Fujikake Nobuhiro 藤掛伸宏

… Alternative Names

FUJIKAKE Nobuhiro 藤掛伸宏

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Researcher Number	60467595
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員
Affiliation (based on the past Project Information) *help	2016 – 2018: 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員 2011 – 2012: 独立行政法人国立精神・神経医療研究センター, 疾病研究第四部, 科研費研究員 2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第四部, 科研費研究員 2009: 国立精神・神経センター, 科研費研究員 … More 2009: National Center of Neurology and Psychiatry, 神経研究所疾病研究第四部, 科研費研究員 2009: National Center of Neurology and Psychiatry, 神経研究所疾病研究第四部, 外来研究員 2008: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第四部, 外来研究員 Less
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 神経変性疾患 / ショウジョウバエ / 神経科学 / 遺伝子 / 遺伝学 / TDP-43 / 筋萎縮性側索硬化症 / 脳神経疾患 / 神経変性 / オートファジー … More / ＴＤＰ－４３ / dynactin 1 / 神経分子病態学 / ALS / 神学経科 / スクリーニング / ポリグルタミン病 … More Except Principal Investigator ショウジョウバエ / ポリグルタミン病 / 神経変性疾患 / 脳神経疾患 / 神経科学 / 遺伝子 / 遺伝学 / 蛋白質分解 / 蛋白質 / トランスポーター / スクリーニング / ショウジョウバェ Less

Analysis of neurodegenerative diseases by focusing on the alternative autophagyPrincipal Investigator
- Principal Investigator
  
  FUJIKAKE Nobuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
In vivo analyses of networks in ALS-causing genes using fly modelsPrincipal Investigator
- Principal Investigator
  
  FUJIKAKE Nobuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
Establishment of novel Drosophila models of ALS expressing TDP-43, and analyses of its pathomechanismsPrincipal Investigator
- Principal Investigator
  
  FUJIKAKE Nobuhiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
神経変性疾患におけるタンパク質分解経路間のクロストークの個体レベルでの統合的理解
- Principal Investigator
  
  永井義隆
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
ポリグルタミン病における可逆性神経機能障害の分子メカニズムの解明
- Principal Investigator
  
  永井義隆
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
SLC7ファミリーが関わる神経変性疾患ポリグルタミン病の病態解明と治療法開発
- Principal Investigator
  
  永井義隆
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
A genetic screen for modifier of polyglutamine-induced neuronal dysfunction in vivoPrincipal Investigator
- Principal Investigator
  
  FUJIKAKE Nobuhiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

All 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Association Between Autophagy and Neurodegenerative Diseases2018
- Author(s)
  Nobuhiro Fujikake, Minkyoung Shin and Shigeomi Shimizu
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09668
[Journal Article] p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2015
- Author(s)
  Saitoh Y, Fujikake N, Okamoto Y, Popiel HA, Hatanaka Y, Ueyama M, Suzuki M, Gaumer S, Murata M, Wada K, Nagai Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 3 Pages: 1442-53
- DOI
  10.1074/jbc.m114.590281
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24591287, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-15K09331
[Journal Article] その他の FTLD―異常蛋白の視点から2015
- Author(s)
  上山盛夫、藤掛伸宏、永井義隆
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 33 Pages: 312-4
- Data Source
  KAKENHI-PROJECT-24591286
[Journal Article] VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.2014
- Author(s)
  Miura E, Hasegawa T, Konno M, Suzuki M, Sugeno N, Fujikake N, Geisler S, Tabuchi M, Oshima R, Kikuchi A, Baba T, Wada K, Nagai Y, Takeda A, Aoki M.
- Journal Title
  
  Neurobio Dis
  
  Volume: 71 Pages: 1-13
- DOI
  10.1016/j.nbd.2014.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591266, KAKENHI-PROJECT-24390219, KAKENHI-PROJECT-24591286, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-26461263, KAKENHI-PROJECT-26461303, KAKENHI-PROJECT-26670446
[Journal Article] Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS2014
- Author(s)
  Azuma Y., Tokuda T., Shimamura M., Kyotani A., Sasayama H., Yoshida T., Mizuta I., Mizuno T., Nakagawa M., Fujikake N., Ueyama M., Nagai Y., Yamaguchi M
- Journal Title
  
