Shoda Takuji 正田卓司

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SYODA Takuji 正田卓司

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Researcher Number	60435708
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 有機化学部, 室長
Affiliation (based on the past Project Information) *help	2025: 国立医薬品食品衛生研究所, 有機化学部, 室長 2019 – 2023: 国立医薬品食品衛生研究所, 有機化学部, 室長 2016: 国立医薬品食品衛生研究所, 有機化学部, 室長 2014 – 2015: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 2011 – 2012: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 … More 2010: 国立医薬品食品衛生研究所, 有磯化学部, 主任研究員 2009: 国立医薬品食品衛生研究所, 有機化学部, 主任研究員 2006 – 2008: 国立医薬品食品衛生研究所, 有機化学部, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 選択的エストロゲン受容体分解薬 / タモキシフェン / 乳がん治療薬 / 分析 / 糖鎖 / 蛍光 / 誘導体化試薬 / O結合型糖鎖 / 医薬分子設計 / 乳がん … More / SERD / エストロゲン受容体 / TNBC / アンタゴニスト / 創薬化学 / 選択的エストロゲン受容体分解誘導剤 … More Except Principal Investigator 活性酸素 / ポリフェノール / 酸化ストレス / カテキン / 抗酸化剤 / chemoorevention / oxidatiye stress / reactive oxygen species / polyphenol / flavonoid / catechin / antioxidant / アポトーシス / 予防物質 / フラボノイド / レスベートロール / アルツハマー / アルツハイマー / 生活習慣病 / ビタミンE / アルツハイマー病 Less

新規蛍光性糖鎖誘導体化試薬の開発Principal Investigator
- Principal Investigator
  
  正田卓司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Health Sciences
新規高感度O型糖鎖誘導体化試薬の開発Principal Investigator
- Principal Investigator
  
  正田卓司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Health Sciences
Development of selective nuclear receptor downregulatorPrincipal Investigator
- Principal Investigator
  
  Shoda Takuji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
選択的エストロゲン受容体分解薬の効率的分子デザイン法の開発Principal Investigator
- Principal Investigator
  
  正田卓司
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Development of novel anti-breast cancer drugs that can induce degradation of estrogen receptorPrincipal Investigator
- Principal Investigator
  
  Shoda Takuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Studies on synthetic antioxidants for prevention of oxidative stress-related diseases
- Principal Investigator
  
  FUKUHARA Kiyoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design and Synthesis of Antioxidant for a New Type of Chemopreventive Agents
- Principal Investigator
  
  KIYUOSHI Fukuhara
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2012 2011 2007 Other

All Journal Article Presentation

[Journal Article] Approach to Establishment of Control Strategy for Oral Solid Dosage Forms Using Continuous Manufacturing2021
- Author(s)
  Ishimoto Hayato、Kano Manabu、Sugiyama Hirokazu、Takeuchi Hirofumi、Terada Katsuhide、Aoyama Atsushi、Shoda Takuji、Demizu Yosuke、Shimamura Jinen、Yokoyama Reiji、Miyamoto Yuji、Hasegawa Koji、Serizawa Masaru、Unosawa Kazuomi、Osaki Kazuo、Asai Naochika、Matsuda Yoshihiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 2 Pages: 211-217
- DOI
  10.1248/cpb.c20-00824
- NAID
  130007979432
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 7 Pages: 1411-1424.e7
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K21408
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 219 Issue: 9 Pages: 1-23
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237, KAKENHI-ORGANIZER-18H05497
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals (Basel).
  
  Volume: 13 Issue: 3 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 14 Issue: 12 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017
- Author(s)
  Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Med. Chem.
  
  Volume: 13 Issue: 3 Pages: 206-213
- DOI
  10.2174/1573406412666160805101408
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol pharmacol
  
  Volume: 91 Issue: 3 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton2017
- Author(s)
  T. Misawa, T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, Masaaki Kurihara
- Journal Title
  
