Urushitani Makoto 漆谷真

… Alternative Names

URUSHITANI Makoto 漆谷真

漆谷真ウルシタニマコト

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Researcher Number	60332326
Other IDs	https://orcid.org/0000-0003-2773-9836
External Links
Affiliation (Current)	2026: 滋賀医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 滋賀医科大学, 医学部, 教授 2016 – 2017: 滋賀医科大学, 医学部, 教授 2015: 京都大学, 大学院医学研究科, 准教授 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2013 – 2014: 京都大学, 医学部, 准教授 … More 2013: 京都大学, 医系研究科, 准教授 2012: 滋賀医科大学, 学内共同利用施設等, 准教授 2009 – 2012: Shiga University of Medical Science, 分子神経科学研究センター, 准教授 2010: 滋賀医科大学, 学内共同利用施設等, 准教授 2007 – 2008: Shiga University of Medical Science, 分子神経科学研究センター, 助教 2001 – 2002: 理化学研究所, 運動系神経変性研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Neurology / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Neurology Except Principal Investigator Basic Section 58060:Clinical nursing-related / Basic Section 42020:Veterinary medical science-related / Biological Sciences / Basic Section 52020:Neurology-related … More / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 46:Neuroscience and related fields / Veterinary medical science / Clinical veterinary science / Neurology / Nerve anatomy/Neuropathology Less
Keywords	Principal Investigator 筋萎縮性側索硬化症 / 抗体 / TDP-43 / モデルマウス / 抗体療法 / ユビキチン化 / 運動ニューロン死 / SOD1 / 変異遺伝子スクリーニング / Fused in sarcoma (FUS) … More / RNA / 核酸治療 / 低分子スクリーニング / ノックインマウス / DHX30 / FUS / superoxide dismutase 1 / 細胞移植治療 / 一本鎖抗体(scFv) / 細胞間伝搬 / scFv / 再生 / オリゴデンドロサイト前駆細胞（OPC) / オリゴデンドロサイト前駆細胞 / ウイルスベクター / 移植 / 治療 / プローブ / 先制医療 / エピトープ / シグナル伝達 / 蛋白質 / 脳神経疾患 / 蛋白質分解 / 抗体医療 / 神経変性疾患 / ミスフォールドプロテイン / 筋萎縮性側索硬化症（ALS) / in vitroモデル / 免疫組織化学 / NMR解析 / 細胞モデル / 凝集体 / 高圧力NMR / 変性中間体 / 高圧NMR解析 / 神経分子病態学 / グリア細胞 / superoxide dismutase 1(SOD1) / ハイブリドーマ / ミクログリア / 免疫療法 / ワクチン / 神経病態生化学 / 結合タンパク / 運動ニューロン / 酸化ストレス / スーパーオキシドジスムターゼ / 初代培養 / CHIP / 分子シャペロン / プロテアソーム / ユビキチン … More Except Principal Investigator ALS / 筋萎縮性側索硬化症 / TDP-43 / カニクイザル / 筋萎縮性側索硬化症（ALS） / 小胞体ストレス / 遺伝子 / 神経科学 / 脳神経疾患 / 神経変性疾患 / バイオマーカー / 標的化輸送 / 分子治療法 / 細胞特異的遺伝子輸送 / 核酸医薬 / 重症度 / RNA代謝 / micro RNA / non-coding RNA / caspase 3 / Caspase3 / タンパク質切断 / DPC / 悉皆登録 / 脳卒中予後予測 / 機械学習 / 悉皆調査 / 予後予測 / 脳卒中発症登録 / 日本人一般住民 / 潜在性動脈硬化 / 疫学 / AI / MRI / 認知症 / 意思決定支援 / 生活障害 / 情動調節障害(PBA) / 非運動症状 / 情動調節障害（PBA) / 呼吸管理 / 低酸素状態 / 進行抑制 / レンチウイルス / ノックアウトサル / トランスジェニックサル / FUS遺伝子 / 低分子化合物 / protein folding / 食品機能性成分 / ミスフォールディング / 分子プローブ / 発光プローブ / ミスフォールド蛋白質 / ポリフェノール / 発光タンパク質 / diosmetin / ミスフォールドタンパク質 / 小胞体 / ホタルルシフェラーゼ / ユビキチン / in utero electroporation / オートファジー / 孤発性ALS / 子宮内エレクトロポレーション / 筋萎縮性側索硬化症(ALS) / 解剖学 / 蛋白質 / 改造学 / 神経変性 / ミスフォールド / ミクログリア / 抗体療法 / 犬 / 変性性脊髄症 / NMR / SOD / 構造解析 / モノクローナル抗体 / 免疫療法 / SOD1 / Rpt3 / トランスジェニックマウス / 神経外伝播 / プロテアソーム分解系 / VHL / Cullin-2 / micorarray / proteasome / トランスレーショナルリサーチ / 内科 / Alpha-synuclein / Lysosome / GBA / Gaucher disease / Medaka / Autophagy / Proteasome / SHSY-5Y / リン酸化ニューロフィラメンド / 外側核 / サルモデル / Cystatin C / 運動ニューロン / Betz巨細胞 / リン酸化 / 前角運動神経細胞 / サル / エクソソーム / 軸索電流 / AAV / 動物モデル Less

ALS進行抑制のための在宅呼吸管理プログラムの開発；潜在的低酸素状態への着眼
- Principal Investigator
  
  荻田美穂子
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Shiga University of Medical Science
新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発Principal Investigator
- Principal Investigator
  
  漆谷真
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
脳卒中機能予後の機械学習予測モデルと新規定因子：悉皆登録からDPC活用への提言
- Principal Investigator
  
  宮松直美
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Shiga University of Medical Science
Pathological and diagnostic significance of the N-terminal fragment of TDP-43 in ALS
- Principal Investigator
  
  守村敏史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
Exploratory research for disease-associated non-coding RNA and development of therapy with their targeted delivery in amyotrophic lateral sclerosis
- Principal Investigator
  
  寺島智也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Shiga University of Medical Science
ALSの非運動性生活障害の解明と看護支援方略の構築
- Principal Investigator
  
  金丸恭子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Kyoto Koka Women's University
ALSモデルカニクイザルを用いた超早期病態解明および治療戦略構築
- Principal Investigator
  
  等誠司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Shiga University of Medical Science
認知症予測の網羅的モデル開発のための一般集団における脳画像長期追跡疫学研究
- Principal Investigator
  
  三浦克之
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Shiga University of Medical Science
Drug discovery against ER stress by using a novel luminescence probe sensing ER environments
- Principal Investigator
  
  Morimura Toshifumi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Shiga University of Medical Science
A novel cell transplantation therapy for ALS using scFv-secreting OPCsPrincipal Investigator
- Principal Investigator
  
  Urushitani Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Shiga University of Medical Science
Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43Principal Investigator
- Principal Investigator
  
  Makoto Urushitani
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
  Kyoto University
Analysis of ALS related gene products in the mouse central nerve system
- Principal Investigator
  
  Toshifumi Morimura
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Shiga University of Medical Science
Study on pathomechanisms of canine degenerative myelopathy and preclinical trial for antibody therapy
- Principal Investigator
  
  KAMISHINA Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Gifu University
Disturbance of brain environment by impairment of proteolysis leading to neurodegeneration
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Identification of pathogenic domain in TDP-43 for ALS toward the antibody medicinePrincipal Investigator
- Principal Investigator
  
  URUSHITANI Makoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto University
  Shiga University of Medical Science
Structure analysis of mutant SOD1 and ALS immunotherapy using new monoclonal antibodies
- Principal Investigator
  
  FUJIWARA Noriko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hyogo Medical University
Brain Environment
- Principal Investigator
  
  Takahashi Ryosuke
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Development of primate model of sporadic ALS with overexpression of TDP-43
- Principal Investigator
  
  YOKOTA Takanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Medical and Dental University
A novel approach to ALS pathogenesis by investigating conformational equilibrium of TDP-43Principal Investigator
- Principal Investigator
  
  URUSHITANI Makoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Shiga University of Medical Science
Development of an immunotherapy against ALS model mice and analysis of the role of microglia in the pathogenesis of ALSPrincipal Investigator
- Principal Investigator
  
  URUSHITANI Makoto
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Shiga University of Medical Science
筋萎縮性側索硬化症における選択的運動ニューロン死の機序の分子生物学的解明Principal Investigator
- Principal Investigator
  
  漆谷真
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 脳神経内科臨床研修医ハンドブック2024
- Author(s)
  漆谷　真、山川　勇
- Total Pages
  3
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-23K24211
[Book] 脳神経内科レビュー2024-'252024
- Author(s)
  漆谷　真
- Total Pages
  5
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-23K24211
[Book] 今日の治療指針 20242024
- Author(s)
  漆谷　真
- Total Pages
  2
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23K24211
[Book] 脳神経内科レビュー2022-'232023
- Author(s)
  漆谷　真
- Total Pages
  5
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-23K24211
[Book] 今日の診療指針20232023
- Author(s)
  漆谷　真
- Total Pages
  2
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23K24211
[Book] 神経免疫　メカニズムと疾患2021
- Author(s)
  漆谷　真
- Total Pages
  201
- Publisher
  羊土社
- ISBN
  9784758103978
- Data Source
  KAKENHI-PROJECT-19H03573
[Book] 脳内環境辞典2017
- Author(s)
  漆谷　真.
- Total Pages
  156
- Publisher
  メディカルドゥ社
- ISBN
  9784944157648
- Data Source
  KAKENHI-PROJECT-26290023
[Book] 脳内環境辞典2017
- Author(s)
  高橋良輔、山中宏二、樋口真人、漆谷　真
- Total Pages
  156
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26290023
[Book] 医学のあゆみ2015
- Author(s)
  山下博史、漆谷真
- Total Pages
  70
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-ORGANIZER-23111001
[Book] レドックスUPDATE2015
- Author(s)
  玉木良高、漆谷　真
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26290023
[Book] 分子脳科学2015
- Author(s)
  山下博史, 漆谷　真.,　髙橋良輔
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-26290023
[Book] 医学のあゆみ2014
- Author(s)
  山下博史、漆谷真
- Total Pages
  10
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-ORGANIZER-23111001
[Book] MOOK別冊「細胞死研究の今－疾患との関わり、創薬に向けてのアプローチ」2013
- Author(s)
  守村敏史，高橋良輔，漆谷真
- Total Pages
  44
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PLANNED-23111002
[Book] すべてがわかる筋萎縮性側索硬化症・運動ニューロン疾患2013
- Author(s)
  漆谷　真
- Total Pages
  8
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23300131
[Book] すべてがわかる筋萎縮性側索硬化症・運動ニューロン疾患2013
- Author(s)
  漆谷　真
- Total Pages
  384
- Publisher
  中山書店
- Data Source
  KAKENHI-PLANNED-23111002
[Book] Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.2013
- Author(s)
  Urushitani M and Morimura T
- Total Pages
  24
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-ORGANIZER-23111001
[Book] ミスフォールド蛋白質による神経細胞死と治療戦略.2013
- Author(s)
  守村敏史、高橋良輔、漆谷真
- Total Pages
  44
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-ORGANIZER-23111001
[Book] Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis2013
- Author(s)
  Urushitani M
- Total Pages
  23
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-23300131
[Book] Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.2013
- Author(s)
  Urushitani M and Morimura T
- Total Pages
  23
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PLANNED-23111002
[Book] 嗜銀顆粒性認知症2013
- Author(s)
  漆谷　真
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23300131
[Book] 「ALS におけるワクチン・抗体療法の開発」アクチュアル脳・神経疾患の臨床『すべてがわかる筋萎縮性側索硬化症・運動ニューロン疾患』辻省次,祖父江元編2013
- Author(s)
  漆谷真
- Publisher
  中山書店, 東京
- Data Source
  KAKENHI-PROJECT-23300131
[Book] すべてがわかる筋委縮性側索硬化症・運動ニューロン疾患2013
- Author(s)
  漆谷真
- Total Pages
  384
- Publisher
  中山書店
- Data Source
  KAKENHI-ORGANIZER-23111001
[Book] ALSにおけるワクチン・抗体療法の開発2013
- Author(s)
  漆谷　真
- Total Pages
  7
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23300131
[Book] 認知症診療ハンドブック(宇高不可思編)2012
- Author(s)
  漆谷真
- Publisher
  医歯薬ジャーナル（印刷中）
- Data Source
  KAKENHI-PROJECT-22659171
[Book] Amyotrophic Lateral Sclerosis. In Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis, Molecular Targeted Therapy against Ed: Segawa K and Ijichi R2012
- Author(s)
  Urushitani M and Morimura T
- Publisher
  Nova Science Publishers, Inc. Hauppauge
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Pro-inflammatory microglia-targeted peptide therapy ameliorates neonatal hypoxic-ischemic encephalopathy in mice2025
- Author(s)
  Zen Rika、Tsuji Shunichiro、Maeda Tomoko、Urushitani Makoto、Murakami Takashi、Terashima Tomoya
- Journal Title
  
