Akimoto Miho 秋元美穂

… Alternative Names

秋元美穂アキモトミホ

AKIMOTO Miho 秋元美穂

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Researcher Number	60437556
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 帝京大学, 医学部, 講師 2023: 帝京大学, 医学部, 講師 2017 – 2022: 帝京大学, 医学部, 助教 2016: 島根大学, 医学部, 助教 2012 – 2014: 島根大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / General pharmacology / Digestive surgery Except Principal Investigator Basic Section 50010:Tumor biology-related / Endocrinology
Keywords	Principal Investigator 大腸がん / IL-33 / インターロイキン－３３ / 膵がん / がん微小環境 / 転移抑制 / 性差 / 腸内細菌叢 / 脂肪由来肝細胞 / インターロイキン-33 … More / 肥満 / 老化 / 脂肪組織由来幹細胞 / 可溶性IL-33受容体 / HIF / 増殖抑制 / sST2 / インターロイキン－３３受容体 / GATA3 / インターロイキンー３３ / 低酸素 / アポトーシス / アディポネクチン受容体アゴニスト / カルシウム / ROS / 細胞死 / 経口投与 / 腫瘍血管形成 / ネクロプトーシス / アディポネクチン / 抗腫瘍効果 / ネクロトーシス / AdipoRon / 予後予測 / サイトカイン … More Except Principal Investigator 腫瘍微小環境 / 膵臓がん / 腫瘍増殖 / アディポネクチン / 皮下移植 / マウス膵臓がん細胞株 / sST2 / IL-33 / CaSR / 次世代シークエンシング / ゲノム解析 / 異所性ホルモン産生腫瘍 / PTH / lncRNA Less

IL-33による腸内細菌叢の性差形成が大腸がん病態・病理の性差に及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  秋元美穂
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Teikyo University
膵臓がんの同所及び異所性腫瘍微小環境内IL-33応答が腫瘍増殖に及ぼす影響の解析
- Principal Investigator
  
  竹永啓三
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
肥満および老化の脂肪幹細胞由来のIL-33が膵がんの悪性進展に及ぼす影響の解析Principal Investigator
- Principal Investigator
  
  秋元美穂
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Teikyo University
Analysis of the effect of hypoxia-induced downregulation of soluble IL-33 receptor on malignant progression of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Akimoto Miho
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Teikyo University
Expression of Parathyroid-specific Novel lncRNA and Paucity of CaSR Characterize an Ectopic PTH-producing Tumor.
- Principal Investigator
  
  岡崎具樹
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Teikyo University
Analysis of antitumor effects of adiponectin receptor agonists on pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Akimoto Miho
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Teikyo University
  Shimane University
Antimetastatic effects of a soluble IL-33 receptor and its utility as a prognostic biomarker in colorectal cancer.Principal Investigator
- Principal Investigator
  
  AKIMOTO Miho
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Shimane University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation

[Journal Article] Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway2023
- Author(s)
  Akimoto Miho、Susa Takao、Okudaira Noriyuki、Koshikawa Nobuko、Hisaki Harumi、Iizuka Masayoshi、Okinaga Hiroko、Takenaga Keizo、Okazaki Tomoki、Tamamori-Adachi Mimi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 118
- DOI
  10.1073/pnas.2218033120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07217, KAKENHI-PROJECT-22K09485, KAKENHI-PROJECT-22K11788, KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-19K11651
[Journal Article] A novel LncRNA PTH-AS upregulates interferon-related DNA damage resistance signature genes and promotes metastasis in human breast cancer xenografts2022
- Author(s)
  Akimoto Miho、Susa Takao、Okudaira Noriyuki、Hisaki Harumi、Iizuka Masayoshi、Okinaga Hiroko、Okazaki Tomoki、Tamamori-Adachi Mimi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 7 Pages: 102065-102065
- DOI
  10.1016/j.jbc.2022.102065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-19K11651, KAKENHI-PROJECT-22K09485, KAKENHI-PROJECT-22K11788, KAKENHI-PROJECT-19K09699
[Journal Article] Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice2021
- Author(s)
  Takenaga Keizo、Akimoto Miho、Koshikawa Nobuko、Nagase Hiroki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 2923-2923
- DOI
  10.1038/s41598-021-82617-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-20H03540
[Journal Article] MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target2021
- Author(s)
  Takenaga Keizo、Koshikawa Nobuko、Akimoto Miho、Tatsumi Yasutoshi、Lin Jason、Itami Makiko、Nagase Hiroki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 13302
- DOI
  10.1038/s41598-021-92772-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03540, KAKENHI-PROJECT-19K07408, KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-20K08199
[Journal Article] Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model2020
- Author(s)
  Takenaga K、Akimoto M、Koshikawa N、Nagase H
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 4 Pages: e0232230-e0232230
- DOI
  10.1371/journal.pone.0232230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21177, KAKENHI-PROJECT-19K07673, KAKENHI-PROJECT-20H03540
[Journal Article] 25(OH)D<sub>3</sub> stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated2020
- Author(s)
  Kikuyama T, Susa T, Tamamori-Adachi M, Iizuka M, Akimoto M, Okinaga H, Fujigaki Y, Uchida S, Shibata S, Okazaki T.
- Journal Title
  
  J Steroid Biochem Mol Biol .
  
  Volume: 199 Pages: 105593-105593
- DOI
  10.1016/j.jsbmb.2020.105593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09699, KAKENHI-PROJECT-19K11651, KAKENHI-PROJECT-19H03678, KAKENHI-PROJECT-17K09891, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-19K22643
[Journal Article] Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis2018
- Author(s)
  17.Akimoto M, Maruyama R, Kawabata Y, Tajima Y, Takenaga K.
- Journal Title
  
  Cell Death & Disease
  
  Volume: 9 Issue: 8 Pages: 804-804
- DOI
  10.1038/s41419-018-0851-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21177, KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K10595
[Journal Article] Role of the IL-33/ST2L axis in colorectal cancer progression2018
- Author(s)
  Akimoto Miho、Takenaga Keizo
- Journal Title
  
  Cellular Immunology
  
  Volume: 343 Pages: 103740-103740
- DOI
  10.1016/j.cellimm.2017.12.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K21177
[Journal Article] HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression2017
- Author(s)
  Harashima Nanae、Takenaga Keizo、Akimoto Miho、Harada Mamoru
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 26 Pages: 42887
- DOI
  10.18632/oncotarget.17157
- NAID
  120006532063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-17K07217, KAKENHI-PROJECT-16K21177
[Journal Article] Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer2017
- Author(s)
  Koshikawa Nobuko、Akimoto Miho、Hayashi Jun-Ichi、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 15535-15535
- DOI
  10.1038/s41598-017-15592-2
- NAID
  120007134603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K21177, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-17H03602
[Journal Article] Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer2016
- Author(s)
  Akimoto M, Hayashi JI, Nakae S, Saito H, Takenaga K.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 7 Issue: 1 Pages: e2057-e2057
- DOI
  10.1038/cddis.2015.418
- NAID
  120007129640
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430110, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16K21177
[Journal Article] Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment2016
- Author(s)
  Akimoto M, Maruyama R, Takamaru H, Ochiya T, Takenaga K.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 13589-13589
- DOI
  10.1038/ncomms13589
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K21177
[Journal Article] Anticancer Effect of Ginger Extract Against Pancreatic Cancer Cells Mainly Through Reactive Oxygen Species-Mediated Autotic Cell Death2015
- Author(s)
  Miho Akimoto, Mari Iizuka, Rie Kanematsu, Masato Yoshida, Keizo Takenaga
- Journal Title
  
  PLOS ONE
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24791422
[Journal Article] Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism2013
- Author(s)
  Hattori M, Kawakami K, Akimoto M, Takenaga K, Suzumiya J, Honma Y.
- Journal Title
  
