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Uematsu Ken  上松 謙

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上松 謙  ウエマツ ケン

UEMATSU Ken  上松 謙

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Researcher Number 60441672
Affiliation (Current) 2025: 久留米大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help 2019: 久留米大学, 医学部, 非常勤講師
2017 – 2018: 久留米大学, 高次脳疾患研究所, 講師
2016: 久留米大学, 高次脳疾患研究所, 助教
2010 – 2014: 久留米大学, 高次脳疾患研究所, 助教
2011: 久留米大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Psychiatric science
Keywords
Principal Investigator
統合失調症 / 精神薬理学 / ドーパミンD1シグナル / フィンゴリモド塩酸塩 / 薬物乱用・薬物依存 / スフィンゴシン-1-リン酸受容体 / スフィンゴシン-1-リン酸 / フィンゴリモド塩酸塩(FTY720) / ドーパミンD1シグナル / FTY720 … More / S1Pレセプター / コカイン / カンナビノイド受容体 / グルタミン酸受容体 / 神経科学 / 細胞内カルシウム / プロテインキナーゼA / 代謝型グルタミン酸受容体5 / 細胞内カルシウム動態 / 蛋白リン酸化修飾 / 細胞内情報伝達 / 分子生物学 Less
  • Research Projects

    (3 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (2 People)
  •  Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signalPrincipal Investigator

    • Principal Investigator
      Uematsu Ken
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Pathogenesis of schizophrenia negative symptoms that focuses on the glutamate receptors and cannabinoid receptorPrincipal Investigator

    • Principal Investigator
      UEMATSU Ken
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University
  •  Investigation of the mechanism of metabotropic glutamate receptor 5 activity which protein related to psychiatric disorder.Principal Investigator

    • Principal Investigator
      UEMATSU Ken
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Kurume University

All 2018 2017 2016 2015 2011 Other

All Journal Article Presentation

  • [Journal Article] プロテインキナーゼAは代謝型グルタミン酸受容体5を直接リン酸化修飾してその機能が制御される2016

    • Author(s)
      上松 謙
    • Journal Title

      九州神経精神医学

      Volume: 62 Pages: 96-102

    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Journal Article] Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function2015

    • Author(s)
      Ken Uematsu, Myriam Heiman, Marina Zelenina, Júlio Padovan, Brian T. Chait, Anita Aperia, Akinori Nishi, and Paul Greengard
    • Journal Title

      Journal of Neurochemistry

      Volume: 132 Issue: 6 Pages: 677-686

    • DOI

      10.1111/jnc.13038

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24791245
  • [Presentation] Fingolimod (FTY720) suppress cocaine-induced hyper locomotion, which attenuate striatal D1-type medium spiny neurons of PKA/DARPP-32 signaling.2018

    • Author(s)
      Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Society for Neuroscience
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Fingolomod attenuate cocaine induced locomotor activity by decreasing PKA/DARPP32 signaling in striatal D1-type medium spiny neurons.2017

    • Author(s)
      Ken Uematsu, Takahide Shuto, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Neuro Science 2017 ( Washington, DC)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Fingolimod attenuates cocaine-induced locomotor activities in vivo by decreasing PKA/DARPP-32 signaling in striatal D1-type medium spiny neurons.(フィンゴリモドは線条体のドーパミンD1タイプ線条体中型有棘神経細胞でPKA/DARPP-32シグナルを抑制してコカインによる過活動性を減弱させる)2017

    • Author(s)
      上松 謙、首藤 隆秀、小路 純央、内村 直尚、西 昭徳
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Sphingosine-1-phosphate (S1P) and fingolimod regulate PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms.2016

    • Author(s)
      Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
    • Organizer
      Neuro Science 2016
    • Place of Presentation
      Sandiego convention center
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] Fingolomod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms (フィンゴリモドはスフィンゴシン-1-リン酸受容体を介して線条体中型有棘細胞のPKA/DARPP-32シグナル伝達を制御する)2016

    • Author(s)
      上松 謙、花田 雄樹、首藤 隆秀、小路 純央、内村 直尚、西 昭徳
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-16K10197
  • [Presentation] スフィンゴシン-1-リン酸による線条体中型有棘細胞でのGPR6ひ依存性のPKA/DARPP-32シグナル伝達の解析2011

    • Author(s)
      上松謙, 内村直尚, 松石豊次郎, 西昭徳
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-22791149
  • [Presentation] Fingolimod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal sphingosine-1-phosphate receptor mechanisms.

    • Author(s)
      Ken Uematsu, Kiichiro Morita, Naohisa Uchimura, Akinori Nishi
    • Organizer
      日本神経科学会大会
    • Place of Presentation
      神奈川県横浜市西区みなとみらい1-1-1 パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Data Source
      KAKENHI-PROJECT-24791245
  • 1.  西 昭徳 (50228144)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  首藤 隆秀 (70412541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results

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