Komatsu Yoshito 小松嘉人

… Alternative Names

小松嘉人コマツヨシト

KOMATSU YOSHITO 小松嘉人

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Researcher Number	60333598
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道大学, 大学病院, 准教授 2013 – 2016: 北海道大学, 大学病院, 准教授
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 癌幹細胞 / 薬剤耐性 / Lenvatinib / がん幹細胞 / PARP阻害剤 / HCC / 肝細胞癌 / 三次元培養 / ＣＤ４４ / 3次元培養 … More / CD44 / 食道扁平上皮癌 / EGFR阻害剤 / 癌幹細胞ニッチ … More Except Principal Investigator 抗癌剤耐性 / 薬剤耐性 Less

PARP inhibitor resistance in cancer stem cells in hepatocelular carcinomaPrincipal Investigator
- Principal Investigator
  
  小松嘉人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Analysis of cancer stem cell niche by using esophageal orgnotypic 3D culture systemPrincipal Investigator
- Principal Investigator
  
  Yoshito Komatsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.
- Principal Investigator
  
  Kobayashi Takahiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University

All 2024 2023 2022 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer2024
- Author(s)
  Shitara Kohei、Muro Kei、Watanabe Jun、Yamazaki Kentaro、Ohori Hisatsugu、Shiozawa Manabu、Takashima Atsuo、Yokota Mitsuru、Makiyama Akitaka、Akazawa Naoya、Ojima Hitoshi、Yuasa Yasuhiro、Miwa Keisuke、Yasui Hirofumi、Oki Eiji、Sato Takeo、Naitoh Takeshi、Komatsu Yoshito、Tsuchihara Katsuya、Yoshino Takayuki
- Journal Title
  
  Nature Medicine
  
  Volume: 30 Issue: 3 Pages: 730-739
- DOI
  10.1038/s41591-023-02791-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Correlation of UGT1A1 Gene Polymorphisms or Prior Irinotecan Treatment and Treatment Outcomes of Nanoliposomal-Irinotecan plus 5-Fluorouracil/Leucovorin for Pancreatic Ductal Adenocarcinoma: A Multicenter, Retrospective Cohort Study (HGCSG2101)2023
- Author(s)
  Harada Kazuaki、Yamamura Takahiro、Muto Osamu、Nakamura Michio、Sogabe Susumu、Sawada Kentaro、Nakano Shintaro、Yagisawa Masataka、Muranaka Tetsuhito、Dazai Masayoshi、Tateyama Miki、Kobayashi Yoshimitsu、Kato Sosuke、Hatanaka Kazuteru、Kawamoto Yasuyuki、Yuki Satoshi、Sakata Yuh、Sakamoto Naoya、Komatsu Yoshito
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 4 Pages: 1596-1596
- DOI
  10.3390/jcm12041596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Identification of an optimal mutant allele frequency to detect activating KRAS, NRAS, and BRAF mutations in a commercial cell-free DNA next-generation sequencing assay in colorectal and pancreatic adenocarcinomas2023
- Author(s)
  Caughey Bennett A.、Umemoto Kumiko、Green Michelle F.、Ikeda Masafumi、Lowe Melissa E.、Ueno Makoto、Niedzwiecki Donna、Taniguchi Hiroya、Walden Daniel J.、Komatsu Yoshito、Yoshino Takayuki、Strickler John H.、Nakamura Yoshiaki
- Journal Title
  
  Journal of Gastrointestinal Oncology
  
  Volume: 14 Issue: 05 Pages: 2083-2096
- DOI
  10.21037/jgo-23-114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis2023
- Author(s)
  Sakurai Kensuke、Katsurada Takehiko、Nishida Mutsumi、Omotehara Satomi、Fukushima Shinya、Otagiri Shinsuke、Nagashima Kazunori、Onishi Reizo、Takagi Ryo、Komatsu Yoshito、Sakamoto Naoya
- Journal Title
  
  Intestinal Research
  
  Volume: 21 Issue: 1 Pages: 126-136
- DOI
  10.5217/ir.2021.00166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma2023
- Author(s)
  Goyal L, Meric-Bernstam F, Hollebecque A, Valle JW, Morizane C, Karasic TB, Abrams TA, Furuse J, Kelley RK, Cassier PA, Klumpen HJ, Chang HM, Chen LT, Tabernero J, Oh DY, Mahipal A, Moehler M, Mitchell EP, Komatsu Y, Masuda K, Ahn D, Epstein RS, Halim AB, Fu Y, Salimi T, Wacheck V, He Y, Bridgewater JA
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 388 Issue: 3 Pages: 228-239
- DOI
  10.1056/nejmoa2206834
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Anti-epidermal growth factor receptor treatment for patients with Neo RAS wild-type metastatic colorectal cancer: a case report of two cases2023
- Author(s)
  Harada Kazuaki、Yuki Satoshi、Kawamoto Yasuyuki、Nakamura Takeaki、Kaneko Shiho、Ishida Koichi、Sakamoto Naoya、Komatsu Yoshito
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 15
- DOI
  10.1177/17588359231216090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] A randomised phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel for locally advanced pancreatic cancer (JCOG1407)2023
- Author(s)
  Ozaka Masato、Mizuno Nobumasa、et al.
- Journal Title
  
