Akiba Hisaya 秋葉久弥

… Alternative Names

秋葉久弥アキバヒサヤ

AKIBA Hisaya 秋葉久弥

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Researcher Number	60338316
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 准教授 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授 2012 – 2018: 順天堂大学, 医学(系)研究科(研究院), 准教授 2016: 順天堂大学, 大学院医学研究科, 准教授 2012 – 2013: 順天堂大学, 医学研究科, 准教授 … More 2007 – 2011: Juntendo University, Immunology, Associate professor 2010: 順天堂大学, 大学院・医学研究科, 准教授 2005 – 2006: Juntendo University, Immunology, Assistant Prof., 医学部, 講師 2002 – 2004: 順天堂大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Collagenous pathology/Allergology / Basic Section 49030:Experimental pathology-related / アレルギー / 膠原病・アレルギー・感染症内科学 / Ophthalmology / Immunology Except Principal Investigator 膠原病・アレルギー・感染症内科学 / Ophthalmology / Experimental pathology / Immunology / Biological Sciences
Keywords	Principal Investigator アレルギー / 喘息 / 自己免疫疾患 / B7RP-1 / ICOS / OX40L / OX40 / 補助シグナル分子 / Th2 / Th1 … More / 免疫学 / 診断薬 / 炎症 / 免疫 / CXCR5 / アレルギー疾患 / T細胞分化 / 関節リウマチ / アレルギー・ぜんそく / ぜんそく / monoclonal antibody / T cell differentiation / 喘息疾患 / Tim family / Tim ligand / Tim / モノクローナル抗体 / 細胞表面分子 / 細胞表面分子機能 / 抗炎症作用 / コラーゲン誘発性関節炎マウス / CD70-CD27 / 関節炎マウス / TIM-4 / 関節炎モデルマウス / 喘息モデルマウス / Th1/Th2 / OX40-OX40L / EAU / 実験的自己免疫性ぶどう膜網膜炎 / T細胞分化・制御 / 樹状細胞 … More Except Principal Investigator 自己免疫疾患 / コラーゲン誘発性関節炎 / Tim-3 / アポトーシス / histone deacetylase inhibitor / DR5 / TRAIL / トレランス / CD8α^+樹状細胞 / ICOS/B7RP-1 / VISTAシグナル / ICOS/B7RP-1(ICOSL) / 移植免疫応答 / 副刺激シグナル / 免疫特権 / アレルギー・ぜんそく / 炎症 / アレルギー疾患 / 免疫学 / TNF-TNFR family / CD28-B7 family / costimulatory molecules / experimental autoimmune encephalomyelitis / murine model of asthma / experimental autoimmune uveoretinitis / collagen-induced arthritis / autoimmune diseases / TWEAK / B7RP-1 / TNF-TNFRファミリー / CD28-B7ファミリー / 補助シグナル分子 / 実験的自己免疫性脳脊髄炎 / OVA誘発性喘息 / 実験的自己免疫性ぶどう膜網膜炎 / 関節炎モデル / 抗炎症作用 / TIM-4 / アレルギー・喘息 / アレルギー･喘息 / 喘息 / 抗体療法 / 関節リウマチ / bortezomib / HER2 / Erb-2 / IL-15 / CD137 / CD40 / NK細胞 / 中皮腫 / ADCC / mesotheli / C-ERC / CTLA-4 / CTL / 所属リンパ節 / regulatory T細胞 / 免疫抑制 / 免疫活性化 / 細胞死 / 癌治療 / 腫瘍免疫 / 免疫監視 / クロスプレゼンテーション / 貪食 / 樹状細胞 / CD63 / IgE / 脱顆粒 / ノックアウトマウス / Liht chain(LC)3 / インターフェロン / オートファジー / Th17細胞 / Th2細胞 / Th1細胞 / T細胞 / B細胞 / TIM-2 / T cell immunoglobulin and mucin domain (TIM)ファミリー / アレルギー / マスト細胞 / TIMファミリー / ErbB-2(HER2) / 原発性硬化性胆管炎(PSC) Less

Functional analysis of TIM molecules that regulate the pathogenesis of autoimmune and allergic diseasesPrincipal Investigator
- Principal Investigator
  
  Akiba Hisaya
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Juntendo University
Detection of human TIM-4 on autoimmune and allergic diseasesPrincipal Investigator
- Principal Investigator
  
  Akiba Hisaya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Immune regulation on autoimmune and allergic diseases by the TIM family molecules
- Principal Investigator
  
  Okumura Ko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Immune regulation for tissue transplantation and regeneration in the eye
- Principal Investigator
  
  Hori Junko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Nippon Medical School
Analysis of therapeutic effect of anti-TIM-4 mAb on inflammatory disease.Principal Investigator
- Principal Investigator
  
  Akiba Hisaya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule markerPrincipal Investigator
- Principal Investigator
  
  AKIBA Hisaya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
免疫による癌拒絶局所での分子機構の解析
- Principal Investigator
  
  KAZUYOSHI Takeda
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Development of strategy to treat allergic diseases via targeting surface molecules on lymphocytes and intracellular signaling molecules
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Development of novel cancer therapy by combination of immune activation with tumor apoptosis induction
- Principal Investigator
  
  KAZUYOSHI Takeda
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
Functional analysis of costimulatory molecules in autoimmune uveitis and their intervention for clinical applicationPrincipal Investigator
- Principal Investigator
  
  AKIBA Hisaya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Juntendo University
Functional analysis of costimulatory molecules for autoimmune diseases
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Identification of Th cells in vivo and analysis of differentiation and function of Th2 cells by costimulatory moleculesPrincipal Investigator
- Principal Investigator
  
  AKIBA Hisaya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  アレルギー
- Research Institution
  JUNTENDO UNIVERSITY
Th2細胞の分化・機能に関わる補助シグナル分子の解明Principal Investigator
- Principal Investigator
  
  秋葉久弥
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University

[Journal Article] A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines2023
- Author(s)
  Tsuchiya Y, Komazawa-Sakon S, Tanaka M, Kanokogi T, Moriwaki K, Akiba H, Yagita H, Okumura K, Entzminger K.C., Okumura C.J., Maruyama T, Nakano H
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 675 Pages: 71-77
- DOI
  10.1016/j.bbrc.2023.06.070
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06489, KAKENHI-PROJECT-20H03472, KAKENHI-PROJECT-23K24097, KAKENHI-PROJECT-23K27398
[Journal Article] MAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model2023
- Author(s)
  Sandhu Yuuki、Harada Norihiro、Harada Sonoko、Nishimaki Takayasu、Sasano Hitoshi、Tanabe Yuki、Takeshige Tomohito、Matsuno Kei、Ishimori Ayako、Katsura Yoko、Ito Jun、Akiba Hisaya、Takahashi Kazuhisa
- Journal Title
  
