Huang Mingguo 黄明国

… Alternative Names

HUANG Mingguo 黄明国

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Researcher Number	60448503
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 特別研究員
Affiliation (based on the past Project Information) *help	2024: 秋田大学, 医学系研究科, 非常勤講師 2018: 秋田大学, 医学系研究科, 助教 2013 – 2017: 秋田大学, 医学(系)研究科(研究院), 助教 2015: 秋田大学, 医学部, 助教 2012: 秋田大学, 学内共同利用施設等, 助教 … More 2011: 秋田大学, 医学研究科, 特任助教 2011: 秋田大学, 大学院・医学系研究科, 助教 2010: 秋田大学, 医学系研究科, 特任助教 Less
Review Section/Research Field	Principal Investigator Urology / Basic Section 56030:Urology-related Except Principal Investigator Urology
Keywords	Principal Investigator 前立腺癌 / TRAMP mice / Cancer Metabolism / FABP4 / high fat diet / FASN / 前立腺がん / MIC-1 / palmitic acid / high-fat diet … More / prostate cancer / Fn14 / TWEAK / 腫瘍学 … More Except Principal Investigator 前立腺癌 / バイオマーカー / エクソソーム / 腎細胞癌 / 分子標的薬 / microRNA / ステロイドホルモン受容体 / 抗癌剤耐性 / Hippo経路 / プロゲステロン受容体 / アンドロゲン受容体 / 化学療法 / 生化学的再発 / ステロイド受容体 / 血中濃度 / 薬力学 / トランスクリプトミクス / ファーマコゲノミクス / サイトカイン / マイクロRNA / 遺伝子多型 / 薬物動態 / RNA / DNA / Liquid Biopsy / 泌尿器癌 / miRNA / アキシチニブ / 尿路上皮癌 / miR-21 / PAI-1 / 液性生検 / エキソソーム / 膀胱癌 / 腎癌 / miR-130a / MET / 高脂肪食 Less

The role of FABP4 on HFD-mediated prostate tumor progression in TRAMP micePrincipal Investigator
- Principal Investigator
  
  黄明国
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Akita University
The impact of steroid receptors in chemohormone resistant prostate cancer
- Principal Investigator
  
  Narita Shintaro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University
Establishment of novel therapeutic system for renal cell carcinoma by pahrmacogenomics and transcriptomics
- Principal Investigator
  
  Tsuchiya Norihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yamagata University
Identification of factors associated with drug-therapy resistance by pheripheral blood serum cell-free nucleotic acids
- Principal Investigator
  
  Habuchi Tomonori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Akita University
Impact of microRNAs on high-fat diet induced prostate cancer progression
- Principal Investigator
  
  Narita Shintaro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University
Diet-induced macrophage inhibitory cytokine 1 and prostate cancer progression.Principal Investigator
- Principal Investigator
  
  HUANG Mingguo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Akita University
Role of TWEAK-Fn14 signaling under high-fat diet or obesity on prostate cancer progressionPrincipal Investigator
- Principal Investigator
  
  HUANG Mingguo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Akita University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Incidence and location of positive surgical margin among open, laparoscopic and robot-assisted radical prostatectomy in prostate cancer patients: a single institutional analysis2018
- Author(s)
  Koizumi A, Narita S, Nara T, Takayama K, Kanda S, Numakura K, Tsuruta H, Maeno A, Huang M, Saito M, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Habuchi T.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 48 Issue: 8 Pages: 765-770
- DOI
  10.1093/jjco/hyy092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10992
[Journal Article] Inverse relationship between insulin receptor expression and progression in renal cell carcinoma.2017
- Author(s)
  Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Habuchi T.
- Journal Title
  
  Oncol Rep.
  
  Volume: 37 Issue: 5 Pages: 2929-2941
- DOI
  10.3892/or.2017.5552
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H02679, KAKENHI-PROJECT-15K10573
[Journal Article] Inhibition of the RANK/RANKL signaling with osteoprotegerin prevents castration-induced acceleration of bone metastasis in castration-insensitive prostate cancer2017
- Author(s)
  1)Takayama K, Inoue T, Narita S, Maita S, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Satoh S, Tsuchiya N, Habuchi T
- Journal Title
  
  Cancer Letters
  
  Volume: in press Pages: 103-110
- DOI
  10.1016/j.canlet.2017.03.034
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-16H02679
[Journal Article] The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the "obesity paradox".2017
- Author(s)
  Ito R, Narita S, Huang M, Nara T, Numakura K, Takayama K, Tsuruta H, Maeno A, Saito M, Inoue T, Tsuchiya N, Satoh S, Habuchi T
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 2 Pages: e0171615-e0171615
- DOI
  10.1371/journal.pone.0171615
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02679, KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-16K10992
[Journal Article] Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib2017
- Author(s)
  Numakura K, Tsuchiya N, Kagaya H, Takahashi M, Tsuruta H, Inoue T, Narita S, Huang M, Satoh S, Niioka T, Miura M, Habuchi T
- Journal Title
  
