Ookubo Akihiro 大窪章寛

… Alternative Names

Ohkubo Akihiro 大窪章寛

OHKUBO Akihiro 大窪章寛

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Researcher Number	60376960
Other IDs
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京工業大学, 生命理工学院, 准教授 2016 – 2018: 東京工業大学, 生命理工学院, 准教授 2012 – 2014: 東京工業大学, 生命理工学研究科, 准教授 2007 – 2011: Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 2006: 東京工業大学, 大学院・生命理工学研究科, 助手
Review Section/Research Field	Principal Investigator Chemistry related to living body / Basic Section 37010:Bio-related chemistry / Bio-related chemistry Except Principal Investigator Living organism molecular science
Keywords	Principal Investigator 核酸合成 / 核酸 / 核酸医薬 / 固相合成 / 高分子化学 / 有機化学 / RNAアプタマー / U11 snRNA / U1 snRNA / スプライシング … More / U snRNA / ゲノムDNA / DNA / ポーラスガラス / ホスホロアミダイト / DNA合成 / アミノ酸 / ホスホロアミダイト法 / アミノアシルtRNA / RNA合成 / tRNA / 保護基 / アミノシルtRNA / ゲノム … More Except Principal Investigator グアノシン / アデノシン / 合成モノマーユニット / 脱アミノ化反応 / シアノエチル化 / 2'-保護基 / マイケル反応 / RNAの化学合成 / 塩基部無保護 / 2'水酸某の保護基 / 固相合成法 / MCE基 / アミダイトユニット / シアノエチル基 / Michael反応 / RNA医薬 / 2'水酸基の保護基 / 筋ジストロフィー / RNA合成 / 生体高分子 Less

RNAアプタマーアレイを用いた修飾RNAの分子進化Principal Investigator
- Principal Investigator
  
  大窪章寛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Institute of Science Tokyo
Development of modified U1 snRNA derivatives as new nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  Ohkubo Akihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo Institute of Technology
Development of a new method for chemical synthesis of genomic DNAsPrincipal Investigator
- Principal Investigator
  
  AKIHIRO Ohkubo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo Institute of Technology
Development of artificial aminoacylated tRNA with high efficiency of turnoverPrincipal Investigator
- Principal Investigator
  
  OHKUBO Akihiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo Institute of Technology
Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New day
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tokyo Institute of Technology
Development of a new method for chemical synthesis of aminoacylated tRNA.Principal Investigator
- Principal Investigator
  
  OHKUBO Akihiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo Institute of Technology
ゲノムDNAの精密有機化学合成Principal Investigator
- Principal Investigator
  
  大窪章寛
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo Institute of Technology

All 2023 2018 2017 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] 新しいDNAチップの科学と応用2007
- Author(s)
  大窪章寛(関根光雄編)
- Total Pages
  239
- Publisher
  講談社サイェンティフィク
- Data Source
  KAKENHI-PROJECT-18750144
[Book] "ファイバー"スーパーバイオミメティックス(本宮達也監)2006
- Author(s)
  関根光雄, 大窪章寛, 岡本到, 清尾康志
- Total Pages
  1236
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine2018
- Author(s)
  akeshi Inde, Shuhei Nishizawa, Yuusaku Hattori, Takashi Kanamori, Hideya Yuasa, Kohji Seio, Mitsuo Sekine, Akihiro Ohkubo
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 26 Issue: 13 Pages: 3785-3790
- DOI
  10.1016/j.bmc.2018.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19194, KAKENHI-PROJECT-16H04176, KAKENHI-PROJECT-17H04886, KAKENHI-PROJECT-16K05840
[Journal Article] pH-Dependent Switching of Base Pairs Using Artificial Nucleobases with Carboxyl Groups2018
- Author(s)
  Kaewsomboon T, Nishizawa S, Kanamori T, Yuasa H, Ohkubo A
- Journal Title
  
  The Journal of Organic CHemistry
  
  Volume: 83 Issue: 3 Pages: 1320-1320
- DOI
  10.1021/acs.joc.7b02828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05840, KAKENHI-PROJECT-17K19194, KAKENHI-PROJECT-16H04176
[Journal Article] Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect2017
- Author(s)
  Takashi Kanamori, Takashi Sawamura, Tatsumi Tanaka, Izumi Sotokawa, Ryota Mori, Kotaro Inada, Akihiro Ohkubo, Shun-Ichiro Ogura, Yasutoshi Murayama, Eigo Otsuji, Hideya Yuasa
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Issue: 2 Pages: 743-749
- DOI
  10.1016/j.bmc.2016.11.050
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04176, KAKENHI-PROJECT-26430141, KAKENHI-PROJECT-16K05840
[Journal Article] Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation2017
- Author(s)
  Kanamori T, Takamura A, Tago N, Masaki Y, Ohkubo A, Sekine M, Seio K.
- Journal Title
  
  Organic and Biomolecular Chemistry
  
  Volume: 15 Issue: 5 Pages: 1190-1197
- DOI
  10.1039/c6ob01278g
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26288075, KAKENHI-PROJECT-16K05840
[Journal Article] Enzymatic synthesis and reverse transcription of RNAs incorporating 2 -O-carbamoyl uridine triphosphate2016
- Author(s)
  Masaki Y, Ito H, Oda Y, Yamazaki K, Tago N, Ohno K, Ishii N, Tsunoda H, Kanamori T, Ohkubo A, Sekine M, Seio K.
- Journal Title
  