  Hum. Mol. Genet
  
  Volume: 23(13) Issue: 13 Pages: 3467-3480
- DOI
  10.1093/hmg/ddu055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-25860733, KAKENHI-PROJECT-26670446
[Journal Article] コンフォメーション病としての神経変性疾患2013
- Author(s)
  永井義隆、藤掛伸宏
- Journal Title
  
  ファルマシア
  
  Volume: 49 Pages: 849-853
- NAID
  110009995811
- Data Source
  KAKENHI-PROJECT-24591286
[Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
- Author(s)
  藤掛伸宏、長野清一、永井義隆
- Journal Title
  
  神経内科
  
  Volume: vol.76 Pages: 266-274
- URL
  http://www.kahyo.com/item/S201203-763
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] Knockdown of the Drosophila Fused in Sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.2012
- Author(s)
  Sasayama, H., Shimamura, M., Tokuda, T., Azuma, Y., Yoshida, T., Mizuno, T., Nakagawa, M., Fujikake, N., Nagai, Y. and Yamaguchi, M
- Journal Title
  
  PLoS ONE
  
  Volume: 7(6), Issue: 6 Pages: e39483-e39483
- DOI
  10.1371/journal.pone.0039483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241052, KAKENHI-PUBLICLY-23013015, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23570004, KAKENHI-PROJECT-23591252, KAKENHI-PROJECT-24406030, KAKENHI-PROJECT-24570211, KAKENHI-PROJECT-24591286, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-23110528
[Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012
- Author(s)
  藤掛伸宏, 長野清一, 永井義隆
- Journal Title
  
  神経肉科
  
  Volume: 76 Pages: 266-274
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
- Author(s)
  永井義隆、藤掛伸宏
- Journal Title
  
  Dementia Japan
  
  Volume: vol.25 Pages: 129-136
- URL
  http://www.sasappa.co.jp/online/abstract/jsdr/1/25/html/101250206.html
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] DP-43プロテイノパチーの動物モデル2011
- Author(s)
  永井義隆、藤掛伸宏
- Journal Title
  
  最新医学
  
  Volume: vol.65 Pages: 1603-1613
- URL
  http://www.saishin-igaku.co.jp/backnum/2010/y6507.html
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] ショウジョウバエモデルから解明されたTDP-43プロテイノパチーの分子病態2011
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Dementia Japan
  
  Volume: 25 Pages: 129-136
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] α-Synuclein transgenic Drosophila as a model of Parkinson's Disease and related synucleinopathies2011
- Author(s)
  Mizuno H, Fujikake N, Wada K, Nagai Y
- Journal Title
  
  Parkinsons Dis
  
  Volume: 2011 Pages: 212706-212706
- DOI
  10.4061/2011/212706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659172, KAKENHI-PROJECT-22790839
[Journal Article] TDP-43プロテイノパチーの動物モデル2010
- Author(s)
  永井義隆、藤掛伸宏
- Journal Title
  
  最新医学
  
  Volume: 65 Pages: 1603-1613
- Data Source
  KAKENHI-PUBLICLY-21025042
[Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Wada K
- Journal Title
  
  Current Pharmaceutical Biotechnology 11
  
  Pages: 188-97
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21025042
[Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Wada K
- Journal Title
  
  Current Pharmaceutical Biotechnology 11
  
  Pages: 188-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023019
[Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Wada K
- Journal Title
  
  Current Pharmaceutical Biotechnology 11
  
  Pages: 188-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Wada K.
- Journal Title
  
  Curr. Pharm. Biotech. 11
  
  Pages: 188-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] Genetic Testing for Huntington's Disease in Parkinsonism2010
- Author(s)
  Rahman MS, Nagai Y, Popiel HA, Fujikake N, et al
- Journal Title
  
  Mymensingh Medical Journal
  
  Volume: vol.19 Pages: 510-514
- URL
  http://www.banglajol.info/index.php/MMJ/article/view/6708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790839
[Journal Article] Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.2010
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Wada K
- Journal Title
  
  Current Pharmaceutical Biotechnology 11
  
  Pages: 188-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056021
[Journal Article] 神経疾患とシャペロンClin.2009
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Neurosci. 27
  
  Pages: 368-369
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] 神経疾患とシャペロン2009
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Clinical Neuroscience 27
  