  MedChemComm
  
  Volume: 8 Issue: 1 Pages: 239-246
- DOI
  10.1039/c6md00553e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169
[Journal Article] Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator2016
- Author(s)
  Takuji Shoda, Masashi Kato, Takuma Fujisato, Takashi Misawa, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 13 Pages: 2914-2919
- DOI
  10.1016/j.bmc.2016.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K18916
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 20 Pages: 4865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators2015
- Author(s)
  T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 13 Pages: 3091-3096
- DOI
  10.1016/j.bmc.2015.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-25430164
[Journal Article] An Activity-Based Probe for Studying Crosslinking in Live Bacteria2015
- Author(s)
  Samir Gautam, Taehan Kim, Takuji Shoda, Sounok Sen, Deeksha Deep, Ragini Luthra, Maria Teresa Ferreira, Mariana G. Pinho, David A. Spiegel
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 54 Issue: 36 Pages: 10492-10496
- DOI
  10.1002/ange.201503869
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860085
[Journal Article] Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides2015
- Author(s)
  H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 15 Pages: 2241-2245
- DOI
  10.1016/j.tet.2015.02.076
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability2014
- Author(s)
  Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 8 Pages: 2403-2408
- DOI
  10.1016/j.bmc.2014.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.2014
- Author(s)
  Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 24 Issue: 1 Pages: 87-89
- DOI
  10.1016/j.bmcl.2013.11.078
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Illuminating HIV-1 gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules2014
- Author(s)
  5.Christopher G. Parker, Markus K. Dahlgren, Don T. Li, Eugene F. Douglass, Takuji Shoda, Navneet Jawanda, Krasimir A. Spasov, Robert A. Domaoal, Richard Sutton, Karen S. Anderson, William L. Jorgensen, David A. Spiegel
- Journal Title
  
  Chemical Science
  
  Volume: 5 Issue: 6 Pages: 2311-2317
- DOI
  10.1039/c4sc00484a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860085
[Journal Article] Sphingosine-1-phosphate regulates cancer stem cell phenotype via Notch signaling2014
- Author(s)
  Hirata N., Yamada S., Shoda T., Kurihara M., Sekino Y., and Kanda Y.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 4806-4806
- DOI
  10.1038/ncomms5806
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670041, KAKENHI-PROJECT-26860085
[Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.2014
- Author(s)
  2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
- Journal Title
  
  Bioconjug Chem.
  
  Volume: 25 Issue: 11 Pages: 1921-24
- DOI
  10.1021/bc500480e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 4 Pages: 1793-1796
- DOI
  10.1016/j.bmcl.2011.11.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
[Journal Article] Enzyme-assisted synthesis of the glucuronide conjugate of psilocin, a hall ucinogenic component of magic mushroom2011
- Author(s)
  T.Shoda
- Journal Title
  
