HONMA Masashi 本間雅

Researcher Number	60401072
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京大学, 医学部附属病院, 講師 2017: 東京大学, 医学部付属病院, 特任准教授 2014 – 2015: 東京大学, 医学部附属病院, 准教授 2014 – 2015: 東京大学, 医学部附属病院, 特任准教授 2007 – 2013: 東京大学, 医学部附属病院, 助教 … More 2011: 東京大学, 医学部・附属病院, 助教 2007: The University of tokyo, Faculty of Medicine, Assistant Professor 2006: 東京大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 47040:Pharmacology-related / Medium-sized Section 50:Oncology and related fields / Medical pharmacy Except Principal Investigator Medical pharmacy / Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Medium-sized Section 57:Oral science and related fields / Medium-sized Section 90:Biomedical engineering and related fields / Functional basic dentistry / Applied pharmacology / Drug development chemistry / Complex systems
Keywords	Principal Investigator シグナル伝達 / 骨代謝 / 生体分子 / 生理活性 / RANKL / 薬理学 / RANKL逆シグナル / 老化 / 骨芽細胞 / 骨粗鬆症 … More / 発現制御 / 炎症 / 自己免疫疾患 / シグナル修飾抗体 / 癌免疫応答 / 免疫学 / 発生分化 / Frizzled / Wnt / 発生・分化 / ナノ材料 / 薬理活性 / 骨吸収 / 骨形成 / 双方向シグナル / 破骨細胞 / 骨・軟骨代謝学 / ClassC Vps complex / 分泌 / Class C Vps complex / Vps33a / リソソーム / トラフィッキング / 生理学 … More Except Principal Investigator 薬剤反応性 / 生体分子 / 薬理学 / RANKL / 骨芽細胞 / 骨代謝 / RANKL結合ペプチド / トランスレーショナルリサーチ / 膜小胞 / 抗体創薬 / 細胞内シグナル / 骨細胞 / 免疫学 / ペプチド創薬 / 骨形成 / ゼラチンハイドロゲル / HLA / 薬剤性肝障害 / 破骨細胞 / 発現制御 / シグナル伝達 / 分子標的薬 / 癌 / Wntシグナル / 生活動作 / 骨リモデリング / 小胞 / 破骨細胞活性化 / ATP / アポトーシス / 骨形成活性 / 人工エクソソーム / 骨形成促進剤開発 / RANK搭載膜小胞 / 抗体改編技術 / AFM / プロテオリポソーム / 原子間力顕微鏡 / プロテオリポソーム技術 / RaPID法 / LassoGraft Technology / RANKL逆シグナル / 骨形成促進薬 / 軟骨細胞 / W9ペプチド / Wペプチド / 軟骨代謝 / 投与量設計 / 治療最適化 / in silico解析 / キナーゼ阻害剤 / 副作用 / がん / 抗がん剤 / システム薬理学 / 機械学習 / 細胞毒性 / RANK-RANKL相互作用 / 細胞内シグナル伝達 / 骨・軟骨代謝 / 細胞分化制御 / 関節リウマチ / RANK / 軟骨形成 / ペプチド / 骨形成促進 / ラベリング法 / 軟骨変性抑制 / 細胞間ネットワーク / transporters / intestinal absorption / responses to drugs / lipids / トランスポーター / 消化管吸収 / 脂質 / リボゾーム化 / 骨形態計測 / RANKL親和性 / 骨形成促進剤 / 低侵襲 / 骨造成 / 粘膜下注射 / 粒子状担体 / 注射による骨造成 / ペプチド修飾 / CHPナノゲル / BMP-2 / 新規骨形成薬 / 肝障害 / 増悪 / 薬物性肝障害 / 特異体質毒性 / シミュレーション / アバカビル / 免疫応答 / プロテオーム / 特異体質性毒性 / 医療・福祉 / 臨床 / 蛋白質 / 療・福祉 / 炎症性サイトカイン / 医薬品化学 / 内因性小分子 / 薬物輸送担体 / 薬物代謝酵素 / 生体反応性 / 情報工学 / 生理学 / 毒性 / 薬物体内動態 / 双方向シグナル / 骨粗鬆症 / 薬物動態 / オフ・ターゲット / キナーゼ Less

Analysis on the relationship between osteoblastic extracellular vesicles and osteoclast activation under daily movement
- Principal Investigator
  
  Kariya Yoshiaki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Development of novel signal modifying molecules based on comprehensive decoding of Wnt signaling
- Principal Investigator
  
  池淵祐樹
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analysis of the roles of RANKL reverse signaling in the autoimmune disease developmentPrincipal Investigator
- Principal Investigator
  
  本間雅
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  The University of Tokyo
Evaluation of anti-cancer potential of a novel RANKL reverse signaling inhibitorPrincipal Investigator
- Principal Investigator
  