  Current Issues in Molecular Biology
  
  Volume: 45 Issue: 11 Pages: 8907-8924
- DOI
  10.3390/cimb45110559
- Data Source
  KAKENHI-PROJECT-20H03472
[Journal Article] Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma2023
- Author(s)
  Sandhu Yuuki、Harada Norihiro、Sasano Hitoshi、Harada Sonoko、Ueda Shoko、Takeshige Tomohito、Tanabe Yuki、Ishimori Ayako、Matsuno Kei、Abe Sumiko、Nagaoka Tetsutaro、Ito Jun、Chiba Asako、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Miyake Sachiko、Takahashi Kazuhisa
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 3 Pages: 538-538
- DOI
  10.3390/biom13030538
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02964, KAKENHI-PROJECT-20K08549, KAKENHI-PROJECT-20K08807, KAKENHI-PROJECT-23K07658, KAKENHI-PROJECT-21K08476, KAKENHI-PROJECT-20H03472
[Journal Article] Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen2022
- Author(s)
  Ueda Shoko、Ito Jun、Harada Norihiro、Harada Sonoko、Sasano Hitoshi、Sandhu Yuuki、Tanabe Yuki、Abe Sumiko、Shiota Satomi、Kodama Yuzo、Nagaoka Tetsutaro、Makino Fumihiko、Chiba Asako、Akiba Hisaya、Atsuta Ryo、Miyake Sachiko、Takahashi Kazuhisa
- Journal Title
  
  Biomolecules
  
  Volume: 12 Issue: 4 Pages: 518-518
- DOI
  10.3390/biom12040518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08549, KAKENHI-PROJECT-20H03472
[Journal Article] Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice2021
- Author(s)
  Takeshige Tomohito、Harada Norihiro、Harada Sonoko、Ishimori Ayako、Katsura Yoko、Sasano Hitoshi、Sandhu Yuuki、Matsuno Kei、Makino Fumihiko、Ito Jun、Atsuta Ryo、Akiba Hisaya、Takahashi Kazuhisa
- Journal Title
  
  Allergology International
  
  Volume: 70 Issue: 3 Pages: 343-350
- DOI
  10.1016/j.alit.2020.12.004
- NAID
  130008064045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08549, KAKENHI-PROJECT-20H03472
[Journal Article] Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation2021
- Author(s)
  Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, Nakayama M
- Journal Title
  
  Cell reports
  
  Volume: 34 Issue: 6 Pages: 108734-108734
- DOI
  10.1016/j.celrep.2021.108734
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-15H05785, KAKENHI-PLANNED-17H06415, KAKENHI-PROJECT-19H03371, KAKENHI-PROJECT-19H03880, KAKENHI-PROJECT-19K22808, KAKENHI-PROJECT-18KK0229, KAKENHI-PROJECT-20H03472, KAKENHI-ORGANIZER-17H06413
[Journal Article] Blockade of costimulatory CD27/CD70 pathway promotes corneal allograft survival2020
- Author(s)
  Narimatsu A, Hattori T, Hiroki Ueno et al
- Journal Title
  
  Experimental eye research
  
  Volume: 199 Pages: 108190-108190
- DOI
  10.1016/j.exer.2020.108190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09463, KAKENHI-PROJECT-19K09959, KAKENHI-PROJECT-20H03472, KAKENHI-PROJECT-19K18892
[Journal Article] ImmunoPET Imaging of TIM-3 in Murine Melanoma Models.2020
- Author(s)
  Wei W, Jiang D, Lee HJ, Engle JW, Akiba H, Liu J, Cai W.
- Journal Title
  
  Adv Ther
  
  Volume: 3 Issue: 7 Pages: 2000018-2000018
- DOI
  10.1002/adtp.202000018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03472
[Journal Article] Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition2018
- Author(s)
  Matsuno Kei、Harada Norihiro、Harada Sonoko、Takeshige Tomohito、Ishimori Ayako、Itoigawa Yukinari、Katsura Yoko、Kodama Yuzo、Makino Fumihiko、Ito Jun、Atsuta Ryo、Akiba Hisaya、Takahashi Kazuhisa
- Journal Title
  
  Experimental Lung Research
  
  Volume: 44 Issue: 7 Pages: 332-343
- DOI
  10.1080/01902148.2018.1522558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16K09924
[Journal Article] Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E2018
- Author(s)
  Yasuda Mina、Harada Norihiro、Harada Sonoko、Ishimori Ayako、Katsura Yoko、Itoigawa Yukinari、Matsuno Kei、Makino Fumihiko、Ito Jun、Ono Junya、Tobino Kazunori、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Takahashi Kazuhisa
- Journal Title
  
  Allergy, Asthma & Clinical Immunology
  
  Volume: 14 Issue: 1 Pages: 72-72
- DOI
  10.1186/s13223-018-0300-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05343, KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16K09924
[Journal Article] Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice.2017
- Author(s)
  Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S.
- Journal Title
  
  J Immunol
  
  Volume: 199 Issue: 11 Pages: 3733-3737
- DOI
  10.4049/jimmunol.1700059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09554, KAKENHI-PROJECT-16K09587, KAKENHI-PROJECT-16H02960, KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-16K15112, KAKENHI-PROJECT-16K09924
[Journal Article] Protective role of ICOS and ICOS Ligand in corneal transplantation and in maintenance of immune privilege2016
- Author(s)
  Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 57(15) Issue: 15 Pages: 6815-6823
- DOI
  10.1167/iovs.16-20644
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462700, KAKENHI-PROJECT-15K20290, KAKENHI-PROJECT-16K09924
[Journal Article] OX40L blockade protects against inflammation-driven fibrosis.2016
- Author(s)
  Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Frechet M, Burgevin A, Pezet S, Sadoine J, Guilbert T, Nicco C, Akiba H, Heissmeyer V, Subramaniam A, Resnick R, Molberg O, Kahan A, Chiocchia G, Allanore Y.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Issue: 27
- DOI
  10.1073/pnas.1523512113
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Journal Article] ICOS promotes group 2 innate lymphoid cell activation in lungs2015
- Author(s)
  Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 463 Issue: 4 Pages: 739-745
- DOI
  10.1016/j.bbrc.2015.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293234
[Journal Article] Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.2015
- Author(s)
  Tripathi S, Chabtini L, Dakle PJ, Smith B, Akiba H, Yagita H, Guleria I.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 4 Pages: e0123439-e0123439
- DOI
  10.1371/journal.pone.0123439
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461503
[Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation2015
- Author(s)
  1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
- Journal Title
  
