HARA Kentaro 原賢太郎

Researcher Number	60400248
Affiliation (based on the past Project Information) *help	2007: Tohoku University, Graduate School of Medicine, COE Fellow 2006: 東北大学, 大学院医学系研究科, COEフェロー 2005: Tohoku University, Graduate School of Medicine, COE Fellow, 大学院・医学系研究科, COEフェロー
Review Section/Research Field	Except Principal Investigator Cell biology / Biological Sciences
Keywords	Except Principal Investigator ノックアウトマウス / β-TrCP2 / ユビキチン / 細胞周期 / Geminin / cell cycle / p27 / affinity chromatography / アフィニティークロマトグラフィー / 分化 … More / 細胞増殖 / ユビキチン化 / 発生・分化 / 発現制御 / GO phase / CDK inhibitor / 蛋白質 / GO期 / CDKインヒビター / circadian rhythm / knockout mouse / F-box protein / Ubiquitin / in situ hybridization / 血管リモデリング / 概日リズム / F-boxタンパク質 / knock-out mouse / ubiquitin ligase / プロテオーム解析 / プロテオーム / 蛍光色素標識 / ユビキチンリガーゼ / セントリンII / 蛍光タンパク質 / histoneH3.1 / レンチウィルス / 蛍光ラベル / 細胞内小器官 / 複製ライセンシング / 転写制御 / ES細胞 / DNA複製 / β-catenin / Tcf-LacZトランスジェニックマウス / たんぱく質 / HDAC / EID / C2C12 / p300 / EID4 / EID2 / 蛍光顕微鏡 / Cdt1 / 前複製複合体 / Mitosis / DNA合成 / 過剰複製 Less

発生におけるタンパク質分解制御機構とその意義の解明
- Principal Investigator
  
  中山啓子
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
The turning point from cell proliferation to cell differentiation
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
細胞周期と初期発生に関わる分子群の新規解析法の開発
- Principal Investigator
  
  中山啓子
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Search for physiological substrates and functional analysis of F-box protein β-TrCP in vivo
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
Analysis of G0 phase-specific large complex including p27
- Principal Investigator
  
  ISHIDA Noriko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University
新規分化抑制因子EIDによる哺乳類幹細胞の未分化性維持機構の解明
- Principal Investigator
  
  中山啓子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Gemininノックアウトマウスを用いた複製開始機構の解析
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Functional Analysis of Proteins regulated by Ubiquitin Ligase
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Tohoku University

All 2009 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration2009
- Author(s)
  Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI
- Journal Title
  
  Lab Invest 89
  
  Pages: 645-656
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19057001
[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007
- Author(s)
  Miyamoto, K., Araki, K.Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C, Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K.I., Harada, M., Motoyama, N., Suda, T. and Hirao, A.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 101-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007
- Author(s)
  Miyamoto, K., Araki, K.Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K.I., Harada, M., Motoyama, N., Suda, T. and Hirao, A.
- Journal Title
  
  Cell Stem Cell 1
  
  Pages: 101-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation2006
- Author(s)
  Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K.I., Fukasawa, K., Schwab, M., Saya, H., Miwa, M.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4020-4029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006
- Author(s)
  Hara, K., et al.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-1293
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-5 signalling pathway2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., lida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biol. 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E.et al.
- Journal Title
  
  Cancer Res. (発表予定)
- Data Source
  KAKENHI-PROJECT-16026202
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006
- Author(s)
  Hara, K. et al.
- Journal Title
  
  Genes Cells, 11
  
  Pages: 1281-93
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E. et al.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4020-4029
- Data Source
  KAKENHI-PROJECT-17045002
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E. et al.
- Journal Title
  
  Cancer Res. (発表予定)
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006
- Author(s)
  Hara, K., et. al.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-11293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006
- Author(s)
  Hara, K. et al.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-1293
- Data Source
  KAKENHI-PROJECT-17045002
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos2006
- Author(s)
  Hara, K., Nakayama, K.I., Nakayama, K.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-1293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Geminin is essential for the development of preimplantation mouseembryos.2006
- Author(s)
  Hara, K., et. al.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-1293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E. et al.
- Journal Title
  
  Cancer Res. (発表予定)
- Data Source
  KAKENHI-PROJECT-17045002
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation2006
- Author(s)
  Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K.I., Fukasawa, K., Schwab, M., Saya, H., Miwa, M.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4020-4029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E., et al.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4020-4029
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E., et. al.
- Journal Title
  
  Cancer Res., 66, , 2006 66
  
  Pages: 4020-4029
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Suppression of centrosome amplification after DNA damage depends of p27 accumulation2006
- Author(s)
  Sugihara, E. et al.
- Journal Title
  
  Cancer Res. 66
  
  Pages: 4020-29
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E., et. al.
- Journal Title
  
  Cancer Res., 66, , 2006 66
  
  Pages: 4020-4029
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Geminin is essential for the development of preimplantation mouse embryos2006
- Author(s)
  Hara, K., Nakayama, K.I., Nakayama, K.
- Journal Title
  
  Genes Cells 11
  
  Pages: 1281-1293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-δsignalling pathway2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., lida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biol. 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Journal Article] Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens.2005
- Author(s)
  Kase, S., Ikeda, H., Harada, T., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Nakayama, K.I., Nakayama, K., Ohno, S., Yoshida, K.
- Journal Title
  
