Tokinaga Yasuyuki 時永泰行

… Alternative Names

時永泰行トキナガヤスユキ

TOKINAGA Yasuyuki 時永泰行

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Researcher Number	60438281
Other IDs	https://orcid.org/0000-0003-4255-9788
Affiliation (Current)	2026: 和歌山県立医科大学, 医学部, 准教授 2026: 札幌医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2026: 和歌山県立医科大学, 医学部, 准教授 2023 – 2024: 和歌山県立医科大学, 医学部, 准教授 2021 – 2022: 和歌山県立医科大学, 医学部, 講師 2017 – 2019: 札幌医科大学, 医学部, 講師 2015: 札幌医科大学, 医学部, 助教 2013: 札幌医科大学, 医学部, 助教 2007 – 2010: Wakayama Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology / Anesthesiology/Resuscitation studies Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 麻酔薬 / 内皮グリコカリックス / 吸入麻酔薬 / 血管内皮 / グリコカリックス / 一塩基多型 / Pharmacogenetics / UDP-Glucuronosvltransferase 1A9 / 遺伝子頻度 / 薬物代謝 … More / SNP / 遺伝子発現 / プロポフォール / 遺伝子多型 … More Except Principal Investigator 心房性ナトリウム利尿ペプチド / 輸液 / 内皮グリコカリックス / TRPV1 / 掻痒 / 末梢神経 / IL-31RA / Tmem45b / 痒み / IL-31 / 揮発性麻酔薬 / アストロサイト / グルタミン酸 / カルシウムオシレーション Less

セボフルランによる内皮グリコカリックス回復機序の解明Principal Investigator
- Principal Investigator
  
  時永泰行
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Wakayama Medical University
Investigation of the mechanism of recovery effect of anesthetics on endothelial glycocalyx damagePrincipal Investigator
- Principal Investigator
  
  時永泰行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Wakayama Medical University
Elucidation of Mechanisms Causing Endothelial Glycocalyx Disruption and Development of New Infusion Strategies
- Principal Investigator
  
  Yamasaki Keiko
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Wakayama Medical University
Investigation of itch transmission in peripheral nerves for the development of novel molecular-targeted itch therapies
- Principal Investigator
  
  Tomoyuki Maruyama
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Wakayama Medical University
The restoring effect of anesthetics on damaged-endothelial glycocalyxPrincipal Investigator
- Principal Investigator
  
  Tokinaga Yasuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Sapporo Medical University
The restoring effect of anesthetics on damaged-endothelial glycocalyxPrincipal Investigator
- Principal Investigator
  
  Tokinaga Yasuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Sapporo Medical University
The effect of volatile anesthetics on calcium oscillation in astrocyte
- Principal Investigator
  
  YOSHIMURA Seiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Wakayama Medical University
The effect of genetic polymor phism on propofol metabolismPrincipal Investigator
- Principal Investigator
  
  TOKINAGA Yasuyuki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Wakayama Medical University

All 2025 2019 2018 2017 2015 2010

All Journal Article Presentation Book

[Book] 医学のあゆみ2015
- Author(s)
  時永泰行, 山蔭道明
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25462444
[Journal Article] Sevoflurane promotes regeneration of the endothelial glycocalyx by upregulating ｓｉａｌｙｌｔｒａｎｓｆｅｒａｓｅ2019
- Author(s)
  ＫａｚｕｍａＳ，ＴｏｋｉｎａｇａＹ，ＫｉｍｉｚｕｋａＭ，ＡｚｕｍａｇｕｃｈｉＲ，ＨａｍａｄａＫ，ＹａｍａｋａｇｅＭ
- Journal Title
  
  ＪｏｕｒｎａｌｏｆＳｕｒｇｉｃａｌＲｅｓｅａｒｃｈ
  
  Volume: 241 Pages: 40-47
- DOI
  10.1016/j.jss.2019.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K20106, KAKENHI-PROJECT-17K11057
[Journal Article] 血管透過性と内皮グリコカリックス．2018
- Author(s)
  時永泰行，数馬聡，山蔭道明
- Journal Title
  
  救急・集中治療エキスパートに学ぶショック管理のすべて．
  
  Volume: 3 Pages: 343-348
- Data Source
  KAKENHI-PROJECT-17K11057
[Journal Article] 内皮グリコカリックス障害が発生する？ー今後の輸液戦略のキーワードー2017
- Author(s)
  時永泰行、数馬　聡、山蔭道明
- Journal Title
  
