Takakusagi Yoichi 高草木洋一

… Alternative Names

TAKAKUSAGI Yoichi 高草木洋一

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Researcher Number	60439916
Other IDs	https://orcid.org/0000-0002-6786-0748
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, グループリーダー
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, グループリーダー 2022 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員 2021: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 主幹研究員 2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 主任研究員(任常) 2019: 国立研究開発法人量子科学技術研究開発機構, その他部局等, 研究員 … More 2016 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 主任研究員(任常) 2015: 東京大学, 工学(系)研究科(研究院), 研究員 2008: Tokyo University of Science, 理工学部, 助教 2007: Tokyo University of Science, 理工学部・応用生物科学科, 助教 Less
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / Basic Section 52040:Radiological sciences-related / Radiation science / Chemistry related to living body Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 超偏極 / がん / 代謝 / 放射線 / 核磁気共鳴 / 放射線増感剤 / 個別化医療 / イメージング / 動的核偏極 / 酸素 … More / MRI / 血管新生 / 診断カクテル / 代謝診断治療 / 増感剤 / 化学放射線療法 / ペプチダーゼ / 血管 / 放射線治療 / ピルビン酸 / 低酸素標的薬 / 電子スピン共鳴 / 動的可視化 / 赤血球 / 造影剤 / 酸素飽和度 / ヘモグロビン / BOLD / CEST / NMR / QCM / ロキシスロマイシ / イリノテカン / カンプトテシン / ケミカルバイオロジー / 動的作用機構 / hnRNP A3 / hEP1 受容体 / アンジオモチン(Amot) / ロキシスロマイシンRXM / カンプトテシン(CPT) / 抗腫瘍活性 / ファージディスプレイ法 / 受容体化学 … More Except Principal Investigator 3D培養 / 大腸癌 / セラノスティクス / 癌代謝 / 超偏極13CMRI / 非臨床POC / 社会実装 / DNP-MRI / がん代謝 / 胃がん / 大腸がん Less

Innovation of cancer chemoradiotherapy based on hyperpolarized-nuclear magnetic resonance metabolic imagingPrincipal Investigator
- Principal Investigator
  
  高草木洋一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.
- Principal Investigator
  
  大嶋野歩
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Study for next-generation precision medicine based on the highly targeted theranostics for the pathological neovascularization of cancersPrincipal Investigator
- Principal Investigator
  
  Takakusagi Yoichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  National Institutes for Quantum Science and Technology
A model study for personalized cancer medicine by the novel chemoradiotherapy guided on the state-of-the-art spin resonance imagingPrincipal Investigator
- Principal Investigator
  
  Takakusagi Yoichi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Monitoring of the hemoglobin oxygen saturation via the ultra-high sensitive NMR signalsPrincipal Investigator
- Principal Investigator
  
  Takakusagi Yoichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
  The University of Tokyo
Validation of protein-drug interactions identified by the phage display technologyPrincipal Investigator
- Principal Investigator
  
  TAKAKUSAGI Yoichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tokyo University of Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2009 2008 2007

All Journal Article Presentation Book

[Book] 「蛋白質核酸酵素」7月号新実験講座2009
- Author(s)
  高草木洋一, 他
- Total Pages
  7
- Publisher
  共立出版株式会社
- Data Source
  KAKENHI-PROJECT-19750145
[Book] 蛋白質核酸酵素7月号新実験講座2009
- Author(s)
  高草木洋一、高草木香織、菅原二三男、坂口謙吾
- Total Pages
  7
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Novel Structure-guided Design of Amino Acid Based Hyperpolarized 13C Probes for Metabolic Imaging2023
- Author(s)
  Kazutoshi Yamamoto, Yutaro Saito, Hiroyuki Yatabe, Norikazu Koyasu, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Akihiro Eguchi, Yoichi Takakusagi, Nobu Oshima, Murali C. Krishna, Shinsuke Sando
- Journal Title
  
  Proc. ISMRM
  
  Volume: 31 Pages: 0845-0845
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Journal Article] Hypersensitive MR Metabolic Imaging Realized by Means of Dynamic Nuclear Polarization (DNP)2023
- Author(s)
  高草木洋一
- Journal Title
  
  The Brain & Neural Networks
  
  Volume: 30 Issue: 4 Pages: 179-188
- DOI
  10.3902/jnns.30.179
- ISSN
  1340-766X, 1883-0455
- Year and Date
  2023-12-05
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-23K27561
[Journal Article] EPR and Related Magnetic Resonance Imaging Techniques in Cancer Research2023
- Author(s)
  Yoichi Takakusagi, Ryoma Kobayashi, Keita Saito, Shun Kishimoto, Murali C. Krishna, Ramachandran Murugesan, Ken-ichiro Matsumoto
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 1 Pages: 69-69
- DOI
  10.3390/metabo13010069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Journal Article] Design and Development of the Molecular Probes for Application of the Hyperpolarized-NMR/MRI2022
- Author(s)
  Yoichi Takakusagi
- Journal Title
  
  JPS Conf Proc
  
  Volume: 37 Pages: 021301-021301
- DOI
  10.7566/jpscp.37.021301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0369
[Journal Article] Structure-based relaxation analysis reveals C-terminal [1-13C]glycine-d2 in peptides has long spin-lattice relaxation time that is applicable to in vivo hyperpolarized magnetic resonance studies2022
- Author(s)
  Yohei Kondo, Yutaro Saito, Tomohiro Seki, Yoichi Takakusagi, Jumpei Morimoto, Hiroshi Nonaka, Koichiro Miyanishi, Wataru Mizukami, Makoto Negoro, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Masayuki Matsuo, Natarajan Raju, Rolf Swenson, Murali C. Krishna, Kazutoshi Yamamoto, Shinsuke Sando
- Journal Title
  