  Curr.Eye Res. 30
  
  Pages: 437-442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Molecular dissection of the interaction between p27 and KPC, the ubiquitinligase that regulates proteolysis of p27 in G1 phase.2005
- Author(s)
  Kotoshiba, S., Kamura, T., Hara, T., Ishida, N., Nakayama, K.I.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 17694-17700
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.2005
- Author(s)
  Kase, S., Nakayama, K.I., Nakayama, K., Ikeda, H., Harada, T., Harada, C., Ohgami, K., Shiratori, K., Ohno, S., Yoshida, K.
- Journal Title
  
  Int.J.Mol.Med. 16
  
  Pages: 257-262
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27^<Kip1> at G1 phase.2004
- Author(s)
  Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I.
- Journal Title
  
  Nat.Cell Biol. 6
  
  Pages: 1229-1235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Involvement of p27KIP1 in the proliferation of the developing corneal endothelium.2004
- Author(s)
  Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ilieva, I.B., Ohno, S., Nishi, S., Nakayama, K.I.
- Journal Title
  
  Invest.Ophthalmol.Vis.Sci. 45
  
  Pages: 2163-2167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment.2004
- Author(s)
  Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nakayama, K.I.
- Journal Title
  
  Graefes Arch.Clin.Exp.Ophthalmol 242
  
  Pages: 437-441
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Journal Article] Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body.2004
- Author(s)
  Yoshida, K., Nakayama, K., Kase, S., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nishi, S., Nakayama, K.I.
- Journal Title
  
  Anat.Embryol 208
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370084
[Presentation] Gemininは着床前初期発生に必須である2007
- Author(s)
  原賢太郎, et. al.
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Gemininは着床前初期発生に必須である,第30回日本生物学会年会2007
- Author(s)
  原賢太郎, et al
- Organizer
  第30回日本物資生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PLANNED-19057001
[Presentation] Gemininは着床前初期発生に必須である,第30回日本分子生物学会年会2007
- Author(s)
  原賢太郎, et. al.
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19044004
[Presentation] Gemininは着床前初期発生に必須である,第30回日本分子生物学会年会2007
- Author(s)
  原賢太郎, et. al.
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19657055
[Presentation] Gemininは着床前初期発生に必須である,第30回日本分子生物学会年会2007
- Author(s)
  原賢太郎, et. al.
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18370075
[Presentation] Suppression of centrosome amplification after DNA damage depends on p27 accumulation2006
- Author(s)
  Sugihara, E., Nakayama, K., Nakayama, K.I., Saya, H. and Miwa, M.
- Organizer
  20trh IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Geminin is essential for development of preimplantation embryos2006
- Author(s)
  Hara, K., Nakayama, K. and Nakayama, K.
- Organizer
  Cold Spring Harbor Symposium"The Cell Cycle"
- Place of Presentation
  Cold Spring Harbor, NY
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Presentation] Geminin is essential for the development of preimplantation mouse embryos.2006
- Author(s)
  Hara, K., et. al.
- Organizer
  The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic,
- Place of Presentation
  Sendai, Japan
- Year and Date
  2006-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Presentation] Geminin is essential for development of preimplantation embryos2006
- Author(s)
  Hara, K.
- Organizer
  Cold Spring Harbor Symposium "The Cell Cycle"
- Place of Presentation
  Cold Spring Harbor, NY
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Presentation] Geminin is essential for development of preimplantation embryos2006
- Author(s)
  Hara, K
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Geminin is essential for development of preimplantation embryos2006
- Author(s)
  Hara, K
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370075
[Presentation] Geminin is essential for the development of preimplantation mouse embryos2006
- Author(s)
  Hara, K., Nakayama, K. and Nakayam, K.
- Organizer
  The 3rd International Symposium on "Novel perspectives in cancer research and translation to the clinic
- Place of Presentation
  Sendai, Japan
- Year and Date
  2006-11-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Geminin is essential for development of preimplantation embryos2006
- Author(s)
  Hara, K.
- Organizer
  Cold Spring Harbor Symposium "The Cell Cycle"
- Place of Presentation
  Cold Spring Harbor, NY
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Geminin is essential for the development of preimplantation mouseembryos.2006
- Author(s)
  Hara, K., et. al.
- Organizer
  The 3rd International Symposium on ゛Novel perspectives in cancer research and translation to the clinic,
- Place of Presentation
  Sendai, Japan
- Year and Date
  2006-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570171
[Presentation] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006
- Author(s)
  Sugihara, E
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370075

1. NAKAYAMA Keiko (60294972)

# of Collaborated Projects: 8 results

# of Collaborated Products: 19 results
2. ISHIDA Noriko (10361073)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. 舟山亮 (20452295)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 山田秀俊 (70511955)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 中谷雅明 (70422095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
6. 中野星児 (00529448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 西田有一郎 (00551821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 三宅智 (00332346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARA Kentaro 原 賢太郎

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[Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration2009

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[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007

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[Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool2007

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[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation2006

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[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006

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[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence through activating ROS/PKC-5 signalling pathway2006

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[Journal Article] Suppression of centrosome amplification after DNA damage depends on p27 accumulation.2006

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[Journal Article] Geminin is essential for the development of preimplantation mouse embryos.2006

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HARA Kentaro 原賢太郎