  Experimental Lung Research
  
  Volume: 41 Issue: 7 Pages: 370-382
- DOI
  10.3109/01902148.2015.1044137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293087
[Journal Article] OX40 ligand regulates splenic CD8- dendritic cell-induced Th2 responses in vivo.2014
- Author(s)
  Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 444 Issue: 2 Pages: 235-240
- DOI
  10.1016/j.bbrc.2014.01.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390261, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293087
[Journal Article] Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease MRL-Fas(lpr) mice.2014
- Author(s)
  Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, Matsumura I.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 306 Issue: 10 Pages: F1210-F1221
- DOI
  10.1152/ajprenal.00570.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461503
[Journal Article] The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease.2014
- Author(s)
  Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS.
- Journal Title
  
  Int Immunol
  
  Volume: 26 Issue: 7 Pages: 369-81
- DOI
  10.1093/intimm/dxt056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461503
[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013
- Author(s)
  Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
- Journal Title
  
  J Immunol
  
  Volume: 191 Pages: 4562-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390260
[Journal Article] TIM-3 regulates innate immune cells to induce fetomaternal tolerance.2013
- Author(s)
  Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I.
- Journal Title
  
  J Immunol
  
  Volume: 190 Issue: 1 Pages: 88-96
- DOI
  10.4049/jimmunol.1202176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461503
[Journal Article] T-cell immunoglobulin and mucin domain 3 acts as a negative regulator of atherosclerosis.2013
- Author(s)
  Foks AC, Ran IA, Wasserman L, Frodermann V, Ter Borg MN, de Jager SC, van Santbrink PJ, Yagita H, Akiba H, Bot I, Kuiper J, van Puijvelde GH.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 33 Issue: 11 Pages: 2558-65
- DOI
  10.1161/atvbaha.113.301879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461503
[Journal Article] Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival2013
- Author(s)
  Yeung M, McGrath M, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka L, and Najafian N
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 8 Pages: 4447-4455
- DOI
  10.4049/jimmunol.1300992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590158, KAKENHI-PUBLICLY-25118703, KAKENHI-PROJECT-25461503
[Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis2013
- Author(s)
  Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
- Journal Title
  
  Journal of Immunology
  
  Volume: 191巻 Issue: 9 Pages: 4562-4572
- DOI
  10.4049/jimmunol.1203035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390260, KAKENHI-PROJECT-25461503
[Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013
- Author(s)
  Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
- Journal Title
  
  Immunity
  
  Volume: 39 Issue: 6 Pages: 1070-1081
- DOI
  10.1016/j.immuni.2013.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24790479, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25461503
[Journal Article] Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas2013
- Author(s)
  Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 62 Issue: 4 Pages: 629-637
- DOI
  10.1007/s00262-012-1371-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25461503
[Journal Article] Galectin- 9- mediated protection from allo- specific T cells as a mechanism of immune privilege of corneal allografts2013
- Author(s)
  Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J.
- Journal Title
  
  PLoS One
  
  Volume: 8 (5) Issue: 5 Pages: e63620-e63620
- DOI
  10.1371/journal.pone.0063620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592619, KAKENHI-PROJECT-25461503
[Journal Article] Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus.2013
- Author(s)
  Takahashi N, Imanishi K, Uchiyama T
- Journal Title
  
  Microbiol Immunol
  
  Volume: 57 Issue: 3 Pages: 737-745
- DOI
  10.1016/j.immuni.2013.06.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22390215, KAKENHI-PROJECT-23591412, KAKENHI-PROJECT-25461503
[Journal Article] Blockade of CD70-CD27 Interaction Inhibits Induction of Allergic Lung Inflammation in Mice2012
- Author(s)
  Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H
- Journal Title
  
  American journal of respiratory cell and molecular biology
  
  Volume: 47 Issue: 3 Pages: 298-305
- DOI
  10.1165/rcmb.2011-0354oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
[Journal Article] TIM-1 signaling in B cells regulates antibody production2012
- Author(s)
  Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, Akiba H
- Journal Title
  
  iochem Biophys Res Commun
  
  Volume: 406 Issue: 2 Pages: 223-228
- DOI
  10.1016/j.bbrc.2011.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
[Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes.2012
- Author(s)
  Kanzaki M
- Journal Title
  
  Endocrinology
  
  Volume: 153(2) Issue: 2 Pages: 612-620
- DOI
  10.1210/en.2011-1579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249053, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390241, KAKENHI-PROJECT-23659470, KAKENHI-PROJECT-24790926, KAKENHI-PUBLICLY-23126516
[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. S.2012
- Author(s)
  Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 13 Issue: 9 Pages: 832-842
- DOI
  10.1038/ni.2376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
[Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects2012
- Author(s)
  Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
- Journal Title
  
  Hybridoma
  
  Volume: 31 Issue: 1 Pages: 40-47
- DOI
  10.1089/hyb.2011.0087
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021016, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23249082, KAKENHI-PROJECT-23390260
[Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development2012
- Author(s)
  Sugiyama, et al.
- Journal Title
  
  International Immunology
  
  Volume: 24 Issue: 6 Pages: 369-378
- DOI
  10.1093/intimm/dxs002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591375, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
[Journal Article] EndogenousTim-1 promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis2012
- Author(s)
  ozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H,Holdsworth SR, Kitching AR
- Journal Title
  
  Kidney international
  
  Volume: 81 Issue: 9 Pages: 844-855
- DOI
  10.1038/ki.2011.424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011
- Author(s)
  Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 2
- DOI
  10.1186/ar3288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390260
[Journal Article] Wound-induced TGF-γ1 and TGF-γ2 enhance airway epithelial repair via HB-EGF and TGF-α.2011
- Author(s)
  Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 412 Issue: 1 Pages: 109-114
- DOI
  10.1016/j.bbrc.2011.07.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-22790768, KAKENHI-PROJECT-23390260
[Journal Article] Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.2011
- Author(s)
  Kawamoto T., Y.Abe, J.Ito, F.Makino, Y.Kojima, Y.Usui, J.Ma, S.Morimoto, H.Yagita, K.Okumura, Y.Takasaki, H.Akiba.
- Journal Title
  
  Arthritis Res Ther 13(in press)
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] Anti-TIM3 antibody promotes T cell IFN-γ-mediated anti-tumor immunity and suppresses established tumors2011
- Author(s)
  Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ
- Journal Title
  