  Molecular Therapy
  
  Volume: 33 Issue: 7 Pages: 00176-5
- DOI
  10.1016/j.ymthe.2025.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24211, KAKENHI-PROJECT-23K07309, KAKENHI-PROJECT-24K10640, KAKENHI-PROJECT-24KJ1314
[Journal Article] Histopathological Investigation of Progressive Encephalomyelitis with Rigidity and Myoclonus: An Autopsy Case Characterized by Oculomotor Dysfunction and Autonomic Failure2025
- Author(s)
  Yabata Hiroyuki、Nakamura Ryutaro、Sugiyama Seiji、Tamaki Yoshitaka、Yamakawa Isamu、Onoda Shiori、Ishigaki Hirohito、Ikeda Toshimasa、Akagi Akio、Itoh Yasushi、Kushima Ryoji、Yoshida Mari、Iwasaki Yasushi、Urushitani Makoto
- Journal Title
  
  Intern. Med.
  
  Volume: 64 Issue: 4 Pages: 597-602
- DOI
  10.2169/internalmedicine.3741-24
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2025-02-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration2024
- Author(s)
  Hoshino Tomonori、Mukai Atsushi、Yamashita Hirofumi、Misawa Hidemi、Urushitani Makoto、Tashiro Yoshitaka、Matsuzawa Shu-ichi、Takahashi Ryosuke
- Journal Title
  
  Molecular Brain
  
  Volume: 17 Issue: 1 Pages: 77-77
- DOI
  10.1186/s13041-024-01150-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06634, KAKENHI-PROJECT-23K24211
[Journal Article] Tau beyond Tangles: DNA Damage Response and Cytoskeletal Protein Crosstalk on Neurodegeneration2024
- Author(s)
  Asada-Utsugi Megumi、Urushitani Makoto
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 14 Pages: 7906-7906
- DOI
  10.3390/ijms25147906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] Reliability study for the Japanese version of the Columbia Muscle Cramp Scale in amyotrophic lateral sclerosis2024
- Author(s)
  Sawada Masahiro、Hirayama Takehisa、Yanagihashi Masaru、Fukushima Koji、Izumi Yuishin、Naoi Tameto、Morita Mitsuya、Warita Hitoshi、Aoki Masashi、Iguchi Yohei、Katsuno Masahisa、Ogawa Nobuhiro、Urusitani Makoto、Ishihara Tomohiko、Onodera Osamu、Murakami Yoshitaka、Mitsumoto Hiroshi、Kano Osamu
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 13 Issue: 1 Pages: 14-21
- DOI
  10.1111/ncn3.12838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24211, KAKENHI-PROJECT-24K02365, KAKENHI-PROJECT-24K22096
[Journal Article] Hypermetabolism in Amyotrophic Lateral Sclerosis2024
- Author(s)
  Urushitani Makoto、Nakamura Ryutaro
- Journal Title
  
  Neurology
  
  Volume: 102 Issue: 5
- DOI
  10.1212/wnl.0000000000209179
- Open Access
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] The clinical practice guideline for the management of amyotrophic lateral sclerosis in Japan—update 20232024
- Author(s)
  Urushitani M, Warita H, Atsuta N, Izumi Y, Kano O, Shimizu T, Nakayama Y, Narita Y, Nodera H, Fujita T, Mizoguchi K, Morita M, Aoki M.
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 64 Issue: 4 Pages: 252-271
- DOI
  10.5692/clinicalneurol.cn-001946
- ISSN
  0009-918X, 1882-0654
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K03025, KAKENHI-PROJECT-23K24211, KAKENHI-PROJECT-23K24656, KAKENHI-PROJECT-22K07359
[Journal Article] Predictive Value of Midregional Pro?Atrial Natriuretic Peptide for Cardioembolic Stroke in Hyperacute Ischemic Stroke2024
- Author(s)
  Ikenouchi Hajime、Saito Satoshi、Ishiyama Hiroyuki、Kitamura Akihiro、Tanaka Tomotaka、Inoue Manabu、Takahashi Yukako、Koyama Teruhide、Kuriyama Nagato、Koga Masatoshi、Toyoda Kazunori、Urushitani Makoto、Ihara Masafumi
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 13 Issue: 11
- DOI
  10.1161/jaha.123.033134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD2023
- Author(s)
  Wada H, Hikiami R, Kusui M, Minamiyama S, Asada-Utsugi M, Shodai A, Muramatsu SI, Morimura T, Urushitani M.
- Journal Title
  
  Neuroscience Research
  
  Volume: 印刷中 Pages: 41-51
- DOI
  10.1016/j.neures.2023.02.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-23K24211
[Journal Article] Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis2023
- Author(s)
  Yabata Hiroyuki、Riku Yuichi、Miyahara Hiroaki、Akagi Akio、Sone Jun、Urushitani Makoto、Yoshida Mari、Iwasaki Yasushi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 15 Pages: 12176-12176
- DOI
  10.3390/ijms241512176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] Ideal body weight-based determination of minimum oral calories beneficial to function and survival in ALS2023
- Author(s)
  Nakamura Ryutaro、Kurihara Mika、Kobashi Shuhei、Tamaki Yoshitaka、Ogawa Nobuhiro、Kitamura Akihiro、Yamakawa Isamu、Bamba Shigeki、Terashima Tomoya、Urushitani Makoto
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 1286153-1286153
- DOI
  10.3389/fneur.2023.1286153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07413, KAKENHI-PROJECT-23K24211
[Journal Article] Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model2023
- Author(s)
  Minamiyama Sumio、Sakai Madoka、Yamaguchi Yuko、Kusui Makiko、Wada Hideki、Hikiami Ryota、Tamaki Yoshitaka、Asada-Utsugi Megumi、Shodai Akemi、Makino Akiko、Fujiwara Noriko、Ayaki Takashi、Maki Takakuni、Warita Hitoshi、Aoki Masashi、Tomonaga Keizo、Takahashi Ryosuke、Urushitani Makoto
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 28 Pages: 312-329
- DOI
  10.1016/j.omtm.2023.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06853, KAKENHI-PROJECT-21K07053, KAKENHI-PROJECT-23K24211, KAKENHI-PROJECT-20H05682, KAKENHI-PROJECT-20K07897
[Journal Article] The necessity to improve disaster preparedness among patients with amyotrophic lateral sclerosis and their families2023
- Author(s)
  Hirayama Takehisa、Shibukawa Mari、Morioka Harumi、Hozumi Masamichi、Tsuda Hiroshi、Atsuta Naoki、Izumi Yuishin、Nakayama Yuki、Shimizu Toshio、Inoue Haruhisa、Urushitani Makoto、Yamanaka Koji、Aoki Masashi、Ebihara Satoru、Takeda Atsushi、Kano Osamu
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 116 Pages: 87-92
- DOI
  10.1016/j.jocn.2023.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19760, KAKENHI-PROJECT-19H03984, KAKENHI-PROJECT-23K24211, KAKENHI-PROJECT-23K24656
[Journal Article] Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids2023
- Author(s)
  Tamaki Yoshitaka、Ross Jay P.、Alipour Paria、Castonguay Charles-?tienne、Li Boting、Catoire Helene、Rochefort Daniel、Urushitani Makoto、Takahashi Ryosuke、Sonnen Joshua A.、Stifani Stefano、Dion Patrick A.、Rouleau Guy A.
- Journal Title
  
  PLOS Genetics
  
  Volume: 19 Issue: 2 Pages: 1010606-1010606
- DOI
  10.1371/journal.pgen.1010606
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] The inhibitory effects of MIF on accumulation of canine degenerative myelopathy-associated mutant SOD1 aggregation2022
- Author(s)
  Nomura Saki、Kobatake Yui、Takashima Satoshi、Kamishina Hiroaki、Urushitani Makoto、Nishii Naohito
- Journal Title
  
  Research in Veterinary Science
  
  Volume: 147 Pages: 7-11
- DOI
  10.1016/j.rvsc.2022.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15978, KAKENHI-PROJECT-19H03573
[Journal Article] Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro2022
- Author(s)
  Asada-Utsugi Megumi、Uemura Kengo、Ayaki Takashi、T. Uemura Maiko、Minamiyama Sumio、Hikiami Ryota、Morimura Toshifumi、Shodai Akemi、Ueki Takatoshi、Takahashi Ryosuke、Kinoshita Ayae、Urushitani Makoto
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 00-00
- DOI
  10.1038/s42003-022-03312-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-19K16277
[Journal Article] Bone marrow-derived inducible microglia-like cells ameliorate motor function and survival in a mouse model of amyotrophic lateral sclerosis2022
- Author(s)
  Kobashi Shuhei、Terashima Tomoya、Katagi Miwako、Urushitani Makoto、Kojima Hideto
- Journal Title
  
  Cytotherapy
  
  Volume: 00 Issue: 8 Pages: 00-00
- DOI
  10.1016/j.jcyt.2022.02.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-21K07413
[Journal Article] Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD2022
- Author(s)
  Tamaki Yoshitaka、Urushitani Makoto
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 20 Pages: 12508-12508
- DOI
  10.3390/ijms232012508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24211
[Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022
- Author(s)
  Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
- Journal Title
  