  Chemical Communications
  
  Volume: 52 Issue: 87 Pages: 12889-12892
- DOI
  10.1039/c6cc05796a
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01062, KAKENHI-PROJECT-26288075, KAKENHI-PROJECT-15K13738, KAKENHI-PROJECT-26810086, KAKENHI-PROJECT-16K05840
[Journal Article] Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component.2014
- Author(s)
  Masaki Y, Miyasaka R, Hirai K, Kanamori T, Tsunoda H, Ohkubo A, Seio K, Sekine M
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 7 Pages: 1157-1162
- DOI
  10.1039/c3ob41983e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Properties of 5- and/or 2-modified 2'-O-cyanoethyl uridine residue: 2'-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component.2014
- Author(s)
  Yamada K, Masaki Y, Tsunoda H, Ohkubo A, Seio K, Sekine M.
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 14 Pages: 1157-62
- DOI
  10.1039/c3ob42420k
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] Synthesis and properties of oligonucleotides modified with 2'-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives.2014
- Author(s)
  Yamada T, Masaki Y, Okaniwa N, Kanamori T, Ohkubo A, Tsunoda H, Seio K, Sekine M
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 12 Issue: 33 Pages: 6457-6464
- DOI
  10.1039/c4ob01260g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074, KAKENHI-PROJECT-26810086
[Journal Article] Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region. Bioorg2013
- Author(s)
  Seio, K.; Tokugawa, M.; Tsunoda, H.; Ohkubo, A.; Arisaka, F.; Sekine, M
- Journal Title
  
  Med. Chem. Lett
  
  Volume: 23 Issue: 24 Pages: 6822-6824
- DOI
  10.1016/j.bmcl.2013.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350077, KAKENHI-PROJECT-23570190, KAKENHI-PROJECT-24550184
[Journal Article] Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine2013
- Author(s)
  Seio, K.; Kanamori, T.; Tokugawa, M.; Ohzeki, H.; Masaki, Y.; Tsunoda, H.; Ohkubo, A.; Sekine, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 23 Issue: 11 Pages: 3197-3201
- DOI
  10.1016/j.bmc.2013.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350077, KAKENHI-PROJECT-24550184
[Journal Article] Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups.2013
- Author(s)
  Yamada K, Hattori Y, Inde T, Kanamori T, Ohkubo A, Seio K, Sekine M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 3 Pages: 776-8
- DOI
  10.1016/j.bmcl.2012.11.079
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Chemical Synthesis of UlsnRNA Derivatives2013
- Author(s)
  Ohkubo, A.; Kondo, Y.; Suzuki, M.;Kobayashi, H.;Kanamori, T.; Masaki, Y.; Seio, K.; Nagai, K.; Sekine, M
- Journal Title
  
  Org. Lett
  
  Volume: 15 Issue: 17 Pages: 4386-4389
- DOI
  10.1021/ol401917r
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides.2013
- Author(s)
  Yamada K, Ohkubo A, Esaka Y, Kanamori T, Masaki Y, Seio K, Sekine M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 11 Pages: 3448-51
- DOI
  10.1016/j.bmcl.2013.03.054
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184, KAKENHI-PROJECT-25288074
[Journal Article] Modified oligodeoxynucleotide primers for reversetranscription of target RNAs that can discriminate among length variants at the 3'-terminus2013
- Author(s)
  Iijima, Y.; Kojima, S.; Kodama, E.; Kurohagi, S.; Kanamori, T.; Masaki, Y.; Ohkubo, A.; Sekine, M.; Seio, K.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 11 Issue: 47 Pages: 8276-8282
- DOI
  10.1039/c3ob41901k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350077, KAKENHI-PROJECT-24550184
[Journal Article] Prediction of the stability of modified RNA duplexes based on deformability analysis: 0ligoribonucleotide derivatives modified with 2'O-cyanoethyl- 5-propynyl-2-thiouridine as a promising component2012
- Author(s)
  Masaki, Y.; Miyasaka, R.;Hirai, K.;Tsunoda, H.; Ohkubo, A.;Seio, K.;Sekine, M
- Journal Title
  
  Chem. Commun
  
  Volume: 48 Issue: 58 Pages: 7313-7315
- DOI
  10.1039/c2cc33409g
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts.2012
- Author(s)
  T. Harakawa, H. Tsunoda, A. Ohkubo, K. Seio, and M. Sekine,
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 3 Pages: 1445-1447
- DOI
  10.1016/j.bmcl.2011.12.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550184
[Journal Article] Synthesis of 5'-Terminal Capped Oligonucleotides Using O-N Phosphoryl Migration of Phosphoramidite Derivatives2012
- Author(s)
  Ohkubo, A.;Tago, N.;Nishino, Y.;Yamada, K.; Tsunoda, H.:Seio, K.:Sekine, M
- Journal Title
  