  Drug Test.Analysis
  
  Volume: 3 Issue: 9 Pages: 594-596
- DOI
  10.1002/dta.244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038
[Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy2007
- Author(s)
  K. Fukuhara, S. Oikawa, N. Hakota, Y. Sakai, Y. Hiraku. T. Shoda, S. Saito, N. Miyata, S. Kawanishi, H. Okuda
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 3869-3873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] エキシマー蛍光を利用した蛍光性糖鎖標識試薬の開発2023
- Author(s)
  正田卓司，橋井則貴，原園景，石井明子，出水庸介
- Organizer
  第42回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-22K06559
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的アンタゴニストの開発2022
- Author(s)
  正田卓司，出水庸介
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2022
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] エキシマー蛍光を利用した蛍光性糖鎖標識試薬の開発2022
- Author(s)
  2.伊藤海結，関根優莉奈，正田卓司，橋井則貴，原園景，石井明子，井上英史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-22K06559
[Presentation] 長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発2021
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2021
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] 疎水性タグを利用した標的タンパク質分解誘導剤によるE3リガーゼ依存/非依存タンパク質分解に関する検討2020
- Author(s)
  正田卓司，大岡伸通，辻厳一郎，井上英史，内藤幹彦，出水庸介
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] 長鎖アルキル基を有するエストロゲン受容体分解誘導剤のERサブタイプ選択性に関する検討2020
- Author(s)
  津田萌菜，正田卓司，井上英史，出水庸介
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] LSD類縁体MiPLAの合成とその性状解析2020
- Author(s)
  正田卓司，河村麻衣子，花尻（木倉）瑠理，袴塚高志，出水庸介
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K07009
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  3.沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 選択的エストロゲン受容体分解薬の分子設計2017
- Author(s)
  1.正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 芳香族炭化水素受容体を利用したプロテインノックダウン法のメカニズム解析2017
- Author(s)
  2.藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 芳香族炭化水素受容体を利用したプロテインノックダウン法のメカニズム解析2017
- Author(s)
  藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 選択的エストロゲン受容体分解薬の分子設計2017
- Author(s)
  正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 長鎖アルキル基を有する新規エストロゲン受容体分解誘導剤の合成と評価2016
- Author(s)
  正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  反応と合成のシンポジウム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規プロテインノックダウン分子の創製2016
- Author(s)
  8.藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  バイオ関連化学シンポジウム，
- Place of Presentation
  金沢
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発2016
- Author(s)
  6.藤里卓磨，正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発2016
- Author(s)
  正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 長鎖アルキル基を有する新規エストロゲン受容体分解誘導剤の合成と評価2016
- Author(s)
  4.正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  反応と合成のシンポジウム
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] Hisタグタンパク質分解誘導分子の開発2016
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規プロテインノックダウン分子の創製2016
- Author(s)
  藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  バイオ関連化学シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016
- Author(s)
  10.正田卓司，奥平桂一郎，内藤幹彦，栗原正明
- Organizer
  がん分子標的治療薬学会
- Place of Presentation
  大分
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発2016
- Author(s)
  藤里卓磨，正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規プロテインノックダウン法の開発2016
- Author(s)
  藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 細胞内Hisタグタンパク質分解誘導剤の開発2016
- Author(s)
  5.沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 網羅的人工ユビキチン修飾システムの構築2016
- Author(s)
  服部隆行, 正田卓司, 奥平桂一郎, 柴田識人, 大岡伸通, 伊藤進, 栗原正明,内藤幹彦
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016
- Author(s)
  服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
- Organizer
  日本生化学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 長鎖アルキル基を利用した新規エストロゲン受容体分解誘導剤の創製2016
- Author(s)
  7.正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  バイオ関連化学シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 長鎖アルキル基を利用した新規エストロゲン受容体分解誘導剤の創製2016
- Author(s)
  正田卓司，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  バイオ関連化学シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016
- Author(s)
  正田卓司，奥平桂一郎，内藤幹彦，栗原正明
- Organizer
  がん分子標的治療薬学会
- Place of Presentation
  大分
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016
- Author(s)
  9.服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
- Organizer
  日本生化学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K18916
[Presentation] 細胞内Hisタグタンパク質分解誘導剤の開発，日本薬学会関東支部会2016
- Author(s)
  沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] Naphthoflavoneを利用した新規プロテインノックダウン法の開発2015
- Author(s)
  藤里卓磨，正田卓司，大岡伸通，井上英史，内藤幹彦，栗原正明
- Organizer
  メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] Hisタグタンパク質応答性蛍光プローブの開発2015
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  ケミカルバイオロジー第10回年会
- Place of Presentation
  仙台
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators2015
- Author(s)
  Takuji Shoda, Masashi Kato, Keiichiro Okuhira, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Organizer
  PasifiChem2015
- Place of Presentation
  Honolulu
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発2015
- Author(s)
  正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] タモキシフェン骨格を有するエストロゲン受容体分解誘導剤の構造活性最適化研究2014
- Author(s)
  加藤雅士，正田卓司，奥平桂一郎，井上英史，内藤幹彦，栗原正明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 細胞内Hisタグタンパク質応答性蛍光プローブの開発2014
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] DNA cleaving activity of nitroimidazole under photoirradiation2007
- Author(s)
  T. Shoda, K. Miura, Y. Sakai, S. Saito, H. Okuda, K. Fukahara
- Organizer
  127th Annual Meeting of the Pharmaceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] ニトロイミダゾール誘導体の光照射下におけるDNA切断2007
- Author(s)
  正田卓司
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390033
[Presentation] 4,4,5,5,5-ペンタフルオロペンチル基を有するタモキシフェン誘導体のエストロゲン受容体分解誘導活性の評価
- Author(s)
  加藤雅士，正田卓司，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] 細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] タモキシフェン骨格を有する分解誘導剤のアルキル鎖長および末端構造の最適化
- Author(s)
  正田卓司，加藤雅士，藤里卓磨，原田麟太郎，奥平桂一郎，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860085
[Presentation] アルキル基の長さに着目したエストロゲン受容体分解誘導剤の構造最適化研究
- Author(s)
  加藤雅士，正田卓司，奥平桂一郎，井上英史，内藤幹彦，栗原正明
- Organizer
  第32会メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26860085

1. FUKUHARA Kiyoshi (70189968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. UMEMURA Takashi (50185071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OKUDA Haruhiro (30160807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. OHNO Akiko (70356236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. OBA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. DEMIZU YOSUKE

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
7. KANDA Yasunari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 内藤幹彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shoda Takuji 正田 卓司

SYODA Takuji 正田 卓司

Research Projects

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Co-Researchers

新規蛍光性糖鎖誘導体化試薬の開発Principal Investigator

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新規高感度O型糖鎖誘導体化試薬の開発Principal Investigator

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Development of selective nuclear receptor downregulatorPrincipal Investigator

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選択的エストロゲン受容体分解薬の効率的分子デザイン法の開発Principal Investigator

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Development of novel anti-breast cancer drugs that can induce degradation of estrogen receptorPrincipal Investigator

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Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

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Design and Synthesis of Antioxidant for a New Type of Chemopreventive Agents

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[Journal Article] Approach to Establishment of Control Strategy for Oral Solid Dosage Forms Using Continuous Manufacturing2021

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[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021

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[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020

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[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020

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[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019

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[Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017

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Shoda Takuji 正田卓司

SYODA Takuji 正田卓司