  Scxeintific Reports
  
  Volume: 12 Issue: 1 Pages: 16030-16046
- DOI
  10.1038/s41598-022-20405-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K24211
[Journal Article] Short-Term Effect of Intensive Speech Therapy on Dysarthria in Patients With Sporadic Spinocerebellar Degeneration2021
- Author(s)
  Sonoda Yuma、Yoshida Nao、Kawami Kazunori、Kitamura Akihiro、Ogawa Nobuhiro、Yamakawa Isamu、Kim Hyoh、Sanada Mitsuru、Imai Shinji、Urushitani Makoto
- Journal Title
  
  Journal of Speech, Language, and Hearing Research
  
  Volume: 64 Issue: 3 Pages: 725-733
- DOI
  10.1044/2020_jslhr-20-00259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks2021
- Author(s)
  M. Asada-Utsugi, K. Uemura, M. Kubota, Y. Noda, Y. Tashiro, T. M. Uemura, H. Yamakado, M. Urushitani, R. Takahashi, S. Hattori, T. Miyakawa, N. Ageta-Ishihara, K. Kobayashi, M. Kinoshita, A. Kinoshita
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 23-23
- DOI
  10.1186/s13041-021-00738-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06961, KAKENHI-PROJECT-20K06852, KAKENHI-PROJECT-19K22964, KAKENHI-PUBLICLY-19H04901, KAKENHI-PROJECT-20H00663, KAKENHI-PROJECT-18H02525, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K21890, KAKENHI-PROJECT-20H03590
[Journal Article] Amelioration of motor and nonmotor symptoms in cortical cerebellar atrophy and multiple system atrophy-cerebellar type by inpatient rehabilitation2021
- Author(s)
  Sonoda Yuma、Yamanaka Yuya、Sawano Shinichiro、Komada Ryo、Kugo Masato、Kitamura Akihiro、Ogawa Nobuhiro、Yamakawa Isamu、Kim Hyoh、Sanada Mitsuru、Imai Shinji、Urushitani Makoto
- Journal Title
  
  International Journal of Rehabilitation Research
  
  Volume: Publish Ahead of Print Issue: 2 Pages: 00-00
- DOI
  10.1097/mrr.0000000000000455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1 protein in canine degenerative myelopathy2021
- Author(s)
  Nakata Kohei、Namiki Mariko、Kobatake Yui、Nishida Hidetaka、Sakai Hiroki、Yamato Osamu、Urushitani Makoto、Maeda Sadatoshi、Kamishina Hiroaki
- Journal Title
  
  Research in Veterinary Science
  
  Volume: 135 Pages: 479-485
- DOI
  10.1016/j.rvsc.2020.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Spinal Muscular Atrophy Type 3 Showing a Specific Pattern of Selective Vulnerability on Muscle Ultrasound2021
- Author(s)
  Nakamura Ryutaro、Kitamura Akihiro、Tsukamoto Takahito、Otowa Yuhei、Okamoto Naoki、Ogawa Nobuhiro、Yamakawa Isamu、Kim Hyoh、Sanada Mitsuru、Urushitani Makoto
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 12 Pages: 1935-1939
- DOI
  10.2169/internalmedicine.6396-20
- NAID
  130008052661
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-06-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] In vitro evidence of propagation of superoxide dismutase-1 protein aggregation in canine degenerative myelopathy2021
- Author(s)
  Tanaka N.、Kimura S.、Kamatari Y.O.、Nakata K.、Kobatake Y.、Inden M.、Yamato O.、Urushitani M.、Maeda S.、Kamishina H.
- Journal Title
  
  The Veterinary Journal
  
  Volume: 274 Pages: 105710-105710
- DOI
  10.1016/j.tvjl.2021.105710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-20H04285
[Journal Article] The Effect of Intravenous Methylprednisolone on Recurrent Exacerbation in Hematologic Malignancy-associated Progressive Multifocal Leukoencephalopathy2021
- Author(s)
  Nakamura Ryutaro、Kitamura Akihiro、Tsukamoto Takahito、Tamura Ryota、Ogawa Nobuhiro、Yamakawa Isamu、Kim Hyoh、Kawai Michihiro、Sanada Mitsuru、Urushitani Makoto
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 8 Pages: 1287-1291
- DOI
  10.2169/internalmedicine.5917-20
- NAID
  130008025059
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-04-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] 筋萎縮性側索硬化症プロテイノパチーの観点から2020
- Author(s)
  引網亮太, 南山素三雄, 漆谷真
- Journal Title
  
  医学のあゆみ
  
  Volume: 273 Pages: 44-49
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] 筋萎縮性側索硬化症における創薬開発の現状と展望2020
- Author(s)
  漆谷真
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 61 Pages: 81-87
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies2020
- Author(s)
  Kawamoto Yasuhiro、Ayaki Takashi、Urushitani Makoto、Ito Hidefumi、Takahashi Ryosuke
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 415 Pages: 116928-116928
- DOI
  10.1016/j.jns.2020.116928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-19H03573
[Journal Article] Transplantation of M2-deviated microglia promotes recovery of motor function after spinal cord injury in mice.2020
- Author(s)
  Kobashi S, Terashima T, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Makoto Urushitani, Hideto Kojima.
- Journal Title
  
  Molecular Therapy
  
  Volume: 28 Issue: 1 Pages: 254-265
- DOI
  10.1016/j.ymthe.2019.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07498, KAKENHI-PROJECT-17K11537, KAKENHI-PROJECT-20K09862, KAKENHI-PROJECT-19H03573
[Journal Article] Myositis with sarcoplasmic inclusions in Nakajo‐Nishimura syndrome: a genetic inflammatory myopathy2020
- Author(s)
  Takashi Ayaki、Kenya Murata、Kanazawa Nobuo、Akinori Uruha、Koichiro Ohmura、Kazuma Sugie、Shimpei Kasagi、Fangzhou Li、Megumi Mori、Nakajima Ran、Sasai Tsuneo、Nishino Ichizo、Satoshi Ueno、Makoto Urushitani、Fukumi Furukawa、Ito Hidefumi、Takahashi Ryosuke
- Journal Title
  
  Neuropathology and Applied Neurobiology
  
  Volume: 00 Issue: 6 Pages: 00-00
- DOI
  10.1111/nan.12614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K16277
[Journal Article] 筋萎縮性側索硬化症に対する創薬開発の現状と展望「神経難病をクスリで治す」．2019
- Author(s)
  漆谷真
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 7 Pages: 13-23
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] ALSにおける免疫療法開発の現状と展望．特集「ALS2019」2019
- Author(s)
  漆谷真，玉木良高，引網亮太，南山素三雄
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 7 Pages: 1289-1301
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Propofol infusion syndrome complicated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes: a case report2019
- Author(s)
  Shimizu Junji、Tabata Takahisa、Tsujita Yasuyuki、Yamane Tetsunobu、Yamamoto Yutaka、Tsukamoto Takahito、Ogawa Nobuhiro、Kim Hyou、Urushitani Makoto、Eguchi Yutaka
- Journal Title
  
  Acute Medicine & Surgery
  
  Volume: 7 Issue: 1 Pages: 00-00
- DOI
  10.1002/ams2.473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] 運動ニューロン疾患の抗体を用いた治療開発の展望2019
- Author(s)
  玉木良高，漆谷真
- Journal Title
  
  脳神経内科
  
  Volume: 90 Pages: 137-145
- Data Source
  KAKENHI-PROJECT-19H03573
[Journal Article] Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody2019
- Author(s)
  Minamiyama Sumio、Ueda Sakiho、Nakashima Ran、Yamakado Hodaka、Sakato Yusuke、Yamashita Hirofumi、Sawamoto Nobukatsu、Fujimoto Ryota、Nishino Ichizo、Urushitani Makoto、Mimori Tsuneyo、Takahashi Ryosuke
- Journal Title
  
  Muscle & Nerve
  
  Volume: 61 Issue: 1 Pages: 81-87
- DOI
  10.1002/mus.26731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03573, KAKENHI-PROJECT-20K21573, KAKENHI-PROJECT-16K09672
[Journal Article] Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals.2018
- Author(s)
  Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 6030-6030
- DOI
  10.1038/s41598-018-24463-3
- NAID
  120006482849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05705, KAKENHI-PUBLICLY-18H04564, KAKENHI-PROJECT-16H04768, KAKENHI-PROJECT-16K18383
[Journal Article] Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl2018
- Author(s)
  Hikiami Ryota、Yamakado Hodaka、Tatsumi Shinsui、Ayaki Takashi、Hashi Yuichiro、Yamashita Hirofumi、Sawamoto Nobukatsu、Tsuji Teruyuki、Urushitani Makoto、Takahashi Ryosuke
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 13 Pages: 1917-1919
- DOI
  10.2169/internalmedicine.0285-17
- NAID
  130007387154
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-16K18383, KAKENHI-PROJECT-16K09672
[Journal Article] Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy2018
- Author(s)
  Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
- Journal Title
  
  Stem Cell Rep
  
  Volume: 10 Issue: 2 Pages: 356-365
- DOI
  10.1016/j.stemcr.2017.12.001
- NAID
  120006414715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04266, KAKENHI-PROJECT-16K18383
[Journal Article] Charcot-Marie-Tooth disease type 2A with an autosomal recessive inheritance; the first report of an adult-onset disease.2017
- Author(s)
  Hikiami R, Yamashita H, Koita N, Jingami N, Sawamoto N, Furukawa K, Kawai H, Terashima T, Oka N, Hashiguchi A, Takashima H, Urushitani M, and Takahashi
- Journal Title
  
  J Hum Genet
  
  Volume: 63 Issue: 1 Pages: 89-92
- DOI
  10.1038/s10038-017-0353-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290023
[Journal Article] Multiple proteinopathies in familial ALS cases with optineurin mutation.2017
- Author(s)
  Ayaki T, Ito H, Komure O, Kamada M, Nakamura M, Wate R, Kusaka H, Yamaguchi Y, Li F, Kawakami H, Urushitani M, Takahashi R
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 77 Issue: 2 Pages: 128-138
- DOI
  10.1093/jnen/nlx109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-16K15481, KAKENHI-PROJECT-16K18383
[Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory2016
- Author(s)
  Kitamura A, Saito S, Maki A, Ayaki T, Oishi N, Kalaria RN, Hattori Y, Yamamoto Y, Urushitani M, Horsburgh K, Fukuyama H, Takahashi R, Ihara M
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: - Issue: 9 Pages: 1592-1602
- DOI
  10.1177/0271678x15606717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-15K09920
[Journal Article] Velocity of intraneural blood flow is increased in inflammatory neuropathies: sonographic observation.2016
- Author(s)
  Carandang A, Takamatsu N, Nodera H, Mori A, Mimura N, Okada N, Kinoshita H, Kuzuya A, Urushitani M, Takahashi R, Izumi Y, Kaji R.
- Journal Title
  
  J Neurol Neurosurg Psychiatr
  
  Volume: - Issue: 5 Pages: 455-457
- DOI
  10.1136/jnnp-2016-314547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290023
[Journal Article] Localization of a mutant SOD1 protein in E40K-heterozygous dogs: implications for non-cell-autonomous pathogenesis of degenerative myelopathy.2016
- Author(s)
  Kobatake Y, Sakai H, Tsukui T, Yamato O, Kohyama M, Sasaki J, Kato S, Urushitani M, Maeda S, Kamishina H.
- Journal Title
  