  Honma Masashi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  The University of Tokyo
Development of a revolutionary bone anabolic reagent by optimizing the RANKL reverse signaling to stimulate bone formation.
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tokyo Medical and Dental University
Optimization for usage of molecular targeted drugs on cancer therapy
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Analysis on the pharmacological mechanism of W9 peptide and development for the novel drug based on the strong potential for chondrocyte differentiation
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Analyses of crosstalk between RANKL reverse signaling and Wnt signaling pathways in osteoblastsPrincipal Investigator
- Principal Investigator
  
  Honma Masashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Development of in silico prediction method for idiosyncratic adverse reactions associated with HLA genotypes
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of a novel biologic showing downregulation of immune responses, suppression of bone destruction and retention in the target site.Principal Investigator
- Principal Investigator
  
  Honma Masashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
A new drug development for accelerating bone and/or cartilage formation by RANK-like peptide
- Principal Investigator
  
  HASEGAWA Nozomi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Analysis on the spatiotemporal regulation of osteoclasts maturation via the osteocytic apoptosis
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Establishment of the method evaluating the risk for idiosyncratic adverse drug reactions.
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of a bifunctional, anti-resorptive and pro-ostegenic, compoundPrincipal Investigator
- Principal Investigator
  
  Honma Masashi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Analysis on the influence of RANKL reverse signaling in the development of rheumatoid arthritis
- Principal Investigator
  
  Ikebuchi Yuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Development of a new drug candidate to stimulate bone formation by oligomerization of RANKL-binding peptides
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Establishment of systems-based prediction method for drug adverse effects.
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Basis study for the prediction of fatal DILI risk based on MHC expression in the liver
- Principal Investigator
  
  Ito Kousei
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Analysis of physiological roles of RANKL reverse signaling in bone homeostasisPrincipal Investigator
- Principal Investigator
  
  Honma Masashi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Mechanistic analysis of hand-foot syndrome associated with kinase inhibitors
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Development of anti-RANKL antibody without the suppression of bone formationPrincipal Investigator
- Principal Investigator
  
  HONMA Masashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Analyses of small molecules behaviors in the body which is emerged by the cooperation of multi-organs.
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Mechanism analysis of abacavir hypersensitivity
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Evaluation of RANKL reverse signaling as therapeutic targets for osteoporosisPrincipal Investigator
- Principal Investigator
  
  HONMA Masashi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Physiological situation based prediction of the adverse effects associated with molecularly-targeted drugs.
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Feasibility study of RANKL subcellular trafficking as a novel therapeutic target for osteoporosisPrincipal Investigator
- Principal Investigator
  
  HONMA Masashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Investigation on the molecular mechanism of NPC1L1-mediated cholesterol uptake
- Principal Investigator
  
  ITO Kousei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] The potential of RANKL reverse signaling as a novel pharmacological target2023
- Author(s)
  Honma Masashi
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 3 Pages: 253-257
- DOI
  10.1254/fpj.22145
- ISSN
  0015-5691, 1347-8397
- Year and Date
  2023-05-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K19401
[Journal Article] RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target2021
- Author(s)
  Honma Masashi、Ikebuchi Yuki、Suzuki Hiroshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 218 Pages: 107682-107682
- DOI
  10.1016/j.pharmthera.2020.107682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22676, KAKENHI-PROJECT-18H02918
[Journal Article] Mechanisms of RANKL delivery to the osteoclast precursor cell surface2020
- Author(s)
  Honma Masashi、Ikebuchi Yuki、Suzuki Hiroshi
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 39 Issue: 1 Pages: 27-33
- DOI
  10.1007/s00774-020-01157-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22676, KAKENHI-PROJECT-18H02918
[Journal Article] RANKL逆シグナル経路を標的とした新たな創薬の可能性2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 773-777
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] カップリング・シグナル受容分子としてのRANKL2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  THE BONE
  
  Volume: Vol.33 No.1 Pages: 57-61
- Data Source
  KAKENHI-PROJECT-16H05445
[Journal Article] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの関与2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 608-614
- NAID
  40021933906
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] Integrative and theoretical research on the architecture of a biological system and its disorder2019
- Author(s)
  Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue, Yoshihisa Kurachi
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 3 Pages: 443-451
- DOI
  10.1007/s12576-019-00667-8
- NAID
  40021874158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04162, KAKENHI-PROJECT-16KT0194, KAKENHI-PROJECT-18H04062, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-15H04678, KAKENHI-PROJECT-16K00410
[Journal Article] 骨吸収と骨形成のカップリングにおけるRANKL逆シグナルの関与2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: Vol.71 No.6 Pages: 608-614
- NAID
  40021933906
- Data Source
  KAKENHI-PROJECT-16H05445
[Journal Article] カップリング・シグナル受容分子としてのRANKL2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  THE BONE
  