  European Journal of Cancer
  
  Volume: 181 Pages: 135-144
- DOI
  10.1016/j.ejca.2022.12.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08433, KAKENHI-PROJECT-22K08023, KAKENHI-PROJECT-20K16984
[Journal Article] Phase I Study of the Liposomal Formulation of Eribulin (E7389-LF): Results from the Advanced Gastric Cancer Expansion Cohort2023
- Author(s)
  Shitara Kohei、Hirao Motohiro、Iwasa Satoru、Oshima Takashi、Komatsu Yoshito、Kawazoe Akihito、Sato Yasuyoshi、Hamakawa Takuya、Yonemori Kan、Machida Nozomu、Yuki Satoshi、Suzuki Takuya、Okumura Shiori、Takase Takao、Semba Taro、Zimmermann Bob、Teng Angela、Yamaguchi Kensei
- Journal Title
  
  Clinical Cancer Research
  
  Volume: CCR-22-3027 Issue: 8 Pages: 1460-1467
- DOI
  10.1158/1078-0432.ccr-22-3027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome2022
- Author(s)
  Saito Rika、Kawamoto Yasuyuki、Nishida Mutsumi、Iwai Takahito、Kikuchi Yasuka、Yokota Isao、Takagi Ryo、Yamamura Takahiro、Ito Ken、Harada Kazuaki、Yuki Satoshi、Komatsu Yoshito、Sakamoto Naoya
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 11 Pages: 1780-1790
- DOI
  10.1007/s10147-022-02235-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial2022
- Author(s)
  Kurokawa Y.、Honma Y.、Sawaki A.、Naito Y.、Iwagami S.、Komatsu Y.、Takahashi T.、Nishida T.、Doi T.
- Journal Title
  
  Annals of Oncology
  
  Volume: 33 Issue: 9 Pages: 959-967
- DOI
  10.1016/j.annonc.2022.05.518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08023, KAKENHI-PROJECT-22K08883
[Journal Article] Feasibility of edoxaban for asymptomatic cancer-associated thrombosis in Japanese patients with gastrointestinal cancer: ExCAVE study2022
- Author(s)
  Nakamura Michio、Ishiguro Atsushi、Dazai Masayoshi、Kawamoto Yasuyuki、Yuki Satoshi、Sogabe Susumu、Hosokawa Ayumu、Sawada Kentaro、Muto Osamu、Izawa Naoki、Nakashima Koji、Horie Yoshiki、Yagisawa Masataka、Kajiura Shinya、Ando Takayuki、Mitsuhashi Yosuke、Sunakawa Yu、Kikuchi Yasuka、Komatsu Yoshito
- Journal Title
  
  BMC Cancer
  
  Volume: 22 Issue: 1 Pages: 1322-1322
- DOI
  10.1186/s12885-022-10403-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023
[Journal Article] Analysis of the Pancreatic Cancer Microbiome Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration-Derived Samples2022
- Author(s)
  Nakano S, Kawamoto Y, Komatsu Y, Saito R, Ito K, Yamamura T, Harada K, Yuki S, Kawakubo K, Sugiura R, Kato S, Hirata K, Hirata H, Nakajima M, Furukawa R, Takishin Y, Nagai K, Yokota I, Ota KH, Nakaoka S, Kuwatani M, Sakamoto N.
- Journal Title
  
  Pancreas
  
  Volume: 51 Issue: 4 Pages: 351-357
- DOI
  10.1097/mpa.0000000000002028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08023, KAKENHI-PROJECT-21K19813, KAKENHI-PROJECT-22K16034
[Journal Article] Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer.2017
- Author(s)
  Kobayashi T, Ishida J, Shimizu Y, Kawakami H, Suda G, Muranaka T, Komatsu Y, Asaka M, Sakamoto N.
- Journal Title
  
  Tumour Biol
  
  Volume: 39 Issue: 3 Pages: 101042831769454-101042831769454
- DOI
  10.1177/1010428317694547
- NAID
  120006318739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460933
[Journal Article] S-1 plus leucovorin versus S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin in patients with advanced gastric cancer: a randomised, multicentre, open-label, phase 2 trial.2016
- Author(s)
  Hironaka S, Sugimoto N, Yamaguchi K, Moriwaki T, Komatsu Y, Nishina T, Tsuji A, Nakajima TE, Gotoh M, Machida N, Bando H, Esaki T, Emi Y, Sekikawa T, Matsumoto S, Takeuchi M, Boku N, Baba H, Hyodo I
- Journal Title
  