  J Neurol Sci
  
  Volume: 372 Pages: 369-378
- DOI
  10.1016/j.jns.2016.10.034
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292181, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-17K07095, KAKENHI-PROJECT-17H03927
[Journal Article] Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy.2016
- Author(s)
  Kawamoto Y, Ayaki T, Urushitani M, Ito H, Takahashi R.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 628 Pages: 207-212
- DOI
  10.1016/j.neulet.2016.06.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-16K18383
[Journal Article] CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.2016
- Author(s)
  Uchida T, Tamaki Y, Ayaki T, Shodai A, Kaji S, Morimura T, Banno Y, Nishitsuji K, Sakashita N, Maki T, Yamashita H, Ito H, Takahashi R, Urushitani M.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 19118-19136
- DOI
  10.1038/srep19118
- NAID
  120005689210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26450403, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-26670190, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-26290023, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-16K08712
[Journal Article] 遺伝子改変によるALSモデルマウス2015
- Author(s)
  山下博史, 漆谷　真
- Journal Title
  
  医学のあゆみ
  
  Volume: 252 Pages: 309-309
- Data Source
  KAKENHI-PROJECT-26290023
[Journal Article] ALSとhnRNPA2B12015
- Author(s)
  玉木良高、漆谷　真
- Journal Title
  
  神経内科
  
  Volume: 82 Pages: 394-397
- Data Source
  KAKENHI-PROJECT-26290023
[Journal Article] A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS2015
- Author(s)
  Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 0n line Issue: 12 Pages: 1-13
- DOI
  10.1093/hmg/ddv093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460386, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-25461302
[Journal Article] Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory.2015
- Author(s)
  Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: 0 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111002
[Journal Article] Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.2015
- Author(s)
  Nakamae S, Kobatake Y, Suzuki R, Tsukui T, Kato S, Yamato O, Sakai H, Urushitani M, Maeda S, Kamishina H.
- Journal Title
  
  Neuroscience
  
  Volume: 303 Pages: 229-240
- DOI
  10.1016/j.neuroscience.2015.06.066
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26660242, KAKENHI-PROJECT-25292181, KAKENHI-PROJECT-26290023
[Journal Article] Proteasome dysfunction induces muscle growth defects and protein aggregation2014
- Author(s)
  Kitajima Y, Tashiro Y, Suzuki N, Warita H, Kato M, Tateyama M, Ando R, Izumi R, Yamazaki M, Abe M, Sakimura K, Ito H, Urushitani M, Nagatomi R, Takahashi R, and Aoki M
- Journal Title
  
  J Cell Sci
  
  Volume: 127 Pages: 5204-5217
- DOI
  10.1242/jcs.150961
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-26350979, KAKENHI-PROJECT-26670436
[Journal Article] Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 12014
- Author(s)
  Oono M, Okado-Matsumoto A, Shodai A,Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M
- Journal Title
  
  J Neurochem
  
  Volume: 128 Pages: 403-418
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine2014
- Author(s)
  Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K
- Journal Title
  
  Exp Biol Med
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Transglutaminase 2 accelerates neuroinflammation in amyotrophic lateral sclerosis through interaction with misfolded superoxide dismutase 1.2014
- Author(s)
  Oono M, Okado-Matsumoto A, Shodai A, Ido A, Ohta Y, Abe K, Ayaki T, Ito H, Takahashi R, Taniguchi N, Urushitani M.
- Journal Title
  
  J Neurochem
  
  Volume: 128（3） Issue: 3 Pages: 403-418
- DOI
  10.1111/jnc.12441
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-24300132
[Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant2014
- Author(s)
  Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 2 Issue: 1 Pages: 172-185
- DOI
  10.1186/s40478-014-0172-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591259, KAKENHI-PROJECT-25860711, KAKENHI-PROJECT-26282218, KAKENHI-PROJECT-26290023, KAKENHI-PROJECT-26560465, KAKENHI-PLANNED-23111002
[Journal Article] Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine.2014
- Author(s)
  Morimura T, Numata Y, Nakamura S, Hirano E, Gotoh L, Goto YI, Urushitani M, Inoue K.
- Journal Title
  
  Exp Biol Med
  
  Volume: 239 Issue: 4 Pages: 489-501
- DOI
  10.1177/1535370213520108
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-25670485
[Journal Article] Amyotrophic Lateral Sclerosis: Symptoms, Treatment and Prognosis.2013
- Author(s)
  Urushitani M and Morimura T
- Journal Title
  
  Nova Science Publishers, Inc.
  
  Volume: 0 Pages: 85-108
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111002
[Journal Article] ミスフォールド蛋白質による神経細胞死と治療戦略2013
- Author(s)
  守村敏史, 高橋良輔, 漆谷真
- Journal Title
  
  遺伝子医学MOOK 別冊「細胞死研究の今-疾患との関わり,創薬に向けてのアプローチ」
  
  Pages: 44-51
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43)2013
- Author(s)
  Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M
- Journal Title
  
  J Biol Chem
  
  Volume: 288(21) Issue: 21 Pages: 14886-14905
- DOI
  10.1074/jbc.m113.451849
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23370080, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PROJECT-25840025
[Journal Article] ミスフォールド蛋白質による神経細胞死と治療戦略.2013
- Author(s)
  守村敏史，高橋良輔，漆谷　真
- Journal Title
  
  遺伝子医学MOOK別冊
  
  Volume: - Pages: 8-8
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43)2013
- Author(s)
  Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M
- Journal Title
  
  J Biol Chem
  
  Volume: 288, 21 Pages: 14886-14905
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Motor Neuron-specific Disruption of Proteasomes, but not Autophagy, Replicates Amyotrophic Lateral Sclerosis2012
- Author(s)
  Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 42984-4299
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 変異SOD1タンパク質によるALSの病態機序2012
- Author(s)
  漆谷真
- Journal Title
  
  脳21「筋萎縮性側索硬化症(ALS)の基礎研究」
  
  Volume: 15 Pages: 9-15
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-432012
- Author(s)
  Shodai A, Ido A, Fujiwara N, Ayaki T, Morimura T, Oono M, Uchida T, Takahashi R, Ito H, Urushitani M
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 変異SOD1タンパク質によるALSの病態機序.2012
- Author(s)
  漆谷　真
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 9-15
- Data Source
  KAKENHI-PLANNED-23111002
[Journal Article] Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-432012
- Author(s)
  Shodai A
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 12 Pages: e52776-e52776
- DOI
  10.1371/journal.pone.0052776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300131, KAKENHI-PROJECT-23580417, KAKENHI-PROJECT-23591259, KAKENHI-PROJECT-24300132, KAKENHI-PLANNED-23111002
[Journal Article] 変異SOD1 タンパク質によるALS の病態機序2012
- Author(s)
  漆谷真
- Journal Title
  
  脳21「筋萎縮性側索硬化症(ALS)の基礎研究」
  
  Volume: 15 Pages: 9-15
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 変異SOD1タンパク質によるALSの病態機序2012
- Author(s)
  漆谷　真
- Journal Title
  
  脳21
  
  Volume: 15 Pages: 9-15
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 神経変性疾患に対する免疫療法の現状2011
- Author(s)
  大野美樹、漆谷真
- Journal Title
  
  細胞工学「脳内免疫システム」
  
  Volume: 10月号(30) Pages: 1054-1059
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 筋萎縮性側索硬化症の免疫療法2011
- Author(s)
  漆谷真
- Journal Title
  
  炎症と免疫「神経免疫の新展開」
  
  Volume: 11月号(19) Pages: 557-563
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model.2011
- Author(s)
  Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R.
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- NAID
  120003163709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] In vivo detection of amyloid β deposition using (19)F magnetic resonance imaging with a (19)F-containing curcumin derivative in a mouse model of Alzheimer's disease.2011
- Author(s)
  Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I.
- Journal Title
  
  Neuroscience.
  
  Volume: 184 Pages: 120-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 筋萎縮性側索硬化症の免疫療法2011
- Author(s)
  漆谷真
- Journal Title
  
  炎症と免疫
  
  Volume: 119 Pages: 557-563
- Data Source
  KAKENHI-PLANNED-23111002
[Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions.2011
- Author(s)
  Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto A, Takahashi R, Ito H.
- Journal Title
  
  Neurology
  
  Volume: 77 Pages: 1995-1997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 筋萎縮性側索硬化症の免疫療法2011
- Author(s)
  漆谷真
- Journal Title
  
  炎症と免疫
  
  Volume: 119 Pages: 557-563
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Protein misdirection inside and outside motor neurons in ALS: a possible clue for therapeutic strategies.2011
- Author(s)
  Ido A, Fukuyama H, Urushitani M.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 12 Pages: 6980-7003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Protein misdirection inside and outside motor neurons in ALS : a possible clue for therapeutic strategies2011
- Author(s)
  Ido A, Fukuyama H, Urushitani M
- Journal Title
  
  Int J Mol Sci
  
  Volume: 12 Pages: 6980-7003
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model2011
- Author(s)
  Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- NAID
  120003163709
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions2011
- Author(s)
  Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto A, Takahashi R, Ito H
- Journal Title
  
  Neurology
  
  Volume: 77 Pages: 1995-1997
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 筋萎縮性側索硬化症の免疫療法2011
- Author(s)
  漆谷真
- Journal Title
  
  炎症と免疫「神経免疫の新展開」 11月号
  
  Volume: 19 Pages: 557-563
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 筋萎縮性側索硬化症の免疫療法2011
- Author(s)
  漆谷真
- Journal Title
  
  炎症と免疫
  
  Volume: 119 Pages: 557-563
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 神経変性疾患に対する免疫療法の現状2011
- Author(s)
  大野美樹、漆谷真
- Journal Title
  
  細胞工学
  
  Volume: 30 Pages: 1054-1059
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 神経変性疾患に対する免疫療法の現状2011
- Author(s)
  大野美樹, 漆谷真
- Journal Title
  
  細胞工学「脳内免疫システム」 10月号
  
  Volume: 30 Pages: 1054-1059
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 神経変性疾患に対する免疫療法の現状2011
- Author(s)
  大野美樹、漆谷真
- Journal Title
  
  細胞工学
  
  Volume: 30 Pages: 1054-1059
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] 神経変性疾患に対する免疫療法の現状2011
- Author(s)
  大野美樹、漆谷真
- Journal Title
  
  細胞工学
  
  Volume: 30 Pages: 1054-1059
- Data Source
  KAKENHI-PLANNED-23111002
[Journal Article] In vivo detection of amyloid β deposition using (19)F magnetic resonance imaging with a (19)F-containing curcumin derivative in a mouse model of Alzheimer's disease2011
- Author(s)
  Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I
- Journal Title
  
  Neuroscience
  
  Volume: 16
- Data Source
  KAKENHI-PROJECT-23300131
[Journal Article] TDP-43の異所性局在機構2010
- Author(s)
  漆谷真
- Journal Title
  
  最新医学「神経変性疾患におけるTDP-43」
  
  Volume: 65 Pages: 1588-1596
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Extracellular mutant SOD1 induces microglial-mediated motoneuron injury2010
- Author(s)
  Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH.
- Journal Title
  
  Glia 58
  
  Pages: 231-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] 免疫療法によるALSの分子標的治療2010
- Author(s)
  漆谷真
- Journal Title
  
  医学のあゆみ「ALS Update」
  
  Volume: 235 Pages: 255-260
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease2010
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A , Tooyama I
- Journal Title
  
  Biomaterial
  
  Volume: 31 Pages: 4179-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.2010
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A, Tooyama I.
- Journal Title
  
  Biomaterials.
  
