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KORENAGA Keiko  是永 圭子

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是永 圭子  コレナガ ケイコ

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Researcher Number 60420535
Affiliation (based on the past Project Information) *help 2012: 国府台病院, 消化器・肝臓内科, 医師
2011: 川崎医科大学, 肝胆膵内科学, 講師
2010: 川崎医科大学, 医学部, 講師
2007 – 2008: 山口大学, 医学部附属病院, 助教
Review Section/Research Field
Except Principal Investigator
Gastroenterology
Keywords
Except Principal Investigator
酸化ストレス / 肝発癌 / 鉄過剰状態 / ミトコンドリア / PolyIC / Hepcidin / C型慢性肝炎 / IFN / MAVS / 鉄過剩状態 / HCVTgM / 小胞体ストレス
  • Research Projects

    (2 results)
  • Research Products

    (58 results)
  • Co-Researchers

    (2 People)
  •  Association of between HCV induced mitochondria dysfunction and viral response by interferon in hepatic iron overloaded

    • Principal Investigator
      KORENAGA Masaaki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Research Institute, International Medical Center of Japan
      Kawasaki Medical School
  •  The role of hepatic mitochondrial function in carcinogenesis of chronic hepatitis C

    • Principal Investigator
      KORENAGA Masaaki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Yamaguchi University

All 2013 2012 2011 2010 2008 2007

All Journal Article Presentation Book

  • [Book] 肥満・脂肪肝の栄養管理を向上させる工夫―体組成計・間接熱量計・フリーラジカル測定器を用いた試みー 酸化ストレスと肝疾患<第8巻>2012

    • Author(s)
      是永匡紹、是永圭子、鈴木淑子、寺本房子、仁科惣治、日野啓輔 坪内博仁編集
    • Publisher
      株式会社嵯峨野
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Book] 型慢性肝疾患の鉄代謝異常に対するBCAA顆粒投与の有効性, 酸化ストレスと肝疾患<第8巻>2012

    • Author(s)
      是永匡紹、仁科惣治、富山恭行、田中志保、是永圭子、溝上雅史、日野啓輔 坪内博仁編集
    • Publisher
      株式会社嵯峨野
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Book] 過剰鉄とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス増殖を抑制する 酸化ストレスと肝疾患 第7巻2011

    • Author(s)
      是永匡紹,池田正徳,加藤宣之,日野啓輔
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Book] 酸化ストレスと肝疾患第4巻C型肝炎ウイルスが惹起する肝脂肪化と酸化ストレス2008

    • Author(s)
      是永 匡紹
    • Total Pages
      197
    • Publisher
      メディカルジャーナル社
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Book] 酸化ストレスと肝疾患第4巻, C型肝炎ウイルスが惹起する肝脂肪化と酸化ストレス2008

    • Author(s)
      是永匡紹
    • Publisher
      メディカルジャーナル社
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Clinical usefulness of non-protein respiratory quotient measurement in non-alcoholic fatty liver disease2013

    • Author(s)
      Korenaga K, Korenaga M, et al.
    • Journal Title

      Hepatol Res

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] Ex vivo induction of IFN-λ3 by a TLR7 agonist determines response to Peg-IFN/Ribavirin therapy in chronic hepatitis C patients.2013

    • Author(s)
      Murata K, Korenaga M, et al.
    • Journal Title

      J Gastroenterol

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] 肝硬変に対する治療.2012

    • Author(s)
      是永匡紹, 溝上雅史
    • Journal Title

      最新 C型肝炎 治療薬の使い方 (芥田憲夫, 斉藤聡, 角田圭雄編集, 診断と治療社, 東京)

      Pages: 46-54

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] C型肝炎の肝発癌と発癌抑制(インターフェロン少量/ウルソ/SNMC/BCAAなど).2012

    • Author(s)
      是永匡紹, 溝上雅史
    • Journal Title

      肝炎ウイルス-B型・C型 インフォームドコンセントのための図説シリーズ (熊田博光編集, 医薬ジャーナル社, 大阪)

      Pages: 100-105

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] 症例13 メトホルミンと瀉血が有効だった症例.2012

    • Author(s)
      是永匡紹, 是永圭子, 日野啓輔, 溝上雅史
    • Journal Title

      症例に学ぶNASH/NAFLDの診断と治療―臨床で役立つ症例 (岡上武, 米田正人, 江口有一郎, 角田圭雄, 中島淳編集, 診断と治療社, 東京)

