Tokuhara Daisuke 徳原大介

… Alternative Names

徳原大介トクハラダイスケ

TOKUHARA Daisuke 徳原大介

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Researcher Number	60448751
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 和歌山県立医科大学, 医学部, 教授 2022: 和歌山県立医科大学, 医学部, 教授 2015 – 2018: 大阪市立大学, 大学院医学研究科, 講師 2017: 大阪市立大学, 医学(系)研究科(研究院), 講師 2014: 大阪市立大学, 医学(系)研究科, 講師 2012 – 2014: 大阪市立大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Embryonic/Neonatal medicine / Pediatrics
Keywords	Principal Investigator アジュバント / 小児 / ワクチン / 感染症 / 自然免疫 / ノロウイルス / Toll様受容体 / 免疫学 / 臍帯血 / 樹状細胞 … More / 粘膜ワクチン / 分泌型IgA抗体 / zymosan / 抗原提示細胞 / 新生児 / ムコ多糖症 / Toll-様受容体 / 免疫 / サイトカイン / 単球 / ドラッグデリバリーシステム / 経鼻免疫 / 舌下免疫 / ロタウイルス … More Except Principal Investigator 感染症 / 臍帯血 / ウイルス / RSウイルス / 自然免疫 / 新生児 / アジュバント / ワクチン / トランスジェニックマウス / グルタメイト脱水素酵素 / 低血糖 / アンモニア / インスリン / 肝臓 / 酵素 / 遺伝子 / 動物モデル / 高インスリン血症 / 高アンモニア血症 / グルタミン酸脱水素酵素 Less

幼若ミニブタを用いた乳幼児に適した経鼻ノロウイルスワクチンの開発Principal Investigator
- Principal Investigator
  
  徳原大介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Wakayama Medical University
酵母由来ザイモサンによる乳幼児に適した経鼻型ノロウイルスワクチンの開発Principal Investigator
- Principal Investigator
  
  徳原大介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Wakayama Medical University
Development of sublingual mucosal vaccine adjuvant for neonates and infantsPrincipal Investigator
- Principal Investigator
  
  TOKUHARA Daisuke
- Project Period (FY)
  2018
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Development of sublingual mucosal vaccine adjuvant for neonates and infantsPrincipal Investigator
- Principal Investigator
  
  TOKUHARA DAISUKE
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Development of Nasal Vaccine agaisnt RS virus based on neonatal innate immunity
- Principal Investigator
  
  Saito Mika
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Osaka City University
Analysis of vaccine-mediated immune induction in Mucopolysaccharidosis-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  Tokuhara Daisuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Pathophysiological study and the developments of therapy using mouse model of glutamate dehydrogenase disorder
- Principal Investigator
  
  OKANO YOSHIYUKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hyogo Medical University
乳幼児の呼吸器・消化管感染症に対する次世代型舌下粘膜ワクチンの開発Principal Investigator
- Principal Investigator
  
  徳原大介
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University

All 2023 2022 2019 2017 2016 2015 2014 Other

All Journal Article Presentation Patent Other

[Journal Article] A comprehensive understanding of the gut mucosal immune system in allergic inflammation2019
- Author(s)
  Tokuhara Daisuke、Kurashima Yosuke、Kamioka Mariko、Nakayama Toshinori、Ernst Peter、Kiyono Hiroshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 68 Issue: 1 Pages: 17-25
- DOI
  10.1016/j.alit.2018.09.004
- NAID
  130007557958
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19550, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-18H04046, KAKENHI-PROJECT-16H06243, KAKENHI-PROJECT-16K10039, KAKENHI-PROJECT-17KK0196
[Journal Article] Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells2017
- Author(s)
  Akitoshi Tsuruhara, Kazuyoshi Aso, Daisuke Tokuhara, Junichiro Ohori, Masaki Kawabata, Yuichi Kurono, Jerry R McGhee, Kohtaro Fujihashi
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 1 Pages: 5-10
- DOI
  10.1093/intimm/dxx001
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670514
[Journal Article] Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte.2016
- Author(s)
  Yanai S, Tokuhara D, Tachibana D, Saito M, Sakashita Y, Shintaku H, Koyama M.
- Journal Title
  
  J Reprod Immuno
  
  Volume: 117 Pages: 17-23
- DOI
  10.1016/j.jri.2016.06.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11147, KAKENHI-PROJECT-26670514
[Journal Article] Zymosan induces immune responses comparable with those of adults in monocytes, dendritic cells, and monocyte-derived dendritic cells from cord blood2015
- Author(s)
  Kyoko Nohmi, Daisuke Tokuhara, Daisuke Tachibana, Mika Saito, Yuko Sakashita, Akemi Nakano, Hiroyuki Terada, Hiroko Yamamoto, Masayasu Koyama, Haruo Shintaku
- Journal Title
  