  Volume: 31 Pages: 4179-4185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 家族性ALSマウスモデルの免疫療法2010
- Author(s)
  漆谷真
- Journal Title
  
  実験医学増刊号「脳神経系の情報伝達と疾患」
  
  Volume: 28 Pages: 799-807
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 家族性ALSマウスモデルの免疫療法2010
- Author(s)
  漆谷真
- Journal Title
  
  実験医学増刊号3月号
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Synergistic effect between proteasome and autophagosome in the clearance of poly-ubiquitinated TDP-43.2010
- Author(s)
  Urushitani M, Sato T, Bamba H, Hisa Y, Tooyama I.
- Journal Title
  
  J Neurosci Res 88
  
  Pages: 784-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Neuronal overexpression of chromogranin A accelerates disease onset in a mouse model of ALS2010
- Author(s)
  Ezzi SA, Lariviere R, Urushitani M, Julien JP
- Journal Title
  
  J Neurochem
  
  Volume: 115 Pages: 1102-1111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 家族性ALSマウスモデルの免疫療法2010
- Author(s)
  漆谷真
- Journal Title
  
  実験医学増刊号 28
  
  Pages: 799-807
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Induction of protective immunity by vaccination with wild-type apo SOD1 in the mutant SOD1 transgenic mice2010
- Author(s)
  Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R, Tooyama I, Taniguchi N, Julien JP, Urushitani M.
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 69 Pages: 1044-1056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Extracellular mutant SOD1 induces microglial-mediated motoneuron injury2010
- Author(s)
  Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH
- Journal Title
  
  Glia
  
  Volume: 58 Pages: 231-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] 免疫療法によるALSの分子標的治療2010
- Author(s)
  漆谷真
- Journal Title
  
  医学のあゆみ
  
  Volume: 235 Pages: 255-260
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.2010
- Author(s)
  Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH.
- Journal Title
  
  Glia
  
  Volume: 58 Pages: 231-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Synergistic effect between proteasome and autophagosome in the clearance of poly-ubiquitinated TDP-432010
- Author(s)
  Urushitani M, Sato T, Bamba H , Hisa Y, Tooyama I
- Journal Title
  
  J Neurosci Res
  
  Volume: 88 Pages: 784-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Induction of protective immunity by vaccination with wild-type apo SOD1 in the mutant SOD1 transgenic mice.2010
- Author(s)
  Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R, Tooyama I, Taniguchi N, Julien JP, Urushitani M.
- Journal Title
  
  J Neuropathol Exp Neurol.
  
  Volume: 69 Pages: 1044-1056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Synergistic effect between proteasome and autophagosome in the clearance of poly-ubiquitinated TDP-432010
- Author(s)
  漆谷真
- Journal Title
  
  J Neurosci Res 88
  
  Pages: 784-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Neuronal overexpression of chromogranin A accelerates disease onset in a mouse model of ALS.2010
- Author(s)
  Ezzi SA, Lariviere R, Urushitani M, Julien JP.
- Journal Title
  
  J Neurochem
  
  Volume: 115 Pages: 1102-1111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Synergistic effect between proteasome and autophagosome in the clearance of poly-ubiquitinated TDP-43.2010
- Author(s)
  Urushitani M, Sato T, Bamba H, Hisa Y, Tooyama I.
- Journal Title
  
  J Neurosci Res
  
  Volume: 88 Pages: 784-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659171
[Journal Article] Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc Natl2009
- Author(s)
  Gros-Louis F, Andersen PM, Dupre N, Urushitani M, Dion P, Souchon F, D'Amour M, Camu W, Meininger V, Bouchard JP, Rouleau GA, Julien JP.
- Journal Title
  
  Acad Sci U S A 106
  
  Pages: 21777-21782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] 筋萎縮性側索硬化症に対するワクチン・抗体療法の展望2009
- Author(s)
  漆谷真
- Journal Title
  
  難病とケア 15
  
  Pages: 35-39
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Axonal ligation induces transient nuclear exclusion of TDP-43 in brainstem motor neurons. Neuroscience 20092009
- Author(s)
  Sato T, Takeuchi S, Saito A, Ding W, Matsuura H, Bamba H, Hisa Y, Tooyama I, Urushitani M.
- Journal Title
  
  Neuroscience 164
  
  Pages: 1565-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] ALSモデルマウスの免疫療法と今後の展望2008
- Author(s)
  漆谷真
- Journal Title
  
  Brain and Nerve 60
  
  Pages: 643-651
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] 筋萎縮性側索硬化症。特集神経変性疾患の診断と治療2008
- Author(s)
  漆谷真
- Journal Title
  
  モダンフィジシャン 28
  
  Pages: 1737-1744
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] The endoplasmic reticulum-Golgi pathway is a major target for translocation and aggregation of mutant superoxide dismutase linked to ALS.2008
- Author(s)
  Urushitani M, Abou Ezzi S, Matsuo A, Tooyama I, Julien JP.
- Journal Title
  
  FASEB J 22
  
  Pages: 2476-2487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] The endoplasmic reticulum-Golgi pathway is a major target for translocation and aggregation of mutant superoxide dismutase linked to ALS2008
- Author(s)
  Urushitani M
- Journal Title
  
  FASEB J 22
  
  Pages: 2476-2487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS2008
- Author(s)
  Urushitani M
- Journal Title
  
  FASEB J「掲載確定」 (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Wild-type SOD1 acquires properties of ALS-linked SOD1 mutants through oxidation.2007
- Author(s)
  Abou Ezzi S, Urushitani M, Julien JP.
- Journal Title
  
  J Neurochem 102
  
  Pages: 170-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Therapeutic effects of immunization with mutant superoxide dismutase in mice models of ALS2007
- Author(s)
  Urushitani M, Abou Ezzi S, Julien JP.
- Journal Title
  
  Proc Natl Acad Sci U S A 104
  
  Pages: 2495-2500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] Therapeutic effects of immunization with mutant superoxide dismutase in mice models of ALS2007
- Author(s)
  Urushitani M
- Journal Title
  
  Proc Nat lAcad Sci USA 104
  
  Pages: 2495-2500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390240
[Journal Article] ALSモデルマウスの免疫療法と今後の展望
- Author(s)
  漆谷真
- Journal Title
  