  Cancer Res
  
  Volume: 71 Issue: 10 Pages: 3540-3551
- DOI
  10.1158/0008-5472.can-11-0096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22591098
[Journal Article] Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice2011
- Author(s)
  Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Issue: 9 Pages: 3645-3656
- DOI
  10.1172/jci46274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Tim-1 promotes cisplatin nephrotoxicity2011
- Author(s)
  Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 301 Issue: 5 Pages: F1098-F1104
- DOI
  10.1152/ajprenal.00193.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury2011
- Author(s)
  Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, Haller H, Najafian N, Habicht A
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 22 Issue: 3 Pages: 484-495
- DOI
  10.1681/asn.2010030321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Expression and function of inducible costimulator on peripheral blood CD4+T cells in Behcet's patients with uveitis: a new activity marker?2010
- Author(s)
  Usui Y, Takeuchi M, Yamakawa N, Takeuchi A, Kezuka T, Ma J, Matsuda R, Okunuki Y, Akiba H, Goto H
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 51 Issue: 10 Pages: 5099-5104
- DOI
  10.1167/iovs.10-5286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] IM-3: a novel regulatory molecule of alloimmune activation2010
- Author(s)
  Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
- Journal Title
  
  J Immunol
  
  Volume: 185 Issue: 10 Pages: 5806-5819
- DOI
  10.4049/jimmunol.0903435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse.2010
- Author(s)
  Uchida Y., B.Ke, M.C.Freitas, H.Ji, D.Zhao, E.R.Benjamin, N.Najafian, H.Yagita, H.Akiba, R.W.Busuttil, J.W.Kupiec-Weglinski
- Journal Title
  
  Hepatology 51
  
  Pages: 1363-1372
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] TIM-3 : a novel regulatory molecule of alloimmune activation.2010
- Author(s)
  Boenisch O., F.D'Addio, T.Watanabe, W.Elyaman, C.N.Magee, M.Y.Yeung, R.F.Padera, S.J.Rodig, T.Murayama, K.Tanaka, X.Yuan, T.Ueno, A.Jurisch, B.Mfarrej, H.Akiba, H.Yagita, N.Najafian
- Journal Title
  
  J Immunol 185
  
  Pages: 5806-5819
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] The emerging role of TIM-1 in the mechanism of liver ischemia and reperfusion injury in the mouse2010
- Author(s)
  Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW
- Journal Title
  
  Hepatolog
  
  Volume: 51 Issue: 4 Pages: 1363-1372
- DOI
  10.1002/hep.23442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Contribution of B7RP-1/ICOS co-stimulation to lethal acute GVHD2010
- Author(s)
  Fujimura J, Takeda K, Kaduka Y, Saito M, Akiba H, Yagita H, Yamashiro Y, Shimizu T, Okumura K
- Journal Title
  
  Pediatr Transplant
  
  Volume: 14 Issue: 4 Pages: 540-548
- DOI
  10.1111/j.1399-3046.2009.01279.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptors.2010
- Author(s)
  Takamura S., S.Tsuji-Kawahara, H.Yagita, H.Akiba, M.Sakamoto, T.Chikaishi, M.Kato, M.Miyazawa
- Journal Title
  
  J Immunol 184
  
  Pages: 4696-4707
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner.2010
- Author(s)
  Uchida Y., B.Ke, M.C.Freitas, H.Yagita, H.Akiba, R.W.Busuttil, N.Najafian, J.W.Kupiec-Weglinski
- Journal Title
  
  Gastroenterology 139
  
  Pages: 2195-2206
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b : LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.2010
- Author(s)
  Yamanishi Y., J.Kitaura, K.Izawa, A.Kaitani, Y.Komeno, M.Nakamura, S.Yamazaki, Y.Enomoto, T.Oki, H.Akiba, T.Abe, T.Komori, Y.Morikawa, H.Kiyonari, T.Takai, K.Okumura, T.Kitamura
- Journal Title
  
  J Exp Med 207
  
  Pages: 1501-1511
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury2010
- Author(s)
  Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
- Journal Title
  
  J Exp Med
  
  Volume: 207 Issue: 7 Pages: 1501-1511
- DOI
  10.1084/jem.20090581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] TIM-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner2010
- Author(s)
  Uchida Y, Ke B, Freitas MC, Yagita H,Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW
- Journal Title
  
  Gastroenterology
  
  Volume: 139 Issue: 6 Pages: 2195-2206
- DOI
  10.1053/j.gastro.2010.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591098
[Journal Article] Premature terminal exhaustion of Friend virus-specific effector CD8^+T cells by rapid induction of multiple inhibitory receptors2010
- Author(s)
  Takamura, S., S. Tsuji-Kawahara, H. Yagita, H. Akiba, M. Sakamoto, T. Chikaishi, M. Kato, M. Miyazawa
- Journal Title
  
  J. Immunol
  
  Volume: 184 Issue: 9 Pages: 4696-4707
- DOI
  10.4049/jimmunol.0903478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390143, KAKENHI-PROJECT-22591098
[Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009
- Author(s)
  Nakano, N., C. Nishiyama, H. Yagita, A. Koyanagi, H. Akiba, S. Chiba, H. Ogawa, and K. Okumura
- Journal Title
  
  J Allergy Clin Immunol 123
  
  Pages: 74-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+ CD25+ regulatory T cells in chronic colitis2009
- Author(s)
  Totsuka, T., T. Kanai, Y. Nemoto, T. Tomita, R. Okamoto, K. Tsuchiya, T. Nakamura, N. Sakamoto, H. Akiba, K. Okumura, H. Yagita, and M. Watanabe.
- Journal Title
  
  J Immunol 182
  
  Pages: 6079-6087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation2009
- Author(s)
  Nakayama, M., H. Akiba, K. Takeda, Y. Kojima, M. Hashiguchi, M. Azuma, H. Yagita, and K. Okumura
- Journal Title
  
  Blood 113
  
  Pages: 3821-3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells.2009
- Author(s)
  Nakano N., C.Nishiyama, H.Yagita, A.Koyanagi, H.Akiba, S.Chiba, H.Ogawa, K.Okumura
- Journal Title
  
  J Allergy Clin Immunol 123
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.2009
- Author(s)
  Totsuka T., T.Kanai, Y.Nemoto, T.Tomita, R.Okamoto, K.Tsuchiya, T.Nakamura, N.Sakamoto, H.Akiba, K.Okumura, H.Yagita, M.Watanabe
- Journal Title
  
  J Immunol 182
  
  Pages: 6079-6087
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.2009
- Author(s)
  Nakayama M., Akiba H., Takeda K., 他
- Journal Title
  
  Blood 113
  
  Pages: 3821-3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590494
[Journal Article] RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.2009
- Author(s)
  Knoop K.A., N.Kumar, B.R.Butler, S.K.Sakthivel, R.T.Taylor, T.Nochi, H.Akiba, H.Yagita, H.Kiyono, I.R.Williams
- Journal Title
  