  Pages: 368-9
- Data Source
  KAKENHI-PROJECT-20056021
[Journal Article] 神経疾患とシャペロン2009
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Clinical Neuroscience 27
  
  Pages: 368-9
- Data Source
  KAKENHI-PUBLICLY-21025042
[Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy.2009
- Author(s)
  Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T.
- Journal Title
  
  Hum. Mol. Genet. 18
  
  Pages: 621-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregation inhibitors to the expanded polyglutamine stretch.2009
- Author(s)
  Okamoto Y, Nagai Y, Fujikake N, Akiko Popiel H, Yoshioka T, Toda T, Inui T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 378
  
  Pages: 634-639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effects on polyglutamine disease mice.2009
- Author(s)
  Popiel HA, Nagai Y, Fujikake N, Toda T.
- Journal Title
  
  Neurosci. Lett. 449
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] 神経疾患とシャペロン2009
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Clinical Neuroscience 27
  
  Pages: 368-9
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] 神経疾患とシャペロン2009
- Author(s)
  永井義隆, 藤掛伸宏
- Journal Title
  
  Clinical Neuroscience 27
  
  Pages: 368-9
- Data Source
  KAKENHI-PROJECT-20023019
[Journal Article] Heat shock transcription factor 1(HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones2008
- Author(s)
  Fujikake, N.
- Journal Title
  
  J. Biol. Chem. 283(38)
  
  Pages: 26188-26197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023019
[Journal Article] Heat shock transcription factor 1(HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones2008
- Author(s)
  Fujikake, N.
- Journal Title
  
  J. Biol. Chem. 283(38)
  
  Pages: 26188-26197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20056021
[Journal Article] Heat shock transcription factor 1(HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones2008
- Author(s)
  Fujikake, N.
- Journal Title
  
  J. Biol.Chem. 283(38)
  
  Pages: 26188-26197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] ER stress is the initial response to polyglutamine toxicity in PC12 cells.2008
- Author(s)
  Nakayama H, Hamada M, Fujikake N, Nagai Y, Zhao J, Hatano O, Shimoke K, Isosaki M, Yoshizumi M, Ikeuchi T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 377
  
