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Miyanari Yusuke  宮成 悠介

ORCIDConnect your ORCID iD *help
Researcher Number 60469608
Other IDs
Affiliation (Current) 2025: 金沢大学, ナノ生命科学研究所, 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 金沢大学, ナノ生命科学研究所, 准教授
2018 – 2020: 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 特任准教授
2017: 大学共同利用機関法人自然科学研究機構(新分野創成センター), 生命創成探究センター, 特任准教授
2014 – 2016: 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特任准教授
Review Section/Research Field
Principal Investigator
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Molecular biology / Morphology/Structure / Developmental biology
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Basic Section 63020:Radiation influence-related
Keywords
Principal Investigator
クロマチン / エピジェネティクス / 遺伝学 / 転写 / ゲノム / 核内構造 / クロマチン構造 / PML / 転写制御 / PML body / 核内構造体 / ゲノム構造 / クロマチン高次構造 … More
Except Principal Investigator
… More ナノボディ / PROTACS / 膵臓がん / セラノスティクス / 転写 / DSB修復 / 染色体転座 / クロマチン / HR / NHEJ / 放射線 / DNA修復 / 放射性薬剤 / イメージング / 分子イメージング / 膵臓癌 / PET Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (9 People)
  •  In cell analysis of chromatin regulating complexesPrincipal Investigator

    • Principal Investigator
      宮成 悠介
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kanazawa University
  •  Development of theranostics agents combining nanobodies and PROTACs for pancreatic cancer

    • Principal Investigator
      淵上 剛志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Kanazawa University
  •  Dissecting a transcriptional domainPrincipal Investigator

    • Principal Investigator
      宮成 悠介
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Kanazawa University
  •  全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究

    • Principal Investigator
      柴田 淳史
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 63020:Radiation influence-related
    • Research Institution
      Keio University
      Gunma University
  •  Development of nanobody molecular probes for early diagnosis of pancreatic cancers

    • Principal Investigator
      FUCHIGAMI Takeshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Nagasaki University
  •  Regulation of chromatin accessibilityPrincipal Investigator

    • Principal Investigator
      宮成 悠介
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
  •  How to get transparency for generation of transparent animals.Principal Investigator

    • Principal Investigator
      Miyanari Yusuke
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Morphology/Structure
    • Research Institution
      Okazaki Research Facilities, National Institutes of Natural Sciences
  •  Uncovering roles of PML bodies in transcriptionPrincipal Investigator

    • Principal Investigator
      Miyanari Yusuke
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Molecular biology
    • Research Institution
      Center for Novel Science Initatives, National Institutes of Natural Sciences
      Okazaki Research Facilities, National Institutes of Natural Sciences
  •  クロマチンイメージングによって解き明かす転写制御機構Principal Investigator

    • Principal Investigator
      宮成 悠介
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Developmental biology
    • Research Institution
      Okazaki Research Facilities, National Institutes of Natural Sciences

All 2023 2022 2021 2020 2019 2018 2017 2016 Other

All Journal Article Presentation Patent

  • [Journal Article] Imaging Chromatin Accessibility by Assay of Transposase-Accessible Chromatin with Visualization2022

    • Author(s)
      Miyanari Yusuke
    • Journal Title

      Methods in Molecular Biology

      Volume: 2577 Pages: 93-101

    • DOI

      10.1007/978-1-0716-2724-2_7

    • ISBN
      9781071627235, 9781071627242
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H04765
  • [Journal Article] Borealin-Derived Peptides as Survivin-Targeting Cancer Imaging and Therapeutic Agents2022

    • Author(s)
      Nozaki Iori、Ishikawa Natsumi、Miyanari Yusuke、Ogawa Kazuma、Tagawa Ayako、Yoshida Sakura、Munekane Masayuki、Mishiro Kenji、Toriba Akira、Nakayama Morio、Fuchigami Takeshi
    • Journal Title

      Bioconjugate Chemistry

      Volume: 33 Issue: 11 Pages: 2149-2160

    • DOI

      10.1021/acs.bioconjchem.2c00398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K19452, KAKENHI-PROJECT-21H04765, KAKENHI-PUBLICLY-22H04688, KAKENHI-PROJECT-23K24276
  • [Journal Article] Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion2020

    • Author(s)
      Kurihara Misuzu、Kato Kagayaki、Sanbo Chiaki、Shigenobu Shuji、Ohkawa Yasuyuki、Fuchigami Takeshi、Miyanari Yusuke
    • Journal Title

