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Takemoto Masaya  武本 眞清

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TAKEMOTO Masaya  武本 眞清

武本 眞清  タケモト マサヤ

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Researcher Number 60379237
Affiliation (Current) 2025: 北陸大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 北陸大学, 薬学部, 准教授
2016 – 2020: 北陸大学, 薬学部, 講師
2010 – 2011: 富山大学, 大学院・医学薬学研究部(医学), 助教
2010: 医薬基盤研究所, 基盤研究部, 研究員
2008: 独立行政法人医薬基盤研究所, 基盤研究部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Virology
Except Principal Investigator
Virology
Keywords
Principal Investigator
水痘帯状疱疹ウイルス / Tricin / 急性網膜壊死 / tricin / 単純ヘルペスウイルス / CCL20 / 炎症性腸疾患 / サイトメガロウイルス / Foscarnet / foscarnet … More / HSV / VZV / アメナメビル / アシクロビル / 網膜色素上皮細胞 / iPS細胞 / 網膜オルガノイド / 母子感染 / 再活性化 / 水筒帯状疱疹ウイルス / マトリックスメタロプロテアーゼ / ケモカイン / 網膜ミュラー細胞 / acyclovir / 小胞体ストレス / glycoprotein H (gH) / glycoprotein H / オートファジー / shedding microvesicles / 抗原変調AV3(antigenic modulation) … More
Except Principal Investigator
帯状疱疹 / 抗原偏重作用 / クロマチン / 転写因子 / ウィルス / ウイルス感染性 / 中和抗体 / 潜伏感染 / 抗原変調 / 水痘帯状疱疹ウイルス / 病原性 / ウイルス感染 / 細胞向性 / 遺伝子発現 Less
  • Research Projects

    (6 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (13 People)
  •  ヒトサイトメガロウイルスによるケモカインCCL20を介した炎症性腸疾患の病態解析Principal Investigator

    • Principal Investigator
      武本 眞清
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Hokuriku University
  •  Analysis of pathogenesis of acute retinal necrosis using retinal organoidsPrincipal Investigator

    • Principal Investigator
      Takemoto Masaya
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Hokuriku University
  •  An applicable study of tricin for prevention and treatment of alphaherpesviral infections diseasesPrincipal Investigator

    • Principal Investigator
      Takemoto Masaya
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Hokuriku University
  •  Analysis of VZV latency induced by antigenic modulation

    • Principal Investigator
      Shiraki Kimiyasu
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      University of Toyama
  •  Analysis of mechanism of latent infection and reactivation of varicella-zoster virusPrincipal Investigator

    • Principal Investigator
      TAKEMOTO Masaya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      University of Toyama
  •  Identification and functional analysis of factors related to human herpesvirus pathogenesis

    • Principal Investigator
      MORI Yasuko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Kobe University

All 2023 2022 2019 2018 2017 2016 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] An in silico-designed flavone derivative, 6-fluoro-4′-hydroxy-3′,5′-dimethoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells2018

    • Author(s)
      Kazuhiro J. Fujimoto, Daiki Nema, Masayuki Ninomiya, Mamoru Koketsu, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
    • Journal Title

      Antivir. Res.

      Volume: 154 Pages: 10-16

    • DOI

      10.1016/j.antiviral.2018.03.006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K05670, KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587, KAKENHI-PROJECT-16K09929
  • [Journal Article] Tricin inhibits CCL5 induction required for the efficient growth of human cytomegalovirus2018

    • Author(s)
      Akimasa Itho, Hidetaka Sadanari, Masaya Takemoto, Keiko Matsubara, Tohru Daikoku, Tsugiya Murayama
    • Journal Title

      Microbiology and Immunology

      Volume: 62 Issue: 5 Pages: 341-347

    • DOI

      10.1111/1348-0421.12590

    • NAID

      40021560453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-16K09929
  • [Journal Article] The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 92018

    • Author(s)
      Hidetaka Sadanari, Kazuhiro J. Fujimoto, Yuto Sugihara, Tomoki Ishida, Masaya Takemoto, Tohru Daikoku, Tsugiya Murayama
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 4 Pages: 646-654

    • DOI

      10.1002/2211-5463.12398

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K05670, KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587, KAKENHI-PROJECT-16K09929
  • [Journal Article] Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir2017

