FUJI Naoko 藤直子 (舟島直子)

… Alternative Names

FUNESHINA N. 藤直子

舟島直子

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Researcher Number	60399483
External Links
Affiliation (Current)	2025: 国立研究開発法人国立成育医療研究センター, 臨床検査部, (非)研究員
Affiliation (based on the past Project Information) *help	2009: 国立成育医療セ 2005 – 2008: 国立成育医療センター(研究所), 共同研究管理室, 流動研究員 2007: 国立成育医療センター研究所, 共同研究管理室, 流動研究員 2004: Natl.Res.Inst.For Child Health. & Dev., Dept.of Surgical Research, Researcher, 共同研究管理室, 流動研究員
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator General surgery / General surgery
Keywords	Principal Investigator 樹状細胞 / 遺伝子導入 / レンチウイルス / 免疫抑制 / ES細胞 / 抗原提示分子 / 臓器移植 / 免疫制御 / 新規免疫抑制化合物 Except Principal Investigator GvHD … More / tolerance / transplantation immunology / allograft / CD28 superagonist antibody / cell therapy / co-stimulatory molecular / regulatory T cell / GVH反応 / 制御リンパ球 / FoxP3 / GvH反応 / 拒絶反応 / 細胞養子移植 / 免疫細胞療法 / 心移植 / 皮膚移植 / PD-L1経路 / PD-1 / CD28superagonist抗体 / 補助シグナル分子 / 制御性Tリンパ球 / DNA chip / co-stimulatory / gene / regulatory cell / isograft / 臓器移植 / DNAチップ / 移植免疫 / 遺伝子 / 補助シグナル / 免疫寛容 / 生体肝移植 Less

ES細胞の制御性樹状細胞への分化誘導および免疫療法の開発に関する研究Principal Investigator
- Principal Investigator
  
  藤直子 (舟島直子)
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  National Research Institute for Child Health and Development
樹状細胞を標的とした新規免疫抑制ペプチドの免疫制御機序解明および臓器移植への応用Principal Investigator
- Principal Investigator
  
  藤直子 (舟島直子)
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  National Research Institute for Child Health and Development
The mechanisms of the induction and maintenance of the transplantation tolerance and usage of the Treg cells as a cellular therapy for treatment allograft rejection and GvHD
- Principal Investigator
  
  RII Ko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  National Research Institute for Child Health and Development
GENE-EXPRESSION PROFILES OF THE PERIPHERAL BLOOD MONONUCLEAR CELLS FROM TOLERANT RAT AND LIVING-DONOR LIVER TRANSPLANT RECIPIENTS
- Principal Investigator
  
  LI X-k.
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  National Research Institute for Child Health and Development

All 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation

[Journal Article] Prolongation of rat major histocompatibihty complex-compatible cardiac allograft survival during pregnancy2009
- Author(s)
  Funeshima-Fuii N, Fujino M, Xie L, Kimura H, Takahara S, Ezaki T, Zhu BT, Li XK.
- Journal Title
  
  J Heart Lung Transplant. Feb;28(2)
  
  Pages: 176-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790941
[Journal Article] Survival of skin allografts is prolonged in mice with a dominantnegative H-Ras2008
- Author(s)
  Funeshima-Fuii N, Fujino M, Kimura H, Takahara S, Nakayama T, Ezaki T, Zhu BT, Li XK
- Journal Title
  
  Transpl Immunol. Feb;18(4)
  
  Pages: 302-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790941
[Journal Article] Foxp3-expressing regulatory T-cells expanded with CD28 superagonist antibody prevent rat cardiac allograft rejection2008
- Author(s)
  Kitazawa Y, Fujino M, Sakai T, Azumu H, Kimura H, Isaka Y, Takahara S, Hunig T, Abe R, Li X-K.
- Journal Title
  
  Journal of Heart and Lung Transplantation 27(4)
  
  Pages: 362-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390355
[Journal Article] Involvement of the PD-1/PD-L1 pathway in CD4+CD25+ regulatory T cells activity to suppress alloimmune responses2007
- Author(s)
  Kitazawa Y, Fujino M, Wang QX, Kimura H, Azuma M, Kubo M, Abe R, Li X-K.
- Journal Title
  
  Transplantation 83(6)
  
  Pages: 774-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390355
[Journal Article] (総説)実験肝移植における免疫寛容の誘導2006
- Author(s)
  藤野真之, 李小康
- Journal Title
  
  Surgery Frontier (In press)
- Data Source
  KAKENHI-PROJECT-17390355
[Journal Article] (総説)実験肝移植における免疫寛容の誘導2006
- Author(s)
  藤野真之, 李小康
- Journal Title
  
  Surge Frontier 13(2)
  