  Pages: 550-555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Journal Article] Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.2008
- Author(s)
  Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 26188-26197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] Effects of chemical activators of conventional and alternative autophagy on tauopathy　models2018
- Author(s)
  藤掛伸宏、清水貴美子、清水重臣
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K09668
[Presentation] 脳におけるAtg5/Atg7非依存的オートファジーの役割2016
- Author(s)
  藤掛伸宏、山口啓史、荒川聡子、清水重臣
- Organizer
  第39回分子生物学会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K09668
[Presentation] ショウジョウバエから始める神経変性疾患研究～TDP-43輸送の障害はオリゴマー化を促進し、神経変性を惹き起こす～2014
- Author(s)
  藤掛伸宏、畑中悠佑、長野清一、斉藤勇二、荒木敏之、和田圭司、永井義隆
- Organizer
  教育研修棟竣工記念シンポジウム
- Place of Presentation
  国立精神・神経医療研究センター教育研修棟、東京
- Year and Date
  2014-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] DCTN1依存的輸送の障害はTDP-43のオリゴマー形成を促進する2014
- Author(s)
  藤掛伸宏、木村展之、長野清一、斉藤勇二、横関明男、小野寺理、和田圭司、永井義隆
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2014-05-14
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Aggregation of TDP-43 is triggered by insufficiency of microtubule-dependent transport in the cytoplasm, leading to neurodegeneration in Drosophila2013
- Author(s)
  Fujikake N., Kimura N., Saitoh Y., Yokoseki A., Onodera O., Wada K., Nagai Y.
- Organizer
  11 th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD 2013)
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] DCTN1依存的輸送の障害によりTDP-43発現ショウジョウバエの神経変性は増悪する2013
- Author(s)
  藤掛伸宏、木村展之、長野清一、斉藤勇二、横関明男、小野寺理、和田圭司、永井義隆
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム、東京都
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Impairment of microtubule-dependent transport of TDP-43 triggers its aggregation, leading to neurodegeneration in Drosophila models of TDP-43 proteinopathies2013
- Author(s)
  Fujikake N, Kimura N, Saitoh Y, Suzuki M, Yokoseki A, Onodera O, Wada K, Nagai Y
- Organizer
  SfN2013
- Place of Presentation
  San Diego Convention Center, San Diego, USA
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Oligomerization of TDP-43 is triggered by impairment of microtubule-dependent transport, leading to neurodegeneration in Drosophila2013
- Author(s)
  Fujikake N, Kimura N, Saitoh Y, Suzuki M, Yokoseki A, Onodera O, Wada K, Nagai Y
- Organizer
  BRAI 2013
- Place of Presentation
  Sheraton San Diego Hotel & Marina, San Diego, USA
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] 微小管依存的輸送系の障害はTDP-43のオリゴマー形成を促進し、FTLDにおける神経変性を惹き起こす2013
- Author(s)
  藤掛伸宏
- Organizer
  認知症研究を知る若手研究者の集まり2013
- Place of Presentation
  和光純薬湯河原研修所、静岡県
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Aggravation of neurodegeneration by high-nutrient diet in Drosophila models of neurodegenerative diseases2012
- Author(s)
  Suzuki M., Fujikake N., Wada K., Nagai Y.
- Organizer
  Keystone Symposia on Aging and Diseases of Aging
- Place of Presentation
  Sheraton Miyako Hotel Tokyo, Tokyo
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] 微小管依存的輸送の障害はTDP-43の細胞質蓄積、オリゴマー形成を促進し、ALSにおける神経変性を惹き起こす2012
- Author(s)
  藤掛伸宏, 木村展之, 斉藤勇二, 横関明男, 小野寺理, 和田圭司, 永井義隆
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場、愛知
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] SCA6トランスジェニックショウジョウバエによるCav2.1のCTF毒性の検証2012
- Author(s)
  石黒太郎、石川欽也、藤掛伸宏、永井義隆、水澤英洋
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム、東京
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] TDP-43とFUSはショウジョウバエモデルにおいて相乗的に神経変性を惹き起こす2012
- Author(s)
  藤掛伸宏, 高橋光里, 斉藤勇二, 横関明男, 小野寺理, 和田圭司, 永井義隆
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム、東京
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Exosome-mediated cell-to-cell transmission of heat shock proteins contributes to the maintenance of protein homeostasis2012
- Author(s)
  Takeuchi T., Fujikake N., Wada K., Nagai Y.
- Organizer
  EMBO Symposium on Quality Control
- Place of Presentation
  Heidelberg, Germany
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] パーキンソン病モデルショウジョウバエにおけるα-synuclein毒性はglucocerebrosidaseの機能喪失により増悪する2012
- Author(s)
  鈴木マリ、藤掛伸宏、和田圭司、永井義隆
- Organizer
  第35回日本神経科学会
- Place of Presentation
  名古屋国際会議場、愛知
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] ポリグルタミン病モデルショウジョウバエの病態においてp62は保護的に機能している2012
- Author(s)
  斉藤勇二、藤掛伸宏、岡本佑馬、和田圭司、永井義隆
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム、東京
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] Disruption of microtubule-dependent transport of TDP-43 triggers aggregation of TDP-43, leading to neurodegeneration in Drosophila models of human disease2012
- Author(s)
  Fujikake N., Saitoh Y., Yokoseki A., Onodera O., Wada K., Nagai Y.
- Organizer
  第10回日本ショウジョウバエ研究会
- Place of Presentation
  東京慈恵会医科大学、東京
- Data Source
  KAKENHI-PROJECT-24591286
[Presentation] TDP-43を発現するALSモデルショウジョウバエにおけるオートファジー系蛋白質分解の関与2011
- Author(s)
  藤掛伸宏、斉藤勇二、横関明男、小野寺理、和田圭司、永井義隆
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] 高栄養負荷は神経変性疾患モデルショウジョウバエにおける神経変性を増悪する2011
- Author(s)
  鈴木マリ、藤掛伸宏、和田圭司、永井義隆