  J Immunol 183
  
  Pages: 5738-5747
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice2009
- Author(s)
  Usui, Y., M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto.
- Journal Title
  
  Arch Ophthalmol 127
  
  Pages: 514-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.2009
- Author(s)
  Nakayama M., H.Akiba, K.Takeda, Y.Kojima, M.Hashiguchi, M.Azuma, H.Yagita, K.Okumura
- Journal Title
  
  Blood 113
  
  Pages: 3821-3830
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.2009
- Author(s)
  Yuan X., M.J.Ansari, F.D'Addio, J.Paez-Cortez, I.Schmitt, M.Donnarumma, O.Boenisch, X.Zhao, J.Popoola, M.R.Clarkson, H.Yagita, H.Akiba, G.J.Freeman, J.Iacomini, L.A.Turka, L.H.Glimcher, M.H.Sayegh
- Journal Title
  
  Proc Natl Acad Sci U S A 106
  
  Pages: 10734-10739
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.2008
- Author(s)
  Ueno T., A.Habicht, M.R.Clarkson, M.J.Albin, K.Yamaura, O.Boenisch, J.Popoola, Y.Wang, H.Yagita, H.Akiba, M.J.Ansari, J.Yang, L.A.Turka, D.M.Rothstein, R.F.Padera, N.Najafian, M.H.Sayegh
- Journal Title
  
  J Clin Invest 118
  
  Pages: 742-751
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis2008
- Author(s)
  Wong, M. G., Y. Suzuki, C. Tanifuji, H. Akiba, K. Okumura, T. Sugaya, T. Yamamoto, S. Horikoshi, S. Y. Tan, C. Pollock, and Y. Tomino.
- Journal Title
  
  J Am Soc Nephrol 19
  
  Pages: 290-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice2008
- Author(s)
  Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno.
- Journal Title
  
  Int Arch Allergy Immunol 146
  
  Pages: 36-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model2008
- Author(s)
  Ueno, T., A. Habicht, M. R. Clarkson, M. J. Albin, K. Yamaura, O. Boenisch, J. Popoola, Y. Wang, H. Yagita, H. Akiba, M. J. Ansari, J. Yang, L. A. Turka, D. M. Rothstein, R. F. Padera, N. Najafian, and M. H. Sayegh
- Journal Title
  
  J Clin Invest 118
  
  Pages: 742-751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma.2008
- Author(s)
  Nagashima O., N.Harada, Y.Usui, T.Yamazaki, H.Yagita, K.Okumura, K.Takahashi, H.Akiba
- Journal Title
  
  J Immunol 181
  
  Pages: 4062-4071
- Data Source
  KAKENHI-PROJECT-20390282
[Journal Article] B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma2008
- Author(s)
  Nagashima, O., N. Harada, Y. Usui, T. Yamazaki, H. Yagita, K. Okumura, K. Takahashi, and H. Akiba
- Journal Title
  
  J Immunol 181
  
  Pages: 4062-4071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine2008
- Author(s)
  Chen, Q., J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper
- Journal Title
  
  J Immunol 181
  
  Pages: 8258-8266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, H., Akiba, K., Okumura, H., Yagita, H., Ueno
- Journal Title
  
  Biochemical and biophysical research communications 353
  
  Pages: 211-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis2007
- Author(s)
  Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 211-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007
- Author(s)
  Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, K. Okumura, H. Akiba, H. Yagita, and H. Ueno
- Journal Title
  
  Immunol Lett 110
  
  Pages: 133-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, K., Okumura, H., Akiba, H., Yagita, H., Ueno
- Journal Title
  
  Immunology letters 110
  
  Pages: 133-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival2007
- Author(s)
  Hattori, T., Y., Usui, Y., Okunuki, Y., Sonoda, M., Usui, E., Takada, J., Mizuguchi, H., Yagita, K., Okumura, H., Akiba, M., Takeuchi
- Journal Title
  
  European journal of immunology 37
  
  Pages: 3597-3604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival2007
- Author(s)
  Hattori, T., Y. Usui, Y. Okunuki, Y. Sonoda, M. Usui, E. Takada, J. Mizuguchi, H. Yagita, K. Okumura, H. Akiba, and M. Takeuchi
- Journal Title
  
  Eur J Immunol 37
  
  Pages: 3597-3604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007
- Author(s)
  Fukushima, A., T., Sumi, K., Fukuda, N., Kumagai, T., Nishida, T., Yamazaki, H., Akiba, K., Okumura, H., Yagita, H., Ueno
- Journal Title
  
  Immunology letters 113
  
  Pages: 52-57
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells2007
- Author(s)
  Nakae, S., M. Iikura, H. Suto, H. Akiba, D. T. Umetsu, R. H. Dekruyff, H. Saito, and S. J. Galli
- Journal Title
  
  Blood 110
  
  Pages: 2565-2568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function2007
- Author(s)
  Xiao, S., N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R. A. Sobel, D. T. Umetsu, H. Yagita, H. Akiba, T. Strom, M. H. Sayegh, R. H. DeKruyff, S. J. Khoury, and V. K. Kuchroo
- Journal Title
  
  J Exp Med 204
  
  Pages: 1691-1702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007
- Author(s)
  Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, T. Yamazaki, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
- Journal Title
  
  Immunol Lett 113
  
  Pages: 52-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592040
[Journal Article] Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease2006
- Author(s)
  Oikawa, T., Y., Kamimura, H., Akiba, H., Yagita, K., Okumura, H., Takahashi, M., Zeniya, H., Tajiri, M., Azuma
- Journal Title
  
  J lmmuno 1177
  
  Pages: 4281-4287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] 2006. Eradication of established tumors in mice by a combination antibody-based therapy2006
- Author(s)
  Uno, T., K., Takeda, Y., Kojima, H., Yoshizawa, H., Akiba, R. S., Mittler, F., Gejyo, K., Okumura, H., Yagita, M. J., Smyth
- Journal Title
  
  Nature medicine 12
  
  Pages: 693-698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody2006
- Author(s)
  Kamijo, S., A., Nakajima, K., Ikeda, K., Aoki, K., Ohya, H., Akiba, H., Yagita, K., Okumura
- Journal Title
  
  Biochemical and biophysical research communications 347
  
  Pages: 124-132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses2006
- Author(s)
  Kikuchi, Y., T., Takai, T., Kuhara, M., Ota, T., Kato, H., Hatanaka, S., Ichikawa, T., Tokura, H., Akiba, K., Mitsuishi, S., Ikeda, K., Okumura, H., Ogawa
- Journal Title
  
