of allergic pulmonary inflammationPrincipal Investigator

    • Principal Investigator
      TACHIBANA Isao
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Cancer-specific therapy utilizing the Cre recombinase/lox P system

    • Principal Investigator
      OSAKI Tadashi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University

All 2012 2011 2010 2009 2008 2003

All Journal Article Presentation

  • [Journal Article] Early[ 18F] fluorodeoxyglucose positron emission tomography at two days of gefitinib treatment predicts clinical outcome in patients with adenocarcinoma of the lung2012

    • Author(s)
      Takahashi R, Hirata H, Tachibana I, Shimosegawa E, Inoue A, Nagatomo I, Takeda Y, Kida H, Goya S, Kijima T, Yoshida M, Kumagai T, Kumanogoh A, Okumura M, Hatazawa J, Kawase I.
    • Journal Title

      Clin Cancer Res

      Volume: 18(1) Pages: 220-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity2012

    • Author(s)
      Kazuyuki Tsujino, Yoshito Takeda, Toru Arai, Yasushi Shintani, Ryosaku Inagaki, Hiroyuki Saiga, Takeo Iwasaki, Satoshi Tetsumoto, Yingji Jin, Shoichi Ihara, Toshiyuki Minami, Mayumi Suzuki, Izumi Nagatomo, Koji Inoue, Hiroshi Kida, Takashi Kijima, Mari Ito, Masanori Kitaichi, Yoshikazu Inoue, Isao Tachibana, Kiyoshi Takeda, Meinoshin Okumura, Martin E. Hemler, Atsushi Kumanogoh
    • Journal Title

      Am J Respir Crit Care Med

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] 4-Hydroxy-2-nonenal induces chronic obstructive pulmonary disease-like histopathologic changes in mice2012

    • Author(s)
      Takimoto T, Yoshida M, Hirata H, Kashiwa Y, Takeda Y, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420(1) Pages: 84-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Two cases of leptomeningeal metastases from lung adenocarcinoma which progressed during gefitinib therapy but responded to erlotinib2012

    • Author(s)
      Tetsumoto S, Osa A, Kijima T, Minami T, Hirata H, Takahashi R, Kuhara H, Nagatomo I, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I.
    • Journal Title

      Int J Clin Oncol

      Volume: 17(2) Pages: 155-9

    • NAID

      10030626570

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] HER2 As Therapeutic Target for Overcoming ATP-Binding Cassette Transporter-Mediated Chemoresistance in Small Cell Lung Cancer2012

    • Author(s)
      Minami T, Kijima T, Otani Y, Kohmo S, Takahashi R, Nagatomo I, Hirata H, Suzuki M, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
    • Journal Title

      Mol Cancer Ther

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy2012

    • Author(s)
      Kohmo S, Kijima T, Mori M, Minami T, Namba Y, Yano Y, Yoneda T, Takeda Y, Kitada S, Yamaguchi T, Tachibana I, Yokota S.
    • Journal Title

      Tuberculosis(Edinb)

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity : difference in metabolism as a possible mechanism2011

    • Author(s)
      Takashi Kijima, Tomohito Shimizu, Shinpei Nonen, Mitsugi Furukawa, Yasushi Otani, Toshiyuki Minami, Ryo Takahashi, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Sho Goya, Yasushi Fujio, Junichi Azuma, Isao Tachibana, Ichiro Kawase
    • Journal Title

      J Clin Oncol

      Volume: 29(19)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer2011

    • Author(s)
      Kijima T, Takeuchi K, Tetsumoto S, Shimada K, Takahashi R, Hirata H, Nagatomo I, Hoshino S, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I.
    • Journal Title

      Cancer Sci

      Volume: 102(8) Pages: 1602-4

    • NAID

      10030242650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Involvement of Endothelial Apoptosis Underlying COPD-Like Phenotype in Adiponectin-Null Mice : Implications for Therapy2011

    • Author(s)
      Nakanishi K, Takeda Y(equally first author), Tetsumoto S, Iwasaki T, Tsujino K, Kuhara H, Jin Y, Nagatomo I, Kida H, Goya S, Kijima T, Maeda N, Funahashi T, Shimomura I, Tachibana I, Kawase I.
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 183(9) Pages: 1164-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] COPDにおけるテトラスパニンの役割2010

    • Author(s)
      武田吉人、鈴木真優美、立花功
    • Journal Title

      The Lung perspective

      Volume: 18 Pages: 291-298

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] COPDにおけるテトラスパニンの役割2010

    • Author(s)
      武田吉人、鈴木真優美、立花功
    • Journal Title

      The Lung perspective

      Volume: 18 Pages: 291-298

    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] マクロファージの活性化におけるCD9(tetraspanin)の役割.2010

    • Author(s)
      立花功、鈴木真優美、武田吉人, 他
    • Journal Title

      臨床免疫・アレルギー科 53

      Pages: 214-220

    • NAID

      40017012899

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] 分子オーガナイザCD9とCD81ダブルノックアウトマウスにおける肺気腫と骨量減少2010

    • Author(s)
      立花功
    • Journal Title

      呼吸

      Volume: 29 Pages: 194-210

    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] 分子オーガナイザCD9とCD81ダブルノックアウトマウスにおける肺気腫と骨量減少2010

    • Author(s)
      立花功
    • Journal Title

      呼吸

      Volume: 29 Pages: 194-210

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] 分子オーガナイザCD9とCD81ダブルノックアウトマウスにおける肺気腫と骨量減少2010

    • Author(s)
      立花功
    • Journal Title

      呼吸 29

      Pages: 194-210

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer2010

    • Author(s)
      Kohmo S, Kijima T, Otani Y, Mori M, Minami T, Takahashi R, Nagatomo I, Takeda Y, Kida H, Goya S, Yoshida M, Kumagai T, Tachibana I, Yokota S, Kawase I.
    • Journal Title