  Anticancer Drugs
  
  Volume: 28 Issue: 1 Pages: 97-103
- DOI
  10.1097/cad.0000000000000425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10573
[Journal Article] Diet-induced alteration of fatty acid synthase in prostate cancer progression2016
- Author(s)
  Huang M, Koizumi A, Narita S, Inoue T, Tsuchiya N, Nakanishi H, Numakura K, Tsuruta H, Saito M, Satoh S, Nanjo H, Sasaki T, Habuchi T
- Journal Title
  
  Oncogenesis
  
  Volume: ５ Issue: 2 Pages: e195-e195
- DOI
  10.1038/oncsis.2015.42
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-25462466, KAKENHI-PROJECT-25293332
[Journal Article] Effects of functional genetic polymorphisms in the CYP19A1 gene on prostate cancer risk and survival2015
- Author(s)
  Kanda S, Tsuchiya N, Narita S, et al.
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Issue: 1 Pages: 74-82
- DOI
  10.1002/ijc.28952
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592373, KAKENHI-PROJECT-25220206, KAKENHI-PROJECT-25293332, KAKENHI-PROJECT-26670695
[Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor.2015
- Author(s)
  Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
- Journal Title
  
  Cancer Discovery
  
  Volume: in press Issue: 7 Pages: 730-9
- DOI
  10.1158/2159-8290.cd-14-1329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26461458, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-15K18857, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-26860686, KAKENHI-PROJECT-25293332
[Journal Article] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression2014
- Author(s)
  Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
- Journal Title
  
  Endocr Relat Cancer
  
  Volume: 21 Issue: 1 Pages: 39-50
- DOI
  10.1530/erc-13-0227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592374, KAKENHI-PROJECT-25293332
[Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activatesMCP-1/CCR2 signaling2012
- Author(s)
  Mingguo Huang, Shintaro Narita, Kazuyuki Numakura, Hiroshi Tsuruta, Mitsuru Saito, Takamitsu Inoue, Yohei Horikawa, Norihiko Tsuchiya and Tomonori Habuchi
- Journal Title
  
  The Prostate
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22791464
[Journal Article] Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011
- Author(s)
  Mingguo Huang, Shintaro Narita, Norihiko Tsuchiya, Zhiyong Ma, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Mitsuru Saito, Takamitsu Inoue, Yohei Horikawa, Shigeru Satoh and Tomonori Habuchi
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(11) Pages: 1589-96
- Data Source
  KAKENHI-PROJECT-22791464
[Journal Article] Overexpression of Fn14 Promotes Androgen Independent Prostate Cancer Progression through MMP-9 and Correlates with Poor Treatment Outcome2011
- Author(s)
  Huang M, Narita S, Tsuchiya N, et al.
- Journal Title
  