  Volume: 33 Pages: 57-61
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] 逆シグナル経路を標的とした新たな創薬の可能性2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  BIO Clinica
  
  Volume: Vol.34 No.9 Pages: 7-11
- Data Source
  KAKENHI-PROJECT-16H05445
[Journal Article] 骨形成・吸収におけるRANKリガンドシグナルの新たな役割2019
- Author(s)
  池淵祐樹、本間雅、鈴木洋史
- Journal Title
  
  血液内科
  
  Volume: 79 Pages: 100-105
- NAID
  40021979045
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] The clustering-induction of RANKL molecules could stimulate early osteroblast differentiation2019
- Author(s)
  E. Sone, D. Noshiro, Y. Ikebuchi, M. Nakagawa, M. Khan, Y. Tamura, M. Ikeda, M. Oki, R. Murali, T. Fujimori, T. Yoda, M. Honma, H. Suzuki, T. Ando, and K. Aoki
- Journal Title
  
  Biophys. Biochem. Res. Commun.
  
  Volume: 509 Issue: 2 Pages: 435-440
- DOI
  10.1016/j.bbrc.2018.12.093
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26119003, KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-18H02918, KAKENHI-PROJECT-17F17124, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-19H01068
[Journal Article] Roles of RANKL in the bone remodeling process2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  生化学
  
  Volume: 91 Issue: 4 Pages: 529-533
- DOI
  10.14952/SEIKAGAKU.2019.910529
- NAID
  40022022827
- ISSN
  0037-1017
- Year and Date
  2019-08-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16H05445
[Journal Article] RANKL逆シグナルによる骨代謝制御2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Journal Title
  
  生化学
  
  Volume: 91 Pages: 529-532
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] RANKL結合ペプチドによる骨形成促進メカニズムの検討2018
- Author(s)
  曽根絵梨、Masud Khan、能代大輔、池淵祐樹、本間雅、田村幸彦、菅森泰隆、鈴木洋史、宇田川信之、青木和宏
- Journal Title
  
  日本骨形態計測学会雑誌
  
  Volume: 28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02918
[Journal Article] Coupling of bone resorption and formation by RANKL reverse signalling.2018
- Author(s)
  Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H
- Journal Title
  
  Nature
  
  Volume: 561 Issue: 7722 Pages: 195-200
- DOI
  10.1038/s41586-018-0482-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-18H02918, KAKENHI-PROJECT-16H06261, KAKENHI-PROJECT-17F17124, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-16K20419, KAKENHI-PROJECT-18K04734
[Journal Article] RANKL逆シグナルによる骨吸収と骨形成の共役2018
- Author(s)
  本間雅, 池淵祐樹
- Journal Title
  
  First Author's
  
  Volume: - Pages: 095
- DOI
  10.7875/first.author.2018.095
- Open Access
- Data Source
  KAKENHI-PROJECT-16H05445, KAKENHI-PROJECT-18H02918
[Journal Article] Mechanism analyses and mechanism-based prediction for adverse drug reactions using systems pharmacology2016
- Author(s)
  Kariya Y, Honma M, Suzuki H.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 147 Issue: 2 Pages: 89-94
- DOI
  10.1254/fpj.147.89
- NAID
  130005125653
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-24249034
[Journal Article] Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology.2015
- Author(s)
  Takahiro Amemiya, Masashi Honma, Yoshiaki Kariya, Samik Ghosh, Hiroaki Kitano, Yoshihisa Kurachi, Ken-ichi Fujita, Yasutsuna Sasaki, Yukio Homma, Darrel R Abernethy, Haruki Kume, Hiroshi Suzuki.
- Journal Title
  
  npj Systems Biology and Applications
  
  Volume: 1 Issue: 1 Pages: 1-10
- DOI
  10.1038/npjsba.2015.5
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-24249034
[Journal Article] Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts2015
- Author(s)
  Notomi T, Kuno M, Ezura Y, Honma M, Ishizuka T, Ohura K, Yao H and Noda M.
- Journal Title
  
  Bone
  
  Volume: 81 Pages: 306-314
- DOI
  10.1016/j.bone.2015.07.031
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08184, KAKENHI-PROJECT-15K15025, KAKENHI-PROJECT-15K15558, KAKENHI-PUBLICLY-15H01413, KAKENHI-PROJECT-25250001, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-25290002, KAKENHI-PROJECT-26282182
[Journal Article] Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice.2014
- Author(s)
  Naoki Ito, Kousei Ito, Yuki Ikebuchi, Tomoko Kito, Hiroshi Miyata, Yu Toyoda, Tappei Takada, Akihiro Hisaka, Masashi Honma, Akira Oka, Hiroyuki Kusuhara, and Hiroshi Suzuki.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 103(10) Issue: 10 Pages: 3342-8
- DOI
  10.1002/jps.24138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J03163, KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015
[Journal Article] Regulatory mechanisms of RANKL presentation to osteoclast precursors2014
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Journal Title
  