  Lancet Oncol
  
  Volume: 17 Issue: 1 Pages: 99-108
- DOI
  10.1016/s1470-2045(15)00410-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460933
[Journal Article] EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition.2015
- Author(s)
  Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K, Terashita K, Suda G, Ohnishi S, Shimizu Y, Komatsu Y, Ohashi S, Kagawa S, Kinugasa H, Whelan KA, Nakagawa H, Sakamoto N.
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 16 Issue: 6 Pages: 933940-933940
- DOI
  10.1080/15384047.2015.1040959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-25460921
[Journal Article] Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients2015
- Author(s)
  Sasaki T, Fuse N, Kuwata T, Nomura S, Kaneko K, Doi T, Yoshino T, Asano H, Ochiai A, Komatsu Y, Sakamoto N, Ohtsu A
- Journal Title
  
  Jpn. J. Clin. Oncol
  
  Volume: 45 Issue: 1 Pages: 43-48
- DOI
  10.1093/jjco/hyu174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460921
[Journal Article] A pivotal role of Krüppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma.2015
- Author(s)
  Maehara O, Sato F, Natsuizaka M, Asano A, Kubota Y, Itoh J, Tsunematsu S, Terashita K, Tsukuda Y, Nakai M, Sho T, Suda G, Morikawa K, Ogawa K, Chuma M, Nakagawa K, Ohnishi S, Komatsu Y, Whelan KA, Nakagawa H, Takeda H, Sakamoto N.
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 16 Issue: 10 Pages: 14531461-14531461
- DOI
  10.1080/15384047.2015.1070992
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08943, KAKENHI-PROJECT-15K08980, KAKENHI-PROJECT-26460933, KAKENHI-PROJECT-26461021
[Presentation] HGCSG1803　膵癌一次治療Oxaliplatin/Irinotecan/S-1併用療法(OX-IRIS)の第II相試験2023
- Author(s)
  中野真太郎, 川本泰之, 澤田憲太郎, 宮城島拓人, 曽我部進, 小林良充, 伊藤憲, 佐藤温, 陳豫, 太宰昌佳, 原田一顕, 結城敏志, 横田勲, 小松嘉人
- Organizer
  第61回　日本癌治療学会
- Data Source
  KAKENHI-PROJECT-22K08023
[Presentation] 実臨床における切除不能進行・再発胆道癌に対するGEM+CDDP+S-1療法(GCS)と三剤逐次投与のの治療成績に関する検討2023
- Author(s)
  川本泰之, 原田一顕, 坂本直哉, 中村赳晶, 金子志帆, 石田浩一, 結城敏志, 桑谷将城, 小松嘉人
- Organizer
  第59回　日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08023
[Presentation] EGFR inhibitors suppress epithelial-mesenchymal transition and diminish cancer stem-like cells in esophageal squamous cell carcinoma
- Author(s)
  Fumiyuki Sato, Mitsuteru Natsuizaka, Shinya Ohashi, Shingo Kagawa, Masaki Kuwatai, Hiroshi Kawakami, Shunsuke Ohnishi, Yoshito Komatsu, Mototsugu Kato, Naoya Sakamoto
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26460933

1. Kobayashi Takahiko (80333607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 夏井坂光輝 (80642446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 川久保和道 (80633578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 須田剛生 (20447460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MAEHARA Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. MIZUNO Nobumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Komatsu Yoshito 小松 嘉人

小松 嘉人 コマツ ヨシト

KOMATSU YOSHITO 小松 嘉人

Research Projects

Research Products

Co-Researchers

PARP inhibitor resistance in cancer stem cells in hepatocelular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cancer stem cell niche by using esophageal orgnotypic 3D culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation of UGT1A1 Gene Polymorphisms or Prior Irinotecan Treatment and Treatment Outcomes of Nanoliposomal-Irinotecan plus 5-Fluorouracil/Leucovorin for Pancreatic Ductal Adenocarcinoma: A Multicenter, Retrospective Cohort Study (HGCSG2101)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of an optimal mutant allele frequency to detect activating KRAS, NRAS, and BRAF mutations in a commercial cell-free DNA next-generation sequencing assay in colorectal and pancreatic adenocarcinomas2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-epidermal growth factor receptor treatment for patients with Neo RAS wild-type metastatic colorectal cancer: a case report of two cases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A randomised phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel for locally advanced pancreatic cancer (JCOG1407)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase I Study of the Liposomal Formulation of Eribulin (E7389-LF): Results from the Advanced Gastric Cancer Expansion Cohort2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Feasibility of edoxaban for asymptomatic cancer-associated thrombosis in Japanese patients with gastrointestinal cancer: ExCAVE study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the Pancreatic Cancer Microbiome Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration-Derived Samples2022

Komatsu Yoshito 小松嘉人

小松嘉人コマツヨシト

KOMATSU YOSHITO 小松嘉人

[Journal Article] A pivotal role of Krüppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma.2015

[Presentation] HGCSG1803　膵癌一次治療Oxaliplatin/Irinotecan/S-1併用療法(OX-IRIS)の第II相試験2023