HAGIHARA Keisuke 萩原圭祐

Researcher Number	60423183
Other IDs
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 大学院医学系研究科, 特任教授(常勤) 2017 – 2021: 大阪大学, 医学系研究科, 特任教授(常勤) 2016: 大阪大学, 医学系研究科, 寄附講座准教授 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 2012 – 2014: 大阪大学, 医学(系)研究科(研究院), 准教授 2013: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 2011: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Anesthesiology / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator サルコペニア / 牛車腎気丸 / 腸内細菌叢 / メタゲノム / ドラッグリポジショニング / iPS細胞 / 国際情報交換 / ＰＤＥ５阻害薬 / エンドセリン受容体拮抗薬 / サイトカイン / レイノー症状 / 肺高血圧症 … More Except Principal Investigator … More 代謝 / サルコペニア / 抗サルコペニア / 腸内細菌 / 薬物代謝 / 漢方薬 / 脳内鎮痛メカニズム / 脳機能画像 / 漢方薬（牛車腎気丸） / マクロファージ / 脳MRI / 脳の可塑性変化 / 絞扼性神経損傷モデル / 坐骨神経部分損傷モデル / NAA / MRS / MRI / 神経障害性疼痛 / 慢性疼痛 / 牛車腎気丸 / 腸管免疫 / 漢方 / 大建中湯 Less

Analysis of active components in the anti-sarcopenia effect of Goshajinkigan and the bacterial flora contributing to its metabolism
- Principal Investigator
  
  原田和生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Investigation of the gut flora in the treatment with Gosha-jinki-Gan using metagenomics.Principal Investigator
- Principal Investigator
  
  Hagihara Keisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka University
Elucidation of the analgesic mechanism of Japanese herbal medicine resulting from changes in brain plasticity
- Principal Investigator
  
  Nakanishi Miho
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Shiga University of Medical Science
Development of a novel anti-sarcopenia agent using drug re-positioning method with iPS cellsPrincipal Investigator
- Principal Investigator
  
  Hagihara Keisuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Osaka University
腸炎モデルマウスを用いた大建中湯の腸管免疫系への影響についての検討
- Principal Investigator
  
  有光潤介
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Osaka University
Analysis of pathology of the pulmonary hypertension with connective tissue disease using cytokine arrayPrincipal Investigator
- Principal Investigator
  
  HAGIHARA Keisuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University

All 2022 2021 2020 2018 2017 2015 Other

All Journal Article Presentation Book Patent

[Book] 漢方がみちびく心と体のレジリエンス（回復力）2021
- Author(s)
  萩原圭祐
- Total Pages
  244
- Publisher
  大阪大学出版会
- ISBN
  4872596420
- Data Source
  KAKENHI-PROJECT-19K07937
[Journal Article] Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V2022
- Author(s)
  Hagihara K, Nunomura K, Lin B, Fumimoto M, Watanabe J, Mizuhara Y.
- Journal Title
  
  GENE
  
  Volume: 815 Pages: 146178-146178
- DOI
  10.1016/j.gene.2021.146178
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07937
[Journal Article] Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells2020
- Author(s)
  Imai Ryota、Horita Shoichiro、Ono Yuko、Hagihara Keisuke、Shimizu Masaru、Maejima Yuko、Shimomura Kenju
- Journal Title
  
  BioResearch Open Access
  
  Volume: 9 Issue: 1 Pages: 116-120
- DOI
  10.1089/biores.2019.0034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09840, KAKENHI-PROJECT-19K07937, KAKENHI-PROJECT-18K16544, KAKENHI-PROJECT-18K08483
[Journal Article] Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System2020
- Author(s)
  Shiying Jiang, Kousuke Baba, Tatsusada Okuno, Makoto Kinoshita, Chi-Jing Choong, Hideki Hayakawa, Hiroshi Sakiyama, Kensuke Ikenaka, Seiichi Nagano, Tsutomu Sasaki, Munehisa Shimamura, Yoshitaka Nagai, Keisuke Hagihara, Hideki Mochizuki
- Journal Title
  
  Neurotherapeutics
  
  Volume: 17 Issue: 1 Pages: 1-14
- DOI
  10.1007/s13311-020-00948-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07937, KAKENHI-PROJECT-17K09299, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20K07865
[Journal Article] フレイル・サルコペニア対策における漢方補腎薬の役割について2018
- Author(s)
  萩原圭祐
- Journal Title
  
  臨床栄養
  
  Volume: 132 Pages: 295-302
- Data Source
  KAKENHI-PROJECT-15K08912
[Journal Article] 総説　神経障害性疼痛に対する牛車腎気丸の分子薬理機序の解明　脊髄活性化ミクログリア由来のTNF-αを抑制して痛みを軽減する2018
- Author(s)
  中西美保, 中江文, 岸田友紀, 萩原圭祐, 福井聖, 北川裕利
- Journal Title
  
  痛みと漢方
  
  Volume: 28 Pages: 22-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11107
[Journal Article] 妄想型統合失調症の陰性症状に対して加味逍遥散と補中益気湯が有効であった1症例2017
- Author(s)
  中西美保, 岸田友紀, 田上真次, 馬場孝輔, 萩原圭祐
- Journal Title
  
