IMURA Akihiko 伊村明浩

Researcher Number	60362513
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 京都大学, 医学研究科, 特定病院助教 2014: 公益財団法人先端医療振興財団, 医薬品研究開発部, 研究員 2013 – 2014: 公益財団法人先端医療振興財団, その他部局等, 研究員 2012: 公益財団法人先端医療振興財団, 先端医療センター, 研究員 2011: (財)先端医療振興財団, その他部局等, 研究員 … More 2011: 公益財団法人先端医療振興財団, 先端医療センター, 主任研究員 2011: 公益財団法人先端医療振興財団, 先端医療センター, 主任研究員 2007 – 2010: Kyoto University, 医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator General physiology / Biological Sciences / Kidney internal medicine / Biological Sciences Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Functional biochemistry
Keywords	Principal Investigator グルクロン酸 / クロトー / レクチン / 糖鎖 / FGF23 / 質量分析(MS-MS) / 線維芽細胞増殖因子(FGF) / 電解質(リン・カルシウム) / クロトーレクチンファミリー / PTH … More / Klotho / ノックアウトマウス / テトラスパニン / カルシウム受容体 / 副甲状腺 / ミネラル代謝 / 二次性副甲状腺機能亢進症 / 阻害薬 / 有機合成 / デリバティブ / エストロン / αクロトー / glucronide / シグナル伝達 / 糖鎖認識 / 3-硫酸化グルクロン酸 / 原子間力顕微鏡(AFM) / 糖鎖有機合成 / 表面プラズモン共鳴(SPR) / アルファークロトー / 細胞内シグナル伝達 / 受容体 / ELISA / calcium / klotho / 表面プラズモン共鳴 / Na,K-ATPase / CD13 / ゼタミンD / ビタミンD / 遠位尿細管 / センサー / カルシウム … More Except Principal Investigator NK細胞多型 / 移植片対腫瘍効果 / 移植片対宿主病 / 免疫チェックポイント阻害剤 / KIRシグナル / 次世代シークエンサー / 慢性骨髄性白血病 / 成人T細胞白血病 / NK細胞活性 / 全ゲノムシークエンシング / KIRアレル / 抗腫瘍免疫 / GVHD / KIR / NK細胞受容体 / 同種造血幹細胞移植 / クロトー / ナトリウムカリウム輸送体 / 線維芽細胞増殖因子 / グルクロン酸修飾 / レクチン / 電解質 / 代謝 / 糖鎖 / 蛋白質 / 生理活性 / シグナル伝達 / 細胞・組織 Less

Optimizing immunomodulation of hematopoietic stem cell transplantation focusing on allelic polymorphisms of KIRs
- Principal Investigator
  
  Shindo Takero
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyoto University
Understanding Ca sensing receptor-loaded vesicle in parathyroid glandsPrincipal Investigator
- Principal Investigator
  
  IMURA Akihiro
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Foundation for Biomedical Research and Innovation
αクロトーが認識する糖鎖の構造決定とシグナル様式の解明Principal Investigator
- Principal Investigator
  
  伊村明浩
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Foundation for Biomedical Research and Innovation
Analysis of inhibitory derivatives for parathyroid gland hormone secretionPrincipal Investigator
- Principal Investigator
  
  IMURA AKIHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Foundation for Biomedical Research and Innovation
Identifying the active form of FGF19 based on the fact that beta-Klotho recognizes a distinct sugar motif.
- Principal Investigator
  
  MAEDA Ryota
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  公益財団法人先端医療振興財団
   Foundation for Biomedical Research and Innovation
Analyses of the glycan structure of which Klotho recognizesPrincipal Investigator
- Principal Investigator
  
  IMURA Akihiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  公益財団法人先端医療振興財団
   Kyoto University
クロトー分子と共役するカルシウム代謝分子群のモーダルシフトPrincipal Investigator
- Principal Investigator
  
  伊村明浩
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
遠位尿細管、副甲状腺、脈絡膜に発現する体液カルシウムセンサーの解明Principal Investigator
- Principal Investigator
  
  伊村明浩
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2015 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia2022
- Author(s)
  Ureshino Hiroshi、Kamachi Kazuharu、Shindo Takero、Kimura Shinya
- Journal Title
  