      Volume: 32

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] HCV感染における鉄過剰異常、酸化ストレスと分岐鎖アミノ酸2012

    • Author(s)
      是永匡紹、日野啓輔, 溝上雅史
    • Journal Title

      肝がん・肝硬変に対する栄養療法の新時代 (市田隆文、平野 克治監・編集, アークメディア 東京)

      Pages: 16-19

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] LecT-Hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients.2012

    • Author(s)
      Ito K, Korenaga M, Mizokami M, 他17名
    • Journal Title

      Hepatology

      Volume: 56 Pages: 1448-56

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.2012

    • Author(s)
      Sawai H, Korenaga M, Mizokami M, 他32名
    • Journal Title

      BMC Med Genet

      Volume: 19;13 Pages: 47-47

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean2012

    • Author(s)
      Nishida N, Korenaga M, Mizokami M, 他33名
    • Journal Title

      PLoS One

      Volume: 7(6)

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice2011

    • Author(s)
      Korenaga M, et al
    • Journal Title

      Liver Int

      Volume: 31 Pages: 552-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice.2011

    • Author(s)
      Korenaga M, Hidaka I, Hino K, 他7名
    • Journal Title

      Liver Int

      Volume: 31(4) Pages: 552-60

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] 過剰鉄とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス増殖を抑制する2011

    • Author(s)
      是永匡紹, 他
    • Journal Title

      酸化ストレスと肝疾患

      Volume: 7 Pages: 41-46

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice2010

    • Author(s)
      Nishina S, Korenaga M, et al
    • Journal Title

      Liver Int.

      Volume: 30 Pages: 683-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] Hepatitis C virus protein and iron overload induce hepatic steatosis through the unfolded protein response in mice2010

    • Author(s)
      Nishina S, Korenaga M, Hino K, 他6名
    • Journal Title

      Liver Int

      Volume: 30(5) Pages: 683-92

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] C型慢性肝炎のpeg-IFN/RBV療法無効例の対策】pegIFN/RBV療法無効例への工夫再燃・null例への再治療の試み2010

    • Author(s)
      是永匡紹, 他
    • Journal Title

      消化器内科

      Volume: 50 Pages: 595-600

    • Data Source
      KAKENHI-PROJECT-22590750
  • [Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription2008

    • Author(s)
      Nishina S, Hino K, Korenaga M, 他9名
    • Journal Title

      Gastroenterology 34(1)

      Pages: 226-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis2008

    • Author(s)
      Korenaga K, Korenaga M, Uchida K, 他5名
    • Journal Title

      Hepatol Res 38

      Pages: 1087-1097

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis.2008

    • Author(s)
      Korenaga K, Korenaga M
    • Journal Title

      Hepatology Research 38(11)

      Pages: 1087-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication.2008

    • Author(s)
      Ando M, Korenaga M, et al
    • Journal Title

      Liver International 28(8)

      Pages: 1156-1166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication Liver Int2008

    • Author(s)
      Ando M, Korenaga M, Hino K, 他8名
    • Journal Title

      28(8)

      Pages: 1158-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] The effect of supplementation with branched-chain amino acids in patients with liver cirrhosis2007

    • Author(s)
      Urata Y, Okita K, Korenaga K, 他5名
    • Journal Title

      37(7)

      Pages: 510-6

    • Data Source
      KAKENHI-PROJECT-19590769
  • [Journal Article] Stronger Neo-Minophagen C^<TM>, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein2007

    • Author(s)
      Hidaka I, Hino K, Korenaga M, 他5名
    • Journal Title

      Liver Int 27

      Pages: 845-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Anti-interferon-α neutralizing antibodies interact with viral responses to interferon in patients with hepatitis C virus infection bearing interferon sensitive IL28B single nucleotide polymorphisms.2012

    • Author(s)
      Korenaga M, Korenaga K, Nishina S, Yoshioka N, Tomiyama Y, Hara Y, Sugiyama M, Nishida N, Murata K, Masaki N, Mizokami M, Hino K.
    • Organizer
      The 63rd annual meeting of the American association for the study of liver diseases (AASLD)
    • Place of Presentation
      Boston, U.S.
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] IFN 少量長期投与はHCV 関連肝発癌における鉄代謝異常を改善する ワークショップ10 肝細胞癌の発症と再発予防を目指した慢性肝炎の治療2012