  ChemRxiv
  
  Volume: -
- DOI
  10.26434/chemrxiv-2022-tfkk1
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15396, KAKENHI-PROJECT-19H00919, KAKENHI-PROJECT-19J22848, KAKENHI-PROJECT-19KK0369
[Journal Article] Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging2022
- Author(s)
  Kawai Tatsuya、Matsuo Masayuki、Takakusagi Yoichi、Saito Keita、Hyodo Fuminori、Devasahayam Nallathamby、Matsumoto Shingo、Kishimoto Shun、Yasui Hironobu、Yamamoto Kazutoshi、Krishna Murali C.
- Journal Title
  
  NMR in Biomedicine
  
  Volume: 35 Issue: 10 Pages: 4783-4783
- DOI
  10.1002/nbm.4783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07247, KAKENHI-PROJECT-22K07744, KAKENHI-PROJECT-19KK0369, KAKENHI-PROJECT-20KK0253, KAKENHI-PROJECT-20H00654, KAKENHI-PROJECT-20H03628, KAKENHI-PROJECT-23K24994
[Journal Article] Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo2022
- Author(s)
  Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
- Journal Title
  
  Science advances
  
  Volume: 8 Issue: 13
- DOI
  10.1126/sciadv.abj2667
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15396, KAKENHI-PUBLICLY-20H05090, KAKENHI-PROJECT-19H00919, KAKENHI-PROJECT-19KK0369, KAKENHI-PROJECT-20H03217, KAKENHI-PROJECT-20K09054, KAKENHI-PROJECT-18H01186
[Journal Article] The natural sulfoglycolipid derivative SQAP improves the therapeutic efficacy of tissue factor-targeted radioimmunotherapy in the stroma-rich pancreatic cancer model BxPC-32022
- Author(s)
  Yoichi Takakusagi, Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Masahiko Yasunaga, Yasuhiro Matsumura, Fumio Sugawara, Kengo Sakaguchi, Tatsuya Higashi
- Journal Title
  
  Translational Oncology
  
  Volume: 15 Issue: 1 Pages: 191285-191285
- DOI
  10.1016/j.tranon.2021.101285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0369
[Journal Article] Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging2021
- Author(s)
  Yohei Kondo, Hiroshi Nonaka, Yoichi Takakusagi, Shinsuke Sando
- Journal Title
  
  Angew. Chem. Int. Ed. (Review/総説）
  
  Volume: 60 Issue: 27 Pages: 2-23
- DOI
  10.1002/anie.201915718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00919, KAKENHI-PROJECT-19J22848, KAKENHI-PROJECT-19KK0369
[Journal Article] 超偏極-核磁気共鳴代謝イメージングと生命科学・医療への応用展開2020
- Author(s)
  高草木洋一
- Journal Title
  
  月刊OPTRONICS 8 月号
  
  Volume: 39 Pages: 79-83
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions2020
- Author(s)
  Yoichi Takakusagi
- Journal Title
  
  J Vis Exp
  
  Volume: 166 Issue: 166
- DOI
  10.3791/61873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] Phage display technology for target determination of small-molecule therapeutics: an update2020
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kengo Sakaguchi, Fumio Sugawara
- Journal Title
  
  Expert Opin Drug Discov
  
  Volume: 15 Issue: 10 Pages: 1199-1211
- DOI
  10.1080/17460441.2020.1790523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] 含硫糖脂質 SQAG の放射線増感作用メカニズムの解明2019
- Author(s)
  高草木洋一、Sarwat Naz、高草木香織、坂口謙吾、菅原二三男、James B Mitchell、Murali C Krishna
- Journal Title
  
  第 61 回天然有機化合物討論会講演要旨集
  
  Volume: 09 Pages: 511-516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] Using the QCM Biosensor-Based T7 Phage Display Combined with Bioinformatics Analysis for Target Identification of Bioactive Small Molecule2018
- Author(s)
  Takakusagi, Y. Takakusagi, K. Sugawara, F. Sakaguchi, K.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1795 Pages: 159-172
- DOI
  10.1007/978-1-4939-7874-8_14
- ISBN
  9781493978731, 9781493978748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response2018
- Author(s)
  Takakusagi, Y. Naz, S. Takakusagi, K. Ishima, M. Murata, H. Ohta, K. Miura, M. Sugawara, F. Sakaguchi, K. Kishimoto, S. Munasinghe, J. P. Mitchell, J. B. Krishna, M. C.
- Journal Title
  
  Cancer Res
  
  Volume: 78 Issue: 24 Pages: 6828-6837
- DOI
  10.1158/0008-5472.can-18-1654
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] Hyperpolarized [1-13C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect2018
- Author(s)
  Scroggins B, Matsuo M, White A, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Ichikawa K, Mitchell JB, Cherukuri MK, Citrin DE
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 印刷中 Issue: 13 Pages: 3137-3148
- DOI
  10.1158/1078-0432.ccr-17-1957
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03035, KAKENHI-PROJECT-17K01363
[Journal Article] Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies2018
- Author(s)
  Yoichi Takakusagi, Shun Kishimoto, Sarwat Naz, Shingo Matsumoto, Keita Saito, Charles P. Hart, James B. Mitchell, Murali C. Krishna
- Journal Title
  