  Indian Journal of Hematology and Blood Transfusion
  
  Volume: - Issue: 4 Pages: 760-761
- DOI
  10.1007/s12288-022-01538-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08812, KAKENHI-PROJECT-20K08756
[Journal Article] Pharmacological MEK inhibition promotes polyclonal T-cell reconstitution and suppresses xenogeneic GVHD2021
- Author(s)
  Itamura Hidekazu、Shindo Takero、Muranushi Hiroyuki、Kitaura Kazutaka、Okada Seiji、Shin-I Tadasu、Suzuki Ryuji、Takaori-Kondo Akifumi、Kimura Shinya
- Journal Title
  
  Cellular Immunology
  
  Volume: 367 Pages: 104410-104410
- DOI
  10.1016/j.cellimm.2021.104410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08812
[Journal Article] HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia2021
- Author(s)
  Ureshino H, Shindo T, Tanaka H, Saji H, Kimura S
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 1 Pages: 142-149
- DOI
  10.1158/1535-7163.mct-20-0336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08756, KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-19K08812
[Journal Article] Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia2020
- Author(s)
  Shindo Takero、Ureshino Hiroshi、Kojima Hiroto、Tanaka Hidenori、Kimura Shinya
- Journal Title
  
  Immunological Medicine
  
  Volume: in press Issue: 2 Pages: 1-8
- DOI
  10.1080/25785826.2020.1796062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-19K08812
[Journal Article] Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation2020
- Author(s)
  Itamura H, Shindo T, Yoshida S, Ishikawa T, Kimura S
- Journal Title
  
  Blood Avvances
  
  Volume: 4 Issue: 4 Pages: 667-671
- DOI
  10.1182/bloodadvances.2019000343
- NAID
  120006878504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09908, KAKENHI-PROJECT-19K08812
[Journal Article] Reconstitution of NK Cells Expressing KIR3DL1 Is Associated With Reduced NK Cell Activity and Relapse of CML After Allogeneic Hematopoietic Stem Cell Transplantation2020
- Author(s)
  Ureshino H, Shindo T, Sano H, Kubota Y, Ando T, Kidoguchi K, Kusaba K, Itamura H, Kojima H, Kusunoki Y, Miyazaki Y, Kojima K, Tanaka H, Saji H, Oshima K, Kimura S
- Journal Title
  
  International Journal of Hematology
  
  Volume: 111 Issue: 5 Pages: 733-738
- DOI
  10.1007/s12185-019-02809-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-19K08812
[Journal Article] Role of cancer immunology in chronic myelogenous leukemia.2020
- Author(s)
  Ureshino H, Shindo T, Kimura S
- Journal Title
  
  Leuk Res
  
  Volume: 88 Pages: 196273-196273
- DOI
  10.1016/j.leukres.2019.106273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08812, KAKENHI-PROJECT-19K17860
[Journal Article] Clinical impact of the CONUT score in patients with multiple myeloma2020
- Author(s)
  Okamoto S, Ureshino H*, Kidoguchi K, Kusaba K, Kizuka-Sano H, Sano H, Nishioka A, Yamaguchi K, Kamachi K, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Kawaguchi A, Sueoka E, Kimura S.
- Journal Title
  
  Ann Hematol
  
  Volume: 99 Issue: 1 Pages: 113-119
- DOI
  10.1007/s00277-019-03844-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-19K17860, KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-19K08812
[Journal Article] Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma.2019
- Author(s)
  Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Sueoka E, Kimura S.
- Journal Title
  
  Annals of Hematology
  
  Volume: 98 Issue: 2 Pages: 465-471
- DOI
  10.1007/s00277-018-3502-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09851, KAKENHI-PROJECT-17K09928, KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-19K08812
[Journal Article] Epstein-Barr virus-related diffuse large B cell lymphoma in mogamulizumab-treated adult T cell leukemia with incomplete T cell reconstitution.2019
- Author(s)
  Kamachi K, Shindo T*, Miyahara M, Kitaura K, Akashi M, Shin-I T, Suzuki R, Ohshima K, Kimura S
- Journal Title
  
  Int J Hematol
  
  Volume: 109 Issue: 2 Pages: 221-227
- DOI
  10.1007/s12185-018-2552-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08812
[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014
- Author(s)
  Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
- Journal Title
  
  PLoS One.
  