    • Author(s)
      Tohru Daikoku, Mineyuki Mizuguchi, Takayuki Obita, Takeshi Yokoyama, Yoshihiro Yoshida, Masaya Takemoto, Kimiyasu Shiraki
    • Journal Title

      Journal of Microbiology, Immunology and Infection

      Volume: 印刷中 Issue: 5 Pages: 30100-7

    • DOI

      10.1016/j.jmii.2017.03.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09929, KAKENHI-PROJECT-25293108, KAKENHI-PROJECT-16K09948
  • [Journal Article] Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor.2017

    • Author(s)
      Misako Yajima, Hiroshi Yamada, Masaya Takemoto, Tohru Daikoku, Yoshihiro Yoshida, Tan Long, Tomoko Okuda, Kimiyasu Shiraki.
    • Journal Title

      Antiviral Research

      Volume: 139 Pages: 95-101

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Journal Article] Interaction of immunoglobulin with cytomegalovirus-infected cells.2017

    • Author(s)
      Nobuyasu Aiba, Atsuko Shiraki, Misako Yajima, Yukari Oyama, Yoshihiro Yoshida, Ayumu Ohno, Hiroshi Yamada, Masaya Takemoto, Tohru Daikoku, Kimiyasu Shiraki
    • Journal Title

      Viral Immunology

      Volume: 印刷中 Issue: 7 Pages: 500-507

    • DOI

      10.1089/vim.2016.0151

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-25293108
  • [Journal Article] Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir2017

    • Author(s)
      Tohru Daikoku, Mineyuki Mizuguchi, Takayuki Obita, Takeshi Yokoyama, Yoshihiro Yoshida, Masaya Takemoto, and Kimiyasu Shiraki
    • Journal Title

      Journal of Microbiology, Immunology and Infection

      Volume: 印刷中

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293108
  • [Journal Article] Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression2017

    • Author(s)
      Yumiko Akai, Hidetaka Sadanari, MasayaTakemoto, Noboru Uchide, Tohru Daikoku, Naofumi Mukaida, Tsugiya Murayama
    • Journal Title

      Antiviral Research

      Volume: 148 Pages: 15-19

    • DOI

      10.1016/j.antiviral.2017.09.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09948, KAKENHI-PROJECT-15K09587
  • [Journal Article] Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor2017

    • Author(s)
      Yajima Misako、Yamada Hiroshi、Takemoto Masaya、Daikoku Tohru、Yoshida Yoshihiro、Long Tan、Okuda Tomoko、Shiraki Kimiyasu
    • Journal Title

      Antiviral Res

      Volume: 139 Pages: 95-101

    • DOI

      10.1016/j.antiviral.2016.12.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293108
  • [Journal Article] Rapid detection of human cytomegalovirus UL97 and UL54 mutations for antiviral resistance in clinical specimens2013

    • Author(s)
      Tohoru Daikoku, Kazuhide Saito, Takamitsu Aihara, Masahiro Ikeda, Yoshiyuki Takahashi, Hiroki Hosoi, Tetsuya Nishida, Masaya Takemoto,Kimiyasu Shiraki.
    • Journal Title

      Microbiol Immunol

      Volume: 57 Issue: 5 Pages: 396-399

    • DOI

      10.1111/1348-0421.12043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249078, KAKENHI-PROJECT-25293108, KAKENHI-PROJECT-25461508
  • [Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo2012

    • Author(s)
      Takehiro Himaki, Yumi Masui, Koji Chono, Tohru Daikoku, Masaya Takemoto, Bo Haixia, Tomoko Okuda, Hiroshi Suzuki, Kimiyasu Shiraki
    • Journal Title

      Antiviral Research

      Volume: 93-2 Pages: 301-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Journal Article] Neutralizing anti-gH antibody of Varicella-zoster virus modulates distribution of gH and induces gene regulation, mimicking latency2011

    • Author(s)
      Kimiyasu Shiraki, Tohru Daikoku, Masaya Takemoto, Yoshihiro Yoshida, Kazuhiro Suzuki, Yasushi Akahori, Toshiomi Okuno, Yoshikazu Kurosawa, and Yoshizo Asano
    • Journal Title