  J lmmunol 177
  
  Pages: 1609-1617
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Journal Article] TIMファミリー分子2005
- Author(s)
  秋葉久弥
- Journal Title
  
  炎症と免疫 13
  
  Pages: 34-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.2005
- Author(s)
  Akiba, H., K.Takeda, Y.Kojima, Y.Usui, N.Harada, T.Yamazaki, J.Ma, K.Tezuka, H.Yagita, K.Okumura.
- Journal Title
  
  J Immunol 175
  
  Pages: 2340-2348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.2005
- Author(s)
  Ota, T., K.Takeda, H.Akiba, Y.Hayakawa, K.Ogasawara, Y.Ikarashi, S.Miyake, H.Wakasugi, T.Yamamura, M.Kronenberg, D.H.Raulet, K.Kinoshita, H.Yagita, M.J.Smyth, K.Okumura.
- Journal Title
  
  Blood 106
  
  Pages: 184-192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.2005
- Author(s)
  Takeda, K., E.Cretney, Y.Hayakawa, T.Ota, H.Akiba, K.Ogasawara, H.Yagita, K.Kinoshita, K.Okumura, M.J.Smyth.
- Journal Title
  
  Blood 105
  
  Pages: 2082-2089
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.2005
- Author(s)
  Miyahira, Y., Y.Takashima, S.Kobayashi, Y.Matsumoto, T.Takeuchi, M.Ohyanagi-Hara, A.Yoshida, A.Ohwada, H.Akiba, H.Yagita, K.Okumura, H.Ogawa.
- Journal Title
  
  Infect Immun 73
  
  Pages: 7356-7365
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production.2005
- Author(s)
  Yamazaki, T., H.Akiba, A.Koyanagi, M.Azuma, H.Yagita, K.Okumura.
- Journal Title
  
  J Immunol 175
  
  Pages: 1586-1592
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] リンパ球の活性化・機能調節とリンパ球機能分子2005
- Author(s)
  秋葉久弥
- Journal Title
  
  日本臨牀増刊号臨床免疫学(上) 63
  
  Pages: 34-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] The role of ICOS in the CXCR5^+ follicular B helper T cell maintenance in vivo.2005
- Author(s)
  Hisaya Akiba
- Journal Title
  
  The Journal of Immunology 175
  
  Pages: 2340-2348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation.2005
- Author(s)
  Tsukahara, R., M.Takeuchi, H.Akiba, T.Kezuka, K.Takeda, Y.Usui, M.Usui, H.Yagita, K.Okumura
- Journal Title
  
  Int Immunol 17
  
  Pages: 523-530
- NAID
  10019359132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells2005
- Author(s)
  Totsuka, T., T.Kanai, S.Makita, R.Fujii, Y.Nemoto, S.Oshima, R.Okamoto, A.Koyanagi, H.Akiba, K.Okumura, H.Yagita, M.Watanabe.
- Journal Title
  
  Eur J Immunol 35
  
  Pages: 1773-1785
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] ICOS costimulates invariant NKT cell activation.2005
- Author(s)
  Kaneda, H., K.Takeda, T.Ota, Y.Kaduka, H.Akiba, Y.Ikarashi, H.Wakasugi, M.Kroneneberg, K.Kinoshita, H.Yagita, K.Okumura.
- Journal Title
  
  Biochem Biophys Res Commun 327
  
  Pages: 201-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.2004
- Author(s)
  Cho, H.R., B.Kwon, H.Yagita, S.La, E.A.Lee, J.E.Kim, H.Akiba, J.Kim, J.H.Suh, D.S.Vinay, S.A.Ju, B.S.Kim, R.S.Mittler, K.Okumura, B.S.Kwon.
- Journal Title
  
  Transpl Int 17
  
  Pages: 351-361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.2004
- Author(s)
  Matsumoto, K., H.Inoue, T.Nakano, M.Tsuda, Y.Yoshiura, S.Fukuyama, F.Tsushima, T.Hoshino, H.Aizawa, H.Akiba, D.Pardoll, N.Hara, H.Yagita, M.Azuma, Y.Nakanishi.
- Journal Title
  
  J Immunol 172
  
  Pages: 2530-2541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.2004
- Author(s)
  Takeda, K., N.Yamaguchi, H.Akiba, Y.Kojima, Y.Hayakawa, J.E.Tanner, T.J.Sayers, N.Seki, K.Okumura, H.Yagita, M.J.Smyth.
- Journal Title
  
  J Exp Med 199
  
  Pages: 437-448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616008
[Journal Article] 2006. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
- Author(s)
  Usui, Y., H., Akiba, M., Takeuchi, T., Kezuka, A., Takeuchi, T., Hattori, Y., Okunuki, T., Yamazaki, H., Yagita, M., Usui, K., Okumura
- Journal Title
  