  Org. Lett
  
  Volume: 14 Issue: 1 Pages: 10-13
- DOI
  10.1021/ol2026075
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-24550184
[Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming Stable and Selective Triplexes2012
- Author(s)
  T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, and K. Seio
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10巻 Pages: 1007-1013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Cationic 2'-O-[ N-(4-aminobutyl) carbamoyl] modified Oligonucleotides.2012
- Author(s)
  K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22巻 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] DNA Duplexes and Triplex-Forming Oligodeoxynucleotides Incorporating Modified Nucleosides Forming stable and Selective Triplexes2012
- Author(s)
  Kanamori, T.; Masaki, Y.; Mizuta, M.; Tsunoda, H.; Ohkubo, A.; Sekine, M.; Seio, K.
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 10 Issue: 5 Pages: 1007-1013
- DOI
  10.1039/c1ob06411h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053
[Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012
- Author(s)
  Ohkubo, A.; Nishino, Y.; Ito, Y.; Tsunoda, H.; Seio, K.; Sekine
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 10 Issue: 10 Pages: 2008-2010
- DOI
  10.1039/c2ob06641f
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21106007, KAKENHI-PROJECT-21241053, KAKENHI-PROJECT-22750146, KAKENHI-PROJECT-24550184
[Journal Article] Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents2012
- Author(s)
  K. Seio, S. Kurohagi, E. Kodama, H. Tsunoda, A. Ohkubo and M. Sekine
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 994-1006
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Formation of New Base Pairs between Inosine and 5-Methyl-2-thiocytidine Derivatives2012
- Author(s)
  A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, and M. Sekine
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10巻 Pages: 10-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes2012
- Author(s)
  T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, K. Seio
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 1007-1013
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives2012
- Author(s)
  A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, and M. Sekine
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 2008-2010
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesi and Properties of Cationic 2'-O-[N-(4-aminobutyl)carbamoyl]modified Oligonucleotides2012
- Author(s)
  Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 2470-2473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and properties of cationic 2' -O-[N-(4-aminobutyl)carbamoyl]modified oligonucleotides2012
- Author(s)
  Seio, K.; Tokugawa, M.; Kanamori, T.; Tsunoda, H.; Ohkubo, A.; Sekine, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22 Issue: 7 Pages: 2470-2473
- DOI
  10.1016/j.bmcl.2012.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350077, KAKENHI-PROJECT-24550184, KAKENHI-PLANNED-21106007
[Journal Article] Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts.2012
- Author(s)
  T. Harakawa, H. Tsunoda, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22 Pages: 1445-1447
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis of 5'-Terminal Capped Oligonucleotide using O. N Phosphoryl Migration of Phosphoramidite Derivatives2012
- Author(s)
  A. Ohkubo, N. Tago, A. Yokouchi, Y. Nishino, K. Yamada, H. Tsunoda, K. Seio, M. Sekine
- Journal Title
  
  Org. Lett.
  
  Volume: 14 Pages: 10-13
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis of 5'-Terminal Capped Oligonucleotide using O-N Phosphoryi Migration of Phosphoramidite Derivatives2012
- Author(s)
  A.Ohkubo, N.Tago, A.Yokouchi, Y.Nishino, K.Yamada, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Org.Lett.
  
  Volume: 14 Pages: 10-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis of 2'-O-[ 2-(N-Methylcarbamoyl) ethyl] ribonucl eosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides2011
- Author(s)
  T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, and M. Sekine
- Journal Title
  
  J. Org. Chem
  
  Volume: 76巻 Pages: 3042-3053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and hybridization properties of 2'-O-methylated oligoribonucleotides incorporating 2'-O-naphthyluridines2011
- Author(s)
  M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 9 Pages: 210-218
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine2011
- Author(s)
  S. Cao, I. Okamoto, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 52 Pages: 407-410
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis and Hybridization Properties of 2'-O-Methylated Oligoribonucleotides Incorporating 2'-O-Naphthyluridines2011
- Author(s)
  M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, and K. Seio
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 9巻 Pages: 210-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Stable triplx formation using the strong stacking effect of consecutive thionucleoside moieties2011
- Author(s)
  A.Ohkubo, Y.Nishino, A.Yokouchi, Y.Ito, Y.Noma, Y.Kakishima, Y.Masaki, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Chem.Comm.
  
  Volume: 47 Issue: 46 Pages: 12556-12558
- DOI
  10.1039/c1cc14339e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions2011
- Author(s)
  H. Tsunoda, T. Kudo, Y. Masaki, A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 39 Pages: 2995-3004
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis of 2'-O-[ 2-(N-Methylcarbamoyl) ethyl] ribon ucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides2011
- Author(s)
  Y. Takeshi, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, M. Sekine
- Journal Title
  
  J. Org. Chem
  
  Volume: 76 Pages: 3042-3053
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis of 6-N-(Benzothiazol-2-yl) deoxyadenosine and Its Exciton-coupled Circular Dichroism2010
- Author(s)
  Y. Masaki, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18巻 Pages: 567-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis of 6-N( benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism2010
- Author(s)
  Y. Masaki, H.A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. 18
  
  Pages: 567-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Linear relationship between deformability and thermal stability of 2'-O-modified RNA hetero duplexes2010
- Author(s)
  Y.Masaki, H.A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 114 Pages: 567-572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010
- Author(s)
  Y. Masaki, R. Miyasaka, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  J. Phys. Chem.(B)
  