  Tumori
  
  Volume: 99(2) Pages: 239-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791422
[Journal Article] An inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells2013
- Author(s)
  Akimoto M, Nagasawa H, Hori H, Uto Y, Honma Y, Takenaga K.
- Journal Title
  
  World J Med Genet
  
  Volume: 3(4) Issue: 4 Pages: 41-54
- DOI
  10.5496/wjmg.v3.i4.41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791422, KAKENHI-PROJECT-25430110
[Journal Article] Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells2013
- Author(s)
  Shimojo Y, Akimoto M, Hisanaga T, Tanaka T, Tajima Y, Honma Y, Takenaga K.
- Journal Title
  
  Clin Exp Metastasis
  
  Volume: 30 Issue: 2 Pages: 143
- DOI
  10.1007/s10585-012-9519-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] マウス膵臓がん細胞におけるIL-33デコイ受容体sST2の発現低下は皮下腫瘍の増殖を促進する2024
- Author(s)
  秋元　美穂、越川　信子、安達　三美、竹永　啓三
- Organizer
  第８３回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06644
[Presentation] Hypoxia-induced downregulation of sST2 in CRC cells: its molecular mechanisms and role in tumor growth and metastasis2023
- Author(s)
  秋元美穂, 奥平准之, 越川信子, 竹永啓三, 安達（玉盛）三美
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07217
[Presentation] Hypoxia-induced downregulation of sST2 in CRC cells: its molecular mechanisms and role in tumor growth and metastasis2023
- Author(s)
  秋元美穂, 奥平准之, 越川信子, 竹永啓三, 安達（玉盛）三美
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 低酸素下の大腸がん細胞における腫瘍抑制生sST2発現低下とその回復による腫瘍増殖と転移の抑制2023
- Author(s)
  秋元美穂, 諏佐崇生, 奥平准之, 越川信子, 久樹晴美, 飯塚眞由, 竹永啓三, 安達（玉盛）三美
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07217
[Presentation] 可溶性インターロイキン－３３受容体の大腸がん低酸素領域限定的な発現誘導による抗腫瘍および抗転移効果2023
- Author(s)
  秋元美穂, 諏佐崇生, 奥平准之, 越川信子, 久樹晴美, 飯塚眞由, 竹永啓三, 安達（玉盛）三美
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K07217
[Presentation] 低酸素下の大腸がん細胞における腫瘍抑制性sST2発現低下とその回復による腫瘍増殖と転移の抑制2023
- Author(s)
  秋元美穂, 諏佐崇生, 奥平准之, 越川信子, 久樹晴美, 飯塚眞由, 竹永啓三, 安達（玉盛）三美
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 可溶性インターロイキン－３３受容体の大腸がん低酸素領域限定的な発現誘導による抗腫瘍および抗転移効果2023
- Author(s)
  秋元美穂, 諏佐崇生, 奥平准之, 越川信子, 久樹晴美, 飯塚眞由, 竹永啓三, 安達（玉盛）三美
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] A novel lncRNA downstream of the parathyroid hormone gene promotes breast cancer malignancy via upregulation of STAT1.2022
- Author(s)
  秋元美穂、奥平准之
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07217
[Presentation] A novel lncRNA downstream of the parathyroid hormone gene promotes breast cancer malignancy via upregulation of STAT1.2022
- Author(s)
  秋元美穂、奥平准之
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 大腸がん低酸素領域限定的な可溶性IL-33受容体発現の回復は腫瘍の増殖と転移を抑制する．2022
- Author(s)
  秋元美穂、諏佐崇、奥平准之、岡崎具樹、安達三美
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 大腸がん低酸素領域限定的な可溶性IL-33受容体発現の回復は腫瘍の増殖と転移を抑制する．2022
- Author(s)
  秋元美穂、諏佐崇生、奥平准之、岡崎具樹、安達三美
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07217
[Presentation] 加齢に伴うマウスコルチコステロン濃度の変化と制御機構2021
- Author(s)
  久樹晴美、諏佐崇生、奥平准之、秋元美穂、安達（玉盛）三美、内田俊也、岡崎具樹
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 加齢に伴うマウスコルチコステロン濃度の変化と制御機構2021
- Author(s)
  奥平准之、秋元美穂（医学部4年）、諏佐崇生、秋元美穂、久樹晴美、飯塚眞由、岡崎具樹、安達（玉盛）三美
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] Restoration of sST2 expression in hypoxic CRC cells suppresses tumor growth by changing inflammatory microenvironment2021
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 老化細胞除去薬によるコルチコステロン濃度の制御2021
- Author(s)
  奥平准之、秋元美穂（医学部4年）、諏佐崇生、秋元美穂、久樹晴美、飯塚眞由、岡崎具樹、安達（玉盛）三美