      Journal of Virology

      Volume: 85-16 Pages: 8172-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Journal Article] Characterization of a fully human monoclonal antibody against extracellular domain of matrix protein 2 of influenza A virus2011

    • Author(s)
      Tatsuhiko Ozawa, Aishun Jin, Kazuto Tajiri, Masaya Takemoto, Tomoko Okuda, Kimiyasu Shiraki, Hiroyuki Kishi, Atsushi Muraguchi
    • Journal Title

      Antiviral Research

      Volume: 91-3 Pages: 283-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Journal Article] Novel anticytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir2010

    • Author(s)
      Takashi Kuramoto, Tohru Daikoku, Yoshihiro Yoshida, Masaya Takemoto, Kumi Oshima, Yoshito Eizuru, Yoshinobu Kanda, Toshio Miyawaki and Kimiyasu Shiraki
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 333-3 Pages: 816-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Journal Article] Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4(+)T cells2009

    • Author(s)
      Takemoto M, Imasawa T, Yamanishi K, Mori Y.
    • Journal Title

      Virology 385

      Pages: 294-302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390138
  • [Journal Article] Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4(+) T cells.2009

    • Author(s)
      Takemoto M, Imasawa T, Yamanishi K, Mori Y.
    • Journal Title

      Virology. 15;385(2)

      Pages: 294-302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390138
  • [Presentation] ヒトサイトメガロウイルス91-7S株のケモカイン産生誘導に関与する遺伝子解析2023

    • Author(s)
      比嘉友依理、谷内田侑里、廣田 琴、籠 希美、大黒徹、武本眞清
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-23K07953
  • [Presentation] ヒトサイトメガロウイルス91-7S株によるケモカイン産生誘導と遺伝子解析2022

    • Author(s)
      武本眞清、堀場千尋、伊藤真子、増田雪花、定成秀貴、村山次哉、大黒徹
    • Organizer
      日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-19K08965
  • [Presentation] ヒト網膜細胞株におけるHSV-1およびVZVに対する抗ヘルペスウイルス薬の効果比較2022

    • Author(s)
      鈴木はる奈、田中ひなの、嶺井華、大黒徹、武本眞清
    • Organizer
      日本薬学会
    • Data Source
      KAKENHI-PROJECT-19K08965
  • [Presentation] ヒト網膜由来細胞株における抗水痘帯状疱疹ウイルス薬の比較検討2019

    • Author(s)
      武本眞清、定成秀貴、松原京子、村山次哉、大黒徹
    • Organizer
      第67回日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-19K08965
  • [Presentation] Proinflammatory responses to VZV infection in human retinal cell lines.2018

    • Author(s)
      Masaya Takemoto, Chikako Yasumura, Kaede Sawano, Toshimi Satoh, Hidetaka Sadanari, Keiko Matsubara, Tsugiya Murayama, Tohru Daikoku
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] 強力な抗ヒトサイトメガロウイルス活性を有する新規化合物の創薬2017

    • Author(s)
      村山次哉、根間大貴、藤本和宏、纐纈守、二ノ宮真之、定成秀貴、武本眞清、大黒徹
    • Organizer
      第65回日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] Tricinは単純ヘルペスウイルス1型・2型、ならびに水痘帯状疱疹ウイルスの増殖を抑制する2017

    • Author(s)
      武本眞清、定成秀貴、大黒徹、松原京子、村山次哉
    • Organizer
      第65回日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] 抗ヒトサイトメガロウイルス活性のあるtricinによるRNA polymerase II C-terminal domainリン酸化の阻害2017

    • Author(s)
      定成秀貴、杉原雄斗、藤本和宏、武本眞清、大黒徹、村山次哉
    • Organizer
      第65回日本ウイルス学会
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] CCL2/CCR2-dependent replication of human cytomegalovirus is inhibited by anti-inflammatory compound tricin2017

    • Author(s)
      Tsugiya Murayama, Daiki Nema, Hidetaka Sadanari, Masaya Takemoto, Tohru Daikoku, Naofumi Mukaida
    • Organizer
      5th Annual Meeting of the International Cytokine & Interferon Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] Tricinは単純ヘルペスウイルスおよび 水痘帯状疱疹ウイルスの増殖を抑制する2016