  Volume: 9(1):e86301 Issue: 1 Pages: 1-1
- DOI
  10.1371/journal.pone.0086301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23659444, KAKENHI-PROJECT-24591355, KAKENHI-PROJECT-24659415, KAKENHI-PROJECT-25293187, KAKENHI-PROJECT-25461226
[Journal Article] Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.2014
- Author(s)
  Nabeshima Y., Washida M., Tamura M., Maeno A., Ohnishi M., Shiroishi T., Imura A., Razzaque MS., Nabeshima Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 1-7
- DOI
  10.1038/srep05847
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22229003, KAKENHI-PROJECT-24247002, KAKENHI-PLANNED-26115004, KAKENHI-PROJECT-26670108
[Journal Article] Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo2013
- Author(s)
  Imura Akihiro
- Journal Title
  
  Clinical Calcium
  
  Volume: 10 Pages: 1476-82
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Updates on rickets and osteomalacia : various roles of Klotho and FGF23 in vivo2013
- Author(s)
  Imura A
- Journal Title
  
  Clin Calcium (Review. Japanese)
  
  Volume: 23(10)(doi:CliCa131014761482.) Pages: 1476-82
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Complex regulation and diverse functions of alpha-klotho.2013
- Author(s)
  Maeda Ryota, Imura Akihiro, Nabeshima Yo-ichi
- Journal Title
  
  Contrib Nephrol
  
  Volume: 180 Pages: 25-46
- DOI
  10.1159/000346777
- ISBN
  9783318023695, 9783318023701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659444, KAKENHI-PROJECT-23770166, KAKENHI-PUBLICLY-25121747
[Journal Article] Serum soluble α-klotho in hemodialysis patients.2012
- Author(s)
  Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino H, Nabeshima Y, Hosoya T.
- Journal Title
  
  Clin Nephrol.
  
  Volume: 77 Pages: 347-351
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117518
[Journal Article] Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.2012
- Author(s)
  Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, Imura A, Nabeshima Y, Chrousos G.
- Journal Title
  
  Eur J Endocrinol.
  
  Volume: 167 Issue: 3 Pages: 433-40
- DOI
  10.1530/eje-12-0476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659444, KAKENHI-PUBLICLY-23117518
[Journal Article] Serum solubleα-klotho in hemodialysis patlents2012
- Author(s)
  Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino H, Nabeshima Y, Hosoya T
- Journal Title
  
  Clin Nephrol
  
  Volume: 77(5) Pages: 347-51
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Serum soluble alpha-Klotho in hemodialysis patients2012
- Author(s)
  Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino H, Nabeshima YI, Hosoya T
- Journal Title
  
  Clin Nephrol
  
  Volume: 77(5) Pages: 347-51
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] alpha-Klothoの構造と機能2012
- Author(s)
  伊村明浩
- Journal Title
  
  腎と骨代謝
  
  Volume: vol.25 Pages: 33-40
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Decreased renalα-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
- Author(s)
  Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
- Journal Title
  
  Kidney Int
  
  Volume: 81(6) Pages: 539-47
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Plasma soluble α-klotho protein levels in premature and term neonates : correlations with growth and metabolic parameters2012
- Author(s)
  Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, Imura A, Nabeshima Y, Chrousos G
- Journal Title
  
  Eur J Endocrinol
  
  Volume: 167(3) Pages: 433-40
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
- Author(s)
  Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
- Journal Title
  
  Kidney Int
  
  Volume: 81 Pages: 539-547
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117518
[Journal Article] Serum soluble α-klotho in hemodialysis patients.2012
- Author(s)
  Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, Urae J, Sekino H, Nabeshima Y, Hosoya T.
- Journal Title
  
  Clin Nephrol.
  
  Volume: 77 Pages: 347-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary Calcium excretion2012
- Author(s)
  Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
- Journal Title
  
  Kidney Int
  
  Volume: 81(6) Pages: 539-47
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.2012
- Author(s)
  Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y.
- Journal Title
  
  Kidney Int
  
  Volume: 81 Pages: 539-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Klotho, メタボリックFGFによる代謝の統合制御2012
- Author(s)
  Nabeshima Y-I, Imura A, Maeda R
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 252-259
- Data Source
  KAKENHI-PROJECT-23770166
[Journal Article] circulating levels of soluble a-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K.
- Journal Title
  
  J clin Endocrinol Metab
  
  Volume: 96 Pages: 943-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Klothoファミリーによる内分泌性FGFのシグナル制御2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Journal Title
  