  Current Osteoporosis Reports
  
  Volume: 12(1) Issue: 1 Pages: 115-120
- DOI
  10.1007/s11914-014-0189-0
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24659668, KAKENHI-PROJECT-24890048, KAKENHI-PROJECT-25670632
[Journal Article] Establishment of optimized in vitro assay methods for evaluating osteocyte functions2014
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: in press Issue: 1 Pages: 1-12
- DOI
  10.1007/s00774-013-0555-5
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24890048
[Journal Article] Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies2013
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 34(9) Issue: 9 Pages: 489-507
- DOI
  10.1002/bdd.1865
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136015, KAKENHI-PROJECT-24249034
[Journal Article] Contribution of Protein Binding, Lipid Partitioning, and Asymmetrical Transport to Drug Transfer into Milk in Mouse Versus Human2013
- Author(s)
  Naoki Ito, Kousei Ito, Hiroki Koshimichi, Akihiro Hisaka, Masashi Honma, Takashi Igarashi, Hiroshi Suzuki
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 30(9) Issue: 9 Pages: 2410-2422
- DOI
  10.1007/s11095-013-1085-5
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015
[Journal Article] Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies2013
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 28(9) Issue: 9 Pages: 1936-1949
- DOI
  10.1002/jbmr.1941
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PROJECT-24390349, KAKENHI-PROJECT-24890048, KAKENHI-PLANNED-22136015
[Journal Article] RANKL subcellular trafficking and regulatory mechanisms in osteocytes.2013
- Author(s)
  Honma M, Ikebuchi Y, Kariya Y, Hayashi M, Hayashi N, Aoki S, Suzuki H
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: Epub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390349
[Journal Article] Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders2011
- Author(s)
  Naoko Yamamoto, Masashi Honma and Hiroshi Suzuki
- Journal Title
  
  Molecular Phammacology
  
  Volume: 80 Pages: 466-475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390041
[Journal Article] Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders2011
- Author(s)
  Naoko Yamamoto, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 80 Issue: 3 Pages: 466-475
- DOI
  10.1124/mol.110.070862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390041, KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015
[Journal Article] Analysis and prediction of drug transfer into human milk taking into consideration secretion and reuptake clearances across the mammary epithelia2011
- Author(s)
  Hiroki Koshimichi, Kousei Ito, Akihiro Hisaka, Masashi Honma, Hiroshi Suzuki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 39(12) Issue: 12 Pages: 2370-2380
- DOI
  10.1124/dmd.111.040972
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-22136015
[Journal Article] Hiroshi Suzuki Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells2010
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Akiko Hanamura, Shigeki Aoki, Tadashi Ninomiya, Yuko Nakamichi, Nobuyuki Udagawa
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: Vol.26Issue4 Pages: 689-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791364
[Journal Article] Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis2010
- Author(s)
  Shigeki Aoki, Masashi Honma, Yoshiaki Kariya, Yuko Nakamichi, Tadashi Ninomiya, Naoyuki Takahashi, Nobuyuki Udagawa, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790129
[Journal Article] (*corresponding) Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis.2010
- Author(s)
  Shigeki Aoki, Masashi Honma*, Yoshiaki Kariya, Yuko Nakamichi, Tadashi Ninomiya, Naoyuki Takahashi, Nobuyuki Udagawa, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Research (in press)
- Data Source
  KAKENHI-PROJECT-20790129
[Journal Article] (*corresponding) Vps33a Mediates RANKL Storage in Secretory Lysosomes in Osteoblastic Cells.2009
- Author(s)
  Yoshiaki Kariya, Masashi Honma*, Shigeki Aoki, Atsushi Chiba, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Research Vol.24Issue10
  
  Pages: 1741-52
- Data Source
  KAKENHI-PROJECT-20790129
[Journal Article] Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells2009
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Shigeki Aoki, Atsushi Chiba, Hiroshi Suzuki
- Journal Title
  