  Journal of Pediatrics
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670514
[Journal Article] Zymosan Induces Immune Responses Comparable with Those of Adults in Monocytes, Dendritic Cells, and Monocyte-Derived Dendritic Cells from Cord Blood.2015
- Author(s)
  Nohmi K, Tokuhara D, Tachibana D, Saito M, Sakashita Y, Nakano A, Terada H, Katayama H, Koyama M, Shintaku H.
- Journal Title
  
  Journal of Pediatrics
  
  Volume: 167 Issue: 1 Pages: 155-162
- DOI
  10.1016/j.jpeds.2015.03.035
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461558
[Journal Article] Zymosan induces immune responses comparable with those of adults in monocytes, dendritic cells, and monocyte-derived dendritic cells from cord blood2015
- Author(s)
  Kyoko Nohmi, Daisuke Tokuhara, Daisuke Tachibana, Mika Saito, Yuko Sakashita, Akemi Nakano, Hiroyuki Terada, Hiroko Yamamoto, Masayasu Koyama, Haruo Shintaku
- Journal Title
  
  Journal of Pediatrics
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461558
[Journal Article] Role of per-rectal portal scintigraphy in long-term follow-up of congenital portosystemic shunt.2014
- Author(s)
  Cho Y, Tokuhara D, Shimono T, Yamamoto A, Higashiyama S, Kotani K, Kawabe J, Okano Y, Shiomi S, Shintaku H
- Journal Title
  
  Pediatr Res.
  
  Volume: 75 Pages: 658-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Patent] 幼若対象用の経鼻ワクチンアジュバント2023
- Inventor(s)
  徳原大介
- Industrial Property Rights Holder
  徳原大介
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K07942
[Presentation] 乳幼児に適した経鼻ノロウイルスワクチンの開発2022
- Author(s)
  土橋智弥、佐藤友香、徳原大介
- Organizer
  第19回日本小児消化管感染症研究会
- Data Source
  KAKENHI-PROJECT-22K07942
[Presentation] 乳幼児に特化した次世代型ノロウイルスワクチンの開発2019
- Author(s)
  徳原大介
- Organizer
  第１２２回日本小児科学会学術集会（金沢）
- Data Source
  KAKENHI-PROJECT-16K10039
[Presentation] 臍帯血由来単球におけるTLRを介した自然免疫応答の解析2019
- Author(s)
  匹田典克、徳原大介
- Organizer
  第１２２回日本小児科学会学術集会（金沢）
- Data Source
  KAKENHI-PROJECT-16K10039
[Presentation] 臍帯血由来単球におけるTLRを介した自然免疫応答の解析2019
- Author(s)
  匹田　典克、徳原　大介
- Organizer
  第１２２回日本小児科学会学術集会（金沢）
- Data Source
  KAKENHI-PROJECT-17KK0196
[Presentation] Intratissue commensal bacteria in Peyer’s Patches.2019
- Author(s)
  Tokuhara D
- Organizer
  3rd Annual Symposium for the Center for Mucosal Immunology, Allergy and Vaccine Development.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0196
[Presentation] 乳幼児に特化した次世代型ノロウイルスワクチンの開発2019
- Author(s)
  徳原　大介
- Organizer
  第１２２回日本小児科学会学術集会（金沢）
- Data Source
  KAKENHI-PROJECT-17KK0196
[Presentation] Diabetic pregnancy activates innate immune response through TLR5 or TLR1/2 on cord blood-derived monocytes.2016
- Author(s)
  Daisuke Tokuhara, Sakika Yanai, Daisuke Tachibana, Mika Saito, Yuki Cho, Masayasu Koyama, Haruo Shintaku.
- Organizer
  6th International Congress of UENPS.
- Place of Presentation
  バレンシア、スペイン
- Year and Date
  2016-11-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] TLR2/TLR6 heterodimer-mediated innate immune response in cord blood immune cells.2016
- Author(s)
  Yuki Cho, Daisuke Tokuhara, Kyoko Nohmi, Mika Saito, Daisuke Tachibana, Masayasu Koyama, Haruo Shintaku.
- Organizer
  6th International Congress of UENPS.
- Place of Presentation
  バレンシア、スペイン
- Year and Date
  2016-11-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] 妊娠中の糖代謝異常は新生児における過剰な自然免疫応答を惹起する．2016
- Author(s)
  柳井咲花，徳原大介，橘大輔，斎藤三佳，新宅治夫，古山将康．
- Organizer
  第１１９回日本小児科学会学術集会．
- Place of Presentation
  ロイトン札幌、札幌
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] 臍帯血由来免疫細胞の自然免疫機構を基盤とした, 乳幼児の消化管感染症に対するワクチンアジュバント開発．2015
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  第４２回日本小児栄養消化器肝臓学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] Zymosan induces innate immune responses in neonates comparable to adults.2015
- Author(s)
  Nohmi Kyoko, Daisuke Tokuhara, Saito Mika, Shintaku Haruo
- Organizer
  Asian Society for Pediatric Research 2015.
- Place of Presentation
  Osaka International Convention Center (Osaka, Japan)
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] 臍帯血由来免疫細胞の自然免疫応答を基盤とした、乳幼児の消化管感染症に対するワクチンアジュバント開発2015
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  第４２回日本小児栄養消化器肝臓学会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461558
[Presentation] Zymosan but not other TLR agonists, induces immune responses comparable to those of adults in monocytes, DCs, and monocyte-derived DCs of neonates.2015
- Author(s)
  Daisuke Tokuhara, Nohmi Kyoko, Saito Mika, Shintaku Haruo
- Organizer
  European Academy of Paediatrics Congress and Mastercourse 2015
- Place of Presentation
  Holmenkollen Park Hotel(Oslo, Norway)
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461558
[Presentation] Zymosan but not other TLR agonists, induces immune responses comparable to those of adults in monocytes, DCs, and monocyte-derived DCs of neonates.2015
- Author(s)
  Daisuke Tokuhara, Nohmi Kyoko, Saito Mika, Shintaku Haruo
- Organizer
  European Academy of Paediatrics Congress and Mastercourse 2015
- Place of Presentation
  Holmenkollen Park Hotel (Oslo, Norway)
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] ZYMOSAN BUT NOT LPS, PAM3CSK4, OR FLAGELLIN INDUCES IMMUNE RESPONSES IN MONOCYTES, DCS, AND MONOCYTE-DERIVED DCS OF NEONATES COMPARABLE TO THOSE OF ADULTS
- Author(s)
  Daisuke Tokuhara, Kyoko Nohmi, Haruo Shintaku
- Organizer
  The 5th Congress of the European Academy of Paediatric Societies
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2014-10-17 – 2014-10-21
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] TLR2リガンドは成人と同等の自然免疫応答を新生児に誘導する
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  第１１８回日本小児科学会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2015-04-17 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] ヒト臍帯血細胞を用いた新生児の自然免疫機構の解明：TLR2リガンドは成人と同等の自然免疫応答を新生児に誘導しうる
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  日本未熟児新生児学会
- Place of Presentation
  ひめぎんホール（愛媛県・松山市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26670514
[Presentation] ヒト臍帯血細胞を用いた新生児の自然免疫機構の解明：TLR2リガンドは成人と同等の自然免疫応答を新生児に誘導しうる
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  日本未熟児新生児学会
- Place of Presentation
  ひめぎんホール（愛媛県・松山市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25461558
[Presentation] ZYMOSAN BUT NOT LPS, PAM3CSK4, OR FLAGELLIN INDUCES IMMUNE RESPONSES IN MONOCYTES, DCS, AND MONOCYTE-DERIVED DCS OF NEONATES COMPARABLE TO THOSE OF ADULTS
- Author(s)
  Daisuke Tokuhara, Kyoko Nohmi, Haruo Shintaku
- Organizer
  The 5th Congress of the European Academy of Paediatric Societies
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2014-10-17 – 2014-10-21
- Data Source
  KAKENHI-PROJECT-25461558
[Presentation] TLR2リガンドは成人と同等の自然免疫応答を新生児に誘導する
- Author(s)
  能見恭子、徳原大介、齊藤三佳、新宅治夫
- Organizer
  第１１８回日本小児科学会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2015-04-17 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-25461558
[]