  Volume: 114巻 Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3'-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N3-cyano-ethylthymine2010
- Author(s)
  H. Tsunoda, T. Kudo, A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Molecules
  
  Volume: 15 Pages: 7509-7531
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions2010
- Author(s)
  A. Ohkubo, Y. Kuwayama, Y. Nishino, H. Tsunoda, K. Seio, M. Sekine
- Journal Title
  
  Org. Lett. 12
  
  Pages: 2496-2499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis and hybridization properties of oligonucleotides incorporating Bi- and Tri-cyclic cytosine derivatives2010
- Author(s)
  A. Ohkubo, T. Sakaue, H. Tsunoda, K. Seio, M. Sekine
- Journal Title
  
  Chem. Lett. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis of oligodeoxynucleotides using the oxidatively cleavable 4-methoxytritylthio (MMTrS) group for protection of the 5 '-hydroxyl group2010
- Author(s)
  K. Seio, M. Shiraishi, E. Utagawa, A. Ohkubo, M. Sekine;
- Journal Title
  
  New J. Chem. 34
  
  Pages: 984-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Linear Relationship between Deformability and Thermal Stability of 2'-O-Modified RNA Hetero Duplexes2010
- Author(s)
  Y.Masaki, R.Miyasaka, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  J.Phys.Chem.(B) 114
  
  Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue : crystal structures of DNA duplexes containing 7, 8-dihydropyrido[ 2, 3-d] pyrimidin-2-one. E. C. M. Juan2010
- Author(s)
  S. Shimizu, X. Ma, T. Kurose, T. Haraguchi, F. Zhang, M. Tsunoda, A. Ohkubo, M. Sekine, T. Shibata, C. L. Millington, D. M. Williams, A. Takenaka
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 6737-6745
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis and hybridization properties of oligonucleotides incorporating Bi- and Tri-cyclic cytosine derivatives2010
- Author(s)
  A.Ohkubo, T.Sakaue, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Chemistry Letters
  
  Volume: 39 Pages: 726-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Linear relationship between deformability and thermal stability of 2 '-O-modified RNA hetero duplexes2010
- Author(s)
  Y. Masaki, H.A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  J. Phys. Chem. B. 114
  
  Pages: 2517-2524
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions2010
- Author(s)
  A.Ohkubo, Y.Kuwayama, Y.Nishino, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Organic Letters
  
  Volume: 12 Pages: 2496-2499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22750146
[Journal Article] Synthesis and triplex formation of oligonucleotides containing 8-thioxodeoxyadenosine2009
- Author(s)
  K. Miyata, R. tamamushi, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Org. Lett. 11
  
  Pages: 605-608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Introduction of 3'-Terminal Nucleosides Having a Silyl Linker into Polymer Supports without Base Protection2009
- Author(s)
  A.Ohkubo, Y.Noma, K.Aoki, H.Tsunoda, K.Seio, M Sekine
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009
- Author(s)
  K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A. Ohkubo, R. Kasuya, K. Aoki, A. Kobori, H. Taguchi, K. Seio, M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. 17
  
  Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Fluorescence properties of pyrimidopyrimidoindole nucleoside dC(PPI)incorporated into oligodeoxynudeotides2009
- Author(s)
  M.Mizuta, K.Seio, A.Ohkubo, M.Sekine
- Journal Title
  
  J.Phys.Chem.B 113
  
  Pages: 9562-9569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] New thermolytic carbamoyl groups for the protection of nucleobases2009
- Author(s)
  A. Ohkubo, R. Kasuya, K. Miyata, H. Tsunoda, K. Seio, M. Sekine
- Journal Title
  
  Org. Biomol. Chem. 7
  
  Pages: 687-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U. G base pair2009
- Author(s)
  K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009
- Author(s)
  K.Seio, R.Tawarada, T.Sasami, M.Serizawa, M.Ise, A.Ohkubo, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] icrowave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009
- Author(s)
  Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, and M. Sekine
- Journal Title
  
  Org. Lett
  
  Volume: 11巻 Pages: 5582-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Fluorescence properties of pyrimidopyrimidoindole nucleoside dC(PPI) incorporated into oligodeoxynucleotides.2009
- Author(s)
  M. Mizuta, K. Seio, A. Ohkubo, M. Sekine
- Journal Title
  
  J. Phys. Chem. B. 113
  
  Pages: 9562-9569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A.Ohkubo, K.Sasaki, Y.Noma, H.Tsunoda, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Introduction of 3 '-terminal nucleosides having a silyl-type linker into polymer supports without base protection2009
- Author(s)
  A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio, Sekine
- Journal Title
  
  J. Org. Chem. 74
  
  Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Microwave-assisted synthesis of 2 '-O-aryluridine derivatives2009
- Author(s)
  Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine
- Journal Title
  
  Org. Lett. 11
  
  Pages: 5682-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis and hybridization of 2'-O-methyl-RNAs incorporating 2'-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair2009
- Author(s)
  K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, M. Sekine
- Journal Title
  
  Bioorg. Med. Chem 17
  
  Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Introduction of 3'-terminal nucleosides having a silyl-type linker into polymer supports with out base protection2009
- Author(s)
  Ohkubo A, Noma Y, Aoki K, Tsunoda H, Seio K, Sekine M
- Journal Title
  