    • Author(s)
      武本眞清
    • Organizer
      日本薬学会北陸支部第128回例会
    • Place of Presentation
      北陸大学
    • Data Source
      KAKENHI-PROJECT-16K09948
  • [Presentation] 水痘帯状疱疹ウイルスの抗gH中和抗体による潜伏感染誘導時の転写制御2013

    • Author(s)
      武本眞清,大黒 徹,白木公康
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25293108
  • [Presentation] 単純ヘルペスウイルス臨床分離株の次世代シークエンサーによる変異部位の網羅的解析2013

    • Author(s)
      大黒 徹,雄山由香利,矢島美彩子,関塚剛史,黒田 誠,佐多徹太郎,武本眞清,白木公康
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25293108
  • [Presentation] Aberrant VZV glycoproteins traffic modulated by neutralizing anti-gH MAb2011

    • Author(s)
      Masaya Takemoto, Tohru Daikoku, Kazuhiro Suzuki, Yasushi Akahori, Yoshikazu Kurosawa, Yoshizo Asano, Kimiyasu Shiraki
    • Organizer
      36th Annual International Herpesvirus Workshop
    • Place of Presentation
      Gdansk, Poland
    • Year and Date
      2011-07-27
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Aberrant VZA glycoproteins traffic modulated by neutralizing anti-gH MAb2011

    • Author(s)
      Masaya Takemoto
    • Organizer
      36^<th> Annual International Herpesvirus Workshop
    • Place of Presentation
      Gdansk, Poland
    • Year and Date
      2011-07-27
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Aberrant VZV glycoproteins traffic modulated by neutralizing anti-gH MAb, International Union of Microbiological Societies 2011 Congress2011

    • Author(s)
      Masaya Takemoto, Tohru Daikoku, Kazuhiro Suzuki, Yasushi Akahori, Yoshikazu Kurosawa, Yoshizo Asano, Kimiyasu Shiraki
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-13
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Aberrant VZV glycoproteins traffic modulated by neutralizing anti-gH MAb2011

    • Author(s)
      Masaya Takemoto
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-13
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Anti-gH neutralizing antibody alters localization of VZV glycorpoteins B and E2010

    • Author(s)
      Masaya Takemoto
    • Organizer
      International Herpesvirus Workshop
    • Place of Presentation
      University of Utah, USA
    • Year and Date
      2010-07-26
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Anti-gH neutralizing antibody alters localization of VZV glycorpoteins B and E2010

    • Author(s)
      Masaya Takemoto, Tohru Daikoku, Kazuhiro Suzuki, Yasushi Akahori, Yoshikazu Kurosawa, Yoshizo Asano, and Kimiyasu Shiraki
    • Organizer
      35th Annual International Herpesvirus Workshop
    • Place of Presentation
      University of Utah, USA
    • Year and Date
      2010-07-26
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] 水痘・帯状疱疹ウイルスglycoprotein Hに対する中和抗体による、細胞内ウイルスの感染性消失過程の解析2010

    • Author(s)
      武本眞清
    • Organizer
      日本ウイルス学会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2010-11-09
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] 水痘・帯状疱疹ウイルスglycoprotein Hに対する中和抗体による、細胞内ウイルスの感染性消失過程の解析2010

    • Author(s)
      武本眞清,大黒徹,吉田与志博,浅野喜造,白木公康
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2010-11-09
    • Data Source
      KAKENHI-PROJECT-22790428
  • [Presentation] Neutralizing antibody against VZV gH modulates localization of IE62, IE63, and Sp1 during termination of productive infection.

    • Author(s)
      Takemoto M, Daikoku T, Yajima M, Asano Y, Shiraki K.
    • Organizer
      The 39th Annual International Herpesvirus Workshop (IHW)
    • Place of Presentation
      Koube
    • Year and Date
      2014-07-19 – 2014-07-23
    • Data Source
      KAKENHI-PROJECT-25293108
  • 1.  MORI Yasuko (50343257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  OKAMOTO Shigefumi (50311759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Shiraki Kimiyasu (50135745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  DAIKOKU Tohru (80291409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  YAJIMA Misako (60443131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  周尾 卓也 (90399006)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KUROSA Yoshikazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ASANO Yoshizo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  SUZUKI Yasuhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OHNO Ayumu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FUJIMOTO Kazuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 12.  高橋 公太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  斎藤 和英
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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