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] Analysis of the mechanism of hypoxia-induced sST2 downregulation in colorectal cancer cells and its effect on tumor growth2021
- Author(s)
  秋元美穂、藤井美沙紀、豊嶋歩実、諏佐崇生、奥平准之、久樹晴美、飯塚眞由、竹永啓三、渡部多真紀、安野伸浩、岡崎具樹、安達（玉盛）三美
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] ヒト前立腺癌細胞にてHOXC9はARの阻害因子として機能する2021
- Author(s)
  諏佐崇生、大野くるみ、秋元美穂、奥平准之、飯塚眞由、渡部多真紀、安野伸浩、岡崎具樹、安達（玉盛）三美
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 低酸素下の大腸がん細胞における腫瘍抑制性sST2の発現低下のメカニズムと腫瘍増殖に及ぼす影響の解析2021
- Author(s)
  秋元美穂、藤井美沙紀、豊嶋歩実、諏佐崇生、奥平准之、久樹晴美、飯塚眞由、竹永啓三、渡部多真紀、安野伸浩、岡崎具樹、安達（玉盛）三美
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 異所性副甲状腺ホルモン産生悪性線維性組織球腫で検出された新規lncRNAの解析2020
- Author(s)
  秋元美穂、諏佐崇生、安達（玉盛）三美、飯塚真由、岡崎具樹
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 大腸がん細胞において核内のIL-33はGATA3への結合を介して腫瘍抑制性sST2の発現を低酸素下で抑制する2020
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 異所性副甲状腺ホルモン産生悪性線維性組織球腫で検出された新規lncRNAの解析2020
- Author(s)
  秋元美穂、諏佐崇生、安達（玉盛）三美、飯塚眞由、岡崎具樹
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 加齢による糖質コルチコイド分泌撹乱のメカニズムの解析2020
- Author(s)
  安達（玉盛）三美、諏佐崇生、久樹晴美、秋元美穂、飯塚眞由、岡崎具樹
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] The change of steroidogenesis with aging in mouse adrenal gland2020
- Author(s)
  奥平准之、諏佐崇生、秋元美穂、久樹晴美、西森茂樹、飯塚眞由、岡崎具樹、安達（玉盛）三美
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 25(OH)D3は腎細胞においてビタミンD3活性を発揮する2019
- Author(s)
  4.諏佐崇生、菊山崇浩、安達（玉盛）三美、秋元美穂、飯塚眞由、内田俊也、柴田茂、岡崎具樹
- Organizer
  第92回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 大腸がん細胞における低酸素誘導性sST2発現低下のメカニズムの解明2019
- Author(s)
  秋元美穂、竹永啓三、岡崎具樹
- Organizer
  第17回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 大腸癌細胞におけるIL-33低酸素誘導性核集積による腫瘍抑制性sST2の発現抑制2019
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 大腸癌細胞におけるIL-33低酸素誘導性核集積による腫瘍抑制性sST2の発現抑制2019
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07673
[Presentation] 時計関連遺伝子群が、糖質コルチコイド分泌撹乱に伴う諸組織の老化に緊密に関与する2019
- Author(s)
  2.安達（玉盛）三美、諏佐崇生、久樹晴美、秋元美穂、飯塚真由、岡崎具樹
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] 大腸がん細胞における低酸素誘導性sST2発現低下のメカニズムの解明2019
- Author(s)
  秋元美穂、竹永啓三、岡崎具樹
- Organizer
  第17回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] sST2, a decoy receptor, enhances orthotopic tumor growth of murine pancreatic cancer cells2018
- Author(s)
  Takenaga K, Akimoto M
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 高 Ca クリーゼをきたした異所性 PTH 産生悪性線維性組織球腫2018
- Author(s)
  内田香介、秋元美穂、田中祐司、市川仁、永江玄太、油谷浩幸、諏佐崇生、安達（玉盛）三美、岡崎具樹、飯塚眞由
- Organizer
  第22回日本臨床内分泌病理学会
- Data Source
  KAKENHI-PROJECT-17K09891
[Presentation] Hypoxia downregulates tumor-suppressive sST2 in CRC cells in an IL-33/HIF-dependent manner2018
- Author(s)
  Akimoto M, Takenaga K
- Organizer
  第７７回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 大腸がん細胞における腫瘍抑制性sST2発現のHIF/IL-33依存的抑制2018
- Author(s)
  秋元美穂, 岡崎具樹, 竹永啓三
- Organizer
  第１６回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 可溶性ST2は炎症性のがん微小環境を修飾し膵がん細胞の皮下増殖を抑制する2017
- Author(s)
  秋元美穂、岡崎具樹、竹永啓三
- Organizer
  第15回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 肺癌・大腸癌における病因性mtDNA ND遺伝子変異と転移との関連の再評価2017
- Author(s)
  越川信子、秋元美穂、永瀬浩喜、竹永啓三
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] AdipoRonはミトコンドリアカルシウムユニポーターによるCa2+の取り込みを介して膵がん細胞の細胞死を誘導する2017
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] ヒト癌におけるミトコンドリアND遺伝子変異の病因性予測と遠隔転移との関連性の検討2017
- Author(s)
  越川信子、秋元美穂、林純一、永瀬浩喜、竹永啓三
- Organizer
  第15回がんとハイポキシア研究会
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 可溶性IL-33受容体sST2は大腸がん同所移植モデルにおいて腫瘍増殖および肝転移を抑制する2016