      Molecular Cell

      Volume: 78 Issue: 3 Pages: 493-505

    • DOI

      10.1016/j.molcel.2020.04.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14632, KAKENHI-PROJECT-20K21398, KAKENHI-PLANNED-18H05527, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-20H04846, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-18K07756, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H03424
  • [Journal Article] Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin.2020

    • Author(s)
      Fuchigami T, Ishikawa N, Nozaki I, Miyanari Y, Yoshida S, Yamauchi M, Soejima A, Haratake M, Nakayama M
    • Journal Title

      Cancer Sci

      Volume: 111(4) Issue: 4 Pages: 1357-1366

    • DOI

      10.1111/cas.14330

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07756, KAKENHI-PROJECT-18K06617
  • [Journal Article] Histone H1 quantity determines the efficiency of chromatin condensation in both apoptotic and live cells2019

    • Author(s)
      Marie Kijima, Hiroyuki Yamagishi, Yasushi Hara, Mai Kasai, Yasunari Takami, Hiroshi Takemura, Yusuke Miyanari, Yoichi Shinkai, Ryushin Mizuta
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

      Volume: 512 Issue: 2 Pages: 202-207

    • DOI

      10.1016/j.bbrc.2019.03.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08891, KAKENHI-PROJECT-15H05586
  • [Journal Article] 核内ボディによる転写制御機構2016

    • Author(s)
      栗原美寿々、宮成悠介
    • Journal Title

      Journal of Japanese Biochemical Society

      Volume: 88 Pages: 521-524

    • NAID

      40020948579

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05586
  • [Patent] 膵臓がん抗原に対するVHH抗体及び膵臓がん細胞検出方法2023

    • Inventor(s)
      淵上剛志, 宮成悠 介, 田川綾子, 小 川数馬,他
    • Industrial Property Rights Holder
      淵上剛志, 宮成悠 介, 田川綾子, 小 川数馬,他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-032216
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-23K24276
  • [Patent] 膵臓がん抗原に対するVHH抗体及び膵臓がん細胞検出方法2022

    • Inventor(s)
      宮成悠介、淵上剛志
    • Industrial Property Rights Holder
      宮成悠介、淵上剛志
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Data Source
      KAKENHI-PUBLICLY-22H04688
  • [Presentation] Preparation and evaluation of an ADAM8-targeted 111In-labeled antibody for the detection of early pancreatic cancer2023

    • Author(s)
      T. Fuchigami, T. Kosugi, Y. Miyanari, A. Tagawa, T. Adachi, K. Nishi, S. Yoshida, K. Mishiro, M. Munekane, A. Toriba, K. Ogawa
    • Organizer
      The 25th International Symposium of Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24276
  • [Presentation] 膵臓がんの初期段階での検出を目的とした ADAM8 標的とする核医学イメージングプローブの開発2022

    • Author(s)
      小杉司, 淵上剛志, 宮成悠介, 田川綾子, 山口凉太, 足立智彦, 西弘大, 吉田さくら, 鳥羽陽, 小川数馬
    • Organizer
      第19回次世代を担う若手のためのフィジカル・ファーマフォーラム(PPF2022)
    • Data Source
      KAKENHI-PROJECT-23K24276
  • [Presentation] Survivin 標的Borealin 由来ペプチドを利用したがん診断治療法の開発2022

    • Author(s)
      野﨑伊織, 石川夏海, 宮成悠介, 田川綾子, 吉田さくら, 鳥羽陽, 中山守雄, 小川数馬, 淵上剛志
    • Organizer
      第34回バイオメディカル分析科学シンポジウム(BMAS2022)
    • Data Source
      KAKENHI-PROJECT-23K24276
  • [Presentation] 初期膵癌の検出を目的とするADAM8 標的111In 標識イメージング薬剤の開発2022

    • Author(s)
      小杉司, 淵上剛志, 宮成悠介, 田川綾子, 山口凉太, 足立智彦, 西弘大, 吉田さくら, 鳥羽陽, 小川数馬
    • Organizer
      日本薬学会北陸支部 第134回例会
    • Data Source
      KAKENHI-PROJECT-23K24276
  • [Presentation] ADAM8を標的とした放射性ガリウム標識ペプチドの合成と酵素活性応答型分子プローブとしての有用性評価2021