  Brain and Nerve「掲載確定」
- Data Source
  KAKENHI-PROJECT-19390240
[Patent] 筋萎縮性側索硬化症の原因となる変異型SOD1タンパク質に結合性を有する抗体及び抗体断片2021
- Inventor(s)
  漆谷　真、守村敏史、南山素三雄
- Industrial Property Rights Holder
  漆谷　真、守村敏史、南山素三雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-143179
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03573
[Patent] ボルナウイルスベクターを利用した医薬組成物2021
- Inventor(s)
  朝長敬造、漆谷　真、南山素三雄
- Industrial Property Rights Holder
  朝長敬造、漆谷　真、南山素三雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-143184
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H03573
[Patent] 異常TDP-43を分解除去する抗体断片2019
- Inventor(s)
  漆谷真、玉木良高
- Industrial Property Rights Holder
  漆谷真、玉木良高
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03573
[Patent] 異常TDP-43を分解除去する抗体断片2017
- Inventor(s)
  漆谷真、玉木良高
- Industrial Property Rights Holder
  漆谷真、玉木良高
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-049752
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-26290023
[Patent] TDP-43 の凝集体が蓄積する疾患を治療及び/又は予防するための化合物のスクリーニング方法2013
- Inventor(s)
  漆谷真, 藤原範子, 北原亮, 伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学, 兵庫医科大学, 立命館大学
- Industrial Property Number
  2013-046451
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-23300131
[Patent] TDP-43の凝集体が蓄積する疾患を治療及び／又は予防するための化合物のスクリーニング方法2013
- Inventor(s)
  漆谷真、藤原範子、北原　亮、伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学、兵庫医科大学、立命館大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-046451
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-23300131
[Patent] TDP-43の凝集体が蓄積する疾患を治療2013
- Inventor(s)
  漆谷真、藤原範子、北原　亮、伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学、兵庫医科大学、立命館大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PLANNED-23111002
[Patent] TDP-43の凝集体が蓄積する疾患を治療及び/又は予防するための化合物のスクリーニング方法2013
- Inventor(s)
  漆谷真、藤原範子、北原亮、伊東秀文
- Industrial Property Rights Holder
  漆谷真、藤原範子、北原亮、伊東秀文
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-08
- Overseas
- Data Source
  KAKENHI-PROJECT-23591259
[Patent] TTDP-43の凝集体が蓄積する疾患を治療及び／又は予防するための化合物のスクリーニング方法2013
- Inventor(s)
  漆谷真、藤原範子、北原亮、伊東秀文
- Industrial Property Rights Holder
  漆谷真、藤原範子、北原亮、伊東秀文
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-046451
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-23591259
[Patent] TDP-43の凝集体が蓄積する疾患の発症リスクを予測する方法、診断薬及び治療2012
- Inventor(s)
  漆谷真、藤原範子、伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学、兵庫医科大学、京都大学
- Industrial Property Number
  2012-028737
- Filing Date
  2012-02-13
- Data Source
  KAKENHI-PROJECT-23300131
[Patent] TDP-43の凝集体が蓄積する疾患の発症リスクを予測する方法、診断薬及び治療2012
- Inventor(s)
  漆谷真、藤原範子、伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学、兵庫医科大学、京都大学
- Industrial Property Number
  2012-028737
- Filing Date
  2012-02-13
- Data Source
  KAKENHI-PROJECT-22659171
[Patent] TDP-43の凝集体が蓄積する疾患の発症リスクを予測する方法、診断薬及び治療薬2012
- Inventor(s)
  漆谷真、藤原範子、伊東秀文
- Industrial Property Rights Holder
  漆谷真、藤原範子、伊東秀文
- Industrial Property Rights Type
  特許
- Filing Date
  2012-02-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23591259
[Patent] TDP-43の凝集体が蓄積する疾患の発症リスクを予測する方法、診断薬及び治療薬2012
- Inventor(s)
  漆谷真、藤原範子、伊東秀文
- Industrial Property Rights Holder
  滋賀医科大学、兵庫医科大学、京都大学
- Industrial Property Number
  2012-028737
- Filing Date
  2012-02-13
- Data Source
  KAKENHI-PROJECT-22659171
[Patent] IMAGING DIAGNOSTIC AGENT AND EXTRACORPOREAL DIAGNOSTIC AGENT FOR INCURABLE NEUROLOGICAL DISEASES2010
- Inventor(s)
  遠山育夫、漆谷真、田口弘康、森川茂弘、柳沢大二郎、雨坪知音、白井伸明、平尾浩一、加藤雅也、木村博彦、岡田隆史
- Industrial Property Rights Holder
  滋賀医科大学、滋賀県、石原産業、JST
- Filing Date
  2010-02-26
- Overseas
- Data Source
  KAKENHI-PROJECT-22659171
[Patent] ケト・エノール互変異性を利用した診断薬2009
- Inventor(s)
  遠山育夫, 漆谷真, 田口弘康, 白井伸明, 平尾浩一, 加藤雅也, 柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Number
  2009-045531
- Filing Date
  2009-02-27
- Data Source
  KAKENHI-PROJECT-19390240
[Patent] Antibodies and their use in the treatment, prevention and diagnosis of a disease associated with SOD1 abnormalities2008
- Inventor(s)
  Jean-Pierre Julien, Makoto Urushitani
- Industrial Property Rights Holder
  Universite Laval
- Filing Date
  2008-08-03
- Data Source
  KAKENHI-PROJECT-19390240
[Patent] Antibodies and their use in the treatment, prevention and diagnosis of a disease associated with SOD1 abnormalities2007
- Inventor(s)
  漆谷真Julien JP
- Industrial Property Rights Holder
  ラバル大学
- Filing Date
  2007-08-03
- Overseas
- Data Source
  KAKENHI-PROJECT-19390240
[Patent] ケト・エノール互変異性を利用した診断薬
- Inventor(s)
  遠山育夫、漆谷真、田口弘康、白井伸明、平尾浩一、加藤雅也、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Number
  2009-045531
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Regenerative therapy for chronic ischemic stroke using BM-iMG cells in mice.2025
- Author(s)
  Ngoc Bach Nguyen, Tomoya Terashima, Tomoaki Kitamura, Shuhei Kobashi, Makoto Urushitani
- Organizer
  第24回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-24K10640
[Presentation] 所性局在か凝集体形成か？ALSに関連したミスフォールドタンパク質の構造による役割の違い. ホットトピックス“”New Insights Into ALS: Genes, Proteins, and Pathways”2024
- Author(s)
  漆谷　真
- Organizer
  第６５回　日本神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] 筋萎縮性側索硬化症に起因する情動調節障害が日常生活上のトラブルに与える影響の検証2024
- Author(s)
  金丸恭子、片寄亮、山口未久、宮松直美、漆谷真、荻田美穂子
- Organizer
  第12回日本難病医療ネットワーク学会
- Data Source
  KAKENHI-PROJECT-23K10020
[Presentation] 日本のALS創薬の現状．シンポジウム「日本のALS治験、治療開発のさらなる推進のために」2024
- Author(s)
  漆谷　真
- Organizer
  第42回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] The role of bone marrow-derived inducible microglia-like cells in regulating proinflammatory/anti-inflammatory microglia balance in chronic ischemic stroke.2024
- Author(s)
  Ngoc Bach Nguyen, Tomoya Terashima, Makoto Urushitani
- Organizer
  30th JSGCT第30回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-24K10640
[Presentation] Gene therapy for amyotrophic lateral sclerosis by microRNA with homing peptides to microglia in mice.2024
- Author(s)
  寺島智也，米良和起， Ngoc Bach Nguyen，金子隼也，中村竜太郎，田村亮太，塚本剛士，矢端博行，小橋修平，玉木良高，小川暢弘，北村彰浩，山川勇，漆谷真
- Organizer
  第65回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-24K10640
[Presentation] Influence of Chronic Conditions on Primary Care Utilization at the Onset of Stroke: Shiga Stroke and Heart Attack Registry2024
- Author(s)
  M Kiyohara, N Miyamatsu, A Harada, N Takashima, N Ogawa, S Shitara, M Urushitani, K Yoshida, Ka Miura, K Nozaki
- Organizer
  17th European Public Health Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02704
[Presentation] ALSに対する抗体治療の開発現状.2024
- Author(s)
  漆谷　真
- Organizer
  第36回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] 筋萎縮性側索硬化症に起因する情報調節障害が日常生活上のトラブルに与える影響の検証2024
- Author(s)
  金丸恭子、片寄亮、山口未久、宮松直美、漆谷真、荻田美穂子
- Organizer
  第12回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] 筋萎縮性側索硬化症における病態修飾療法の現在と未来. シンポジウム「病態修飾療法の現在と未来」2024
- Author(s)
  漆谷　真
- Organizer
  第42回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] ALS在宅療養者における非侵襲的人工換気療法に対するイメージの実態2023
- Author(s)
  山口未久, 金丸恭子, 片寄亮, 宮松直美, 漆谷真, 荻田美穂子
- Organizer
  第11回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] ALSの早期介入：栄養・代謝の観点から. シンポジウム「ALSの早期診断・早期介入をいかにやるか」2023
- Author(s)
  中村竜太郎、漆谷　真
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] ALS 診療ガイドドライン2023 の概要．シンポジウム「ALS 診療ガイドライン2023 とこれからの展望」2023
- Author(s)
  漆谷　真
- Organizer
  第４１回日本神経治療学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] 筋萎縮性側索硬化症（ALS）の在宅療養者における情動調節障害の保有状況及び治療介入の実態2023
- Author(s)
  金丸恭子、片寄亮、山口未久、宮松直美、漆谷真、荻田美穂子
- Organizer
  第11回日本難病医療ネットワーク学会
- Data Source
  KAKENHI-PROJECT-23K10020
[Presentation] 筋萎縮性側索硬化症（ALS）の在宅療養者における情動調節障害の保有状況及び治療介入の実態2023
- Author(s)
  金丸恭子, 片寄亮, 山口未久, 宮松直美, 漆谷真, 荻田美穂子
- Organizer
  第11回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] ALS在宅療養者の非侵襲的人工換気療法導入の実態2023
- Author(s)
  荻田美穂子, 金丸恭子, 山口未久, 片寄亮, 宮松直美, 漆谷真
- Organizer
  第11回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] 筋萎縮性側索硬化症の予後とイムノフェノタイプの関連2023
- Author(s)
  漆谷　真
- Organizer
  第35回日本神経免疫学会学術集会.シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] ALS地域医療ネットワークにおける現状と課題2023
- Author(s)
  漆谷　真
- Organizer
  第１１回日本難病医療ネットワーク学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] Long term observation of the cytosolic TDP-43 conformations in the phenotypes of FTLD/ALS in mice2022
- Author(s)
  和田英貴、引網亮太、楠井真季子、南山素三雄、浅田めぐみ、小代明美、漆谷　真
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] ALSにおける治療薬開発ー病態解明の双方向性と今後の展開2022
- Author(s)
  漆谷　真
- Organizer
  第40回　日本神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] タウ分子病理とDNA損傷修復機構の関連について2022
- Author(s)
  浅田めぐみ，植村健吾，綾木孝，上村麻衣子，南山素三雄，引網亮太，守村敏史，小代明美，植木孝俊，高橋良輔，木下彩栄，漆谷真
- Organizer
  第41回　日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24211
[Presentation] COVID-19流行中のALS在宅療養者の生活実態2022
- Author(s)
  山口未久, 荻田美穂子, 金丸恭子, 漆谷真
- Organizer
  第10回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] 在宅療養中ALSにおける専門医受診有無別の重症度及び治療状況2022
- Author(s)
  金丸恭子, 荻田美穂子, 山口未久, 片寄亮, 漆谷真
- Organizer
  第10回日本難病医療ネットワーク学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20345
[Presentation] ALS治療の今と未来展望2021
- Author(s)
  漆谷　真
- Organizer
  第62回　日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] A single intrathecal injection of OPC expressing scFv against misfolded SOD1 improved ALS model rats2021
- Author(s)
  南山素三雄、酒井まどか、山口裕子、引網亮太、和田英貴、端真季子、小代明美、牧野晶子、眞木崇州、朝長啓造、高橋良輔、漆谷　真
- Organizer
  第62回　日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] ALSの病原蛋白質に対する抗体治療戦略2020
- Author(s)
  漆谷　真
- Organizer
  第61回日本神経学会学術集会.
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] Therapeutic effects of bone marrow-derived neuroprotective microglia in ALS model mice2020
- Author(s)
  小橋修平、寺島智也、柏木駿也、樫　美和子、中江由希、小嶋秀人、漆谷　真
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] novel cell transplantation therapy for familial ALS using oligodendrocyte precursor cells expressing scFv recognizing misfolded SOD12019
- Author(s)
  Minamiyama S, Sakai M, Yamaguchi Y, Hikiami R, Tamaki Y, Shodai A, Maki T, Tomonaga K, Takahashi R, Urushitani M
- Organizer
  第60回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] Combined bone marrow transplantation therapy of MNCs and growth factor expressing-MSCs for ALS2019
- Author(s)
  Terashima T, Kobashi S, Watanabe Y, Nakanishi M, Honda N, Katagi M, Nakae Y, Ohashi N, Urushitani M, Kojima H
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] ALS治療の近未来展望2019
- Author(s)
  漆谷真
- Organizer
  第46回日本脳科学会基調講演
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] novel cell transplantation therapy for familial ALS using oligodendrocyte precursor cells expressing scFv specific for misfolded SOD12019