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] Expression of TDP-43 causes neurological phenotypes with an enhancement by FALS mutations in novel Drosophila models of ALS2011
- Author(s)
  Fujikake N., et al.
- Organizer
  10th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  CCIB Convention Center (Barcelona, Spain)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] Expression of TDP-43 causes neurological phenotypes with an enhancement by FALS mutations in novel Drosophila models of ALS2011
- Author(s)
  Fujikake N, Saitoh Y, Yokoseki A, Onodera O, Wada K, Nagai Y
- Organizer
  10th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  CCIB Convention Center(Barcelona, Spain)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] Expression of TDP-43 causes neurological phenotypes with an enhancement by FALS mutations in novel Drosophila models of ALS.2011
- Author(s)
  Fujikake N., et al.
- Organizer
  10th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  CCIB Barcelona (Spain)
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] TDP-43を発現する新規ALSモデルショウジョウバエの樹立とその病態解析2010
- Author(s)
  藤掛伸宏, 他
- Organizer
  第33回日本神経科学会・第53回日本神経化学会合同大会
- Place of Presentation
  神戸コンベンションセンター(兵庫)
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Abnormal accumulation of TDP-43 proteins causes neurodegeneration in novel Drosophila models of ALS.2010
- Author(s)
  Fujikake N., et al.
- Organizer
  3rd International Symposium on Protein Community
- Place of Presentation
  Hotel Nikko (Nara, Japan)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] Abnormal accumulation of TDP-43 proteins causes neurodegeneration in novel Drosophila models of ALS.2010
- Author(s)
  Fujikake N., et al.
- Organizer
  3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良(奈良)
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Abnormal accumulation of TDP-43 proteins causes neurodegeneration in novel Drosophila models of ALS2010
- Author(s)
  Fujikake N, Saitoh Y, Yokoseki A, Onodera O, Wada K, Nagai Y
- Organizer
  3rd International Symposium on Protein Community
- Place of Presentation
  Hotel Nikko(Nara, Japan)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] TDP-43を発現する新規ALSモデルショウジョウバエを用いた病態解析2010
- Author(s)
  永井義隆、藤掛伸宏、斉藤勇二、横関明男、小野寺理、和田圭司
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] TDP-43を発現する新規ALSモデルショウジョウバエの樹立とその病態解析2010
- Author(s)
  藤掛伸宏, 他
- Organizer
  第33回日本神経科学会・第53回日本神経化学会合同大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] TDP-43を発現する新規ALSモデルショウジョウバエの樹立とその病態解析2010
- Author(s)
  永井義隆、藤掛伸宏、斉藤勇二、横関明男、小野寺理
- Organizer
  第33回日本神経科学会・第53回日本神経化学会合同大会
- Place of Presentation
  神戸コンベンションセンター(兵庫県)
- Data Source
  KAKENHI-PROJECT-22790839
[Presentation] ポリグルタミン病モデルマウスに対する凝集阻害ペプチドQBP1を用いた遺伝子治療2009
- Author(s)
  ポピエル明子, 藤掛伸宏, 戸田達史, 村松慎一, 和田圭司, 永井義隆
- Organizer
  第82回日本生化学会
- Place of Presentation
  ポートアイランド、神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] Surface plasmon resonance as a useful technique for screening for specificpolyglutamine aggregation inhibitors.2009
- Author(s)
  Nagai Y, Okamoto Y, Fujikake N, Popiel HA, Inui T, Wada K
- Organizer
  5th Gordon Research Conferenceon CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Opposing effects of HSF1 expression on tau- and polyglutamine-inducedneurodegeneration in vivo.2009
- Author(s)
  Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.2009
- Author(s)
  Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K, Nagai Y
- Organizer
  5th Gordon Research Conferenceonl CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] 熱ショック転写因子(HSF1)活性剤は分子シャペロン群の発現を誘導し、ポリグルタミン病の神経変性を抑制する2009
- Author(s)
  永井義隆, 藤掛伸宏, ポピエル明子, 岡本佑馬, 山口政光, 戸田達史, 和田圭司
- Organizer
  第52回日本神経化学会
- Place of Presentation
  伊香保温泉ホテル天坊、群馬
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 17-AAG, an HSFI-activator, suppresses polyglutamine-induced neurodegeneration via induction of molecular chaperones.2009
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] Surface plasmon resonance as a useful technique for screening for specificpolyglutamine aggregation inhibitors.2009
- Author(s)
  Nagai Y, Okamoto Y, Fujikake N, Popiel HA, Inui T, Wada K
- Organizer
  5th Gordon Research Conference on CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 17-AAG, an HSF1-activator, suppresses polyglutamine-induced neurodegeneration via induction of molecular chaperones.2009
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] ポリグルタミン病モデルマウスに対する凝集阻害ペプチドQBP1を用いた遺伝子治療2009
- Author(s)
  ポピエル明子, 藤掛伸宏, 戸田達史, 村松慎一, 和田圭司, 永井義隆
- Organizer
  第82回日本生化学会
- Place of Presentation
  ポートアイランド、神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Opposing effects of HSFl expression on tau- and polyglutamine-induced neurodegeneration in vivo.2009
- Author(s)
  Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] 熱ショック転写因子(HSF1)活性剤は分子シャペロン群の発現を誘導し、ポリグルタミン病の神経変性を抑制する2009
- Author(s)
  永井義隆, 藤掛伸宏, ポピエル明子, 岡本佑馬, 山口政光, 戸田達史, 和田圭司
- Organizer
  第52回日本神経化学会
- Place of Presentation
  伊香保温泉ホテル天坊、群馬