  Journal of Bone and Mineral Research Volume 24 Issue 10
  
  Pages: 1741-1752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790129
[Patent] 抗RANKL抗体2015
- Inventor(s)
  本間雅、池淵祐樹、林円香、苅谷嘉顕、鈴木洋史
- Industrial Property Rights Holder
  本間雅、池淵祐樹、林円香、苅谷嘉顕、鈴木洋史
- Industrial Property Rights Type
  特許
- Filing Date
  2015-02-20
- Overseas
- Data Source
  KAKENHI-PROJECT-24390349
[Patent] 抗ＲＡＮＫＬ抗体2014
- Inventor(s)
  本間雅、林円香、池淵祐樹、苅谷嘉顕、鈴木洋史
- Industrial Property Rights Holder
  本間雅、林円香、池淵祐樹、苅谷嘉顕、鈴木洋史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-030349
- Filing Date
  2014-02-20
- Data Source
  KAKENHI-PROJECT-24659668
[Patent] 抗RANKL抗体2014
- Inventor(s)
  本間雅、鈴木洋史、苅谷嘉顕、林円香、池淵祐樹
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-030349
- Filing Date
  2014-02-20
- Data Source
  KAKENHI-PROJECT-24659668
[Patent] 新規骨粗鬆症治療薬2012
- Inventor(s)
  本間雅、鈴木洋史、苅谷嘉顕、林円、青木重樹
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2012-12-04
- Overseas
- Data Source
  KAKENHI-PROJECT-24390349
[Presentation] RANKL分子を標的とした創薬の可能性2022
- Author(s)
  本間雅、中村圭佑、池淵祐樹、苅谷嘉顕、鈴木洋史
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K19401
[Presentation] 石灰化組織評価の実践とネットワーキング　骨形態計測法からシグナル伝達研究への発展.2020
- Author(s)
  青木和広, 池淵祐樹, Masud Khan, 菅森泰隆, 田村幸彦, 本間雅.
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19H01068
[Presentation] RANKL-RANK-OPGシグナル研究の最前線　膜型RANKLを標的にした骨形成促進薬の開発.2020
- Author(s)
  青木和広, 清水優里, Lu Wei, 廣橋優奈, 曽根絵梨, 池淵祐樹, Masud Khan, Fatma Rashed, 田村幸彦, 菅森泰隆, 寺坂尚紘, 宇田川信之, 依田哲也, 本間雅, 菅裕明.
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19H01068
[Presentation] Osteoblastic RANKL as a coupling signal acceptor2019
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Hiroshi Suzuki
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Involvement of RANKL reverse signaling in coupling of bone resorption and formation2019
- Author(s)
  Masashi Honma
- Organizer
  第16回Bone Biology Forum
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Development of a novel biologic agent for treating RA2019
- Author(s)
  Masashi Honma, Remi Kurata, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Organizer
  46th annual meeting of the European Calcified Tissue Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Develoment of a novel biologic agent for treating RA2019
- Author(s)
  Honma M., Kurata R., Ikebuchi Y., Kariya Y., Suzuki H.
- Organizer
  European Calcified Tissue Society Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] RANKL 逆シグナルの生理的役割2019
- Author(s)
  本間雅
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] RANKL逆シグナルによる骨吸収と骨形成の共役2019
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor for vesicular RANK derived from maturing osteoclasts.2018
- Author(s)
  Honma, M.、Ikebuchi, Y.、Kariya, Y.、Suzuki, H.
- Organizer
  AAPS PharmSci 360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 骨吸収と骨形成のカップリングにおけるRANKLの役割2018
- Author(s)
  本間雅, 池淵祐樹, 林円香, 苅谷嘉顕, 鈴木洋史
- Organizer
  日本薬学会第１３８年会
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor recognizing vesicular RANK secreted from osteoclasts2018
- Author(s)
  Masashi Honma
- Organizer
  ASEMV2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor for vesicular RANK derived from maturing osteoclasts2018
- Author(s)
  Masashi Honma, Yuki Ikebuchi, Yoshiaki Kariya, Hiroshi Suzuki
- Organizer
  AAPS PharSci360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] Osteoblastic RANKL acts as an osteogenic signal acceptor recognizing vesicular RANK secreted from osteoclasts2018
- Author(s)
  Honma, M.、Ikebuchi, Y.、Suzuki, H.
- Organizer
  ASEMV 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] Development of a novel chimeric protein construct aiming to improve therapeutic efficacy against rheumatoid arthritis2018
- Author(s)
  Kurata, R.、Honma, M.、Ikebuchi, Y.、Kariya, Y.、Suzuki, H.
- Organizer
  AAPS PharmSci 360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] A stimulatory mechanism of RANKL-binding peptide on osteoblast differentiation2018
- Author(s)
  Sone, E.、Noshiro, D.、Ikebuchi, Y.、Khan, M.、Sugamori, Y.、Tamura, Y.、Yoda, T.、Honma, M.、Aoki, K.
- Organizer
  32nd IADR Southeast Asian Division Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 骨芽細胞に発現するRANKLはカップリング・シグナルを受容する2018
- Author(s)
  池淵祐樹、本間雅、苅谷嘉顕、鈴木洋史
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] 関節リウマチに対する新規バイオロジクスの創製検討2018
- Author(s)
  藏田玲美, 本間雅, 池淵祐樹, 苅谷嘉顕, 鈴木洋史
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16K15654
[Presentation] 骨芽細胞に発現するRANKLはカップリング・シグナルを受容する2018
- Author(s)
  池淵祐樹、本間雅、苅谷嘉明、鈴木洋史
- Organizer
  第40回　生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] 骨吸収と骨形成のカップリングにおける RANKL の役割2018
- Author(s)
  本間雅、池淵祐樹、鈴木洋史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-26713045
[Presentation] 関節リウマチに関する新規バイオロジクスの創製検討2018
- Author(s)
  藏田玲美、本間雅、池淵祐樹、苅谷嘉明、鈴木洋史
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18H02918