  細胞工学
  
  Volume: 31巻 Pages: 434-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770166
[Journal Article] circulating levels of soluble a-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
- Journal Title
  
  J clin Endocrinol Metab
  
  Volume: 96 Pages: 943-947
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117518
[Journal Article] Circulating levels of soluble a-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
- Journal Title
  
  J clin Endocrinol Metab
  
  Volume: 96 Pages: 943-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] ファミリーによる内分泌性FGFのシグナル制御2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一、Klotho
- Journal Title
  
  細胞工学
  
  Volume: 31巻 Pages: 434-439
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] メタボリックFGFによる代謝の統合制御2011
- Author(s)
  鍋島陽一、伊村明浩、前田良太
- Journal Title
  
  実験医学
  
  Volume: 30巻 Pages: 252-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770166
[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2011
- Author(s)
  Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
- Journal Title
  
  Kidney Int
  
  Volume: 81 Pages: 539-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] メタボリックFGFによる代謝の統合制御2011
- Author(s)
  鍋島陽一、伊村明浩、前田良太、Klotho
- Journal Title
  
  実験医学
  
  Volume: 30巻 Pages: 252-259
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
- Journal Title
  
  J CIin Endocrinol Metab
  
  Volume: 96(6)
- Data Source
  KAKENHI-PROJECT-23659444
[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
- Author(s)
  Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 96(6)
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Establishment of sandwich ELISA for soluble alpha-Klotho measurement : Age-dependent change of soluble alpha-Klotho levels in healthy subjects2010
- Author(s)
  Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 398(3) Pages: 513-8
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Relevant use of Klotho in FGF19 subfamily signaling system in vivo2010
- Author(s)
  Tomiyama K, Maeda R, Urakawa I, Yamazaki Y, Tanaka T, Ito S, Nabeshima Y, Tomita T, Odori S, Hosoda K, Nakao K, Imura A, Nabeshima Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 107(4) Pages: 1666-71
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Persistent alpha-Klotho(a-Kl) expression in the parathyroid glands of patients with secondary hyperparathyroidism2010
- Author(s)
  Ohkido I, Yokoyama K, Imura A, Utsunomiya Y, Hosoya T, Nabeshima Y
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 25(3) Pages: 1007-8
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] αクロトー研究から見たエイジング2009
- Author(s)
  伊村明浩、鍋島陽一
- Journal Title
  
  日本臨床
  
  Volume: 67 Pages: 1283-1288
- Data Source
  KAKENHI-PROJECT-21390058
[Journal Article] Aspects of mammalian aging from alphaklotho study2009
- Author(s)
  Imura A, Nabeshima Y.
- Journal Title
  
  Nippon Rinsho. 2009 Jut ; 67(7) 67
  
  Pages: 1283-1288
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21026017
[Journal Article] A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism2008
- Author(s)
  Brownstein CA, Adler F,Nelson-Williams C, Iijima J, Li P, Imura A, Nabeshima Y, Reyes-MUgica M, Carpenter TO, Lifton RP.
- Journal Title
  
  Proc Natl Acad Sci USA. 105
  
  Pages: 455-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045016
[Journal Article] a-Klotho: A regulator that integrates calcium homeostasis2008
- Author(s)
  Nabeshima YI and Imura A
- Journal Title
  
  American journal of nephrology 28
  
  Pages: 455-464
- Data Source
  KAKENHI-PROJECT-19045016
[Journal Article] alpha-Klotho : a regulator that integrates calcium homeostasis2008
- Author(s)
  Nabeshima Y, Imura A.
- Journal Title
  
  Am J Nephrol. 28
  
  Pages: 3455-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045016
[Journal Article] a-KlothoとPTH分泌調節制御2008
- Author(s)
  伊村明浩
- Journal Title
  
  内分泌糖尿病科 26
  
  Pages: 536-47
- Data Source
  KAKENHI-PROJECT-19045016
[Journal Article] alpha-Klotho as a regulator of calcium homeostasis2007
- Author(s)
  Imura a, et. al.
- Journal Title
  
  Science 316
  
  Pages: 1615-1618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19045016
[Journal Article] カルシウム代謝とa-Klotho2007
- Author(s)
  伊村明浩
- Journal Title
  