  日本東洋医学雑誌
  
  Volume: 68(4) Pages: 352-357
- NAID
  130006338104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11107
[Journal Article] An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in severe muscle dystrophy model mice2017
- Author(s)
  Yusei Takemoto, Shoya Inaba, Lidan Zhang, Kousuke Baba, Keisuke Hagihara, So-ichiro Fukada'Correspondence information about the author So-ichiro FukadaEmail the author So-ichiro Fukada
- Journal Title
  
  Clinical Nutrition Experimental
  
  Volume: 16 Pages: 13-23
- DOI
  10.1016/j.yclnex.2017.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08912
[Journal Article] 腎虚と補腎剤2017
- Author(s)
  山本亜沙子、中田英之、萩原圭祐
- Journal Title
  
  アンチ・エイジング医学
  
  Volume: 13 Pages: 40-45
- Data Source
  KAKENHI-PROJECT-15K08912
[Patent] フレイル予測診断スコア(腎虚スコア)の開発2020
- Inventor(s)
  萩原圭祐、梶本勝文
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-081907
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K07937
[Patent] 筋の老化防止用組成物2015
- Inventor(s)
  萩原圭祐
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015
- Acquisition Date
  2017
- Data Source
  KAKENHI-PROJECT-15K08912
[Presentation] フレイル・サルコペニア対策における漢方医学の役割2021
- Author(s)
  萩原圭祐
- Organizer
  高知県整形外科医会（三木会）学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 心と体のレジリエンス(回復力）を高める漢方医学～漢方補腎薬の抗サルコペニア作用について～2021
- Author(s)
  萩原圭祐
- Organizer
  第9回京街道漢方研究会学術集会.
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 融合医学によるフレイル・サルコペニア対策について2021
- Author(s)
  萩原圭祐
- Organizer
  第29回外科漢方フォーラム学術集会日本脳神経外科漢方医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 心と体のレジリエンス(回復力）を高める漢方医学～漢方補腎薬の抗サルコペニア作用について～2021
- Author(s)
  萩原圭祐
- Organizer
  第59回全国自治体病院学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 融合医学によるフレイル・サルコペニア対策について2020
- Author(s)
  萩原圭祐
- Organizer
  第62回日本老年医学会学術集会漢方Geriatric　レクチャー
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 漢方補腎薬の抗フレイル効果の検証に向けての我々の取り組み～腎虚スコアの開発2020
- Author(s)
  梶本勝文、小林美亜、大佐賀智、中野真依、斎藤仁美、竹内麻里子、中田英之、萩原圭祐
- Organizer
  第7回日本サルコペニア・フレイル学会大会
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 消化器医が注意すべき超高齢化社会におけるサルコペニア・フレイル対策2020
- Author(s)
  萩原圭祐
- Organizer
  第17回日本消化管学会総会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07937
[Presentation] 心と体のレジリエンスを高める漢方医学　漢方補腎薬の抗サルコペニア効果について2017
- Author(s)
  萩原圭祐
- Organizer
  第1回日本リハビリテーション医学会秋季学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08912
[Presentation] フレイル・サルコペニア対策における漢方補腎薬の役割について2017
- Author(s)
  萩原圭祐
- Organizer
  第17回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08912
[Presentation] フレイル・サルコペニア対策での漢方医学の役割2017
- Author(s)
  萩原圭祐
- Organizer
  第34回和漢医薬学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08912
[Presentation] Bio-plex cytokine arrayによる肺高血圧患者におけるサイトカインの病態意義の解析
- Author(s)
  萩原圭祐
- Organizer
  第５６回日本リウマチ学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪
- Data Source
  KAKENHI-PROJECT-23591462

1. 岸田友紀 (20423163)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. Nakanishi Miho (40382048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 室田浩之 (90363499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 田中敏郎 (40273651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 有光潤介 (60457009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉岡芳親 (00174897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中江文 (60379170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 小山なつ (50135464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 梶本勝文 (30403067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 中田英之 (50730884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 原田和生 (50397741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NUNOMURA Kazuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松原広己

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIMOMURA Kenju

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAGIHARA Keisuke 萩原 圭祐

Research Projects

Research Products

Co-Researchers

Analysis of active components in the anti-sarcopenia effect of Goshajinkigan and the bacterial flora contributing to its metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the gut flora in the treatment with Gosha-jinki-Gan using metagenomics.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the analgesic mechanism of Japanese herbal medicine resulting from changes in brain plasticity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel anti-sarcopenia agent using drug re-positioning method with iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腸炎モデルマウスを用いた大建中湯の腸管免疫系への影響についての検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathology of the pulmonary hypertension with connective tissue disease using cytokine arrayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 漢方がみちびく心と体のレジリエンス（回復力）2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] フレイル・サルコペニア対策における漢方補腎薬の役割について2018

Author(s)

Journal Title

Data Source

[Journal Article] 総説 神経障害性疼痛に対する牛車腎気丸の分子薬理機序の解明 脊髄活性化ミクログリア由来のTNF-αを抑制して痛みを軽減する2018

Author(s)

Journal Title

Data Source

[Journal Article] 妄想型統合失調症の陰性症状に対して加味逍遥散と補中益気湯が有効であった1症例2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in severe muscle dystrophy model mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 腎虚と補腎剤2017

HAGIHARA Keisuke 萩原圭祐

[Journal Article] 総説　神経障害性疼痛に対する牛車腎気丸の分子薬理機序の解明　脊髄活性化ミクログリア由来のTNF-αを抑制して痛みを軽減する2018

[Presentation] 心と体のレジリエンスを高める漢方医学　漢方補腎薬の抗サルコペニア効果について2017