Uematsu Ken 上松謙

… Alternative Names

上松謙ウエマツケン

UEMATSU Ken 上松謙

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Researcher Number	60441672
Affiliation (Current)	2025: 久留米大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2019: 久留米大学, 医学部, 非常勤講師 2017 – 2018: 久留米大学, 高次脳疾患研究所, 講師 2016: 久留米大学, 高次脳疾患研究所, 助教 2010 – 2014: 久留米大学, 高次脳疾患研究所, 助教 2011: 久留米大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Psychiatric science
Keywords	Principal Investigator 統合失調症 / 精神薬理学 / ドーパミンＤ１シグナル / フィンゴリモド塩酸塩 / 薬物乱用・薬物依存 / スフィンゴシン-1-リン酸受容体 / スフィンゴシン-1-リン酸 / フィンゴリモド塩酸塩（FTY720) / ドーパミンD1シグナル / FTY720 … More / S1Pレセプター / コカイン / カンナビノイド受容体 / グルタミン酸受容体 / 神経科学 / 細胞内カルシウム / プロテインキナーゼA / 代謝型グルタミン酸受容体5 / 細胞内カルシウム動態 / 蛋白リン酸化修飾 / 細胞内情報伝達 / 分子生物学 Less

Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signalPrincipal Investigator
- Principal Investigator
  
  Uematsu Ken
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Pathogenesis of schizophrenia negative symptoms that focuses on the glutamate receptors and cannabinoid receptorPrincipal Investigator
- Principal Investigator
  
  UEMATSU Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University
Investigation of the mechanism of metabotropic glutamate receptor 5 activity which protein related to psychiatric disorder.Principal Investigator
- Principal Investigator
  
  UEMATSU Ken
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Kurume University

All 2018 2017 2016 2015 2011 Other

All Journal Article Presentation

[Journal Article] プロテインキナーゼAは代謝型グルタミン酸受容体５を直接リン酸化修飾してその機能が制御される2016
- Author(s)
  上松　謙
- Journal Title
  
  九州神経精神医学
  
  Volume: 62 Pages: 96-102
- Data Source
  KAKENHI-PROJECT-16K10197
[Journal Article] Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function2015
- Author(s)
  Ken Uematsu, Myriam Heiman, Marina Zelenina, Júlio Padovan, Brian T. Chait, Anita Aperia, Akinori Nishi, and Paul Greengard
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 132 Issue: 6 Pages: 677-686
- DOI
  10.1111/jnc.13038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791245
[Presentation] Fingolimod (FTY720) suppress cocaine-induced hyper locomotion, which attenuate striatal D1-type medium spiny neurons of PKA/DARPP-32 signaling.2018
- Author(s)
  Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
- Organizer
  Society for Neuroscience
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Fingolomod attenuate cocaine induced locomotor activity by decreasing PKA/DARPP32 signaling in striatal D1-type medium spiny neurons.2017
- Author(s)
  Ken Uematsu, Takahide Shuto, Naohisa Uchimura, Akinori Nishi
- Organizer
  Neuro Science 2017 ( Washington, DC)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Fingolimod attenuates cocaine-induced locomotor activities in vivo by decreasing PKA/DARPP-32 signaling in striatal D1-type medium spiny neurons.（フィンゴリモドは線条体のドーパミンD1タイプ線条体中型有棘神経細胞でPKA/DARPP-32シグナルを抑制してコカインによる過活動性を減弱させる）2017
- Author(s)
  上松　謙、首藤　隆秀、小路　純央、内村　直尚、西　昭徳
- Organizer
  第９０回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Sphingosine-1-phosphate (S1P) and fingolimod regulate PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms.2016
- Author(s)
  Ken Uematsu, Takahide Shuto, Yoshihisa Syoji, Naohisa Uchimura, Akinori Nishi
- Organizer
  Neuro Science 2016
- Place of Presentation
  Sandiego convention center
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] Fingolomod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms （フィンゴリモドはスフィンゴシン－１－リン酸受容体を介して線条体中型有棘細胞のPKA/DARPP-32シグナル伝達を制御する）2016
- Author(s)
  上松　謙、花田　雄樹、首藤　隆秀、小路　純央、内村　直尚、西　昭徳
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K10197
[Presentation] スフィンゴシン-1-リン酸による線条体中型有棘細胞でのGPR6ひ依存性のPKA/DARPP-32シグナル伝達の解析2011
- Author(s)
  上松謙, 内村直尚, 松石豊次郎, 西昭徳
- Organizer
  日本神経科学会
- Place of Presentation
  横浜
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22791149
[Presentation] Fingolimod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal sphingosine-1-phosphate receptor mechanisms.
- Author(s)
  Ken Uematsu, Kiichiro Morita, Naohisa Uchimura, Akinori Nishi
- Organizer
  日本神経科学会大会
- Place of Presentation
  神奈川県横浜市西区みなとみらい１－１－１　パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24791245

1. 西昭徳 (50228144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 首藤隆秀 (70412541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Uematsu Ken 上松 謙

上松 謙 ウエマツ ケン

UEMATSU Ken 上松 謙

Research Projects

Research Products

Co-Researchers

Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of schizophrenia negative symptoms that focuses on the glutamate receptors and cannabinoid receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of metabotropic glutamate receptor 5 activity which protein related to psychiatric disorder.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] プロテインキナーゼAは代謝型グルタミン酸受容体５を直接リン酸化修飾してその機能が制御される2016

Author(s)

Journal Title

Data Source

[Journal Article] Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Fingolimod (FTY720) suppress cocaine-induced hyper locomotion, which attenuate striatal D1-type medium spiny neurons of PKA/DARPP-32 signaling.2018

Author(s)

Organizer

Data Source

[Presentation] Fingolomod attenuate cocaine induced locomotor activity by decreasing PKA/DARPP32 signaling in striatal D1-type medium spiny neurons.2017

Author(s)

Organizer

Data Source

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Sphingosine-1-phosphate (S1P) and fingolimod regulate PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Fingolomod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal S1P receptor mechanisms （フィンゴリモドはスフィンゴシン－１－リン酸受容体を介して線条体中型有棘細胞のPKA/DARPP-32シグナル伝達を制御する）2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] スフィンゴシン-1-リン酸による線条体中型有棘細胞でのGPR6ひ依存性のPKA/DARPP-32シグナル伝達の解析2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Fingolimod regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via neuronal sphingosine-1-phosphate receptor mechanisms.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Uematsu Ken 上松謙

上松謙ウエマツケン

UEMATSU Ken 上松謙