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] mtDNA変異が制御する転移の予測因子としての乳酸トランスポーターMCT4の核局在2016
- Author(s)
  越川信子、秋元美穂、植田健、飯笹俊彦、鍋谷圭宏、井内俊彦、永瀬浩喜、竹永啓三
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] IL-33はprogrammed oncosis耐性高転移性肺癌細胞をがん微小環境下において選別する2016
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第25回日本がん転移学会
- Place of Presentation
  米子コンベンションセンター（米子）
- Year and Date
  2016-07-21
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] 可溶性ST2は炎症性のがん微小環境の修飾を介して大腸がんの増殖および転移を抑制する2016
- Author(s)
  秋元美穂、丸山理留敬、竹永啓三
- Organizer
  第14回がんとハイポキシア研究会
- Place of Presentation
  岐阜グランドホテル（岐阜）
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] Nuclear localization of lactate transporter MCT4 could be a predictor of metastatsis regulated by mtDNA mutation.2016
- Author(s)
  Koshikawa N, Akimoto M, Ueda T, Iizasa T, Nebeya Y, Iuchi T, Nagase H, Takenaga K.
- Organizer
  第１４回がんとハイポキシア研究会
- Place of Presentation
  岐阜グランドホテル（岐阜）
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16K21177
[Presentation] Soluble ST2 inhibits tumor growth and metastasts of colon carcinoma cells by modulating inflammatory microenvironment2013
- Author(s)
  Miho Akimoto, Yoshio Honma, Keizo Takenaga
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜）
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] 可溶性IL-33受容体sST2による炎症性微小環境の修飾を介した大腸がんの転移の抑制2013
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  ホテルブエナビスタ松本（松本市）
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] 可溶性IL-33受容体ST2による炎症性微小環境の修飾を介した大腸がんの転移の抑制2013
- Author(s)
  秋元美穂、竹永啓三
- Organizer
  第22回日本がん転移学会学実総会・集会
- Place of Presentation
  ホテルブエナビスタ松本（松本）
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] N-Acetylcysteine suppresses hypoxia-induced EMT and hepatic metastasis of human pancreatic cancer cells2012
- Author(s)
  Yoshihide Shimojo, Miho Akimoto, Yoshitsugu Tajima, Yoshio Honma, Keizo Takenaga
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ホテルロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] Inhibition of tumor growth and metastasis of colon carcinoma cells by sST22012
- Author(s)
  Miho Akimoto, Yoshio Honma, Keizo Takenaga
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ホテルロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] Soluble ST2 modulates inflammatory tumor microenvironment and inhibits neoan giogenesis and growth of pancreatic cancer
- Author(s)
  Miho Akimoto, Mamoru Harada, Keizo Takenaga
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] 可溶性ST2は炎症性のがん微小環境を修飾し膵がんの増殖を抑制する
- Author(s)
  秋元　美穂、竹永　啓三
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  ホテルマリターレ創世（佐賀）
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] Enhancement of glycolysis and survival of lung carcinoma cells with mtDNA mutation co-cultured with stromal cells
- Author(s)
  Keizo Takenaga, Miho Akimoto
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] Inhibition of HIF-2α sensitizes human pancreatic cancer cells to TRAIL
- Author(s)
  Nanae Harashima, Yoko Hari, Hiroyuki Monma, Miho Akimoto, Keizo Takenaga, Yoshitsugu Tajima, Mamoru Harada
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] HIF-2αの阻害はヒト膵がん細胞のTRAIL感受性を増強する
- Author(s)
  原嶋　奈々江、秋元　美穂、竹永　啓三、原田　守
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  ホテルマリターレ創世（佐賀）
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24791422
[Presentation] 膵臓がん細胞に対する生姜抽出物の抗腫瘍効果
- Author(s)
  兼松里衣、秋元美穂、竹永敬三
- Organizer
  日本生薬学会第61回年会
- Place of Presentation
  福岡大学（福岡）
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-24791422