    • Author(s)
      是永匡紹、仁科惣治、是永圭子、日野啓輔
    • Organizer
      第48回日本肝臓総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] HCVトランスジェニックマウスを用いた分枝鎖アミノ酸・インターフェロンの鉄代謝機構の解析2012

    • Author(s)
      是永匡紹, 他
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Supplementation with branched-chain amino acids improves HCV-induced iron metabolic disorder via upregulation of antioxidant potential by restoring mitochondrial complex I function in iron overloaded transgenic mice expressing HCV polyprotein2012

    • Author(s)
      Korenaga M, et al.
    • Organizer
      64 the AASLD (アメリカ肝臓学会)
    • Place of Presentation
      Boston USA
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Supplementation with branched-chain amino acids improves HCV-induced iron metabolic disorder via upregulation of antioxidant potential by restoring mitochondrial complex I function in iron overloaded transgenic mice expressing HCV polyprotein2012

    • Author(s)
      Korenaga M, Nishina S, Korenaga K, Tomiyama Y, Hara Y, Sakai Y, Shimonaka Y, Mizokami M, Hino K
    • Organizer
      The 63rd annual meeting of the American association for the study of liver diseases (AASLD)
    • Place of Presentation
      Boston, U.S.
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Amino acid Imbalance を有した高齢C型慢性肝疾患への有効性2012

    • Author(s)
      是永匡紹, 他
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] The supplementation with branched-chain amino acids (BCAAS) reduces hepatic iron accumulation and oxidative stress in both transgenic mice and patients with HCV2012

    • Author(s)
      Korenaga M, et al.
    • Organizer
      14th International Symposium on Viral Hepatitis and liver Disease
    • Place of Presentation
      上海
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] BTRを指標としたC型慢性肝疾患への治療介入2012

    • Author(s)
      是永匡紹, 他
    • Organizer
      第39回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] IFN少量長期投与はHCVが誘導する鉄代謝異常を改善し肝発癌を抑制する2012

    • Author(s)
      是永匡紹, 他
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Oral branched-chain amino acid supplementation reduces oxidative stress and interacts with iron metabolism in patients with hepatitis C virus-related advanced liver fibrosis -a pilot study-.2011

    • Author(s)
      Korenaga M, Korenaga K, Nishina S, Tomiyama Y, Hino K
    • Organizer
      The 62rd annual meeting of the American association for the study of liver diseases (AASLD)
    • Place of Presentation
      San Francisco, U.S.
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Dietary supplementation with branched-chain amino acids reduces hepatic iron accumulation induced by hepatitis C virus proteins and iron overload in mice.2011

    • Author(s)
      Korenaga M, Korenaga K, Nishina S, Tomiyama Y, Hino K
    • Organizer
      The 62rd annual meeting of the American association for the study of liver diseases (AASLD)
    • Place of Presentation
      San Francisco, U.S.
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] 肝炎・肝硬変と鉄に関する最近の話題2011

    • Author(s)
      是永匡紹
    • Organizer
      第15回日本肝臓学会大会(ランチョンセミナー6)
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] BCAA顆粒はHCVTgMにおける肝内鉄過剰と酸化ストレスを抑制する2011

    • Author(s)
      是永匡紹, 仁科惣治, 田中志保, 是永圭子, 日野啓輔
    • Organizer
      第47回 日本肝臓学会総会 ワークショップ1「代謝・酸化ストレスの場としての肝臓」
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] C型慢性肝疾患の鉄代謝異常に対するBCAA顆粒投与の有効性2011

    • Author(s)
      是永匡紹 是永圭子 日野啓輔
    • Organizer
      第15回日本肝臓学会大会 第53回日本消化器病学会大会 シンポジウム14 代謝性・遺伝性肝疾患研究の進歩
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] C型慢性肝疾患に対するBCAA顆粒投与と鉄代謝2011

    • Author(s)
      是永匡紹
    • Organizer
      第47回日本肝臓学会総会(モーニングセミナー)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] テーラーメード医療時代のおける抗IFNα抗体測定の意義2011

