Maeta Kazuhiro 前田和宏

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MAETA Kazuhiro 前田和宏

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Researcher Number	60443024
Other IDs
Affiliation (Current)	2026: 神戸学院大学, 総合リハビリテーション学部, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 神戸学院大学, 総合リハビリテーション学部, 研究員 2008: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 基礎科学特別研究員 2007: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Applied molecular and cellular biology
Keywords	Principal Investigator スプライシング / アポトーシス / アンチセンス核酸 / ミオスタチン / 横紋筋肉腫 / プロテオミクス / 翻訳後修飾 / メチル化 / アセチル化 / ヒストンH4 … More / ヒストンH3 / シグナル伝達 / ヒストン / 分裂酵母 / リバースアレイ / リバースプロテオミクス / タンパク質翻訳後修飾 Less

Myostatin antisense nucleic acid therapy for rhabdomyosarcomaPrincipal Investigator
- Principal Investigator
  
  Maeta Kazuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kobe Gakuin University
Reverse array analysis for post-translational modification of histonesPrincipal Investigator
- Principal Investigator
  
  MAETA Kazuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2009 2007

All Journal Article Presentation Patent

[Journal Article] Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration2024
- Author(s)
  Mamiko Yamada, Kazuhiro Maeta, Hisato Suzuki, Ryo Kurosawa, Toshiki Takenouchi, Tomonari Awaya , Masahiko Ajiro , Atsuko Takeuchi, Hisahide Nishio , Masatoshi Hagiwara , Fuyuki Miya, Masafumi Matsuo, Kenjiro Kosaki
- Journal Title
  
  Sci Rep .
  
  Volume: - Issue: 1 Pages: 6506-6506
- DOI
  10.1038/s41598-024-56704-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15873, KAKENHI-PROJECT-22KJ2023, KAKENHI-PROJECT-21K07762, KAKENHI-PROJECT-23K27379
[Journal Article] A novel splice variant of the human <i>MSTN</i> gene encodes a myostatin‐specific myostatin inhibitor2023
- Author(s)
  Maeta Kazuhiro、Farea Manal、Nishio Hisahide、Matsuo Masafumi
- Journal Title
  
  Journal of Cachexia, Sarcopenia and Muscle
  
  Volume: 14 Issue: 5 Pages: 2289-2300
- DOI
  10.1002/jcsm.13314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07762
[Journal Article] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.2023
- Author(s)
  Takeuchi T., Maeta K., Xin D., Oe Y., Takeda A., Inoue M., Nagano S., Fujihara T., Matsuda S., Ishigaki S., Sahashi K., Minakawa E.N., Mochizuki H., Neya M., Sobue G., *Nagai Y.
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume: 31 Pages: 353-366
- DOI
  10.1016/j.omtn.2023.01.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K18265, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811, KAKENHI-PROJECT-21K07762, KAKENHI-PROJECT-23K21410, KAKENHI-PROJECT-23K24054
[Journal Article] A case of infantile Barth syndrome with severe heart failure: Importance of splicing variants in the TAZ gene2023
- Author(s)
  Takeda A, Ueki M, Abe J, Maeta K, Horiguchi T, Yamazawa H, Izumi G, Chida-Nagai A, Sasaki D, Tsujioka T, Sato I, Shiraishi M, Matsuo M.
- Journal Title
  
  Mol Genet Genomic Med.
  
  Volume: 11 Issue: 7
- DOI
  10.1002/mgg3.2190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07496, KAKENHI-PROJECT-21K07762
[Journal Article] An Antisense Oligonucleotide against a Splicing Enhancer Sequence within Exon 1 of the MSTN Gene Inhibits Pre-mRNA Maturation to Act as a Novel Myostatin Inhibitor2022
- Author(s)
  Maeta Kazuhiro、Farea Manal、Nishio Hisahide、Matsuo Masafumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5016-5016
- DOI
  10.3390/ijms23095016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07762
[Journal Article] Human dystrophin Dp71ab enhances the proliferation of myoblasts across species but not human nonmyoblast cells.2022
- Author(s)
  Farea M, Maeta K, Nishio H, and Matsuo M
- Journal Title
  