  European journal of immunology 36
  
  Pages: 3071-3081
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Presentation] Analysis of clinical utility of soluble TIM-4 in rheumatoid arthritis patient serum2024
- Author(s)
  Hisaya Akiba, Yoshiyuki Abe, Yoko Tabe, Naoto Tamura, Sachiko Miyake
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Circulating MAIT cells, neutrophils, and periostin as biomarkers for mepolizumab in asthmatics2023
- Author(s)
  Hitoshi Sasano, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, and Kazuhisa Takahashi
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Role of MAP3K19 in Allergic Airway Inflammation of Asthma2023
- Author(s)
  Yuuki Sandhu, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Simiko Abe, Shoko Ueda, Takayasu Nishimaki, Yoshihiko Sato, Takayasu Watanabe, Tomohito Takeshige, Kei Matsuno, Jun Ito, Hisaya Akiba, Kazuhisa Takahashi
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] TIM-4 regulates mast cell activation and allergic airway inflammation by binding to CD300b2023
- Author(s)
  田辺悠記、秋葉久弥、原田紀宏、原田園子、伊藤潤、蒲池史卓、三宅幸子、高橋和久
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] 培養気道上皮細胞とOVA誘発喘息マウスモデルにおけるMAP3K19の役割2022
- Author(s)
  三道ユウキ、原田紀宏、原田園子、笹野仁史、安部寿美子、上田翔子、西牧孝泰、佐藤良彦、渡邉敬康、竹重智仁、松野圭、伊藤潤、秋葉久弥、高橋和久
- Organizer
  東京呼吸器リサーチフォーラム
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] スギ花粉症合併喘息患者における舌下免疫療法による症状改善効果と末梢血リンパ球分画の変化2022
- Author(s)
  上田翔子、伊藤潤、原田園子、笹野仁史、三道ユウキ、田辺悠記、安部寿美子、渡邉敬康、佐藤良彦、西牧孝泰、牧野文彦、塩田智美、児玉裕三、長岡鉄太郎、千葉麻子、秋葉久弥、三宅幸子、熱田了、原田紀宏、高橋和久
- Organizer
  第88回臨床アレルギー研究会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Soluble TIM-4 levels in serum are associated with severe asthma phenotype.2022
- Author(s)
  Yuki Tanabe, Hisaya Akiba, Norihiro Harada, and Sachiko Miyake.
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] 末梢血中MAIT細胞、好中球、血清ぺリオスチンのメポリズマブ治療効果予測バイオマーカーとしての可能性2022
- Author(s)
  笹野仁史、原田紀宏、原田園子、竹重智仁、三道ユウキ、田辺悠記、石森絢、松野圭、長岡鉄太郎、伊藤　潤、千葉麻子、秋葉久弥、熱田了、出原賢治、三宅幸子、高橋和久
- Organizer
  第3回日本喘息学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Tim4による炭素微粒子の認識および炎症応答の解析2022
- Author(s)
  黒岩美希、山口慎一郎、加藤慶宜、秋葉久弥、中山勝文
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Soluble TIM-4 levels in serum are associated with severe asthma phenotype.2021
- Author(s)
  Y. Tanabe, H. Akiba, N. Harada, K. Matsuno, J. Ito, S. Miyake, K. Takahashi
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] Steroid-resistant airway inflammation in mice induced by chitin.2021
- Author(s)
  T. Takeshige, N. Harada, S. Harada, A. Ishimori, Y. Katsura, H. Sasano, Y. Sandhu, K. Matsuno, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] 気管支喘息患者における血中可溶性TIM-4濃度2020
- Author(s)
  田辺悠記、原田紀宏、原田園子、笹野仁史、三道ユウキ、松野圭、竹重智仁、牧野文彦、伊藤潤、熱田了、三宅幸子、高橋和久、秋葉久弥
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] 喘息モデルマウスにおけるキチン誘導性ステロイド抵抗性気道炎症の解析2020
- Author(s)
  竹重智仁、原田紀宏、石森絢子、松野圭、原田園子、笹野仁史、田辺悠記、三道ユウキ、桂蓉子、牧野文彦、伊藤潤、秋葉久弥、高橋和久
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03472
[Presentation] 気管支喘息のバイオマーカーとしての血清テネイシンC値の可能性2018
- Author(s)
  浅地美奈、原田紀宏、原田園子、石森絢子、桂蓉子、糸魚川幸成、松野圭、牧野文彦、伊藤潤、小野純也、飛野和則、秋葉久弥、熱田了、出原賢治、高橋和久
- Organizer
  第67回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Circulating levels of soluble TIM-4 in the patients with asthma2018
- Author(s)
  Yuki Tanabe, Hisaya Akiba, Norihiro Harada, Kei Matsuno, Jun Ito, Kazuhisa Takahashi, and Sachiko Miyake
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Circulating levels of tenascin-C as type 2 biomarkers in the patients with asthma2018
- Author(s)
  M. Asaji, N. Harada, S. Harada, A. Ishimori, Y. Katsura, Y. Itoigawa, K. Matsuno, F. Makino, J. Ito, J. Ono, K. Tobino, H. Akiba, R. Atsuta, K. Izuhara, K. Takahashi
- Organizer
  第58回日本呼吸器学会会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] 免疫チェックポイントTIMの慢性炎症における働き2018
- Author(s)
  秋葉久弥
- Organizer
  第36回呼吸器・免疫シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Chitin Induced Airway Inflammation and Production of Prostaglandin E22018
- Author(s)
  T. Takeshige, N. Harada, K. Matsuno, A. Ishimori, Y. Tanabe, H. Sasano, A. Nakamura, S. Harada, Y. Katsura, F. Makino, J. Ito, R. Atsuta, H. Akiba, K. Takahashi
- Organizer
  第58回日本呼吸器学会会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Expression of TIM-4 in normal cornea and corneal grafts2018
- Author(s)
  A. Takeda, H. Taniguchi, T. Kunishige, H. Akiba, H. Yagita, J. Hori
- Organizer
  The Annual Meeting of the Association for Research in Vision and Ophthalmology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] ヒト気道上皮細胞におけるキチンによるPGE2産生誘導2018
- Author(s)
  竹重智仁、原田紀宏、石森絢子、松野圭、原田園子、三道ユウキ、上田翔子、安部寿美子、中村愛、笹野仁史、田辺悠記、桂蓉子、牧野文彦、伊藤潤、秋葉久弥、熱田了、高橋和久
- Organizer
  第67回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] 上皮間葉転換が誘導された気道上皮細胞におけるケモカイン産生2017
- Author(s)
  松野圭, 原田紀宏, 石森絢子, 竹重智仁, 桂蓉子, 三道ユウキ, 中村愛, 笹野仁史, 田辺悠記, 牧野文彦, 伊藤潤, 熱田了, 秋葉久弥, 高橋和久
- Organizer
  第66回日本アレルギー学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Serum tenascin-C levels in patients with asthma2017
- Author(s)
  Norihiro Harada, Mina Asaji, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta1, Kenji Izuhara, and Kazuhisa Takahashi
- Organizer
  The 22nd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] The effect of mepolizumab treatment in patients with severe asthma2017
- Author(s)
  Yuuki Sandhu, Norihiro Harada, Kei Matsuno, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
- Organizer
  The 22nd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts2017
- Author(s)
  Taniguchi, H Hase, H Akiba, H Yagita, M Azuma
- Organizer
  ARVO 2017 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Baltimore, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] Chitin induced airway inflammation and production of prostaglandin E22017
- Author(s)
  Tomohito Takeshige, Norihiro Harada, Kei Matsuno, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
- Organizer
  The 22nd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Anti-TIM-3 treatment exacerbates pulmonary inflammation and fibrosis in mice2017
- Author(s)
  Takuma ISSHIKI, Hisaya AKIBA, Masafumi NAKAYAMA, Norihiro HARADA, Ko OKUMURA, Sachiko MIYAKE
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] 抗TIM-3抗体は死細胞貪食を阻害してブレオマイシン肺臓炎を悪化させる2017
- Author(s)
  一色琢磨, 秋葉久弥,中山勝文, 原田紀宏, 奥村康, 三宅幸子, 本間栄
- Organizer
  第21回東京呼吸病態研究会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] TWEAK enhances epithelial mesenchymal transition and chemokine production in human bronchial epithelial cells2017
- Author(s)
  Kei Matsuno, Norihiro Harada, Itoigawa Yukinari, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yuki Tanabe, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] TWEAK and TGF-β induced chemokine production in human bronchial epithelial cells during epithelial mesenchymal transition2017
- Author(s)
  Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Ayako Ishimori, Yuki Tanabe, Hitoshi Sasano, Ai Nakamura, Yoko Katsura, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
- Organizer
  The 22nd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance2016
- Author(s)
  ISSHIKI Takuma, AKIBA Hisaya, NAKAYAMA Masafumi, HARADA Norihiro, OKUMURA Ko, MIYAKE Sachiko
- Organizer
  第45回日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293087
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO 2016 (The Association for Research in Vision and Ophthalmology)
- Place of Presentation
  Seattle, WA, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] TIM-3 regulates pulmonary fibrosis through apoptotic cell clearance2016
- Author(s)
  ISSHIKI Takuma, AKIBA Hisaya, NAKAYAMA Masafumi, HARADA Norihiro, OKUMURA Ko, MIYAKE Sachiko
- Organizer
  第45回日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] Expression of ICOS and Foxp3 on T cells infiltrating in corneal allografts2016
- Author(s)
  H Taniguchi, T Kunishige, H Akiba, H Yagita, R Abe, J Hori
- Organizer
  ARVO
- Place of Presentation
  Seattle, USA
- Year and Date
  2016-05-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462700
[Presentation] OX40L BLOCKADE PROTECTS AGAINST SKIN AND LUNG INFLAMMATION-DRIVEN FIBROSIS2016
- Author(s)
  M. Elhai, J. Avouac, A.-M. Hoffmann-Vold, J. Sadoine, T. Guilbert, H. Akiba, V. Heissmeyer, A. Subramaniam, R. Resnick, G. Chiocchia, Y. Allanore
- Organizer
  欧州リウマチ学会 EULAR 2016
- Place of Presentation
  London, UK
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09924
[Presentation] ICOS promotes group 2 innate lymphoid cell activation in lungs.2015
- Author(s)
  KAMACHI Fumitaka, ISSHIKI Takuma, HARADA Norihiro, AKIBA Hisaya, MIYAKE Sachiko
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25461503
[Presentation] Breast milk conditions intestinal immune system and gut barrier of the infant.2015
- Author(s)
  SAKAGUCHI Keita, KAWASAKI Akemi, KAMACHI Fumitaka, CHIBA Asako, AKIBA Hisaya, SHIMIZU Toshiaki, MIYAKE Sachiko
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25461503
[Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3.2013
- Author(s)
  KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-23390260
[Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-32013
- Author(s)
  KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-25461503
[Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013
- Author(s)
  F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-25461503
[Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013
- Author(s)
  F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23390260
[Presentation] マウス関節炎におけるTIM-4の病態関与:増悪と抑制2012
- Author(s)
  秋葉　久弥
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東　京・グランドプリンスホテル新高輪
- Invited
- Data Source
  KAKENHI-PROJECT-22591098
[Presentation] TIM-1 signaling in B cells regulates antibody production2007
- Author(s)
  Akiba H.
- Organizer
  日本免疫学会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19592040
[Presentation] TIM-1 signaling in B cells regulates antibody production2007
- Author(s)
  Akiba Hisaya
- Organizer
  第37回日本免疫学会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Presentation] TIM-1 signaling in B cells regulates antibody production2007
- Author(s)
  Akiba Hisaya
- Organizer
  第37回日本免疫学会
- Place of Presentation
  グランドプリンスホテル新高輪
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19592040
[Presentation] TIM-1 signaling in B cells regulates antibody production2007
- Author(s)
  Akiba, Hisaya
- Organizer
  The 37th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Grand Prince Hotel New Takanawa
- Year and Date
  2007-11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390292
[Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation.
- Author(s)
  F. Kamachi, N. Harada, J. Ito, K. Takahashi, K. Okumura, S. Miyake, H. Akiba
- Organizer
  The Multifaceted Roles of Type 2 Immunity
- Place of Presentation
  Bruges, Belgium
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25461503
[]

