Sugimoto Chie 杉本智恵

Researcher Number	60469955
Other IDs	https://orcid.org/0000-0002-0488-2931
Affiliation (Current)	2025: 獨協医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 獨協医科大学, 医学部, 准教授 2017 – 2019: 獨協医科大学, 医学部, 講師 2016: 北海道大学, 医学研究科, 助教 2014 – 2015: 北海道大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Laboratory animal science / Basic Section 42040:Laboratory animal science-related Except Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 54030:Infectious disease medicine-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator 自然免疫型T細胞 / 感染免疫 / 呼吸器 / ウイルス感染 / 疾患モデル / 発生・分化 / 再生医学 / 細菌感染 / モデル動物 / アカゲザル / 自然免疫系T細胞 / 動物モデル / MAIT細胞 … More Except Principal Investigator … More MAIT細胞 / iPS細胞 / キメラ抗原受容体(CAR) / 抗がん / 自然免疫型T細胞 / 分化誘導 / キメラ抗原受容体 / 中皮腫 / マウス / 細胞傷害活性 / 抗がん活性 / 養子移入 / ピーナッツ / アナフィラキシー / 食物アレルギー / 既製細胞医薬 / ヒト / 血液幹細胞 / APOBEC3G / 自然免疫 / CD8陽性細胞 / IL-15 / SIV / 感染防御免疫 / CAR / プロモーター / がん抗原 / マウスiPS細胞 / 生体防御能 / 加齢 / 免疫能低下 / ２型自然リンパ球 / アルテルナリア / BALF / PAS染色 / Thサイトカイン / 新規マウスモデル / アレルギー / 2型自然リンパ球(ILC2) / 気道炎症 / 喘息 / セルソーティング / 酵素 / 好酸球性副鼻腔炎 / グループ２型自然リンパ球(ILC2) / マウスモデル / 生存期間延長 / 抗がん作用 / NK細胞 / リンパ腫 / 肺がん / アゴニスト / MR1テトラマー / サイトカイン / ガン転移 / 肺がん細胞 / がん細胞治療 Less

自然免疫型T細胞MAIT細胞を用いた既製細胞医薬実現に向けた研究
- Principal Investigator
  
  若尾宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Dokkyo Medical University
Modulation of Food Allergy by innate immune cells
- Principal Investigator
  
  清水泰生
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Dokkyo Medical University
Importance of IL-15 responsive CD8+ cells in protective immunity against AIDS viruses
- Principal Investigator
  
  森一泰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Dokkyo Medical University
ヒトiPS細胞を用いた中皮腫治療基盤の確立
- Principal Investigator
  
  藤田博美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Dokkyo Medical University
呼吸器ウイルス感染におけるMAIT細胞の炎症コントロール機能の解析Principal Investigator
- Principal Investigator
  
  杉本智恵
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Dokkyo Medical University
自然免疫型T細胞を用いたがんの新たな細胞治療法開発
- Principal Investigator
  
  若尾宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Dokkyo Medical University
高齢化社会における免疫能維持を目指して
- Principal Investigator
  
  若尾宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Dokkyo Medical University
Towards the implementation of the cell theray for mesotherioma
- Principal Investigator
  
  FUJITA Hiroyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Dokkyo Medical University
MAIT cells in bacterial infectionPrincipal Investigator
- Principal Investigator
  
  Sugimoto Chie
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Dokkyo Medical University
Roles of innate immune cells in opportunistic infectionsPrincipal Investigator
- Principal Investigator
  
  Sugimoto Chie
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Patent

[Journal Article] Potential of MAIT cells to modulate asthma2024
- Author(s)
  Shimizu Yasuo、Sugimoto Chie、Wakao Hiroshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 73 Issue: 1 Pages: 40-47
- DOI
  10.1016/j.alit.2023.07.006
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19732, KAKENHI-PROJECT-23K25181, KAKENHI-PROJECT-23K23806
[Journal Article] Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells2024
- Author(s)
  Sugimoto Chie、Fujita Hiroyoshi、Wakao Hiroshi
- Journal Title
  