  Front Cell Dev Biol
  
  Volume: 10 Pages: 877612-877612
- DOI
  10.3389/fcell.2022.877612
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07875, KAKENHI-PROJECT-21K07762
[Patent] ミオスタチンスプライスバリアント由来タンパク質によるミオスタチンシグナル阻害とその利用2021
- Inventor(s)
  松尾雅文、岡崎宏亮、前田和宏
- Industrial Property Rights Holder
  神戸天然物化学株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] MSTN遺伝子のスプライシングをスイッチするアンチセンス核酸はデュシェンヌ型筋ジストロフィーモデルマウスの所見を改善する2023
- Author(s)
  前田和宏、竹内敦子、西尾久英、松尾雅文
- Organizer
  第9回日本筋学会学術集会、第10回筋ジストロフィー医療研究会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] スプライシング開始阻害型アンチセンス核酸の開発：MSTN遺伝子をモデルとして2022
- Author(s)
  前田和宏、Manal Farea、岡本到、藤原健志、閨正博、西尾久英、松尾雅文
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] N-of-1アンチセンス核酸薬の開発システムの構築2022
- Author(s)
  松尾雅文、前田和宏、西尾久英
- Organizer
  第125回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ジストロフィンDp71abは筋芽細胞の増殖を特異的に促進する2022
- Author(s)
  松尾雅文、Manal Farea、前田和宏、西尾久英
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] MSTN遺伝子のスプライシングバリアントの産生を促すアンチセンス核酸2022
- Author(s)
  前田和宏、Manal Farea、西尾久英、松尾雅文
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ヒトのミオスタチンアイソフォームはミオスタチンを阻害し筋芽細胞の増殖を促進する2022
- Author(s)
  前田和宏、Manal Farea、西尾久英、松尾雅文
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ヒトMSTN遺伝子で初めてクローニングしたスプライシングバリアントは3’UTR内の非典型スプライスサイトを活性化していた2022
- Author(s)
  前田和宏、Manal Farea、西尾久英、松尾雅文
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] A splicing variant found in the human myostatin gene encodes an isoform that inhibits myostatin2022
- Author(s)
  Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo
- Organizer
  American Society of Human Genetics Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ACE2遺伝子のエクソンスキッピングを誘導するアンチセンス核酸2022
- Author(s)
  前田和宏、Manal Farea、岡本到、藤原健志、閨正博、西尾久英、松尾雅文
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] ミオスタチン新規アイソフォームはミオスタチンを特異的に阻害し筋芽細胞増殖を促進する2021
- Author(s)
  前田和宏、Manal Farea、西尾久英、松尾雅文
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07762
[Presentation] 分裂酵母遺伝子過剰発現コレクションを用いたヒストン翻訳後修飾を引き起す上流因子のリバースアレイ解析2009
- Author(s)
  前田和宏
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19780253
[Presentation] Reverse array analysis for understanding signaling pathways2007
- Author(s)
  前田和宏、松山晃久、白井温子、橋本敦、河村優美、吉田稔
- Organizer
  Fourth International Fission Yeast Meeting
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-19780253
[Presentation] Reverse array analysis for understanding signaling pathways2007
- Author(s)
  前田和宏
- Organizer
  Fourth International Fission Yeast Meeting
- Place of Presentation
  Copenhagen, Demmark
- Data Source
  KAKENHI-PROJECT-19780253

1. 西村範行 (00322719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 松尾雅文 (10157266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. 山田茉未子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 永井義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 佐々木大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 武田充人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maeta Kazuhiro 前田 和宏

MAETA Kazuhiro 前田 和宏

Research Projects

Research Products

Co-Researchers

Myostatin antisense nucleic acid therapy for rhabdomyosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reverse array analysis for post-translational modification of histonesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel splice variant of the human <i>MSTN</i> gene encodes a myostatin‐specific myostatin inhibitor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of infantile Barth syndrome with severe heart failure: Importance of splicing variants in the TAZ gene2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Antisense Oligonucleotide against a Splicing Enhancer Sequence within Exon 1 of the MSTN Gene Inhibits Pre-mRNA Maturation to Act as a Novel Myostatin Inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human dystrophin Dp71ab enhances the proliferation of myoblasts across species but not human nonmyoblast cells.2022

Author(s)

Journal Title

DOI

Data Source

[Patent] ミオスタチンスプライスバリアント由来タンパク質によるミオスタチンシグナル阻害とその利用2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] MSTN遺伝子のスプライシングをスイッチするアンチセンス核酸はデュシェンヌ型筋ジストロフィーモデルマウスの所見を改善する2023

Author(s)

Organizer

Data Source

[Presentation] スプライシング開始阻害型アンチセンス核酸の開発：MSTN遺伝子をモデルとして2022

Author(s)

Organizer

Data Source

[Presentation] N-of-1アンチセンス核酸薬の開発システムの構築2022

Author(s)

Organizer

Data Source

[Presentation] ジストロフィンDp71abは筋芽細胞の増殖を特異的に促進する2022

Author(s)

Organizer

Data Source

[Presentation] MSTN遺伝子のスプライシングバリアントの産生を促すアンチセンス核酸2022

Author(s)

Organizer

Data Source

[Presentation] ヒトのミオスタチンアイソフォームはミオスタチンを阻害し筋芽細胞の増殖を促進する2022

Author(s)

Organizer

Data Source

[Presentation] ヒトMSTN遺伝子で初めてクローニングしたスプライシングバリアントは3’UTR内の非典型スプライスサイトを活性化していた2022

Author(s)

Maeta Kazuhiro 前田和宏

MAETA Kazuhiro 前田和宏