  Journal of the Organic Chemistry 74
  
  Pages: 2817-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] 3'-Terminal Nucleosides Having a SilylLinker into Polymer Supports without Base Protection2009
- Author(s)
  A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio and M. Sekine
- Journal Title
  
  J. Org. Chem
  
  Volume: 74巻 Pages: 2817-2823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Microwave-Assisted Synthesis of 2'-O-Aryluridine Derivatives2009
- Author(s)
  Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5582-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl)benzoyl group2009
- Author(s)
  K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, M.
- Journal Title
  
  Sekine; Bioorg. Med. Chem. 17
  
  Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2,2,7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A.Ohkubo, R.Kasuya, K.Aoki, A.Kobori, H.Taguchi, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 7275-7280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K. Seio, Y. Takaku, K. Miyazaki, S. kurohagi, Y. Masaki, A. Ohkubo, M. Sekine
- Journal Title
  
  Org. Biomol. Chem. 7
  
  Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K.Seio, Y.Takaku, K.Miyazaki, Y.Masaki, A.Ohkubo, M.Sekine
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis of terminally modifiedoligonucleotides and their hybridization dependence on the size of the target RNAs2009
- Author(s)
  K. Seio, Y. Takaku, K. Miyazaki, Y. Masaki, A. Ohkubo, and M. Sekine
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 7巻 Pages: 2440-2451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Synthesis and Properties of Nucleoside Derivatives Masked by the Chemically Stable 2-(Trimethylsilyl) benzoyl Group2009
- Author(s)
  K.Yamada, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 5928-5932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] Microwave-assisted synthesis of 2'-O-aryluridine derivatives2009
- Author(s)
  Y.Oeda, Y.Iijima, H.Taguchi, A.Ohkubo, K.Seio, M.Sekine
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5682-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Efficient solid-phase synthesis of oligodeoxynucleotides having a 5'-terminal 2, 2, 7-trimethylguanosine pyrophosphate linkage2009
- Author(s)
  A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, and M. Sekine
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 17巻 Pages: 4819-4824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21241053
[Journal Article] New thermolytic carbamoyl groups for the protection of nucleobases2009
- Author(s)
  Ohkubo A, Kasuya R, Miyata K, Tsunoda H, Seio K, Sekine M.
- Journal Title
  
  Organic & biomolecular chemistry 7
  
  Pages: 687-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Protected DNA Probes' capable of strong hybridization without removal of base protecting groups2008
- Author(s)
  Ohkubo A, Kasuya R, Sakamoto K, Miyata K, Taguchi H, Nagasawa H, Tsukahara T, Watanobe T, Maki Y, Seio K, Sekine M.
- Journal Title
  
  Nucleic Acids Research 36
  
  Pages: 1952-1964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues2008
- Author(s)
  K. Seio, M. Mizuta, K. Tasaki, K. Tamaki, A. Ohkubo, M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 8287-8293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker2008
- Author(s)
  A. Ohkubo, R. Kasuya, K. Aoki, A. Kobori, H. Taguchi, K. Seio, M.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 5345-5351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] O-selective condensation using P-N bond cleavage in RNA synthesis without base protection2008
- Author(s)
  A. Ohkubo, Y. Kuwayama, T. Kudo, H. Tsunoda, K. Seio, M
- Journal Title
  
  Org. Lett. 10
  
  Pages: 2793-2796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis and properties of DNA oligomers containing 2'-deoxynucleoside-N-oxide derivatives2008
- Author(s)
  H. Tsunoda, A. Ohkubo, H. Taguchi, K. Seio, Sekine
- Journal Title
  
  J. Org. Chem. 73
  
  Pages: 1217-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction2008
- Author(s)
  M. Mizuta, J. Banba, T. Kanamori, R. Tawarada, A. Ohkubo, M. Sekine, K. Seio
- Journal Title
  
  J. Am. Chem. Soc. 130
  
  Pages: 9622-9623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] "Protected DNA Probes (PDP)" capable of strong hybridization without removal of base protecting groups2008
- Author(s)
  A. Ohkubo, R. Kasuya, K. Sakamoto, K. Miyata, H. Taguchi, H. Nagasawa, T. Tsukahara, T. Watanobe, Yoshiyuki Maki, Kohji Seio, Mitsuo Sekine
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1952-1964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20750129
[Journal Article] Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives2007
- Author(s)
  Miyata K, Mineo R, Tamanushi R, Mizuta M, Ohkubo A, Taguchi H, Seio K, Santa T, Sekine M
- Journal Title
  
  JOURNAL OF ORGANIC CHEMISTRY 72(1)
  
  Pages: 102-108
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Synthesis of branched oligonucleotides with three different sequences using an oxidatively removable tritylthio group2007
- Author(s)
  E. Utagawa, A. Ohkubo, M. Sekine, K. Seio
- Journal Title
  
  Journal of the Organic Chemistry 72
  
  Pages: 8259-8266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-Acetyl-3-deazaguanine, in 2'-O-Methyl-RNA/RNA and DNA duplexes2007
- Author(s)
  Seio K, Sasami T, Ohkubo A, Ando K, Sekine M
- Journal Title
  