  Biomedicines
  
  Volume: 12 Issue: 1 Pages: 137-137
- DOI
  10.3390/biomedicines12010137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09654, KAKENHI-PROJECT-23K25181, KAKENHI-PROJECT-23K23806
[Journal Article] A flow-cytometry-based assay to assess the cytolytic activity against tumor cells by combination of mouse MAIT cells and natural killer cells2023
- Author(s)
  Sugimoto Chie、Fujita Hiroyoshi、Wakao Hiroshi
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 4 Pages: 102620-102620
- DOI
  10.1016/j.xpro.2023.102620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10435, KAKENHI-PROJECT-23K25181, KAKENHI-PROJECT-23K23806
[Journal Article] Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activit2022
- Author(s)
  Chie Sugimoto, Yukie Murakami, Eisuke Ishii, Hiroyoshi Fujita, Hiroshi Wakao
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.70848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10435, KAKENHI-PROJECT-21K19732
[Journal Article] Mucosal-associated invariant T cells repress group 2 innate lymphoid cells in Alternaria alternata-induced model of allergic airway inflammation2022
- Author(s)
  Shimizu Yasuo、Horigane-Konakai Yukiko、Ishii Yoshii、Sugimoto Chie、Wakao Hiroshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1005226-1005226
- DOI
  10.3389/fimmu.2022.1005226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19732, KAKENHI-PROJECT-23K23806
[Journal Article] Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy2022
- Author(s)
  Sugimoto Chie、Fujita Hiroyoshi、Wakao Hiroshi
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 12 Pages: 3160-3160
- DOI
  10.3390/biomedicines10123160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10435, KAKENHI-PROJECT-23K23806
[Journal Article] iPSC-derived mucosal-associated invariant T cells2021
- Author(s)
  Wakao Hiroshi、Sugimoto Chie
- Journal Title
  
  Recent Advances in iPSC-Derived Cell Types, Volume 4 in Advances in Stem Cell Biology
  
  Volume: 4 Pages: 31-47
- DOI
  10.1016/b978-0-12-822230-0.00012-0
- ISBN
  9780128222300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03565
[Journal Article] Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions2020
- Author(s)
  Watanabe Satoru、Fujino Masayuki、Saito Yohei、Ahmed Nursarat、Sato Hirotaka、Sugimoto Chie、Okamura Tomotaka、Hanaki Kenichi、Nakayama Emi E.、Shioda Tatsuo、Matsushima Kouji、Ansari Aftab A.、Villinger Francois、Mori Kazuyasu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 5 Pages: 1331-1344
- DOI
  10.4049/jimmunol.1901431
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08558, KAKENHI-PROJECT-20K08117, KAKENHI-PROJECT-17H03565, KAKENHI-PROJECT-18H03046
[Journal Article] High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques2018
- Author(s)
  Marcelo J Kuroda, Chie Sugimoto, Yanhui Cai, Kristen M Merino, Smriti Mehra, Mariluz Arainga, Chad J Roy, Cecily C Midkiff, Xavier Alvarez, Elizabeth S Didier, Deepak Kaushal
- Journal Title
  
  J Infect Dis
  
  Volume: 217 Issue: 12 Pages: 1865-1874
- DOI
  10.1093/infdis/jix625
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03565
[Journal Article] Mucosal-Associated Invariant T Cells in Regenerative Medicine2017
- Author(s)
  Wakao Hiroshi、Sugimoto Chie、Kimura Shinzo、Wakao Rika
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 8 Pages: 1-11
- DOI
  10.3389/fimmu.2017.01711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03565
[Journal Article] Epigenetic silencing of V(D)J recombination is a major determinant for selective differentiation of mucosal-associated invariant t cells from induced pluripotent stem cells.2017
- Author(s)
  Yutaka Saito, Chie Sugimoto, Toutai Mituyama and Hiroshi Wakao
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: e0174699-e0174699
- DOI
  10.1371/journal.pone.0174699
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430084, KAKENHI-PROJECT-15K16089
[Journal Article] The dynamics of mucosal-associated invariant T cells in multiple sclerosis2016
- Author(s)
  Chie Sugimoto, Makoto Hirotan, Kazunori Yoshikiyo, Uichi Koshimizu, Rika Wakao, Takahiro Horinouchi, Yuichi Mazaki, Tsunehiko Higashi, Toshiyuki Fukazawa, Hiroyoshi Fujita, Hidenao Sasaki and Hiroshi Wakao
- Journal Title
  
  SpringerPlus
  
  Volume: 5 Issue: 1 Pages: 1259-1259
- DOI
  10.1186/s40064-016-2923-9
- NAID
  120005906931
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430084, KAKENHI-PROJECT-26860166
[Journal Article] Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus-Infected Rhesus Macaques.2015
- Author(s)
  Yanhui Cai, Chie Sugimoto, Mariluz Arainga, Cecily C Midkiff, David Xianhong Liu, Xavier Alvarez, Andrew A Lackner, Woong-Ki Kim, Elizabeth S Didier and Marcelo J Kuroda
- Journal Title
  
  Journal of Immunology
  
  Volume: 195 Issue: 10 Pages: 4884-4891
- DOI
  10.4049/jimmunol.1501194
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430084
[Journal Article] Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis.2015
- Author(s)
  Sugimoto C, Konno T, Wakao R, Fujita H, Fujita H, Wakao H
- Journal Title
  