  救急・集中治療
  
  Volume: 29 Pages: 327-332
- Data Source
  KAKENHI-PROJECT-17K11057
[Presentation] 急速輸液の内皮グリコカリックス、内皮依存性弛緩反応に対する影響2025
- Author(s)
  澤田　拓、時永泰行、山崎景子、角南省吾、丸山智之、川股知之
- Organizer
  日本麻酔科学会　第７２回学術集会、神戸
- Data Source
  KAKENHI-PROJECT-22K09169
[Presentation] セボフルランは酸化ストレスによるグリコカリックスの障害および血管内皮依存性弛緩反応の減弱をシアル酸転移酵素ST6Gal-Ⅰの発現増強を介して回復させる．2018
- Author(s)
  数馬聡，時永泰行，君塚基修，東口隆，濱田耕介，山蔭道明
- Organizer
  日本麻酔科学会北海道・東北支部第8回学術集会
- Data Source
  KAKENHI-PROJECT-17K11057
[Presentation] セボフルランは酸化ストレスによる血管内皮依存性弛緩反応およびグリコカリックスの障害を回復させる．2018
- Author(s)
  数馬聡，時永泰行，東口隆，君塚基修，濱田耕介，山蔭道明
- Organizer
  第33回体液・代謝管理研究会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K11057
[Presentation] 内皮グリコカリックス障害による血管内皮依存性弛緩作用の抑制に及ぼすセボフルランの影響．2015
- Author(s)
  本間舞子，時永泰行，数馬聡，林俊輔，山蔭道明
- Organizer
  日本麻酔科学会北海道・東北支部第５回学術集会
- Place of Presentation
  ホテルニューキャッスル（弘前市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25462444
[Presentation] プロポフォール代謝酵素遺伝子における1塩基多型の検討2010
- Author(s)
  時永泰行、木本吉紀、小川幸志、谷奥匡、江尻加名子、畑埜義雄
- Organizer
  社団法人日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡(日本)
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-19791085
[Presentation] The Allelic frequenciea of Propofol-Metabolize Enzyme Gene in Japanese Population2010
- Author(s)
  Yasuyuki Tokinaga, M.D., Yoshiki Kimoto, M.D., Kazuhisa Suhimoto, M.D., Koji Ogawa, M.D., Yoshio Hatano, M.D.
- Organizer
  American Society of Anesthesiologists Annuai Meeting 2010
- Place of Presentation
  San Diego, CaLIFORNIA USA
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-19791085
[Presentation] プロポフォール代謝酵素遺伝子における1塩基多型の検討2010
- Author(s)
  時永泰行、木本吉紀, ら
- Organizer
  社団法人日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-19791085
[Presentation] The Allelic Frequencies of Propofol-Metabolize Enzyme Gene in Japanese Population2010
- Author(s)
  Y.Tokinaga, Y.Kimoto, et al.
- Organizer
  American Society of Anesthesiologists Annual Meeting 2010
- Place of Presentation
  San Diego, California
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-19791085

1. Edanaga Mitsutaka (70616169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Yamasaki Keiko (10886948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. YOSHIMURA Seiko (40468286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Tomoyuki Maruyama (00894883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tokinaga Yasuyuki 時永 泰行

時永 泰行 トキナガ ヤスユキ

TOKINAGA Yasuyuki 時永 泰行

Research Projects

Research Products

Co-Researchers

セボフルランによる内皮グリコカリックス回復機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of recovery effect of anesthetics on endothelial glycocalyx damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Mechanisms Causing Endothelial Glycocalyx Disruption and Development of New Infusion Strategies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of itch transmission in peripheral nerves for the development of novel molecular-targeted itch therapies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The restoring effect of anesthetics on damaged-endothelial glycocalyxPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The restoring effect of anesthetics on damaged-endothelial glycocalyxPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of volatile anesthetics on calcium oscillation in astrocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of genetic polymor phism on propofol metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Sevoflurane promotes regeneration of the endothelial glycocalyx by upregulating ｓｉａｌｙｌｔｒａｎｓｆｅｒａｓｅ2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血管透過性と内皮グリコカリックス．2018

Author(s)

Journal Title

Data Source

[Journal Article] 内皮グリコカリックス障害が発生する？ー今後の輸液戦略のキーワードー2017

Author(s)

Journal Title

Data Source

[Presentation] 急速輸液の内皮グリコカリックス、内皮依存性弛緩反応に対する影響2025

Author(s)

Organizer

Data Source

[Presentation] セボフルランは酸化ストレスによるグリコカリックスの障害および血管内皮依存性弛緩反応の減弱をシアル酸転移酵素ST6Gal-Ⅰの発現増強を介して回復させる．2018

Author(s)

Organizer

Data Source

Tokinaga Yasuyuki 時永泰行

時永泰行トキナガヤスユキ

TOKINAGA Yasuyuki 時永泰行

[Presentation] セボフルランは酸化ストレスによる血管内皮依存性弛緩反応およびグリコカリックスの障害を回復させる．2018

[Presentation] 内皮グリコカリックス障害による血管内皮依存性弛緩作用の抑制に及ぼすセボフルランの影響．2015