- Author(s)
  Minamiyama S, Sakai M, Yamaguchi Y, Hikiami R, Tamaki Y, Shodai A, Makino A, Maki T, Tomonaga K, Takahashi R, Urushitani M
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] Sequestration of RNA helicase DHX30 from mitochondrion is linked to mitochondrial dysfunction in ALS-FUS2019
- Author(s)
  Hikiami R, Minamiyama S, Asada M, Wada H, Shodai A, Morimura S, Ayaki T, Takahashi R, Urushitani M
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] ALS免疫療法の新展開2019
- Author(s)
  漆谷真
- Organizer
  第60回日本神経学会学術大会教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] 筋萎縮性側索硬化症に対する免疫療法2019
- Author(s)
  漆谷真
- Organizer
  第31回日本神経免疫学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody.2019
- Author(s)
  Makoto Urushitani
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society The 62nd Annual Meeting of the Japanese Society for Neurochemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] ALS病原蛋白質の局在に基づく抗体医療戦略2019
- Author(s)
  漆谷真
- Organizer
  第 37 回日本神経治療学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03573
[Presentation] Degradative intrabody for selective elimination of pathogenic TDP-43 aggregates in vitro and in murine embryos’ cerebrum2017
- Author(s)
  Tamaki Y, Shodai A, Hikiami R, Minamiyama S, Morimura T, Ayaki T, Takahashi R, Urushitani M.
- Organizer
  World Congress of Neurology. 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 孤発性筋萎縮性側索硬化症における細胞内抗体を用いた異常TDP-43除去の試み2017
- Author(s)
  漆谷　真.
- Organizer
  第29回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Development of an effective technology for inductive differentiation from bone marrow-derived mononuclear cells to neuroprotective microglia.2017
- Author(s)
  Kobashi S, Terashima T, Nakae Y, Katagi M, Morimura T, Kojima H, Urushitani M
- Organizer
  World Congress of Neurology. 2017,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 骨髄単核球の細胞保護型ミクログリア細胞への分化誘導法の検討～神経変性疾患の細胞治療への応用を目指して2017
- Author(s)
  小橋修平　寺島智也　中江由希　樫美和子　守村敏史　小島秀人漆谷真
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] Cilostazol reduced gliovascular damage and working memory impairment via endotelial protection in a mouse model of vascular dementia.2017
- Author(s)
  itamura A, Sanz Y, Duncombe J, Koudelka J, Binnie M, Lennen R, Webster S, Jansen M, Marshall I, Ogawa N, Urushitani M, Kalaria R, Ihara M, Horsburgh K.
- Organizer
  World Congress of Neurology. 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Pathological analysis of a novel conformational specific anti-SOD1 antibody using human and mice tissues in amyotrophic lateral sclerosis2017
- Author(s)
  Yamaguchi Y, Ayaki T, Urushitani M, Takahashi R.
- Organizer
  World Congress of Neurology. 2017,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 分解型細胞内抗体を用いたALSの分子標的治療2017
- Author(s)
  漆谷　真.
- Organizer
  第35回日本神経治療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 病原蛋白質特異的エピトープに対するALSの分子標的治療開発戦略.2017
- Author(s)
  漆谷　真.
- Organizer
  日本薬学会, 次世代を担う創薬・医療薬理シンポジウム2017
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Myositis and muscular inclusions in Nakajo-Nishimura syndrome.2017
- Author(s)
  Ayaki T, Murata K, Kanazawa N, Uruha A, Nishino I, Omura K, Sugie K, Mori M, Ueno S, Furukawa F, Ito H, Urushitani M, Takahashi R
- Organizer
  World Congress of Neurology. 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 上位運動ニューロン徴候を主徴とし、急速に進行したTDP-43変異筋萎縮性側索硬化症の剖検例2016
- Author(s)
  北川尚之、内野彰子、山下博史、漆谷　真、櫻井道雄、村山繁雄
- Organizer
  第57回日本神経病理学会総会学術研究会.
- Place of Presentation
  弘前
- Year and Date
  2016-06-01
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 自己免疫性てんかんにおける末梢血リンパ球の表面抗原解析2016
- Author(s)
  端祐一郎、坂本光弘、十川純平、岡田洋一郎、藤井ちひろ、越智博文、中川正法、水野俊樹、下竹昭寛、松本理器、漆谷　真、池田昭夫、高橋良輔
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] 再発性多発軟骨炎に伴う脳炎2症例の検討2016
- Author(s)
  岡田信久、和田隆史、樽野陽亮、眞木崇州、吉藤元、丹治正大、三橋賢大、山門穂高、上田紗希帆、前川嵩太、引網亮太、木下久徳、綾木孝、山下博史、澤本伸克、漆谷真、池田昭夫、高橋良輔.
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] The development of therapeutic intrabody against misfolded TDP-43 for ALS2016
- Author(s)
  Tamaki Y, Shodai A, Hikiami R, Minamiyama S, Ayaki T, Takahashi R, Urushitani M
- Organizer
  Annual Meeting of Society for Neuroscience. 2016
- Place of Presentation
  San Diego　（U.S.A)
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Measurement of TDP-43 in peripheral blood cells of ALS.2016
- Author(s)
  菱澤美貴、山下博史、漆谷真、高橋良輔
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Activation of caspase-9 in the neuronal and glial elements in dementia with Lewy bodies2016
- Author(s)
  河本恭裕、綾木孝、漆谷　真、伊東秀文、高橋良輔
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] The mechanism of Motor Neuron Degeneration in Ubiquitin Proteasome System Dysfunction2016
- Author(s)
  星野友則、山下博史、田代善祟、三澤日出己、漆谷　真、高橋良輔
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Impaired VHL/CUL2-mediated clearance of misfolded TDP-43 underlies glial cytoplasmic inclusions (GCIs) in ALS2016
- Author(s)
  漆谷　真
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸市
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] The development of therapeutic intrabody against misfolded/unfolded TDP-43 for ALS2016
- Author(s)
  玉木良高、小代明美、綾木孝、高橋良輔、漆谷　真.
- Organizer
  第57回日本神経学会　学術集会
- Place of Presentation
  神戸
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] VHL/CUL2によるミスフォールド型TDP-43の分解障害とオリゴデンドロサイト封入体形成2016
- Author(s)
  漆谷　真
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Clinicopathologic study of autopsied familial ALS cases with optineurin mutation2015
- Author(s)
  綾木　孝, 伊東秀文、小牟禮修、辰己新水、鎌田正紀、漆谷　真、川上秀史、髙橋良輔
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] TDP-43の病原構造の同定と抗体を用いた分子標的治療.2015
- Author(s)
  漆谷　真
- Organizer
  第56回　日本神経学会学術集会. シンポジウム；運動ニューロン疾患の分子病態・治療法開発の最先端.
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] TDP-43の病原構造の同定と抗体を用いた分子標的治療2015
- Author(s)
  漆谷　真
- Organizer
  第56回　日本神経学会学術集会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像：若年発症例を含む4症例の検討2015
- Author(s)
  引網亮太,, 端祐一郎, 山門穂高,　辰己　新水,　山下博史,　澤本伸克,　辻輝之,　川本未知,　幸原伸夫,　井上治久,　漆谷真,　高橋良輔
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像：若年発症例を含む4症例の検討.2015
- Author(s)
  引網亮太,, 端祐一郎, 山門穂高,　辰己　新水,　山下博史,　澤本伸克,　辻輝之,　川本未知,　幸原伸夫,　井上治久,　漆谷真,　高橋良輔.
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] Immunohistochemical localization of HAX-1 and PALR in Lewy bodies in PD and DLB.2015
- Author(s)
  河本恭裕、辰己新水、漆谷　真、伊東秀文、髙橋良輔.
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] VHL とCUL2; TDP-43 の凝集を促進するVHL と分解を促進するCUL2. TDP-43 proteinopathy におけるVHL の2 面性.2015
- Author(s)
  内田司, 玉木良高, 小代明美, 綾木孝, 守村敏史, 辰巳新水, 伊東秀文, 坂下直実, 高橋良輔, 漆谷真.
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] The Mechanism of Motor Neuron Degeneration in Ubiquitin Proteasome System Dysfunction2015
- Author(s)
  星野　友則、Yamashita H, Tashiro Y, Misawa H, Makoto U, Takahashi R
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] VHLとCUL2;TDP-43の凝集えを促進するVHLと分解を促進するCUL22015
- Author(s)
  内田　司、小代　明美、玉木　良高、辰己　新水、守村　敏史、綾木　孝、伊藤　秀文、坂下　直美、高橋　良輔、漆谷　真
- Organizer
  第56回日本神経学会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26450403
[Presentation] 多発性硬化症患者におけるTLR/CD40刺激によるB細胞サイトカインの解析2015
- Author(s)
  岡田洋一郎、藤井ちひろ、端祐一郎、越智博文、中川正法、水野敏樹、松本禎之、漆谷　真、髙橋良輔、近藤誉之.
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] VHL とCUL2; TDP-43 の凝集を促進するVHL と分解を促進するCUL2. TDP-43 proteinopathy におけるVHL の2 面性2015
- Author(s)
  内田司, 玉木良高, 小代明美, 綾木孝, 守村敏史, 辰巳新水, 伊東秀文, 坂下直実, 高橋良輔, 漆谷真
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Clinicopathologic study of autopsied familial ALS cases with optineurin mutation.2015
- Author(s)
  綾木　孝, 伊東秀文、小牟禮修、辰己新水、鎌田正紀、漆谷　真、川上秀史、髙橋良輔.
- Organizer
  第56回日本神経学会　学術集会
- Place of Presentation
  新潟
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] Immunotherapy targeting loop VI in Cu,Zn-superoxide dismutase exacerbates ALS pathogenesis2014
- Author(s)
  Fujiwara Noriko, Urushitani Makoto, Yoshihara Daisaku, Morimura Toshifumi Sakiyama Haruhiko, Eguchi Hironobu, Suzuki Keiichiro
- Organizer
  SFRRI2014
- Place of Presentation
  Kyoto
- Year and Date
  2014-03-24
- Data Source
  KAKENHI-PROJECT-23591259
[Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
- Author(s)
  内田司、小代明美、守村敏史、辰巳新水、高橋良輔、漆谷真
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] Immunotherapy targeting loop VI in Cu,Zn-superoxide dismutase exacerbates ALS pathogenesis2014
- Author(s)
  Fujiwara Noriko, Urushitani Makoto, Yoshihara Daisaku, Morimura Toshifumi Sakiyama Haruhiko, Eguchi Hironobu, Suzuki Keiichiro
- Organizer
  SFRRI 2014
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591259
[Presentation] Clinical, histopathological, and biochemical characterization of the canine model of SOD1-mediated amyotrophic lateral sclerosis2014
- Author(s)
  Kobatake Yui, Oyake Kanae, Tsukui Toshihiro, Sakai Hiroki, Yamato Osamu, Saito Miyoko, Urushitani Makoto, Kato Shinsuke, Sasaki Jun, Shibata Sanae, Maeda Sadatoshi, Kamishina Hiroaki
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] TDP-43のCullin-2型E3リガーゼの同定及び機能解析2014
- Author(s)
  内田司, 小代明美, 大野美樹, 辰巳新水, 守村敏史, 高橋良輔, 漆谷真
- Organizer
  第55回日本神経学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] The role of conformation of RNA recognition motifs of TDP-43 in the protein quality control system in ALS2014
- Author(s)
  Makoto Urushitani
- Organizer
  第３7回日本神経科学大会第6回日本カナダ合同シンポジウム
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] VHL, a modifier of degradation, aggregation and compartmentation of TDP-43 in ALS pathology.2014
- Author(s)
  内田司、小代明美、玉木良高、辰巳新水、守村敏史、高橋良輔、漆谷真
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
- Author(s)
  内田司，小代明美，守村敏史，辰巳新水，高橋良輔，漆谷真
- Organizer
  第３7回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] The role of conformation of RNA recognition motifs of TDP-43 in the protein quality control system in ALS2014
- Author(s)
  Makoto Urushitani
- Organizer
  6th Japan-Canada joint symposium. 37th Annual Meeting of Japan Neuroscience Society
- Place of Presentation
  横浜市
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] The role of conformation of RNA recognition motifs of TDP-43 in the protein quality control system in ALS2014
- Author(s)
  Makoto Urushitani
- Organizer
  6th Japan-Canada joint symposium. 37th Annual Meeting of Japan Neuroscience Society
- Place of Presentation
  横浜
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割2014
- Author(s)
  内田司，小代明美，守村敏史，辰巳新水，高橋良輔，漆谷真