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(5)
  
  Pages: 1026-1027
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] An effective method for the in situ synthesis of DNA・CPG conjugates using chemical ligation technology as tools for SNP analysis2007
- Author(s)
  A. Ohkubo, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara M. Sekine
- Journal Title
  
  Bioorganic Medicinal Chemistry Letters 17
  
  Pages: 5969-5973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis2007
- Author(s)
  A. Ohkubo, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara, M. Sekine
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 5147-5150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative2006
- Author(s)
  Miyata K, Tamanushi R, Ohkubo A, Taguchi H, Seio K, Santa T, Sekine M
- Journal Title
  
  ORGANIC LETTERS 8 (8)
  
  Pages: 1545-1548
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage2006
- Author(s)
  Taguchi H, Ohkubo A, Sekine M, Seio K, Kakeya H, Osada H
- Journal Title
  
  NUCLEOSIDES NUCLEOTIDES ＆ NUCLEIC ACIDS 25 (4-6)
  
  Pages: 647-654
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Conformational studies of 4-N-carbamoyldeoxycytidine derivatives and synthesis and hybridization properties of oligodeoxyribonucleotides incorporating these modified bases2006
- Author(s)
  Miyata K, Kobori A, Tamanushi R, Ohkubo A, Taguchi H, Seio K, Sekine M
- Journal Title
  