1. NAKANO Hiroyasu (70276476)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. NAKAYAMA Katsufumi (20453582)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. OKUMURA Ko (50009700)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. KAZUYOSHI Takeda (80272821)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. HARADA norihiro (10465065)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
6. ABE yoshiyuki (10647027)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
7. KOJIMA Yuko (60231312)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. YAGITA Hideo (30182306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
9. USUI Yoshihiko (50408142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. USHIO Hiroko (30317391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Hori Junko (60251279)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. Azuma Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Abe Ryo (20159453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 江端智彦 (30343487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 谷口ヒロ子 (00535445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. 國重智之 (60516045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 多田昇弘 (50338315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KAMACHI Fumitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. ISSHIKI Takuma

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. UENO Satoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. CHIBA Asako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. TAKESHIGE tomohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. HARADA sonoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. MATSUNO kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. TAKAMURA Shiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. MORITA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. TAKAHASHI Kayo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 土屋勇一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 服部貴明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 上野宏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 三宅幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 伊藤潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 橋口昌章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 地主将久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 出原賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 辻佐智代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 宮澤正顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 今西健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 高橋尚人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiba Hisaya 秋葉 久弥

秋葉 久弥 アキバ ヒサヤ

AKIBA Hisaya 秋葉 久弥

Research Projects

Research Products

Co-Researchers

Functional analysis of TIM molecules that regulate the pathogenesis of autoimmune and allergic diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Detection of human TIM-4 on autoimmune and allergic diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Immune regulation on autoimmune and allergic diseases by the TIM family molecules

Principal Investigator

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Immune regulation for tissue transplantation and regeneration in the eye

Principal Investigator

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Analysis of therapeutic effect of anti-TIM-4 mAb on inflammatory disease.Principal Investigator

Principal Investigator

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Research Institution

Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

Principal Investigator

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A classification and identification of the asthmatic disease-inducedCD4 T cell subset with costimulatory molecule markerPrincipal Investigator

Principal Investigator

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Research Institution

免疫による癌拒絶局所での分子機構の解析

Principal Investigator

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Review Section

Research Institution

Development of strategy to treat allergic diseases via targeting surface molecules on lymphocytes and intracellular signaling molecules

Principal Investigator

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Research Institution

Development of novel cancer therapy by combination of immune activation with tumor apoptosis induction

Principal Investigator

Project Period (FY)

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Research Institution

Functional analysis of costimulatory molecules in autoimmune uveitis and their intervention for clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Functional analysis of costimulatory molecules for autoimmune diseases

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Identification of Th cells in vivo and analysis of differentiation and function of Th2 cells by costimulatory moleculesPrincipal Investigator

Principal Investigator

Akiba Hisaya 秋葉久弥

秋葉久弥アキバヒサヤ

AKIBA Hisaya 秋葉久弥