  The Bone 21
  
  Pages: 79-83
- Data Source
  KAKENHI-PROJECT-19045016
[Patent] α-Klotho/FGF23複合体形成阻害化合物2013
- Inventor(s)
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Rights Holder
  前田良太、伊村明浩、鍋島陽一
- Acquisition Date
  2013-02-07
- Data Source
  KAKENHI-PROJECT-23659444
[Patent] α-Klotho/FGF23複合体形成阻害化合物2011
- Inventor(s)
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Rights Holder
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Number
  2011-136719
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23770166
[Patent] α-Klotho. FGF23複合体形成阻害化合2011
- Inventor(s)
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Rights Holder
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Number
  2011-136719
- Filing Date
  2011-06-19
- Data Source
  KAKENHI-PROJECT-21390058
[Patent] Alpha-Klotho/FGF23複合体形成阻害化合物2011
- Inventor(s)
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Rights Holder
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Number
  2011-136719
- Filing Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-23770166
[Patent] α-Klotho/FGF23複合体形成阻害化合物2011
- Inventor(s)
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Rights Holder
  前田良太、伊村明浩、鍋島陽一
- Industrial Property Number
  2011-136719
- Filing Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] HLA polymorphisms is associated with treatment-free remission following TKI discontinuation.2020
- Author(s)
  Ureshino H, Shindo T, Kimura S.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08812
[Presentation] Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML2019
- Author(s)
  Takero Shindo, Hiroshi Ureshino, Shinya Kimura
- Organizer
  The 78th Annual Meeting of the Japanese Cancer Association
- Invited
- Data Source
  KAKENHI-PROJECT-19K08812
[Presentation] The MEK Inhibitor Trametinib Enhances Diverse T Cell Reconstitution with Suppressing Xenogeneic Graft-Versus-Host-Disease2019
- Author(s)
  Hidekazu Itamura, Hiroyuki Muranushi, Takero Shindo, Kazutaka Kitaura, Seiji Okada, Tadasu Shin-I, Ryuji Suzuki, Akifumi Takaori-Kondo, Shinya Kimura
- Organizer
  The 62nd Annual Meeting of the American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08812
[Presentation] MEK inhibitor trametinib enhances diverse T cell reconstitution with suppressing xenogeneic GVHD2019
- Author(s)
  Hiroyuki Muranushi, Hidekazu Itamura, Takero Shindo, Kazutaka Kitaura, Seiji Okada, Tadasu Shin-I, Ryuji Suzuki, Akifumi Takaori-Kondo, Shinya Kimura
- Organizer
  The 81st Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-19K08812
[Presentation] Phenotype of CD13 and tetraspanin KO mice2015
- Author(s)
  Akihiro Imura
- Organizer
  Glycomics meeting, Copenhagen center for Glycomics
- Place of Presentation
  Copenhagen university
- Year and Date
  2015-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670108
[Presentation] クロトーが結合モチーフとして認識する糖鎖構造2013
- Author(s)
  伊村明浩
- Organizer
  第６７回日本栄養・食料学会大会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] 生理機能に特化したGPCR搭載小胞の発見と機能解析2013
- Author(s)
  伊村明浩
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] αKlotho enables the distinct interactions by recognition of a specific sugar motif to mediate mineral homeostasis.2013
- Author(s)
  Imura Akihiro
- Organizer
  国際骨代謝学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] aKlotho as a glucuronide lectin and further studies of calcium sensing2013
- Author(s)
  Imura Akihiro
- Organizer
  マサチューセッツ総合病院内分泌内科セミナー
- Place of Presentation
  マサチューセッツ総合病院
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] αKlotho enables the distinct interactions by recognition of a specific sugar motif to mediate mineral homeostasis.2013
- Author(s)
  Imura Akihiro
- Organizer
  日本骨代謝学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] Caイオンの恒常性：クロトー問題からの新展開2012
- Author(s)
  伊村明浩
- Organizer
  抗老化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] クロトーが認識する糖鎖の構造決定とシグナル様式の解明2012
- Author(s)
  伊村明浩
- Organizer
  新学術領域　シグナル修飾病　領域会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] クロトーが結合モチーフとして認識する糖鎖構造2012
- Author(s)
  伊村明浩
- Organizer
  細胞センサーの分子機構・相互連関・ネットワーク研究会
- Place of Presentation
  岡崎
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] クロトーの奇妙な構造2012
- Author(s)
  伊村明浩
- Organizer
  筑波大学医学研究科TSMMセミナー
- Place of Presentation
  つくば市
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117518
[Presentation] アルファクロトーの役割：糖鎖認識が可能にする多面性2012
- Author(s)
  伊村明浩
- Organizer
  The Fifteenth Lilly International Symposium
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117518
[Presentation] クロトーは修飾糖鎖を認識することでFGFシグナルを伝える2012
- Author(s)
  前田良太、伊村明浩
- Organizer
  第二回公開シンポジウム「修飾シグナル病」学術領域の新展開、ポスター発表
- Place of Presentation
  東京
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] クロトーは修飾糖鎖を認識することでFGFシグナルを伝える2012
- Author(s)
  前田良太、伊村明浩
- Organizer
  第二回公開シンポジウム「修飾シグナル病」学術領域の新展開、ポスター発表
- Place of Presentation
  東
- Year and Date
  2012-01-28
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] アルファクロトーの役割：糖鎖認識が可能にする多面性2012
- Author(s)
  伊村明浩
- Organizer
  第1回生理研研究会「細胞センサーの分子機構・相互連関・ネットワーク研究会」
- Place of Presentation
  愛知県岡崎市
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PUBLICLY-23117518