  Antioxid Redox Signal
  
  Volume: 28 Issue: 2 Pages: 131-140
- DOI
  10.1089/ars.2017.7106
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice2018
- Author(s)
  Matsumoto, S. Kishimoto, S. Saito, K. Takakusagi, Y. Munasinghe, J. P. Devasahayam, N. Hart, C. P. Gillies, R. J. Mitchell, J. B. Krishna, M. C.
- Journal Title
  
  Cancer Res
  
  Volume: 78 Issue: 14 Pages: 3783-3792
- DOI
  10.1158/0008-5472.can-18-0491
- NAID
  120006651800
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Journal Article] A Strategy to Design Hyperpolarized 13C Magnetic Resonance Probes Using [1-13C]alpha-Amino Acid as a Scaffold Structure.2017
- Author(s)
  T. Nishihara, Y. Kameyama, H. Nonaka, Y. Takakusagi, F. Hyodo, K. Ichikawa, S. Sando
- Journal Title
  
  Chem. Asian J.
  
  Volume: 印刷中 Issue: 9 Pages: 949-953
- DOI
  10.1002/asia.201700098
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03449, KAKENHI-PROJECT-15K21218
[Journal Article] Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity2016
- Author(s)
  Ryunosuke Hata, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 55 Issue: 5 Pages: 1765-1768
- DOI
  10.1002/anie.201509457
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218, KAKENHI-PROJECT-13J06653, KAKENHI-PROJECT-26560215
[Journal Article] Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution2016
- Author(s)
  Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo, and Kazuhiro Ichikawa
- Journal Title
  
  J Magn Reson
  
  Volume: 270 Pages: 157-160
- DOI
  10.1016/j.jmr.2016.07.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K21218, KAKENHI-PROJECT-15H03035
[Journal Article] 13C-MR spectroscopic imaging with hyperpolarized [1-13C]pyruvate detects early response to radiotherapy in SCC tumors and HT-29 tumors2015
- Author(s)
  Keita Saito, Shingo Matsumoto, Yoichi Takakusagi, Masayuki Matsuo, H. Douglas Morris, Martin J. Lizak, Jeeva P. Munasinghe, Nallathamby Devasahayam, Sankaran Subramanian, James B. Mitchell, Murali C. Krishna,
- Journal Title
  
  Clin Cancer Res
  
  Volume: 21 Issue: 22 Pages: 5073-5081
- DOI
  10.1158/1078-0432.ccr-14-1717
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Journal Article] Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions2015
- Author(s)
  Ryunosuke Hata, Hiroshi Nonaka, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando
- Journal Title
  
  Chem Commun (Camb)
  
  Volume: 51 Issue: 61 Pages: 12290-12292
- DOI
  10.1039/c5cc04597e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218, KAKENHI-PROJECT-13J06653, KAKENHI-PROJECT-26560215, KAKENHI-PROJECT-15H03035
[Journal Article] Self assembled monolayer (SAM) of small-molecule to efficiently select binding-peptide from phage library using a quartz-crystal microbalance (QCM) device2009
- Author(s)
  Yoichi Takakusagi, Aiko Suzuki, Fumio Sugawara, Kengo Sakaguchi
- Journal Title
  
  Proc. of ICCE 17(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device2008
- Author(s)
  Yoichi Takakusagi, Yuki Kuroiwa, Fumio Sugawara, Kengo Sakaguchi
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 7410-7414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool2008
- Author(s)
  Takakusagi Y., et.al.
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 9837-9846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device2008
- Author(s)
  Takakusagi Y., et.al.
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 7410-7414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool2008
- Author(s)
  Yoichi Takakusagi, Kouji Kuramochi, Manami Takagi, Tomoe Kusayanagi, Daisuke Manita et al
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 9837-9846
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device.2007
- Author(s)
  Takakusagi Y., et. al.
- Journal Title
  
  Bioorg. Med. Chem. 15(24)
  
  Pages: 7590-7598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Journal Article] Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device2007
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kouji Kuramochi, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi
- Journal Title
  