1. 岡崎具樹 (60203973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 竹永啓三 (80260256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 越川信子 (90260249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Akimoto Miho 秋元 美穂

秋元 美穂 アキモト ミホ

AKIMOTO Miho 秋元 美穂

Research Projects

Research Products

Co-Researchers

IL-33による腸内細菌叢の性差形成が大腸がん病態・病理の性差に及ぼす影響の解明Principal Investigator

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膵臓がんの同所及び異所性腫瘍微小環境内IL-33応答が腫瘍増殖に及ぼす影響の解析

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肥満および老化の脂肪幹細胞由来のIL-33が膵がんの悪性進展に及ぼす影響の解析Principal Investigator

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Analysis of the effect of hypoxia-induced downregulation of soluble IL-33 receptor on malignant progression of colorectal cancerPrincipal Investigator

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Expression of Parathyroid-specific Novel lncRNA and Paucity of CaSR Characterize an Ectopic PTH-producing Tumor.

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Analysis of antitumor effects of adiponectin receptor agonists on pancreatic cancerPrincipal Investigator

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Antimetastatic effects of a soluble IL-33 receptor and its utility as a prognostic biomarker in colorectal cancer.Principal Investigator

Principal Investigator

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[Journal Article] Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway2023

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[Journal Article] A novel LncRNA PTH-AS upregulates interferon-related DNA damage resistance signature genes and promotes metastasis in human breast cancer xenografts2022

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[Journal Article] Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice2021

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[Journal Article] MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target2021

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[Journal Article] Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model2020

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[Journal Article] 25(OH)D<sub>3</sub> stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated2020

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[Journal Article] Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis2018

Author(s)

Akimoto Miho 秋元美穂

秋元美穂アキモトミホ

AKIMOTO Miho 秋元美穂