      Cancer Res

      Volume: 70(20) Pages: 8025-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] マクロファージの活性化におけるCD9(tetraspanin)の役割2010

    • Author(s)
      立花功、鈴木真優美、武田吉人, 他
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 214-220

    • NAID

      40017012899

    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] COPDにおけるテトラスパニンの役割.2010

    • Author(s)
      武田吉人、鈴木真優美、立花功
    • Journal Title

      The Lung perspective 18

      Pages: 291-298

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] マクロファージの活性化におけるCD9(tetraspanin)の役割2010

    • Author(s)
      立花功
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 214-220

    • NAID

      40017012899

    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, Takeda Y
    • Journal Title

      J Immunol. 15

      Pages: 6485-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, et al
    • Journal Title

      J Immunol 182

      Pages: 6485-6493

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] COPDモデルとしてのテトラスパニンCD9/CD81ダブルノックアウトマウスの解析2009

    • Author(s)
      武田吉人, 立花功, 川瀬一郎
    • Journal Title

      International Review of Asthma & COPD 11

      Pages: 31-36

    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, Takeda Y et al
    • Journal Title

      J Immunol

      Volume: 182 Pages: 6485-6493

    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] COPDモデルとしてのテトラスパニンCD9/CD81ダブルノックアウトマウスの解析2009

    • Author(s)
      武田吉人, 立花功, 川瀬一郎
    • Journal Title

      International Review of Asthma & COPD 11

      Pages: 31-36

    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Mayumi Suzuki, Isao Tachibana, Yoshito Takeda, Ping He, Seigo Minami, Takeo Iwasaki, Sho Goya, Takashi Kijima, Toru Kumagai, Mitsuhiro Yoshida, Tadashi Osaki, and Ichiro Kawase
    • Journal Title

      J Immunol

      Volume: 182(10) Pages: 6485-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation.2009

    • Author(s)
      鈴木真優美, 立花功, 武田吉人, et. al.
    • Journal Title

      J Immunol 182

      Pages: 6485-6493

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590897
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, Takeda Y
    • Journal Title

      J Immunol. 15

      Pages: 6485-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590922
  • [Journal Article] 肺癌と転移抑制因子テトラスパニン2003

    • Author(s)
      立花 功
    • Journal Title

      THE LUNG perspectives 11

      Pages: 354-360

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590807
  • [Journal Article] Tetraspanins as a metastasis-suppressors in lung cancer2003

    • Author(s)
      Isao Tachibana
    • Journal Title

      THE LUNG perspectives 11

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590807
  • [Journal Article] 肺癌と転移抑制因子テトラスパニン2003

    • Author(s)
      立花 功
    • Journal Title

      The lung perspective 11・3

      Pages: 354-360

    • Data Source
      KAKENHI-PROJECT-15590807
  • [Presentation] Deletion of tetraspanin CD151 in mice spontaneously leads to pulmonary fibrosis with age through epithelial disintegrity2012

    • Author(s)
      Yoshito Takeda, Kazuyuki Tsujino, Isao Tachibana, Atsushi Kumanogoh
    • Organizer
      アメリカ胸部疾患学会
    • Place of Presentation
      サンフランシスコ米国
    • Year and Date
      2012-05-22
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Presentation] Statins improve LPS-induced lung inflammation by blockade of the mevalonate pathway-dependent down-regulation of macrophage tetraspanin CD92012

    • Author(s)
      Isao Tachibana
    • Organizer
      5th European Conference on Tetraspanins
    • Place of Presentation
      Nijmegen, the Netherlands(オランダ)
    • Data Source
      KAKENHI-PROJECT-24591130
  • [Presentation] CD151は肺胞上皮の安定化を介して肺の線維化を制御する2012

    • Author(s)
      辻野和之、武田吉人、金英姫、鉄本訓史、鈴木真優美、木田博、木島貴志、立花功、熊ノ郷淳
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-21
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Presentation] CD151 KO mice spontaneously develop lung fibrosis, hepatic fibrosis and skin fibrosis via augmented TGF-signaling2011

    • Author(s)
      Yoshito Takeda, Kazuyuki Tsujino, Isao Tachibana, Atsushi Kumanogoh
    • Organizer
      FASEB Meeting
    • Place of Presentation
      Vermont(USA)
    • Year and Date
      2011-07-22
    • Data Source
      KAKENHI-PROJECT-21590992
  • [Presentation] 肺の炎症と気腫化におけるテトラスパニンCD9/ CD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-20590922
  • [Presentation] 肺がんと肺の炎症における分子オーガナイザCD9とCD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Data Source
      KAKENHI-PROJECT-20590897
  • [Presentation] 肺がんと肺の炎症における分子オーガナイザCD9とCD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Data Source
      KAKENHI-PROJECT-20590922
  • [Presentation] 肺の炎症と気腫化におけるテトラスパニンCD9/CD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-20590897
  • [Presentation] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2008

    • Author(s)
      I sao Tachibana
    • Organizer
      FASEB summer research conference
    • Place of Presentation
      New Haven, Connect icut, USA
    • Year and Date
      2008-06-22
    • Data Source
      KAKENHI-PROJECT-20590897
  • 1.  TAKEDA Yoshito (40452388)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 25 results
  • 2.  KAWASE Ichiro (10161324)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 3.  OSAKI Tadashi (50324778)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Ryo (10546865)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  RAKUGI Hiromi (20252679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OHISHI Mirsuru (50335345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SUGIMOTO Ken (20437403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  林 清二 (70218577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YONEDA Tsutomu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  GOYA Sho
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  西野 和美
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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