  Bioorg.Med. Chem 15
  
  Pages: 7590-7598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] 超偏極 MRI/NMR 利活用テストベッドの整備状況と代謝診断治療の創成に向けた取り組み2024
- Author(s)
  高草木洋一
- Organizer
  第二回 DNP 研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] 超偏極 MRI による in vivo 酸素濃度測定のための長寿命分子の評価2024
- Author(s)
  足利留樹、齋藤雄太朗、谷田部浩行、近藤洋平、野中洋、高草木洋一、山本和俊、Murali C. Krishna、山東信介
- Organizer
  日本化学会第 104 春季年会 (2024)
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] 超偏極の臨床と前臨床のあいだ: 実用化に向けて必要なこと2024
- Author(s)
  高草木洋一
- Organizer
  第 6 回基礎と臨床をつなぐ MR 研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] 精密に設計された超偏極分子プローブ群を用いる複数のアミノペプチダーゼ活性の生体内同時検出2024
- Author(s)
  谷田部浩行、齋藤雄太朗、高草木洋一、齋藤圭太、山本和俊、Murali C. Krishna、山東信介
- Organizer
  日本化学会第 104 春季年会 (2024)
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] 量子計測技術としての動的核偏極法と超高感度代謝イメージング2023
- Author(s)
  高草木洋一
- Organizer
  第 45 回日本生物学的精神医学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] Development of a Hyperpolarized Molecular Probe for Aminopeptidase N Activity Applicable in vivo2023
- Author(s)
  Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C Krishna, Shinsuke Sando
- Organizer
  Asian Chemical Biology Conference 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 医用画像診断のフロンティア: 量子技術により実現する巨視的代謝イメージング2023
- Author(s)
  高草木洋一
- Organizer
  名古屋大学医工若手研究者交流会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極-核磁気共鳴法による生体内ペプチダーゼ活性の検出および可視化を指向した分子プローブの設計と開発2023
- Author(s)
  谷田部浩行, 近藤洋平, 田村伊織, 石田諒, 関智宏, 高草木洋一, Elhelaly Abdelazim E., 大嶋野歩, 兵藤文紀, 松尾政之, 山本和俊, Krishna Murali C., 齋藤雄太朗, 山東信介
- Organizer
  日本分子イメージング学会第 17 回年会 2
- Data Source
  KAKENHI-PROJECT-23K08153
[Presentation] 量子超偏極-核磁気共鳴法: 日本初の成果導出に向けて2023
- Author(s)
  高草木洋一
- Organizer
  JSMRM スタディーグループ「量子超偏極の生命科学と知的基盤形成」
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極 13C-MRI/NMR 計測システムの立ち上げと基礎検討2023
- Author(s)
  齋藤圭太、小林竜馬、柴田さやか、高草木洋一
- Organizer
  量子生命科学会　第 5 回大会
- Data Source
  KAKENHI-PROJECT-23K27561
[Presentation] Novel Structure-guided Design of Amino Acid Based Hyperpolarized 13C Probes for Metabolic Imaging2023
- Author(s)
  Kazutoshi Yamamoto, Yutaro Saito, Hiroyuki Yatabe, Norikazu Koyasu, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Akihiro Eguchi, Yoichi Takakusagi, Nobu Oshima, Murali C. Krishna, Shinsuke Sando
- Organizer
  ISMRM2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極-核磁気共鳴法による生体内ペプチダーゼ活性の検出および可視化を指向した分子プローブの設計と開発2023
- Author(s)
  谷田部浩行、近藤洋平、田村伊織、石田諒、関智宏、高草木洋一、Abdelazim E. Elhelaly、大島野歩、兵藤文紀、松尾政之、山本和俊、Murali C. Krishna、齋藤雄太朗、山東信介
- Organizer
  第17回　日本分子イメージング学会　学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] Hyperpolarized MR Facility in the Institute for Quantum Life Science, QST2022
- Author(s)
  Yoichi Takakusagi
- Organizer
  DNP Mini Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 量子生命科学 (量子イメージング) の研究開発と医療応用2022
- Author(s)
  高草木洋一
- Organizer
  第 12 回放射線生物学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極MRIによる腫瘍内ピルビン酸代謝イメージング2022
- Author(s)
  齋藤圭太 , 高草木洋一 , 小林竜馬
- Organizer
  量子生命科学先端フォーラム 2022 年冬の研究会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極－核磁気共鳴法: 今何が新しいのか？2022
- Author(s)
  高草木洋一
- Organizer
  電通大＆量子生命合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] A newly designed hyperpolarized molecular probe enables the in vivo detection of aminopeptidase N activity from the tumor regions in animals2022
- Author(s)
  Hiroyuki Yatabe, Yutaro Saito, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
- Organizer
  World Molecular Imaging Congress 2022 (WMIC 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 低分子化合物を基軸とした診断治療技術の開発2022
- Author(s)
  高草木洋一
- Organizer
  千葉大学膜タンパク質研究センター × 量子科学技術研究開発機構量子生命科学研究所第 11 回合同勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] Inducing or Accessing Vasculature2022
- Author(s)
  高草木洋一
- Organizer
  日本放射線腫瘍学会第 35 回学術大会シンポジウム7 ”Hallmarks of cancer” から読み解く放射線生物学
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] がん研究における低温超偏極 MRI/NMR の応用2022
- Author(s)
  高草木洋一
- Organizer
  DNP 研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] triplet法による超偏極MRIを支える技術2022
- Author(s)
  小林竜馬 , 高草木洋一 , 齋藤圭太
- Organizer
  量子生命科学先端フォーラム 2022 年冬の研究会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 量子技術を用いた超高感度 MRI/NMR ~QST 千葉地区における取り組み~2022
- Author(s)
  根来誠 , 高草木洋一 , 高堂裕平 , 小林竜馬 , 齋藤圭太 , 菊池達矢 , 小野麻衣子 , 柴田さやか , 富安もよこ , 小畠隆行
- Organizer
  量子生命科学先端フォーラム 2022 年冬の研究会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 量子生命棟超偏極エリアの紹介2022
- Author(s)
  高草木洋一
- Organizer
  第 2 回磁気共鳴医学会スタディーグループミーティング「臨床応用を指向する超偏極・代謝 MRI イメージング」
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 動的核偏極－核磁気共鳴法　~分子代謝と生命現象の谷間をつなぐ新たな架け橋~2021
- Author(s)
  高草木洋一
- Organizer
  バイオインダストリー奨励賞受賞者企画講演会　~生命現象の根本的解明を目指す量子生命科学について~
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏極[1-13C]ピルビン酸核磁気共鳴分光法と代謝イメージングによる前立腺がんのエネルギー代謝解析と治療効果予測2021
- Author(s)
  高草木洋一、松尾政之、高草木香織、井上香織、兵藤文紀、Murali C. Krishna、市川和洋
- Organizer
  第 15 回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 緩和機構の理解に基づく実用的な量子超偏極-核磁気共鳴分子プローブの設計2021
- Author(s)
  谷田部浩行、近藤洋平、田村伊織、石田諒、関智宏、高草木洋一、大嶋野歩、兵藤文紀、松尾政之、山本和俊、Murali C. Krishna、齋藤雄太朗、山東信介
- Organizer
  量子生命科学会　第 3 回大会
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 超偏極－核磁気共鳴代謝イメージング: 次世代の画像診断技術としての応用に向けて2021
- Author(s)
  高草木洋一
- Organizer
  第 49 回日本磁気共鳴医学会大会教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] Design and development of the molecular probes for application of the hyperpolarized-NMR/MRI2021
- Author(s)
  Yoichi Takakusagi