  Pages: 132-36
- Data Source
  KAKENHI-PROJECT-17390355
[Journal Article] Genetic heterogeneity and efficiency of two different methods of adenovirus-mediated gene transfer in a rat liver transplantation model.2006
- Author(s)
  Adachi K, Fujino M, Kitazawa Y, Funeshima N, Li Xk
- Journal Title
  
  Surg Today 36(4)
  
  Pages: 367-375
- Data Source
  KAKENHI-PROJECT-17790902
[Journal Article] Inhibition of allogeneic T cell responses by dendritic cells expressing transduced Indoleamine 2,3-Dioxygenase2005
- Author(s)
  N.Funeshima, M.Fujino, Y.Kitazawa, Y.Hara, Y.Hara, K.Hayakawa, T.Okuyama, H.Kimura, X-K.Li.
- Journal Title
  
  J Gene Med 7(5)
  
  Pages: 565-575
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood.2005
- Author(s)
  Lu FZ, Fujino M, Kitazawa Y, Uyama T, Hara Y, Funeshima N, Jiang JY, Umezawa A, Li XK.
- Journal Title
  
  J Lab Clin Med. Nov;146(5)
  
  Pages: 271-278
- Data Source
  KAKENHI-PROJECT-17790902
[Journal Article] Potential Regulatory Function of Dendritic Cells Overexpression Indoleamine 2,3-Dioxygenase2005
- Author(s)
  Funeshima N, Fujino M, Kitazawa Y, Hara Y, Hayakawa K, Okuyama T, Kimura H, Li XK.
- Journal Title
  
  J Gene Medicine May;7(5)
  
  Pages: 565-575
- Data Source
  KAKENHI-PROJECT-17790902
[Journal Article] The enhanced effects of biodegradable microsphere loaded tacrolimus on mice islet allograft and its reduced adverse effects on insulin secretion.2004
- Author(s)
  QX Wang, T.Uno, Y.Miyamoto, Y.Hara, Y.Kitazawa, FZ Lu, N.Funeshima, M.Fujino, H.Yamamoto, H.Takenaka, Y.Kawashima, X-K.Li.
- Journal Title
  
  Am J Transplant 4(5)
  
  Pages: 721-727
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment result in a distinct tolerant state in rat heart transplantation model2004
- Author(s)
  L Guo, M.Fujino, H.Kimura, N.Funeshima, Y.Kitazawa, Y.Harihara, K.Tezuka, M.Makuuchi, S.Suzuki, X-K.Li.
- Journal Title
  
  Transpl Int 17(1)
  
  Pages: 15-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Differences in lymphocyte gene expression between tolerant and syngeneic liver grafted rats2004
- Author(s)
  M.Fujino, et al.
- Journal Title
  
  Liver Transpl 10(3)
  
  Pages: 379-391
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Differences in lymphocyte gene expression between tolerant and syngeneic liver grafted rats.2004
- Author(s)
  M.Fujino, Y.Kitazawa, M.Kawasaki, N.Funeshima, H.Kimura, T.Nakajima, H.Saito, X-K.Li
- Journal Title
  
  Liver Transpl 10(3)
  
  Pages: 379-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Successful in utero gene transfer using a gene gun in midgestational mouse fetuses.2004
- Author(s)
  J.Yoshizawa J, X-K.Li, M.Fujino, H.Kimura, R.Mizuno, A.Hara, S.Ashizuka, M.Kanai, N.Kuwashima, M.Kurobe, Y.Yamazaki
- Journal Title
  
  J Pediatr Surg. 39(1)
  
  Pages: 81-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] CrmA gene expression protects mice against concanavalin-A induced hepatitis by inhibiting IL-18 secretion and hepatocyte apoptosis.2003
- Author(s)
  M.Fujino, M.Kawasaki, N.Funeshima, Y.Kitazawa, M.Kosuga, K.Okabe, M.Hashimoto, H.Yaginuma, K.Mikoshiba, T.Okuyama, S.Suzuki, X-K.Li
- Journal Title
  
  Gene Ther 10(20)
  
  Pages: 1781-1790
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Prolongation of liver xenograft survival by adenovirus vector-mediated CTLA-4Ig gene transfer.2003
- Author(s)
  L.Guo, X-K.Li, S.Enosawa, Y.Harihara, N.Funeshima, H.Kimura, M.Fujino, M.Makuuchi, S.Suzuki
- Journal Title
  
  Transpl International 11(2)
  
  Pages: 155-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Simultaneous Blockade of Co-stimulatory Signals, CD28 and ICOS, Induced a Stable Tolerance in Rat Heart Transplantation.2003
- Author(s)
  L Guo, M.Fujino, H.Kimura, N.Funeshima, Y.Kitazawa, Y.Harihara, K.Tezuka, M.Makuuchi, S.Suzuki, X-K.Li
- Journal Title
  
  Transpl Immunol 12(1)
  