[Presentation] Analysis of interactions between HLA proteins and drug molecules which lead to the development of idiosyncratic adverse reactions2017
- Author(s)
  Nishiki Nagaya, Masashi Honma, Yoshiaki Kariya, Tomoki Kato, Yuki Ikebuchi, Hiroshi Suzuki
- Organizer
  6th FIP Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15156
[Presentation] カップリング機構におけるRANKLの役割2017
- Author(s)
  本間雅, 池淵祐樹, 林円香, 青木和宏, 苅谷嘉顕, 鈴木洋史
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05445
[Presentation] カップリング機構におけるRANKLの役割2017
- Author(s)
  本間雅、池淵祐樹、林円香、青木和宏、苅谷嘉顕、鈴木洋史
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-26713045
[Presentation] 特異体質性副作用発現に関与するHLAタンパク質-薬物分子の相互作用の解析2016
- Author(s)
  長屋仁織、本間雅、苅谷嘉顕、加藤智起、池淵祐樹、鈴木洋史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26670074
[Presentation] 細胞内シグナルネットワークを考慮したシステム薬理学的心毒性予測2016
- Author(s)
  苅谷嘉顕、本間雅、鈴木洋史
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] 特異体質性薬物副作用の解析2016
- Author(s)
  本間雅、長屋仁織、苅谷嘉顕、池淵祐樹、鈴木洋史
- Organizer
  東京大学医学部附属病院先端医療シーズ開発フォーラム2016
- Place of Presentation
  東京
- Year and Date
  2016-02-02
- Data Source
  KAKENHI-PROJECT-26670074
[Presentation] 薬物副作用に関するトランスレーショナル研究サイクル2015
- Author(s)
  本間雅
- Organizer
  日本薬物動態学会第３０年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] 骨芽細胞におけるRANKL逆シグナルの役割（学会シンポジウム6_骨代謝カップリング機構の新展開3）2015
- Author(s)
  本間　雅、林　円香、池淵祐樹、青木重樹、菅森泰隆、青木和広、鈴木洋史．
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25293377
[Presentation] 骨芽細胞におけるRANKL逆シグナルの役割2015
- Author(s)
  本間雅、林円香、池淵祐樹、青木重樹、菅森泰隆、青木和広、鈴木洋史
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-26670656
[Presentation] Prediction of tki associated cardiotoxicity based on network analyses of intracellular signaling pathways2015
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Organizer
  Workshop on Pharmacological Mechanism-Based Drug Safety Prediction
- Place of Presentation
  Silver Spring, MD, USA
- Year and Date
  2015-08-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] 骨芽細胞におけるRANKL逆シグナルの役割2015
- Author(s)
  本間雅、林円香、池淵祐樹、青木重樹、菅森泰隆、青木和広、鈴木洋史
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-24390349
[Presentation] 薬物副作用に関するトランスレーショナル研究サイクル2015
- Author(s)
  本間雅
- Organizer
  日本薬物動態学会第３０年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-26670074
[Presentation] Systems-based understanding of TKI cardiotoxicity2013
- Author(s)
  Masashi Honma
- Organizer
  第28回日本薬物動態学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] Establishment of a novel method to assess risks of DILI development2012
- Author(s)
  Takaaki Ishida, Yuki Ikebuchi, Masashi Honma, Kousei Ito, Hiroshi Suzuki
- Organizer
  第27回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] キナーゼ阻害薬による副作用発現機構の解析2012
- Author(s)
  本間雅
- Organizer
  日本薬物動態学会　第２７回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] 患者の疾患背景に基づいた薬物誘発性肝障害の発症リスク評価2012
- Author(s)
  池淵祐樹、伊藤晃成、本間雅、山本武人、鈴木洋史
- Organizer
  第12回東京大学生命科学シンポジウム
- Place of Presentation
  東京(東京大学）
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] キナーゼ阻害薬による副作用発現機構の解析2012
- Author(s)
  本間雅
- Organizer
  日本薬物動態学会　第27回年会
- Place of Presentation
  東京
- Year and Date
  2012-11-20
- Invited
- Data Source
  KAKENHI-PLANNED-22136015
[Presentation] 医療現場における薬剤性肝障害発症予測バイオマーカーの探索:育薬・創薬への還元を目指して2012
- Author(s)
  伊藤晃成、本間雅、鈴木洋史
- Organizer
  第20回クリニカルファーマシーシンポジウム・医療薬学フォーラム2012
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Predicting High-Risk Patients for the Onset of Drug-Induced Liver Injury2012
- Author(s)
  Takaaki Ishida, Yuki Ikebuchi, Masashi Honma, Kousei Ito, Hiroshi Suzuki
- Organizer
  日本薬物動態学会第27回年会
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] RANKL細胞内トラフィックの新規治療標的としての可能性2011
- Author(s)
  本間雅
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] RANKL骨芽細胞内挙動とRANKL逆シグナル2011
- Author(s)
  本間雅
- Organizer
  第14回骨発生・再生研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] RANKL細胞内トラフィックを制御する分子基盤2011
- Author(s)
  本間雅
- Organizer
  第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会・合同大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] RANKL reverse signaling triggers RANKL translocation via mTORC2 activation2011
- Author(s)
  Masashi Honma, Akiko Hanamura, Shigeki Aoki, Yoshiaki Kariya, Hiroshi Suzuki
- Organizer
  3rd Joint Meeting of the European Calcified Tissue Society & the International Bone and Mineral Society
- Place of Presentation
  Athens, Greece
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] RANKL骨芽細胞内挙動とRANKL逆シグナル2011
- Author(s)
  本間雅
- Organizer
  第14回骨発生・再生研究会
- Place of Presentation
  東京
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] RANKL reverse signaling triggers RANKL translocation via mTORC2 activation2011
- Author(s)
  Masashi Honma, Akiko Hanamura, Shigeki Aoki, Yoshiaki Kariya and Hiroshi Suzuki
- Organizer
  3rd Joint Meeting of the European Calcified Tissue Society & the International Bone and Mineral Society Athens
- Place of Presentation
  Greece