    • Author(s)
      山口 涼太,小杉 司,宮成 悠介,田川 綾子,吉田 さくら,中山 守雄,鳥羽 陽,淵上剛志
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K07756
  • [Presentation] 膵臓がんの早期画像診断を目的とした 111In標識抗ADAM8抗体の開発2021

    • Author(s)
      小杉 司,山口 涼太,棚原 悠介,宮成 悠介,田川 綾子,足立 智彦,吉田 さくら,鳥羽 陽,淵上 剛志
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K07756
  • [Presentation] がん選択的な治療や診断への応用を目指した survivinを標的とする架橋ペプチドの開発2021

    • Author(s)
      副島 歩実,野﨑 伊織,石川 夏海,宮成 悠介,田川 綾子,吉田 さくら,中山 守雄,鳥羽 陽,淵上 剛志
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18K07756
  • [Presentation] Genome-wide screening for regulators of chromatin accessibility2019

    • Author(s)
      Yusuke Miyanari
    • Organizer
      第8回植物RNA研究ネットシンポジウム、滋賀
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Development of Borealin derived peptides for survivin targeting cancer treatment2019

    • Author(s)
      Iori Nozaki, Takeshi Fuchigami, Natsumi Ishikawa, Yusuke Miyanari, Motohiro Yamauchi, Riru Yamashita, Yumi Ikeda, Sakura Yoshida, and Morio Nakayama
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-18K07756
  • [Presentation] Genome-wide screening for effectors to chromatin accessiblity2019

    • Author(s)
      Yusuke Miyanari
    • Organizer
      10th CHROMOSOME ORCHESTRATION SYSTEM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Genome-wide screening for regulators of chromatin accessibility2019

    • Author(s)
      Yusuke Miyanari
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Survivinを標的としたBorealin由来ペプチドの合成とがん診断剤および治療薬としての基礎評価2019

    • Author(s)
      野﨑 伊織, 淵上 剛志, 石川 夏海, 宮成 悠介,山内 基弘,池田 由美, 山下 莉瑠,吉田 さくら, 中山 守雄
    • Organizer
      第36回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-18K07756
  • [Presentation] Genome-wide screening for effectors to chromatin accessiblity2018

    • Author(s)
      Yusuke Miyanari
    • Organizer
      METP REUNION
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Roles of PML body in transcription2018

    • Author(s)
      宮成悠介, 栗原美寿々
    • Organizer
      第41会分子生物学会年会 パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05586
  • [Presentation] Genome-wide screening for regulators of chromatin accessibility2018

    • Author(s)
      Yusuke Miyanari
    • Organizer
      2018 NIG international Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Genome-wide screening of key factors regulating chromatin accessiblity2018

    • Author(s)
      Yusuke Miyanari
    • Organizer
      9th CHROMOSOME ORCHESTRATION SYSTEM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04722
  • [Presentation] Uncovering the role of PML bodies in gene expression by APEX-ChIP2017

    • Author(s)
      栗原美寿々、三宝千秋、淵上剛、大川恭行、宮成悠介
    • Organizer
      染色体ワークショップ
    • Place of Presentation
      かずさDNA研究所(千葉県、木更津市)
    • Year and Date
      2017-01-11
    • Data Source
      KAKENHI-PROJECT-15H05586
  • [Presentation] Roles of PML body in transcription2017

    • Author(s)
      宮成悠介, 栗原美寿々
    • Organizer
      染色体ワークショップ
    • Data Source
      KAKENHI-PROJECT-15H05586
  • [Presentation] Uncovering the role of PML bodies in gene expression by APEX-ChIP2016

    • Author(s)
      栗原美寿々、三宝千秋、淵上剛、大川恭行、宮成悠介
    • Organizer
      第39回分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H05586
  • [Presentation] Reprogramming and nuclear dynamics

    • Author(s)
      Yusuke Miyanari
    • Organizer
      4D nucleome
    • Place of Presentation
      安芸グランドホテル、広島, 安芸
    • Year and Date
      2014-12-19 – 2014-12-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26891031
  • 1.  FUCHIGAMI Takeshi (30432206)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 2.  吉田 さくら (40736419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 3.  中山 守雄 (60164373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  柴田 淳史 (30707633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  山内 基弘 (60437910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  安原 崇哲 (90757056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  小川 数馬 (30347471)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  MIZUTA Ryushin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  栗原 美寿々
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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