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] Surface plasmon resonance as a useful technique for screening fbr specific polyglutamine aggregation inhibitors.2009
- Author(s)
  Nagai Y, Okamoto Y, Fujikake N, Popiel HA, Inui T, Wada K
- Organizer
  5th Gordon Research Conference on CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] ポリグルタミン病モデルマウスに対する凝集阻害ペプチドQBP1を用いた遺伝子治療2009
- Author(s)
  ポピエル明子, 藤掛伸宏, 戸田達史, 村松慎一, 和田圭司, 永井義隆
- Organizer
  第82回日本生化学会
- Place of Presentation
  ポートアイランド、神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiplemolecular chaperones.2009
- Author(s)
  Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K, Nagai Y
- Organizer
  5th Gordon Research Conference on CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 凝集阻害ペプチドQBP1を用いたポリグルタミン病に対する分子標的治療法の開発2009
- Author(s)
  永井義隆, ポピエル明子, 藤掛伸宏, 村松慎一, 戸田達史, 和田圭司
- Organizer
  第54回日本人類遺伝学会
- Place of Presentation
  グランドプリンスホテル高輪、東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 凝集阻害ペプチドQBP1を用いたポリグルタミン病に対する分子標的治療法の開発2009
- Author(s)
  永井義隆, ポピエル明子, 藤掛伸宏, 村松慎一, 戸田達史, 和田圭司
- Organizer
  第54回日本人類遺伝学会
- Place of Presentation
  グランドプリンスホテル高輪、東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 17-AAG, an HSF1-activator, suppresses polyglutamine-inducedneurodegeneration via induction of molecular chaperones.2009
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 17-AAG, an HSF1-activator, suppresses polyglutamine-induced neurodegeneration via induction of molecular chaperones.2009
- Author(s)
  Nagai Y, Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 凝集阻害ペプチドQBP1を用いたポリグルタミン病に対する分子標的治療法の開発2009
- Author(s)
  永井義隆, ポピエル明子, 藤掛伸宏, 村松慎一, 戸田達史, 和田圭司
- Organizer
  第54回日本人類遺伝学
- Place of Presentation
  グランドプリンスホテル高輪、東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20056021
[Presentation] Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.2009
- Author(s)
  Fujikake N, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K, Nagai Y
- Organizer
  5th Gordon Research Conferenceon CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] Surface plasmon resonance as a useful technique for screening for specific polyglutamine aggregation inhibitors.2009
- Author(s)
  Nagai Y, Okamoto Y, Fujikake N, Popiel HA, Inui T, Wada K
- Organizer
  5th Gordon Research Conferenceon CAG niplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] Opposing effects of HSF1 expression on tau- and polyglutamine-induced neurodegeneration in vivo.2009
- Author(s)
  Fujikake N.
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiplemolecular chaperones.2009
- Author(s)
  Fujikake N, Popiel HA, OkamotoY, Yamaguchi M, Toda T, Wada K, Nagai Y
- Organizer
  5th Gordon Research Conferenceon CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] 熱ショック転写因子(HSF1)活性剤は分子シャペロン群の発現を誘導し、ポリグルタミン病の神経変性を抑制する2009
- Author(s)
  永井義隆, 藤掛伸宏, ポピエル明子, 岡本佑馬, 山口政光, 戸田達史, 和田圭司
- Organizer
  第52回日本神経化学会
- Place of Presentation
  伊香保温泉ホテル天坊、群馬
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] Opposing effects of HSF1 expression on tau- and polyglutamine-induced neurodegeneration in vivo.2009
- Author(s)
  Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T, Wada K
- Organizer
  4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Gateaux Kingdom Sapporo Hotel & Spa Resort, Sapporo, Japan
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 凝集阻害ペプチドQBP1を用いたポリグルタミン病に対する分子標的治療法の開発2009
- Author(s)
  永井義隆, ポピエル明子, 藤掛伸宏, 村松慎一, 戸田達史, 和田圭司
- Organizer
  第54回日本人類遺伝学会
- Place of Presentation
  グランドプリンスホテル高輪、東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PUBLICLY-21025042
[Presentation] ポリグルタミン病モデルマウスに対する凝集阻害ペプチドQBP1を用いた遺伝子治療2009
- Author(s)
  ポピエル明子, 藤掛伸宏, 戸田達史, 村松慎一, 和田圭司, 永井義隆
- Organizer
  第82回日本生化学会
- Place of Presentation
  ポートアイランド、神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] Pharmacological activation of heat shock transcription factor 1 suppresses polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones.2009
- Author(s)
  Fujikake N.
- Organizer
  5th Gordon Research Conference on CAG Triplet Repeat Disorders
- Place of Presentation
  Waterville Valley Resort, USA
- Year and Date
  2009-05-31
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 熱ショック転写因子(HSF1)活性剤は分子シャペロン群の発現を誘導し、ポリグルタミン病の神経変性を抑制する2009
- Author(s)
  永井義隆, 藤掛伸宏, ポピエル明子, 岡本佑馬, 山口政光, 戸田達史, 和田圭司
- Organizer
  第52回日本神経化学会
- Place of Presentation
  伊香保温泉ホテル天坊、群馬
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 17-AAG投与による熱ショック転写因子の活性化はポリグルタミンが引き起こす神経変性を抑制する2008
- Author(s)
  藤掛伸宏
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20023019
[Presentation] 17-AAG投与による熱ショック転写因子の活性化はポリグルタミンが引き起こす神経変性を抑制する2008
- Author(s)
  藤掛伸宏
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 17-AAG投与による熱ショック転写因子の活性化はポリグルタミンが引き起こす神経変性を抑制する2008
- Author(s)
  藤掛伸宏
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京国際フォーラム, 東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20790612
[Presentation] 17-AAG投与による熱ショック転写因子の活性化はポリグルタミンが引き起こす神経変性を抑制する2008
- Author(s)
  藤掛伸宏
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20056021