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] OPGの生理作用発現における、RANKL細胞内挙動制御の重要性2010
- Author(s)
  青木重樹、本間雅、苅谷嘉顕、鈴木洋史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] RANKL細胞内トラフィックの生理的意義2010
- Author(s)
  本間雅
- Organizer
  第28回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-22791364
[Presentation] キナーゼ阻害薬による副作用とオフ・ターゲット阻害プロファイル2010
- Author(s)
  本間雅,山本奈央子,雨宮貴洋,鈴木洋史
- Organizer
  第3回日本ファーマコメトリクス研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390041
[Presentation] チロシンキナーゼ阻害薬の副作用発現における、オフターゲット阻害の重要性2010
- Author(s)
  山本奈央子,本間雅,鈴木洋史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21390041
[Presentation] OPGはRANKLの骨芽細胞内選別輸送を担う2009
- Author(s)
  青木重樹, 本間雅, 苅谷嘉顕, 鈴木洋史
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] OPG functions as a traffic regulator for RANKL.2009
- Author(s)
  Masashi Honma, Shigeki Aoki, Yoshiaki Kariya, Hiroshi Suzuki
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] キナーゼ阻害薬による副作用発現メカニズムの解析2009
- Author(s)
  本間雅,山本奈央子,雨宮貴洋,鈴木洋史
- Organizer
  第3回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21390041
[Presentation] RANKL secretion from secretory lysosomes in osteoblastic cells - the involvement of small GTPase2009
- Author(s)
  Yoshiaki Kariya, Masashi Honma, Hiroshi Suzuki
- Organizer
  Rab27a/b 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society Sydney
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis2009
- Author(s)
  青木重樹, 本間雅, 苅谷嘉顕, 鈴木洋
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] RANKL storage in secretory lysosomes in osteoblastic cells - the involvement of Vps32009
- Author(s)
  Masashi Honma, Yoshiaki Kariya and Hiroshi Suzuki
- Organizer
  International Bone & Mineral Society and Australian & New Zealand Bone & Mineral Society 2nd Joint Meeting
- Place of Presentation
  Sydney
- Year and Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] OPGはRANKLの骨芽細胞内選別輸送を担う2009
- Author(s)
  青木重樹、本間雅、苅谷嘉顕、鈴木洋史
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis2009
- Author(s)
  青木重樹、本間雅、苅谷嘉顕、鈴木洋史
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] EGFRキナーゼ阻害薬による皮膚毒性発現メカニズムの解析2009
- Author(s)
  山本奈央子,本間雅,鈴木洋史
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390041
[Presentation] RANKL storage in secretory lysosomes in osteoblastic cells - the involvement of Vps33a2009
- Author(s)
  Masashi Honma, Yoshiaki Kariya, Hiroshi Suzuki
- Organizer
  2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society Sydney
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] RANKL secretion from secretory lysosomes in osteoblastic cells - the involvement of Rab27a/b2008
- Author(s)
  Yoshiaki Kariya, Masashi Honma and Hiroshi Suzuki
- Organizer
  International Bone & Mineral Society and Australian & New Zealand Bone & Mineral Society 2nd Joint Meeting
- Place of Presentation
  Sydney
- Year and Date
  2008-03-23
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] 骨芽細胞におけるRANKL細胞内動態を制御する因子の解析2008
- Author(s)
  本間雅、苅谷嘉顕、青木重樹、鈴木洋史
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20790129
[Presentation] Cholesterol lowering effect of ezetimibe in UDP-glucuronosyl transferase (UGT) 1A deficient (Gunn) rats2006
- Author(s)
  Takehito Yamamoto, Kousei Ito, Masashi Honma, Tappei Takada, Hiroshi Suzuki
- Organizer
  21st JSSX annual meeting
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390047
[Presentation] Regulatory mechanisms of RANKL presentation to osteoclast precursors
- Author(s)
  Masashi Honma
- Organizer
  11th Meeting of Bone Biology Forum
- Place of Presentation
  Shizuoka
- Year and Date
  2014-08-22 – 2014-08-23
- Invited
- Data Source
  KAKENHI-PROJECT-24390349
[Presentation] RANKL結合ペプチドはマウス頭蓋骨欠損モデルの骨新生を促進する．
- Author(s)
  菅森泰隆、本間雅、加藤玄樹、田村幸彦、古屋優里子、保田尚孝、田畑泰彦、宇田川信之、大谷啓一、鈴木洋史、青木和広
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場（大阪市）
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-25293377
[Presentation] 医薬品適正使用から医薬品創成へ:分子標的薬を例として
- Author(s)
  本間雅
- Organizer
  医療薬学フォーラム2014/第22回クリニカルファーマシーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-06-28 – 2014-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24249034
[Presentation] 医薬品適正使用から医薬品創成へ:分子標的薬を例として
- Author(s)
  本間雅
- Organizer
  医療薬学フォーラム2014/第22回クリニカルファーマシーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-06-28 – 2014-06-29
- Invited
- Data Source
  KAKENHI-PLANNED-22136015
[Presentation] RANKL-binding peptides increased bone formation in a murine calvarial defect model.
- Author(s)
  Y, Sugamori. M, Honma. G, Kato. Y, Tamura. Y, Furuya. H, Yasuda. Y, Tabata. N, Udagawa. K, Ohya. H, Suzuki. K, Aoki.
- Organizer
  アメリカ骨代謝学会2014
- Place of Presentation
  テキサス州ヒューストン市(USA)
- Year and Date
  2014-09-12 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-25293377
[Presentation] 細胞内シグナルネットワークを考慮したシステム薬理学的心毒性予測
- Author(s)
  苅谷嘉顕、本間雅、鈴木洋史
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Invited
- Data Source
  KAKENHI-PLANNED-22136015

1. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 12 results

# of Collaborated Products: 35 results
2. IKEBUCHI Yuki (20645725)

# of Collaborated Projects: 8 results

# of Collaborated Products: 19 results
3. TAKADA Tappei (90376468)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. ITO Kousei (30323405)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
5. AOKI Kazuhiro (40272603)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. Kariya Yoshiaki (20633168)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. HISAKA Akihiro (80420206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. UDAGAWA Nobuyuki (70245801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. MIURA Shougo (90529182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIYAGAWA Kiyoshi (40200133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Takehito (00376469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SEKINE Shuichi (70401007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YOSHIOKA Yasuo (00392308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HASEGAWA Nozomi (50770228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAHASHI Mariko (90334440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KAMATA Haruhiko (00324509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石川拓司 (20313728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田村幸彦 (40188446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 林智広 (30401574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 秋吉一成 (90201285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOSHINARI Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MAEDA Chizuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BHUYAN Md Zahirul Haque

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NOUTOMI Takuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 北野宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 倉智嘉久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 久野みゆき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 安藤敏夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HONMA Masashi 本間 雅

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Analysis of the roles of RANKL reverse signaling in the autoimmune disease developmentPrincipal Investigator

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Evaluation of anti-cancer potential of a novel RANKL reverse signaling inhibitorPrincipal Investigator

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Analyses of crosstalk between RANKL reverse signaling and Wnt signaling pathways in osteoblastsPrincipal Investigator

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Development of a novel biologic showing downregulation of immune responses, suppression of bone destruction and retention in the target site.Principal Investigator

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Development of a bifunctional, anti-resorptive and pro-ostegenic, compoundPrincipal Investigator

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HONMA Masashi 本間雅