[Presentation] Caイオンの恒常性：クロトー問題からの新展開2012
- Author(s)
  伊村明浩
- Organizer
  抗老化学会
- Place of Presentation
  横浜市
- Year and Date
  2012-06-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-23117518
[Presentation] アルファクロトーの役割：糖鎖認識が可能にする多面性2012
- Author(s)
  伊村明浩
- Organizer
  The Fifteenth Lilly International Symposium
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] クロトーの奇妙な構造2012
- Author(s)
  伊村明浩
- Organizer
  筑波大学医学研究科TSMMセミナー
- Place of Presentation
  つくば
- Invited
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] Different profiles of acute PTH secretion : A comparison between alpha-Klotho and FGF23-knockout mice2011
- Author(s)
  Imura Akihiro、Nabeshima Yo-ichi
- Organizer
  The endocrine society's 93^<rd> annual meeting and EXPO
- Place of Presentation
  Boston、USA
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会、ポスター発表
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] Different profiles of acute PTH secretion2011
- Author(s)
  Imura A, Nabeshima Y
- Organizer
  Endo2011
- Place of Presentation
  Boston
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] A glucuronized steroid is useful for cure of FGF23-and alpha-Klotho dependent rickets2011
- Author(s)
  Maeda Ryota、Imura Akihiro、Nabeshima Yo-ichi
- Organizer
  The endocrine society's 93^<rd> annual meeting and EXPO
- Place of Presentation
  Boston、USA
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] ProteOn XRPシステムを用いたクロトーレクチンの糖タンパク質、糖鎖、糖脂質との結合解析への応用2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会バイオインダストリーセミナー、招待講演
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] ProteOn XRPシステムを用いたクロトーレクチンの糖タンパク質、糖鎖、糖脂質との結合解析への応用2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第８４回日本生化学会大会　バイオインダストリーセミナー(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] αクロトーが認識する糖鎖の構造決定とシグナル様式の解明2011
- Author(s)
  伊村明浩
- Organizer
  平成23年新学術領域「シグナル修飾病」第1回領域推進会議
- Place of Presentation
  東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] ProteOnXRPシステムを用いたクロトーレクチンの糖タンパク質、糖鎖、糖脂質との結合解析への応用2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会バイオインダストリーセミナー
- Place of Presentation
  京都、招待講演
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会、ポスター発表
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会、口演発表
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第８４回日本生化学会大会　口演発表
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] Klotho acts as a novel lectin that binds terminal sulfated glucuronyl moieties2011
- Author(s)
  Maeda Ryota、Imura Akihiro、Nagata Kazuhiro、Henrissat Bernard、Nabeshima Yo-ichi
- Organizer
  The 31^<st> Naito Conference
- Place of Presentation
  Sapporo
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  前田良太、伊村明浩、鍋島陽一
- Organizer
  第84回日本生化学会大会、口演発表
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] Different profiles of acute PTH secretion2011
- Author(s)
  Imura A, Nabeshima Y
- Organizer
  Endo2011
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] A glucuronized steroid is usefur for cure of FGF23- and alpha-Klotho dependent rickets.2011
- Author(s)
  Maeda R, Imura A, Nabeshima Y-I.
- Organizer
  The endocrine society’s 93rd annual meeting and EXPO
- Place of Presentation
  ボストン：米国
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] 糖鎖認識が可能にするクロトー分子の多機能性2011
- Author(s)
  Imura A
- Organizer
  新学術領域「シグナル修飾病」領域会議
- Place of Presentation
  東京大学医科学研究所
- Data Source
  KAKENHI-PROJECT-23659444
[Presentation] Different profiles of acute PTH secretion2011
- Author(s)
  Imura A, Nabeshima Y
- Organizer
  Endo2011
- Place of Presentation
  Boston
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PUBLICLY-23117518
[Presentation] グルクロン酸認識レクチンとしてのクロトー2011
- Author(s)
  Maeda R, Imura A, Nabeshima Y-I.
- Organizer
  第８４回日本生化学会大会　ポスター発表
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] Klotho acts as a novel lectin that binds terminal sulfated glucuronyl moieties.2011
- Author(s)
  Maeda R, Imura A, Nagata K, Henrissat B, Nabeshima Y-I.
- Organizer
  The 31st Naito Conference
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23770166
[Presentation] クロトー分子と共役するカルシウム代謝分子群のモーダルシフト2010
- Author(s)
  伊村明浩
- Organizer
  セルセンサー平成22年度冬の班会議
- Place of Presentation
  国際交流会館
- Year and Date
  2010-12-24
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] クロトー分子と共役するカルシウム代謝分子群のモーダルシフト2010
- Author(s)
  伊村明浩
- Organizer
  平成22年度特定領域研究「セルセンサー」冬の班会議
- Place of Presentation
  国際交流会館
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] クロトー分子と共役するカルシウム代謝分子群のモーダルシフト2010
- Author(s)
  伊村明浩
- Organizer
  セルセンサー平成22年度冬の班会議
- Place of Presentation
  国際交流会館
- Year and Date
  2010-12-24
- Data Source
  KAKENHI-PUBLICLY-21026017
[Presentation] 遠位尿細管、副甲状腺、脈絡膜に発現する体液カルシウムセンサーの解明2009
- Author(s)
  伊村明浩
- Organizer
  平成21年度特定領域研究「セルセンサー」夏の班会議
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] クロトー分子と共役するカルシウム代謝分子群のモーダルシフト2009
- Author(s)
  伊村明浩
- Organizer
  セルセンサー平成21年度冬の班会議
- Place of Presentation
  箕面観光ホテル
- Year and Date
  2009-12-24
- Data Source
  KAKENHI-PROJECT-21390058
[Presentation] alpha-Klothoが統御するカルシウム恒常性2007
- Author(s)
  伊村明浩
- Organizer
  日本分子生物学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19045016