- Organizer
  The 24th International Spin Symposium (SPIN2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] QST 量子超偏極 MRI グループ (最近の研究活動の紹介)2021
- Author(s)
  高草木洋一
- Organizer
  第 49 回日本磁気共鳴医学会大会スタディーグループ
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] Development of Hyperpolarized Molecular Probes for in vivo Detection of Peptidase Activities2021
- Author(s)
  Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Ryo Ishida, Yohei Kondo, Tomohiro Seki, Akihiro Eguchi, Yoichi Takakusagi, Kazutoshi Yamamoto, Murali C. Krishna, Shinsuke Sando
- Organizer
  PACIFICHEM2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] NIH 留学記: NIH の DNP 装置2021
- Author(s)
  高草木洋一
- Organizer
  第 49 回日本磁気共鳴医学会大会スタディーグループ
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0369
[Presentation] 生体内アミノペプチダーゼN活性を検出する超偏極分子プローブの開発2020
- Author(s)
  齋藤雄太朗 , 谷田部浩行 , 田村伊織 , 近藤洋平 , 石田諒 , 関智宏 , 江口晃弘 , 高草木洋一 , 山本和俊 , Murali C Krishna , 山東信介
- Organizer
  第 14 回バイオ関連化学シンポジウム 2020
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] QST 量子生命科学領域/量子超偏極 MRI グループの紹介2020
- Author(s)
  高草木洋一
- Organizer
  第 48 回日本磁気共鳴医学会大会超偏極による他核MRSIの高感度計測スタディーグループ
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 生体内ペプチダーゼ活性検出のための実用的量子超偏極 MRI 分子プローブ開発2020
- Author(s)
  齋藤雄太朗 , 谷田部浩行 , 田村伊織 , 近藤洋平 , 石田諒 , 関智宏 , 江口晃弘 , 高草木洋一 , 山本和俊 , Murali C. Krishna , 山東信介
- Organizer
  量子生命科学会第 2 回大会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 量子超偏極－核磁気共鳴分子プローブによるアミノペプチダーゼ N 及びアミノペプチダーゼ A 活性の同時検出2020
- Author(s)
  谷田部浩行 , 田村伊織 , 近藤洋平 , 高草木洋一 , 石田諒 , 山本和俊 , Murali C. Krishna , 齋藤雄太朗 , 山東信介
- Organizer
  量子生命科学会第 2 回大会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts2020
- Author(s)
  Tomohiro Seki , Kazutoshi Yamamoto , Nobu Oshima , Marino Itoda , Yohei Kondo , Yutaro Saito , Yoichi Takakusagi , Shun Kishimoto , Jeffery Brender , Ronja Malinowski , Jan Henrik Ardenkjaer-Larsen , Hiroshi Nonaka , Murali C Krishna , Shinsuke Sando
- Organizer
  ISMRM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts2020
- Author(s)
  Kazutoshi Yamamoto , Tomohiro Seki , Nobu Oshima , Marino Itoda , Yohei Kondo , Yutaro Saito , Yoichi Takakusagi , Shun Kishimoto , Jeffery Brender , Ronja Malinowski , Jan Henrik Ardenkjaer-Larsen , Hiroshi Nonaka , Murali Krishna , Shinsuke Sando
- Organizer
  61st ENC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 動的核偏極がもたらす新しいサイエンスと医療応用を求めて2020
- Author(s)
  高草木洋一
- Organizer
  大阪大学 CiNET セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏極－核磁気共鳴代謝イメージング: 分子プローブの開発と応用計測にみる課題と展望2020
- Author(s)
  高草木洋一
- Organizer
  量子生命科学会第 2 回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 生体内ペプチダーゼの活性を検出する超偏極分子プローブの開発2020
- Author(s)
  谷田部浩行 , 齋藤雄太朗 , 石田諒 , 田村伊織 , 近藤洋平 , 高草木洋一 , 山本和俊 , Murali C Krishna , 山東信介
- Organizer
  日本化学会第100 回春季年会 2020
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 生体内アミノペプチダーゼの活性を検出する超偏極分子プローブの開発2020
- Author(s)
  谷田部浩行 , 田村伊織 , 近藤洋平 , 高草木洋一 , 石田諒 , 山本和俊 , Murali C Krishna , 齋藤雄太朗 , 山東信介
- Organizer
  第 10 回 CSJ 化学フェスタ 2020
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 含硫糖脂質 SQAG の放射線増感作用メカニズムの解明2019
- Author(s)
  高草木洋一、Sarwat Naz、高草木香織、坂口謙吾、菅原二三男、James B Mitchell、Murali C Krishna
- Organizer
  第 61 回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 低分子有機化合物の魅力 ~探す、創る、使う~2019
- Author(s)
  高草木洋一
- Organizer
  第 1 回量子生命科学会若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] MR マイクロイメージングと Gd-デンドロン修飾ナノリポソーム造影剤を用いた 3D 微小血管系およびナノ粒子分布の腫瘍内評価2019
- Author(s)
  新田展大、高草木洋一、國領大介、柴田さやか、冨田章裕、東達也、青木伊知男、原田雅史
- Organizer
  第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] マルチモダル分子イメージングによる腫瘍内微小環境の多角的評価と天然由来含硫糖脂質の誘発する放射線増感作用メカニズムの解明2019
- Author(s)
  高草木洋一、松元慎吾、松尾政之、高草木香織、齋藤圭太、岸本俊、三浦雅彦、宮崎年恭、菅原二三男、坂口謙吾、James B Mitchell、Murali C Krishna
- Organizer
  第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 放射線研究における超偏極－核磁気共鳴分光法とイメージングの応用2019
- Author(s)
  高草木洋一
- Organizer
  日本放射線影響学会第 62 回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏極 13C MRI 代謝イメージングによる抗癌治療効果の予測2019
- Author(s)
  松元慎吾、齋藤圭太、高草木洋一、Murali C Krishna
- Organizer
  第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] スピン共鳴画像技術の基礎と応用2019
- Author(s)
  高草木洋一
- Organizer
  長崎国際大学薬学部薬品物理化学特別セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 生体内 β-ガラクトシダーゼ活性検出に向けた高感度-核磁気共鳴分子プローブの検討2019
- Author(s)
  近藤洋平、坂本大地、野中洋、高草木洋一、山本和俊、Murali C Krishna、青木伊知男、山東信介
- Organizer
  第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Dissolution-DNP の最先端研究拠点 DTU HYPERMAG Center2019
- Author(s)
  高草木洋一
- Organizer
  第 47 回日本磁気共鳴医学会大会超偏極による他核 MRSI の高感度計測
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Hyperpolarized-NMR/MRI in Japan2019
- Author(s)
  Yoichi Takakusagi
- Organizer
  Technical University of Denmark, HYPERMAG Center, lab seminar
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] A multimodal molecular imaging study of tumor microenvironment to reveal the mechanism of tumor radiosensitization elicited by a natural sulfoglycolipid2019
- Author(s)
  Yoichi Takakusagi, Shingo Matsumoto, Masayuki Matsuo, Kaori Takakusagi, Keita Saito, Shun Kishimoto, Masahiko Miura, Toshiyasu Miyazaki, Fumio Sugawara, Kengo Sakaguchi, James B Mitchell, Murali C Krishna
- Organizer
  第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Use of hyperpolarized magnetic resonance spectroscopy (HP-MRS) in cell and tissue engineering2018
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kaori Inoue, Kazuhiro Ichikawa
- Organizer