  Pages: 41-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Prolonged survival of rat liver allograft with adenoviral gene transfection of human immunodeficiency virus type 1(HIV-1) nef.2003
- Author(s)
  M.Fujino, K.Adachi, M.Kawasaki, Y.Kitazawa, N.Funeshima, T.Okuyama, H.Kimura, S.Suzuki, X-K.Li.
- Journal Title
  
  Liver Transpl 9(8)
  
  Pages: 805-813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] Prolonged survival in rat liver transplantation woth mouse monoclonal antibody against an inducible co-stimulator(ICOS).2002
- Author(s)
  L Guo, X-K.Li, N.Funeshima, M.Fujino, Y.Nagata, H.Kimura, H.Amemiya, S.Enosawa, T.Tsuji, Y.Harihara, M.Makuuchi, S.Suzuki
- Journal Title
  
  Transplantation 73(7)
  
  Pages: 1027-1032
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370367
[Journal Article] A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting.
- Author(s)
  Hara Y, Funeshima-Fuji N, Fujino M, Tokunaka K, Abe F, Sato y, Hatakeyama K, Takahara S, Ezaki T, Kimura H, Li XK
- Journal Title
  
  Transplantation (In press)
- Data Source
  KAKENHI-PROJECT-17790902
[Presentation] Attenuate alloimmune response by blockade ras/mitogen-activated protein kinase pathway in T cell2007
- Author(s)
  Funeshima-Fuji N, Fujino M, Kimura H, Nakayama T, Ezaki T, Takahara S, Li X-K.
- Organizer
  13^<th> Congress of the European Society For Organ Transplantation
- Place of Presentation
  Prague
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390355
[Presentation] Attenuate alloimmune response by blockade ras/mitogen-activated protein kinase pathway in T cell2007
- Author(s)
  Funeshima-Fuji N, et al.
- Organizer
  13^<th> Congress of the European Society For Organ Transplantation
- Place of Presentation
  European Society For Organ Transplantation
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390355
[Presentation] Involvement of PD-1/PD-L1 pathway for induction of suppression to alloantigen by CD4+CD25+ regulatory T cell2006
- Author(s)
  Kitazawa Y, Fujino M, Hara Y, Kimura H, Azuma M, Abe R, Li X-K.
- Organizer
  World Transplant Congress 2006
- Place of Presentation
  Boston
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390355

1. LI X-k. (60321890)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. UEMOTO S. (40252449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. FUJINO M. (50392329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. MATSUNO K. (20094047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KIMURA H. (80115477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 鈴木英年 (70242758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 鈴木盛一 (00111386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. SUZUKI H.

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

FUJI Naoko 藤 直子 (舟島 直子)

FUNESHINA N. 藤 直子

舟島 直子

Research Projects

Research Products

Co-Researchers

ES細胞の制御性樹状細胞への分化誘導および免疫療法の開発に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

樹状細胞を標的とした新規免疫抑制ペプチドの免疫制御機序解明および臓器移植への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of the induction and maintenance of the transplantation tolerance and usage of the Treg cells as a cellular therapy for treatment allograft rejection and GvHD

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

GENE-EXPRESSION PROFILES OF THE PERIPHERAL BLOOD MONONUCLEAR CELLS FROM TOLERANT RAT AND LIVING-DONOR LIVER TRANSPLANT RECIPIENTS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prolongation of rat major histocompatibihty complex-compatible cardiac allograft survival during pregnancy2009

Author(s)

Journal Title

Data Source

[Journal Article] Survival of skin allografts is prolonged in mice with a dominantnegative H-Ras2008

Author(s)

Journal Title

Data Source

[Journal Article] Foxp3-expressing regulatory T-cells expanded with CD28 superagonist antibody prevent rat cardiac allograft rejection2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Involvement of the PD-1/PD-L1 pathway in CD4+CD25+ regulatory T cells activity to suppress alloimmune responses2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] (総説)実験肝移植における免疫寛容の誘導2006

Author(s)

Journal Title

Data Source

[Journal Article] (総説)実験肝移植における免疫寛容の誘導2006

Author(s)

Journal Title

Data Source

[Journal Article] Genetic heterogeneity and efficiency of two different methods of adenovirus-mediated gene transfer in a rat liver transplantation model.2006

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of allogeneic T cell responses by dendritic cells expressing transduced Indoleamine 2,3-Dioxygenase2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood.2005

Author(s)

Journal Title

Data Source

[Journal Article] Potential Regulatory Function of Dendritic Cells Overexpression Indoleamine 2,3-Dioxygenase2005

Author(s)

Journal Title

Data Source

[Journal Article] The enhanced effects of biodegradable microsphere loaded tacrolimus on mice islet allograft and its reduced adverse effects on insulin secretion.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment result in a distinct tolerant state in rat heart transplantation model2004

Author(s)

FUJI Naoko 藤直子 (舟島直子)

FUNESHINA N. 藤直子

舟島直子