  Carcinogenesis
  
  Volume: (Epub) Issue: 11 Pages: 1589-96
- DOI
  10.1093/carcin/bgr182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592029, KAKENHI-PROJECT-22791464
[Presentation] Tissue biomarkers in patients with high-risk prostate cancer treated with neoadjuvant chemohormonal therapy.2018
- Author(s)
  Narita. S., Nara. T., Chiba. S., Kanda. S., Numakura. K., Saito. M., Inoue. T., Huang. M., Nanjo. H., Habuchi. T.
- Organizer
  第77回日本癌学会総会, 9月, 大阪
- Data Source
  KAKENHI-PROJECT-16K10992
[Presentation] ハイリスク前立腺癌に対する術前化学内分泌療法併用前立腺全摘の治療成績と組織バイオマーカーの探索2017
- Author(s)
  成田伸太郎, 奈良健平、高山孝一朗、黄明国、鶴田大、沼倉一幸、前野淳、齋藤満、井上高光、南條博、羽渕友則.
- Organizer
  第105回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-16K10992
[Presentation] Impact of Hippo pathway protein expression in residual cancer after neoadjuvant chemohormonal therapy with docetaxel for high-risk localized prostate cancer.2017
- Author(s)
  Narita, S., Nara, T., Huang, M., Numakura, K., Tsuruta, H., Maeno, A., Saito, M., Inoue, T., Satoh, S., Habuchi, T.
- Organizer
  The 112th Annual Meeting of the American Urological Association, May, Boston, USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10992
[Presentation] MiR-130a modulates high-fat diet-induced prostate cancer progression through the activation of MET2016
- Author(s)
  Taketoshi Nara, Shintaro Narita, Huang Mingguo, Toshiaki Yoshioka, Koichiro Takayama, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Shigeru Satoh, Tomonori Habuchi
- Organizer
  Annual Meeting of American Urological Association 2016
- Place of Presentation
  SanDiego, California, USA
- Year and Date
  2016-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670695
[Presentation] Expression of steroid hormone receptors in residual cancer and stromal cells after neoadjuvant chemohormonal therapy with docetaxal for high-risk localized prostate cancer.2016
- Author(s)
  Narita, S., Nara, T., Huang, M., Numakura, K., Tsuruta, H., Maeno, A., Saito,M., Inoue, T., Tsuchiya, N., Nanjo, H., Satoh,S., Habuchi, T.
- Organizer
  The 111th annual meeting of the American Urological Association
- Place of Presentation
  San diego
- Year and Date
  2016-05-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10992
[Presentation] Expression of steroid hormone receptors in residual cancer and stromal cells after neoadjuvant chemohormonal therapy with docetaxal for high-risk localized prostate cancer2016
- Author(s)
  Shintaro Narita, Taketoshi Nara, Mingguo Huang, Koichiro Takayama, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Hiroshi Nanjo, Shigeru Satoh, Tomonori Habuchi
- Organizer
  Annual Meeting of American Urological Association 2016
- Place of Presentation
  SanDiego, California, USA
- Year and Date
  2016-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670695
[Presentation] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression2013
- Author(s)
  Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592374
[Presentation] Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression2013
- Author(s)
  Huang M, Narita S, Inoue T, Tsuchiya N, Satoh S, Nanjo H, Sasaki T, Habuchi T.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24592374
[Presentation] 長鎖脂肪酸パルミチンによる前立腺癌進展の機序解明2012
- Author(s)
  黄明国、
- Organizer
  第71回日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592374
[Presentation] 長鎖脂肪酸パルミチンによる前立腺癌進展の機序解明2012
- Author(s)
  黄明国、
- Organizer
  第100回日本泌尿器科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24592374
[Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011
- Author(s)
  Mingguo Huang, Shintaro Narita, Kazuyuki Numakura, Hiroshi Tsuruta, Mitsuru Saito, Takamitsu Inoue, Yohei Horikawa, Norihiko Tsuchiya and Tomonori Habuchi
- Organizer
  2011年アメリカ泌尿器科学会で発表
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] A high-fat diet enhances prostate cancer growth by MCP-1/CCR2 signaling2011
- Author(s)
  Huang M, et al.
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] A high-fat diet enhances prostate cancer growth by MCP-1/CCR2 signaling2011
- Author(s)
  Mingguo Huang, Shintaro Narita, Kazuyuki Numakura, Hiroshi Tsuruta, Mitsuru Saito, Takamitsu Inoue, Yohei Horikawa, Norihiko Tsuchiya and Tomonori Habuchi
- Organizer
  2011年日本癌学会で発表
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] A high-fat diet enhances prostate cancer growth by MCP-1/CCR2 signaling2011
- Author(s)
  Huang M, et al.
- Organizer
  2011年度アメリカ泌尿器科学会
- Place of Presentation
  ワシントン
- Year and Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] TWEAK-Fn14 signaling regulates androgen independent prostate cancer cell invasiveness and correlates with poor patient outcome2010
- Author(s)
  黄明国
- Organizer
  アメリカ泌尿器科学会
- Place of Presentation
  San Francisco, Moscone North(米国)
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] TWEAKI-Fn14シグナルはホルモン不応性前立腺癌の浸潤を制御し、患者の予後に関連する2010
- Author(s)
  黄明国
- Organizer
  日本癌学会
- Place of Presentation
  Osaka International Convention Center
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22791464
[Presentation] High-fat diet alters phosphatidylinositol profile and tumor growth in the LNCaP xenograft mice
- Author(s)
  小泉淳、黄明国、成田伸太郎，井上高光，土谷順彦，佐藤滋，羽渕友則
- Organizer
  第73回日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24592374
[Presentation] 高脂肪食下前立腺がん進展におけるFASNの役割
- Author(s)
  黄明国、成田伸太郎，井上高光，土谷順彦，佐藤滋，羽渕友則
- Organizer
  第102回日本泌尿器科学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24592374

1. NARITA Shintaro (40396552)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. TSUCHIYA Norihiko (70282176)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. INOUE Takamitsu (60375243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 南條博 (70250892)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Habuchi Tomonori (00293861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 大山力 (80282135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤山信弘 (90603275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. EGUCHI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NAKANISHI Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 沼倉一幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 佐々木雄彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高須賀俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Huang Mingguo 黄 明国

HUANG Mingguo 黄 明国

Research Projects

Research Products

Co-Researchers

The role of FABP4 on HFD-mediated prostate tumor progression in TRAMP micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The impact of steroid receptors in chemohormone resistant prostate cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel therapeutic system for renal cell carcinoma by pahrmacogenomics and transcriptomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of factors associated with drug-therapy resistance by pheripheral blood serum cell-free nucleotic acids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impact of microRNAs on high-fat diet induced prostate cancer progression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Diet-induced macrophage inhibitory cytokine 1 and prostate cancer progression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of TWEAK-Fn14 signaling under high-fat diet or obesity on prostate cancer progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Incidence and location of positive surgical margin among open, laparoscopic and robot-assisted radical prostatectomy in prostate cancer patients: a single institutional analysis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inverse relationship between insulin receptor expression and progression in renal cell carcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of the RANK/RANKL signaling with osteoprotegerin prevents castration-induced acceleration of bone metastasis in castration-insensitive prostate cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the "obesity paradox".2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diet-induced alteration of fatty acid synthase in prostate cancer progression2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of functional genetic polymorphisms in the CYP19A1 gene on prostate cancer risk and survival2015

Author(s)

Journal Title

Huang Mingguo 黄明国

HUANG Mingguo 黄明国