  5th Tissue Engineering and Regenerative Medicine International Society World Congress (TERMIS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Hyperpolarized [1-13C]pyruvate MRS reveals early-phase transition of energy metabolism in multicellular spheroid tumors2018
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kaori Inoue, Kazuhiro Ichikawa
- Organizer
  International Society for Magnetic Resonance in Medicine (ISMRM) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis2018
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kaori Inoue, Kazuhiro Ichikawa
- Organizer
  HYP18―An International Conference on Nuclear Hyperpolarization
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Monitoring effect of rapamaycin on pyruvate metabolism in SCC tumor using hyperpolarized 13C-MRI2018
- Author(s)
  Keita Saito, Shingo Matsumoto, Yoichi Takakusagi, Masayuki Matsuo, Hellmut Merkle, James B. Mitchell, Murali C. Krishna
- Organizer
  International Society for Magnetic Resonance in Medicine (ISMRM) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] スピン共鳴画像解析と新規化学放射線療法によるがんのセラノスティクス2018
- Author(s)
  高草木洋一
- Organizer
  第 12 回 QCM 研究会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 先端量子技術: 超偏極の最先端と実用化への期待2018
- Author(s)
  高草木洋一
- Organizer
  第 3 回 MRI アライアンス国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 最先端量子イメージングによる膵臓がん個別化医療のモデル研究2018
- Author(s)
  松元慎吾、高草木洋一、齋藤圭太、岸本俊、Mitchell J.B.、Hart C.P.、Gillies R.J.、Krishna M.C.
- Organizer
  第 2 回量子生命科学研究会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏ー[1-13C]ピルビン酸 MRS によるがんスフェロイドの初期エネルギー代謝変化の非侵襲計測2018
- Author(s)
  高草木洋一、高草木香織、井上香織、市川和洋
- Organizer
  第 46 回日本磁気共鳴医学会大会
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 画像診断と治療のコンビネーション: セラノスティクスとコンパニオン診断2018
- Author(s)
  高草木洋一
- Organizer
  第 115 回日本医学物理学会学術大会　早朝教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] QCM-T7 ファージディスプレイ法によるがん血管新生阻害剤の標的タンパク質および結合部位の同定2018
- Author(s)
  高草木香織、高草木洋一
- Organizer
  第 12 回 QCM 研究会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] バイオセンシングにより解き明かす生体内分子ダイナミクス2018
- Author(s)
  高草木洋一
- Organizer
  第 12 回 QCM 研究会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏極－核磁気共鳴分子プローブの創製と応用計測　~次世代画像診断技術としての実用化を目指して~2017
- Author(s)
  高草木洋一
- Organizer
  第 45 回磁気共鳴医学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Accessories and Techniques that Maximize MRI as a Quantum Technology2017
- Author(s)
  Yoichi Takakusagi
- Organizer
  A Workshop on Drawing Biological Information through Quantum Spin Systems (NCI/NIH Bldg10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 超偏極－核磁気共鳴分子プローブの創製と応用計測　~次世代画像診断技術としての実用化を目指して~2017
- Author(s)
  高草木洋一
- Organizer
  第 45 回磁気共鳴医学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] 動的核偏極－核磁気共鳴分子プローブの創製と応用計測2017
- Author(s)
  高草木洋一
- Organizer
  次世代 MRI・造影剤　キックオフ国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01363
[Presentation] Accessories and Techniques that Maximize MRI as a Quantum Technology2017
- Author(s)
  Yoichi Takakusagi
- Organizer
  A Workshop on Drawing Biological Information through Quantum Spin Systems
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] 革新的診断治療技術の創製をめざして2017
- Author(s)
  高草木洋一
- Organizer
  第 116 回 NIH 金曜会
- Place of Presentation
  NIH Bethesda Campus, Bethesda, MD
- Year and Date
  2017-02-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] 動的核偏極－核磁気共鳴分子プローブの創製と応用計測2017
- Author(s)
  高草木洋一
- Organizer
  次世代 MRI・造影剤　キックオフ国際シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy for noninvasive assessment of energy metabolism transition induced by the 3D spheroidal culture of tumor cells2017
- Author(s)
  Yoichi Takakusagi, Kaori Takakusagi, Kaori Inoue, Yoshimi Homma, Kazuhiro Ichikawa
- Organizer
  Gordon Research Conference (GRC), Physical Science of Cancer
- Place of Presentation
  Houston, TX
- Year and Date
  2017-02-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] アミノ酸をモチーフとした超偏極－核磁気共鳴分子プローブの設計と応用2016
- Author(s)
  高草木洋一
- Organizer
  第 44 回日本磁気共鳴医学会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2016-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Dissolution DNP-MRI 研究の概略と画像診断への応用2016
- Author(s)
  高草木洋一
- Organizer
  第 2 回超偏極ワーキンググループ
- Place of Presentation
  岐阜大学医学部
- Year and Date
  2016-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] DNP-MRI についての概説 (Dissolution-DNP-MRI についての概要説明)2016
- Author(s)
  高草木洋一
- Organizer
  DNP-MRI 代謝イメージングの基礎研究の発展と臨床応用研究に向けたワーキンググループ: キックオフミーティング
- Place of Presentation
  じゅうろくプラザ (岐阜)
- Year and Date
  2016-02-21
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] DNP MR imaging (糖代謝、その他)2016
- Author(s)
  高草木洋一
- Organizer
  第 6 回放射線生物学セミナー
- Place of Presentation
  名古屋市立大学医学部研究棟
- Year and Date
  2016-02-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] 超偏極スタディーセッション「超偏極－磁気共鳴分子プローブの設計」2015
- Author(s)
  高草木洋一
- Organizer
  第 43 回　日本磁気共鳴医学会
- Place of Presentation
  東京ドームホテル
- Year and Date
  2015-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Noninvasive assessment of drug actions in tumor microenvironment by the EPR oxygen imaging2015
- Author(s)
  Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Shun Kishimoto, Kaori Takakusagi, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Robert J. Gillies, Charles P. Hart, James B. Mitchell, Murali C. Krishna
- Organizer
  第 54 回電子スピンサイエンス学会年会 (SEST2015)
- Place of Presentation
  朱鷺メッセ (新潟)
- Year and Date
  2015-11-02
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Increase in tumor oxygenataion and radiosensitivity caused by SQAP (CG-0321): the mechanism of actions revealed by in vivo imaging studies2015