1. 趙有季 (80779398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. OKANO YOSHIYUKI (60231213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MORITA Takashi (70150349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAHEKI Takeyori (10056070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Saito Mika (40419700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. Ernst PETER B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIYONO hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIKITA norikatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. TACHIBANA daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 古山将康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tokuhara Daisuke 徳原 大介

徳原 大介 トクハラ ダイスケ

TOKUHARA Daisuke 徳原 大介

Research Projects

Research Products

Co-Researchers

幼若ミニブタを用いた乳幼児に適した経鼻ノロウイルスワクチンの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酵母由来ザイモサンによる乳幼児に適した経鼻型ノロウイルスワクチンの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of sublingual mucosal vaccine adjuvant for neonates and infantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of sublingual mucosal vaccine adjuvant for neonates and infantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Nasal Vaccine agaisnt RS virus based on neonatal innate immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of vaccine-mediated immune induction in Mucopolysaccharidosis-specific iPS cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiological study and the developments of therapy using mouse model of glutamate dehydrogenase disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

乳幼児の呼吸器・消化管感染症に対する次世代型舌下粘膜ワクチンの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A comprehensive understanding of the gut mucosal immune system in allergic inflammation2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zymosan induces immune responses comparable with those of adults in monocytes, dendritic cells, and monocyte-derived dendritic cells from cord blood2015

Author(s)

Journal Title

Data Source

[Journal Article] Zymosan Induces Immune Responses Comparable with Those of Adults in Monocytes, Dendritic Cells, and Monocyte-Derived Dendritic Cells from Cord Blood.2015

Author(s)

Journal Title

DOI

Tokuhara Daisuke 徳原大介

徳原大介トクハラダイスケ

TOKUHARA Daisuke 徳原大介