1. 永井義隆 (60335354)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
2. KIKUCHI Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. YOSHIDA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 武田篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山口政光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujikake Nobuhiro 藤掛 伸宏

FUJIKAKE Nobuhiro 藤掛 伸宏

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Analysis of neurodegenerative diseases by focusing on the alternative autophagyPrincipal Investigator

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In vivo analyses of networks in ALS-causing genes using fly modelsPrincipal Investigator

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Establishment of novel Drosophila models of ALS expressing TDP-43, and analyses of its pathomechanismsPrincipal Investigator

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神経変性疾患におけるタンパク質分解経路間のクロストークの個体レベルでの統合的理解

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ポリグルタミン病における可逆性神経機能障害の分子メカニズムの解明

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SLC7ファミリーが関わる神経変性疾患ポリグルタミン病の病態解明と治療法開発

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A genetic screen for modifier of polyglutamine-induced neuronal dysfunction in vivoPrincipal Investigator

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[Journal Article] Association Between Autophagy and Neurodegenerative Diseases2018

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[Journal Article] p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies.2015

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[Journal Article] その他の FTLD―異常蛋白の視点から2015

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[Journal Article] VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.2014

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[Journal Article] Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS2014

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[Journal Article] コンフォメーション病としての神経変性疾患2013

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[Journal Article] ショウジョウバエなど小動物を用いた筋萎縮性側索硬化症モデル2012

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Fujikake Nobuhiro 藤掛伸宏

FUJIKAKE Nobuhiro 藤掛伸宏