- Author(s)
  Yoichi Takakusagi, Shingo Matsumoto, Keita Saito, Masayuki Matsuo, Kaori Takakusagi, Shun Kishimoto, Masahiro Ishima, Hiroshi Murata, Keisuke Ohta, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, James B. Mitchell, Murali C. Krishna
- Organizer
  International Conference of Radiation Research (ICRR2015)
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Effect of ionic charge of gadolinium complex for polarization and spin-lattice relaxation of [13C] hyperpolarized chemical probes after dissolution2015
- Author(s)
  Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo, Kazuhiro Ichikawa
- Organizer
  5th DNP Symposium
- Place of Presentation
  Egmond ann Zee, Netherland
- Year and Date
  2015-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] 13C-MRI with hyperpolarized [1-13C]pyruvate detects metabolic changes in SCC tumors and HT-29 tumors by radiotherapy2015
- Author(s)
  Keita Saito, Shingo Matsumoto, Yoichi Takakusagi, Masayuki Matsuo, H. Douglas Morris, Martin J. Lizak, Jeeva P. Munasinghe, Nallathamby Devasahayam, Sankaran Subramanian, James B. Mitchell, Murali C. Krishna
- Organizer
  International Conference of Radiation Research (ICRR2015)
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] EPR based imaging biomarkers to guide treatment in tumor bearing mice2015
- Author(s)
  Shingo Matsumoto, Keita Saito, Shun Kishimoto, Yoichi Takakusagi, Hironobu Yasui, Masayuki Matsuo, Murali C. Krishna
- Organizer
  The 54th Annual Meeting of the Society of Electron Spin Science and Technology (SEST2015), International EPR Society Silver Medal Award Lecture
- Place of Presentation
  朱鷺メッセ (新潟)
- Year and Date
  2015-11-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21218
[Presentation] Camptothecins : Inhibition of the E-prostanoid receptor subtype 1 (EP1) signaling pathways and its'mechanistic aspects2009
- Author(s)
  Takakusagi Y., et.al.
- Organizer
  The 50th Anniversary Meeting of the American Society of Pharmacognosy
- Place of Presentation
  Honolulu, HI
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] Self-assembled monolayer (SAM) of small organic molecule for efficient random-peptide phage display selection using a cuvette type quartz-crystal microbalance (QCM) device2009
- Author(s)
  Takakusagi Y., et.al.
- Organizer
  ICCE-17
- Place of Presentation
  Honolulu, HI
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] Camptothecins : Inhibition of the E-prostanoid receptor subtype 1 (EP1) signaling pathways and its'mechanistic aspects2009
- Author(s)
  Yoichi Takakusagi et al
- Organizer
  The 50th Anniversary Meeting of the American Society of Pharmacognosy
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] Self-assembled monolayer (SAM) of small-molecule to efficiently select binding-peptide from phage library using a quartz-crystal microbalance (QCM) device2009
- Author(s)
  Yoichi Takakusagi et al
- Organizer
  ICCE-17
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] QCM-PD法で同定した医薬小分子結合ペプチド群からの医薬小分子?標的タンパク質三次元結合様式の推測2008
- Author(s)
  高草木洋一他
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] QCM装置を利用したT7ファージディスプレイ法の研究と医薬小分子結合タンパク質の同定研究2008
- Author(s)
  高草木洋一, 坂口謙吾
- Organizer
  第7回東京理科大学ゲノム創薬研究センター報告会「ゲノム創薬のフロンティアを探る」
- Place of Presentation
  東京理科大学野田キャンパス
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] キイロショウジョウバエによる医薬標的分子の評価2008
- Author(s)
  真仁田大輔、高草木洋一他
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] QCM-PD法で同定した医薬小分子結合ペプチド群からの医薬小分子標的タンパク質三次元結合様式の推測2008
- Author(s)
  高草木洋一, 他
- Organizer
  BMB2008
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] T7phagdisplay法を用いたロキシスロマイシン結合タンパク質の探索2008
- Author(s)
  鈴木愛こ、高草木洋一他
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] High-throughput and High-accuracy Drug-Target Identifications2007
- Author(s)
  Fumio Sugawara, Yoichi Takakusagi, Kouji Kuramochi
- Organizer
  The 4th Takeda Science Foundation Symposium on PharmaScience: On the Fronthiers of Chemical Biology
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] Drug-Target Identifications: (1)Affinity Purification of Proteins by Specific Ligand Immobilized on Resins, (2) T7 Phage Display Cloning of Drug-targeting Molecules2007
- Author(s)
  Fumio Sugawara, Kouji Kuramochi, Yoichi Takakusagi
- Organizer
  BIT's 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)
- Place of Presentation
  Shanghai,China
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] 低分子化合物の高性能な標的探索を可能とするファージディスプレイ法の確立2007
- Author(s)
  高草木洋一、高木真奈美、草柳友恵、真仁田大輔、倉持幸司、宮野友香、高草木香織、菅原二三男、小林進、坂口謙吾
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] T7ファージディスプレイ法を用いた抗悪性腫瘍薬イリノテカンの結合タンパク質の探索2007
- Author(s)
  小澤裕子、高草木洋一、高草木香織、小林進、坂口謙吾
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] QCM装置を利用したT7ファージディスプレイ法の改良および医薬小分子結合タンパク質の同定研究2007
- Author(s)
  高草木洋一
- Organizer
  第1回QCM研究会セミナー
- Place of Presentation
  ホテルパシフィック東京(品川)
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19750145
[Presentation] Drug-Target Identifications: (1)Affinity Purification of Proteins by Specific Ligand Immobilized on Resins, (2)T7 Phage Display Cloning of Drug-targeting Molecules2007
- Author(s)
  菅原二三男、倉持幸司、高草木洋一
- Organizer
  BIT's 5th Anniversary Congress of International Drug Discovery Science and Technology (IDDST)
- Place of Presentation
  Shanghai, China
- Year and Date
  2007-05-28
- Data Source
  KAKENHI-PROJECT-19750145