  PLOS ONE
  
  Volume: 10
- NAID
  120005611266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430084
[Journal Article] Differentiation Kinetics of Blood Monocytes and Dendritic Cells in Macaques: Insights to Understanding Human Myeloid Cell Development.2015
- Author(s)
  Chie Sugimoto, Atsuhiko Hasegawa, Yohei Saito, Yayoi Fukuyo, Kevin B Chiu, Yanhui Cai, Matthew W Breed, Kazuyasu Mori, Chad J Roy, Andrew A Lackner, Woong-Ki Kim, Elizabeth S Didier and Marcelo J Kuroda
- Journal Title
  
  Journal of Immunology
  
  Volume: 195 Issue: 4 Pages: 1774-1781
- DOI
  10.4049/jimmunol.1500522
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430084
[Journal Article] Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques.2015
- Author(s)
  Yanhui Cai, Chie Sugimoto, David Xianhong Liu, Cecily C Midkiff, Xavier Alvarez, Andrew A Lackner, Woong-Ki Kim, Elizabeth S Didier and Marcelo J Kuroda
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 97 Issue: 6 Pages: 1147-1153
- DOI
  10.1189/jlb.4a0914-441r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430084
[Patent] マウスMAIT様細胞ならびにMAIT細胞豊富なマウス作製とその利用2019
- Inventor(s)
  若尾宏、杉本智恵
- Industrial Property Rights Holder
  獨協医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H03565
[Presentation] Novel mouse models for studying the functions of MAIT cells2024
- Author(s)
  若尾　宏　杉本　智恵
- Organizer
  CD1d-MR1 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25181
[Presentation] Novel animal models to explore functions of MAIT cells2024
- Author(s)
  Chie Sugimoto, Hiroshi Wakao
- Organizer
  CD1 MR1 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23806
[Presentation] 新規MAIT細胞研究用マウスモデルの確立2020
- Author(s)
  杉本　智恵　若尾　宏
- Organizer
  先端モデル動物支援プラットフォーム
- Data Source
  KAKENHI-PROJECT-20K10435
[Presentation] 加齢による粘膜関連インバリアントT細胞の表現系の変化2017
- Author(s)
  杉本智恵、佐々木秀直、若尾宏
- Organizer
  第87回日本衛生学会
- Place of Presentation
  フェニックスシーガイアリゾート（宮崎県・宮崎市）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-26430084
[Presentation] MAIT細胞の機能解析のための実験モデル2017
- Author(s)
  杉本智恵、若尾宏
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17H03565
[Presentation] iPS細胞からの自然免疫型T細胞分化誘導の分子機序の統合的解析2016
- Author(s)
  若尾宏、杉本智恵、満山統泰、斎藤裕
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430084
[Presentation] iPS細胞からのヒト自然免疫型T細胞大量産生系の確立2015
- Author(s)
  杉本智恵、若尾宏
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430084
[Presentation] エイズ患者での日和見感染発症における自然免疫系細胞の重要性と新規バイオマーカーの検索2014
- Author(s)
  杉本智恵、若尾宏、藤田博美
- Organizer
  日本衛生学会
- Place of Presentation
  岡山コンベンションセンター（岡山県・岡山市）
- Year and Date
  2014-05-27
- Data Source
  KAKENHI-PROJECT-26430084
[Presentation] HIV感染者での日和見感染症発症における自然免疫系細胞の重要性2014
- Author(s)
  杉本智恵、若尾宏、藤田博美
- Organizer
  日本生化学会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-26430084

1. 若尾宏 (10280950)

# of Collaborated Projects: 9 results

# of Collaborated Products: 19 results
2. FUJITA Hiroyoshi (60142931)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. 森一泰 (20270655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 布矢純一 (40466842)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 藤野真之 (50392329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 七野成之 (70822435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 清水泰生 (80396621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KURODA Marcelo J.

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 梨井康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugimoto Chie 杉本 智恵

Research Projects

Research Products

Co-Researchers

自然免疫型T細胞MAIT細胞を用いた既製細胞医薬実現に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modulation of Food Allergy by innate immune cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Importance of IL-15 responsive CD8+ cells in protective immunity against AIDS viruses

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトiPS細胞を用いた中皮腫治療基盤の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

呼吸器ウイルス感染におけるMAIT細胞の炎症コントロール機能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然免疫型T細胞を用いたがんの新たな細胞治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高齢化社会における免疫能維持を目指して

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Towards the implementation of the cell theray for mesotherioma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MAIT cells in bacterial infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of innate immune cells in opportunistic infectionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potential of MAIT cells to modulate asthma2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A flow-cytometry-based assay to assess the cytolytic activity against tumor cells by combination of mouse MAIT cells and natural killer cells2023

Author(s)

Journal Title

DOI

Sugimoto Chie 杉本智恵