1. MAEDA Ryota (50432399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. Shindo Takero (10646706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 高折晃史 (20324626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 木村晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 久保田寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 嬉野博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 鍋島洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小島研介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMURA Akihiko 伊村 明浩

Research Projects

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Co-Researchers

Optimizing immunomodulation of hematopoietic stem cell transplantation focusing on allelic polymorphisms of KIRs

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Understanding Ca sensing receptor-loaded vesicle in parathyroid glandsPrincipal Investigator

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αクロトーが認識する糖鎖の構造決定とシグナル様式の解明Principal Investigator

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Analysis of inhibitory derivatives for parathyroid gland hormone secretionPrincipal Investigator

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Identifying the active form of FGF19 based on the fact that beta-Klotho recognizes a distinct sugar motif.

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Analyses of the glycan structure of which Klotho recognizesPrincipal Investigator

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クロトー分子と共役するカルシウム代謝分子群のモーダルシフトPrincipal Investigator

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遠位尿細管、副甲状腺、脈絡膜に発現する体液カルシウムセンサーの解明Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia2022

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[Journal Article] Pharmacological MEK inhibition promotes polyclonal T-cell reconstitution and suppresses xenogeneic GVHD2021

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[Journal Article] HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia2021

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[Journal Article] Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia2020

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[Journal Article] Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation2020

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[Journal Article] Reconstitution of NK Cells Expressing KIR3DL1 Is Associated With Reduced NK Cell Activity and Relapse of CML After Allogeneic Hematopoietic Stem Cell Transplantation2020

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IMURA Akihiko 伊村明浩