1. 大嶋野歩 (70571454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 兵藤文紀 (10380693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. MATSUO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 市川和洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 齋藤雄太朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 山東信介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takakusagi Yoichi 高草木 洋一

TAKAKUSAGI Yoichi 高草木 洋一

Research Projects

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Co-Researchers

Innovation of cancer chemoradiotherapy based on hyperpolarized-nuclear magnetic resonance metabolic imagingPrincipal Investigator

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Establishment of Non-clinical POC using hyperpolarized MRI and 3D cultured cancer tissue for personalized medicine of metabolic inhibitor therapy.

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Study for next-generation precision medicine based on the highly targeted theranostics for the pathological neovascularization of cancersPrincipal Investigator

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A model study for personalized cancer medicine by the novel chemoradiotherapy guided on the state-of-the-art spin resonance imagingPrincipal Investigator

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Monitoring of the hemoglobin oxygen saturation via the ultra-high sensitive NMR signalsPrincipal Investigator

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Validation of protein-drug interactions identified by the phage display technologyPrincipal Investigator

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[Book] 「蛋白質核酸酵素」7月号新実験講座2009

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[Book] 蛋白質核酸酵素7月号新実験講座2009

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[Journal Article] Novel Structure-guided Design of Amino Acid Based Hyperpolarized 13C Probes for Metabolic Imaging2023

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[Journal Article] Hypersensitive MR Metabolic Imaging Realized by Means of Dynamic Nuclear Polarization (DNP)2023

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[Journal Article] EPR and Related Magnetic Resonance Imaging Techniques in Cancer Research2023

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[Journal Article] Design and Development of the Molecular Probes for Application of the Hyperpolarized-NMR/MRI2022

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[Journal Article] Structure-based relaxation analysis reveals C-terminal [1-13C]glycine-d2 in peptides has long spin-lattice relaxation time that is applicable to in vivo hyperpolarized magnetic resonance studies2022

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[Journal Article] Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging2022

Author(s)

Takakusagi Yoichi 高草木洋一

TAKAKUSAGI Yoichi 高草木洋一