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] イヌの筋萎縮性側索硬化症モデルの臨床像、病理像および変異型SOD1蛋白の生化学的特性2014
- Author(s)
  小畠結，小宅香苗，津久井利広，酒井洋樹，大和修，齋藤弥代子，漆谷真，加藤信介，佐々木淳，柴田早苗，前田貞俊，神志那弘明
- Organizer
  第３7回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26290023
[Presentation] Molecular epitope identifi cation for misfolded/unfolded TDP-43 in ALS2014
- Author(s)
  Makoto Urushitani
- Organizer
  10th Annual Symposium of ALS of the Foundation Andre-Delambre.
- Place of Presentation
  カナダ
- Year and Date
  2014-09-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] ALSのTDP-43のinclusion形成におけるVon Hippel-Lindau proteinの役割（ポスター）2014
- Author(s)
  内田司、小代明美、守村敏史、辰己新水、高橋良輔、漆谷真
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-14
- Data Source
  KAKENHI-ORGANIZER-23111001
[Presentation] 筋萎縮性側索硬化症に対する抗体医療研究の現状2013
- Author(s)
  漆谷　真
- Organizer
  第18回　日本神経感染症学会総会学術集会
- Place of Presentation
  宮崎市
- Invited
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 筋萎縮性側索硬化症に対する抗体医療研究の現状2013
- Author(s)
  漆谷真
- Organizer
  第18回日本神経感染症学会総会学術集会シンポジウム
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] イヌ変性性脊髄症に認められる変異型SOD1蛋白（E40K）に対するモノクローナル抗体の作製と特異性の解析2013
- Author(s)
  小畠結, 漆谷真, 加藤信介, 酒井洋樹, 大和修, 津久井利広, 鈴木理恵子, 前田貞俊, 神志那弘明
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] TDP-43の核外脱出シグナル内に存在する酸性アミノ酸がその構造と機能維持に及ぼす役割について2013
- Author(s)
  漆谷真，小代明美，綾木孝，藤原範子，伊東秀文
- Organizer
  第３６回日本神経科学大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 筋萎縮性側索硬化症の病態に即した抗体医療戦略2013
- Author(s)
  漆谷真
- Organizer
  第22回日本Cell death 学会学術集会シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] TDP-43 の核外脱出シグナル内に存在する酸性アミノ酸がその構造と機能維持に及ぼす役割について2013
- Author(s)
  漆谷真, 小代明美, 綾木孝, 藤原範子, 伊東秀文
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  京都
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 筋萎縮性側索硬化症の病態に即した抗体医療戦略2013
- Author(s)
  漆谷　真
- Organizer
  第22回日本Cell death学会　学術集会
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 家族性ALSモデルの神経炎症におけるトランスグルタミナーゼ２介在性SOD1オリゴマーの関与2013
- Author(s)
  大野美樹，松本紋子，谷口直之，高橋良輔，漆谷真
- Organizer
  第３６回日本神経科学大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] テトラサイクリン誘導性にTDP-43 を発現するヒト神経由来細胞の樹立とその応用2012
- Author(s)
  内田司, 井戸明美, 高橋良輔, 漆谷真
- Organizer
  第53回日本神経学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] イヌの変性性脊髄症におけるミクロクリアの組織学的解析と細胞傷害因子の定量2012
- Author(s)
  山田修平, 酒井洋樹, 千村直輝, 漆谷真, 大和修, 加藤信介, 内田和幸, 小川瑞恵, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] イヌの変性性脊髄症に認められる変異型SOD1蛋白の生化学的解析2012
- Author(s)
  並木まり子, 漆谷真, 大和修, 津久井利広, 鈴木理恵子, 加藤信介, Janice Robertson, Kate Banks, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] イヌの変性性脊髄症における変異型SOD1蛋白凝集体の証明2012
- Author(s)
  中前早百合, 漆谷真, 加藤信介, 酒井洋樹, 大和修, 内田和幸, 小川瑞恵, 津久井利広, 鈴木理恵子, 前田貞俊, 神志那弘明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  岩手大学(盛岡市)
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-24380169
[Presentation] Variant forms of human chromogranin B fail to interact with mutant SOD1.2011
- Author(s)
  Ohta Y, Audet JN, Phaneuf D, Urushitani M, Julien JP.
- Organizer
  Annual Meeting of Neuroscience.
- Place of Presentation
  ワシントンD.C.（米国）
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] 神経変性疾患における抗体療法「筋萎縮性側索硬化症の抗体療法」2011
- Author(s)
  漆谷真
- Organizer
  第52回日本神経学会学術集会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 7th ALS Research Forum, ALS Society of Canada2011
- Author(s)
  Makoto Urushitani
- Organizer
  Molecular targeting strategies against misfolded proteins in ALS
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] Molecular targeting strategies against misfolded proteins in ALS2011
- Author(s)
  Urushitani M
- Organizer
  7th ALS Research Forum, ALS Society of Canada
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 神経変性疾患における抗体療法2011
- Author(s)
  漆谷真
- Organizer
  「筋萎縮性側索硬化症の抗体療法」第52回日本神経学会学術集会シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 神経変性疾患における抗体療法「筋萎縮性側索硬化症の抗体療法」2011
- Author(s)
  漆谷真
- Organizer
  第52回日本神経学会学術集会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] Molecular targeting strategies against misfolded proteins in ALS2011
- Author(s)
  漆谷真
- Organizer
  7th ALS Research Forum, ALS Society of Canada
- Place of Presentation
  トロント(カナダ)(招待講演)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] 神経変性疾患における抗体療法「筋萎縮性側索硬化症の抗体療法」2011
- Author(s)
  漆谷真
- Organizer
  第52回日本神経学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] 筋萎縮性側索硬化症の抗体療法2011
- Author(s)
  漆谷真
- Organizer
  第52回日本神経学会学術集会シンポジウム；神経変性疾患における抗体療法
- Place of Presentation
  名古屋
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] ALSモデルマウスにおけるトランスグルタミナーゼ2の誘導2011
- Author(s)
  大野美樹, 井戸明美, 松本紋子, 谷口直之, 高橋良輔, 漆谷真
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] Molecular targeting strategies against misfolded proteins in ALS2011
- Author(s)
  漆谷真
- Organizer
  7th ALS Research Forum, ALS Society of Canada
- Place of Presentation
  トロント(カナダ)(招待講演)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] ALS モデルマウスにおけるトランスグルタミナーゼ2の誘導2011
- Author(s)
  大野美樹, 井戸明美, 松本紋子, 谷口直之, 高橋良輔, 漆谷真
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300131
[Presentation] Molecular targeting strategies against misfolded proteins in ALS2011
- Author(s)
  漆谷真
- Organizer
  7th ALS Research Forum, ALS Society of Canada
- Place of Presentation
  トロント(カナダ)
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PLANNED-23111002
[Presentation] ALSの免疫療法2010
- Author(s)
  漆谷真
- Organizer
  Neuro2010 (第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会) シンポジウム「若手研究者が展開する筋萎縮性側索硬化症研究の将来展望」（兼シンポジウムオーガナイザー）
- Place of Presentation
  神戸
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] ALSの免疫療法2010
- Author(s)
  漆谷真
- Organizer
  euro 2010(第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会)シンポジウム;若手研究者が展開する筋萎縮性側索硬化症研究の将来展望
- Place of Presentation
  神戸市(招待講演)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] TDP-43の異所性局在とALSの病理現象との関連について2010
- Author(s)
  漆谷真、佐藤尚志
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] 筋萎縮性側索硬化症研究におけるモデル動物のインパクト2010
- Author(s)
  漆谷真
- Organizer
  第107回関西実験動物研究会
- Place of Presentation
  大津市(招待講演)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] 筋萎縮性側索硬化症の免疫療法について2010
- Author(s)
  漆谷真
- Organizer
  第22回日本神経免疫学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-03-22
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 筋萎縮性側索硬化症の免疫療法について2010
- Author(s)
  漆谷真
- Organizer
  神経免疫学会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] ALS治療標的の解明現状について2010
- Author(s)
  漆谷真
- Organizer
  第1回熊本ALSフォーラム
- Place of Presentation
  熊本
- Year and Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] TDP-43の異所性局在とALSの病理現象との関連について2010
- Author(s)
  漆谷真、佐藤尚志
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22659171
[Presentation] 免疫療法によるALSの治療戦略2009
- Author(s)
  漆谷真
- Organizer
  第50回日本神経学会総会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 免疫療法によるALSの治療戦略2009
- Author(s)
  漆谷真
- Organizer
  第50回日本神経学会総会シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Neuronal overexpression of chromogranin A accelerates motor neuron degeneration in a mouse model of ALS.2009
- Author(s)
  Abou Ezzi S, Urushitani M, Lariviere R, Julien JP.
- Organizer
  20th International Symposium on ALS/MND
- Place of Presentation
  Berlin
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 異常タンパク病としての筋萎縮性側索硬化症～治療を志向した研究動向～2009
- Author(s)
  漆谷真
- Organizer
  第10回大阪神経治療研究会
- Place of Presentation
  大阪
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Genetic screening study of CHGA and CHGB variants in a cohort of patients with amyotrophic lateral sclerosis2008
- Author(s)
  Dupre N, Gros-Louis F, Andersen P, Urushitani M, Meininger V, Salachas F, Camu W, Bouchard JP, Rouleau G, Julien JP.
- Organizer
  Annual meeting of American Academy of Neurology
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 筋萎縮性側索硬化症におけるミスフォールドタンパクの多様性機序2008
- Author(s)
  漆谷真
- Organizer
  第17回日本アポトーシス研究会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 筋萎縮性側索硬化症におけるミスフォールドタンパクの多様性機序2008
- Author(s)
  漆谷真
- Organizer
  第17回日本アポトーシス研究会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-08-01
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Axonal strangulation induced peripheral accumulation and nuclear reduction of TDP43 in brainstem motor neurons2008
- Author(s)
  Satoh T, Takeuchi S, Saitoh A, Hisa Y, Tooyama I, Urushitani M.
- Organizer
  Annual Meeting of Neuroscience.
- Place of Presentation
  Washington D.C.
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Oxidized wild type SOD1 acquires toxic properties reminiscent of mutant SOD1 species2007
- Author(s)
  Abou Ezzi S, Urushitani M, Julien JP.
- Organizer
  Annual Meeting of Neuroscience. Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 家族性筋萎縮性側索硬化症に対する免疫療法2007
- Author(s)
  漆谷真
- Organizer
  日本脳科学会総会
- Place of Presentation
  出雲
- Year and Date
  2007-06-08
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] 家族性筋萎縮性側索硬化症モデルマウスに対する免疫療法の試み2007
- Author(s)
  漆谷真
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] The Activation of Microglia by Mutant SOD1 Protein: A Novel Link between Innate Immunity and ALS.2007
- Author(s)
  Zhao W, Beer DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel S.
- Organizer
  59th Annual Meeting, American Academy of Neurology
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-19390240
[Presentation] Conserved acidic amino acid residues in the nuclear export signal of the RNA interacting domain regulates conformation and function of TDP-43
- Author(s)
  Makoto Urushitani, Akemi Shodai, Takashi Ayaki, Noriko Fujiwara, Hidefumi Ito
- Organizer
  Neuro 2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23591259

1. Toshifumi Morimura (20333338)

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Urushitani Makoto 漆谷 真

URUSHITANI Makoto 漆谷 真

漆谷 真 ウルシタニ マコト

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新規ミトコンドリア蛋白質の構造異常によるALS病態の解析と評価モデル系の開発Principal Investigator

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A novel cell transplantation therapy for ALS using scFv-secreting OPCsPrincipal Investigator

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Development of a novel molecular targeting therapy and probe, using antibodies against pathogenic epitopes in TDP-43Principal Investigator

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Identification of pathogenic domain in TDP-43 for ALS toward the antibody medicinePrincipal Investigator

Urushitani Makoto 漆谷真

URUSHITANI Makoto 漆谷真

漆谷真ウルシタニマコト