  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 16
  
  Pages: 3626-3637
- Data Source
  KAKENHI-PROJECT-18750144
[Journal Article] Synthesis and properties of cationic 2'-O-[ N-(4-aminobutyl) carbamoyl] modified oligonucleotides.
- Author(s)
  K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, M. Sekine
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] Development of a method for chemical synthesis of long DNAs in a photolithographic flow system2023
- Author(s)
  Koichiro Miyauchi, Teruyuki Okaniwa, Koki Maruyama, Ishin Ono, Tatsuhiro Yokoyama, Aoma Yoshida, Akihiro Ohkubo
- Organizer
  第50回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26772
[Presentation] 2’-O-ビニルRNAホスホロアミダイトユニットの合成および核酸合成法への応用検討2023
- Author(s)
  大野維新・大河原佑哉・並木優典・久恒一賜・宗像功太郎・宮内幸一郎・大窪章寛
- Organizer
  第13回CSJ化学フェスタ2023
- Data Source
  KAKENHI-PROJECT-23K26772
[Presentation] Chemical synthesis of oligonucleotides using 2’-O-vinyl RNA phosphoramidite units2023
- Author(s)
  Yuya Okawara, Ishin Ono, Yusuke Namiki, Kazushi Hisatsune, Kotaro Munakata, Koichiro Miyauchi, Akihiro Ohkubo
- Organizer
  第50回国際核酸化学シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26772
[Presentation] Synthesis and properties of triplex-forming oligonucleotides containing modified sugar moieties and nucleobases.2018
- Author(s)
  S. Nishizawa, T. Ohnishi, L. Watanabe, T. Kanamori, H. Yuasa, A. Ohkubo
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] Synthesis and properties of cyclic oligonucleotides containing acyl groups at the 5'- and 3'- terminal sites.2018
- Author(s)
  R. Hashimoto, S. Nishizawa, Y. Miyake, T. Kanamori, H. Yuasa, A. Ohkubo
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] 5´および3´にアシル基を有する環状オリゴヌクレオチドの合成2017
- Author(s)
  西澤周平、橋本律、金森功吏、湯浅英哉、大窪章寛
- Organizer
  日本化学会　春季年会
- Place of Presentation
  慶応大学
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] イソフタル酸誘導体を有する新規修飾核酸の合成と性質2017
- Author(s)
  西村ゆり、Kaewsomboon TANASAK、金森功吏、湯浅英哉、大窪章寛
- Organizer
  日本薬学会春季年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] Synthesis and properties of new modified oligonucleotides containing amino groups at the 5´-positions of ribose moieties2017
- Author(s)
  Tomohiro Aoyama, Kosuke Muto, Lintaro Watanabe, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo
- Organizer
  International Symposium of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] U1 snRNA 誘導体の合成2017
- Author(s)
  細谷輝、金森功吏、湯浅英哉、大窪章寛
- Organizer
  日本薬学会春季年会
- Place of Presentation
  仙台国際センター
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] Synthesis and properties of cyclic oligonucleotides containing acyl groups at the 5´- and 3´-terminal sites.2017
- Author(s)
  Tanasak kaewsomboon, Shuhei Nishizawa, Ritsu Hashimoto, Yu Miyake, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo
- Organizer
  International Symposium of Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05840
[Presentation] Synthesis of oligodeoxynucleotides incorporating conformational restriction at the 5’-terminus and their application to discrimination of RNA length variants2013
- Author(s)
  Yoshihiro Iijima, Sayako Kurohagi, Erika Kodama, Shun Kojima, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio
- Organizer
  The 40th international symposium on nucleic acids chemistry
- Place of Presentation
  Kanagawa University (Yokohama)
- Data Source
  KAKENHI-PROJECT-24550184
[Presentation] Chemical synthesis of U1 snRNA derivatives2013
- Author(s)
  Haruki Kobayashi, Akihiro Ohkubo, Makoto Suzuki, Takashi Kanamori, Yoshiaki Masaki, Kohji Seio, Mitsuo Sekine, Hideya Yuasa
- Organizer
  The 40th international symposium on nucleic acids chemistry
- Place of Presentation
  Kanagawa University (Yokohama)
- Data Source
  KAKENHI-PROJECT-24550184
[Presentation] Synthesis and properties of new triplex forming oligonucleotides capable of recognizing TA and CG base pairs in parallel orientation2012
- Author(s)
  Kenji Yamada, Yu Ito, Kiichi Yoshimura, Takashi Kanamori, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
- Organizer
  The 39th International Symposium onNucleic Acids Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-24550184
[Presentation] Development of fluorescent turn-on sensor for triplex formation and its application to nucleosides and oligonucleotides sensing2012
- Author(s)
  Takashi Kanamori, Hiroki Ohzeki, Yuki Oda, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio
- Organizer
  The 39th International Symposium onNucleic Acids Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-24550184
[Presentation] 6-チオプリンおよび4-チオピリミジン誘導体を含むオリゴヌクレオチドの合成とその三重鎖形成能2012
- Author(s)
  服部勇作・印出健志・山田健司・伊藤優・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] DNA二重鎖および三重鎖に導入したデオキシシュードイソシチジンの塩基対形成能の評価2012
- Author(s)
  金森功吏・山口慧・角田浩佑・大窪章寛・関根光雄・清尾康志
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 4-O-(アミノエチル)ウリジン誘導体を含む新規三重鎖形成核酸の合成とその性質2012
- Author(s)
  伊藤優・山田健司・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第92春季年会
- Place of Presentation
  慶應大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synthesis and Properties of Oligonucleotides having 5'-terminal 2, 2, 7-trimethylguanosine cap Analogues 6th Cambridge Symposium on Nucleic Acids Chemistry and Biology2011
- Author(s)
  Akihiro Ohkubo, Akira Yokouchi, Ken Yamada, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  Queens' College
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] Synthesis and triplex formation of RNAs containing 8-thioxoadenine and 2-thiopyrimidine RNA20112011
- Author(s)
  Akihiro Ohkubo, Yu Ito, Yudai Nishino, Akira Yokouchi, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  the 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] Synthesis and Properties of Oligonucleotides Having 5'-Terminal 2, 2, 7-Trimethylguanosine cap Analogues RNA20112011
- Author(s)
  Akira Yokouchi, Ken Yamada, Hirosuke Tsunoda, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine.
- Organizer
  the 16th Annual Meeting of the RNA Society and The RNA Society of Japan 13th Annual Meeting
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] Synthesis and Properties of Oligonucleotides having 5'-terminal 2, 2, 7-trimethylguanosine cap Analogues2011
- Author(s)
  Akihiro Ohkubo, Akira Yokouchi, Ken Yamada, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  7th Annual Meeting of the Oligonucleotide Therapeutics Society
- Place of Presentation
  The Royal Library, Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] TMGキャップアナロクを有するモルフォリノ核酸の合成2011
- Author(s)
  山田研・横内瑛・鈴木真・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  第21回アンチセンスシンポジウムおよび第11回遺伝子・デリバリー研究会シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synthesis and properties of oligonucleotides having 5'-terminal 2, 2, 7-trimethylguanosine cap analogues2011
- Author(s)
  Akihiro Ohkubo, Akira Yokouchi, Ken Yamada, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  Sixth Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Cambridge, UK
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] 塩基性条件下不安定な機能性RNAの新規合成法の開発2010
- Author(s)
  大窪章寛、角田浩佑、清尾康志、関根光雄
- Organizer
  第98回有機合成シンポジウム
- Place of Presentation
  早稲田大学
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] 2'-O-MCEオリゴヌクレオチドの合成と性質2010
- Author(s)
  山田剛史、岡庭夏己、武田伸一、永田哲也、實吉尚郎、大窪章寛、関根光雄
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Relationship Between Thermal Stability and Deformability of Modified RNA, XIX International Round Table on Nucleosides2010
- Author(s)
  正木慶昭・宮坂隆太・角田浩佑・大窪章寛・清尾康志・関根光雄
- Organizer
  Nucleotides and Nucleic Acids
- Place of Presentation
  クロードベルナールリヨン第一大学
- Year and Date
  2010-09-01
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] 2-チオピリミジンおよび8-チオキソプリンを含む修飾RANの三2010
- Author(s)
  大窪章寛、西野雄大、柿島祐樹、正木慶昭、角田浩佑、清尾康志、関根光雄
- Organizer
  重鎖形成能第12回日本RNA学会年会
- Place of Presentation
  一橋記念講堂:学術総合センター
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] Synthesis and triplex formation of oligonucleotides containing 8-thioxoadenine 2-thiopyrimidine2010
- Author(s)
  A.Ohkubo, Y.Nishino, Y.Kakishima, H.Tsunoda, K.Seio, M.Sekine
- Organizer
  XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Lyon (France)
- Year and Date
  2010-09-01
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] ホスホロアミダイト化合物を利用した新規ピロリン酸化反応の開発2010
- Author(s)
  大窪章寛、西野雄大、角田浩佑、清尾康志、関根光雄
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  近畿大学
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Synergetic effects of 2-thiolation and 5-propynylation of the uracil base on the stability of RNA duplexes2010
- Author(s)
  R. Miyasaka, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, and M. Sekine
- Organizer
  第37回国際核酸化学シンポジウム
- Place of Presentation
  よこはま・はまぎんホール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] Synthesis and Properties of 2'-O-[ 2-(N-methyl) carbamoyl] ethyl-RNAs2010
- Author(s)
  T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, S. Takeda, and M. Sekine
- Organizer
  第37回国際核酸化学シンポジウム
- Place of Presentation
  よこはま・はまぎんホール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21241053
[Presentation] SYNTHESIS AND TRIPLEX FORMING OF OLIGONUCLEOTIDES CONTAINING 8-THIOXOADENINE AND 2-THIOPYRIMIDINE IRT 2010-XIX2010
- Author(s)
  Akihiro Ohkubo, Yudai Nishino, Yuki Kakishima, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Batiment CPE(Rue Victor Grignard), Universite Claude Bernard Lyon 1, France
- Data Source
  KAKENHI-PROJECT-22750146
[Presentation] 次世代のRNAテクノロジーを支える革新的核酸合成法の開発2010
- Author(s)
  大窪章寛
- Organizer
  日本化学会第90回春季年会
- Place of Presentation
  近畿大学(近畿大学)
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] 末端にジリン酸結合を介してアデニル化されたオリゴヌクレオチドの効率合成法の開発2009
- Author(s)
  大窪章寛、西野雄大、野間靖弘、桑山靖和、角田浩佑、清尾康志、関根光雄
- Organizer
  第11回RNAミーティング
- Place of Presentation
  朱鷺メッセ・新潟コンベンションセンター
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Synthesis and triplex formation of oligonucleotides containing 8-thioxodeoxyadenosine and 5-methyl-2-thiodeoxycytosine2009
- Author(s)
  Akihiro Ohkubo, Kenichi Miyata, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  国際核酸医薬シンポジウム第5回OTS年会第19回アンチセンスシンポジウム合同シンポジウム
- Place of Presentation
  九州大学
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] 機能性RNA分子の合成を指向した酸脱保護RNA合成法の開発2009
- Author(s)
  桑山靖和、大窪章寛、西野雄大、角田浩佑、清尾康志、関根光雄
- Organizer
  第11回RNAミーティング
- Place of Presentation
  朱鷺メッセ・新潟コンベンションセンター
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Evaluation of base recognition abilities of 2'-deoxynucleoside N-oxide derivatives by polymerase reactions2009
- Author(s)
  Hirosuke Tsunoda, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine
- Organizer
  第6回国際核酸化学シンポジウム
- Place of Presentation
  岐阜県高山市民文化会館
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Synthesis and triplex formation of oligonucleotides containing 8-thioxodeoxyadenosine and 5-methyl-2-thiodeoxycytosine2009
- Author(s)
  Akihiro Ohkubo, Kenichi Miyata, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
- Organizer
  第6回国際核酸化学シンポジウム
- Place of Presentation
  岐阜県高山市民文化会館
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Development of new methods for the synthesis of RNA oligonucleotides having base-labile functional groups2008
- Author(s)
  大窪章寛
- Organizer
  18^<th> International roundtable on nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  京都大学
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-20750129
[Presentation] Development an N-unprotected phosphoramidite method for the chemical synthesis of aminoacylated RNAs2007
- Author(s)
  大窪章寛
- Organizer
  5th International Symposium on Nucleic Adds Chemistry
- Place of Presentation
  東京大学
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18750144