    • Author(s)
      是永匡紹 是永圭子 日野啓輔
    • Organizer
      第39回日本肝臓学会西部会 シンポジウム1テーラーメード医療時代のC型肝炎治療戦略
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] C型慢性肝疾患の鉄代謝異常に対するBCAA顆粒投与の有効性2011

    • Author(s)
      是永匡紹, 他
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] BCAA顆粒はHCVTgMにおける肝内鉄過剰と酸化ストレスを抑制する2011

    • Author(s)
      是永匡紹, 他
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Dietary supplementation with branched-chain amino acids reduces hepatic iron accumulation induced by hepatitis C virus proteins and iron overload in mice2011

    • Author(s)
      Korenaga M, et al
    • Organizer
      62 the AASLD(アメリカ肝臓学会)
    • Place of Presentation
      San Francisco USA
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] 鉄負荷HCVTgMにおけるhepcidin25発現とサイトカインの網羅的解析2011

    • Author(s)
      是永匡紹, 田中志保, 佐々木雄亮, 下中靖, 日野啓輔
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Iron Induced Oxidative Stress Inhibits Viral Replication in Full Genomic Hepatitis C Virus Replicon Cells2010

    • Author(s)
      Korenaga M, 他
    • Organizer
      61 the AASLD(アメリカ肝臓学会)
    • Place of Presentation
      Boston USA
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] 肝内鉄過剰とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス(HCV)増殖を抑制する2010

    • Author(s)
      是永匡紹, 池田正徳, 日野啓輔
    • Organizer
      第14回日本肝臓学会大会 第52回日本消化器病学会大会 パネルディスカッション7 代謝異常(金属代謝を含む)からみたC型肝炎の病態解析
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] 肝内鉄過剰とミトコンドリア障害が誘導する酸化ストレスはC型肝炎ウイルス(HCV)増殖を抑制する2010

    • Author(s)
      是永匡紹, 他
    • Organizer
      第52回日本消化器病学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590750
  • [Presentation] Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein2008

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第59回AASLD(TheAmerican Association for the Study of Liver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein2008

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第59回AASLD(The American Association for the Study ofLiver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Mitochondrial electron transport inhibition in full genomic hepatitis C virus replicon cells is restored by reducing viral replication2008

    • Author(s)
      Korenaga M, et al
    • Organizer
      第59回AASLD(The American Association for the Study of Liver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Analysis of gene expression related to the lipid and glucose metabolism in iron-overloded transgenic mice expressing the hepatitis C virus polyprotein2008

    • Author(s)
      Korenaga M, et al
    • Organizer
      第59回AASLD(The American Association for the Study of Liver Disease)
    • Place of Presentation
      San Francisco CA USA
    • Year and Date
      2008-11-01
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Cosupplementation with vitamin E and coenzyme Q(10) reduces iron-overloaded induced hepatic steatosisin transgenic mice expressing the hepatitis c virus polyprotein2007

    • Author(s)
      Korenaga M et.al.
    • Organizer
      第58回AASLD(The American Association for the Study of Liver Disease)
    • Place of Presentation
      Boston MA USA
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Inhibition of viral replication prevents HCV-induced mitochondrial respiratory dysfunction in a genome-length replicon system2007

    • Author(s)
      Korenaga M et.al.
    • Organizer
      APDW(Asian Pacific Digestive Week)
    • Place of Presentation
      Kobe Japan
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Cosupplementation with Vitamin E and Coenzyme Q(10)reduces iron-overloaded induced hepatic steatosis in transgenic mice expressing the hepatitis C virus polyprotein2007

    • Author(s)
      Korenaga M, et. al.
    • Organizer
      第58回AASLD(The American Association for the Study of Liver Disease)
    • Place of Presentation
      Boston MA USA
    • Year and Date
      2007-10-27
    • Data Source
      KAKENHI-PROJECT-19590769
  • [Presentation] Inhibition of viral replication prevents HCV-induced Mitochondrial respiratory dysfunction in a genome-length replicon system2007

    • Author(s)
      Korenaga M, et. al.
    • Organizer
      APDW2007(Asian Pacific Digestive Week2007)
    • Place of Presentation
      Kobe Japan
    • Year and Date
      2007-10-18
    • Data Source
      KAKENHI-PROJECT-19590769
  • 1.  KORENAGA Masaaki (70420536)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 58 results
  • 2.  HINO Keisuke (80228741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 20 results

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