1. SEKINE Mitsuo (40111679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 37 results
2. 清尾康志

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
3. 湯浅英哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ookubo Akihiro 大窪 章寛

Ohkubo Akihiro 大窪 章寛

OHKUBO Akihiro 大窪 章寛

Research Projects

Research Products

Co-Researchers

RNAアプタマーアレイを用いた修飾RNAの分子進化Principal Investigator

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Development of modified U1 snRNA derivatives as new nucleic acid drugsPrincipal Investigator

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Development of a new method for chemical synthesis of genomic DNAsPrincipal Investigator

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Development of artificial aminoacylated tRNA with high efficiency of turnoverPrincipal Investigator

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Exploration of Innovative Methods for the synthesis of RNA Capable of Machting Requirement for New day

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Development of a new method for chemical synthesis of aminoacylated tRNA.Principal Investigator

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ゲノムDNAの精密有機化学合成Principal Investigator

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[Book] 新しいDNAチップの科学と応用2007

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[Book] "ファイバー"スーパーバイオミメティックス(本宮 達也 監)2006

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[Journal Article] Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine2018

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[Journal Article] pH-Dependent Switching of Base Pairs Using Artificial Nucleobases with Carboxyl Groups2018

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[Journal Article] Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect2017

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[Journal Article] Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation2017

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[Journal Article] Enzymatic synthesis and reverse transcription of RNAs incorporating 2 -O-carbamoyl uridine triphosphate2016

Author(s)

Ookubo Akihiro 大窪章寛

Ohkubo Akihiro 大窪章寛

OHKUBO Akihiro 大窪章寛

[Book] "ファイバー"スーパーバイオミメティックス(本宮達也監)2006